European Journal of Clinical Pharmacology

Article	Citations
Therapeutic drug monitoring of oral targeted antineoplastic drugs	114
Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies	78
What about COVID-19 and arachidonic acid pathway?	59
The added value of pirfenidone to fight inflammation and fibrotic state induced by SARS-CoV-2	58
Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review	47
Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review	45
Global prevalence and types of complementary and alternative medicines use amongst adults with diabetes: systematic review and meta-analysis	44
Safety, pharmacodynamic, and pharmacokinetic characterization of vericiguat: results from six phase I studies in healthy subjects	42
Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials	34
Pattern of treatment of behavioural and psychological symptoms of dementia and pain: evidence on pharmacoutilization from a large real-world sample and from a centre for cognitive disturbances and dem	33
A phase I study assessing the safety, tolerability, immunogenicity, and low-density lipoprotein cholesterol-lowering activity of immunotherapeutics targeting PCSK9	32
Ivy leaf (Hedera helix) for acute upper respiratory tract infections: an updated systematic review	29
Comparative effectiveness of dopamine agonists and monoamine oxidase type-B inhibitors for Parkinson’s disease: a multiple treatment comparison meta-analysis	28
Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials	28
Predisposing factors for the development of diabetic ketoacidosis with lower than anticipated glucose levels in type 2 diabetes patients on SGLT2-inhibitors: a review	26
Pharmacokinetics and pharmacodynamics of intranasal remimazolam—a randomized controlled clinical trial	26
Safety and efficacy of tolcapone in Parkinson’s disease: systematic review	25
Can iron chelation as an adjunct treatment of COVID-19 improve the clinical outcome?	25
Pharmacotherapy of Alzheimer’s disease: an overview of systematic reviews	24
Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19	24
Tocilizumab for treating COVID-19: a systemic review and meta-analysis of retrospective studies	22
Serotonin syndrome by drug interactions with linezolid: clues from pharmacovigilance-pharmacokinetic/pharmacodynamic analysis	22
The effect of tocilizumab on mortality in hospitalized patients with COVID-19: a meta-analysis of randomized controlled trials	21
A real or apparent decrease in glomerular filtration rate in patients using olaparib?	21
Bleeding and thromboembolism due to drug-drug interactions with non-vitamin K antagonist oral anticoagulants—a Swedish, register-based cohort study in atrial fibrillation outpatients	20

Selective serotonin reuptake inhibitors in the treatment of depression, anxiety, and post-traumatic stress disorder in substance use disorders: a Bayesian meta-analysis	19
Off-label use of dexmedetomidine in paediatric anaesthesiology: an international survey of 791 (paediatric) anaesthesiologists	18
Improving medication adherence and effective prescribing through a patient-centered prescription model in patients with multimorbidity	18
Visual snow syndrome after start of citalopram—novel insights into underlying pathophysiology	17
Prevalence, contributory factors and severity of medication errors associated with direct-acting oral anticoagulants in adult patients: a systematic review and meta-analysis	17
Second-generation antipsychotic use during pregnancy and risk of congenital malformations	17
Trends in the use of oral anticoagulants, antiplatelets and statins in four European countries: a population-based study	16
Proton pump inhibitor use: systematic review of global trends and practices	16
Iron chelation may harm patients with COVID-19	16
Medication-related adverse events in health care—what have we learned? A narrative overview of the current knowledge	16
Sertraline concentrations in pregnant women are steady and the drug transfer to their infants is low	15
Hepatotoxicity in patients with solid tumors treated with PD-1/PD-L1 inhibitors alone, PD-1/PD-L1 inhibitors plus chemotherapy, or chemotherapy alone: systematic review and meta-analysis	15
Potentially inappropriate medication in older psychiatric patients	15
Safety profile of COVID-19 drugs in a real clinical setting	15
Effect of SAcubitril/Valsartan on left vEntricular ejection fraction and on the potential indication for Implantable Cardioverter Defibrillator in primary prevention: the SAVE-ICD study	15
REview of potentially inappropriate MEDIcation pr[e]scribing in Seniors (REMEDI[e]S): French implicit and explicit criteria	15
Pharmacokinetic variability of phenobarbital: a systematic review of population pharmacokinetic analysis	15
Pharmacoepidemiological methods for computing the duration of pharmacological prescriptions using secondary data sources	15
Population pharmacokinetics of lopinavir/ritonavir in Covid-19 patients	14
Safety of azithromycin in pediatrics: a systematic review and meta-analysis	14
Use of tramadol and other analgesics following media attention and risk minimization actions from regulators: a Danish nationwide drug utilization study	13
Optimization of infliximab therapy in inflammatory bowel disease using a dashboard approach—an Indian experience	13
Association between newly initiated thiazide diuretics and hospitalization due to hyponatremia	13
Hospitalizations and deaths related to adverse drug events worldwide: Systematic review of studies with national coverage	13
The association between acid-suppressive agent use and the risk of cancer: a systematic review and meta-analysis	13
Interventions to optimize prescribed medicines and reduce their misuse in chronic non-malignant pain: a systematic review	13
The safety of systemic Janus kinase inhibitors in atopic dermatitis: a systematic review and network meta-analysis	13
External evaluation of population pharmacokinetic models for continuous administration of meropenem in critically ill adult patients	13
Acid suppressant use in association with incidence and severe outcomes of COVID-19: a systematic review and meta-analysis	12
A comparison between the assessments of progression-free survival by local investigators versus blinded independent central reviews in phase III oncology trials	12
Switching from a traditional undergraduate programme in (clinical) pharmacology and therapeutics to a problem-based learning programme	12
Effects of ABCG2 and SLCO1B1 gene variants on inflammation markers in patients with hypercholesterolemia and diabetes mellitus treated with rosuvastatin	12
JAK inhibitors and risk of major cardiovascular events or venous thromboembolism: a self-controlled case series study	12
Adjuvant use of melatonin for relieving symptoms of painful diabetic neuropathy: results of a randomized, double-blinded, controlled trial	12
Plasma levels of direct oral anticoagulants in atrial fibrillation patients at the time of embolic stroke: a pilot prospective multicenter study	12
Use of ketamine and esketamine for depression: an overview of systematic reviews with meta-analyses	12
Aspirin in people with dementia, long-term benefits, and harms: a systematic review	12
The 10-year trend in drug prescriptions for attention-deficit/hyperactivity disorder (ADHD) in Germany	12
Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis	12
Influences of ABC transporter and CYP3A4/5 genetic polymorphisms on the pharmacokinetics of lenvatinib in Chinese healthy subjects	12
Loncastuximab tesirine: an effective therapy for relapsed or refractory diffuse large B-cell lymphoma	12
Who gets prescriptions for proton pump inhibitors and why? A drug-utilization study with claims data in Bavaria, Germany, 2010–2018	12
Alliance between selective serotonin reuptake inhibitors and fracture risk: an updated systematic review and meta-analysis	12
A drug–drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers	12
Use of ketamine in patients with refractory severe asthma exacerbations: systematic review of prospective studies	12
External evaluation of published population pharmacokinetic models of polymyxin B	12
Clinical implications of assessment of apixaban levels in elderly atrial fibrillation patients: J-ELD AF registry sub-cohort analysis	12
Safety of hydroxychloroquine in COVID-19 and other diseases: a systematic review and meta-analysis of 53 randomized trials	12
Intravenous lidocaine vs. NSAIDs for migraine attack in the ED: a prospective, randomized, double-blind study	11
An open-label, positron emission tomography study of the striatal D2/D3 receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants	11

Benzodiazepine withdrawal in older people: what is the prevalence, what are the signs, and which patients?	11
Cinemeducation in clinical pharmacology: using cinema to help students learn about pharmacovigilance and adverse drug reactions	11
Estimation of a preliminary therapeutic reference range for children and adolescents with tic disorders treated with tiapride	11
Incremental net benefit of lipid-lowering therapy with PCSK9 inhibitors: a systematic review and meta-analysis of cost-utility studies	11
Why hospital-based healthcare professionals do not report adverse drug reactions: a mixed methods study using the Theoretical Domains Framework	11
Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review	11
The clinical and educational outcomes of an inter-professional student-led medication review team, a pilot study	11
Quality of adverse event reporting in clinical trials of remdesivir in patients with COVID-19	11
Influence of CYP2C9 and CYP2A6 on plasma concentrations of valproic acid: a meta-analysis	11
Trends and patterns in EU(7)-PIM prescribing to elderly patients in Germany	10
Association between glucagon-like peptide-1 receptor gene polymorphism and treatment response to GLP1R agonists in Chinese patients with type 2 diabetes: a prospective cohort study	10
Estimation of the area under concentration-time curve of polymyxin B based on limited sampling concentrations in Chinese patients with severe pneumonia	10
Drug utilisation in neonatal units in England and Wales: a national cohort study	10
Evaluation of drug-drug interactions of pemigatinib in healthy participants	10
Pharmaceuticals and Environment: a web-based decision support for considering environmental aspects of medicines in use	10
Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection: prospects for use	10
Low- vs high-dose ARNI effects on clinical status, exercise performance and cardiac function in real-life HFrEF patients	10
What should patients do if they miss a dose? A systematic review of patient information leaflets and summaries of product characteristics	10
Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department	10
Prevalence and clinical predictors of inappropriate direct oral anticoagulant dosage in octagenarians with atrial fibrillation	10
Reply: Iron chelation may harm patients with COVID-19	10
Effect of a proton-pump inhibitor on intestinal microbiota in patients taking low-dose aspirin	10
Direct oral anticoagulant safety during breastfeeding: a narrative review	10
Influence of N-acetyltransferase 2 (NAT2) genotype/single nucleotide polymorphisms on clearance of isoniazid in tuberculosis patients: a systematic review of population pharmacokinetic models	9
Body weight, CYP2C19, and P2Y12 receptor polymorphisms relate to clopidogrel resistance in a cohort of Chinese ischemic stroke patients with aspirin intolerance	9
Articles provided insufficient information to conduct an appropriate retrospective assessment of the pragmatic/explanatory features of medicine trials with the PRECIS-2 tool	9
Uptake of biosimilar trastuzumab in Denmark compared with other European countries: a comparative study and discussion of factors influencing implementation and uptake of biosimilars	9
Prediction of the exposure to a 400-mg daily dose of efavirenz in pregnancy: is this dose adequate in extensive metabolisers of CYP2B6?	9
Potentially inappropriate prescribing in older hospitalized Dutch patients according to the STOPP/START criteria v2: a longitudinal study	9
Serum concentrations of antidepressants, antipsychotics, and antiepileptics over the bariatric surgery procedure	9
Hypertension and Covid-19 vaccines: are there any differences between the different vaccines? A safety signal	9
Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range	9
Efficacy and safety profile of statins in patients with cancer: a systematic review of randomised controlled trials	9
Effectiveness of palonosetron versus granisetron in preventing chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis	9
Daridorexant for the treatment of insomnia disorder: findings and implications	9
Non-steroidal anti-inflammatory drug-associated acute kidney injury: does short-term NSAID use pose a risk in hospitalized patients?	9
Doctor’s aptitude for switching from innovator etanercept to biosimilar etanercept in inflammatory rheumatic diseases: experience from a single French rheumatology tertiary care center	8
The comparative impact among different intensive statins and combination therapies with niacin/ezetimibe on carotid intima-media thickness: a systematic review, traditional meta-analysis, and network	8
DRESS characteristics according to the causative medication	8
Evaluation of iberdomide and cytochrome p450 drug-drug interaction potential in vitro and in a phase 1 study in healthy subjects	8
A case series of the rifampin-warfarin drug interaction: focus on practical warfarin management	8
The effects of trazodone on human cognition: a systematic review	8
Drug repositioning in the COVID-19 pandemic: fundamentals, synthetic routes, and overview of clinical studies	8
Patients’ experiences on adverse drug reactions reporting: a qualitative study	8
Safety profile of chimeric antigen receptor T-cell immunotherapies (CAR-T) in clinical practice	8
Maternal non-steroidal anti-inflammatory drug exposure during pregnancy and risk of miscarriage: a systematic review and meta-analysis	8
Serious adverse drug reactions with hydroxychloroquine: a pharmacovigilance study in Vigibase®	8
Comparing the clinical outcomes across different sodium/glucose cotransporter 2 (SGLT2) inhibitors in heart failure patients: a systematic review and network meta-analysis of randomized controlled tri	8
Quantity is not enough: completeness of suspected adverse drug reaction reports in Spain—differences between regional pharmacovigilance centres and pharmaceutical industry	8
Incidence risk of PD-1/PD-L1–related pneumonia and diarrhea in non-small cell lung cancer (NSCLC) patients: a systematic review and meta-analysis of randomized controlled trials	8
Model-based simulation to support the extended dosing regimens of atezolizumab	8
Influence of formulation and route of administration on ketamine’s safety and tolerability: systematic review	8
Adjuvant use of melatonin for pain management in dysmenorrhea — a randomized double-blinded, placebo-controlled trial	8
Impact of changes in controlled drugs legislation on benzodiazepine receptor agonist prescribing in Ireland: a repeated cross-sectional study	8
COVID-19 and antiepileptic drugs: an approach to guide practices when nirmatrelvir/ritonavir is co-prescribed	8
Flucloxacillin decreases tacrolimus blood trough levels: a single-center retrospective cohort study	8
Pharmacogenetics of tamoxifen therapy in Asian populations: from genetic polymorphism to clinical outcomes	8
Different interventions for preventing postoperative catheter-related bladder discomfort: a systematic review and meta-analysis	8
Dasiglucagon: an effective medicine for severe hypoglycemia	8
Adverse drug reaction management in hospital settings: review on practice variations, quality indicators and education focus	8
Use of the French healthcare insurance database to estimate the prevalence of exposure to potential drug-drug interactions	8
Re-recognizing bromhexine hydrochloride: pharmaceutical properties and its possible role in treating pediatric COVID-19	8
Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: A systematic review and meta-analysis	8
Correlation between single-nucleotide polymorphisms and statin-induced myopathy: a mixed-effects model meta-analysis	8
Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model	8
Evaluation of pharmacological interventions in the management of adenomyosis: a systematic review	7
Arrhythmias related to antipsychotics and antidepressants: an analysis of the summaries of product characteristics of original products approved in Germany	7
Loss of function polymorphisms in SLCO1B1 (c.521T>C, rs4149056) and ABCG2 (c.421C>A, rs2231142) genes are associated with adverse events of rosuvastatin: a case–control study	7
Benefits and adverse effects of ACE inhibitors in patients with heart failure with reduced ejection fraction: a systematic review and meta-analysis	7
Potentially inappropriate medication use and the hospitalization rate among Thai elderly patients: a retrospective cohort study	7
Impact of computerised physician order entry (CPOE) on the incidence of chemotherapy-related medication errors: a systematic review	7
Case series of chronic spontaneous urticaria following COVID-19 vaccines: an unusual skin manifestation	7
Role of serotonin and norepinephrine transporters in antidepressant-induced arterial hypertension: a pharmacoepidemiological-pharmacodynamic study	7
Strategies to prevent drug incompatibility during simultaneous multi-drug infusion in intensive care units: a literature review	7
Effect of GLP-1R rs2254336 and rs3765467 polymorphisms on gastrointestinal adverse reactions in type 2 diabetes patients treated with liraglutide	7
Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen	7
Diltiazem on tacrolimus exposure and dose sparing in Chinese pediatric primary nephrotic syndrome: impact of CYP3A4, CYP3A5, ABCB1, and SLCO1B3 polymorphisms	7
Potentially inappropriate medication in acute hospitalized elderly patients with polypharmacy: an observational study comparing PRISCUS, STOPP, and Beers criteria	7
Response and Adherence to Nilotinib in Daily practice (RAND study): an in-depth observational study of chronic myeloid leukemia patients treated with nilotinib	7
The European Prescribing Exam: assessing whether European medical students can prescribe rationally and safely	7

Correct use of non-indexed eGFR for drug dosing and renal drug-related problems at hospital admission	7
Adverse drug reactions to anti-diabetic drugs are commonest in patients whose treatment do not adhere to diabetes management clinical guidelines: cross-sectional study in a tertiary care service in su	7
Feasibility study and evaluation of expert opinion on the semi-automated meta-analysis and the conventional meta-analysis	7
Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data	7
Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose	7
Efficacy of high-dose atorvastatin or rosuvastatin loading in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a meta-analysis of randomized controlled trials with	7
Paracetamol overdose in the newborn and infant: a life-threatening event	7
Impact of concomitant acid suppressive therapy on pazopanib efficacy and dose reductions in patients with metastatic renal cell carcinoma	7
Efficacy and safety of corticosteroid therapy in patients with cardiac arrest: a systematic review of randomised controlled trials	7
Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus	7
Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and Δ9-tetrahydrocannabinol: a pilot study	7
A patient-centred web-based adverse drug reaction reporting system identifies not yet labelled potential safety issues	6
Implementation and management outcomes of pharmacogenetic CYP2C19 testing for clopidogrel therapy in clinical practice	6
Coadministration of tizanidine and ciprofloxacin: a retrospective analysis of the WHO pharmacovigilance database	6
Safety and CSF distribution of high-dose erlotinib and gefitinib in patients of non–small cell lung cancer (NSCLC) with brain metastases	6
Effectiveness and safety of vonoprazan-based regimens compared with those of proton pump inhibitor (PPI)–based regimens as first-line agents for Helicobacter pylori: a meta-analysis of randomized clin	6
First-in-human dose: current status review for better future perspectives	6
The influence of recipient SLCO1B1 rs2291075 polymorphism on tacrolimus dose–corrected trough concentration in the early period after liver transplantation	6
Tacrolimus monitoring parameters are not associated with acute cellular rejection following lung transplantation	6
Effects of ABCB1 and ABCG2 polymorphisms on the pharmacokinetics of abemaciclib	6
Physiologically based pharmacokinetic combined BTK occupancy modeling for optimal dosing regimen prediction of acalabrutinib in patients alone, with different CYP3A4 variants, co-administered with CYP	6
CYP450 polymorphisms and clinical pharmacogenetics of ibuprofen after lower third molar extraction	6
Serum 4β-hydroxycholesterol increases during fluconazole treatment	6
EurOP2E – the European Open Platform for Prescribing Education, a consensus study among clinical pharmacology and therapeutics teachers	6
Feasibility and usability of a mobile health tool on anticoagulation management for patients with atrial fibrillation: a pilot study	6
The association of GATM polymorphism with statin-induced myopathy: a systematic review and meta-analysis	6
Drug-related deaths among inpatients: a meta-analysis	6
Waivers of informed consent in research with competent participants and the Declaration of Helsinki	6
Drug exposure for PDA closure in France: a prospective, cohort-based, analysis	6
Population pharmacokinetics and dose optimization of ceftriaxone for children with community-acquired pneumonia	6
The PRECIS-2 tool seems not to be useful to discriminate the degree of pragmatism of medicine masked trials from that of open-label trials	6
Association of FMO3 rs1736557 polymorphism with clopidogrel response in Chinese patients with coronary artery disease	6
Comparison of statins for primary prevention of cardiovascular disease and persistent physical disability in older adults	6
Linezolid-associated serotonin toxicity: a systematic review	6
Effects of pirenzepine on vonoprazan-induced gastric acid inhibition and hypergastrinemia	6
Successful deprescribing of proton pump inhibitors with a patient-centered process: the DESPIBP Project	6
Remdesivir-induced symmetrical drug–related intertriginous and flexural exanthema (SDRIFE)? A case report with review of the literature	6
Borrowing external information to improve Bayesian confidence propagation neural network	6
Remdesivir treatment and clinical outcome in non-severe hospitalized COVID-19 patients: a propensity score matching multicenter Italian hospital experience	6
External evaluation of population pharmacokinetic models for voriconazole in Chinese adult patients with hematological malignancy	6
CYP3A5 and PPARA genetic variants are associated with low trough concentration to dose ratio of tacrolimus in kidney transplant recipients	6
Paradoxical adverse drug reactions: descriptive analysis of French reports	6
Adverse drug reactions in infants, children and adolescents exposed to antidepressants: a French pharmacovigilance study	6
Impacts of cachexia progression in addition to serum IgG and blood lymphocytes on serum nivolumab in advanced cancer patients	6
Evaluating the safety and efficacy of daprodustat for anemia of chronic kidney disease: a meta-analysis of randomized clinical trials	6
The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients—a randomized, controlled trial	6
Investigation of pharmacokinetic and clinical outcomes of various meropenem regimens in patients with ventilator-associated pneumonia and augmented renal clearance	6
Single dose epidural hydromorphone in labour pain: maternal pharmacokinetics and neonatal exposure	6
Direct oral anticoagulants versus warfarin in nonvalvular atrial fibrillation patients with prior gastrointestinal bleeding: a network meta-analysis of real-world data	6