OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Reviews is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Corrigendum for Lutsenko et al., volume 105, 2025, p. 441–491	421
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca²⁺ signaling	415
SIRT7: the seventh key to unlocking the mystery of aging	377
Making a good egg: human oocyte health, aging, and in vitro development	306
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries	302
Implications of the NADase CD38 in COVID pathophysiology	247
Hacking the functions of sleep: Non-invasive approaches to stimulate sleep neurophysiology	238
A comprehensive review of the neuroscience of ingestion: the physiological control of eating: signals, neurons, and networks	232
Glycerolipid Cycling in Thermogenesis, Energy Homeostasis, Signaling, and Diseases	203
Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes	194
Systematic reviews for basic scientists: a different beast	194
Sensing molecular carbon dioxide: a translational focus for respiratory disease	191
Programmed cell death and tissue regeneration: a link that should be resolved	190
Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms	187
The physiopathology of brain-derived neurotrophic factor	161
Rho GTPase signaling in cancer progression and dissemination	160
Contribution of adaptive immunity to human COPD and experimental models of emphysema	150
Understanding COVID-19 susceptibility and presentation based on its underlying physiology	147
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion	143
Immunotherapy for atherosclerosis	139
Mitochondrial calcium exchange in physiology and disease	139
Molecular dissection of the role of ACE2 in glucose homeostasis	135
NETosis creates a link between diabetes and Long COVID	132
A primer on obesity-related cardiomyopathy	132
Complex physiology and clinical implications of time-restricted eating	131

The physiological control of eating: signals, neurons, and networks	125
The enteric nervous system	121
Calcium-release channels: structure and function of IP₃ receptors and ryanodine receptors	110
Genome-wide association studies of cardiovascular disease	108
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs	104
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives	103
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms	102
Redox signaling in the pancreas in health and disease	93
The human placenta and its role in reproductive outcomes revisited	93
The molecular athlete: exercise physiology from mechanisms to medals	91
Determinants, maintenance, and function of organellar pH	89
How development sculpts hippocampal circuits and function	88
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases	85
Is Notch1 a neglected vascular mechanosensor?	81
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes	80
Bioenergetics: the evolutionary basis of progressive kidney disease	80
Recent advances in alcohol metabolism: from the gut to the brain	76
Gravity, Microgravity and Artificial Gravity: Physiological Effects, Implementation and Applications	76
Principles of odor coding in vertebrates and artificial chemosensory systems	75
NADPH oxidases: redox regulation of cell homeostasis and disease	75
Community-acquired bacterial coinfections and COVID-19	74
Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases	72
Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions	71
Physiologic mechanisms underlying polycystic kidney disease	69
Wonder of wonders, miracle of miracles: the unprecedented speed of COVID-19 science	68
Fluid transport in the brain	67
The elusive cephalic phase insulin response: triggers, mechanisms, and functions	66
Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection	65
Transforming the concept of connectivity: unveiling tunneling nanotube biology and their roles in brain development and neurodegeneration	65
Pathophysiology of syncope: current concepts and their development	64
Ca²⁺ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract	63
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology	62
Mechanisms of SARS-CoV-2-associated anosmia	62
Navigating the multifaceted intricacies of the Na⁺-Cl⁻ cotransporter, a highly regulated key effector in the control of hydromineral homeostasis	61
Trained immunity: adaptation within innate immune mechanisms	61
The physiological functions of human peroxisomes	60
Biomarkers of aging: from molecules and surrogates to physiology and function	57
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions	54
Altered islet prohormone processing: a cause or consequence of diabetes?	54
Cannabinoid treatments in epilepsy and seizure disorders	52
Brain structural networks underlying language	52
Sperm bauplan and function and underlying processes of sperm formation and selection	50
Phosphodiesterase in heart and vessels: from physiology to diseases	50
Membrane adhesion junctions regulate airway smooth muscle phenotype and function	49
Protease-activated receptors in health and disease	49
Salivary gland function, development, and regeneration	48
The neurobiology of parenting and infant-evoked aggression	46
Human temperature regulation under heat stress in health, disease, and injury	43
Cysteine-based redox sensors in the cardiovascular system: from identification to physiology and drug discovery	42
Hepatic glucagon action: beyond glucose mobilization	40

Extracellular vesicles and the lung: from disease pathogenesis to biomarkers and treatments	39
Uterine fibroids	37
The osteocyte as a signaling cell	36
Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis	36
Sympathetic circuits regulating hepatic glucose metabolism: where we stand	35
Deconstructing the GWAS library: next-generation GWAS	34
Multiscale structure and function of the aortic valve apparatus	34
Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches	33
Vascular mechanotransduction	33
Examining the shared etiology of psychopathology with genome-wide association studies	32
The multiple roles of salt-inducible kinases in regulating physiology	32
Windows into stress: a glimpse at emerging roles for CRH^PVN neurons	31
Physiological basis for xenotransplantation from genetically modified pigs to humans	31
Lymphatic vessels in cancer	31
Mechanisms and physiological implications of cooperative gating of clustered ion channels	30
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology	30
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training	29
Psychophysiological foundations of human physical activity behavior and motivation: theories, systems, mechanisms, evolution, and genetics	28
Neuropathological links between T2DM and LOAD: systematic review and meta-analysis	28
Corrigendum for Eisner et al., volume 103, 2023, p. 2767–2845	28
Mitochondrial quality control in health and in Parkinson’s disease	27