Mechanisms of Ageing and Development

Article	Citations
Characterization of a natural model of adult mice with different rate of aging	144
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study	102
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT	95
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice	92
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	88
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans	78
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	77
The role of cytokines/chemokines in an aging skin immune microenvironment	69
Impact of age and gender on glioblastoma onset, progression, and management	68
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress	68
Coenzyme Q10 supplementation – In ageing and disease	67
Brain aging mechanisms with mechanical manifestations	61
Strategies for late phase preclinical and early clinical trials of senolytics	59
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases	56
Editorial Board	54
Sex differences in neuroimmunoendocrine communication. Involvement on longevity	52
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints	51
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe	51
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years	51
The role of mitochondria in cytokine and chemokine signalling during ageing	48
Molecular mechanisms and potential interventions during aging-associated sarcopenia	43
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways	39
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl	38
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	38
Senescence of skeletal stem cells and their contribution to age-related bone loss	37

Recent advances in the discovery of senolytics	37
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways	37
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity	36
Vascular participation in bone healing: Implications related to advancing age and morbidity	36
Decreased oxidative stress response and oxidant detoxification of skin during aging	35
Editorial Board	35
Living in endemic area for infectious diseases accelerates epigenetic age	32
Towards defining optimal concentrations of micronutrients in adults to optimize health	31
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response	31
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role	31
Inflammaging: The lesson of COVID-19 pandemic	30
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling	29
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease	29
Editorial Board	29
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of	29
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]	28
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients	28
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans	28
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory	27
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder	26
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury	26
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus	26
The link between obesity and aging - insights into cardiac energy metabolism	26
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox	26
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts	26
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project	25
A novel platform for precise senolysis	25
Toward a multidisciplinary science of aging biology	24
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives	24
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses	24
Improving intestinal inflammaging to delay aging? A new perspective	24
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1	24
Ferulic acid and hormesis: Biomedical and environmental implications	24
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites	23
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data	23
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?	23
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?	22
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too	22
Editorial Board	21
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age	21
Editorial Board	21
Evaluation of senescent cells in intervertebral discs by lipofuscin staining	21
Genistein, a tool for geroscience	21
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila	21
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction	21
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids	20
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice	20
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues	20
A quantile frailty index without dichotomization	20
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	19

Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue	19
Risks and rewards of targeting NAD+ homeostasis in the brain	19
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence	18
Age-related activity of Poly (ADP-Ribose) Polymerase (PARP) in men with localized prostate cancer	18
Lipids and the hallmarks of ageing: From pathology to interventions	18
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy	18
Fatty acid desaturation is essential for C. elegans longevity at high temperature	18
Editorial Board	17
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6	17
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors	17
Caloric restriction enhances vascular tone of cerebral and mesenteric resistance arteries in aged rats	17
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]	17
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology	16
Cellular senescence in vascular wall mesenchymal stromal cells, a possible contribution to the development of aortic aneurysm	16
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review	16
Fecal microbiota transplantation holds the secret to youth	16
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment	16
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome	16
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration	15
EDITORIAL Special Issue: The influence of biological sex in ageing	15
The emerging importance of lymphangiogenesis in aging and aging-associated diseases	15
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’	15
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus	15
The role of senolytics in osteoporosis and other skeletal pathologies	15
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components	15
Senotherapeutics: Targeting senescent cells for the main age-related diseases	15
Senolytic drugs: Beyond the promise and the hype	15
Signs of diastolic dysfunction are graded by serum testosterone levels in aging C57BL/6 male mice	15
Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids	14
The influence of inflammation and frailty in the aging continuum	14
Cellular senescence and premature aging in Down Syndrome	14
Progresses in both basic research and clinical trials of NAD+ in Parkinson’s disease	14
The tumor suppression theory of aging	13
A guide to senolytic intervention in neurodegenerative disease	13
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice	13
Differential Plin5 response to high-fat diet in cardiomyocytes isolated from young and aged mice	13
The potential of Senolytics in transplantation	13
Single-cell analysis of human peripheral blood reveals high immune response activity in successful ageing individuals	13
SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience	13
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4	13
Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke	13
Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology	12
Age-associated anatomical and physiological alterations in Caenorhabditis elegans	12
Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes	12
Editorial Board	11
Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy	11
Do motoneuron discharge rates slow with aging? A systematic review and meta-analysis	11
In the land of not-unhappiness: On the state-of-the-art of targeting aging and age-related diseases by biomedical research	11
Counteracting aged DNA methylation states to combat ageing and age-related diseases	11
Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans	11
Social environment improves the cytokine profile and lymphoproliferative response in chronologically old and prematurely aging mice	11
Inflammaging score as a potential prognostic tool for cancer: A population-based cohort study	11
miR-26a deficiency is associated with bone loss and reduced muscle strength but does not affect severity of cartilage damage in osteoarthritis	11
Deuterated polyunsaturated fatty acids provided protection against oxidative stress in ocular fibroblasts derived from glaucoma patients	10
Editorial Board	10
Editorial Board	10
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions	10
Editorial Board	10
Corrigendum to “Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6 J mice. A potential model of sporadic Alzheimer’s disease” [J. Mech. Agei	10
Role of stem cells in ageing and age-related diseases	10
Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation	10
Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts	9
Age-associated proinflammatory elastic fiber remodeling in large arteries	9
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases	9
Editorial Board	9
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review	9
miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence	9
Role and mechanism of TXNIP in ageing-related renal fibrosis	9
Ageing: Not only an age-related issue	9
No association between frailty index and epigenetic clocks in Italian semi-supercentenarians	9
Frailty and cytokines in preclinical models: Comparisons with humans	9
Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice	9
Immunosenescence and COVID-19	8
Entropy modulation of electroencephalographic signals in physiological aging	8
Common and distinct metabolomic markers related to immune aging in Western European and East African populations	8
Relation of the kynurenine pathway with normal age: A systematic review	8
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice	8
Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP	8
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila	8
Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapy	8

Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia	8
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration	7
The cGAS-STING signaling pathway is modulated by urolithin A	7
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	7
Editorial Board	7
Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3	7
Comparative analysis of fat composition in marrow, serum, and muscle from aging C57BL6 mice	7
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology	7
A role for estrogen in skin ageing and dermal biomechanics	7
Corrigendum to “Characterization of a natural model of adult mice with different rate of aging” [Mech. Ageing Dev. 222 (2024), 111991]	7
Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics	7
HRasV12 induces apoptosis, not cellular senescence in mouse skeletal myoblasts	7
Interleukin-23 mediates the reduction of GADD45a expression to attenuate oxidative stress-induced cellular senescence in human fibroblasts	7
New frontiers in ageing and longevity: Sex and gender medicine	7
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	7
Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target	6
Plasma cfDNA abundance as a prognostic biomarker for higher risk of death in geriatric cardiovascular patients	6
Sleep disorders and Alzheimer’s disease pathophysiology: The role of the Glymphatic System. A scoping review	6
Editorial Board	6
Challenges of infectious diseases in older adults: From immunosenescence and inflammaging through antibiotic resistance to management strategies	6
Navigating oligodendrocyte precursor cell aging in brain health	6
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway	6
Antigen presentation capability and AP-1 activation accompany methotrexate-induced colon cancer cell senescence in the context of aberrant β-catenin signaling	6
Editorial Board	6
A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer’s disease, and improve its treatment	6
Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases	6
Sex differences in frailty: Comparisons between humans and preclinical models	6
Vascular ageing and the related complications in the brain: New insights on related mechanisms and their translational applications	6
The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis	6
Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells	6
The damage-independent evolution of ageing by selective destruction	6
Lack of activity of the mitochondrial large-conductance calcium-regulated potassium channels in senescent vascular smooth muscle cells.	6
The old guard: Age-related changes in microglia and their consequences	6
Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis	6
The role of NAD+ metabolism in macrophages in age-related macular degeneration	6
Pan-tissue methylation aging clock: Recalibrated and a method to analyze and interpret the selected features	6
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence	6
Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols	5
Current approaches of anti-age related diseases: From molecules up to whole organism	5
Role of cytokines and reactive oxygen species in brain aging	5
The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop	5
Sirtuin 3 drives sex-specific responses to age-related changes in mouse embryonic fibroblasts	5
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model	5
Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer’s disease	5
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy	5
Sex-dependent deterioration of cardiac function and molecular alterations in age- and disease-associated RAGE overexpression	5
Editorial Board	5
Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice	5
Fall of PARP3 restrains Lgr5+ intestinal stem cells proliferation and mucosal renovation in intestinal aging	5
Understanding Alzheimer’s disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study	5
Pathological implication of CaMKII in NF-κB pathway and SASP during cardiomyocytes senescence	5
The impact of opioids on the hallmarks of ageing	5
A blast from the past: To tame time with metformin	5