OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reviews is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	418
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	412
Innovative therapeutics for renoprotection: Where we are	252
Reimagining pharmacology education	201
The Nitrogen Mustards	178
Review of Natural Language Processing in Pharmacology	155
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	146
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	136
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	123
Table of Contents	119
Table of Contents	118
Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy	110
The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	106
Table of Contents	106
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	100
Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems	100
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	90
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	79
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	78
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	74
Targeting of kinases to treat neurodegenerative diseases	69
Pharmacology and therapeutics of bile acid synthesis and modification enzymes in metabolic diseases	69
Table of Contents	67
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	66
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	65

miR-155 aberrant expression impairs tumor rejection because of its targeting of ICOSL and multiple pathways implicated in the antitumor response	60
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	59
Asthma therapeutics: Past, present, and future	58
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	57
The Hippo pathway: Organ size control and beyond	54
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	54
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	53
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	52
Nonhormonal Male Contraceptive Development—Strategies for Progress	52
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	51
From neuroimmune circuits to targeted therapy of chronic pruritus	51
Neurobiology of the incubation of drug craving: An update	50
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	50
Dopamine, Immunity, and Disease	49
Disulfidptosis: A novel cell death mechanism with pathological significance and therapeutic potential in diseases	48
Editorial Board	47
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	44
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	43
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	43
Animal Behavior in Psychedelic Research	42
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	42
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	42
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	41
Vitamin D and its analogs in immune system regulation	40
Table of Contents	37
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	34
Erratum to “Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions” [Pharmacological Reviews 77 (2025) 100080]	33
The Development of Cannabinoids as Therapeutic Agents in the United States	33
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	33
Epithelial cells in chronic obstructive pulmonary disease exacerbations: Targets for lung repair	32
Harnessing multiomics technologies and machine learning for advancing personalized theranostic approaches in atherosclerosis	32
Drugging dancing protein clouds: A close look at disorder-based drug design	30
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	30
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	30
Table of Contents	28
Table of Contents	28
Anticoagulants: From chance discovery to structure-based design	27
The complement system: Biology, pathology, and therapeutic interventions	26
Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy	25
Synergistic combinations of antimicrobial peptides and conventional antibiotics: A strategy to delay resistance emergence in World Health Organization priority bacteria	24
Adrenoceptor Desensitization: Current Understanding of Mechanisms	24
Modeling lung transporters and their influence on inhaled drug disposition	23
Carbon dots for drug delivery: Insights into their potential in nanopharmacology	23