OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Reviews is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
SIRT7: the seventh key to unlocking the mystery of aging	521
Corrigendum for Lutsenko et al., volume 105, 2025, p. 441–491	471
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca²⁺ signaling	367
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries	313
Making a good egg: human oocyte health, aging, and in vitro development	304
Central control of gastrointestinal functions in health and disease	302
Editorial Board	260
Hacking the functions of sleep: noninvasive approaches to stimulate sleep neurophysiology	239
Glycerolipid Cycling in Thermogenesis, Energy Homeostasis, Signaling, and Diseases	225
Systematic reviews for basic scientists: a different beast	211
Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes	209
Magnetosensation - the unsolved mystery	192
Contribution of adaptive immunity to human COPD and experimental models of emphysema	184
The physiopathology of brain-derived neurotrophic factor	181
Metabolic adaptations in cancer progression	181
Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms	180
Sensing molecular carbon dioxide: a translational focus for respiratory disease	168
Programmed cell death and tissue regeneration: a link that should be resolved	164
Understanding COVID-19 susceptibility and presentation based on its underlying physiology	160
Molecular systems, human noncoding sequence variants, and blood pressure	155
Immunotherapy for atherosclerosis	154
Transitional Cell States at the Crossroad of Development, Disease, and Repair-Regeneration	153
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion	145
Molecular dissection of the role of ACE2 in glucose homeostasis	129
NETosis creates a link between diabetes and Long COVID	124

The enteric nervous system	121
Complex physiology and clinical implications of time-restricted eating	120
Genome-wide association studies of cardiovascular disease	109
The Cell with Many Faces: Lung Macrophage Plasticity and Function in Response to Environmental and Pathogenic Insults	108
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs	107
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives	106
Angiocrine and pericrine signaling: how endothelial cells and pericytes drive cancer progression and therapy resistance	106
The molecular athlete: exercise physiology from mechanisms to medals	104
Redox signaling in the pancreas in health and disease	102
The human placenta and its role in reproductive outcomes revisited	98
Determinants, maintenance, and function of organellar pH	96
Is Notch1 a neglected vascular mechanosensor?	94
Bioenergetics: the evolutionary basis of progressive kidney disease	94
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases	92
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes	89
Recent advances in alcohol metabolism: from the gut to the brain	86
NADPH oxidases: redox regulation of cell homeostasis and disease	83
Gravity, microgravity, and artificial gravity: physiological effects, implementation, and applications	80
Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection	76
Community-acquired bacterial coinfections and COVID-19	75
Transforming the concept of connectivity: unveiling tunneling nanotube biology and their roles in brain development and neurodegeneration	72
Wonder of wonders, miracle of miracles: the unprecedented speed of COVID-19 science	71
The elusive cephalic phase insulin response: triggers, mechanisms, and functions	70
Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions	69
Physiologic mechanisms underlying polycystic kidney disease	66
Mechanisms of SARS-CoV-2-associated anosmia	65
Frontiers in the physiology of male pattern androgenetic alopecia: beyond the androgen horizon	64
Navigating the multifaceted intricacies of the Na⁺-Cl⁻ cotransporter, a highly regulated key effector in the control of hydromineral homeostasis	63
Pathophysiology of syncope: current concepts and their development	63
Ca²⁺ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract	61
Trained immunity: adaptation within innate immune mechanisms	61
The physiological functions of human peroxisomes	59
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology	58
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions	57
The nonexcitable smooth muscle: Remodeling the smooth muscle ion transport toolkit in disease	56
An umbrella review of systematic reviews of the impact of wrist-worn wearables on health outcomes	56
Crossroads between autoimmunity and cancer: underlying mechanisms and clinical implications	56
Brain structural networks underlying language	55
Biomarkers of aging: from molecules and surrogates to physiology and function	55
Cholangiocyte Biology in Primary Sclerosing Cholangitis and Other Cholangiopathies: Pathogenesis, Clinical Insights, and Experimental Tools	53
Cannabinoid treatments in epilepsy and seizure disorders	53
Phosphodiesterase in heart and vessels: from physiology to diseases	50
Membrane adhesion junctions regulate airway smooth muscle phenotype and function	47
Protease-activated receptors in health and disease	45
Human temperature regulation under heat stress in health, disease, and injury	43
The neurobiology of parenting and infant-evoked aggression	43
Salivary gland function, development, and regeneration	42
Sympathetic circuits regulating hepatic glucose metabolism: where we stand	41
Deconstructing the GWAS library: next-generation GWAS	41
Extracellular vesicles and the lung: from disease pathogenesis to biomarkers and treatments	41

Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis	41
Hepatic glucagon action: beyond glucose mobilization	40
Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches	38
Multiscale structure and function of the aortic valve apparatus	35
Cysteine-based redox sensors in the cardiovascular system: from identification to physiology and drug discovery	35
Uterine fibroids	35
Vascular mechanotransduction	35
Windows into stress: a glimpse at emerging roles for CRH^PVN neurons	34
The multiple roles of salt-inducible kinases in regulating physiology	33
Examining the shared etiology of psychopathology with genome-wide association studies	32
Physiological basis for xenotransplantation from genetically modified pigs to humans	32
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology	31
Lymphatic vessels in cancer	31
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training	29
Mechanisms and physiological implications of cooperative gating of clustered ion channels	29
Psychophysiological foundations of human physical activity behavior and motivation: theories, systems, mechanisms, evolution, and genetics	28
Corrigendum for Eisner et al., volume 103, 2023, p. 2767–2845	28
Neuropathological links between T2DM and LOAD: systematic review and meta-analysis	28
Acid-sensing ion channels: structure, function, pharmacology, and clinical significance	28
The ion channels of endomembranes	27
Mitochondrial quality control in health and in Parkinson’s disease	27
Reversal theory as a complementary perspective on moment-to-moment variations in motivation for physical activity	27
A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise	27
Physiology of the tongue with emphasis on taste transduction	27