Mechanisms of Ageing and Development

Article	Citations
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs	112
Characterization of a natural model of adult mice with different rate of aging	80
Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing	63
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress	59
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT	59
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice	59
The role of cytokines/chemokines in an aging skin immune microenvironment	51
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study	49
Impact of age and gender on glioblastoma onset, progression, and management	46
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	44
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases	43
Mechanism of FTO-mediated m6A demethylation regulation of YAP1 in nucleus pulposus cell senescence	42
Sex differences in neuroimmunoendocrine communication. Involvement on longevity	42
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review	40
Human astrocytes from healthy individuals and Alzheimer’s patients respond differently to Aβ1–42 oligomers, triggering distinct paths of reactivity and senescence	36
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe	36
Molecular mechanisms and potential interventions during aging-associated sarcopenia	34
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years	34
The role of mitochondria in cytokine and chemokine signalling during ageing	33
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways	31
Senescence of skeletal stem cells and their contribution to age-related bone loss	31
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl	31
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways	31
Editorial: Aging and osteoporosis	31
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	30

Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M	30
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity	30
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response	29
Decreased oxidative stress response and oxidant detoxification of skin during aging	29
Living in endemic area for infectious diseases accelerates epigenetic age	28
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role	28
Expression of concern: Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer’s disease	27
Vascular participation in bone healing: Implications related to advancing age and morbidity	27
Towards defining optimal concentrations of micronutrients in adults to optimize health	27
Inflammaging: The lesson of COVID-19 pandemic	26
Editorial Board	25
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease	25
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling	25
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging	25
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of	24
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]	23
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory	23
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox	23
A novel platform for precise senolysis	22
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder	22
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts	22
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus	21
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans	20
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project	20
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury	19
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses	18
The link between obesity and aging - insights into cardiac energy metabolism	18
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data	18
Improving intestinal inflammaging to delay aging? A new perspective	18
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?	18
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients	18
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age	17
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1	17
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?	17
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction	17
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections	17
Circulating mitokines GDF-15 and FGF21 are associated with frailty, sarcopenia, and malnutrition in older adults: Evidence from the FRASNET study	17
Editorial Board	16
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites	16
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila	16
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice	16
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6	15
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues	15
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]	15
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	15
Genistein, a tool for geroscience	15
Lipids and the hallmarks of ageing: From pathology to interventions	15
Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins	15
Editorial Board	14
Fecal microbiota transplantation holds the secret to youth	14

Senolytic drugs: Beyond the promise and the hype	14
EDITORIAL Special Issue: The influence of biological sex in ageing	14
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors	14
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment	14
Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids	14
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome	14
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy	14
Galectin-3-binding protein is a risk factor for diabetes, metabolic syndrome, and inflammation. Cross-sectional and longitudinal results from the InCHIANTI study	14
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus	14
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’	13
The emerging importance of lymphangiogenesis in aging and aging-associated diseases	13
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components	13
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology	13
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice	13
The influence of inflammation and frailty in the aging continuum	13
Single-cell analysis of human peripheral blood reveals high immune response activity in successful ageing individuals	12
Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology	12
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration	12
SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience	12
Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes	12
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4	12
Differential Plin5 response to high-fat diet in cardiomyocytes isolated from young and aged mice	12
Age-associated anatomical and physiological alterations in Caenorhabditis elegans	12
Cellular senescence and premature aging in Down Syndrome	12
miR-26a deficiency is associated with bone loss and reduced muscle strength but does not affect severity of cartilage damage in osteoarthritis	11
Role of stem cells in ageing and age-related diseases	11
Editorial Board	11
Inflammaging score as a potential prognostic tool for cancer: A population-based cohort study	11
Social environment improves the cytokine profile and lymphoproliferative response in chronologically old and prematurely aging mice	11
Counteracting aged DNA methylation states to combat ageing and age-related diseases	11
In the land of not-unhappiness: On the state-of-the-art of targeting aging and age-related diseases by biomedical research	11
Deuterated polyunsaturated fatty acids provided protection against oxidative stress in ocular fibroblasts derived from glaucoma patients	10
Editorial Board	10
Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice	10
Editorial Board	10
Do motoneuron discharge rates slow with aging? A systematic review and meta-analysis	10
Editorial Board	10
Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy	10
Editorial Board	10
Corrigendum to “Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6 J mice. A potential model of sporadic Alzheimer’s disease” [J. Mech. Agei	10
Editorial Board	10
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review	9
miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence	9
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases	9
Frailty and cytokines in preclinical models: Comparisons with humans	9
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice	9
The stress-responsive cytokine GDF-15 and sarcopenia: A systematic review and meta-analysis on aging muscle decline	9
Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation	9
Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts	9
HRasV12 induces apoptosis, not cellular senescence in mouse skeletal myoblasts	8
Energetic cost of biosynthesis modulates the growth-longevity tradeoff in mice: Quantitative insights into four lifespan-altering manipulations	8
Immunosenescence and COVID-19	8
Comparative analysis of fat composition in marrow, serum, and muscle from aging C57BL6 mice	8
The cGAS-STING signaling pathway is modulated by urolithin A	8
Plasma metabolomic profiles reveal sex-specific response to an oral glucose tolerance test in late middle-aged adults	8
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila	8
Interleukin-23 mediates the reduction of GADD45a expression to attenuate oxidative stress-induced cellular senescence in human fibroblasts	8
Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3	8
Relation of the kynurenine pathway with normal age: A systematic review	8
Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapy	8
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	7
Editorial Board	7
Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics	7
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	7
Navigating oligodendrocyte precursor cell aging in brain health	7
Common and distinct metabolomic markers related to immune aging in Western European and East African populations	7
Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP	7
Corrigendum to “Characterization of a natural model of adult mice with different rate of aging” [Mech. Ageing Dev. 222 (2024), 111991]	7
New frontiers in ageing and longevity: Sex and gender medicine	6
Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases	6
lncRNA EPB41L4A-AS1: A promising therapeutic target for aging and age-related diseases	6
An atlas of age- and sex-related volumetric alterations of grey matter in subcortical regions: The case of 46,111 UK Biobank participants	6
Fall of PARP3 restrains Lgr5+ intestinal stem cells proliferation and mucosal renovation in intestinal aging	6
Ashwagandha withanolides, Withaferin-A, and Withanone for natural interventions in aging and obesity	6
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway	6
Challenges of infectious diseases in older adults: From immunosenescence and inflammaging through antibiotic resistance to management strategies	6
Pan-tissue methylation aging clock: Recalibrated and a method to analyze and interpret the selected features	6
The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis	6
Sleep disorders and Alzheimer’s disease pathophysiology: The role of the Glymphatic System. A scoping review	6
Editorial Board	6

The role of NAD+ metabolism in macrophages in age-related macular degeneration	6
Editorial Board	6
Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis	6
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence	6
A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer’s disease, and improve its treatment	6
Current approaches of anti-age related diseases: From molecules up to whole organism	6
Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer’s disease	5
Understanding Alzheimer’s disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study	5
Role of cytokines and reactive oxygen species in brain aging	5
Aging: A struggle for beneficial to overcome negative factors made by muscle and bone	5
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy	5
Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols	5
Lack of activity of the mitochondrial large-conductance calcium-regulated potassium channels in senescent vascular smooth muscle cells.	5
Pathological implication of CaMKII in NF-κB pathway and SASP during cardiomyocytes senescence	5
Sex-dependent deterioration of cardiac function and molecular alterations in age- and disease-associated RAGE overexpression	5
Plasma cfDNA abundance as a prognostic biomarker for higher risk of death in geriatric cardiovascular patients	5
The damage-independent evolution of ageing by selective destruction	5
Increased mTOR signaling secondary to a human ILK missense variant inhibits nephrogenesis with decreased metabolism	5
The impact of opioids on the hallmarks of ageing	5
Editorial Board	5