OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Reviews is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca²⁺ signaling	559
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries	481
Making a good egg: human oocyte health, aging, and in vitro development	340
SIRT7: the seventh key to unlocking the mystery of aging	327
Implications of the NADase CD38 in COVID pathophysiology	300
Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes	297
Systematic reviews for basic scientists: a different beast	295
A comprehensive review of the neuroscience of ingestion: the physiological control of eating: signals, neurons, and networks	269
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation	265
Regulation and metabolic functions of mTORC1 and mTORC2	247
Contribution of adaptive immunity to human COPD and experimental models of emphysema	237
Rho GTPase signaling in cancer progression and dissemination	222
Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms	208
The complexity of Alzheimer’s disease: an evolving puzzle	194
Sodium channelopathies of skeletal muscle and brain	171
Understanding COVID-19 susceptibility and presentation based on its underlying physiology	170
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion	169
Immunotherapy for atherosclerosis	167
Mitochondrial calcium exchange in physiology and disease	155
Brain mechanisms of insomnia: new perspectives on causes and consequences	155
NETosis creates a link between diabetes and Long COVID	153
A primer on obesity-related cardiomyopathy	149
Calcium-release channels: structure and function of IP₃ receptors and ryanodine receptors	135
The enteric nervous system	135
The physiological control of eating: signals, neurons, and networks	124

Complex physiology and clinical implications of time-restricted eating	123
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives	113
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs	113
Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior	110
Genome-wide association studies of cardiovascular disease	109
How development sculpts hippocampal circuits and function	103
Redox signaling in the pancreas in health and disease	98
Determinants, maintenance, and function of organellar pH	96
The molecular athlete: exercise physiology from mechanisms to medals	93
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms	92
Bone metastasis: mechanisms, therapies, and biomarkers	92
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases	90
Bioenergetics: the evolutionary basis of progressive kidney disease	89
Is Notch1 a neglected vascular mechanosensor?	88
G protein-coupled receptor-G protein interactions: a single-molecule perspective	85
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes	85
Principles of odor coding in vertebrates and artificial chemosensory systems	83
Community-acquired bacterial coinfections and COVID-19	82
In celebration of the 100th anniversary of Physiological Reviews	82
Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection	79
Wonder of wonders, miracle of miracles: the unprecedented speed of COVID-19 science	79
The elusive cephalic phase insulin response: triggers, mechanisms, and functions	77
Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions	76
Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases	75
Navigating the multifaceted intricacies of the Na⁺-Cl⁻ cotransporter, a highly regulated key effector in the control of hydromineral homeostasis	75
Fluid transport in the brain	75
Pathophysiology of syncope: current concepts and their development	73
Mechanisms of SARS-CoV-2-associated anosmia	71
Ca²⁺ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract	65
The physiological functions of human peroxisomes	65
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology	65
Trained immunity: adaptation within innate immune mechanisms	60
Exercise under heat stress: thermoregulation, hydration, performance implications, and mitigation strategies	59
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions	59
Cannabinoid treatments in epilepsy and seizure disorders	58
Altered islet prohormone processing: a cause or consequence of diabetes?	56
Developmental origins of metabolic diseases	55
CD38 in the age of COVID-19: a medical perspective	54
Membrane adhesion junctions regulate airway smooth muscle phenotype and function	53
Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema	53
Sperm bauplan and function and underlying processes of sperm formation and selection	52
Phosphodiesterase in heart and vessels: from physiology to diseases	51
The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas	50
Protease-activated receptors in health and disease	50
The neurobiology of parenting and infant-evoked aggression	48
Salivary gland function, development, and regeneration	47
Human temperature regulation under heat stress in health, disease, and injury	45
Uterine Fibroids	44
Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches	42
Vascular mechanotransduction	41

Cysteine-based redox sensors in the cardiovascular system - from identification to physiology and drug discovery	41
The osteocyte as a signaling cell	41
Deconstructing the GWAS library - Next Generation GWAS	40
Sympathetic circuits regulating hepatic glucose metabolism: where we stand	40
Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis	39
Multiscale structure and function of the aortic valve apparatus	38
Hepatic glucagon action: beyond glucose mobilization	37
The multiple roles of salt-inducible kinases in regulating physiology	36
Physiological basis for xenotransplantation from genetically modified pigs to humans	36
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology	35
Examining the shared etiology of psychopathology with genome-wide association studies	35
Lymphatic vessels in cancer	32
Windows into stress: a glimpse at emerging roles for CRH^PVN neurons	31
Mechanisms and physiological implications of cooperative gating of clustered ion channels	30
Energy metabolism design of the striated muscle cell	30