Mechanisms of Ageing and Development

Article	Citations
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs	181
Characterization of a natural model of adult mice with different rate of aging	104
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	81
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice	77
Strategies for late phase preclinical and early clinical trials of senolytics	76
Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing	67
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study	61
The role of cytokines/chemokines in an aging skin immune microenvironment	57
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	56
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress	49
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT	49
Brain aging mechanisms with mechanical manifestations	44
Impact of age and gender on glioblastoma onset, progression, and management	42
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years	41
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases	40
Sex differences in neuroimmunoendocrine communication. Involvement on longevity	39
The role of mitochondria in cytokine and chemokine signalling during ageing	37
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review	37
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe	33
Mechanism of FTO-mediated m6A demethylation regulation of YAP1 in nucleus pulposus cell senescence	32
Molecular mechanisms and potential interventions during aging-associated sarcopenia	32
Editorial: Aging and osteoporosis	31
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways	30
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	29
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl	29

B cells from old mice induce the generation of inflammatory T cells through metabolic pathways	29
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity	29
Recent advances in the discovery of senolytics	28
Senescence of skeletal stem cells and their contribution to age-related bone loss	28
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response	27
Living in endemic area for infectious diseases accelerates epigenetic age	27
Vascular participation in bone healing: Implications related to advancing age and morbidity	27
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role	26
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease	26
Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M	26
Inflammaging: The lesson of COVID-19 pandemic	26
Decreased oxidative stress response and oxidant detoxification of skin during aging	26
Towards defining optimal concentrations of micronutrients in adults to optimize health	26
Expression of concern: Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer’s disease	26
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging	25
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of	24
Editorial Board	24
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling	24
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts	23
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory	23
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]	23
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury	23
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans	22
A novel platform for precise senolysis	22
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder	21
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox	21
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus	21
The link between obesity and aging - insights into cardiac energy metabolism	20
Improving intestinal inflammaging to delay aging? A new perspective	20
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project	20
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?	19
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses	19
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients	19
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites	18
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data	18
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections	17
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1	17
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age	17
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?	17
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila	17
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction	17
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue	17
Editorial Board	16
Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins	16
Lipids and the hallmarks of ageing: From pathology to interventions	16
Fatty acid desaturation is essential for C. elegans longevity at high temperature	16
Editorial Board	16
Genistein, a tool for geroscience	16
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	15
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice	15

Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6	15
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues	15
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors	14
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy	14
Editorial Board	14
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome	14
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]	14
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’	13
EDITORIAL Special Issue: The influence of biological sex in ageing	13
Fecal microbiota transplantation holds the secret to youth	13
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment	13
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus	13
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice	13
Senolytic drugs: Beyond the promise and the hype	13
Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids	12
Cellular senescence and premature aging in Down Syndrome	12
Galectin-3-binding protein is a risk factor for diabetes, metabolic syndrome, and inflammation. Cross-sectional and longitudinal results from the InCHIANTI study	12
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components	12
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration	12
The emerging importance of lymphangiogenesis in aging and aging-associated diseases	12
The influence of inflammation and frailty in the aging continuum	12
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology	12
The potential of Senolytics in transplantation	11
Differential Plin5 response to high-fat diet in cardiomyocytes isolated from young and aged mice	11
Age-associated anatomical and physiological alterations in Caenorhabditis elegans	11
SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience	11
A guide to senolytic intervention in neurodegenerative disease	11
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4	11
Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology	11
The tumor suppression theory of aging	11
Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes	11
Single-cell analysis of human peripheral blood reveals high immune response activity in successful ageing individuals	11
Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans	10
miR-26a deficiency is associated with bone loss and reduced muscle strength but does not affect severity of cartilage damage in osteoarthritis	10
Role of stem cells in ageing and age-related diseases	10
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions	10
Editorial Board	10
Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy	10
Social environment improves the cytokine profile and lymphoproliferative response in chronologically old and prematurely aging mice	10
Editorial Board	10
Deuterated polyunsaturated fatty acids provided protection against oxidative stress in ocular fibroblasts derived from glaucoma patients	10
Counteracting aged DNA methylation states to combat ageing and age-related diseases	10
Do motoneuron discharge rates slow with aging? A systematic review and meta-analysis	10
Inflammaging score as a potential prognostic tool for cancer: A population-based cohort study	10
In the land of not-unhappiness: On the state-of-the-art of targeting aging and age-related diseases by biomedical research	10
Corrigendum to “Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6 J mice. A potential model of sporadic Alzheimer’s disease” [J. Mech. Agei	9
Editorial Board	9
Editorial Board	9
Editorial Board	9
Frailty and cytokines in preclinical models: Comparisons with humans	9
Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice	8
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila	8
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases	8
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review	8
Plasma metabolomic profiles reveal sex-specific response to an oral glucose tolerance test in late middle-aged adults	8
Immunosenescence and COVID-19	8
Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation	8
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice	8
Energetic cost of biosynthesis modulates the growth-longevity tradeoff in mice: Quantitative insights into four lifespan-altering manipulations	8
Relation of the kynurenine pathway with normal age: A systematic review	8
Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts	8
miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence	8
Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapy	7
Common and distinct metabolomic markers related to immune aging in Western European and East African populations	7
Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics	7
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	7
HRasV12 induces apoptosis, not cellular senescence in mouse skeletal myoblasts	7
Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP	7
Comparative analysis of fat composition in marrow, serum, and muscle from aging C57BL6 mice	7
The cGAS-STING signaling pathway is modulated by urolithin A	7
Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3	7
Interleukin-23 mediates the reduction of GADD45a expression to attenuate oxidative stress-induced cellular senescence in human fibroblasts	7
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	7
Corrigendum to “Characterization of a natural model of adult mice with different rate of aging” [Mech. Ageing Dev. 222 (2024), 111991]	6
Challenges of infectious diseases in older adults: From immunosenescence and inflammaging through antibiotic resistance to management strategies	6
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway	6
Pan-tissue methylation aging clock: Recalibrated and a method to analyze and interpret the selected features	6
Editorial Board	6
Navigating oligodendrocyte precursor cell aging in brain health	6
Editorial Board	6

A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer’s disease, and improve its treatment	6
The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis	6
The role of NAD+ metabolism in macrophages in age-related macular degeneration	6
Sleep disorders and Alzheimer’s disease pathophysiology: The role of the Glymphatic System. A scoping review	6
New frontiers in ageing and longevity: Sex and gender medicine	6
Understanding Alzheimer’s disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study	5
Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases	5
The damage-independent evolution of ageing by selective destruction	5
Plasma cfDNA abundance as a prognostic biomarker for higher risk of death in geriatric cardiovascular patients	5
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy	5
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence	5
Editorial Board	5
Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer’s disease	5
Lack of activity of the mitochondrial large-conductance calcium-regulated potassium channels in senescent vascular smooth muscle cells.	5
Fall of PARP3 restrains Lgr5+ intestinal stem cells proliferation and mucosal renovation in intestinal aging	5
Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis	5
Current approaches of anti-age related diseases: From molecules up to whole organism	5