OOIR: Observatory of International Research

Papers

(The H4-Index of Bioorganic Chemistry is 50. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Effect of lathyrane-type diterpenoids in neural stem cell physiology: Microbial transformations, molecular docking and dynamics studies	250
New N-Alkylketonetetrahydroisoquinoline derivatives exhibits antitumor effect by HA-CD44 interaction inhibition in MDA-MB-231 breast cancer	168
The first attempt in synthesis, identification, and evaluation of SEPT9 inhibitors on human oral squamous carcinomas	106
Synthesis and biological evaluation of 4-((3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)quinoline derivatives as novel potential transforming growth factor-β type 1 receptor inhibitors for hepatoc	94
Design, synthesis, crystal structure, fungicidal activity, and mechanism of action of novel thiazole-based hydrazide derivatives containing the 4-aminoquinazoline moiety	93
Design, synthesis, and biological evaluation of novel FGFR1 PROTACs	89
Exploration of triazole derivatives, SAR profiles, and clinical pipeline against Mycobacterium tuberculosis	84
Design, synthesis, and biological evaluation of novel thiourea derivatives as small molecule inhibitors for prostate specific membrane antigen	78
Electron-rich anilines as cleavable linkers for peptides	77
Heterologous expression of calcium-independent mesophilic α-amylase from Priestia megaterium: Immobilization on genipin-modified multi-walled carbon nanotubes and silica supports to enhance thermostab	77
Recent advancements in the quest of benzazoles as anti-Mycobacterium tuberculosis agents	75
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis	73
Exploring i-Motif DNA binding with benzothiazolino Coumarins: Synthesis, Screening, and spectroscopic insights	73
Targeting Wnt signaling pathway with small-molecule therapeutics for treating osteoporosis	71
Discovery of highly oxygenated cytochalasans with antiproliferative activity from an endophytic fungus Boeremia exigua	71
Design, synthesis, antimalarial activity, and in-silico studies of new benzimidazole/pyridine hybrids as dihydrofolate reductase inhibitors	70
N-Heterocyclic functionalized chalcone derivatives as anti-inflammatory agents for atopic dermatitis treatment by inhibiting JAK1/STAT3 signaling pathway	70
Development and therapeutic potential of DNA-dependent protein kinase inhibitors	66
20-Deoxyingenol ester and ether derivatives: Synthesis, properties and cytotoxicity	66
Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition	65
Mahanimbine isolated from Murraya koenigii inhibits P-glycoprotein involved in lung cancer chemoresistance	64
Multi-component forms of the 2nd generation H1 receptor antagonist drug, Bilastine and its enhanced physicochemical characteristics	63
Discovery of novel dihydropyrazole-stilbene derivatives for ameliorating heart failure through modulation of p38/NF-κB signaling pathway	63
Discovery of quorum sensing inhibitors against Pseudomonas aeruginosa from Aspergillus sp. NB12	62
SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells	61

Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects	59
One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico	58
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis	57
Topoisomerase II inhibitors design: Early studies and new perspectives	57
Peptide Nucleic Acids: Recent Developments in the Synthesis and Backbone Modifications	57
Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study	56
Lipopeptides production by a newly Halomonas venusta strain: Characterization and biotechnological properties	55
Recent developments of P-glycoprotein inhibitors and its structure–activity relationship (SAR) studies	54
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress	54
Cholinesterase inhibitors assessment of aporphine alkaloids from Annona crassiflora and molecular docking studies	53
Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary s	53
Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents	53
Tetrahydrocarbazoles incorporating 5-arylidene-4-thiazolinones as potential antileukemia and antilymphoma targeting tyrosine kinase and tubulin polymerase enzymes: Design, synthesis, structural, biolo	52
Corrigendum to “Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds” [Bioorg Chem. 151 (2024) 107646]	52
Recent advances in the natural product analogues for the treatment of neurodegenerative diseases	52
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa	52
Synthesis of 3-hydroxy-4-pyridinone hexadentate chelators, and biophysical evaluation of their affinity towards lipid bilayers	52
Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis	52
Identification of sanguinarine as c-MYC transcription inhibitor through enhancing the G-quadruplex-NM23-H2 interactions	52
Issue TOC	51
Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7β substituted steroids	51
Structurally diverse phenylpropanoyl phloroglucinol derivatives from Mallotus philippensis and their anti-bacterial activities	51
Development of an at-line coupling of LC-QTOF-ESI-MS/MS to steroid 5-alpha reductase inhibition assay, a fast bioactive targeting and guided purification of natural complex sample, Impatiens balsamina	51
Synthesis, in vitro anticancer activity and in silico studies of certain isoxazole-based carboxamides, ureates, and hydrazones as potential inhibitors of VEGFR2	50
Antiproliferative activity, enzymatic inhibition and apoptosis-promoting effects of benzoxazole-based hybrids on human breast cancer cells	50