Pflugers Archiv-European Journal of Physiology

Papers
(The median citation count of Pflugers Archiv-European Journal of Physiology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)
ArticleCitations
Development of autonomic heart rate modulations during childhood and adolescence68
Immune-mediated impairment of tonic immobility defensive behavior in an experimental model of colonic inflammation60
Molecular determinants of HERG potassium channel blockade by domiphen bromide and benzethonium chloride56
Impact of aldosterone deficiency on the development of diuretic resistance in mice47
Evaluation of the relationship between intercostal muscle oxygenation measured by near-infrared spectroscopy and exercise capacity in group E COPD patients44
Combining different ion-selective channelrhodopsins to control water flux by light42
Zebrafish cardiac repolarization does not functionally depend on the expression of the hERG1b-like transcript40
Causality and scientific explanation of artificial intelligence systems in biomedicine37
Linking mitochondrial dynamics and fertility: promoting fertility by phoenixin through modulation of ovarian expression of GnRH receptor and mitochondrial dynamics proteins DRP-1 and Mfn-236
Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke36
Resting membrane state as an interplay of electrogenic transporters with various pumps31
Ryanodine receptor stabilizer S-107 rescues slow-type rat soleus muscle function after 7-day hindlimb unloading30
Piezo1, the new actor in cell volume regulation29
Decoding influences of indoor temperature and light on neural activity: entropy analysis of electroencephalographic signals28
Role of ANO1 Ca2+-activated Cl− channels in the generation of propagating spontaneous Ca2+ transients of mouse bladder suburothelial pericytes27
XPR1: a regulator of cellular phosphate homeostasis rather than a Pi exporter26
Blood transcriptomics mirror regulatory mechanisms during hibernation—a comparative analysis of the Djungarian hamster with other mammalian species26
Endogenous ion channels expressed in human embryonic kidney (HEK-293) cells26
A role for plasma membrane Ca2+ ATPases in regulation of cellular Ca2+ homeostasis by sphingosine kinase-125
Sodium retention in nephrotic syndrome is independent of the activation of the membrane-anchored serine protease prostasin (CAP1/PRSS8) and its enzymatic activity25
Is XPR1 mediating phosphate efflux?24
AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9DY atherosclerosis mouse model24
Measured GFR in murine animal models: review on methods, techniques, and procedures23
Nobel Prize for physiology or medicine in 2024 for the discovery of microRNAs: small RNAs with fundamental roles in development and disease22
Creatine monohydrate supplementation and NOX impact skeletal muscle microvascular blood flow: a pilot study22
Effects of butyrate− on ruminal Ca2+ transport: evidence for the involvement of apically expressed TRPV3 and TRPV4 channels22
Lipid metabolic reprogramming by hypoxia-inducible factor-1 in the hypoxic tumour microenvironment21
Localization of natriuretic peptide receptors A, B, and C in healthy and diseased mouse kidneys20
Identification of Dp140 and α1-syntrophin as novel molecular interactors of the neuronal CaV2.1 channel19
FGF-23 protects cell function and viability in murine pancreatic islets challenged by glucolipotoxicity19
Correction to: Nobel somatosensations and pain17
Novel functions of the anion exchanger AE4 (SLC4A9)17
Colonic expression of calcium transporter TRPV6 is regulated by dietary sodium butyrate17
Immune mediators in heart–lung communication16
What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?16
Comprehensive overview of artificial intelligence in surgery: a systematic review and perspectives16
Functional characterization of acid-sensing ion channels in the cerebellum-originating medulloblastoma cell line DAOY and in cerebellar granule neurons15
The extracellular matrix protein fibronectin promotes metanephric kidney development15
Obituary for Prof. Stephen (Ben) Walsh, Professor of Nephrology at University College London15
Acquired cystic fibrosis transmembrane conductance regulator dysfunction15
Evaluation of skeletal muscle function in male rats with doxorubicin-induced myopathy following various exercise techniques: the significant role of glucose transporter 415
Voltage-dependent CaV3.2 and CaV2.2 channels in nociceptive pathways14
Cell surface ATP synthase-released H+ and ATP play key roles in cocoa butter intake-mediated regulation of gut immunity through releases of cytokines in rat14
Regulation of endothelial function by cigarette smoke and next-generation tobacco and nicotine products14
Sphingosine kinase 1 inhibition aggravates vascular smooth muscle cell calcification14
BK channels promote action potential repolarization in skeletal muscle but contribute little to myotonia14
Neuroprotective actions of norepinephrine in neurological diseases14
Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels14
Effects of tDCS on glutamatergic pathways in epilepsy: neuroprotective and therapeutic potential14
Emerging connections between Piezo1 and BK channels in vascular smooth muscle cells13
AMPK facilitates the hypoxic ventilatory response through non-adrenergic mechanisms at the brainstem13
Basal release of 6-cyanodopamine from rat isolated vas deferens and its role on the tissue contractility13
Obituary Peter H. Deetjen (1932–2024): Editor-in-Chief of Pflügers Archiv from 1970 to 199813
Impact of combined exercise training in peripheral and diaphragm muscles and in mortality in a preclinical model of pulmonary arterial hypertension13
Harnessing retinal phagocytes to combat pathological neovascularization in ischemic retinopathies?13
The role of Na+-coupled bicarbonate transporters (NCBT) in health and disease13
Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations12
Alteration of Piezo1 signaling in type 2 diabetic mice: focus on endothelium and BKCa channel12
Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats12
Effects of aconitine on the respiratory activity of brainstem-spinal cord preparations isolated from newborn rats12
The machinery of healthy vasodilatation: an overview12
Strengthening the basics: acids and bases influence vascular structure and function, tissue perfusion, blood pressure, and human cardiovascular disease11
Commentary on “Failer et al. (2022) Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation” J Clin Invest 2022 (https://doi.org/10.1172/JCI11
Strength and muscle mass development after a resistance-training period at terrestrial and normobaric intermittent hypoxia11
The role of non-coding RNAs in neuropathic pain11
Renal water transport in health and disease11
Effects of intrarenal afferent stimulation by bradykinin on renal sympathetic nerve activity: tonic inhibition contributing to renal function11
The lateral habenula regulates stress-related respiratory responses via the monoaminergic system11
GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome11
Inconclusive evidence that breathing shapes pupil dynamics in humans: a systematic review11
Optimization of an autaptic culture system for studying cholinergic synapses in sympathetic ganglia10
CFTR—a (novel) target in ARDS10
Recent advances in acid sensing by G protein coupled receptors10
Correction to: Differential frequency-dependent reflex summation of the aortic baroreceptor afferent input10
“The great mixing machine”: multisensory integration and brain-breath coupling in the cerebral cortex10
Correction to: Effect of salivary gland removal on taste preference in mice10
Biophysical mechanisms of myocardium sodium channelopathies10
The context-dependent role of the Na+/Ca2+-exchanger (NCX) in pancreatic stellate cell migration9
Two firing modes and well-resolved Na+, K+, and Ca2+ currents at the cell-microelectrode junction of spontaneously active rat chromaffin cell on MEAs9
Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain9
Hypoxia-inducible factor-driven glycolytic adaptations in host-microbe interactions9
Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models9
Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure9
Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging‐induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats9
Determinants of hypokalemia following hypertonic sodium bicarbonate infusion9
Skeletal muscle proteins involved in fatty acid transport influence fatty acid oxidation rates observed during exercise9
Oligodendrocyte precursor cells: the multitaskers in the brain9
Interleukin 17A infusion has no acute or long-term hypertensive action in conscious unrestrained male mice9
Insights into permeability control of the fenestrated endothelium of the jejunal microvasculature9
Acute and chronic effects of physical exercise on IgA and IgG levels and susceptibility to upper respiratory tract infections: a systematic review and meta-analysis8
Correction to: Dynamic expression of homeostatic ion channels in differentiated cortical astrocytes in vitro8
The ex vivo perfused mouse adrenal gland—a new model to study aldosterone secretion8
Enhancing the quantification of post-occlusive reactive hyperemia: a multimodal optical approach8
14–3-3 protein regulation of excitation–contraction coupling8
Intracellular pH regulates the strength of the intrinsic inward rectification of Kir4.1/Kir5.1 channels8
Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice8
Phosphate intake, hyperphosphatemia, and kidney function8
Intra- and inter-session reliability of electrical detection and pain thresholds of cutaneous and muscle primary afferents in the lower back of healthy individuals8
Pregnancy induces intestinal epithelial elongation and estriol-associated activation of the Hippo signaling pathway in a mouse model8
Unlocking the potential: unveiling tyrphostins with Michael-reactive cyanoacrylate motif as promising inhibitors of human 5-lipoxygenase8
Correction to: Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers8
PKC regulates αKlotho gene expression in MDCK and NRK-52E cells8
Exposure to normobaric hypoxia shapes the acute inflammatory response in human whole blood cells in vivo8
The role of GABA in modulation of taste signaling within the taste bud8
High-fat diet-induced mitochondrial dysfunction is associated with loss of protection from ischemic preconditioning in renal ischemia reperfusion8
Uncovering the neural control of laryngeal activity and subglottic pressure in anaesthetized rats: insights from mesencephalic regions8
Dopamine receptor D4 (DRD4) negatively regulates UCP1- and ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle cells7
Extended spectrum of Cav1.3 channelopathies7
Diet-induced impairment of skeletal muscle and adipose tissue metabolic homeostasis and its prevention by probiotic administration7
Identification of a novel redox switch between metabolism and cardiac function using HyPer power7
Galectin-3 protects distal convoluted tubules in rhabdomyolysis-induced kidney injury7
hPSC gene editing for cardiac disease therapy7
The crucial decade that ion channels were proven to exist7
Comment on “spatially dependent tissue distribution of thyroid hormones by plasma thyroid hormone binding proteins”7
Cargo-specific effects of hypoxia on clathrin-mediated trafficking7
Correction to: Two adjacent phosphorylation sites in the C-terminus of the channel’s α-subunit have opposing effects on epithelial sodium channel (ENaC) activity7
Microbiota, mitochondria, and epigenetics in health and disease: converging pathways to solve the puzzle7
Does the composition of urinary extracellular vesicles reflect the abundance of renal Na+/phosphate transporters?7
Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link?7
Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and KCa3.1 ion channels, but involves phosphoinositide 3-kinase7
Proteolytic ENaC activation in health and disease—a complicated puzzle7
Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes7
Recent advances and current limitations of available technology to optically manipulate and observe cardiac electrophysiology7
Lessons from a model: early glucagon dysfunction in type 2 diabetes7
Cobalt chloride postconditioning as myoprotective therapy in cardiac ischemia–reperfusion7
Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications6
Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A2 ex vivo does not involve a direct action on the contractile apparatus6
Is there a molecular basis for solvent drag in the renal proximal tubule?6
Angiotensin receptors and α1B-adrenergic receptors regulate native IK(ACh) and phosphorylation-deficient GIRK4 (S418A) channels through different PKC isoforms6
MiR-10b-3p alleviates cerebral ischemia/reperfusion injury by targeting Krüppel-like factor 5 (KLF5)6
Role of glucocorticoid receptor mutations in hypertension and adrenal gland hyperplasia6
Correction to: Liraglutide versus pramlintide in protecting against cognitive function impairment through affecting PI3K/AKT/GSK‑3β/TTBK1 pathway and decreasing Tau hyperphosphorylation in high‑fat di6
Effects of aurantiamide on a rat model of renovascular arterial hypertension6
E-cigarette effects on vascular function in animals and humans6
Tissue chaperoning—the expanded functions of fetuin-A beyond inhibition of systemic calcification6
Intracellular cAMP signaling-induced Ca2+ influx mediated by calcium homeostasis modulator 1 (CALHM1) in human odontoblasts6
Role of the endothelial reverse mode sodium-calcium exchanger in the dilation of the rat middle cerebral artery during hypoosmotic hyponatremia6
25-Hydroxycholesterol modulates synaptic vesicle endocytosis at the mouse neuromuscular junction6
Take a big sip and shrink it with ASOR6
Inhibition of Rho-kinase by fasudil contributes to the modulation of the synaptic plasticity response in the rat hippocampus6
Excitation-secretion coupling in chromaffin cells of the adrenal gland: Where does calcium come from?6
No single place for space: neuronal representation of location beyond the hippocampus6
New insights about non-neurogenic excitability revealed by MEA recordings from rat adrenal chromaffin cells6
Personalising dietary advice for disease prevention: concepts and experiences5
Murine Alox8 versus the human ALOX15B ortholog: differences and similarities5
Melatonin and mesenchymal stem cells co-administration alleviates chronic obstructive pulmonary disease via modulation of angiogenesis at the vascular-alveolar unit5
Human platelet mitochondria improve the mitochondrial and cardiac function of donor heart5
Challenges and applications in generative AI for clinical tabular data in physiology5
PTHrP attenuates spontaneous contractions in detrusor smooth muscle of the rat bladder by activating spontaneous transient outward potassium currents5
Sodium retention in the nephrotic syndrome and the non-enzymatic function of prostasin5
Carotid body physiology meets cytochrome c oxidase crystallography Commentary to Ortega-Sáenz P, López-Barneo J. Physiology of the Carotid Body: From Molecules to Disease. Annu Rev Physiol 82: 127–1495
Pendrin: linking acid base to blood pressure5
Lateral hypothalamic area high-frequency deep brain stimulation rescues memory decline in aged rat: behavioral, molecular, and electrophysiological study5
Absence of claudin-3 does not alter intestinal absorption of phosphate in mice5
Pendrin abundance, subcellular distribution, and function are unaffected by either αENaC gene ablation or by increasing ENaC channel activity5
Expression of phosphate and calcium transporters and their regulators in parotid glands of mice5
( −)-Epicatechin and cardiometabolic risk factors: a focus on potential mechanisms of action5
Long-term continuous monitoring of arrhythmias in pigs with insertable cardiac monitors5
Circadian adaptations to regular treadmill exercise alter temporal changes in dopamine and serotonin activity in brain areas5
Europhysiology 2022: bringing together the physiologists of Europe and the World5
Relaxin does not prevent development of hypoxia-induced pulmonary edema in rats5
Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transporters5
Remembering Rudolf Höber, the charming professor: address to the 100th Conference of the German Physiological Society, Frankfurt, 30 September 20215
Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells5
Artificial light at night suppresses the day-night cardiovascular variability: evidence from humans and rats5
Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES5
Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation5
Importance and implications of exosomes in nephrology and urology4
Like a Phoenix Reborn from the Ashes: TASK-5 - Commentary to Rinne & Schick et al.4
Vasoconstriction during non-hypotensive hypovolemia is not associated with activation of baroreflex: A causality-based approach4
The omega of TRPM7 channels in trigeminal neuralgia4
Maternal nutrition and effects on offspring vascular function4
Flexible and multifaceted: the plasticity of renin-expressing cells4
Novel algorithms for improved detection and analysis of fluorescent signal fluctuations4
The obesity pandemic and its impact on non-communicable disease burden4
Body and mind: how somatic feedback signals shape brain activity and cognition4
Potassium homeostasis: sensors, mediators, and targets4
Secretin: a hormone for HCO3− homeostasis4
Effect of a resistance exercise at acute moderate altitude on muscle health biomarkers4
Increased weight-bearing load reduces biological body weight while sodium and water balances are unaffected4
Effects of reversible SERCA inhibition on catecholamine exocytosis and intracellular [Ca2+] signaling in chromaffin cells from normotensive Wistar Kyoto rats and spontaneously hypertensive rats4
Do mechanosensitive Piezo channels set in motion cell volume regulation?4
Fatiguing high-intensity intermittent exercise depresses maximal Na+-K+-ATPase activity in human skeletal muscle assessed using a novel NADH-coupled assay4
Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel4
Normobaric hypoxia shows enhanced FOXO1 signaling in obese mouse gastrocnemius muscle linked to metabolism and muscle structure and neuromuscular innervation4
Neuronal subtype-dependent kinetics of EPSCs induced by thalamocortical projections from the ventroposteromedial thalamic nucleus to the insular cortex in rats4
How ceramides affect the development of colon cancer: from normal colon to carcinoma4
Reinhardt Rüdel 4
The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives4
The role of acid-sensing ion channels in monosodium urate-induced gouty pain in mice4
Evaluation of the use of the myocardial performance index as a parameter of cardiac function in two experimental models of heart disease: myocardial infarction and pulmonary hypertension4
Combined exercise-induced modulation of Notch pathway and muscle quality in senescence-accelerated mice4
Electrophysiological characterization of ectopic spontaneous discharge in axotomized and intact fibers upon nerve transection: a role in spontaneous pain?4
The kidneys matter4
How kidney function adapts to changes in acid–base balance: the AE4 transporter as a central acid–base sensor in tubular cells4
Impact of stretch on sarcomere length variability in isolated fully relaxed rat cardiac myocytes4
Correction to: pH‑regulated single cell migration4
The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back4
Thermosensitivity of TREK K2P channels is controlled by a PKA switch and depends on the microtubular network4
Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats4
Atypical sphingosine-1-phosphate metabolites—biological implications of alkyl chain length4
Liraglutide versus pramlintide in protecting against cognitive function impairment through affecting PI3K/AKT/GSK-3β/TTBK1 pathway and decreasing Tau hyperphosphorylation in high-fat diet- streptozoci4
The impact of progredient vessel and tissue stiffening for the development of metabolic syndrome4
Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training4
The relevance of RNA–DNA interactions as regulators of physiological functions4
Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity3
Acupoint catgut embedding attenuates oxidative stress and cognitive impairment in chronic cerebral ischemia by inhibiting the Ang II/AT1R/NOX axis3
Tobacco smoking and vascular biology and function: evidence from human studies3
Metabolic mechanisms of acute proximal tubular injury3
Muscle metaboreflex activation during hypercapnia modifies nonlinear heart rhythm dynamics, increasing the complexity of the sinus node autonomic regulation in humans3
Hypotension in hereditary cardiomyopathy3
Physiological regulation of oral saliva ion composition and flow rate are not coupled in healthy humans—Partial revision of our current knowledge required3
In silico optical modulation of spiral wave trajectories in cardiac tissue3
Acute activation of human epithelial sodium channel (ENaC) by serum and glucocorticoid inducible kinase 1 (SGK1) requires prior cleavage of the channel’s γ-subunit at its proximal cleavage site3
Elabela alleviates ischemia/reperfusion-induced hepatic and remote organ injury by inhibiting oxidative stress in rats3
Effects of physical training on hypothalamic neuronal activation and expressions of vasopressin and oxytocin in SHR after running until fatigue3
Enzymatic vitamin A2 production enables red-shifted optogenetics3
Electrophysiological characterization of a CaV3.1 calcium channel mutation linked to trigeminal neuralgia3
Heat production during exercise in pregnancy: discerning the contribution of total body weight3
Exercise-induced cardiac mitochondrial reorganization and enhancement in spontaneously hypertensive rats3
Revisiting reactive oxygen species production in hypoxia3
Direct investigation of cell contraction signal networks by light-based perturbation methods3
Stress-induced impairment of parasympathetic NO-mediated inhibition of sympathetic vasoconstriction in submucosal arteriole of rat rectum3
Spatio-temporal segregation between sensory relay and swallowing pre-motor population activities by optical imaging in the rat nucleus of the solitary tract3
Intravascular volume expansion is prominently overestimated via hemoglobin concentration: a placebo-controlled and cross-over trial3
Ethanol-induced dysfunction of the mesenteric perivascular adipose tissue is driven by mineralocorticoid receptors3
Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth3
PHD1-3 oxygen sensors in vivo—lessons learned from gene deletions3
Oxygen dissociation curve inflection point during incremental exercise: a trigger for the Bohr effect3
SGLT2 inhibitor as a potential therapeutic approach in hyperthyroidism-induced cardiopulmonary injury in rats3
Something old, something new, something borrowed, something blue and a silver sixpence in her shoe3
A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects3
Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation3
The effect of chronic intermittent hypobaric hypoxia improving liver damage in metabolic syndrome rats through ferritinophagy3
Contribution of TRPC3-mediated Ca2+ entry to taste transduction3
Explainable artificial intelligence for spectroscopy data: a review3
Mild hyperbaric oxygen exposure protects heart during ischemia/reperfusion and affects vascular relaxation3
Loss of the large conductance calcium-activated potassium channel causes an increase in mitochondrial reactive oxygen species in glioblastoma cells3
L-cysteine modulates visceral nociception mediated by the CaV2.3 R-type calcium channels3
Oxalate secretion is stimulated by a cAMP-dependent pathway in the mouse cecum3
Protein carbonylation causes sarcoplasmic reticulum Ca2+ overload by increasing intracellular Na+ level in ventricular myocytes3
IRBITs, signaling molecules of great functional diversity3
Correction to: Intertwined regulators: hypoxia pathway proteins, microRNAs, and phosphodiesterases in the control of steroidogenesis2
New insights into the mechanisms of anandamide-induced airway dilation placing its degradation enzyme, FAAH center stage. Commentary on: Simon A, von Einem T, Seidinger A, Matthey M, Bindila L, Wenzel2
Optogenetic interrogation of cell signalling: human neuropsin (hOPN5) represents a potent tool for controlling the Gq pathway with light2
Effect of hypoxia on GLP-1 secretion – an in vitro study using enteroendocrine STC-1 -cells as a model2
Lectin-mediated, time-efficient, and high-yield sorting of different morphologically intact nephron segments2
The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E2, while Cftr regulates de novo mucus release in response to carbamylcholine2
Hyperosmolality activates polycystin-2 and TRPM4 in renal primary cilium2
Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes2
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