Bioorganic Chemistry

Article	Citations
Editorial Board	171
A chemoenzymatic process for preparation of highly purified dehydroepiandrosterone in high space-time yield	148
Synthesis and biological evaluation of novel naproxen–phenacetin triazole hybrids as promising anti-inflammatory agents with enhanced gastrointestinal tolerability	116
Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhi	101
Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents	86
De novo discovery and preclinical evaluation of a novel peptide radiotracer for PET imaging of TROP-2 in non-small cell lung cancer	85
THP as a sensor for the electrochemical detection of H2O2	85
Repurposing tavaborole to combat resistant bacterial infections through competitive inhibition of KPC-2 and metabolic disruption	83
Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents	80
Synergistic engineering of Nattokinase terminal and calcium-binding regions for enhanced catalytic performance and Oral stability	80
Discoidin domain receptor inhibitors as anticancer agents: A systematic review on recent development of DDRs inhibitors, their resistance and structure activity relationship	77
Design, synthesis, biological evaluation and docking study of some new aryl and heteroaryl thiomannosides as FimH antagonists	75
Design and synthesis of novel quinoline-chalcone derivatives as dual inhibitors of tubulin polymerization and P-glycoprotein to overcome cisplatin resistance in cervical cancer	74
Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis	70
Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors	70
Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates	67
Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure	65
Structure-based optimization of TEAD inhibitors: Exploring a novel subpocket near Glu347 for the treatment of NF2-mutant cancer	63
Rational design of new quinoline-benzimidazole scaffold bearing piperazine acetamide derivatives as antidiabetic agents	62
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation	62
Diversified applications and research progress of plant-derived natural products in PROTAC technology	61
Engineering an (R)-selective transaminase for asymmetric synthesis of (R)-3-aminobutanol	60
Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb.	59
Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis	57
Strategies on boosting photothermal conversion efficiency of organic molecules for photothermal therapy	57

Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway	55
Corrigendum to “Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds” [Bioorg Chem. 151 (2024) 107646]	55
Synthesis and in vitro leishmanicidal activity of novel N-arylspermidine derivatives	53
Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)	53
Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: Biological activity and structural activity relationship	52
Design, synthesis, and biological evaluation of novel FGFR1 PROTACs	50
Ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth(III)triflate catalyzed synthesis and antioxidant activity	48
2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat	48
Discovery of oleanolic acid derivatives that inhibit tau protein phosphorylation and neuroinflammation induced by Aβ25–35 in vitro and in vivo	48
Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility	47
Novel dual-channel ratiometric fluorescence probe for SO2 detection in food and bioimaging applications based on FRET mechanism	46
Rational design of novel procaspase-3 activators for the targeted therapy of triple-negative breast cancer	46
Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage	46
Casuattimines A–N, fourteen new Lycopodium alkaloids from Lycopodiastrum casuarinoides with Cav3.1 channel inhibitory activity	45
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa	45
Structurally diverse phenylpropanoyl phloroglucinol derivatives from Mallotus philippensis and their anti-bacterial activities	45
Raphasemenate A-J: Ten phenylpropionates with antibacterial activity from Raphani Semen	45
Identification and molecular mechanism of novel 5-alkenyl-2-benzylaminothiazol-4(5H)-one analogs as anti-melanogenic and antioxidant agents	45
Iron chelation and inhibition of metallopeptidases mediate anti-Trichomonas vaginalis activity by a novel 8-hydroxyquinoline derivative	45
seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels	45
Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resi	44
Construction of an AND logic gate fluorescent probe for highly efficient detection of formaldehyde and Pim-1 kinase	44
Synthesis of indomethacin thiadiazole urea derivatives and determination of GSTA4 inhibition and cytotoxic activity against colorectal carcinoma	44
Editorial Board	42
One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico	41
Mn-doped bimetallic synergistic catalysis boosts for enzymatic phosphorylation of N-Acetylglucosamine/ N-Acetylgalactosamine and their derivatives	41
6-C-Linked trehalose glycolipids signal through Mincle and exhibit potent adjuvant activity	41
Dimethyl bisphenolate inhibits glioblastoma growth by promoting cell cycle arrest and apoptosis	41
Rosmarinic acid turned α-syn oligomers into non-toxic species preserving microtubules in Raw 264.7 cells	41
Targeting nuclear receptor-binding SET domain protein 2 (NSD2) for cancer therapy: Challenges and emerging strategies	41
Elucidating the potential of novel class biphenyl-phenyl acetate, IDD-AN-A1, an inhibitor targeting Isocitrate Lyase in Mycobacterium tuberculosis: A target to lead approach	40
Carvacrol/thymol derivatives as highly selective BuChE inhibitors with anti-inflammatory activities: Discovery and bio-evaluation	40
Synthesis and biological evaluation of new nicotinic acid derivatives as potential anti-inflammatory agents with enhanced gastric safety profile	40
Identification and bioactivity evaluation of miliusanes from Miliusa sinensis	39
Rational development of an ESIPT-based fluorescent probe with large Stokes shift for imaging of hydrogen sulfide in live cells	39
Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition	39
Functional characterization and regioselectivity manipulation of two Benzylisoquinoline alkaloids O-methyltransferases from Stephania yunnanensis	39
A simple ratiometric fluorescent probe for two-photon imaging of carbon monoxide in living cells and zebrafish	39
Quinolinyl-appended chalcones as promising antiproliferative and trypanocidal agents: Synthesis, biological profiling, and further transformation into novel benzo[f]pyrazolo[5,1-a][2,7]naphthyridine a	39
Optimized extraction, isolation and identification of bioactive sesquiterpenes from Inula racemosa	39
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis	39
Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers	39
Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy	39
A dual-responsive fluorescent probe for simultaneous detection of H2S and SO2 and its application in an oxidative stress model of neuronal cells	38
Fatty acid chain modification enhances the serum stability of antimicrobial peptide B1 and activities against Staphylococcus aureus and Klebsiella pneumoniae	37
In vitro and in vivo studies on three new 8-hydroxyquinoline-based zinc(II) coordination compounds as potential antimelanoma cancer agents	37
Dihydro-β-agarofuran sesquiterpenoids from the root bark of Tripterygium wilfordii and their anti-neuroinflammatory activities	37
Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal	37
Corrigendum to “Nanogel delivered benzimidazole-triazole hybrids as potent multitarget inhibitors of topoisomerase and tubulin in triple-negative breast cancer” [Bioorg. Chem. 167 (2025) 109288]	37
Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary s	36

Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy	36
Terpenoids from of Euphorbia helioscopia L. with anti-Zika virus activity	36
Dihydroartemisinin suppresses metastatic potential and induces apoptosis in gastric adenocarcinoma: An integrative experimental and computational analysis revealing inhibition of MMP14 and promotion o	35
Renewable resource of sucrose with clusteroluminescence mechanism and applications	35
Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors	35
Development and evaluation of chitosan conjugated Isatin-linked Pyrazole derivative to target anti-inflammatory and anti-fibrotic in ethanol induced liver fibrosis using an in-vivo zebra fish model	35
A newly synthesized magnetic nanoparticle coated with glycidyl methacrylate monomer and 1,2,4-Triazole: Immobilization of α-Amylase from Bacillus licheniformis for more reuse, stability, and activity	35
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis	34
Ultra-fast responses NIR fluorescence chemosensor for monitoring HSO3−/SO2 and viscosity as well as its applications in real food samples and living biosystem	34
Discovery of new 1,2,3,4-tetrahydro-β-carboline derivatives decorated with 3-N-substituted propionyl moiety flexibly bridged-chain as reactive oxygen species inducer for efficient antibacterial treatm	34
Biocatalytic conversion of the natural compound bergamottin into novel bioactive epoxy-derivatives using engineered cytochrome P450 BM3	33
Targeted isolation and antipyretic mechanisms of 5,7,4′-trimethoxyflavone and p-hydroxybenzoic acid from Mimosa pudica root via cell membrane-coated magnetic carbon spheres integrated with thermal shi	33
4-Phenylcoumarin derivatives as new HIV-1 NNRTIs: Design, synthesis, biological activities, and computational studies	32
Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists	32
Peptide inhibitors of angiotensin-I converting enzyme based on angiotensin (1–7) with selectivity for the C-terminal domain	32
Visualization of nonsmall-cell lung cancer by near-infrared fluorescence imaging with tumor-targeting peptide ABT-510	32
Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock	32
Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents	31
Novel deep eutectic solvents promote enzyme-substrate molecular dynamic adaptation to enhance sucrose ester synthesis efficiency	31
New pyrrolo[3,4-d] isoxazolidines hybrid with furan as antitumor agents and multi-target enzyme inhibitors: Synthesis and in silico study	31
Design, synthesis, and biological evaluation of novel amidoxime or amidine analogues of some 4-anilino-6,7-dimethoxyquinazolines with a potent EGFR inhibitory effect	31
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents	31
Issue TOC	31
Drugs repurposing: An approach to identify new hits against anticancer drug target TFIIH subunit p8	31
Novel 2-oxoethylthio-sulfonamide derivatives targeting pyocyanin/staphyloxanthin producing-pathogens: Antibiofilm, DHPS inhibition and gamma radiation effects	31
Inhibitory effect of liriopesides B in combination with gemcitabine on human pancreatic cancer cells	31
Design and development of a bright NIR fluorescent probe for selective HSA detection in human blood serum and urine	30
Targeting the epigenetic reader “BET” as a therapeutic strategy for cancer	30
Artemzhongdianolides A1-A21, antihepatic fibrosis guaiane-type sesquiterpenoid dimers from Artemisia zhongdianensis	30
Discovery of 6-amino pyridine clubbed heterocycles as potent dual GSK-3β/CK-1δ inhibitors for the treatment of Alzheimer's disease	30
15-Hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates hepatic abnormal lipid metabolism, ER stress, and inflammation through PGE2/EP4 in T2DM mice	30
Multimodal profiling of Pepcan-CB1 receptor structure-activity relationships: integrating molecular dynamics simulations, biological profiling, and the deep learning model MuMoPepcan	30
Issue TOC	30
Synthesis and bioevaluation of Scutellarein-Tertramethylpyrazine hybrid molecules for the treatment of ischemic stroke	29
S-Alkylated sulfonium betulin derivatives: Synthesis, antibacterial activities, and wound healing applications	29
Identification of CH2-linker modified desfluoroquinolone-aminopyrimidine hybrids to combat antibiotic-resistant gram-positive bacteria	29
Design, synthesis and biological evaluation of coumarin derivatives as potential BRD4 inhibitors	29
Design, synthesis, and structure–activity relationships of xanthine derivatives as broad-spectrum inhibitors of coronavirus replication	29
Discovery of novel Macrocyclic small molecules Based on 2-Amino-4-thiazolylpyridineas selective EGFR inhibitors with high Blood-Brain barrier penetration for the treatment of glioblastoma	29
Design, synthesis and biological evaluation of new 2,6-difluorinated phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new antimicrotubule agents	29
SMART-guided discovery of Sarpagine-type monoterpene indole alkaloids from Rauvolfia vomitoria and the synergistic effects with cisplatin against human ovarian cancer cells	29
Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking	29
Structural characterization of Typha latifolia polysaccharides and study on their mechanism of action in improving type 1 diabetes in mice	28
Mechanism of ginsenoside AD-1 improving pulmonary fibrosis by regulating the HIF-1α/ HSP/TGF-β1 signaling pathway and mesenchymal transition	28
Issue TOC	28
Design, synthesis and biological evaluation of a novel non-Gemini analog of UVB1 and crystal structure of its complex with the vitamin D receptor	28
CC1007, a small molecular compound, suppresses multiple myeloma via upregulation of Nur77	28
Buckyballs to fight pandemic: Water-soluble fullerene derivatives with pendant carboxylic groups emerge as a new family of promising SARS-CoV-2 inhibitors	28
Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold	28
Tripeptide linked dispiro cyclotriphosphazene conjugates: Synthesis, molecular docking analysis of compounds binding within cancer cell line receptors and in vitro cytotoxic and genotoxic activities	28
The insight into the intermolecular interactions between protamine and insulin lispro	28
Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression	28
Apigenin analogs as α-glucosidase inhibitors: Molecular docking, biochemical, enzyme kinetic, and an in vivo mouse model study	28
Site-selective sulfation of N-glycans by human GlcNAc-6-O-sulfotransferase 1 (CHST2) and chemoenzymatic synthesis of sulfated antibody glycoforms	28
Enantiocomplementary synthesis of β-adrenergic blocker precursors via biocatalytic nitration of phenyl glycidyl ethers	28
Discovery of a novel Coumarin-Dihydroquinoxalone derivative MY-673 as a tubulin polymerization inhibitor capable of inhibiting the ERK pathway with potent anti-gastric cancer activities	28
Discovery of novel cycloalkyl-fused thiazole-based pyrimidine derivatives as highly potent CDK2 inhibitors with promising antitumor activity	28
Synthesis of 2-chloropurine ribosides with chiral amino acid amides at C6 and their evaluation as A1 adenosine receptor agonists	28
Targeted discovery of diterpene compounds ostamycins with anti-influenza a viral activity from a deepsea-derived Streptomyces strain	28
Sesquiterpene lactones from Elephantopus scaber exhibit cytotoxic effects on glioma cells by targeting GSTP1	28
Synthesis and biological evaluation of novel isatin-phenol hybrids as potential antitumor agents	28
Gold nanoparticles-based targeted delivery of rapamycin and Olaparib to breast cancer: An in vitro and in vivo approach	28
Discovery of tetrasubstituted tetrahydropyrimidines as novel inhibitors against influenza a virus	27
Synthesis and evaluation of pentacyclic triterpenoids conjugates as novel HBV entry inhibitors targeting NTCP receptor	27
Identification of novel 3-aryl-1-aminoisoquinolines-based KRASG12C inhibitors: Rational drug design and expedient construction by C H functionalization/annulation	27
Sustainable synthesis of ZnO and FexOy nanoparticles and their nanocomposite ZnFe2O4: Comprehensive characterization and applications in antioxidant activity and antibiotics degradation efficiency	27
Developing a golgi-targeted fluorescent probe for in situ visualization of the dynamic changes of H2S in cellular stress	27
Aurora kinases, emerging critical targets for cancer treatment and related new therapeutic strategies	27
Design and synthesis of novel 2-S-alkylated Quinazolinones as dual BRAFV600E and EGFR inhibitors in melanoma: Mechanistic insights from apoptosis and cell cycle modulation	27
Unveiling the potential of novel natural product-based MTDLs that integrate cinnamamide scaffold as multifunctional agents for the treatment of Alzheimer's disease	27
Discovery of antitubercular potential of trans-3-indoleacrylic acid and its derivatives targeting Mycobacterium tuberculosis: A combined in vitro and in silico investigation	27
Therapeutic applications and molecular mechanisms of TNIK inhibitors: A comprehensive review of current advances	27
Metabolism of natural and synthetic bioactive compounds in Cunninghamella fungi and their applications in drug discovery	27
Ugi reaction-assisted assembly of covalent PROTACs against glutathione peroxidase 4	27
Bioactive Dioxo-Phosphobetaines derived from the reaction of Dichlorodinitrobenzofuroxane with various phosphines	27
Heteroatom-modified chlorins in photodynamic therapy: phosphorus- and sulfur-containing strategies to enhance targeting and selectivity	26
A bifunctional naphthalimide-based fluorescent probe for imaging lysosomal peroxynitrite and viscosity in living cells and zebrafish	26
Design and evaluation of DNA aptamers with “stem-loop-chain” structures for spectrum neutralization of ricin and abrin	26
Design, Synthesis, Biocompatibility, molecular docking and molecular dynamics studies of novel Benzo[b]thiophene-2-carbaldehyde derivatives targeting human IgM Fc Domains	26
Multi-targeting oligopyridiniums: Rational design for biofilm dispersion and bacterial persister eradication	26

4-Anilinoquinazoline carbamate derivatization as a platform for prodrug design and localized drug delivery	26
Editorial Board	26
Multifunctional porphyrin-substituted phenylalanine–phenylalanine nanoparticles for diagnostic and therapeutic applications in Alzheimer’s disease	26
Hydantoin based dual inhibitors of ALR2 and PARP-1: Design, synthesis, in-vitro and in-vivo evaluation	26
Dual site reactivity of indole-3-Schiff bases with S/Se/Cl substituted ketenes for stereoselective C-4 substituted indole-β-lactams, biological evaluations, magic chloro effect and molecular docking s	26
Isatin-pyrimidine hybrid derivatives as enoyl acyl carrier protein reductase (InhA) inhibitors against Mycobacterium tuberculosis	26
A novel arylnaphthalene lignan analogue targets CYP51 to inhibit Cryptococcus neoformans growth	26
Site-directed double monoubiquitination of the repeat domain of the amyloid-forming protein tau impairs self-assembly and coacervation	26
Novel Hsp90 inhibitors as leads for the development of radiotheragnostics for Meitner-Auger electron therapy	26
Marine natural products with anti-MRSA activities: promising candidates for antibacterial drug discovery	25
In vitro α-amylase and α-glucosidase inhibition study of dihydropyrimidinones synthesized via one-pot Biginelli reaction in the presence of a green catalyst	25
RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies	25
Ginsenoside Rh4 inhibits breast cancer growth through targeting histone deacetylase 2 to regulate immune microenvironment and apoptosis	25
Combined PET and near-infrared fluorescence probe based on lapatinib targeting HER2 for in vivo tumor imaging	25
PD0325901, an ERK inhibitor, attenuates RANKL‐induced osteoclast formation and mitigates cartilage inflammation by inhibiting the NF-κB and MAPK pathways	25
Design, synthesis, and anti-hepatocellular carcinoma activity evaluation of aryl Lenvatinib derivatives: Exploring potential VEGFR-2 inhibitors	25
Pleiotropically activation of azaphilone biosynthesis by overexpressing a pathway-specific transcription factor in marine-derived Aspergillus terreus RA2905	25
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy	25
Targeting FUT1-mediated EGFR fucosylation and COX-2 reverses gemcitabine resistance by activating immunogenic cell death in hepatocellular carcinoma	25
Volatile oils of Schisandra chinensis (Turcz.) Baill alleviates Parkinson's disease by activating the Nrf2 pathway to positively regulate autophagy and oxidative stress	25
Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors	25
Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics	25
Adenine nucleotides as potent and selective GPR17 modulators	25
Peniandrastins A–H: Andrastin-type meroterpenoids with immunosuppressive activity from a Penicillium sp.	25
Oxidized tea polyphenol (OTP-3) targets EGFR synergistic nimotuzumab at inhibition of non-small cell lung tumor growth	25
New glycoconjugation strategies for Ruthenium(II) arene complexes via phosphane ligands and assessment of their antiproliferative activity	25
Discovery of evodiamine derivatives as potential lead antifungal agents for the treatment of superficial fungal infections	25
TRK inhibitors in cancer therapeutics: Recent advances and future perspectives	25
Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents	25
Design, synthesis, molecular docking and molecular dynamics studies of novel triazolothiadiazine derivatives containing furan or thiophene rings as anticancer agents	25
Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process	25
Molecular glues targeting GSPT1 in cancers: A potent therapy	25
Discovered cassane diterpenoids from Caesalpinia mimosoides lam. Exhibited anti-renal fibrosis activity via regulating TGF-β1/Smads signaling pathway	24
Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma	24
Development of novel cyanopyridines as PIM-1 kinase inhibitors with potent anti-prostate cancer activity: Synthesis, biological evaluation, nanoparticles formulation and molecular dynamics simulation	24
7S,15R-Stereoisomer of phenylethylamino derivative of colchicine exhibits potent in-vitro and in-vivo anti-cancer activity against prostate Cancer: Assessing the impact of stereochemistry on biologica	24
Identification of isatin-triazole-benzenesulfonamide hybrids as dual hCA IX/XII and c-met inhibitors with hypoxia-mediated chemo-sensitizing activity	24
Synthesis and preclinical evaluation of a novel probe [18F]AlF-NOTA-IPB-GPC3P for PET imaging of GPC3 positive tumor	24
Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors	24
Evolution of peptide YY analogs for the management of type 2 diabetes and obesity	24
A multi-route chemiluminescent probe for real-time imaging of β-amyloid pathology in Alzheimer's disease	24
Design, synthesis and evaluation of quinolone quaternary ammonium antibacterial agent with killing ability to biofilm	24
Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa	24
Ac34FGlcNAz is an effective metabolic chemical reporter for O-GlcNAcylated proteins with decreased S-glyco-modification	24
Synthesis, molecular docking and biological evaluation of 1,2,4-oxadiazole based novel non-steroidal derivatives against prostate cancer	24
Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review	23
Design, synthesis, in vitro, and in silico enzymatic evaluations of thieno[2,3-b]quinoline-hydrazones as novel inhibitors for α-glucosidase	23
Editorial Board	23
Discovery of indoline-based derivatives as effective ROCK2 inhibitors for the potential new treatment of idiopathic pulmonary fibrosis	23
(±)-Heterocageflavone, anti-inflammatory isoprenylated flavonoids with a tricyclo[5.3.1.03,8]undecane moiety from Artocarpus heterophyllus	23
Functionalized magnetic particles coupled with LC-MS strategy facilitated discovery of trace thioalkaloids with potent immunosuppressive activity	23
Curcumol derivatives exhibit ameliorating effects on lipopolysaccharide-induced acute lung injury: Synthesis, biological evaluation, structure–activity relationship and action mechanism	23
6-acrylic phenethyl ester-2-pyranone derivative induces apoptosis and G2/M arrest by targeting GRP94 in colorectal cancer	23
Editorial Board	23
Recent advances and future perspectives of noncompetitive proteasome inhibitors	23
Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma	23
The first peptide derivatives of dioxybiphenyl-bridged spiro cyclotriphosphazenes: In vitro cytotoxicity activities and DNA damage studies	23
Issue TOC	23
Editorial Board	23
Acquiring stereospecific new pseudosugars: Obtaining rac-decahydro-1,4-epoxynaphthalene-2,3,5,6,7,8-hexaols from the Diels-Alder reaction and investigating their biological effects	23
Green synthesis and anti-tumor efficacy via inducing pyroptosis of novel 1H-benzo[e]indole-2(3H)-one spirocyclic derivatives	23
Benzoxazole-appended piperidine derivatives as novel anticancer candidates against breast cancer	22
1H NMR-guided isolation of hasubanan alkaloids from the alkaloidal extract of Stephania longa	22
Protein coupled thionine acetate probed silica nanoparticles: An integrated laser-assisted therapeutic approach for treating cancer	22
Identification of new multi-substituted 1H-pyrazolo[3,4-c]pyridin-7(6H)-ones as soluble guanylyl cyclase (sGC) stimulators with vasoprotective and anti-inflammatory activities	22
Breast cancer cell targeted Pt(II) complexes: their bio-physical interaction and molecular docking with bio-receptors & HER2 cancer protein	22
New anti-inflammatory and non-cytotoxic metabolites of methylstenbolone obtained by microbial transformation	22
Efficient synthesis, stability-guided optimization and anticancer evaluation of bee venom peptide Melittin	22
Discovery of baicalein derivatives as novel covalent inhibitors of SARS CoV-2 Mpro: Structure-activity relationships and inhibitory mechanisms	22
1,2,3-Triazolo[4,5-b]aminoquinolines: Design, synthesis, structure, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity, and molecular docking of novel modified tacrines	22
Molecular hybrids of substituted phenylcarbamoylpiperidine and 1,2,4-triazole methylacetamide as potent 15-LOX inhibitors: Design, synthesis, DFT calculations and molecular docking studies	22
Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors	22
Radiopharmaceuticals in Nasopharyngeal Cancer	22
Synthesis, antimicrobial activity and in-silico studies of (1-(1-arylethyl)-1H-1,2,3-triazolyl-2-phenylquinoline-4-carboxylate derivatives with click chemistry	22
Polydatin sensitizes osteosarcoma cells to methotrexate through suppressing the H19/H3K27me3/H3K9me3 mediated folate metabolism regulatory axis	22
Anti-necroptosis and anti-ferroptosis compounds from the Deep-Sea-Derived fungus Aspergillus sp. MCCC 3A00392	22
Discovery of a novel CDK4/6 and HDAC dual-targeting agent for the treatment of hepatocellular carcinoma	22
Discovery of novel protein degraders based on bioorthogonal reaction-driven intracellular self-assembly strategy	22
Novel N or N modified α-carboline analogues as potential ligands in Alzheimer's disease therapy: Synthesis and neurobiological activity evaluation	22
Design and development of benzyl piperazine linked 5-phenyl-1,2,4-triazole-3-thione conjugates as potential agents to combat Alzheimer’s disease	22
Recent advances in targeting leucine-rich repeat kinase 2 as a potential strategy for the treatment of Parkinson’s disease	22
Comprehensive evaluation of S-glyco-modification in vitro based on the potential impacts to Michael addition	22
In vitro activity and cell death mechanism induced by acrylonitrile derivatives against Leishmania amazonensis	22
Synthesis, structural, multitargeted molecular docking analysis of anti-cancer, anti-tubercular, DNA interactions of benzotriazole based macrocyclic ligand	22
New ε-N-thioglutaryl-lysine derivatives as SIRT5 inhibitors: Chemical synthesis, kinetic and crystallographic studies	22
Hydrophilic and lipophilic colchicinoid formulations for therapy of liver fibrosis in murine model	22
Stable ubiquitin conjugation for biological interrogation of ubiquitinated tau repeat domain	21
Synthesis, X-ray, antioxidant, in-vitro biological & in-silico docking studies of novel organoselenides: Promising colorectal cancer inhibitors	21
Novel xanthine oxidase inhibitory peptides derived from whey protein: identification, in vitro inhibition mechanism and in vivo activity validation	21
Discovery of new 2-(3-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazole derivatives with potential analgesic and anti-inflammatory activities: In vitro, in vivo and in silico investigations	21
Tryptanthrins as multi-bioactive agents: discovery, diversity distribution and synthesis	21
Discovery of ent-kaurane diterpenoid glucosides as potent analgesics from the leaves of Pieris formosa	21
Insights into the dual inhibitory effects of phenylethanoid glycosides from Osmanthus fragrans flower on glycolipid metabolizing enzymes	21
Anti-proliferative tirucallane triterpenoids from gum resin of Boswellia sacra	21
Development and biological evaluation of 68Ga-labeled peptides for potential application in HER2-positive colorectal cancer	21