Tetrahedron Letters

Papers
(The TQCC of Tetrahedron Letters is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
Reactivity-based detection of nitrite ion: Rapid colorimetric and fluorometric response down to nM level84
Concise synthesis of pyridopyridazines52
Palladium-catalyzed regioselective arylation of 7-hydroxyflavone with diaryliodonium salts48
Synthesis of sulfur-containing polybromoindoles from the marine alga Laurencia brongniartii39
Synthesis of substituted benzoates using a rhodium-mediated Hopf cyclization of 1,3-dien-5-ynes accessed from 2-pyrones33
Facile and improved synthesis of the 2-O-β-d-glucopyranosyl-l-ascorbic acid30
Synthesis of 1,3‑dicarbonyl compounds bearing hetero-substituted α-quaternary carbon via Fe(II)-catalyzed alkylation with alkylsilyl peroxides25
Bromination of phenyl ether and other aromatics with bromoisobutyrate and dimethyl sulfoxide23
Formation of pyrroloindolines via the alkylation of tryptamines with trichloroacetimidates23
Photochemical direct C3 cyanoalkylation of quinoxalin-2(1H)-ones with cyclobutanone oxime esters under catalyst-free conditions22
Iodine-mediated direct α-amination of dimethyl methylmalonate using non-protected amines22
Transition-Metal-free Michael Addition/Denitrative cyclization of 2′-Nitrochalcones and thioacetamides for the synthesis of thioflavanones21
Graphical abstract TOC20
Tin(II)-chloride (SnCl2) mediated reduction of α,β-alkynyl carbonyl compounds20
Graphical abstract TOC18
Diverse ent-kaurane diterpenoids from Isodon henryi18
Decoration of GW9662 scaffold with a fragment-like hit via copper-catalyzed azide-alkyne cycloaddition reaction into peroxisome proliferator-activated receptor γ agonists18
Editorial Board18
Briavioid D, a rare 7β,8β-epoxybriarane from Briareum violaceum17
Substrate-controlled selective acylation of quinazolinones: Access to 2-benzamido-N-formylbenzamides and 3-benzoylquinazolinones17
New 8,17-epoxybriaranes from octocoral Briareum stechei (Kükenthal, 1908)17
Design, synthesis and biological evaluation of difluoroalkylated protoilludanes obtained by a practical radical cascade difluoroalkylation-cyclization reaction17
Editorial Board17
Graphical abstract TOC17
Convenient synthesis of 6-Amino-2-naphthol by Copper-catalyzed Ullmann reaction16
Visible light-induced 3H-indole hydrogenation using tetramethylethene as an inert hydrogen source16
A near-infrared self-assembled micellar nanoprobe for highly selective detection of hydrazine16
Manganese-catalyzed aerobic cross-dehydrogenative coupling of thiols with P(O)H compounds15
I2/CAN as an efficient reagent for the direct oxidation of tertiary Csp3-H to Csp3-OH: Synthesis of bis(N-methyl-7-azaindol-3-yl) (phenyl) methanol from 3,3′-(phenyl methylene)-bis(N-methyl-7-azaindol15
Preparation of β-hydroxyketones (aldols) from the alkylation of O-silyl aryl cyanohydrins with epoxides15
Microwave assisted rapid synthesis of bicyclo aza-sulfone derivatives from aldehydes via aldoxime formation followed by Michael addition-1,3-dipolar cycloaddition with divinyl sulfone in one-pot15
Catalyst-free direct ring-opening of cyclic aldimines with aliphatic primary amines to construct o-hydroxy schiff bases14
A sustainable approach to microwave assisted synthesis of 2-(het)/arylquinazolin-4(3H)-ones via ionic liquid supported Cu(II) catalyst14
Synthesis of 9- and 12-nitro conjugated linoleic acid: Regiospecific isomers of naturally occurring conjugated nitrodienes14
Synthesis of Poly-substituted 2-Hydroxycyclobutanones via Norrish–Yang Photocyclization/1,2-Methyl Migration: Scope and limitations14
A robust method using reducing inorganic salts for preventing the desulfurization of phosphorothioate oligonucleotides during the cleavage and deprotection step14
An interesting fluorescent probe with aggregation-induced emission for highly sensitive and selective detection of Hg2+13
Alternate end-game strategies towards Nirmatrelvir synthesis: Defining a continuous flow process for the preparation of an anti-COVID drug13
A new simple fluorescent probe for imaging endogenous hydrogen peroxide in RAW 264.7 cells13
Asymmetric synthesis of pyrrolo[2,3–b]indole scaffolds by organocatalytic [3 + 2] dearomative annulation13
Vicinal diphosphorylation of enaminones with diaryl phosphine oxides via AlCl3-mediated C N bond cleavage13
Carboranes meet photochemistry: Recent progresses in light-mediated cage functionalisation13
Design and synthesis of naphthalimide-based CO fluorescent probes realizing tricolor detection and turn-on/off response13
Thermally generated bromine “Cation Pool-”mediated oxidation of indole to 2-oxindole13
Recent progress in chemistry of non-benzenoid carbohelicenes13
Synthesis of the 5/6 fused-spiro tricyclic framework of manginoid A13
Greener synthesis of Pyrroloacridine-1(2H)-one and 1,8-Dioxodecahydroacridine derivatives: Ascorbic acid mediated OrganocatalyticApproach13
Recent developments in the synthesis of bioactive boron-containing compounds13
Graphical abstract TOC continued12
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Computational examination of a proposed highly-strained natural product12
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Effect of organic solvents on asymmetric reduction of β-keto esters using cyanobacterium Synechocystis sp. PCC 680312
Graphical Abstract TOC Continued12
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Synthesis of neodesmosine-d4 and quantitative LC-MS/MS analysis of neodesmosine in biological samples11
Rh(III)-catalyzed C(sp2) H arylation and esterification cascade reaction of aryl acids with organic boronates11
A concise synthesis of (-)-dihydrospirotryprostatin B via tandem Michael addition11
Synthesis of polyfluorinated aromatic ethers and thioethers by synergistic cleavage of C-B bond and C-F bond of B(C6F5)311
Graphical abstract TOC11
The application and development of cyanating reagents in asymmetric cyanation reactions11
Synthesis of tetrahydropyrans via an intermolecular oxa-michael/michael stepwise cycloaddition11
Reaction of 3-Br-coumalate with alkynals11
Copper-catalyzed radical cascade cyclization of 2-(allyloxy)arylaldehydes towards chroman-4-one derivatives11
Approach to α-fluorinatedacetoxy ketones by fluoroacetoxylation of alkynes with hyper-valent iodine(III) reagents11
The first enantioselective total synthesis of the eremophilane-type sesquiterpenoid (−)-peniroqueforin C11
Peptide oxo-esters for ligation of peptide hydrazide at Gln and Asn sites11
Graphical abstract TOC10
DFT study on mechanism of nickel-catalyzed decarbonylative reductive alkylation of aroyl fluorides with alkyl bromides10
Cyclocondensation of o-aminophenols with α-ketothioesters in acidic media: A facile synthesis of 2-acylbenzoxazoles10
Visible light-promoted alkylation of electron-deficient alkenes with alkylsilyl peroxides10
Visible light-induced pericyclic cascade reaction for the synthesis of eight-membered rings10
Palladium-catalyzed borylation of aryl bromides and chlorides using phosphatrioxa-adamantane ligands10
Faster and greener parallel chemical reaction work-up using ‘sponge’ extraction10
Synthesis of spiro[piperidine-4,3′-pyrrolo[3,4-c]quinolines via 1,3-dipolar cycloaddition of azomethine ylides and 3-Nitro-2(1H)-quinolones10
2-(Hydroxypropan-2-yl)diphenylphosphine oxide (HDPO): A convenient precursor to diphenylphosphine oxide (DPO)10
Development of a cationic aggregate induced emission fluorescent probe for detection of aromatase10
Organocatalytic Mannich type reactions of glyoxylate imines and related compounds10
I2–DMSO-mediated formal [3 + 1 + 2] synthesis of pyrimido[1,2-b]indazole using 1,4-dithiane-2,5-diol as a surrogate of ethylene10
Graphical abstract TOC10
Synthesis and studies on the photophysical/biophysical properties of triazolylfluorene-labeled 2′-deoxyuridines10
Visible-light-induced trifluoromethylation/cyclization of unactivated alkenes: Synthesis of CF3-substituted fused tricyclic indoles10
New tetracyclic and pentacyclic isomalabaricanes from the marine sponge Rhabdastrella globostellata (Carter, 1883)10
Catalyst identification for chemoselective phosphorylation of phenols and aliphatic alcohols10
Chiral phosphoric acid-catalyzed reaction between C-alkynyl imine precursor and thiol: Access to highly enantioenriched alkynyl isoindolinones with N,S-ketal framework10
Total synthesis of merodesmosine10
“Iron catalyzed alkynylation of thiohydantoins with terminal alkyne via cross-dehydrogenative coupling (CDC)”10
Graphical abstract TOC10
Visible-light-promoted trifluoromethylation/arylation of unactivated alkenes with Togni-CF3 for the synthesis of trifluoromethylated pyrrolo[1,2–a]indoles10
Graphical abstract TOC10
Visible-light-mediated radical addition/cyclization tandem reaction for the synthesis of 3-bromomethyl-3,4-dihydroisocoumarins10
A divergent approach to synthesize C7 epoxyquinones from (–)-shikimic acid10
I2 and aqueous TBHP induced aerial oxidative coupling of 2-aminobenzyl alcohols and nitriles: A novel metal-free route towards quinazolines synthesis10
Palladium catalyzed amidation of phenyl carboxylates and anilines using aqueous micellar catalysis10
Highly effective one pot reaction from α-hydrazonoesters to give anilinoesters via α-diazoesters10
1,4,2-Diazaborole-type heterocycle from 2H-azirine-2-carboxylate and [(alkylamino)methyl]trifluoroborate10
(+)/(−)-Alexanoid A, a pair of enantiomeric sesquiterpenoid with a novel 5/6/6 tricyclic backbone from the stem of Syringa pinnatifolia9
Visible light-activated ruthenium-catalysed direct arylation at ambient temperature9
Graphical abstract TOC9
Silver-catalyzed cross-dehydrogenative coupling of benzoxazine-2-ones with resorcinol9
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Blue light induced [2,3]-sigmatropic rearrangement reactions of tosylhydrazones9
Iron-catalyzed oxidative amidation of acylhydrazines with amines9
2-Guanidinoethanesulfonyl sesquiterpenes from the marine sponge Agelas nakamurai9
Aerobic copper-catalyzed homo-coupling of azaallyl anions: A facile access to vicinal diamines9
Graphical abstract TOC continued9
Efficient total synthesis of three alpinoids via the Au(I)-catalyzed Meyer-Schuster rearrangement9
First total synthesis of aspergillolide9
B(C6F5)3-catalyzed regio- and stereoselective cyanation of isatogens and their derivatives9
One pot synthesis of carboxylic acid, ester, and amide derivatives from iodoarenes in aqueous solubilized systems using sodium oleate as surfactant at room temperature9
GRAPHICAL ABSTRACT TOC continued9
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Tandem Prins bicyclization for the synthesis of tetrahydropyran containing spirocompounds9
N,N'-Disulfonylhydrazines: A novel source of sulfonyl moieties for synthesis of diaryl sulfones9
Graphical abstract TOC continued9
Simple, green and one pot new strategy for synthesis of the phthalimide derivatives9
Synthesis of spiroisoxazoline oxindoles by base-promoted annulation of oxime esters and isatins9
Synthesis of quinazolinone derivatives with a seven‐membered ring using borrowing hydrogen methodology9
Iron-catalyzed one-pot tandem oxidation/acylation/dearomatization of biaryl ynones with benzyl alcohols: access to diversified acylated spiro[5.5]trienones9
Graphical abstract TOC9
Photoredox-catalyzed cross-coupling of N-indolylacetic acids with nitrones: Access to indole-N-ethylamines9
Applications of phenalenyl-based Cu(II) complex towards direct oxidation of aldehydes to esters9
Studies towards DIAD promoted N-demethylation of N,N-dimethylanilines9
Graphical abstract TOC9
Recent advances in development of bibenzo[c]thiophene derivatives for application in functional materials9
Kinetic and thermodynamic concepts as synthetic tools in supramolecular chemistry for preparing macrocycles and molecular cages9
Rhenium-catalyzed disproportionation of allylic alcohols and selective reduction of allylic alcohol with secondary alcohol9
Efficient access to multi-substituted 1-aminoisoquinolines via Rh(III)-catalyzed oxidative annulation of aminopyridine pivalamides with internal alkynes9
Nitration of deactivated aromatic compounds using Lithium nitrate9
An efficient and convenient reaction system based on MnAl layered double oxide for the aerobic oxidation of alkylarenes9
A convenient ammonium chloride facilitated mild and efficient synthesis of Benzazepinoindole derivatives through a Pictet-Spengler reaction*8
Graphical abstract TOC8
Dipyridylamine-acetamide (Dpaa): A primary amine protecting group orthogonally cleavable under acidic conditions in the presence of t-butyloxycarbonyl (Boc) and t-butylester8
Editorial Board8
Facile access to sodium arylsulfinates via nucleophilic C S bond cleavage of 2-(arylsulfonyl)pyrimidines8
Development of 1,3a,6a-triazapentalene derivatives as practical erasable fluorescent cell staining reagents8
Brønsted acid-catalyzed selective alkylation of tetrazoles with acetone8
Graphical abstract TOC8
Editorial Board8
Contents continued8
A concise approach for the synthesis of the tetracyclic framework of Lycibarbarines A and B8
Methodologies for the synthesis of 3,4-ethylenedithiothiophene (EDTT) and its derivatives for use as semiconductor materials8
Stable planar chirality of arylated pillar[6]arene and its thermal response8
Efficient access to spiro[quinazoline-thiophen](thi)ones via acetic acid mediated [3 + 2] annulation of quinazolin(thi)one enamines with dithianediol8
Development of a simple and safe route to C-3 arylated 1H-pyrazoles8
Editorial Board8
Copper(I) bromide-mediated C(sp2)-H direct sulfonylation of tertiary enamides for synthesis of (E)-β-amidovinyl sulfones8
Reactivity insights from the allylation of substituted phenols with 2-allyloxy-1-methylpyridinium triflate8
Iodotriphenylphosphonium iodide mediated deprotection of aryl alkyl ethers under metal-free and neutral conditions8
Concise synthesis of (±)-gomadalactone A8
Visible-light promoted allylation of N-substituted tetrahydroisoquinoline using riboflavin tetra-acetate as photocatalyst8
Synthesis of 1,3-benzooxazine spirosuccinimides through the cascade reaction of 2-phenoxy-1H-benzo[d]imidazoles with maleimides8
24-Dehydrohippuristanol, a cytotoxic spiroketal steroid from Isis hippuris8
Elemental sulfur promoted condensation of indoles and 1,2-phenylenediamines8
Access to α,α-dihaloacetophenones through anodic C C bond cleavage in enaminones8
Synthesis and cytotoxicity evaluation of retro-inverso analogue of antitumor bicyclic hexapeptide RA-VII8
Formation of triarylphosphines via P H/C F cross coupling reactions catalyzed by nickel8
Erratum to “Efficient thiocyanation of aromatic compounds using NH4SCN, DMSO and H2SO4” [Tetrahedron Lett. 101C (2022) 153929]8
Editorial Board8
Graphical abstract TOC8
Towards the total synthesis of aleurodiscal8
Organoborane-catalyzed selective 1,2-reduction of alkynones with hydride transfer: Synthesis of benzyl alkynes8
Visible-light-promoted sodium iodide-mediated sulfenylation of imidazo[1,2-a]pyridines heterocycle using thiosulfate as odorless electrophilic arylsulphenyl source8
Multicomponent reaction between (Z)-chloroximes, isocyanides and NH-heterocyclic rings8
A turn-on fluorescent probe for palladium(II) detection with a large Stokes shift and lysosomes-targeting ability8
Graphical abstract TOC8
Pentafluorophenol (C6F5OH) catalyzed Regioselective annulation for the synthesis of tetracyclic Dihydrochromeno indoles8
Synthesis of (1Z)-deacylcnicin8
Recent advances in site-selective C H functionalization of naphthalenes: An update 2020–20248
Teuchamaedol A, a new neo-clerodane diterpenoid from the aerial parts of Teucrium chamaedrys8
Spiroindimicin model studies reveal a facile route to cyclopenta[c]pyrazoles8
On the protonation and deuteration of 2-methylmercaptothiophene: Formation of a 2′,3′-dihydro-2,3′-bithiophene dimer8
Graphical abstract TOC8
Trimethyl borate assisted chemoselective synthesis 1,5-dihydrodiazepines from hemicurcuminoids and o-phenylenediamines8
Graphical abstract TOC continued8
Mukaiyama reagent: An efficient reaction mediator for rapid synthesis of 1,2-disubstituted-1H-benzo[d]imidazoles7
Contents continued7
Synthesis of Phenanthridine derivatives from Arynes and Ketimines via aza-Diels-Alder/decarboxylation reactions7
Copper-catalyzed γ-selective yne-allylic substitution of vinyl ethynylethylene carbonates towards a formal [3 + 3] cycloaddition7
Cynotofuranoside A-C: Uncommon C21-steroidal furanosides derived from the acid hydrolysate of Cynanchum otophyllum roots7
Metal-free, visible-light-induced C(sp2)-H functionalization/C O bond formation for the synthesis of flavones using air as an oxidant7
Metal-free oxidative ketonization–olefination of indoles by cross-coupling with 1,3-dicarbonyl substrate7
Synthesis of carbacycloisodityrosine, an analogue of cycloisodityrosine in antitumor bicyclic hexapeptide RA-VII7
Metal- and solvent-free synthesis of 2-benzyl-3-arylquinoline using a pseudo-three-component reaction7
Graphical abstract TOC7
Continuous flow synthesis of C-acyloxy-substituted aziridines in microchannel reactor: Addition of carboxylic acids to 2-methylenaziridines7
Transformation of brucine into trifluoromethyl neobrucine using the homoleptic nickel catalyst [Ni(CF3)4]2−7
Biosynthesis of fusicoccane-type diterpenoids featuring a 5–8–5 tricyclic carbon skeleton7
Synthesis of xylose-binding cyclic octalipopeptides burkholdine-1213 analogues7
Synthesis of 1,3-thiazolidine-2-thiones using CS2 and epoxy amines7
Diastereoselective synthesis of novel alkaloid-like 1,2,3,3a,7b,12-hexahydroindeno[2′,1′:2,3]indeno[1,2-c]pyrroles7
Synthesis of quinoline fused 1,2,3-triazole derivatives via continuous CuAAC and C H arylation; anti-breast cancer, anti-EGFR and HER2 activities, computational studies7
Visible-light-induced photocatalyst-free intramolecular sp3 C–H oxidation of 2‑alkyl benzamides7
Editorial Board7
Graphical abstract TOC7
Facile synthetic route to isoxazoles from β-sulfinyl- and β-sulfonyl-cyclohexenones via regioselective nitrile oxide cycloaddition and in-situ elimination7
Electrochemical oxythiocyanation of ortho-olefinic amides: Access to diverse thiocyanated benzoxazines7
Silver-catalyzed regioselective synthesis of (E)-vinyl sulfones from nitroolefins and thiophenols7
Merging Halogen-Atom transfer with transition metal catalysis7
Ag(I)-catalyzed synthesis of (E)-alkenyl phosphonates by oxidative coupling of H-phosphites with β-nitroolefins7
CuBr2 catalyzed alkynylation of tertiary methylamine with terminal alkyne using aqueous TBHP under mild conditions7
The ferrocenylation reaction of olefins and alkynes with a novel ferrocenyl sulfonium salt based on thianthrene skeleton7
Homogeneous organic reductant based on 4,4′- Bu2-2,2′-bipyridine for cross-electrophile coupling7
Hydrosilylation of ketones catalyzed by novel four-coordinate copper(I) complexes under mild conditions7
Electrochemical-induced radical allylation via the fragmentation of alkyl 1,4-dihydropyridines7
S-Benzyl-N,N'-diphenyl substituted isothiouronium iodide as a highly efficient organocatalyst for transfer hydrogenation of 2-substituted quinolines7
Oxidative [3 + 2] cycloaddition of triazenes and trisubstituted dichloroalkenes7
Graphical abstract TOC7
Stereoselective synthesis of resorcylic acid lactone Cochliomycin B7
10 Gram-scale synthesis of TY-Phos ligand and its application in carbene insertion of Si-H bonds7
Rearranged and enantiomeric alkaloids from Cephalotaxus sinensis7
3-Carboxamide oxindoles as 1,3-C,N-bisnucleophiles for the highly diastereoselective synthesis of CF3-containing spiro-δ-lactam oxindoles featuring acyl at the ortho-position of spiro carbon atom7
Electrochemical synthesis of 1,2,3-trisubstituted pyrroles from β-dicarbonyl compounds, aldehydes and amines via radical addition reaction7
Iron-catalyzed intramolecular reductive cyclization of o-nitroarenes to indoles under visible light irradiation7
Implementation of Zincke reaction in one-pot synthesis of switchable, Ag+ and Hg2+ sensing aza-merocyanines based on α-aminopyridin-3,5-dicarbonitrile moiety7
A copper catalyzed Doyle–Kirmse reaction for the concise and effective preparation of multifunctional 3-allyl-3-(thio) succinimides7
PPh3-catalyzed chemoselective reduction of aldehydes to alcohols7
Synthesis of π-extended aza[5]helicene bearing AuI-acetylide at the outside or the inside of the helix7
Electrochemical synthesis of 2,5-disubstituted-1,3,4-thiadiazoles via oxidative cyclization of benzothiohydrazides and aldehydes catalyzed by tetra-n-butylammonium iodide7
An improved process for the release of synthetic DNA sequences from a solid-phase capture support7
Xanthene and citrinin derivatives from the endophytic fungus Penicillium sp. T2-117
Editorial Board7
Fluoroethylthiolation of indoles with iodofluoroethane7
Photocatalytic annulative trifluoromethyletherification of 1,6-enynes for accessing 1-indanones7
Hydroxymethylation of active methenyl compounds: DMSO as methylene source and H2O as oxygen source7
BF3.OEt2 catalysed synthesis of diverse 9‑fluorenlidene appended indole-1-oxides and spiro[fluorene-9,10′-indeno[1,2-b]indol]-5′-yl) ethanones from 9-(phenylethynyl)-fluoren-9-ol and nitrosobenzene6
Transition-metal-free, direct C H radical trifluoromethylation of nitroimidazoles with Togni’s reagent6
Direct substitution of the hydroxy group of alcohols with N-nucleophiles mediated by the substoichiometric amount of Selectfluor™ F-TEDA-BF as a precatalyst under mild reaction conditions6
Pd-catalyzed Site-selective direct arene C   H arylation of Pyrrolo[2,3-d]pyrimidine derivatives with aryl iodides6
Synthesis of N-methoxy-1‑phosphoryloxy imidates through a copper-catalyzed cross-dehydrogenative coupling of N-methoxylamides with phosphites6
Design and synthesis of ether derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment6
Graphical abstract TOC6
O-Alkylation of hydroxypyridines and derivatives via transient alkyl diazonium species6
Editorial Board6
Direct synthesis and optical absorbance studies of the first representatives of 3-ylidenemalononitrile derivatives of 2-oxopyrroles containing a phenol moiety6
Application of multi-wall carbon nanotubes supported l-proline in continuous flow catalysis6
Straightforward access to heterofused ε-sultams annelated on face [d]6
Copper-catalyzed enantioselective 1,4-hydroboration of α,β-unsaturated amides6
Pyran-based derivative: non-conventional organogel and tri-colored high-contrast mechanochromism6
Graphical abstract TOC6
Total synthesis of halogenated spirocyclic polyketide (±)-actinospirol A6
A new method to synthesize 1,2,4-oxadiazoles by using DMTMM as condensing agent6
Indole/oxazolone functionalized coumarins as pH-sensitive fluorescent kinase inhibitors6
Stereoselective Mannich reaction catalyzed by tetrahydroindolo[3,2-b]indole under solvent-free conditions6
Graphical abstract TOC6
Editorial Board6
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