OOIR: Observatory of International Research

Papers

(The median citation count of Pharmacological Reviews is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies	386
Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options	374
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels	247
Is Oxytocin “Nature’s Medicine”?	198
RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges	192
Rescuing the Last-Line Polymyxins: Achievements and Challenges	174
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development	160
Subcellular Organization of the cAMP Signaling Pathway	143
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function	136
The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway	134
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials	117
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms	108
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics	98
Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology	98
Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950	89
Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time	86
Sex- and Gender-Based Pharmacological Response to Drugs	86
On the Clinical Pharmacology of Reactive Oxygen Species	72
International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update	68
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	68
Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?	66
Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches	63
International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function	62
Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species	61
Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review	61

Unlocking G-Quadruplexes as Antiviral Targets	61
Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies	60
E1 Enzymes as Therapeutic Targets in Cancer	58
Dopamine, Immunity, and Disease	56
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications	56
Aldo-Keto Reductases and Cancer Drug Resistance	55
Inhaled Medicines: Past, Present, and Future	46
Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury	44
Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors	41
Therapeutics in the Pipeline Targetingα-Synuclein for Parkinson's Disease	41
Neurobiological Mechanisms of Nicotine Reward and Aversion	40
Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications	39
Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development	39
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain	38
Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain	36
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors	34
The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target	33
International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors	33
Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders	32
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	31
The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein	31
Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning	31
Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling	30
Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation	28
International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E₂Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific	27
Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight	27
Cognitive Impairment in Older Adults and Therapeutic Strategies	24
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	24
Analgesic Potential of Terpenes Derived fromCannabis sativa	23
Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect	23
Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development—Current State-of-the-Art and Future Perspectives	23
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction	22
Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells	22
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution	21
The Emerging Role of the Innate Immune Response in Idiosyncratic Drug Reactions	19
Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting	19
Newly Developed Targeted Therapies Against the Androgen Receptor in Triple-Negative Breast Cancer: A Review	19
Pharmacology of Heparin and Related Drugs: An Update	19
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease	19
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	19
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	18
Pharmacogenomics: Driving Personalized Medicine	16
β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives	15
Viral G Protein–Coupled Receptors: Attractive Targets for Herpesvirus-Associated Diseases	15
Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders	15
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	14
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years	14
Understanding the Neural Mechanisms of General Anesthesia from Interaction with Sleep–Wake State: A Decade of Discovery	14
α6-Containing GABA_AReceptors: Functional Roles and Therapeutic Potentials	14
The Nitrogen Mustards	14

New Technologies Bloom Together for Bettering Cancer Drug Conjugates	14
Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection	14
Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies	14