OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reviews is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Seventy-Five Years of Interactions: The Department of Physiology and Pharmacology at Karolinska Institutet and Pharmacological Reviews	686
Table of Contents	460
Neurobiological Mechanisms of Nicotine Reward and Aversion	285
The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes	246
Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review	159
L-Type Calcium Channel Blockers: A Potential Novel Therapeutic Approach to Drug Dependence	118
Editorial Board	109
Review of Natural Language Processing in Pharmacology	104
The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics	103
The Nitrogen Mustards	96
Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies	96
Carbonic anhydrase inhibitors: “Old” drugs with new potential in unexpected areas	96
Table of Contents	93
Table of Contents	90
The endocannabinoidomes: pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets	89
Table of Contents	87
Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling	85
Pharmaceutical Perspectives on Oligonucleotide Therapeutics and Delivery Systems	78
Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes	77
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins	76
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023	74
Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review	66
Table of Contents	65
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer	65
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry	64

Therapeutic Potential of Targeting Prokineticin Receptors in Diseases	63
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response	62
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications	59
Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease	59
Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism	57
The Hippo pathway: Organ size control and beyond	57
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy	56
Neurobiology of the incubation of drug craving: An update	52
Sulfotransferase 2B1b, Sterol Sulfonation, and Disease	50
Dopamine, Immunity, and Disease	49
Corrigendum to “International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes” [Pharmacologic	48
Nonhormonal Male Contraceptive Development—Strategies for Progress	48
Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?	46
Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood	42
Editorial Board	42
Pharmacological Reviews’ 75th Year Anniversary: Past and Future—Editorial	41
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease	41
Extracellular Vesicle Heterogeneity and Its Impact for Regenerative Medicine Applications	40
Analgesic Potential of Terpenes Derived from Cannabis sativa	40
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks	39
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming	38
Conotoxins Targeting Voltage-Gated Sodium Ion Channels	38
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting	37
Animal Behavior in Psychedelic Research	35
Vitamin D and its analogs in immune system regulation	34
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions	33
The Development of Cannabinoids as Therapeutic Agents in the United States	32
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines	32
Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics	31
Editorial Board	30
Table of Contents	30
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity	26
International Union of Basic and Clinical Pharmacology. CXVIII. Update on the nomenclature for atypical chemokine receptors, including ACKR5	26
Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment	24
Table of Contents	23
Drugging dancing protein clouds: A close look at disorder-based drug design	23