Mechanisms of Ageing and Development

Article	Citations
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1	136
Potential protein biomarkers in saliva for detection of frailty syndrome by targeted proteomics	125
Characterization of a natural model of adult mice with different rate of aging	96
Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation	83
Aging: A struggle for beneficial to overcome negative factors made by muscle and bone	83
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses	82
Editorial Board	73
From cue to meaning: The involvement of POLD1 gene in DNA replication, repair and aging	67
The sex-associated burden of atherosclerotic cardiovascular diseases: An update on prevention strategies	66
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT	63
Editorial Board	63
Editorial Board	61
Sex-dependent deterioration of cardiac function and molecular alterations in age- and disease-associated RAGE overexpression	58
Calcium transferring from ER to mitochondria via miR-129/ITPR2 axis controls cellular senescence in vitro and in vivo	53
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model	53
Editorial Board	50
Ageing-induced hypercontractility is related to functional enhancement of STIM/Orai and upregulation of Orai 3 in rat and human penile tissue	50
The role of cytokines/chemokines in an aging skin immune microenvironment	49
The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop	48
Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts	47
Impact of ageing, fall history and exercise on postural reflexes following unpredictable perturbations: A systematic review and meta-analyses	46
Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training	43
Editorial Board	41
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice	37
Ageing: Not only an age-related issue	37

Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease	36
Sestrin2 plays a protective role in age-related hearing loss by inhibiting NLRP3-inflammasome activity	36
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans	35
Toward a multidisciplinary science of aging biology	34
A blast from the past: To tame time with metformin	34
No association between frailty index and epigenetic clocks in Italian semi-supercentenarians	33
Ferulic acid and hormesis: Biomedical and environmental implications	32
Rodent diet aids and the fallacy of caloric restriction	31
Calorie restriction changes the anxiety-like behaviour of ageing male Wistar rats in an onset- and duration-dependent manner	30
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study	29
Impact of age and sex on hyperoxia-induced cardiovascular pathophysiology	28
Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice	28
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	28
Age-associated proinflammatory elastic fiber remodeling in large arteries	27
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data	27
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review	27
Potential genetic biomarkers are found to be associated with both cognitive function and blood pressure: A bivariate genome-wide association analysis	27
A new mechanistic insight into fate decisions during yeast cell aging process	27
The impact of opioids on the hallmarks of ageing	26
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases	26
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?	26
Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances	26
Adipose tissue senescence: Biological changes, hallmarks and therapeutic approaches	26
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites	25
Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle	25
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age	25
Prenatal exposure to CB2 receptors agonist differentially impacts male and female germ cells via histone modification	24
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too	24
Corrigendum to “Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6 J mice. A potential model of sporadic Alzheimer’s disease” [J. Mech. Agei	24
Brain aging mechanisms with mechanical manifestations	23
Sirtuin 3 drives sex-specific responses to age-related changes in mouse embryonic fibroblasts	23
Evaluation of senescent cells in intervertebral discs by lipofuscin staining	22
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress	22
Impact of age and gender on glioblastoma onset, progression, and management	22
Strategies for late phase preclinical and early clinical trials of senolytics	21
Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin/IGF-1-like signaling in C. elegans	21
Coenzyme Q10 supplementation – In ageing and disease	21
Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice	21
Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations	20
Exploring the interplay between metabolomics and genetics in Parkinson's disease: Insights from ongoing research and future avenues	20
RNA-binding proteins in cellular senescence	20
Role and mechanism of TXNIP in ageing-related renal fibrosis	20
Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic	20
Frailty and cytokines in preclinical models: Comparisons with humans	20
Sex and gender differences in Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis: A narrative review	19
Aging – What it is and how to measure it	19
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila	18
Lipids and the hallmarks of ageing: From pathology to interventions	18
The biological relevance of pigment epithelium-derived factor on the path from aging to age-related disease	18
Editorial Board	18

Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials	18
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	18
The role of the LINC complex in ageing and microgravity	18
Fatty acid desaturation is essential for C. elegans longevity at high temperature	18
Editorial Board	17
Preserving the discreteness of deficits during coding leads to a lower frailty index in individuals living in long-term care	17
Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation	17
Editorial Board	17
Editorial Board	17
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases	17
Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study	17
Editorial	16
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice	16
Frailty syndrome: A target for functional nutrients?	16
Editorial Board	16
Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes	15
Novel 18-norspirostane steroidal saponins: Extending lifespan and mitigating neurodegeneration through promotion of mitophagy and mitochondrial biogenesis in Caenorhabditis elegans	15
Relation of the kynurenine pathway with normal age: A systematic review	15
What researchers on ageing should know about multimorbidity, geroprotectors and artificial intelligence	15
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice	15
Editorial Board	15
Elucidating the role of chemokines in inflammaging associated atherosclerotic cardiovascular diseases	14
Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging	14
Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells	14
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	14
The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells	14
Sex differences in neuroimmunoendocrine communication. Involvement on longevity	14
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila	14
A quantile frailty index without dichotomization	14
The role of mitochondria in cytokine and chemokine signalling during ageing	13
Molecular mechanisms and potential interventions during aging-associated sarcopenia	13
Immunosenescence and COVID-19	13
Oral frailty indicators and cardio- and cerebrovascular diseases in older age: A systematic review	13
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues	13
Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy	13
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue	12
The role of cellular senescence in tissue repair and regeneration	12
Blood donation improves skin aging through the reduction of iron deposits and the increase of TGF-β1 in elderly skin	12
Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease	12
Editorial Board	11
Entropy modulation of electroencephalographic signals in physiological aging	11
Long-term caloric restriction ameliorates T cell immunosenescence in mice	11
Genistein, a tool for geroscience	11
The impact of sleep and exercise on brain atrophy in mild cognitive impairment	11
Understanding the (epi)genetic dysregulation in Parkinson's disease through an integrative brain competitive endogenous RNA network	11
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids	11
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years	10
Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia	10
The close relationship between oocyte aging and telomere shortening, and possible interventions for telomere protection	10
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints	10
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe	10
Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging	10
Protective effects of apigenin on the brain transcriptome with aging	10
SIRT-associated attenuation of cellular senescence in vascular wall	10
Deciphering Osteosarcopenia through the hallmarks of aging	10
Breathe it in – Spotlight on senescence and regeneration in the lung	9
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence	9
DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions	9
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration	9
Lifestyle factors and metabolomic aging biomarkers: Meta-analysis of cross-sectional and longitudinal associations in three prospective cohorts	9
Time-dependent effects of high-fat diet on cognition and cerebral insulin signaling: Window for recovery and potential therapeutic target	9
Cardiovascular health is associated with the epigenetic clock in the Berlin Aging Study II (BASE-II)	9
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome	9
Amyloid-β1-40 differentially stimulates proliferation, activation of oxidative stress and inflammatory responses in male and female hippocampal astrocyte cultures	9
Risks and rewards of targeting NAD+ homeostasis in the brain	9
The age-related characteristics in bone microarchitecture, osteoclast distribution pattern, functional and transcriptomic alterations of BMSCs in mice	9
Restoring the endothelial barrier function in the elderly	8
Editorial Board	8
Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging	8
Luteolin and hormesis	8
Mechanisms of mitochondrial microRNA regulation in cardiovascular diseases	8
Genome-wide association analysis of cognitive function in Danish long-lived individuals	8
Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP	8
Mitigating the effects of time in the heart and liver: The variable effects of short- and long-term caloric restriction	8
Editorial Board	8
Cellular senescence in vascular wall mesenchymal stromal cells, a possible contribution to the development of aortic aneurysm	8
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways	8
Common and distinct metabolomic markers related to immune aging in Western European and East African populations	8
Age-related activity of Poly (ADP-Ribose) Polymerase (PARP) in men with localized prostate cancer	7
The cGAS-STING signaling pathway is modulated by urolithin A	7

Caloric restriction enhances vascular tone of cerebral and mesenteric resistance arteries in aged rats	7
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6	7
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy	7
Comparative analysis of fat composition in marrow, serum, and muscle from aging C57BL6 mice	7
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl	7
Effect of change of interleukin-6 over time on gait speed response: Results from the lifestyle interventions and independence for elders study	7
Senescence of skeletal stem cells and their contribution to age-related bone loss	7
Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus	6
Unlocking diagnosis of sarcopenia: The role of circulating biomarkers – A clinical systematic review	6
Cardiac iron metabolism during aging – Role of inflammation and proteolysis	6
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review	6
Brain health promotion: Tactics within a strategic approach based upon valid, yet evolving scientific evidence	6
Sarcopenia: A dive into metabolism to promote a multimodal, preventive, and regenerative approach	6
The telomere connection between aging and cancer: The burden of replication stress and dysfunction	6
The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells	6
Reproductive aging and telomeres: Are women and men equally affected?	6
Convergence between brain aging and Alzheimer’s disease: Focus on mitochondria	6
Cyanidin-3-O-glucoside promotes stress tolerance and lifespan extension of Caenorhabditis elegans exposed to polystyrene via DAF-16 pathway	6
IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival	6
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]	5
Recent advances in the discovery of senolytics	5
Fecal microbiota transplantation holds the secret to youth	5
A role for estrogen in skin ageing and dermal biomechanics	5
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	5
Role of chemokines in aging and age-related diseases	5
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity	5
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	5
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	5
Senolytic targets and new strategies for clearing senescent cells	5
Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics	5
Corrigendum to “Molecular mechanisms in cognitive frailty: Potential therapeutic targets for oxygen-ozone treatment” [Mech. Ageing Dev. 186 (2020) 111210]	5
Heart of the matter: Mitochondrial dynamics and genome alterations in cardiac aging	5
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors	5
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology	5
Interleukin-23 mediates the reduction of GADD45a expression to attenuate oxidative stress-induced cellular senescence in human fibroblasts	5
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration	4
Aberrant expression of messenger and small noncoding RNAomes in aged skin of rats	4
Decreased oxidative stress response and oxidant detoxification of skin during aging	4
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response	4
Editorial Board	4
Editorial Board	4
Neurodegeneration & imperfect ageing: Technological limitations and challenges?	4
Long-COVID-19 autonomic dysfunction: An integrated view in the framework of inflammaging	4
Vascular ageing and the related complications in the brain: New insights on related mechanisms and their translational applications	4
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology	4
Navigating oligodendrocyte precursor cell aging in brain health	4
Corrigendum to “Characterization of a natural model of adult mice with different rate of aging” [Mech. Ageing Dev. 222 (2024), 111991]	4
New frontiers in ageing and longevity: Sex and gender medicine	4
Editorial Board	4
Editorial Board	4
Editorial Board	4
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment	4
Sortilin/Omentin-1 ratio in peripheral artery disease: A cross-sectional study on 295 unselected elderly patients	4
A mechanistic analysis of metformin's biphasic effects on lifespan and healthspan in C. elegans: Elixir in youth, poison in elder	4
Mitochondrial transplantation improves anxiety- and depression-like behaviors in aged stress-exposed rats	4
Sex-specific effects of high-fat diet on rat brain glucose metabolism and early-onset dementia symptoms	4
Editorial Board	4
Dietary restriction and ageing: Recent evolutionary perspectives	4