OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reviews is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	338
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	318
Innovative therapeutics for renoprotection: Where we are	206
Neurobiological Mechanisms of Nicotine Reward and Aversion	140
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	126
Review of Natural Language Processing in Pharmacology	125
The Nitrogen Mustards	120
Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy	118
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	117
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	113
Table of Contents	100
Table of Contents	90
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	89
Table of Contents	87
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	84
Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems	80
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	80
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	79
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	78
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	78
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	74
Table of Contents	74
Asthma therapeutics: Past, present, and future	70
The Hippo pathway: Organ size control and beyond	64
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	63

Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease	59
miR-155 aberrant expression impairs tumor rejection due to its targeting of ICOSL and multiple pathways implicated in the anti-tumor response	57
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	56
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	55
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	50
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	49
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	47
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	47
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	47
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	46
Dopamine, Immunity, and Disease	44
Nonhormonal Male Contraceptive Development—Strategies for Progress	44
Neurobiology of the incubation of drug craving: An update	42
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	41
Editorial Board	41
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	37
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	36
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	36
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	33
Animal Behavior in Psychedelic Research	33
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	32
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	31
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	30
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	29
Vitamin D and its analogs in immune system regulation	29
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	28
Table of Contents	28
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	27
The Development of Cannabinoids as Therapeutic Agents in the United States	26
Harnessing multiomics technologies and machine learning for advancing personalized theranostic approaches in atherosclerosis	25
Erratum to “Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions” [Pharmacological Reviews 77 (2025) 100080]	24
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines	24
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	24
Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy	23
Drugging dancing protein clouds: A close look at disorder-based drug design	23
Table of Contents	23
Anticoagulants: From chance discovery to structure-based design	23
Adrenoceptor Desensitization: Current Understanding of Mechanisms	23
Table of Contents	23