Toxicology and Applied Pharmacology

Article	Citations
Complanatoside A disrupts copper homeostasis and induces cuproptosis via directly targeting ATOX1 in prostate cancer	96
Engineering human cerebral organoids to explore mechanisms of arsenic-induced developmental neurotoxicity	69
Heritable dysregulation of DNA methylation may underlie the diabetogenic effects of paternal preconception exposure to inorganic arsenic in C57BL/6J mice	63
Involvement of nuclear atrophy of binucleated hepatocytes in the large micronucleus formation induced by rat hepatocarcinogen acetamide	55
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Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model	45
Urinary polycyclic aromatic hydrocarbon, arsenic, and metal exposure and correlation with emphysema in smokers	42
Development of quercetin-loaded PVCL–PVA–PEG micelles and application in inhibiting tumor angiogenesis through the PI3K/Akt/VEGF pathway	41
Neuregulin 1 improved gastric motility and reduced gastric inflammation by activating the α7nAChR through the cholinergic anti-inflammatory pathway in diabetic rats	41
Neurotoxicity study of cenobamate-induced zebrafish early developmental stages	40
Post-transplantation cyclophosphamide and cyclosporine A versus methotrexate and cyclosporine A for graft-versus-host disease prophylaxis after allogeneic peripheral stem cell transplantation in adult	38
Berberine alleviated contrast-induced acute kidney injury by mitophagy-mediated NLRP3 inflammasome inactivation in a mice model	37
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Arsenite inhibits M2a polarization of macrophages through downregulation of peroxisome proliferator-activated receptor gamma	34
An insight about the mechanism of action (MoA) of R-bicalutamide on the androgen receptor homodimer using molecular dynamic	34
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Functional, proteomic and phenotypic in vitro studies evidence podocyte injury after chronic exposure to heparin	30
The effect of shikonin on the metabolism of lapatinib in vitro, and in vivo	29
Exosome-derived miR-5p-72106_14 in vascular endothelial cells regulates fate determination of BMSCs	29

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Elucidating the relationship between metabolites and breast cancer: A Mendelian randomization study	28
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Subclinical markers of cardiovascular toxicity of benzene inhalation in mice	27
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cas	27
Exposure to the bromodomain inhibitor N-methyl pyrrolidone blocks spermatogenesis in a hormonal and non-hormonal fashion	27
Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer	27
The ABCB1 and ABCG2 efflux transporters limit brain disposition of the SYK inhibitors entospletinib and lanraplenib	27
Editorial Board	27
Modulation of insulin signaling pathway genes by ozone inhalation and the role of glucocorticoids: A multi-tissue analysis	26
The pharmacologic and toxicologic characterization of the potent and selective KRAS G12D inhibitors ERAS-4693 and ERAS-5024	26
Editorial Board	26
Effect of post-gastrulation exposure to acrylamide on chick embryonic development	25
Role of microbial microbes in arsenic bioaccumulation and biotransformation in mice	25
Transcriptomic re-analyses of human hepatocyte spheroids treated with PFAS reveals chain length and dose-dependent modes of action	25
Seizure suppression and neuroprotection in soman-exposed rats following delayed intramuscular treatment of adenosine A1 receptor agonist as an adjunct to standard medical treatment	25
Genomic methylation variations predict the susceptibility of six chemotherapy related adverse effects and cancer development for Chinese colorectal cancer patients	25
Raddeanin A synergistically enhances the anti-tumor effect of MAP30 in multiple ways, more than promoting endosomal escape	24
Advanced oxidation protein products upregulate ABCB1 expression and activity via HDAC2-Foxo3α-mediated signaling in vitro and in vivo	24
Association of urinary arsenic, polycyclic aromatic hydrocarbons, and metals with cancers among the female population in the US	24
The role of microRNAs in regulating cadmium-induced apoptosis by targeting Bcl-2 in IEC-6 cells	24
Editorial Board	23
Estimated sensitivity profiles of lung cancer specific uncommon BRAF mutants towards experimental and clinically approved kinase inhibitors	23
The ponatinib/gossypol novel combination provides enhanced anticancer activity against murine solid Ehrlich carcinoma via triggering apoptosis and inhibiting proliferation/angiogenesis	23
Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-κB signaling pathway	23
ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop	23
Infection and disruption of placental multidrug resistance (MDR) transporters: Implications for fetal drug exposure	23
Resveratrol alleviates inflammatory bowel disease by inhibiting JAK2/STAT3 pathway activity via the reduction of O-GlcNAcylation of STAT3 in intestinal epithelial cells	22
Neuroprotective effects of ibudilast against tacrolimus induced neurotoxicity	22
A computational model of the crosstalk between hepatocyte fatty acid metabolism and oxidative stress highlights the key enzymes, metabolites, and detoxification pathways in the context of MASLD	22
Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX	21
Exploring the potential neurotoxicity of vaping vitamin E or vitamin E acetate	21
Editorial Board	21
Enhancing toxicity prediction for natural products in herbal medicine and dietary supplements: Integrating (Q)STR models and in vitro assays	21
Arsenic as an immunotoxicant	21
Corrigendum to “Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6) are associated with long term tramadol treatment-induced oxidative damage and hepatotoxicity” [Toxicology and Applied Pharmacology	21
Levamisole, a cocaine cutting agent, induces acute and subchronic systemic alterations in Wistar rats	21
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Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress	20
Integrative analysis of metabolomics and proteomics reveals mechanism of berberrubine-induced nephrotoxicity	20
Re-positioning of low dose paclitaxel against depressive-like behavior and neuroinflammation induced by lipopolysaccharide in rats: Crosstalk between NLRP3/caspase-1/IL-1β and Sphk1/S1P/ NF-κB signali	20
TRAIL produced by SAM-1-activated CD4+ and CD8+ subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors	20
Editorial Board	20
Prepubertal to adulthood exposure to low doses of glyphosate-based herbicide increases the expression of the Havcr1 (Kim1) biomarker and causes mild kidney alterations	20
Myricetin inhibits 4 T1 breast tumor growth in mice via induction of Nrf-2/GPX4 pathway-mediated Ferroptosis	20
Molnupiravir; molecular and functional descriptors of mitochondrial safety	19
Azoospermia and multi-organ damage in juvenile rats exposed to α-Terpineol from weaning to sexual maturity	19
Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis	19
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Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3	19
Lonicerin protects pancreatic acinar cells from caerulein-induced apoptosis, inflammation, and ferroptosis by activating the SIRT1/GPX4 signaling pathway	19
A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports	19
Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells	18
Differential inhibition of sildenafil and macitentan on saxagliptin metabolism	18
Effects of electronic cigarette E-liquid and device wattage on vascular function	18
Anti-inflammatory effects of cannabidiol in early stages of neuroinflammation induced by high-fat diet in cerebral cortex of rats	18
KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice	18
Sodium dichloroisocyanurate toxicity in rats during a 90-day inhalation toxicity study	18
Crosstalk between the aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated receptor gamma (PPARγ) as a key factor in the metabolism of silver nanoparticles in neuroblastoma (SH-SY	18
Examination of the exposome in an animal model: The impact of high fat diet and rat strain on local and systemic immune markers following occupational welding fume exposure	18
Wood smoke particle exposure in mice reduces the severity of influenza infection	17
Safety and toxicology assessment of sodium nitrite administered by intramuscular injection	17
Cardiac toxicity from bisphenol A: Are electrophysiology and calcium handling perturbations dose-dependent?	17
Ethoxy-erianin phosphate and afatinib synergistically inhibit liver tumor growth and angiogenesis via regulating VEGF and EGFR signaling pathways	17
Delineation of the molecular mechanisms underlying Colistin-mediated toxicity using metabolomic and transcriptomic analyses	17
Comparison of the drug-drug interactions potential of ibrutinib and acalabrutinib via inhibition of UDP-glucuronosyltransferase	17
Novel insights into the N6-methyladenosine RNA modification and phytochemical intervention in lipid metabolism	17
Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress	16
Immunosuppression, oxidative stress, and apoptosis in pig kidney caused by ammonia: Application of transcriptome analysis in risk assessment of ammonia exposure	16
Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property	16
The endocrine disruptor DE-79 alters oxytocinergic transmission and sexual behavior expression in male rats	16
The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval	16
Co-administration of CSL112 (apolipoprotein A-I [human]) with atorvastatin and alirocumab is not associated with increased hepatotoxic or toxicokinetic effects in rats	16
Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio	16
Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells	16
Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy	16
Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression	16
Neonatal metformin short exposure inhibits male reproductive dysfunction caused by a high-fat diet in adult rats	16
Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells	16
Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways	15
Can exposure to lisdexamfetamine dimesylate from juvenile period to peripubertal compromise male reproductive parameters in adult rats?	15
Environmental uranium exposures and cytokine profiles among mother-newborn baby pairs from the Navajo Βirth Cohort Study	15
Integrative description of changes occurring on zebrafish embryos exposed to water-soluble crude oil components and its mixture with a chemical surfactant	15
Epicatechin exerts dual action to shield sickling and hydroxyurea-induced myelosuppression: Implication in sickle cell anemia management	15
Bisphenol A analogues induce a feed-forward estrogenic response in zebrafish	15
The path via pathway-based approaches towards safety assessment: A concise review	15
Integrated bioinformatic analysis to understand the association between phthalate exposure and breast cancer progression	15
A novel genetically modified mouse seizure model for evaluating anticonvulsive and neuroprotective efficacy of an A1 adenosine receptor agonist following soman intoxication	14
The 11th Conference on metal toxicity and carcinogenesis	14
Liposomal methemoglobin as a potent antidote for hydrogen sulfide poisoning	14
Ganoderic acid T, a Ganoderma triterpenoid, modulates the tumor microenvironment and enhances the chemotherapy and immunotherapy efficacy through downregulating galectin-1 levels	14
Decreased vascular contraction and changes in oxidative state in middle–aged Wistar rats after exposure to increased levels of dietary zinc	14
Epigallocatechin gallate ameliorates retinal pigment epithelial cell damage via the CYFIP2 /AKT pathway	14
ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT	14
Integrated analysis of microRNA expression profiles and function network in mice testes after low dose lead exposure from early puberty	14
Up-regulation of RNA m6A methyltransferase like-3 expression contributes to arsenic and benzo[a]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis	14
Association of lipid-modifying therapy with risk of obstructive sleep apnea: A drug-target mendelian randomization study	14
Heavy metals, oxidative stress, and the role of AhR signaling	14
Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents	14
Tanshinone IIA modulates cancer cell morphology and movement via Rho GTPases-mediated actin cytoskeleton remodeling	14
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET	14
Role of MST2/YAP1 signaling pathway in retinal cells apoptosis and diabetic retinopathy	14
Toxicology profile of a novel GLP-1 receptor biased agonist-SAL0112 in nonhuman primates	14
Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach	14
Embryonic exposure to acetamiprid insecticide induces CD68-positive microglia and Purkinje cell arrangement abnormalities in the cerebellum of neonatal rats	14
Nimodipine inhibits intestinal and aortic smooth muscle contraction by regulating Ca2+-activated Cl− channels	14
Pharmacology and molecular modeling studies of sulfoxaflor, flupyradifurone and neonicotinoids on the human neuronal α7 nicotinic acetylcholine receptor	13
1,2,4-trihydroxybenzene induces non-apoptotic cell death via the structural damage of intracellular organelles	13
Exposure to topiramate and acetazolamide causes endocrine disrupting effects in female rats during estrus	13
An in vitro-in silico workflow for predicting renal clearance of PFAS	13
Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat	13
Chloroorganic (DDT) and organophosphate (malathion) insecticides impair the motor function of the bovine cervix	13
Duloxetine protected indomethacin-induced gastric mucosal injury by increasing serotonin-dependent RANTES expression and activating PI3K-AKT-VEGF pathway	13
Downregulation of mesenteric afferent sensitivity following long-term systemic treatment of vincristine in mice	13
Effect of substituents at the C3´, C3´N, C10 and C2-meta-benzoate positions of taxane derivatives on their activity against resistant cancer cells	13
Muscarinic and nicotinic receptors stimulation by vagus nerve stimulation ameliorates trastuzumab-induced cardiotoxicity via reducing programmed cell death in rats	13
Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard	13
Hepatotoxicity or hepatoprotection of emodin? Two sides of the same coin by 1H-NMR metabolomics profiling	13
Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys	13
Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices	13
Strengths and limitations of the worm development and activity test (wDAT) as a chemical screening tool for developmental hazards	13
Melatonin prevents pulmonary fibrosis caused by PM2.5 exposure by targeting epithelial-mesenchymal transition	13
Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet	13
Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses	13
Corrigendum to “Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis” [Toxicology and Applied Pharmacology 324 (2017) 12-25]	12
Corrigendum to “Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats” [Toxicology and Applied Pharmacology, 282 (2015) 297–310]	12
Inhibition of CDGSH iron‑sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation of the NRF2/SLC7A11/GPX4 pathway	12
Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein	12
Identification of novel and potential PPARγ stimulators as repurposed drugs for MCAO associated brain degeneration	12

Thymoquinone inhibits Neuroinflammatory mediators and vasoconstriction injury via NF-κB dependent NeuN/GFAP/Ki-67 in hypertensive Dams and F1 male pups on exposure to a mixture of Bisphenol-A analogue	12
Mitochondrial iron deficiency mediated inhibition of ecdysone synthesis underlies lead (Pb) induced developmental toxicity in Drosophila melanogaster	12
Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway	12
Corrigendum to “Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells” [Toxicology and Applied Pharmacology 319 (20	12
New insights into the mechanisms underlying 5-hydroxymethylfurfural-induced suppression of testosterone biosynthesis in vivo and in vitro	12
Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development	12
TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis	12
Nrf2 deficiency aggravates hepatic cadmium accumulation, inflammatory response and subsequent injury induced by chronic cadmium exposure in mice	12
Corrigendum to “The role of PTEN in regulation of hepatic macrophages activation and function in progression and reversal of liver fibrosis” [Toxicology and Applied Pharmacology 317 (2017) 51–62]	12
Epigenetic modifications control CYP1A1 Inducibility in human and rat keratinocytes	12
Corrigendum to “PKC-δ-dependent mitochondrial ROS attenuation is involved as 9-OAHSA combats lipoapotosis in rat hepatocytes induced by palmitic acid and in Syrian hamsters induced by high-fat high-ch	12
d-Tetramethrin causes zebrafish hepatotoxicity by inducing oxidative stress and inhibiting cell proliferation	12
Hydroxysafflor yellow A protects against colitis in mice by suppressing pyroptosis via inhibiting HK1/NLRP3/GSDMD and modulating gut microbiota	12
Misrepresentation of mouse genotypes: A call for precision	12
Hepatic and ovarian effects of perfluorooctanoic acid exposure differ in lean and obese adult female mice	11
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF	11
SNAI1-expressing fibroblasts and derived-extracellular matrix as mediators of drug resistance in colorectal cancer patients	11
Serum levels of IL-6/IL-10/GLDH may be early recognition markers of anti-tuberculosis drugs (ATB) -induced liver injury	11
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis	11
Integrated network toxicology, transcriptomics and gut microbiomics reveals hepatotoxicity mechanism induced by benzo[a]pyrene exposure in mice	11
Hainanolide inhibits the progression of colon cancer via inducing the cell cycle arrest, cell apoptosis and activation of the MAPK signaling pathway	11
Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments	11
Role of respiratory uncoupling in drug-induced mitochondrial permeability transition	11
Long non-coding RNA CYTOR modulates cancer progression through miR-136-5p/MAT2B axis in renal cell carcinoma	11
Low-dose spironolactone combats dyslipidemia and hepatic inflammation by modulating PCSK9 in rat model of polycystic ovarian syndrome	11
The role of NUPR1 in response to stress and cancer development	11
Loss of the aryl hydrocarbon receptor increases tumorigenesis in p53-deficient mice	11
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis	11
The HDAC inhibitor HFY-4A improves TUSC2 transcription to induce immunogenic cell death in breast cancer	11
Benchmark dose-response analyses for multiple endpoints in drug safety evaluation	10
The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1)	10
Platinum-based chemotherapy induces demyelination of Schwann cells in oral squamous cell carcinoma treatment	10
Effects of 1, 2-bis (2,4, 6-tribromophenoxy) ethane and bis (2-ethylhexyl) tetrabromophthalate on serum metabolic and lipid profiles in male rats	10
Toxic element contaminations of prenatal vitamins	10
Chromium distribution in an oropharyngeal aspiration model for hexavalent chromium in rats	10
Toxic effects of prenatal azithromycin exposure on fetal adrenal gland in mice: The role of stage, dose and course of treatment	10
Corrigendum to “Casticin inhibits stemness of hepatocellular carcinoma cells via disrupting the reciprocal negative regulation between DNMT1 and miR-148a-3p” [Toxicology and Applied Pharmacology 396 (	10
Effects of melatonin on the pharmacokinetics and amino acid metabolism profile of vigabatrin in rats	10
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Inflammation resolution in environmental pulmonary health and morbidity	10
Isorhynchophylline ameliorates paraquat-induced acute kidney injury by attenuating oxidative stress and mitochondrial damage via regulating toll-interacting expression	10
Effects of combined continuous renal replacement therapy and ulinastatin on cytokine levels and clinical outcomes in patients with sepsis	10
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade	10
Dendrobine protects HACAT cells from H2O2-induced oxidative stress and apoptosis damage via Nrf2/Keap1/ARE signaling pathway	10
Stage-, dose-, and course-dependent inhibition of prenatal amoxicillin exposure on fetal articular cartilage development in fetal mice	10
Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress	10
Cadmium-induced iron dysregulation contributes to functional impairment in brain endothelial cells via the ferroptosis pathway	10
Prognostic biomarker prediction for glioma induced by heavy metals and their mixtures: An in-silico study	10
The effects of UGT1A4 and ABCB1 polymorphisms on clozapine and N- desmethyl clozapine plasma levels in Turkish schizophrenia patients	10
Afzelechin alleviates deltamethrin induced hepatic dysfunction via regulating TLR4/MyD88, HMGB1/RAGE and NF-κB pathway	10
Corrigendum to “Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis” [Toxicology and applied Pharm	10
Lupeol, an androgen receptor inhibitor, enhances the chemosensitivity of prostate cancer stem cells to antiandrogen enzalutamide-based therapy	10
Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis	10
Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro	10
Simvastatin attenuates acute lung injury by activation of A2B adenosine receptor	10
SLC11A1 promotes kidney renal clear cell carcinoma (KIRC) progression by remodeling the tumor microenvironment	10
T-2 toxin triggers immunotoxic effects in goats by inducing ferroptosis and neutrophil extracellular traps	10
Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventions	10
Safety assessment on CBD-rich hemp extract in sub-chronic cross-sex study with rats	10
Decreasing expression of Prohibitin-2 lowers the oncogenicity of renal cell carcinoma cells by suppressing eIF4E-mediated oncogene translation via MNK inhibition	9
Isonardosinone attenuates osteoclastogenesis and OVX-induced bone loss via the MAPK/NF-κB pathway	9
Corrigendum to “Prasugrel anti-ischemic effect in rats: Modulation of hippocampal SUMO2/3-IкBα/Ubc9 and SIRT-1/miR-22 trajectories” [Toxicol Appl Pharmacol. 2021 Sep 1;426:115635]	9
PBK modelling of topical application and characterisation of the uncertainty of Cmax estimate: A case study approach	9
Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk assessment of epyrifenacil	9
Selective modulation of placental and fetal MDR transporters by chronic in utero exposure to NRTIs in Sprague-Dawley rats: Importance for fetoprotection	9
Corrigendum to “Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic” [Toxicology and applied pharmacology 367 (2019) 62–70]	9
The exosome-circ_0001359 derived from cigarette smoke exposed-prostate stromal cells promotes epithelial cells collagen deposition and primary ciliogenesis	9
The co-regulation of the gut microbiome and host genes might play essential roles in metformin gastrointestinal intolerance	9
Baicalin − 2- ethoxyethyl ester alleviates renal fibrosis by inhibiting PI3K/AKT/NF-κB signaling pathway	9
Bongkrekic acid induced neutrophil extracellular traps via p38, ERK, PAD4, and P2X1-mediated signaling	9
Corrigendum to “D-saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling” [Toxicol	9
Hepatotoxicity of N-nitrosodin-propylamine in larval zebrafish by upregulating the Wnt pathway	9
In vitro and in vivo approaches to assess atherosclerosis following exposure to low-dose mixtures of arsenic and cadmium	9
Effect of plasma exosome lncRNA on isoproterenol hydrochloride-induced cardiotoxicity in rats	9
Gene regulation by morpholines and piperidines in the cardiac embryonic stem cell test	9
Evaluation of dermal toxicity and toxicokinetics of povidone‑iodine in Göttingen minipigs	9
Effect of aripiprazole on neural tube development in early chick embryos	9
Study of Huperzine A derivatives with extended protection against soman intoxication	9
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways	9
Targeting CD166+ lung cancer stem cells: Molecular study using murine dendritic cell vaccine	9
Corrigendum to “Selenium-lentinan inhibits tumor progression by regulating epithelial-mesenchymal transition” [Toxicol Appl Pharmacol 360 (2018) 1–8]	9
Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil	9
Berberine attenuates ECM accumulation and the progression of acute liver failure through inhibition of NLRP3 inflammasome signalling	9
WITHDRAWN: Construction and evaluation of risk prediction model for kidney injury in patients treated with PD-1 inhibitors	9
Lung developmental is altered after inhalation exposure to various concentrations of calcium arsenate	9
Toxicological and biochemical mechanisms of pesticides in non-targeted biological systems	9
Serum deprivation protein response intervenes in the proliferation, motility, and extracellular matrix production in keloid fibroblasts by blocking the amplification of TGF-β1/SMAD signal cascade via	9
The surfactant Dioctyl Sodium Sulfosuccinate (DOSS) exposure causes adverse effects in embryos and adults of zebrafish (Danio rerio)	8
Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis	8
Safranal inhibits NLRP3 inflammasome activation by preventing ASC oligomerization	8
The role of MEG3 in the proliferation of palatal mesenchymal cells is related to the TGFβ/Smad pathway in TCDD inducing cleft palate	8
Cardiopulmonary effects of phosphine poisoning: A preliminary evaluation of milrinone	8
A novel halogenated adenosine analog 5’-BrDA displays potent toxicity against colon cancer cells in vivo and in vitro	8
Trans-resveratrol imparts disparate effects on transcription of DNA damage sensing/repair pathway genes in euglycemic and hyperglycemic rat testis	8
GP-14 protects against severe hypoxia-induced neuronal injury through the AKT and ERK pathways and its induced transcriptome profiling alteration	8