OOIR: Observatory of International Research

Papers

(The median citation count of Physiological Reviews is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Corrigendum for Lutsenko et al., volume 105, 2025, p. 441–491	568
SIRT7: the seventh key to unlocking the mystery of aging	515
Making a good egg: human oocyte health, aging, and in vitro development	424
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca²⁺ signaling	356
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries	347
Impact of e-cigarette vaping on the immune system across the body	342
Editorial Board	308
Hacking the functions of sleep: noninvasive approaches to stimulate sleep neurophysiology	267
Central control of gastrointestinal functions in health and disease	250
Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease	248
Systematic reviews for basic scientists: a different beast	247
Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes	212
Glycerolipid Cycling in Thermogenesis, Energy Homeostasis, Signaling, and Diseases	212
The physiopathology of brain-derived neurotrophic factor	207
Metabolic adaptations in cancer progression	201
Contribution of adaptive immunity to human COPD and experimental models of emphysema	195
Sensing molecular carbon dioxide: a translational focus for respiratory disease	190
Programmed cell death and tissue regeneration: a link that should be resolved	181
Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms	177
Molecular systems, human noncoding sequence variants, and blood pressure	171
Immunotherapy for atherosclerosis	161
Transitional cell states at the crossroads of development, disease, and repair-regeneration	155
Understanding COVID-19 susceptibility and presentation based on its underlying physiology	134
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion	131
NETosis creates a link between diabetes and Long COVID	128

The enteric nervous system	120
Molecular dissection of the role of ACE2 in glucose homeostasis	120
Complex physiology and clinical implications of time-restricted eating	119
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives	118
The cell with many faces: lung macrophage plasticity and function in response to environmental and pathogenic insults	115
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs	115
Genome-wide association studies of cardiovascular disease	114
Determinants, maintenance, and function of organellar pH	109
Redox signaling in the pancreas in health and disease	109
Angiocrine and pericrine signaling: how endothelial cells and pericytes drive cancer progression and therapy resistance	104
The human placenta and its role in reproductive outcomes revisited	95
The molecular athlete: exercise physiology from mechanisms to medals	94
Is Notch1 a neglected vascular mechanosensor?	92
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes	88
Catecholamine metabolism revisited: From neurochemistry to integrative physiology and pathophysiology	85
Bioenergetics: the evolutionary basis of progressive kidney disease	84
The clinical pathophysiology of atrial fibrillation: outstanding questions from bedside to bench and back	83
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases	83
NADPH oxidases: redox regulation of cell homeostasis and disease	80
Recent advances in alcohol metabolism: from the gut to the brain	79
The lethal symbiont: exploring the pathophysiology of cancer	77
Community-acquired bacterial coinfections and COVID-19	76
Gravity, microgravity, and artificial gravity: physiological effects, implementation, and applications	76
The elusive cephalic phase insulin response: triggers, mechanisms, and functions	73
The alpha rhythm: from physiology to behavior	72
Transforming the concept of connectivity: unveiling tunneling nanotube biology and their roles in brain development and neurodegeneration	72
Physiologic mechanisms underlying polycystic kidney disease	72
Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions	71
Navigating the multifaceted intricacies of the Na⁺-Cl⁻ cotransporter, a highly regulated key effector in the control of hydromineral homeostasis	71
The physiological functions of human peroxisomes	67
Mechanisms of SARS-CoV-2-associated anosmia	67
Trained immunity: adaptation within innate immune mechanisms	66
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology	63
Ca²⁺ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract	62
Frontiers in the physiology of male pattern androgenetic alopecia: beyond the androgen horizon	61
Pathophysiology of syncope: current concepts and their development	58
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions	51
The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease	51
An umbrella review of systematic reviews of the impact of wrist-worn wearables on health outcomes	51
Biomarkers of aging: from molecules and surrogates to physiology and function	50
Crossroads between autoimmunity and cancer: underlying mechanisms and clinical implications	50
Unlocking the potential of circadian biology for cardiovascular health	49
Stomach at the crossroads: nuclear receptor signaling at the interface between what we are and what we eat	49
Cannabinoid treatments in epilepsy and seizure disorders	48
Brain structural networks underlying language	48
Phosphodiesterase in heart and vessels: from physiology to diseases	47
Membrane adhesion junctions regulate airway smooth muscle phenotype and function	46
Editorial Board	46
Cholangiocyte biology in primary sclerosing cholangitis and other cholangiopathies: pathogenesis, clinical insights, and experimental tools	45
Protease-activated receptors in health and disease	45

Publisher’s note	41
The neurobiology of parenting and infant-evoked aggression	41
Human temperature regulation under heat stress in health, disease, and injury	41
Multiscale structure and function of the aortic valve apparatus	40
Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis	39
Sympathetic circuits regulating hepatic glucose metabolism: where we stand	39
Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches	39
Vascular mechanotransduction	38
Hepatic glucagon action: beyond glucose mobilization	38
Uterine fibroids	36
Cysteine-based redox sensors in the cardiovascular system: from identification to physiology and drug discovery	36
Extracellular vesicles and the lung: from disease pathogenesis to biomarkers and treatments	35
Deconstructing the GWAS library: next-generation GWAS	35
Physiological basis for xenotransplantation from genetically modified pigs to humans	34
Examining the shared etiology of psychopathology with genome-wide association studies	34
The multiple roles of salt-inducible kinases in regulating physiology	34
Lymphatic vessels in cancer	33
Windows into stress: a glimpse at emerging roles for CRH^PVN neurons	33
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training	32
Acid-sensing ion channels: structure, function, pharmacology, and clinical significance	31
Corrigendum for Eisner et al., volume 103, 2023, p. 2767–2845	31
Psychophysiological foundations of human physical activity behavior and motivation: theories, systems, mechanisms, evolution, and genetics	31