Science

Article	Citations
Accurate prediction of protein structures and interactions using a three-track neural network	2878
Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)	2549
The GTEx Consortium atlas of genetic regulatory effects across human tissues	2399
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients	2217
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection	2091
The effect of human mobility and control measures on the COVID-19 epidemic in China	2026
Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England	1923
Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing	1879
Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period	1879
Autoantibodies against type I IFNs in patients with life-threatening COVID-19	1840
Copper induces cell death by targeting lipoylated TCA cycle proteins	1617
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19	1577
Cytokine release syndrome in severe COVID-19	1463
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2	1436
An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China	1432
Predicted growth in plastic waste exceeds efforts to mitigate plastic pollution	1394
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity	1390
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV	1310
The world of two-dimensional carbides and nitrides (MXenes)	1282
Quantum computational advantage using photons	1261
SARS-CoV-2 productively infects human gut enterocytes	1256
The complete sequence of a human genome	1251
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model	1218
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2	1217
Site-specific glycan analysis of the SARS-CoV-2 spike	1202

Structure of the RNA-dependent RNA polymerase from COVID-19 virus	1173
Monolithic perovskite/silicon tandem solar cell with >29% efficiency by enhanced hole extraction	1162
Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies	1155
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications	1152
Stable perovskite solar cells with efficiency exceeding 24.8% and 0.3-V voltage loss	1141
Development of an inactivated vaccine candidate for SARS-CoV-2	1118
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease	1094
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail	1089
The human tumor microbiome is composed of tumor type–specific intracellular bacteria	1081
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19	1079
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability	1051
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil	1024
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans	988
Robust neutralizing antibodies to SARS-CoV-2 infection persist for months	978
Distinct conformational states of SARS-CoV-2 spike protein	964
Impact of strain relaxation on performance of α-formamidinium lead iodide perovskite solar cells	956
Neuropilin-1 is a host factor for SARS-CoV-2 infection	956
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes	947
The global threat from plastic pollution	933
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2	925
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans	923
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis	921
DNA vaccine protection against SARS-CoV-2 in rhesus macaques	915
Conformal quantum dot–SnO 2 layers as electron transporters for efficient perovskite solar cells	912
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir	909
Covalent surface modifications and superconductivity of two-dimensional metal carbide MXenes	894
Anomalous absorption of electromagnetic waves by 2D transition metal carbonitride Ti 3 CNT x (M	878
Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China	857
Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans	837
An astronomically dated record of Earth’s climate and its predictability over the last 66 million years	814
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients	786
Estimating the burden of SARS-CoV-2 in France	782
Evaluating scenarios toward zero plastic pollution	776
Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients	761
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo	754
Global threat of arsenic in groundwater	750
SARS-CoV-2 infection protects against rechallenge in rhesus macaques	738
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model	736
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells	729
Evolutionary-scale prediction of atomic-level protein structure with a language model	726
Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial	717
Airborne transmission of respiratory viruses	702
COVID-19 risks to global food security	691
Inactive (PbI 2 ) 2 RbCl stabilizes perovskite films for efficient solar cells	688
Inferring the effectiveness of government interventions against COVID-19	682
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans	678
Rational design of layered oxide materials for sodium-ion batteries	658
Prospective mapping of viral mutations that escape antibodies used to treat COVID-19	657
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy	651
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy	648

Semiconductor quantum dots: Technological progress and future challenges	634
Material-structure-performance integrated laser-metal additive manufacturing	630
The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries	627
Reducing transmission of SARS-CoV-2	626
Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China	625
Plastic rain in protected areas of the United States	614
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2	611
Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions	601
Exceeding 1.5°C global warming could trigger multiple climate tipping points	595
Pervasive shifts in forest dynamics in a changing world	592
Rapid COVID-19 vaccine development	592
Chemical vapor deposition of layered two-dimensional MoSi 2 N 4 materials	585
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern	585
A rechargeable zinc-air battery based on zinc peroxide chemistry	584
High-entropy-stabilized chalcogenides with high thermoelectric performance	583
Microplastics and human health	574
Microplastic in terrestrial ecosystems	571
CO 2 electrolysis to multicarbon products in strong acid	569
Organometallic-functionalized interfaces for highly efficient inverted perovskite solar cells	559
Antimicrobial peptides: Application informed by evolution	558
Unexpected air pollution with marked emission reductions during the COVID-19 outbreak in China	556
Model-informed COVID-19 vaccine prioritization strategies by age and serostatus	548
Vapor-assisted deposition of highly efficient, stable black-phase FAPbI 3 perovskite solar cells	545
Recent advances in solid oxide cell technology for electrolysis	534
A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon	534
Structural basis of a shared antibody response to SARS-CoV-2	527
Broad neutralization of SARS-related viruses by human monoclonal antibodies	523
ChatGPT is fun, but not an author	523
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges	521
Stabilizing black-phase formamidinium perovskite formation at room temperature and high humidity	520
Global food system emissions could preclude achieving the 1.5° and 2°C climate change targets	513
The microbiome and human cancer	512
A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2	510
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2	503
Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa	500
Reversible planar gliding and microcracking in a single-crystalline Ni-rich cathode	489
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms	488
Constructing heterojunctions by surface sulfidation for efficient inverted perovskite solar cells	484
Pan-cancer single-cell landscape of tumor-infiltrating T cells	482
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms	479
A piperidinium salt stabilizes efficient metal-halide perovskite solar cells	477
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity	476
CAR T cells produced in vivo to treat cardiac injury	468
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings	466
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex	466
Hartree-Fock on a superconducting qubit quantum computer	465
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors	460
The immunology and immunopathology of COVID-19	452
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters	450
Glymphatic failure as a final common pathway to dementia	443
Fracture, fatigue, and friction of polymers in which entanglements greatly outnumber cross-links	442
A human cell atlas of fetal gene expression	440
Per- and polyfluoroalkyl substances in the environment	438
Hierarchical-morphology metafabric for scalable passive daytime radiative cooling	435
Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape	434
Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants	434
Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine–elicited human sera	432
Evolution and epidemic spread of SARS-CoV-2 in Brazil	428
Stabilizing perovskite-substrate interfaces for high-performance perovskite modules	428
Seafloor microplastic hotspots controlled by deep-sea circulation	427
Carbon-free high-loading silicon anodes enabled by sulfide solid electrolytes	420
Poverty, depression, and anxiety: Causal evidence and mechanisms	408
Polyethylene upcycling to long-chain alkylaromatics by tandem hydrogenolysis/aromatization	404
Biphenylene network: A nonbenzenoid carbon allotrope	403
Self-assembled monolayers direct a LiF-rich interphase toward long-life lithium metal batteries	402
Terrestrial radiative cooling: Using the cold universe as a renewable and sustainable energy source	401
mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection	400
Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat	396
A strategic approach to COVID-19 vaccine R&D	395
Forest microclimate dynamics drive plant responses to warming	394
Damp heat–stable perovskite solar cells with tailored-dimensionality 2D/3D heterojunctions	391
Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques	388
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement	386
Giant thermopower of ionic gelatin near room temperature	386
Thermal bottlenecks in the life cycle define climate vulnerability of fish	383
Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic	381
The soundscape of the Anthropocene ocean	379
Estimating infectiousness throughout SARS-CoV-2 infection course	374
Nanomesh pressure sensor for monitoring finger manipulation without sensory interference	374
Scalable thermochromic smart windows with passive radiative cooling regulation	371

A general method to synthesize and sinter bulk ceramics in seconds	371
Sulfur-anchoring synthesis of platinum intermetallic nanoparticle catalysts for fuel cells	370
Physical traits of cancer	370
Robust deep learning–based protein sequence design using ProteinMPNN	369
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response	367
Social determinants of health and survival in humans and other animals	367
Lead halide–templated crystallization of methylamine-free perovskite for efficient photovoltaic modules	366
Stacking-engineered ferroelectricity in bilayer boron nitride	362
A molecular pore spans the double membrane of the coronavirus replication organelle	361
Tough hydrogels with rapid self-reinforcement	360
Artificial multimodal receptors based on ion relaxation dynamics	359
Climate-driven risks to the climate mitigation potential of forests	356
Chiral-induced spin selectivity enables a room-temperature spin light-emitting diode	354
Haplotype-resolved diverse human genomes and integrated analysis of structural variation	353
Black phosphorus composites with engineered interfaces for high-rate high-capacity lithium storage	353
Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention	351
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody	346
Ecology and economics for pandemic prevention	344
Epidemiology and transmission dynamics of COVID-19 in two Indian states	343
CRISPR-CasΦ from huge phages is a hypercompact genome editor	343
Succination inactivates gasdermin D and blocks pyroptosis	341
Miniaturization of optical spectrometers	341
Structural impact on SARS-CoV-2 spike protein by D614G substitution	334
Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein	334
SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern	331
Recent global decline of CO 2 fertilization effects on vegetation photosynthesis	330
Realization of a multinode quantum network of remote solid-state qubits	330
Gradient cell–structured high-entropy alloy with exceptional strength and ductility	329
Critical instability at moving keyhole tip generates porosity in laser melting	329
Interfacial toughening with self-assembled monolayers enhances perovskite solar cell reliability	328
Enhanced atomic ordering leads to high thermoelectric performance in AgSbTe 2	327
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike	326
Introductions and early spread of SARS-CoV-2 in the New York City area	326
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection	325
The impact of sex on gene expression across human tissues	325
Tertiary lymphoid structures in cancer	324
A scalable metal-organic framework as a durable physisorbent for carbon dioxide capture	322
SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model	321
A massive rock and ice avalanche caused the 2021 disaster at Chamoli, Indian Himalaya	320
Computed structures of core eukaryotic protein complexes	316
Hierarchical crack buffering triples ductility in eutectic herringbone high-entropy alloys	316
Political sectarianism in America	315
Aligned, high-density semiconducting carbon nanotube arrays for high-performance electronics	315
Early detection of cancer	315
Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK	314
Using nature’s blueprint to expand catalysis with Earth-abundant metals	313
High-strength scalable MXene films through bridging-induced densification	313
Probing topological spin liquids on a programmable quantum simulator	313
COVID-19 and cancer	311
The emergence of SARS-CoV-2 in Europe and North America	310
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling	309
Nitrogen reduction to ammonia at high efficiency and rates based on a phosphonium proton shuttle	308
Diverse enzymatic activities mediate antiviral immunity in prokaryotes	308
Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice	307
The nucleus acts as a ruler tailoring cell responses to spatial constraints	307
Plastics in the Earth system	306
Gas chromatography–mass spectrometry analyses of encapsulated stable perovskite solar cells	306
High-precision measurement of the W boson mass with the CDF II detector	304
Immunological characteristics govern the transition of COVID-19 to endemicity	304
Toward polymer upcycling—adding value and tackling circularity	301
The ecological and evolutionary consequences of systemic racism in urban environments	299
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly	298
Rapid implementation of mobile technology for real-time epidemiology of COVID-19	297
Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ	297
Evolution of water structures in metal-organic frameworks for improved atmospheric water harvesting	296
Optical frequency combs: Coherently uniting the electromagnetic spectrum	296
Ultrahigh energy storage in superparaelectric relaxor ferroelectrics	295
Controlling interdependent meso-nanosecond dynamics and defect generation in metal 3D printing	295
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape	294
Type III interferons disrupt the lung epithelial barrier upon viral recognition	294
Thermosensitive crystallization–boosted liquid thermocells for low-grade heat harvesting	293
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2	293
An orally available non-nucleotide STING agonist with antitumor activity	291
Manipulating matter by strong coupling to vacuum fields	291
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants	291
Power generation and thermoelectric cooling enabled by momentum and energy multiband alignments	291
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence	290
Serology assays to manage COVID-19	290
Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2	289
Cross-tissue immune cell analysis reveals tissue-specific features in humans	288
Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme	288
Cell-free chemoenzymatic starch synthesis from carbon dioxide	286
Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera	285
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma	285
Serial interval of SARS-CoV-2 was shortened over time by nonpharmaceutical interventions	284
Partitioning of cancer therapeutics in nuclear condensates	283
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans	283
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity	283
Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate	282
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer	282
De novo assembly, annotation, and comparative analysis of 26 diverse maize genomes	281
Interfacial ferroelectricity by van der Waals sliding	279
Assessing China’s efforts to pursue the 1.5°C warming limit	279
Comprehensive quantification of fuel use by the failing and nonfailing human heart	278
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody	278