OOIR: Observatory of International Research

Papers

(The median citation count of Pharmacological Reviews is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	686
Table of Contents	460
Neurobiological Mechanisms of Nicotine Reward and Aversion	285
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	246
Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review	159
L-Type Calcium Channel Blockers: A Potential Novel Therapeutic Approach to Drug Dependence	118
Editorial Board	109
Review of Natural Language Processing in Pharmacology	104
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	103
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	96
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	96
The Nitrogen Mustards	96
Table of Contents	93
Table of Contents	90
The endocannabinoidomes: pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	89
Table of Contents	87
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	85
Pharmaceutical Perspectives on Oligonucleotide Therapeutics and Delivery Systems	78
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	77
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	76
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	74
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	66
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	65
Table of Contents	65
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	64

Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	63
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	62
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	59
Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease	59
The Hippo pathway: Organ size control and beyond	57
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	57
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	56
Neurobiology of the incubation of drug craving: An update	52
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	50
Dopamine, Immunity, and Disease	49
Nonhormonal Male Contraceptive Development—Strategies for Progress	48
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	48
Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?	46
Editorial Board	42
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	42
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	41
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	41
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	40
Analgesic Potential of Terpenes Derived from Cannabis sativa	40
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	39
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	38
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	38
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	37
Animal Behavior in Psychedelic Research	35
Vitamin D and its analogs in immune system regulation	34
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	33
The Development of Cannabinoids as Therapeutic Agents in the United States	32
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines	32
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	31
Table of Contents	30
Editorial Board	30
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	26
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	26
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	24
Table of Contents	23
Drugging dancing protein clouds: A close look at disorder-based drug design	23
Table of Contents	22
α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials	21
Anticoagulants: From chance discovery to structure-based design	21
Adrenoceptor Desensitization: Current Understanding of Mechanisms	20
Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases	19
From bone sentinel to immune savant: Vitamin D and its receptor’s pharmacology	19
Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance	19
Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis	18
Pharmacological Approaches to Hearing Loss	17
Drug-Drug Interactions and Synergy: From Pharmacological Models to Clinical Application	17
Precision Medicine in Rheumatic Diseases: Unlocking the Potential of Antibody-Drug Conjugates	17
Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor	16
Analyzing lognormal data: A nonmathematical practical guide	16
International Union of Basic and Clinical Pharmacology CXV: The Class F of G Protein-Coupled Receptors	16

Summing Up Pharmacological Reviews’ 75th Anniversary Year and a Look to the Future	15
Leveraging Lymphatic System Targeting in Systemic Lupus Erythematosus for Improved Clinical Outcomes	15
Changing Cerebral Blood Flow, Glucose Metabolism, and Dopamine Binding Through Transcranial Magnetic Stimulation: A Systematic Review of Transcranial Magnetic Stimulation-Positron Emission Tomography	14
Pharmacology and Precision Medicine—Preparing for the Next Era in Clinical Medicine—Editorial	14
Pharmacological therapies for male infertility	14
Table of Contents	14
Editorial Board	14
Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust	13
Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction	13
Inhaled Medicines: Past, Present, and Future	13
A Chance to Grow and Excel as an Associate Editor of Pharmacological Reviews—Editorial	12
Pharmacologic treatments for gastroparesis	12
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels	12
Editorial Board	12
Senotherapy for Chronic Lung Disease	12
A 25-Year Journey as Author and Associate Editor of Pharmacological Reviews—Editorial	12
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4	11
Multi- and polypharmacology of carbonic anhydrase inhibitors	11
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies	11
Topically Applied Therapies for the Treatment of Skin Disease: Past, Present, and Future	11
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies	10
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials	10
International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors—Structures, functions, activators, and blockers	9
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies	9
Ferroptosis and pathogenesis of neuritic plaques in Alzheimer disease	9
Cyclic nucleotide phosphodiesterases as drug targets	9
Bioactives from marine resources as natural health products: A review	9
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors	9
Cytochrome P450 Enzymes: The Old Pandora’s Box with an Ever-Growing Hope for Therapy Optimization and Drug Development—Editorial	8
Reversing the odds: Advanced and emerging therapeutic strategies for male infertility	8
Table of Contents	8
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain	8
Announcement	7
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling	7
Nitric Oxide Signaling and Regulation in the Cardiovascular System: Recent Advances	7
Pharmacological treatment for metabolic dysfunction–associated steatotic liver disease and related disorders: Current and emerging therapeutic options	7
Corrigendum to “Cell cycle dysregulation in cancer” [Pharmacological Reviews 77 (2025) 100030]	7
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology	6
Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential	6
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction	6
Table of Contents	6
Editorial Board	5
Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells	5
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease	5
Toward a paradigm shift: Oral agents and injectable drugs in the future of obesity management	5
Editorial Board	5