Bioorganic Chemistry

Article	Citations
Effect of lathyrane-type diterpenoids in neural stem cell physiology: Microbial transformations, molecular docking and dynamics studies	250
New N-Alkylketonetetrahydroisoquinoline derivatives exhibits antitumor effect by HA-CD44 interaction inhibition in MDA-MB-231 breast cancer	168
The first attempt in synthesis, identification, and evaluation of SEPT9 inhibitors on human oral squamous carcinomas	106
Synthesis and biological evaluation of 4-((3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)quinoline derivatives as novel potential transforming growth factor-β type 1 receptor inhibitors for hepatoc	94
Design, synthesis, crystal structure, fungicidal activity, and mechanism of action of novel thiazole-based hydrazide derivatives containing the 4-aminoquinazoline moiety	93
Design, synthesis, and biological evaluation of novel FGFR1 PROTACs	89
Exploration of triazole derivatives, SAR profiles, and clinical pipeline against Mycobacterium tuberculosis	84
Design, synthesis, and biological evaluation of novel thiourea derivatives as small molecule inhibitors for prostate specific membrane antigen	78
Electron-rich anilines as cleavable linkers for peptides	77
Heterologous expression of calcium-independent mesophilic α-amylase from Priestia megaterium: Immobilization on genipin-modified multi-walled carbon nanotubes and silica supports to enhance thermostab	77
Recent advancements in the quest of benzazoles as anti-Mycobacterium tuberculosis agents	75
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis	73
Exploring i-Motif DNA binding with benzothiazolino Coumarins: Synthesis, Screening, and spectroscopic insights	73
Targeting Wnt signaling pathway with small-molecule therapeutics for treating osteoporosis	71
Discovery of highly oxygenated cytochalasans with antiproliferative activity from an endophytic fungus Boeremia exigua	71
Design, synthesis, antimalarial activity, and in-silico studies of new benzimidazole/pyridine hybrids as dihydrofolate reductase inhibitors	70
N-Heterocyclic functionalized chalcone derivatives as anti-inflammatory agents for atopic dermatitis treatment by inhibiting JAK1/STAT3 signaling pathway	70
Development and therapeutic potential of DNA-dependent protein kinase inhibitors	66
20-Deoxyingenol ester and ether derivatives: Synthesis, properties and cytotoxicity	66
Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition	65
Mahanimbine isolated from Murraya koenigii inhibits P-glycoprotein involved in lung cancer chemoresistance	64
Multi-component forms of the 2nd generation H1 receptor antagonist drug, Bilastine and its enhanced physicochemical characteristics	63
Discovery of novel dihydropyrazole-stilbene derivatives for ameliorating heart failure through modulation of p38/NF-κB signaling pathway	63
Discovery of quorum sensing inhibitors against Pseudomonas aeruginosa from Aspergillus sp. NB12	62
SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells	61

Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects	59
One pot domino synthesis of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thiones (THTTs) as anti-inflammatory and antinociceptive candidates: A proof from in-vivo to in-vitro and in-silico	58
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis	57
Topoisomerase II inhibitors design: Early studies and new perspectives	57
Peptide Nucleic Acids: Recent Developments in the Synthesis and Backbone Modifications	57
Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study	56
Lipopeptides production by a newly Halomonas venusta strain: Characterization and biotechnological properties	55
Recent developments of P-glycoprotein inhibitors and its structure–activity relationship (SAR) studies	54
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress	54
Cholinesterase inhibitors assessment of aporphine alkaloids from Annona crassiflora and molecular docking studies	53
Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary s	53
Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents	53
Tetrahydrocarbazoles incorporating 5-arylidene-4-thiazolinones as potential antileukemia and antilymphoma targeting tyrosine kinase and tubulin polymerase enzymes: Design, synthesis, structural, biolo	52
Corrigendum to “Synthesis and broad-spectrum biocidal effect of novel gemini quaternary ammonium compounds” [Bioorg Chem. 151 (2024) 107646]	52
Recent advances in the natural product analogues for the treatment of neurodegenerative diseases	52
Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa	52
Synthesis of 3-hydroxy-4-pyridinone hexadentate chelators, and biophysical evaluation of their affinity towards lipid bilayers	52
Y9, a Gboxin analog, displays anti-tumor effect in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis	52
Identification of sanguinarine as c-MYC transcription inhibitor through enhancing the G-quadruplex-NM23-H2 interactions	52
Issue TOC	51
Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7β substituted steroids	51
Structurally diverse phenylpropanoyl phloroglucinol derivatives from Mallotus philippensis and their anti-bacterial activities	51
Development of an at-line coupling of LC-QTOF-ESI-MS/MS to steroid 5-alpha reductase inhibition assay, a fast bioactive targeting and guided purification of natural complex sample, Impatiens balsamina	51
Synthesis, in vitro anticancer activity and in silico studies of certain isoxazole-based carboxamides, ureates, and hydrazones as potential inhibitors of VEGFR2	50
Antiproliferative activity, enzymatic inhibition and apoptosis-promoting effects of benzoxazole-based hybrids on human breast cancer cells	50
Synthesis, biological evaluation, and molecular docking study of some new rohitukine analogs as protein tyrosine phosphatase 1B inhibitors	49
Discovery of new pyrimido[5,4-c]quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies	49
Novel indazole derivatives as potent apoptotic antiproliferative agents by multi-targeted mechanism: Synthesis and biological evaluation	49
Design, synthesis, and biological evaluation of hydroxamic acid-substituted 2,4-diaryl aminopyrimidines as potent EGFRT790M/L858R inhibitors for the treatment of NSCLC	48
Synthesis of N-methylpyridine-chlorofuranformamide analogs as novel OPG up-regulators and inhibitors of RANKL-induced osteoclastogenesis	47
An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94	47
Discovery of new small molecule inhibitors of the BPTF bromodomain	47
Identification of (E)-1-((1H-indol-3-yl)methylene)-4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents	47
Editorial Board	47
Design, synthesis and biological evaluation of alkynyl-containing maleimide derivatives for the treatment of drug-resistant tuberculosis	47
Discovery of N-arylcinnamamides as novel erythroblast enucleation inducers	47
Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells	47
seco-Sesquiterpenes and acorane-type sesquiterpenes with antiviral activity from the twigs and leaves of Illicium henryi Diels	46
3-Imino derivative-sulfahydantoins: Synthesis, in vitro antibacterial and cytotoxic activities and their DNA interactions	46
Issue TOC	46
Issue TOC	45
The C-terminal segment of Leishmania major HslU: Toward potential inhibitors of LmHslVU activity	45
Protecting-group free synthesis of glycoconjugates displaying dual fungicidal and plant defense-eliciting activities	45
Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRα-targeted anti-mitotic agents	44
Editorial Board	44
Discovery of novel 1H-benzo[d]imidazole-4,7-dione based transglutaminase 2 inhibitors as p53 stabilizing anticancer agents in renal cell carcinoma	44
Nanotechnology applications for treatment of hepatic infections via modulating Hepatic histopathological and DNA alterations	44
Mn-doped bimetallic synergistic catalysis boosts for enzymatic phosphorylation of N-Acetylglucosamine/ N-Acetylgalactosamine and their derivatives	43
Development of novel androgen receptor antagonists based on the structure of darolutamide	42
Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach	42

Issue TOC	42
Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction	42
Issue TOC	41
Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a mult	41
Editorial Board	41
Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors	41
Synthesis and antitubercular activity of novel 4-arylalkyl substituted thio-, oxy- and sulfoxy-quinoline analogues targeting the cytochrome bc1 complex	41
Issue TOC	40
Discovery of hepatoprotective activity components from Thymus quinquecostatus celak. by molecular networking, biological evaluation and molecular dynamics studies	40
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF-κB pathway	40
A novel benzothiophene incorporated Schiff base acting as a “turn-on” sensor for the selective detection of Serine in organic medium	39
Discovery of novel 1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors with hypouricemic effects	39
Discovery of a minimalistic DIE-based fluorescent probe for detection of parallel G-quadruplex forms	39
Targeting the kinetics mechanism of AMPA receptor inhibition by 2-oxo-3H-benzoxazole derivatives	39
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation	39
Affinity-based protein profiling-driven discovery of myricanol as a Nampt activator	39
Structure-activity relationships and antiproliferative effects of 1,2,3,4-4H-quinoxaline derivatives as tubulin polymerization inhibitors	39
Biocatalytic one pot three component approach: Facile synthesis, characterization, molecular modelling and hypoglycemic studies of new thiazolidinedione festooned quinoline analogues catalyzed by alka	39
Nitric oxide inhibitory phenolic constituents isolated from the roots and rhizomes of Notopterygium incisum	38
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation	37
Biological activity and ADME/Tox prediction of some 2-substituted benzoxazole derivatives	37
Carbazole-based mitochondria-targeted fluorescent probes for in vivo viscosity and cyanide detection in cells and zebrafish	36
Synthesis and in vitro cytotoxic activity of dye-linker-macrocycle conjugates with variable linker length and components	35
Inhibition of TGF-β1/Smad3 signaling by compound 5aa: A potential treatment for idiopathic pulmonary fibrosis	35
Rosmarinic acid turned α-syn oligomers into non-toxic species preserving microtubules in Raw 264.7 cells	35
Membrane interactions in Alzheimer’s disease treatment strategies with multitarget molecules	35
Rational development of an ESIPT-based fluorescent probe with large Stokes shift for imaging of hydrogen sulfide in live cells	35
Novel 131-iodine labeled and ultrasound-responsive nitric oxide and reactive oxygen species controlled released nanoplatform for synergistic sonodynamic/nitric oxide/chemodynamic/radionuclide therapy	35
Nitroreductase-induced bioorthogonal ligation for prodrug activation: A traceless strategy for cancer-specific imaging and therapy	35
Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma	35
Water-soluble alkaloids isolated from Portulaca oleracea L.	35
Design, synthesis, and biological evaluation of carbonyl-hydrazine-1-carboxamide derivatives as anti-hepatic fibrosis agents targeting Nur77	35
Transforming iodoquinol into broad spectrum anti-tumor leads: Repurposing to modulate redox homeostasis	34
Design, synthesis, and biological activities of arecoline derivatives containing 1,3,4-oxadiazole structure	34
Design and synthesis of 9-phenanthranilamide derivatives and the study of anti-inflammatory, antioxidant and neuroprotective activities	34
Synthesis and biological evaluation of heterocyclic ring-fused dammarane-type ginsenoside derivatives as potential anti-tumor agents	34
Tetrahydropyridine appended 8-aminoquinoline derivatives: Design, synthesis, in silico, and in vitro antimalarial studies	34
Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators	34
Cephalostatins and ritterazines: Distinctive dimeric marine-derived steroidal pyrazine alkaloids with intriguing anticancer activities	34
Heteryunine A, an amidated tryptophan-catechin-spiroketal hybrid with antifibrotic activity from Heterosmilax yunnanensis	34
Bioisosteric ferrocenyl 1,3-thiazolidine-4-carboxylic acid derivatives: In vitro antiproliferative and antimicrobial evaluations	33
Design, synthesis and antitumor activities of phthalazinone derivatives as PARP-1 inhibitors and PARP-1/HDAC-1 inhibitors	33
Design, synthesis and bioevaluation of 1,2,4-thiadiazolidine-3,5-dione derivatives as potential GSK-3β inhibitors for the treatment of Alzheimer's disease	33
Acovenosigenin A β-glucoside mediates JAK2-STAT3 signaling pathway by targeting GP130 in A549 and H460 cells based on integrative analysis of transcriptome and proteome and biological verification	33
A near-infrared, colorimetric and ratiometric fluorescent sensor with high sensitivity to hydrogen peroxide and viscosity for solutions detection and imaging living cells	33
Saponins from Dolichos lablab seeds with anti-inflammatory activity	33
Identification and bioactivity evaluation of miliusanes from Miliusa sinensis	32
Identification of new lead molecules against anticancer drug target TFIIH subunit P8 using biophysical and molecular docking studies	32
Synthesis of water-soluble novel bioactive pyridine-based azo coumarin derivative and competitive cytotoxicity, DNA binding, BSA binding study, and in silico analysis with coumarin	32
Isolation and identification of belamcandaoids A-N from Belamcanda chinensis seeds and their inhibition on extracellular matrix in TGF-β1 induced kidney proximal tubular cells	32
Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing 4-aminothiophenol linker as promising antibacterial agents	32
2-Aminobenzothiazoles in anticancer drug design and discovery	32
Molecular imaging of tumor hypoxia: Evolution of nitroimidazole radiopharmaceuticals and insights for future development	32
Virtual screening of novel mTOR inhibitors for the potential treatment of human colorectal cancer	32
Self-assembled dehydropeptide nanocarrier as a delivery system for antitumor drug temozolomide	31
Design, synthesis and molecular docking study of new pyrimidine-based hydrazones with selective anti-proliferative activity against MCF-7 and MDA-MB-231 human breast cancer cell lines	31
Enhanced antioxidation capacity endowed to a mixed type aldose reductase inhibitor leads to a promising anti-diabetic complications agent	31
Structural simplification and bioisostere principle lead to Bis-benzodioxole-fibrate derivatives as potential hypolipidemic and hepatoprotective agents	31
Secoiridoid dimers and their biogenetic precursors from the fruits of Cornus officinalis with potential therapeutic effects on type 2 diabetes	31
Biotransformations of anthranilic acid and phthalimide to potent antihyperlipidemic alkaloids by the marine-derived fungus Scedosporium apiospermum F41-1	31
New molecular hybrids integrated with quinoxaline and pyrazole structural motifs: VGFR2 inhibitors and apoptosis inducers	31
Design, synthesis and anticancer evaluation of 4-Substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as dual topoisomerase I and II inhibitors	31
SAR study on Novel truxillic acid monoester-Based inhibitors of fatty acid binding proteins as Next-Generation antinociceptive agents	31
Damsin and neoambrosin: Two sesquiterpene lactones with affinity and different activity for PPAR and TRPA1 receptors	30
Assessing the effectiveness of fluorinated and α-methylated 3-boronophenylalanine for improved tumor-specific boron delivery in boron neutron capture therapy	30
Discovery of novel oxindole derivatives as TRPA1 antagonists with potent analgesic activity for pain treatment	30
Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation	29
Hypoglycemic activity and metabolite diversity of Archangium sp. UTMC 4535 with the first report on magnodelavin biosynthesis by bacteria	29
A Glimpse for the subsistence from pandemic SARS-CoV-2 infection	29
Design, synthesis and biological evaluation of novel pyrazolinone derivatives as multifunctional ligands for the treatment of Alzheimer’s disease	29
KAHA ligation as a platform for the rapid discovery of Protein Tyrosine phosphatase 1B (PTP1B) inhibitors	29
Issue TOC	29
The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors	29
Co, Cu, Ni, and Zn complexes of N-[(3-phenoxy phenyl)methylidene]-l-valine as α-glycosidase and α-amylase inhibitors: Synthesis, molecular docking & antimicrobial evaluation	29
Diversity-oriented synthesis of second generation guanidinium-rich transporters toward cell-selective penetration	29
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new anti-vitiligo compounds	28
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity	28
Novel dual-target μ‑opioid and TRPV1 ligands as potential pharmacotherapeutics for pain management	28
Synthesis, antiviral and antitumor activities investigations of a series of Ribavirin C-nucleoside analogue prodrugs	28
New phthalimide-based derivatives as EGFR-TK inhibitors: Synthesis, biological evaluation, and molecular modeling study	27

Molecular hybridization, synthesis, in vitro α-glucosidase inhibition, in vivo antidiabetic activity and computational studies of isatin based compounds	27
Synthesis, in vitro antiurease, in vivo antinematodal activity of quinoline analogs and their in-silico study	27
Antidote-controlled DNA aptamer modulates human factor IXa activity	27
Interaction between CD44 and highly condensed hyaluronic acid through crosslinking with proteins	27
Allyl phenyl selenides as H2O2 acceptors to develop ROS-responsive theranostic prodrugs	27
Novel anti-inflammatory agents featuring phenoxy acetic acid moiety as a pharmacophore for selective COX-2 inhibitors: Synthesis, biological evaluation, histopathological examination and molecular mod	27
Design and synthesis of β-carboline and combretastatin derivatives as anti-neutrophilic inflammatory agents	27
Development of an AIE-active fluorescent probe for the simultaneous detection of Al3+ and viscosity and imaging in Alzheimer’s disease model	26
Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats	26
Old drug, new use: The thalidomide-based fluorescent probe for cysteine detection and imaging in living cells	26
A newly synthesized magnetic nanoparticle coated with glycidyl methacrylate monomer and 1,2,4-Triazole: Immobilization of α-Amylase from Bacillus licheniformis for more reuse, stability, and activity	26
Synthesis and biological evaluation of new nicotinic acid derivatives as potential anti-inflammatory agents with enhanced gastric safety profile	26
Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resi	26
Editorial Board	26
2β-Acetoxyferruginol derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation	26
Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), design, synthesis and biological evaluation of novel PI3Kα selective inhibitors	26
2-Methoxydiol derivatives as new tubulin and HDAC dual-targeting inhibitors, displaying antitumor and antiangiogenic response	26
Pentacyclic triterpene carboxylic acids derivatives integrated piperazine-amino acid complexes for α-glucosidase inhibition in vitro	26
Spectroscopic analysis, kinetic mechanism, computational docking, and molecular dynamics of active metabolites from the aerial parts of Astragalus membranaceusBunge as tyrosinase inhibitors	25
A highly selective probe for ratiometric imaging peroxynitrite in living cells and in vivo	25
Design and synthesis of novel pyridopyrimidine derivatives with anchoring non-coplanar aromatic extensions of EGFR inhibitory activity	25
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway	25
Amino-modified-silica-coated gadolinium-copper nanoclusters, conjugated to AS1411 aptamer and radiolabeled with technetium-99 m as a novel multimodal imaging agent	25
Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies	25
Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway	25
Co-delivery of hesperidin and clarithromycin in a nanostructured lipid carrier for the eradication of Helicobacter pylori in vitro	25
Instrumental and transcriptome analysis reveals the chemotherapeutic effects of doxorubicin-loaded black phosphate nanosheets on abiraterone-resistant prostate cancer	24
Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease	24
The flavonoids from the fruits of Psoralea corylifolia and their potential in inhibiting metastasis of human non-small cell lung cancers	24
Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors	24
Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal	24
Exploring new cyclohexane carboxamides based GABA agonist: Design, synthesis, biological evaluation, in silico ADME and docking studies	24
Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents	24
Novel bisubstrate uridine-peptide analogues bearing a pyrophosphate bioisostere as inhibitors of human O-GlcNAc transferase	24
Discovery of piperine derivatives as inhibitors of human dihydroorotate dehydrogenase to induce ferroptosis in cancer cells	24
In vitro and in vivo antiproliferative activity on lung cancer of two acylhydrazone based zinc(II) complexes	24
Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors	24
Design and synthesis of novel dithiazole carboxylic acid Derivatives: In vivo and in silico investigation of their Anti-Inflammatory and analgesic effects	23
Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway	23
Discovery and evolution of berberine analogues as anti-Helicobacter pylori agents with multi-target mechanisms	23
Small molecules enhancers of amyloid aggregation of C-terminal domain of Nucleophosmin 1 in acute myeloid leukemia	23
A chemoenzymatic process for preparation of highly purified dehydroepiandrosterone in high space-time yield	23
Novel dual-channel ratiometric fluorescence probe for SO2 detection in food and bioimaging applications based on FRET mechanism	23
Synthesis of novel pyrimidine-based Schiff base complexes: Targeting Amyloid-β aggregation in Alzheimer’s disease	23
Discovery of stylissatin A analogs exhibiting potent nitric oxide inhibition	23
Anti-inflammatory activity of fluorine-substituted benzo[h]quinazoline-2-amine derivatives as NF-κB inhibitors	23
Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure	23
Triazole derivatives inhibit the VOR complex-mediated nuclear transport of extracellular particles: Potential application in cancer and HIV-1 infection	23
Assessing p-tolyloxy-1,3,4-oxadiazole acetamides as lipoxygenase inhibitors assisted by in vitro and in silico studies	23
Novel linezolid-based oxazolidinones as potent anticandidiasis and antitubercular agents	23
Coumarin-based fluorescent probes for the detection of copper (II) and imaging in mice of Wilson’s disease	23
The RIP3 activator C8 regulates the autophagy flux mediated by p62 and promotes the immunogenic form of cell death in human gastric cancer cells	23
Regioselectivity in inhibition of peptide deformylase from Haemophilus influenzae by 4- vs 5-azaindole hydroxamic acid derivatives: Biochemical, structural and antimicrobial studies	23
A comparative study of diaryl urea molecules with and without sulfonamide group on Carbonic anhydrase IX and XII inhibition and its consequence on breast cancer cells	23
Discovery of novel biphenyl-sulfonamide analogues as NLRP3 inflammasome inhibitors	23
Synthesis, photochemistry and computational study of novel 1,2,3-triazole heterostilbenes: Expressed biological activity of their electrocyclization photoproducts	23
Synthesis, bio-physical and anti-leishmanial studies of some novel indolo[3,2-a]phenanthridine derivatives	23
Design, synthesis and biological evaluation of N-(4-alkoxy-3-(1H-tetrazol-1-yl)phenyl) heterocyclic aromatic amide derivatives as xanthine oxidase inhibitors	23
Chemical synthesis, biological activities and action on nuclear receptors of 20S(OH)D3, 20S,25(OH)2D3, 20S,23S(OH)2D3 and 20S,23R(OH)2D3	23
Unsaturated lipids modulating the interaction of the antileishmanial isolinderanolide E with models of cellular membranes	23
Dimethoxyindoles based thiosemicarbazones as multi-target agents; synthesis, crystal interactions, biological activity and molecular modeling	22
6-C-Linked trehalose glycolipids signal through Mincle and exhibit potent adjuvant activity	22
High-level expression of a novel multifunctional GH3 family β-xylosidase/α-arabinosidase/β-glucosidase from Dictyoglomus turgidum in Escherichia coli	22
The discovery of potentially active diterpenoids to inhibit the pyroptosis from Callicarpa arborea	22
Synthesis, antitumor activity evaluation of 2-selenocyano-3-selenocyanoalkyloxyestradiols with a bisselenocyanate structure	22
Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors	22
Advances in drug discovery of flavivirus NS2B-NS3pro serine protease inhibitors for the treatment of Dengue, Zika, and West Nile viruses	22
Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity	22
13C NMR-based dereplication using MixONat software to decipher potent anti-cholinesterase compounds in Mesua lepidota bark	22
Proliferatins suppress lipopolysaccharide-induced inflammation via inhibition of the NF-κB and MAPK signaling pathways	22
Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage	22
Bioassay-guided isolation of anti-leukemic steroids from Aglaia abbreviata by inducing apoptosis	22
Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis	21
Discovery of nor-bicyclic polyprenylated acylphloroglucinols possessing diverse architectures with anti-hepatoma activities from Hypericum patulum	21
Disaccharide-polyethylenimine organic nanoparticles as non-toxic in vitro gene transporters and their anticancer potential	21
Scaffold overlay of flavonoid-inspired molecules: Discovery of 2,3-diaryl-pyridopyrimidin-4-imine/ones as dual hTopo-II and tubulin targeting anticancer agents	21
Discovery of berberine analogs as potent and highly selective p300/CBP HAT inhibitors	21
Natural product protulactone A: Total synthesis from D-galactose, X-ray analysis and biological evaluation	21
Study of G protein-coupled receptors dimerization: From bivalent ligands to drug-like small molecules	21
Discovery of new chalone adamantyl arotinoids having RXRα-modulating and anticancer activities	21
Efficient biosynthesis of Vibegron intermediate using a novel carbonyl reductase based on molecular modification of hydrogen bonding network regulation	21
Design, synthesis and biological evaluation of selective histone deacetylase 6 (HDAC6) inhibitors bearing benzoindazole or pyrazoloindazole scaffold as surface recognition motif	21
Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition	21
Advancements in folate receptor targeting for anti-cancer therapy: A small molecule-drug conjugate approach	21
99mTc- Anionic dendrimer targeted vascular endothelial growth factor as a novel nano-radiotracer for in-vivo breast cancer imaging	21
EZH2 serves as a promising therapeutic target for fibrosis	21
Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine kinase activity and molecula	21
Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents	21
Procerolides A-B from Microcionidae marine sponge Clathria procera: Anti-inflammatory macrocylic lactones with selective cyclooxygenase-2 attenuation properties	21
Co-based carbon material as CYP3A4-like nanozyme with both biocatalytic activity and inhibition behaviors	21
Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility	21
Discovery of a near-infrared fluorescent probe for G-quadruplexes by exploiting the concept of unfolding-intramolecular-aggregation-induced emission	21
X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles	21
The discovery of novel sanjuanolide derivatives as chemotherapeutic agents targeting castration-resistant prostate cancer	21
Discovery of a novel GRPR antagonist for protection against cisplatin-induced acute kidney injury	21