OOIR: Observatory of International Research

Papers

(The median citation count of Pharmacological Reviews is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	338
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	318
Innovative therapeutics for renoprotection: Where we are	206
Neurobiological Mechanisms of Nicotine Reward and Aversion	140
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	126
Review of Natural Language Processing in Pharmacology	125
The Nitrogen Mustards	120
Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy	118
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	117
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	113
Table of Contents	100
Table of Contents	90
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	89
Table of Contents	87
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	84
Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems	80
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	80
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	79
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	78
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	78
Table of Contents	74
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	74
Asthma therapeutics: Past, present, and future	70
The Hippo pathway: Organ size control and beyond	64
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	63

Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease	59
miR-155 aberrant expression impairs tumor rejection due to its targeting of ICOSL and multiple pathways implicated in the anti-tumor response	57
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	56
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	55
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	50
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	49
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	47
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	47
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	47
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	46
Dopamine, Immunity, and Disease	44
Nonhormonal Male Contraceptive Development—Strategies for Progress	44
Neurobiology of the incubation of drug craving: An update	42
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	41
Editorial Board	41
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	37
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	36
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	36
Animal Behavior in Psychedelic Research	33
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	33
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	32
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	31
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	30
Vitamin D and its analogs in immune system regulation	29
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	29
Table of Contents	28
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	28
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	27
The Development of Cannabinoids as Therapeutic Agents in the United States	26
Harnessing multiomics technologies and machine learning for advancing personalized theranostic approaches in atherosclerosis	25
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	24
Erratum to “Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions” [Pharmacological Reviews 77 (2025) 100080]	24
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines	24
Anticoagulants: From chance discovery to structure-based design	23
Adrenoceptor Desensitization: Current Understanding of Mechanisms	23
Table of Contents	23
Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy	23
Drugging dancing protein clouds: A close look at disorder-based drug design	23
Table of Contents	23
α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials	22
Modeling lung transporters and their influence on inhaled drug disposition	21
The complement system: Biology, pathology, and therapeutic interventions	21
From bone sentinel to immune savant: Vitamin D and its receptor’s pharmacology	20
The evolution of lipid-lowering drugs in the management of cardiovascular disease risk: From the first cardiovascular disease risk–reducing therapies to the novel challenging strategies	19
Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance	19
Antipsychotics and dietary interventions: Pharmacodynamics, pharmacokinetics, and synergisms in therapy	18
International Union of Basic and Clinical Pharmacology. CXX. γ-Hydroxybutyrate protein targets in the mammalian brain—beyond classic receptors	18
Analyzing lognormal data: A nonmathematical practical guide	17
Precision Medicine in Rheumatic Diseases: Unlocking the Potential of Antibody-Drug Conjugates	17
Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases	17

Pharmacological Approaches to Hearing Loss	17
Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis	16
Summing Up Pharmacological Reviews’ 75th Anniversary Year and a Look to the Future	16
Drug-Drug Interactions and Synergy: From Pharmacological Models to Clinical Application	16
International Union of Basic and Clinical Pharmacology CXV: The Class F of G Protein-Coupled Receptors	16
Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor	16
Leveraging Lymphatic System Targeting in Systemic Lupus Erythematosus for Improved Clinical Outcomes	15
Table of Contents	14
Editorial Board	14
Pharmacology and Precision Medicine—Preparing for the Next Era in Clinical Medicine—Editorial	14
Changing Cerebral Blood Flow, Glucose Metabolism, and Dopamine Binding Through Transcranial Magnetic Stimulation: A Systematic Review of Transcranial Magnetic Stimulation-Positron Emission Tomography	12
Inhaled Medicines: Past, Present, and Future	12
Pharmacological therapies for male infertility	12
Senotherapy for chronic lung disease	12
Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction	12
A 25-Year Journey as Author and Associate Editor of Pharmacological Reviews—Editorial	11
Editorial Board	11
Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust	11
A Chance to Grow and Excel as an Associate Editor of Pharmacological Reviews—Editorial	11
Fibroblasts—The emerging therapeutic target of the cardiovascular system?	11
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies	10
Multi- and polypharmacology of carbonic anhydrase inhibitors	10
Topically Applied Therapies for the Treatment of Skin Disease: Past, Present, and Future	10
Pharmacologic treatments for gastroparesis	10
International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors—Structures, functions, activators, and blockers	9
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials	9
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4	9
Bioactives from marine resources as natural health products: A review	8
Ferroptosis and pathogenesis of neuritic plaques in Alzheimer disease	8
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies	8
Cyclic nucleotide phosphodiesterases as drug targets	8
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain	8
Corrigendum to “Cell cycle dysregulation in cancer” [Pharmacological Reviews 77 (2025) 100030]	7
Cytochrome P450 Enzymes: The Old Pandora’s Box with an Ever-Growing Hope for Therapy Optimization and Drug Development—Editorial	7
Table of Contents	7
Reversing the odds: Advanced and emerging therapeutic strategies for male infertility	7
Nitric Oxide Signaling and Regulation in the Cardiovascular System: Recent Advances	6
Pharmacological treatment for metabolic dysfunction–associated steatotic liver disease and related disorders: Current and emerging therapeutic options	6
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology	5
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling	5
Physiological functions and pharmacological targeting of transient receptor potential channels	5
Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system	5
Table of Contents	5
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction	4
Toward a paradigm shift: Oral agents and injectable drugs in the future of obesity management	4
Editorial Board	4
Editorial Board	4
Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging	4
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease	4
Waking up to the evidence of pharmacological treatments used to manage sleep disorders in people with dementia and mild cognitive impairment – a scoping review.	4