Turkish Journal of Pediatrics

Article	Citations
Vaccine refusal risk factors among parents of children with autism spectrum disorders	23
A case of neonatal gastric teratoma complicated with occult gastrointestinal hemorrhage misdiagnosed as lymphangioma	18
The relationship between microRNA-155-5p and postoperative inflammatory markers in children with acute suppurative appendicitis and its role in predicting postoperative complications	15
DNA damage in children with β-thalassemia minor: genotoxicity assessment by comet assay	12
Cockayne syndrome type: a very rare association with hemorrhagic stroke	10
Three locally invasive infantile fibrosarcoma cases treated with larotrectinib	10
The association of meatal stenosis and infant circumcision	10
Brown Vialetto Van Laere syndrome: presenting with left ventricular non-compaction and mimicking mitochondrial disorders	10
Evaluation of the relationship between neonatal serum asprosin levels and anthropometric measurements in newborns of mothers with and without gestational diabetes mellitus	10
Matrix metalloproteinase-7 and matrix metalloproteinase-9 expression is upregulated in congenital lung malformations	10
Pattern of hereditary renal tubular disorders in Egyptian children	8
Sertoli-Leydig cell tumor, thyroid follicular carcinoma and rhabdomyosarcoma of the uterine cervix in a prepubertal girl with pathogenic germline variant in DICER1 gene	8
Evaluation of serum/salivary levels of carnosine and cotinine in recurrent wheezing of young children with passive smoking	8
The efficacy of oral motor interventions on feeding outcomes in newborns with hypoxic-ischemic encephalopathy who received therapeutic hypothermia	7
Congenital heart defects and postoperative follow-up of patients with Williams syndrome as a single center experience and review of the cases from Türkiye	7
DOCK8 deficiency with hypereosinophilia and the syndrome of inappropriate antidiuretic hormone secretion during herpes infection	7
The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19	7
A novel homozygous mutation in the USP53 gene as the cause of benign recurrent intrahepatic cholestasis in children: a case report	6
Safety and efficacy of COVID-19 vaccines in children and adolescents with cancer	6
Cardiac arrest due to a fatal dose of propranolol successfully treated with intravenous lipid infusion	6
Comparison of serum anti-neuronal antibody levels in patients having autism spectrum disorder with and without regression	6
Choice and switch of biologic drugs in juvenile idiopathic arthritis	6
Evaluation of toll-like receptors 2 and 4 polymorphism and intestinal microbiota in children with food allergies	6
Neonatal diabetes mellitus due to a new KCNJ11 mutation - 10 years of the patient`s follow-up	6
Diphallia: a case report of a rare anomaly evaluated by magnetic resonance imaging	6

Cholecystectomy in children: indications, clinical, laboratory and histopathological findings and cost analysis	6
Glomerulonephritis with crescents in childhood; etiologies and significance of M2 macrophages	6
Developmental evaluation in children experiencing febrile convulsions	6
Is there a relationship between joint hypermobility and gastrointestinal disorders in children?	6
Primitive neuroectodermal tumor in a child with Currarino syndrome	5
Short and long term side effect of colistin treatment in preterm infants	5
Response to `SARS-CoV-2 related encephalitis requires documentation of the virus in the cerebrospinal fluid`	5
Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newborns	5
Cost and length of hospital stay for healthcare facilityonset Clostridioides Difficile infection in pediatric wards: a prospective cohort analysis	5
Expression of MicroRNA 146a, 155, 181 and 223 in febrile seizure	5
Short-term outcomes of extremely low birth weight infants in a tertiary neonatal intensive care unit in Türkiye	5
The effect of granulocyte colony stimulating factor on genotoxicity in allogeneic peripheral blood stem cell transplantation donors: a prospective case-control study	5
Can peripheral blood monocyte percentage and lymphocyte monocyte ratio at diagnosis predict survival in pediatric neuroblastoma patients?	5
Imaging spectrum of extracorporeal membrane oxygenation related neurologic events in children	5
Correlation between anthropometric measurements of height and arm span in Indonesian children aged 7-12 years: a cross-sectional study	5
Developmental parameters and physical fitness in preschool children with Minor Neurological Dysfunction	4
Autoimmune/autoinflammatory syndrome induced by adjuvants after multi-component meningococcal serogroup B vaccination in a 7-year-old girl: a case report	4
Spinal muscular atrophy with respiratory distress type 1 (SMARD1): a rare cause of hypotonia, diaphragmatic weakness, and respiratory failure in infants	4
A rare case of juvenile amyotrophic lateral sclerosis	4
A child presenting with bullous emphysema	4
Evaluation of nutritional status and related factors in children with cystic fibrosis	4
A newborn with anaphylaxis due to vancomycin	4
Autism spectrum disorder in patients with inherited metabolic disorders-a large sample from a tertiary center	4
The Türkiye-Syria Earthquake: a response from the editors of the Turkish Journal of Pediatrics	4
Phenotypes of persistent hen`s egg allergy in children and adolescents	4
Intrapancreatic accessory spleen in child	4
The role of self-discontentment and impulsivity for youth smoking behavior, nicotine dependence and future smoking intention in a clinical sample of Turkish adolescents	4
Anxiety among the parents of pediatric patients receiving IVIG therapy during the Covid-19 pandemic	4
Cinacalcet therapy in a child with novel homozygous CASR p.Glu353Lys mutation causing familial hypocalciuric hypercalcemia type 1: case report and review of the literature	4
Bladder granulocytic sarcoma in a child: case report and literature review	4
Hematopoietic stem cell transplantation complicated with EBV associated hemophagocytic lymphohistiocytosis in a patient with DOCK2 deficiency	3
Clinicopathological features and treatment of aggressive natural killer cell leukemia: case series and literature review	3
Enablers and barriers for enteral feeding with mother`s own milk in preterm very low birth weight infants in a tertiary care neonatal intensive care unit	3
Sedation - analgesia - muscle relaxant - withdrawal and delirium practices in pediatric intensive care units in Türkiye	3
Evaluation of retinal nerve fiber layer and choroidal thickness with spectral domain optical coherence tomography in children with sickle cell anemia	3
The role of proangiogenic cytokines in predicting sepsis in febrile neutropenic children with cancer	3
Camptodactyly-arthropathy-coxa vara-pericarditis syndrome and an unusual association with mitral stenosis	3
A case of familial recurrent 17q12 microdeletion syndrome presenting with severe diabetic ketoacidosis	3
Is there a role of viral infection in cystic fibrosis exacerbation in children?	3
Risk factors of disease severity and mechanical ventilation requirement in childhood Guillain-Barré Syndrome	3
The importance of targeted next-generation sequencing based genomic profiling in the diagnosis of childhood acute myeloid leukemia: a single center experience	3
Assessment of vitamin B12 and homocysteine levels in pregnant women admitted for delivery and cord blood samples of their newborn babies: a multicenter study	3
The coexistence of two rare diseases thought to use the same pathologic pathway: cystic fibrosis and Niemann-Pick disease	3
Coats Plus syndrome: a diagnostic and therapeutic challenge in pediatric gastrointestinal hemorrhage	3
Central line-associated bloodstream infection outbreak related to Ralstonia pickettii-contaminated saline in a pediatric hematopoietic stem cell transplant center	3
Seasonal coronaviruses infections in children: do they always cause mild illness?	3
Evaluation of lead levels in children with chronic constipation	3
Cardiac rhabdomyomas: clinical progression, efficacy and safety of everolimus treatment	3
Comprehensive analysis of genotypic and phenotypic characteristics of biotinidase deficiency patients in the eastern region of Türkiye	3
The earthquake disaster in Türkiye: a perspective on newborn evacuation and an ophthalmological approach	3

The impact of the prolonged COVID-19 pandemic on adolescents with eating disorders: a follow-up study from Türkiye	3
Parental knowledge about familial Mediterranean fever: a cross-sectional study	3
Cardiac failure in a child with tuberculous meningitis as a complication of Paroxysmal sympathetic hyperactivity	3
The Health-Related Quality of Life scores and joint health in children and young adults with hemophilia	3
Comparison of ocular posterior segment parameters in the pediatric population with migraine without aura and tension-type headache	3
Multipotent mesenchymal stromal cell therapy for a neonate with congenital diaphragmatic hernia and adhesive small bowel obstruction	3
Interpretation of pseudothrombocytopenia using platelet histograms and flags in a hematology autoanalyzer in a healthy child: a case report	3
Sirolimus treatment of a PTEN hamartoma tumor syndrome presenting with melena	3
Does bile reflux reduce Helicobacter pylori gastritis?	3
A rare association of osteogenesis imperfecta and juvenile idiopathic arthritis: case reports and literature review	3
Common complications in spinal muscular atrophy (SMA) type 1 after nusinersen treatment	3
Cancer and constitutional Mismatch Repair Deficiency syndrome due to homozygous MSH 6 mutation in children with Café au Lait Spots and review of literature	3
Changes in skin barrier integrity by electrical impedance spectroscopy during dupilumab treatment on a child with severe atopic dermatitis	3
Primary renal aspergillosis in a newborn: a case report and review of the literature on children	3
Evaluation of functional gastrointestinal disorders in children aged 4-10 years with autism spectrum disorder	3
A case of crescentic glomerulonephritis with exacerbation of pre-existing IgA nephropathy after COVID-19	3
Non-syndromic perspective on a unique progressive familial intrahepatic cholestasis variant: <i>ZFYVE19 </i>mutation	3
The importance of transient hypothyroxinemia of prematurity and its controversial management	3
Rehospitalization indications of children hospitalized for COVID-19 infections after discharge: Should we suspect long COVID?	3
Rhinovirus as a rare cause of acute onset dilated cardiomyopathy due to myocarditis in a newborn: case report and review of the literature	3
The effects of measures taken during the COVID-19 pandemic on the seasonal dynamics of respiratory viruses in children	3
Pedipacks in the transfusion of pediatric patients to reduce wastage of blood components: an observational study from a tertiary center	3
Whole exome sequencing identifies a novel variant in ABCA3 in an individual with fatal congenital surfactant protein deficiency	2
Has the COVID-19 pandemic negatively impacted children’s development? An assessment of the neurodevelopment of premature babies born during the pandemic	2
Endoscopic treatment of periampullary duodenal duplication cyts in an 18-month-old girl	2
Iron deficiency is not always innocent in childhood: a rare diagnosis of collagenous gastritis	2
A very rare case of a newborn with tetrasomy 9p and literature review	2
Identifying the effects of excess weight, metabolic syndrome and insulin resistance on liver stiffness using ultrasound elastography in children	2
Meningococcemia in a vaccinated child receiving eculizumab and review of the literature	2
Evaluation of ischemia-modified albumin in the diagnosis and the clinical severity of COVID-19 in children	2
Dent’s disease: case series from a single center	2
Evaluation of ciliary functions and ciliary beat frequency via cell culture method in patients with primary ciliary dyskinesia	2
Interaction of functional gastrointestinal disorders with postpartum conditions related to mother and baby	2
The expectant management of a rare neonatal disease: transient neonatal myasthenia gravis	2
Severe myxedema coma and pericardial effusion in a child with Down syndrome: the importance of adherence to levothyroxine therapy	2
Urinary C-peptide creatinine ratio is a significant indicator of non-alcoholic fatty liver disease in children with obesity	2
Inflammatory myofibroblastic tumors in children: clinical characteristics and treatment outcomes with a focus on targeted therapies	2
The first case of combined oxidative phosphorylation deficiency-1 due to a GFM1 mutation in the Serbian population: a case report and literature review	2
Episcleral Iodine-125 radioactive plaque brachytherapy as a salvage treatment for retinoblastoma in the era of intraarterial chemotherapy	2
Response to “Lipid emulsion resuscitation for intractable calcium channel blocker toxicity in pediatric patients”	2
Aspirin-induced hepatotoxicity and anemia in children with acute rheumatic fever	2
Radiotherapy for pediatric non-rhabdomyosarcoma soft tissue sarcomas: a comprehensive review	2
Response to `High-flow nasal cannula failure in Pediatric Emergency Department: Remarks and questions to explore the predictive factors`	2
Non-ocular risk factors in Turkish children with strabismus and amblyopia	2
Correlation and prediction of arterial partial pressure of carbon dioxide from venous umbilical blood gases	2
Expanding the phenotype of DYNC1H1-associated diseases with a rare variant resulting in spinal muscular atrophy with lower extremity predominance (SMA-LED) and upper motor neuron signs	2
Clinical characteristics of firearm-related injuries in children in Turkey	2
Severe acute kidney injury induced by crescentic glomerulonephritis in a child with infective endocarditis	2
Comparison of miRNA expression in patients with seasonal and perennial allergic rhinitis and non-atopic asthma	2
A feasibility study of risk prediction modelling for vasoocclusive crisis in children with sickle cell disease	2
Can early hyperglycemia affect the morbidity/mortality of very low birth weight premature infants?	2
Childhood borderline lepromatous leprosy: a case report	2
Celiac disease and catatonia: more than a coincidence?	2
A rare case of antileucine-rich glioma-inactivated 1 encephalitis in a 14-year-old girl	2
Facial colliculus syndrome due to a Herpes simplex virus infection following Herpes labialis	2
Extremely rare cause of hyperkalemia: ileostomy‒induced hyperkalemia in extremely low birth weight infants	2
The challenge to prove a rare cause of secondary arterial hypertension. A case report of a pediatric renal solitary fibrous tumor	2
Subtle myocardial effects of rheumatic heart disease in children are revealed earlier with two-dimensional speckle tracking echocardiography	2
Relationship between tumor viability during treatment and the clinical outcomes of patients with bladder/prostate rhabdomyosarcoma: a single-center experience	2
Fatal thrombotic microangiopathy in an infant with COVID-19: a case report	2
Evaluation of thymic dimensions in patients with multisystem inflammatory syndrome	2
Identification of candidate genes in a family with cancer overload by whole-exome sequencing	2
Complicated acute appendicitis in children: the importance of stewarding antibiotic prescriptions	2
A histopathological view at the long-term effects of COVID-19 on the gastrointestinal system in children: a single center experience	2
Evaluation of patients diagnosed with phenylketonuria and biotinidase deficiency by the newborn screening program: a ten-year retrospective study	2
Evaluation of risk factors, functionalities, and quality of life in patients with pediatric acute arterial ischemic stroke	2
Infantile tremor syndrome secondary to peroral vitamin B12 replacement therapy: a report of two cases with myoclonus	2
Evaluation of the predictability of clinical and radiological findings in the diagnosis of malrotation	2
Assesment of obesogenic factors in school-age children	2
A rare entity in a pediatric patient: coexistence of emphysematous cystitis and emphysematous pyelonephritis	2
Early-auditory intervention in children with hearing loss and neurodevelopmental outcomes: cognitive, motor and language development	2
Elevated neurotensin levels among obese adolescents may be related to emotion dysregulation and impulsivity: a cross-sectional, case-control study	2
A fatal interstitial lung disease in an anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody negative patient with juvenile dermatomyositis	2
The treatment journey of children with moderate to severe atopic dermatitis in Türkiye: unmet needs	2
Comparison of pediatric antibiotic prescribing practice between low and high prescribers for children in primary care	2
Surface triggering receptor expressed on myeloid cells-1 (sTREM1) in critically ill children: a prospective observational controlled study	1
Relationship between placental autophagy and inflammasome activities with morbidity of extremely preterm infants	1
Evaluation of hair structural abnormalities in children with different neurological diseases	1
Quality of life and the psychological status of the adolescents with asthma and their parents during the COVID-19 pandemic	1
Clinical and demographic characteristics of childhood neuro-ophthalmology diseases at a tertiary eye care center	1

Isolated hypogonadotropic hypogonadism in adolescence: Do we need to measure the pituitary, stalk or other imaging markers? A retrospective magnetic resonance imaging study	1
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center	1
Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown cause	1
Prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injury	1
Saccharomyces cerevisiae fungemia due to an unexpected source in the pediatric intensive care unit	1
The effect of breast milk nesfatin-1 and ghrelin levels on growth in infants with SGA	1
The causes of parental vaccine refusal: results of a survey from Giresun, Turkey	1
Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study	1
Comparison of prematurity-related outcomes and complications in very low birth weight (VLBW) neonates fed with mother’s own milk versus donor milk: a comparative study	1
Significance of intestinal alkaline phosphatase in predicting histological activity of pediatric inflammatory bowel disease	1
Impact of endocrine disorders associated with cleft lip and palate	1
Persistent moderate methylmalonic aciduria in a patient with methylmalonyl CoA epimerase deficiency	1
IgE mediated food allergy in Turkey: different spectrum, similar outcome	1
A child with intravascular fasciitis mimicking deep vein thrombosis: a case report	1
Rhombencephalitis and longitudinal extensive myelitis associated with dinutuximab use in high-risk neuroblastoma	1
Nutritional rickets in Turkish and refugee children aged 0-2: an increasing problem despite vitamin D prophylaxis	1
The role of culture on parenting boys as a potential risk factor in the development of male eating disorders during adolescence in Turkey	1
A rare case of Klippel-Trenaunay syndrome presenting with chronic myeloid leukemia	1
Spontaneous hyphema in juvenile idiopathic arthritis uveitis	1
Cost-saving approach with screening of selected variants in genetic diagnosis in Turkish pediatric familial Mediterranean fever patients: a single center longitudinal study	1
Autosomal recessive hypophosphatemic rickets type 2; a novel mutation in the ENPP1 gene	1
Healthcare workers` knowledge level regarding anaphylaxis and usage of epinephrine auto-injectors	1
Clinical and radiologic manifestations of Mycoplasma pneumoniae infection in children	1
The relationship between immature platelet fraction and severity of acute bronchiolitis	1
Lethal encephalitis in a pediatric patient with SARS-CoV-2	1
The role of red blood cell distribution width (RDW) in the diagnosis of pediatric sepsis	1
Pre- and postoperative levels of serum brain-derived neurotrophic factor in neonates with congenital heart defects	1
Implications of serial magnetic resonance imaging in the management of a newborn with vein of Galen aneurysmal malformation and a review of the relevant literature	1
Clinicoepidemiological findings of childhood brucellosis in a tertiary care center in Central Anatolia: with the emphasis of hematological findings	1
Treatment of systemic juvenile idiopathic arthritis: conventional treatment versus biologics	1
Development of preschool refugee children living under temporary protection status	1
Pediatricians` attitudes, practices, and perceived barriers to school readiness	1
The effect of treatment with melatonin on primary school aged children with difficulty in initiation and maintenance of sleep	1
Epileptic encephalopathy with electrical status epilepticus during slow sleep: evaluation of treatment response from a tertiary center	1
The role of plasma exchange in acute liver failure of autoimmune etiology	1
Could plasma based therapies still be considered in selected cases with atypical hemolytic uremic syndrome?	1
The effectiveness of the ketogenic diet in drug-resistant childhood epilepsy	1
The relationship between lung function, exercise capacity, oxidant and antioxidant response in primary ciliary dyskinesia and cystic fibrosis	1
Catastrophic antiphospholipid syndrome accompanied by complement regulatory gene mutation	1
Differences in physical activity, sedentary time, and anthropometric variables among children and adolescents: The TUBON project	1
Attitudes of parents with children aged 12-18 to COVID-19 vaccines for themselves and their children	1
Cerebral sinovenous thrombosis in children: clinical presentation, locations, and acquired and inherited prothrombotic risk factors	1
Cerebral developmental venous anomalies in children with mismatch repair deficiency	1
The outcome of functional constipation in Saudi children	1
Concurrent pyoderma gangrenosum and Takayasu arteritis in an infant: diagnostic challenges and treatment considerations	1
The effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases: objectives and design of a randomized controlled trial	1
Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity	1
Treatment results of modified BFM protocol in pediatric high-risk Burkitt lymphoma	1
Compound heterozygous mutations in the helicase RTEL1 causing Hoyeraal-Hreidarsson syndrome with Blake`s pouch cyst: a case report	1
Twelve years of experience in the treatment of newborns with intrauterine gastrointestinal perforation	1
Timeliness of postnatal surgery in newborns with open neural tube defects: a single center experience	1
Determining the effect of time dependent and time independent factors on pneumonia of children under five in North west Ethiopia	1
Phenotypic and genotypic characteristics of children with Bartter syndrome	1
Clinically important intracranial abnormalities in children presenting with first focal seizure	1
Massive true thymic hyperplasia in a 3-month-old infant: case report and literature review	1
Prenatal diagnosis of congenital megalourethra: case report and literature review	1
Tracking postural stability of children and adolescents after a concussion: sport-related versus non-sport-related concussion	1
Gastroenteropancreatic neuroendocrine tumors in children and adolescents	1
A rare complication of IgA vasculitis: renal and intestinal ischemia successfully treated with plasmapheresis	1
Decreased antioxidant capacity with serum native thiol and total thiol levels in children with hemophilia A: a prospective case-control study	1
Clinical characteristics, late effects and outcomes in pineoblastomas in children: a single center experience	1
Should we give priority to plasma exchange and hyperbaric oxygen treatment before deciding on amputation for severe crush injuries?	1
Chronic inflammatory demyelinating polyradiculoneuropathy associated with Sjögren`s syndrome in a child	1
Clinical and molecular findings in 6 Turkish cases with Krabbe disease	1
What has changed in the last 25 years in osteosarcoma treatment? A single center experience	1
Trend in initial presenting features of type 1 diabetes mellitus over a 24 year period in Turkey: a retrospective analysis of 814 cases	1
Maternal phthalate exposure during pregnancy and male reproductive disorders: a systematic review and metaanalysis	1
Recovery of cyanosis after esophageal intubation in a neonate with tracheal agenesis: a case report	1
Clinical follow-up of children with high vitamin B12 values: should we worry?	1
Microbiological characteristics and outcomes of children with pleural empyema admitted to a tertiary hospital in southeast China, 2009-2018	1
Management of pediatric hemolytic uremic syndrome	1
Response to `Attitudes of parents with children aged 12-18 to COVID-19 vaccines for themselves and their children: vaccine hesitancy in Türkiye`	1
Pulmonary involvement in children with Langerhans cell histiocytosis	1
Priapism associated with COVID-19: a pediatric case	1
Foreign body aspiration through the eyes of a pediatric pulmonologist: Is it possible to reduce the rate of negative rigid bronchoscopies?	1
Response to “Rehospitalization indications of children hospitalized for COVID-19 infections and long COVID”	1
Pneumatosis intestinalis: Does it always indicate necrotizing enterocolitis?	1
Common viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter study from Türkiye	1
Pregabalin abuse in adolescence: a case series	1
The effect of the COVID-19 pandemic on long-term treatment compliance and disease control in children with persistent asthma	1
Imaging manifestations of neonatal necrotizing enterocolitis to predict timing of surgery	1
Comparison between oral melatonin and 24% sucrose for pain management during retinopathy of prematurity screening: a randomized controlled trial	1
Rare presentation of levamisole-induced leukoencephalopathy in a pediatric patient: seizure	1
Computed tomography with clinical scoring to differentiate phytobezoar from feces in childhood small bowel obstruction	1
The risk factors for food allergy in infants with atopic dermatitis	1
The predictive role of lung clearance index on FEV<sub>1</sub> decline in cystic fibrosis	1
Comparison of mothers of adolescents diagnosed with type 1 diabetes mellitus and mothers of healthy adolescents in terms of difficulty in emotion regulation, depression and anxiety levels and clinical	1
The functional health status of children with cerebral palsy during the COVID-19 pandemic stay-at-home period: a parental perspective	1
Assessment of the changing trends in maternal knowledge about management of fever and antibiotic use in the last decade in Türkiye	1
COVID-19-related anxiety in phenylketonuria patients	1
A unique case of a newborn with a hemangioma on the omphalocele sac	1
Determination of thiol-disulphide homeostasis in premenstrual syndrome during adolescence	1
Tuberculosis risk in the biologic era: tuberculin skin test conversion rates in children with rheumatologic diseases	1
Efficacy of single dose of phenytoin/fosphenytoin in benign convulsions with mild gastroenteritis	1
Evaluation of the relationship between cardiopulmonary exercise test findings and clinical status in children and adolescents with congenital heart disease	1