OOIR: Observatory of International Research

Papers

(The TQCC of Steroids is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase	77
The steroidal alkaloids α-tomatine and tomatidine: Panorama of their mode of action and pharmacological properties	32
An overview of the classical and tissue-derived renin-angiotensin-aldosterone system and its genetic polymorphisms in essential hypertension	30
Updates in bile acid-bioactive molecule conjugates and their applications	27
Cucurbitacin IIb, a steroidal triterpene from Ibervillea sonorae induces antiproliferative and apoptotic effects on cervical and lung cancer cells	26
Steroidal saponins and sapogenins from fenugreek and their inhibitory activity against α-glucosidase	26
Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic andro	25
Regulation of cholesterol biosynthesis and lipid metabolism: A microRNA management perspective	21
Vitamin D receptor genetic polymorphisms and the risk of multiple sclerosis: A systematic review and meta-analysis	21
A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma	21
Russelioside B; A pregnane glycoside for treatment of gastric ulcer via modulation of heat shock protein-70 and vascular endothelial growth factor	20
Quantification of endogenous steroid sulfates and glucuronides in human urine after intramuscular administration of testosterone esters	19
The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome	19
Hair cortisol measurement in older adults: Influence of demographic and physiological factors and correlation with perceived stress	19
Deoxycholic acid as a molecular scaffold for tyrosyl-DNA phosphodiesterase 1 inhibition: A synthesis, structure–activity relationship and molecular modeling study	19
An insight on 7- ketocholesterol mediated inflammation in atherosclerosis and potential therapeutics	18
An in vitro investigation of endocrine disrupting potentials of ten bisphenol analogues	17
Hepcidin, an overview of biochemical and clinical properties	17
Inhibition of EZH2 via the STAT3/HOTAIR signalling axis contributes to cell cycle arrest and apoptosis induced by polyphyllin I in human non-small cell lung cancer cells	16
Effects of Cangfu Daotan Decoction on obese polycystic ovary syndrome and its mechanism	16
Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta	16
Metabolomic profiling of five Agave leaf taxa via UHPLC/PDA/ESI-MS inrelation to their anti-inflammatory, immunomodulatory and ulceroprotective activities	16
Synthesis and cytotoxicity of hybrids of 1,3,4- or 1,2,5-oxadiazoles tethered from ursane and lupane core with 1,2,3-triazole	16
Synthesis of steroidal dihydropyrazole derivatives using green ZnO NPs and evaluation of their anticancer and antioxidant activity	15
Azasteroids from diosgenin: Synthesis and evaluation of their antiproliferative activity	15

A review on synthesis and biological activities of D-ring modified pregnenolone	15
Synthesis, antimicrobial potency with in silico study of Boc-leucine-1,2,3-triazoles	15
Enterohepatic circulation of bile acids and their emerging roles on glucolipid metabolism	15
Dutasteride combined with androgen receptor antagonists inhibit glioblastoma U87 cell metabolism, proliferation, and invasion capacity: Androgen regulation	15
Anticancer potential of cardiac glycosides and steroid-azole hybrids	14
New 20(S)-protopanaxadiol type saponins from the leaves of Panax notoginseng and their potential anti-inflammatory activities	14
Anabolic steroid excess and myocardial infarction: From ischemia to reperfusion injury	14
Anticancer properties of caudatin and related C-21 steroidal glycosides from Cynanchum plants	14
A spirostanol saponin isolated from Tupistra chinensis Baker simultaneously induces apoptosis and autophagy by regulating the JNK pathway in human gastric cancer cells	14
Investigation of the possible mechanism of two kinds of sterols extracted from Leucocalocybe mongolica in inducing HepG2 cell apoptosis and exerting anti-tumor effects in H22 tumor-bearing mice	14
Organotin derivatives of cholic acid induce apoptosis into breast cancer cells and interfere with mitochondrion; Synthesis, characterization and biological evaluation	14
Survey of protein-based sport supplements for illegally added anabolic steroids methyltestosterone and 4-androstenedione by UPLC-MS/MS	13
SAR based in-vitro anticholinesterase and molecular docking studies of nitrogenous progesterone derivatives	13
Anti-atherogenic effect of Nepitrin-7-O-glucoside: A flavonoid isolated from Nepeta hindostana via acting on PPAR – α receptor	13
Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to ag	13
The roles of methylprednisolone treatment in patients with COVID-19: A systematic review and meta-analysis	13
Synthesis, pharmacological evaluation and Molecular modelling studies of pregnenolone derivatives as inhibitors of human dihydrofolate reductase	13
Recent advances in the bile acid based conjugates/derivatives towards their gelation applications	13
A review on steroid dimers: 2011–2019	12
Differential off-target glucocorticoid activity of progestins used in endocrine therapy	12
Fabrication of deoxycholic acid tethered α-cyanostilbenes as smart low molecular weight gelators and AIEE probes for bio-imaging	12
Synthesis and antiproliferative evaluation of some novel estradiol selenocyanates	12
Increased cholesterol absorption is associated with In-stent-restenosis after stent implantation for stable coronary artery disease	12
The effects of dehydroepiandrosterone (DHEA) supplementation on body composition and blood pressure: A meta-analysis of randomized clinical trials	11
Synthesis and biological evaluation of novel steroidal pyrazole amides as highly potent anticancer agents	11
Linoleic acid promotes testosterone production by activating Leydig cell GPR120/ ERK pathway and restores BPA-impaired testicular toxicity	11
Measurement of steroid hormones by liquid chromatography-tandem mass spectrometry with small amounts of hair	11
Association of exposure to prenatal phthalate esters and bisphenol A and polymorphisms in the ESR1 gene with the second to fourth digit ratio in school-aged children: Data from the Hokkaido study	11
New A-homo lactam D-homo lactone androstane derivative: Synthesis and evaluation of cytotoxic and anti-inflammatory activities in vitro	11
Synthesis and anti-inflammatory activity of novel steroidal chalcones with 3β-pregnenolone ester derivatives in RAW 264.7 cells in vitro	11
Synthesis of diosgenyl quaternary ammonium derivatives and their antitumor activity	11
Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated	11
The presence of a cationic center is not alone decisive for the cytotoxicity of triterpene carboxylic acid amides	11
Stochastic dynamic mass spectrometric quantification of steroids in mixture — Part II	11
Bioactive stigmastadienone from Isodon rugosus as potential anticholinesterase, α-glucosidase and COX/LOX inhibitor: In-vitro and molecular docking studies	10
Type and position of linkage govern the cytotoxicity of oleanolic acid rhodamine B hybrids	10
Corticosteroids: A boon or bane for COVID-19 patients?	10
Involvement of kynurenine pathway in depressive-like behaviour induced by nandrolone decanoate in mice	10
Synthesis of erythrodiol C-ring derivatives and their activity against Chlamydia trachomatis	10
Effects of synthetic glucocorticoids on breast cancer progression	10
Steroidal saponins from Raphia vinifera and their cytotoxic activity	10
Sinulasterols A–C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa	10
Bile acid-based receptors and their applications in recognition	10
Bone mineral density, trabecular bone score and muscle strength in transgender men receiving testosterone therapy versus cisgender men	10
Cytotoxic ergostane-type steroids from Ganoderma lingzhi	10
Screening and identification of salivary biomarkers for assessing the effects of exogenous testosterone administration on HPG and HPA axes and ECS	9
Polyhydroxylated steroids from the Vietnamese soft coral Sarcophyton ehrenbergi	9
Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20-methylpregn-4-en-3-one	9
Research progress in the application of bile acid-drug conjugates: A “trojan horse” strategy	9
Genomic signaling of vitamin D	9

Novel combination of multi-walled carbon nanotubes and gold nanocomposite for photothermal therapy in human breast cancer model	9
Production aspects of testosterone by microbial biotransformation and future prospects	9
Recent advances in chemical synthesis, biocatalysis, and biological evaluation of diosgenin derivatives – A review	9
Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation	8
The effect of dehydroepiandrosterone (DHEA) supplementation on estradiol levels in women: A dose-response and meta-analysis of randomized clinical trials	8
Pd-catalyzed Suzuki–Miyaura couplings and evaluation of 13α-estrone derivatives as potential anticancer agents	8
Formation of nitrogen-containing six-membered heterocycles on steroidal ring system: A review	8
Changes in conjugated urinary bile acids across age groups	8
Testicular induced corticosterone synthesis in male rats under fasting stress	7
Synthesis and biological evaluation of 17-cyanopyridine derivatives of pregnenolone as potential anti-prostate cancer agents	7
Bioassay-guided isolation and identification of anti-ulcer ecdysteroids from the seeds of Sphenocentrum jollyanum Pierre (Menispermaceae)	7
Progesterone decreases ovarian cancer cells migration and invasion	7
MicroRNA-23b-3p participates in steroid-induced osteonecrosis of the femoral head by suppressing ZNF667 expression	7
Mass spectrometric stochastic dynamic 3D structural analysis of mixture of steroids in solution – Experimental and theoretical study	7
Detection and quantitation of ecdysterone in human serum by liquid chromatography coupled to tandem mass spectrometry	7
Analysis of steryl glucosides in rice bran-based fermented food by LC/ESI-MS/MS	7
Triazole-estradiol analogs: A potential cancer therapeutic targeting ovarian and colorectal cancer	7
Impaired attention in patients with adrenal insufficiency – Impact of unphysiological therapy	7
Synthesis, antifungal evaluation, and molecular docking studies of steroidal thiazolopyrimidines	7
Prolonged bisphenol-A exposure decreases endocrine pancreatic proliferation in response to obesogenic diet in ovariectomized mice	7
Effects of exercise training on glucocorticoid-induced muscle atrophy: Literature review	7
Cucurbitacin E shows synergistic effect with sorafenib by inducing apoptosis in hepatocellular carcinoma cells and regulates Jak/Stat3, ERK/MAPK, PI3K/Akt/mTOR signaling pathways	7
Novel mutations of the CYP17A1 gene in four Chinese 46,XX cases with partial 17a-hydroxylase/17,20-lyase deficiency	7
Potential role of mycosterols in hyperlipidemia – A review	7
Development of a LC-MS/MS method to measure serum 3-sulfate and 3-glucuronide 25-hydroxyvitamin D3 metabolites; comparisons to unconjugated 25OHD in pregnancy and polycystic ovary syndrome	7
Arthriniumsteroids A–D, four new steroids from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212	6
Influence of synthetic isoflavones on selected urinary steroid biomarkers: Relevance to doping control	6
DG-8d, a novel diosgenin derivative, decreases the proliferation and induces the apoptosis of A549 cells by inhibiting the PI3k/Akt signaling pathway	6
Circulating steroids and mood disorders in patients with polycystic ovary syndrome	6
Molecular docking simulation and in vitro studies on estrogenic activities of flavonoids from leaves of Carya cathayensis Sarg	6
Phytochemical Investigation, In silico/In vivo Analgesic, and Anti-inflammatory Assessment of the Egyptian Cassia occidentalis L.	6
Biological activity and apoptotic signaling pathway of C11-functionalized cephalostatin 1 analogues	6
A pseudo-targeted metabolomics study based on serum bile acids profiling for the differential diagnosis of benign and malignant breast lesions	6
Synthesis of human long-term metabolites of dehydrochloromethyltestosterone and oxymesterone	6
Phoenix dactylifera L. date tree pollen fertility effects on female rats in relation to its UPLC-MS profile via a biochemometric approach	6
Microwave-assisted one-pot multicomponent synthesis of steroidal pyrido[2,3-d]pyrimidines and their possible implications in drug development	6
A comprehensive update on phytochemistry, analytical aspects, medicinal attributes, specifications and stability of stigmasterol	6
Determination of testosterone/epitestosterone concentration ratio in human urine by capillary electrophoresis	6
Biotransformation of contraceptive drug desogestrel with Cunninghamella elegans, and anti-inflammatory activity of its metabolites	6
The synthesis of 4-chloro-17β-hydroxymethyl-17α-methyl-18-norandrosta-4,13-diene-3α-ol – Proposed long term metabolite (M4) of oralturinabol	6
Fungal transformation of norandrostenedione with Cunninghamella blakesleeana and anti-bacterial activity of the transformed products	6
The effect of transdermal 17β-estradiol combined with norethisterone acetate treatment on the lipid profile in postmenopausal women: A meta-analysis and systematic review of randomized controlled tria	6
In silico ADMET analysis of the A-, B- and D-modified androstane derivatives with potential anticancer effects	6
Type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3) inhibition and potential anti-proliferative activity of cholest-4-ene-3,6-dione in MCF-7 breast cancer cells	6
A synthesis of a rationally designed inhibitor of cytochrome P450 8B1, a therapeutic target to treat obesity	6
PDIA3 modulates genomic response to 1,25-dihydroxyvitamin D3 in squamous cell carcinoma of the skin	6
Antiproliferative activity of standardized phytopreparations from Ibervillea sonorae (S. Watson) Greene	6
Design and synthesis of hetero-steroids via ring-closing metathesis: Biological studies towards in vitro anticancer activity	6
Fat mass and obesity-associated gene expression and disease severity in type 2 diabetes mellitus	6
Anti-inflammatory pregnane-type steroid derivatives clathroids A-B from the marine Microcionidae sponge Clathria (Thalysias) vulpina: Prospective duel inhibitors of pro-inflammatory cyclooxygenase-2 a	6
Anabolic-androgenic steroids impair mitochondrial function and redox status in the heart and liver of mice	6