OOIR: Observatory of International Research

Papers

(The median citation count of Pharmacological Reviews is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	285
Innovative therapeutics for renoprotection: Where we are	221
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	208
Review of Natural Language Processing in Pharmacology	171
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	144
Reimagining pharmacology education	135
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	133
Table of Contents	131
Table of Contents	129
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	123
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	121
Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy	112
Mitochondrial metabolism as a pharmacological target for cancer therapeutics	110
Table of Contents	96
Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems	90
Targeting of kinases to treat neurodegenerative diseases	88
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	88
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	75
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	73
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	72
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	72
The Skeletal Connectome: From Molecular Circuitry to Systemic Network Medicine	71
Pharmacology and therapeutics of bile acid synthesis and modification enzymes in metabolic diseases	71
Table of Contents	69
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	69

Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	68
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	64
miR-155 aberrant expression impairs tumor rejection because of its targeting of ICOSL and multiple pathways implicated in the antitumor response	64
Asthma therapeutics: Past, present, and future	64
The Hippo pathway: Organ size control and beyond	62
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	60
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	60
Nonhormonal Male Contraceptive Development—Strategies for Progress	56
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	56
Neurobiology of the incubation of drug craving: An update	55
From neuroimmune circuits to targeted therapy of chronic pruritus	55
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	54
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	53
Kv7 channels as pharmacological targets for CNS diseases	49
Editorial Board	47
Dopamine, Immunity, and Disease	47
Disulfidptosis: A novel cell death mechanism with pathological significance and therapeutic potential in diseases	47
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	45
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	43
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	41
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	39
International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors	38
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	37
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	37
Animal Behavior in Psychedelic Research	37
Vitamin D and its analogs in immune system regulation	34
Table of Contents	33
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	31
Erratum to “Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions” [Pharmacological Reviews 77 (2025) 100080]	29
Harnessing multiomics technologies and machine learning for advancing personalized theranostic approaches in atherosclerosis	29
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	28
The Development of Cannabinoids as Therapeutic Agents in the United States	28
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	27
Table of Contents	26
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	26
Drugging dancing protein clouds: A close look at disorder-based drug design	26
Modeling lung transporters and their influence on inhaled drug disposition	26
Epithelial cells in chronic obstructive pulmonary disease exacerbations: Targets for lung repair	26
Adrenoceptor Desensitization: Current Understanding of Mechanisms	25
Table of Contents	25
Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy	24
The complement system: Biology, pathology, and therapeutic interventions	24
Carbon dots for drug delivery: Insights into their potential in nanopharmacology	24
Synergistic combinations of antimicrobial peptides and conventional antibiotics: A strategy to delay resistance emergence in World Health Organization priority bacteria	23
Anticoagulants: From chance discovery to structure-based design	23
From bone sentinel to immune savant: Vitamin D and its receptor’s pharmacology	23
Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis	23
International Union of Basic and Clinical Pharmacology. CXX. γ-Hydroxybutyrate protein targets in the mammalian brain—beyond classic receptors	23
Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance	23
Precision Medicine in Rheumatic Diseases: Unlocking the Potential of Antibody-Drug Conjugates	22

Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor	22
The evolution of lipid-lowering drugs in the management of cardiovascular disease risk: From the first cardiovascular disease risk–reducing therapies to the novel challenging strategies	22
Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases	20
International Union of Basic and Clinical Pharmacology CXV: The Class F of G Protein-Coupled Receptors	19
Pharmacological Approaches to Hearing Loss	19
Analyzing lognormal data: A nonmathematical practical guide	18
Friend or foe? Glial–vascular interactions in health and neurodegenerative disease	18
Drug-Drug Interactions and Synergy: From Pharmacological Models to Clinical Application	17
Antipsychotics and dietary interventions: Pharmacodynamics, pharmacokinetics, and synergisms in therapy	17
Pharmacological therapies for male infertility	17
Summing Up Pharmacological Reviews’ 75th Anniversary Year and a Look to the Future	17
Leveraging Lymphatic System Targeting in Systemic Lupus Erythematosus for Improved Clinical Outcomes	17
Changing Cerebral Blood Flow, Glucose Metabolism, and Dopamine Binding Through Transcranial Magnetic Stimulation: A Systematic Review of Transcranial Magnetic Stimulation-Positron Emission Tomography	16
Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction	16
Pharmacology and Precision Medicine—Preparing for the Next Era in Clinical Medicine—Editorial	16
Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust	15
A Chance to Grow and Excel as an Associate Editor of Pharmacological Reviews—Editorial	15
Editorial Board	15
Senotherapy for chronic lung disease	15
A 25-Year Journey as Author and Associate Editor of Pharmacological Reviews—Editorial	15
Pharmacologic treatments for gastroparesis	14
Fibroblasts—The emerging therapeutic target of the cardiovascular system?	14
Topically Applied Therapies for the Treatment of Skin Disease: Past, Present, and Future	14
Thrombin generation and the pharmacodynamics of parenteral anticoagulants	14
Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies	13
Translational medications development for methamphetamine use disorder: A systematic review of preclinical, human laboratory, and clinical research	13
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4	12
Multi- and polypharmacology of carbonic anhydrase inhibitors	12
International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors—Structures, functions, activators, and blockers	12
Cyclic nucleotide phosphodiesterases as drug targets	12
Reversing the odds: Advanced and emerging therapeutic strategies for male infertility	11
Platelet activation, aspirin, and cancer: From basic science to clinical trials	11
Corrigendum to “Cell cycle dysregulation in cancer” [Pharmacological Reviews 77 (2025) 100030]	11
Cytochrome P450 Enzymes: The Old Pandora’s Box with an Ever-Growing Hope for Therapy Optimization and Drug Development—Editorial	11
Ferroptosis and pathogenesis of neuritic plaques in Alzheimer disease	11
From physiopathology to treatment of familial hypercholesterolemia: Existing and emerging pharmacotherapies	11
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies	11
Bioactives from marine resources as natural health products: A review	11
Pharmacological modulation of the blood-brain barrier: Mechanisms, therapeutic strategies, and emerging technologies	10
Nitric Oxide Signaling and Regulation in the Cardiovascular System: Recent Advances	10
The neuropharmacological basis of placebo analgesia: Mechanisms and clinical applications in the context of chronic pain	10
Pharmacological treatment for metabolic dysfunction–associated steatotic liver disease and related disorders: Current and emerging therapeutic options	10
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling	10
Links between COVID-19, long COVID, and neurodegeneration: The role of glycosphingolipids	10
Table of Contents	10
Physiological functions and pharmacological targeting of transient receptor potential channels	10
Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system	9
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction	9
Erratum to “Edaravone: Advances on cytoprotective effects, pharmacological properties, and mechanisms of action” [Pharmacological Reviews 78 (2025) 100101]	9
Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease	9
Editorial Board	8
Waking up to the evidence of pharmacological treatments used to manage sleep disorders in people with dementia and mild cognitive impairment—A scoping review	8
Editorial Board	8
Toward a paradigm shift: Oral agents and injectable drugs in the future of obesity management	8
International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology	8
Immunomodulatory effects of calorie restriction and its mimetics: A new potential therapeutic approach for autoimmune diseases	7
Hunting Gremlins: GREM1 as a New Therapeutic Target for Multiple Diseases Including Glaucoma	7
Application of Kirchhoff’s Laws to pharmacologic and pharmacokinetic analyses	7
Genetic therapies for neurological diseases	7