OOIR: Observatory of International Research

Papers

(The median citation count of Pharmacological Reviews is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	493
Table of Contents	305
Innovative therapeutics for renoprotection: Where we are	274
Neurobiological Mechanisms of Nicotine Reward and Aversion	178
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	119
Editorial Board	112
Review of Natural Language Processing in Pharmacology	110
The Nitrogen Mustards	107
L-Type Calcium Channel Blockers: A Potential Novel Therapeutic Approach to Drug Dependence	104
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	103
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	101
Table of Contents	99
Table of Contents	92
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	83
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	77
Table of Contents	75
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	74
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	71
Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems	68
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	68
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	65
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	65
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	64
Table of Contents	59
Asthma therapeutics: Past, present, and future	58

Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	57
The Hippo pathway: Organ size control and beyond	55
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	55
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	54
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	52
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	48
Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease	47
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	46
Nonhormonal Male Contraceptive Development—Strategies for Progress	44
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	44
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	44
Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?	43
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	42
Dopamine, Immunity, and Disease	41
Editorial Board	39
Neurobiology of the incubation of drug craving: An update	39
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	37
Analgesic Potential of Terpenes Derived from Cannabis sativa	36
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	35
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	32
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	32
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	31
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	29
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	29
Vitamin D and its analogs in immune system regulation	27
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	26
Animal Behavior in Psychedelic Research	26
The Development of Cannabinoids as Therapeutic Agents in the United States	25
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines	25
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	24
Table of Contents	23
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	23
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	23
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	21
α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials	20
Anticoagulants: From chance discovery to structure-based design	20
Table of Contents	20
Drugging dancing protein clouds: A close look at disorder-based drug design	20
Table of Contents	20
Adrenoceptor Desensitization: Current Understanding of Mechanisms	19
From bone sentinel to immune savant: Vitamin D and its receptor’s pharmacology	18
The Complement System: Biology, Pathology and Therapeutic Interventions	18
Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis	18
Analyzing lognormal data: A nonmathematical practical guide	17
Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance	17
Antipsychotics and dietary interventions: Pharmacodynamics, pharmacokinetics, and synergisms in therapy	17
International Union of Basic and Clinical Pharmacology CXV: The Class F of G Protein-Coupled Receptors	16
Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor	16
Pharmacological Approaches to Hearing Loss	16
International Union of Basic and Clinical Pharmacology. CXX. γ-Hydroxybutyrate protein targets in the mammalian brain—beyond classic receptors	16

Summing Up Pharmacological Reviews’ 75th Anniversary Year and a Look to the Future	15
Precision Medicine in Rheumatic Diseases: Unlocking the Potential of Antibody-Drug Conjugates	15
Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases	15
Drug-Drug Interactions and Synergy: From Pharmacological Models to Clinical Application	15
Pharmacological therapies for male infertility	14
Table of Contents	14
Editorial Board	14
Leveraging Lymphatic System Targeting in Systemic Lupus Erythematosus for Improved Clinical Outcomes	14
Pharmacology and Precision Medicine—Preparing for the Next Era in Clinical Medicine—Editorial	14
Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction	13
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels	13
Senotherapy for chronic lung disease	13
Inhaled Medicines: Past, Present, and Future	13
Changing Cerebral Blood Flow, Glucose Metabolism, and Dopamine Binding Through Transcranial Magnetic Stimulation: A Systematic Review of Transcranial Magnetic Stimulation-Positron Emission Tomography	12
Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust	12
A Chance to Grow and Excel as an Associate Editor of Pharmacological Reviews—Editorial	12
A 25-Year Journey as Author and Associate Editor of Pharmacological Reviews—Editorial	11
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies	10
Editorial Board	10
Multi- and polypharmacology of carbonic anhydrase inhibitors	10
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4	10
Fibroblasts—The emerging therapeutic target of the cardiovascular system?	10
Pharmacologic treatments for gastroparesis	9
International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors—Structures, functions, activators, and blockers	9
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials	9
Cyclic nucleotide phosphodiesterases as drug targets	9
Topically Applied Therapies for the Treatment of Skin Disease: Past, Present, and Future	9
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies	8
Ferroptosis and pathogenesis of neuritic plaques in Alzheimer disease	8
Bioactives from marine resources as natural health products: A review	8
Reversing the odds: Advanced and emerging therapeutic strategies for male infertility	7
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain	7
Cytochrome P450 Enzymes: The Old Pandora’s Box with an Ever-Growing Hope for Therapy Optimization and Drug Development—Editorial	7
Nitric Oxide Signaling and Regulation in the Cardiovascular System: Recent Advances	6
Announcement	6
Pharmacological treatment for metabolic dysfunction–associated steatotic liver disease and related disorders: Current and emerging therapeutic options	6
Table of Contents	6
Table of Contents	6
Corrigendum to “Cell cycle dysregulation in cancer” [Pharmacological Reviews 77 (2025) 100030]	6
Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential	5
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction	5
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology	5
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling	5
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease	5