OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Reviews is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca²⁺ signaling	589
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries	366
Making a good egg: human oocyte health, aging, and in vitro development	338
SIRT7: the seventh key to unlocking the mystery of aging	323
Implications of the NADase CD38 in COVID pathophysiology	320
Systematic reviews for basic scientists: a different beast	259
A comprehensive review of the neuroscience of ingestion: the physiological control of eating: signals, neurons, and networks	256
Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes	223
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation	192
Contribution of adaptive immunity to human COPD and experimental models of emphysema	191
Sensing molecular carbon dioxide - a translational focus for respiratory disease	186
Sodium channelopathies of skeletal muscle and brain	175
Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms	166
The physiopathology of brain-derived neurotrophic factor	165
Rho GTPase signaling in cancer progression and dissemination	164
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion	153
Immunotherapy for atherosclerosis	151
Understanding COVID-19 susceptibility and presentation based on its underlying physiology	137
Mitochondrial calcium exchange in physiology and disease	123
A primer on obesity-related cardiomyopathy	121
Molecular dissection of the role of ACE2 in glucose homeostasis	117
Complex physiology and clinical implications of time-restricted eating	117
Calcium-release channels: structure and function of IP₃ receptors and ryanodine receptors	114
The physiological control of eating: signals, neurons, and networks	108
The enteric nervous system	107

NETosis creates a link between diabetes and Long COVID	106
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs	105
Genome-wide association studies of cardiovascular disease	105
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives	103
How development sculpts hippocampal circuits and function	98
Redox signaling in the pancreas in health and disease	96
Determinants, maintenance, and function of organellar pH	95
The molecular athlete: exercise physiology from mechanisms to medals	94
Angiocrine and Pericrine Signaling: How Endothelial Cells and Pericytes Drive Cancer Progression and Therapy Resistance	92
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms	91
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases	89
Bioenergetics: the evolutionary basis of progressive kidney disease	88
Is Notch1 a neglected vascular mechanosensor?	82
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes	81
NADPH oxidases: redox regulation of cell homeostasis and disease	80
Principles of odor coding in vertebrates and artificial chemosensory systems	79
In celebration of the 100th anniversary of Physiological Reviews	76
Physiologic mechanisms underlying polycystic kidney disease	73
Community-acquired bacterial coinfections and COVID-19	69
Wonder of wonders, miracle of miracles: the unprecedented speed of COVID-19 science	69
Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection	68
Transforming the concept of connectivity: unveiling tunneling nanotube biology and their roles in brain development and neurodegeneration	67
Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases	63
The elusive cephalic phase insulin response: triggers, mechanisms, and functions	62
Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions	62
Fluid transport in the brain	61
Navigating the multifaceted intricacies of the Na⁺-Cl⁻ cotransporter, a highly regulated key effector in the control of hydromineral homeostasis	60
Pathophysiology of syncope: current concepts and their development	59
Frontiers in the physiology of male pattern androgenetic alopecia: Beyond the androgen horizon	59
Trained immunity: adaptation within innate immune mechanisms	58
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology	58
The physiological functions of human peroxisomes	57
Exercise under heat stress: thermoregulation, hydration, performance implications, and mitigation strategies	54
Mechanisms of SARS-CoV-2-associated anosmia	53
Ca²⁺ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract	52
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions	47
Altered islet prohormone processing: a cause or consequence of diabetes?	47
Biomarkers of aging: from molecules and surrogates to physiology and function	47
Phosphodiesterase in heart and vessels: from physiology to diseases	46
Cannabinoid treatments in epilepsy and seizure disorders	46
CD38 in the age of COVID-19: a medical perspective	46
Membrane adhesion junctions regulate airway smooth muscle phenotype and function	45
Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema	45
Protease-activated receptors in health and disease	44
The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas	43
Sperm bauplan and function and underlying processes of sperm formation and selection	43
The neurobiology of parenting and infant-evoked aggression	42
Salivary gland function, development, and regeneration	42
Human temperature regulation under heat stress in health, disease, and injury	41
Hepatic glucagon action: beyond glucose mobilization	40

Sympathetic circuits regulating hepatic glucose metabolism: where we stand	39
Extracellular vesicles and the lung: from disease pathogenesis to biomarkers and treatments	39
Multiscale structure and function of the aortic valve apparatus	39
Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches	38
The osteocyte as a signaling cell	37
Vascular mechanotransduction	37
Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis	36
Windows into stress: a glimpse at emerging roles for CRH^PVN neurons	35
Examining the shared etiology of psychopathology with genome-wide association studies	34
Physiological basis for xenotransplantation from genetically modified pigs to humans	32
The multiple roles of salt-inducible kinases in regulating physiology	32
Lymphatic vessels in cancer	30
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology	30
Energy metabolism design of the striated muscle cell	30
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training	29
Mechanisms and physiological implications of cooperative gating of clustered ion channels	29
Corrigendum for Eisner et al., volume 103, 2023, p. 2767–2845	28
Mitochondrial quality control in health and in Parkinson’s disease	26
Neuropathological links between T2DM and LOAD: systematic review and meta-analysis	26
Psychophysiological foundations of human physical activity behavior and motivation: theories, systems, mechanisms, evolution, and genetics	26
A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise	26