OOIR: Observatory of International Research

Papers

(The TQCC of Steroids is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Editorial Board	51
Synthesis of methotrexate-betulonic acid hybrids and evaluation of their effect on artificial and Caco-2 cell membranes	32
Acute serum protein and cytokine response of single dose of prednisone in adult volunteers	29
Effects of estradiol, progesterone or cAMP on expression of PGRMC1 and progesterone receptor in a xenograft model of human endometrium and in endometrial cell culture	27
Mitochondrial dysfunction and cardiac ischemia/reperfusion injury are attenuated by nandrolone: Role of JAK-STAT3 pathway	27
Retraction notice to “Thyroid hormone is a MAPK-dependent growth factor for thyroid cancer cells and is anti-apoptotic” [Steroids 72(2) 2007 180–187]	25
Cortisol resistance in the degu (Octodon degus)	24
Roles of equol and the PI3K/Akt signaling pathway in the cardioprotective effects of enteral daidzein against ischemia–reperfusion injury in isolated rat hearts	22
Functions of dehydroepiandrosterone in relation to breast cancer	22
Ursane hybrids with 5-amino-1,2,3,4-thiatriazole, 1-tetrazole-5-thione, and 1-tetrazole-5-amines and study of their inhibition of main SARS-CoV-2 protease	21
The roles of methylprednisolone treatment in patients with COVID-19: A systematic review and meta-analysis	20
Acquired 11β-Hydroxylase deficiency in etomidate and (Iso)propoxate abusers: A nascent endocrine condition	20
Mineralocorticoid receptor antagonism of vamorolone: Evidence from LIONHEART and VISION-DMD clinical trials	19
Membrane progesterone receptors on the cell membrane: A review highlighting potential export motifs in mPRα regulating its trafficking to the cell surface	19
Isolation, structural elucidation of new phytoecdysteroids from Ajuga decumbens Thunb	19
Ligand-based analysis of the antifungal potential of phytosterols and triterpenes isolated from Cryptostegia grandiflora against Candida auris FKBP12	18
Nandrolone decanoate induced kidney injury through miRNA-146a targeting IRAK1 and TRAF6 via activation of the NF-κB pathway: The effect of moderate exercise	18
Biotransformation of hydrocortisone succinate with whole cell cultures of Monascus purpureus and Cunninghamella echinulata	17
The location of estrogen receptor variant ER-α36 is associated with the invasion of glioblastoma	16
Unleashing the pharmacological potential of taste receptors in reproductive processes beyond their gustatory role	16
Antitumor potential of novel 5α,6β-dibromo steroidal D-homo lactone	16
An improved synthesis of azedarachol	16
Editorial Board	16
Synthesis, antifungal evaluation, and molecular docking studies of steroidal thiazolopyrimidines	15
Ascorbic acid Mitigates behavioural disturbances associated with letrozole-induced PCOS via switching-off JAK2/STAT5 and JAK2/ERK1/2 pathways in rat hippocampus	15

Drugs possessing aryloxypropanamine pharmacophore, duloxetine, dapoxetine and propranolol, increase allopregnanolone in rat brain: Possible involvement of allopregnanolone in their central nervous sys	15
Exploring the urate lowering properties of Erigeron annuus Lin. and phytosterol contributions: In vitro assays and in silico approaches	15
Insight into isolation and elucidation of cytotoxic ergostanoids from the mushroom Sarcosphaera crassa (Santi) Pouzar: An edible mushroom	14
Epoxide of diosgenin acetate synthesis: DoE for diastereoselective yield optimization, antimicroibial, antioxidant and antiproliferative effects	14
Target-specific high-throughput screening of anti-inflammatory phytosteroids for autoimmune diseases: A molecular docking-dynamics simulation approach	14
Synthesis and antitumor activity of some cholesterol-based selenocyanate compounds	13
17beta-estradiol alleviates contusion-induced skeletal muscle injury by decreasing oxidative stress via SIRT1/PGC-1α/Nrf2 pathway	13
Androgenic steroids in Over-the-Counter dietary Supplements: Analysis for association with adverse health effects	13
Characterization and functional analysis of BmSR-B1 for phytosterol uptake	12
TFA-mediated stereoselective aza-Michael addition for the synthesis of 3β-arylamine derivatives of withaferin A and evaluation of their anticancer potential	12
Synthesis, anti-leukemia activity, and molecular docking of novel 3,16-androstenedione derivatives	12
Retraction notice to “Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2“ [STE 202 (2024) 109351]	12
Polycystic ovary syndrome: Insights into its prevalence, diagnosis, and management with special reference to gut microbial dysbiosis	12
The effect of transdermal 17β-estradiol combined with norethisterone acetate treatment on the lipid profile in postmenopausal women: A meta-analysis and systematic review of randomized controlled tria	11
Editorial Board	11
Theoretical study of the pyridyl-cholestane formation pathway using DFT: A stepwise mechanistic approach	11
Response to ‘25-OH Vitamin D concentrations measured by LC-MS/MS are equivalent in serum and EDTA plasma’	11
Antibacterial activity of withanolides and their structure-activity relationship	10
A novel role of catalase in cholesterol uptake of Helicobacter pylori	10
Investigating the influence of estrous cycle-dependent hormonal changes on neurogenesis in adult mice	10
Systemic corticosteroid use and cardiovascular risk in patients hospitalized for pneumonia	10
Synthesis and cytotoxicity of betulin and betulinic acid derived 30-oxo-amides	10
Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo	10
Synthesis and biological evaluation of novel steroidal pyrazole amides as highly potent anticancer agents	10
Filamin A in triple negative breast cancer	10
European Network for oxysterol research (ENOR): 10th ENOR symposium – Web meeting	9
Endocannabinoid and steroid hormone levels during and after pregnancy in fingernail samples from mothers and their infants	9
Editorial Board	9
The effect of various corticosteroids in the hospitalized patients with moderate and severe COVID-19: A tertiary hospital experience	9
The role of estrogen metabolites in human ovarian function	9
Synthesis of hyocholic acid and its derivatization with sodium periodate to distinguish it from cholic acid by mass spectrometry	9
Genetic insights into vitamin D deficiency: a case-control study of GC and CYP24A1 gene polymorphism	9
Progestogens exhibit progestogen-, promoter- and isoform-specific effects via the progesterone receptor	9
Editorial Board	8
Vitamin D potentiation of metformin hepatoprotective activities: Concurrent targeting of carbohydrate enzymatic pathways and PCSK9/AGEs-regulated oxidative stress mechanisms in type 2 diabetic male Wi	8
Isosteroidal alkaloids from Fritillaria hupehensis Hsiao et K.C.Hsia: Synthesis and biological evaluation of alkaloid derivatives as potential cytotoxic agents	8
Shatavarin-IV, a steroidal saponin from Asparagus racemosus, inhibits cell cycle progression and epithelial-to-mesenchymal transition in AGS cells under hyperglycemic conditions	8
Synthesis and characterization of epoxide impurities of abiraterone acetate	8
20-Hydroxyecdysone bioavailability and pharmacokinetics in Gerbillus tarabuli, a gerbil model for metabolic syndrome studies	8
A hormonal side effect of anabolic steroids among a sample of Baghdad male bodybuilders	8
Estrogen signaling in healthy and tumor brain	8
New secondary metabolites from the soil-derived Aspergillus versicolor QC812	7
Corrigendum to “Effects of neural-derived estradiol on actin polymerization and synaptic plasticity-related proteins in prefrontal and hippocampal cells of mice” [Steroids 177 (2022) 108935]	7
Dehydroepiandrosterone supplementation improves diminished ovarian reserve clinical and in silico studies	7
Evaluation of structural and thermodynamic insight of ERβ with DPN and derivatives through MMGBSA/MMPBSA methods	7
Mifepristone’s effects on depression- and anxiety-like behavior in rodents	7
Synthesis and anti-inflammatory effects of Δ7-Cholestenol and Δ8(14)-Cholestenol derivatives	7
Triazole-estradiol analogs: A potential cancer therapeutic targeting ovarian and colorectal cancer	7
Corrigendum to “Advances in the understanding of androgen receptor structure and function and in the development of next-generation AR-targeted therapeutics”. [Steroids 210 (2024) 109486]	7
Testosterone replacement has a beneficial effect on the hemostatic system by altered gene expression of coagulation factors	7

Editorial Board	7
An overview on androgen-mediated actions in skeletal muscle and adipose tissue	7
Anti-cancer activity, and molecular docking of novel hybrid heterocyclic steroids revealed promising anti-hepatocellular carcinoma agent: Implication of cyclin dependent kinase-2 pathway	7
Kuwanon C inhibits proliferation and induction of apoptosis via the intrinsic pathway in MDA-MB231 and T47D breast cancer cells	7
Synthesis, NMR and X-ray characterization of dibenzoannulated dimeric steroid spiroketals. Evaluation of cytotoxicity and anti-inflammatory activity	7
Navigating nonalcoholic fatty liver disease (NAFLD): Exploring the roles of estrogens, pharmacological and medical interventions, and life style	7
Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review	7
An association of VDR gene polymorphism in hypovitaminosis D mediated secondary hyperparathyroidism in adolescent girls; a tertiary hospital study in central India	7
BSS-4, a diosgenin analogue, reduces carrageenan-induced paw inflammation in rat	6
Mass spectrometric stochastic dynamic 3D structural analysis of mixture of steroids in solution – Experimental and theoretical study	6
Expression of pregnenolone-synthesizing enzymes CYP11A1 and CYP1B1 in the human, rat, and mouse brain	6
Application of a fluorine strategy in the lead optimization of betulinic acid to the discovery of potent CD73 inhibitors	6
Editorial Board	6
Rfamide-related peptide-3(RFRP-3) receptor gene is expressed in mouse ovarian granulosa cells: Potential role of RFRP-3 in steroidogenesis and apoptosis	6
An efficient regioconvergent synthesis of 3-aza-obeticholic acid	6
A comprehensive update on phytochemistry, analytical aspects, medicinal attributes, specifications and stability of stigmasterol	6
Steroids from the mushroom Ganoderma shandongense and their AChE inhibitory activities	6
Anti-apoptotic effects of diosgenin on ovariectomized hearts	6
Vecuronium bromide and its advanced intermediates: A crystallographic and spectroscopic study	6
Validation of a LC-MS/MS method for establishing reference intervals and assessing diagnostic performance of urinary free cortisol and cortisone	6
Metabolism of progestogens used for contraception and menopausal hormone therapy	5
Navigating a plethora of progesterone receptors: Comments on the safety/risk of progesterone supplementation in women with a history of breast cancer or at high-risk for developing breast cancer	5
Natural products derived steroids as potential anti-leishmanial agents; disease prevalence, underlying mechanisms and future perspectives	5
The interpretation of immunometric, chromatographic and mass spectrometric data for steroids in diagnosis of endocrine disorders	5
Descriptive analysis of the relationship between progesterone and basal body temperature across the menstrual cycle	5
Reaction of 7α-bromo-6-nitrocholest-5-enes with hydrazine: Formation of steroidal pyrazolines and molecular docking against SARS-CoV-2 omicron protease	5
Editorial Board	5
Microwave-assisted one-pot multicomponent synthesis of steroidal pyrido[2,3-d]pyrimidines and their possible implications in drug development	5
The effect of vitamin D2 supplementation on vitamin D levels in humans: A time and dose–response meta-analysis of randomized controlled trials	5
Effect of betulinic acid on MepA efflux pump inhibition in Staphylococcus aureus: Antibacterial and molecular study	5
Practical synthesis of chenodeoxycholic acid from phocaecholic acid	5
Dexamethasone induces cancer mitigation and irreversible senescence in lung cancer cells via damaging cortical actin and sustained hyperphosphorylation of pRb	5
Editorial Board	5
Synthesis of fully functionalized spirostanic 1,2,3-triazoles by the three component reaction of diosgenin azides with acetophenones and aryl aldehydes and their biological evaluation as antiprolifera	5
Sonogashira coupling-based synthesis and in vitro cytotoxic evaluation of C-2 alkynyl derivatives of withaferin A	5
Structures and functions of human placental aromatase and steroid sulfatase, two key enzymes in estrogen biosynthesis	5
Significance of vitamin D responsiveness on the etiology of vitamin D-related diseases	5
Editorial Board	5
Microbial catalyzed derivatization of canrenone with Glomerella fusarioides, and Cunninghamella blakesleana, and evaluation of aromatase inhibitory activity of the resulting metabolites	5
A simple and efficient approach for the synthesis of cholesterol esters of long-chain saturated fatty acids by using Ph3P·SO3 as a versatile organocatalyst	4
Effects of hypothyroidism on the female pancreas involve the regulation of estrogen receptors	4
Sudanese Toombak smokeless tobacco users harbour significantly altered long–term cortisol body production	4
The advancement of structure, bioactivity, mechanism, and synthesis of bufotalin	4
Intramuscular sex steroid hormones are reduced after resistance training in postmenopausal women, but not affected by estrogen therapy	4
Editorial Board	4
Advances in the understanding of androgen receptor structure and function and in the development of next-generation AR-targeted therapeutics	4
Comparison of a chemiluminescence immunoassay with LC–MS/MS in the determination of the plasma aldosterone concentration in patients with impaired renal function	4
25-OH Vitamin D concentrations measured by LC-MS/MS are equivalent in serum and EDTA plasma	4
Structural and functional characterization of genes and enzymes involved in withanolide biosynthesis in Physalis alkekengi L.	4
The isomers, aloe-emodin and emodin, possess differential inhibitory activities against CYP1B1 enzyme	4
Therapeutic effects of Stemmoside C against Salmonella enterica serotype typhimurium infected BALB/c mice	4
Parisvaniosides A–E, five new steroidal saponins from Paris vaniotii	4
The Effect of Vitamin D3 supplementation on Flunitrazepam-Induced testicular dysfunction in Wistar rats	4
Design, synthesis and characterization of novel cholesterol derivatives: Anti-cancer activity, ADMET profiling and DFT insights	4
Synthesis and anticancer properties of a hybrid molecule with the testosterone and estradiol head-groups	4
Current advances in phytosterol free forms and esters: Classification, biosynthesis, chemistry, and detection	4
Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated	4
Endocrine disruptors and arterial hypertension: A developing story	4
Understanding the role of hormones in pediatric growth: Insights from a double-debiased machine learning approach	4
Sinulasterols D–G, four new antibacterial steroids from the South China sea soft coral Sinularia depressa	4
Rodent models in polycystic ovarian syndrome: Dissecting reproductive and metabolic phenotypes for therapeutic advancements	4
MiR-221-5p/Smad3 axis in osteoclastogenesis and its function: Potential therapeutic target for osteoporosis	4
Editorial Board	4
Corticosteroids: A boon or bane for COVID-19 patients?	4
Tricholosterols A–D, four new ergosterol derivatives from the mushroom Tricholoma terreum	4
Bone mineral density, trabecular bone score and muscle strength in transgender men receiving testosterone therapy versus cisgender men	4