Mechanisms of Ageing and Development

Article	Citations
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice	155
Characterization of a natural model of adult mice with different rate of aging	109
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT	99
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs	97
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study	96
The role of cytokines/chemokines in an aging skin immune microenvironment	85
Strategies for late phase preclinical and early clinical trials of senolytics	80
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans	76
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	73
Impact of age and gender on glioblastoma onset, progression, and management	71
Brain aging mechanisms with mechanical manifestations	70
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	63
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress	59
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases	58
Editorial Board	53
Sex differences in neuroimmunoendocrine communication. Involvement on longevity	53
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years	52
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe	45
Molecular mechanisms and potential interventions during aging-associated sarcopenia	45
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints	44
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review	41
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways	39
The role of mitochondria in cytokine and chemokine signalling during ageing	39
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl	38
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways	38

Editorial: Aging and osteoporosis	37
Recent advances in the discovery of senolytics	36
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity	35
Senescence of skeletal stem cells and their contribution to age-related bone loss	35
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	34
Towards defining optimal concentrations of micronutrients in adults to optimize health	33
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role	33
Living in endemic area for infectious diseases accelerates epigenetic age	33
Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M	32
Decreased oxidative stress response and oxidant detoxification of skin during aging	31
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response	30
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling	28
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease	28
Vascular participation in bone healing: Implications related to advancing age and morbidity	28
Editorial Board	28
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging	27
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of	27
Inflammaging: The lesson of COVID-19 pandemic	27
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox	26
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder	26
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients	26
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]	26
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory	26
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury	26
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project	25
A novel platform for precise senolysis	25
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus	24
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans	24
Improving intestinal inflammaging to delay aging? A new perspective	24
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts	23
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives	23
The link between obesity and aging - insights into cardiac energy metabolism	23
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?	22
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses	22
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too	22
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites	22
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data	22
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1	22
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age	21
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction	20
Evaluation of senescent cells in intervertebral discs by lipofuscin staining	20
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?	20
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections	20
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila	19
Ferulic acid and hormesis: Biomedical and environmental implications	19
Editorial Board	19
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids	18
Editorial Board	18
Risks and rewards of targeting NAD+ homeostasis in the brain	17
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues	17

Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	17
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice	17
A quantile frailty index without dichotomization	17
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue	17
Genistein, a tool for geroscience	17
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors	16
Lipids and the hallmarks of ageing: From pathology to interventions	16
Editorial Board	16
Fatty acid desaturation is essential for C. elegans longevity at high temperature	16
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]	16
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy	16
Fecal microbiota transplantation holds the secret to youth	15
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology	15
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6	15
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome	15
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment	15
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components	14
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’	14
The role of senolytics in osteoporosis and other skeletal pathologies	14
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration	14
The influence of inflammation and frailty in the aging continuum	14
Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids	14
Senolytic drugs: Beyond the promise and the hype	13
Signs of diastolic dysfunction are graded by serum testosterone levels in aging C57BL/6 male mice	13
Cellular senescence and premature aging in Down Syndrome	13
EDITORIAL Special Issue: The influence of biological sex in ageing	13
The tumor suppression theory of aging	12
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus	12
Differential Plin5 response to high-fat diet in cardiomyocytes isolated from young and aged mice	12
Galectin-3-binding protein is a risk factor for diabetes, metabolic syndrome, and inflammation. Cross-sectional and longitudinal results from the InCHIANTI study	12
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4	12
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice	12
The emerging importance of lymphangiogenesis in aging and aging-associated diseases	12
Age-associated anatomical and physiological alterations in Caenorhabditis elegans	11
Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology	11
SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience	11
Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes	11
Single-cell analysis of human peripheral blood reveals high immune response activity in successful ageing individuals	11
Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy	10
In the land of not-unhappiness: On the state-of-the-art of targeting aging and age-related diseases by biomedical research	10
A guide to senolytic intervention in neurodegenerative disease	10
Role of stem cells in ageing and age-related diseases	10
Editorial Board	10
The potential of Senolytics in transplantation	10
Inflammaging score as a potential prognostic tool for cancer: A population-based cohort study	10
Social environment improves the cytokine profile and lymphoproliferative response in chronologically old and prematurely aging mice	10
Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans	9
Deuterated polyunsaturated fatty acids provided protection against oxidative stress in ocular fibroblasts derived from glaucoma patients	9
Editorial Board	9
miR-26a deficiency is associated with bone loss and reduced muscle strength but does not affect severity of cartilage damage in osteoarthritis	9
Counteracting aged DNA methylation states to combat ageing and age-related diseases	9
Editorial Board	9
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions	9
Editorial Board	9
Do motoneuron discharge rates slow with aging? A systematic review and meta-analysis	9
Ageing: Not only an age-related issue	8
Corrigendum to “Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6 J mice. A potential model of sporadic Alzheimer’s disease” [J. Mech. Agei	8
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases	8
Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapy	8
Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice	8
Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts	8
miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence	8
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review	8
Relation of the kynurenine pathway with normal age: A systematic review	8
Editorial Board	8
Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation	8
Frailty and cytokines in preclinical models: Comparisons with humans	8
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice	8
Energetic cost of biosynthesis modulates the growth-longevity tradeoff in mice: Quantitative insights into four lifespan-altering manipulations	8
The cGAS-STING signaling pathway is modulated by urolithin A	7
Plasma metabolomic profiles reveal sex-specific response to an oral glucose tolerance test in late middle-aged adults	7
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila	7
Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP	7
Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3	7
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology	7
Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia	7
Integration of miRNA’s theranostic potential with nanotechnology: Promises and challenges for Parkinson’s disease therapeutics	7
HRasV12 induces apoptosis, not cellular senescence in mouse skeletal myoblasts	7
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	7
New frontiers in ageing and longevity: Sex and gender medicine	7

Interleukin-23 mediates the reduction of GADD45a expression to attenuate oxidative stress-induced cellular senescence in human fibroblasts	7
Immunosenescence and COVID-19	7
Common and distinct metabolomic markers related to immune aging in Western European and East African populations	7
Comparative analysis of fat composition in marrow, serum, and muscle from aging C57BL6 mice	7
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	7
Corrigendum to “Characterization of a natural model of adult mice with different rate of aging” [Mech. Ageing Dev. 222 (2024), 111991]	6
Navigating oligodendrocyte precursor cell aging in brain health	6
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway	6
Pan-tissue methylation aging clock: Recalibrated and a method to analyze and interpret the selected features	6
A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer’s disease, and improve its treatment	6
The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis	6
Challenges of infectious diseases in older adults: From immunosenescence and inflammaging through antibiotic resistance to management strategies	6
Sleep disorders and Alzheimer’s disease pathophysiology: The role of the Glymphatic System. A scoping review	6
Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis	6
Editorial Board	6
Editorial Board	6
The role of NAD+ metabolism in macrophages in age-related macular degeneration	6
Sex differences in frailty: Comparisons between humans and preclinical models	6
Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases	6
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence	6
Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target	5
The damage-independent evolution of ageing by selective destruction	5
Pathological implication of CaMKII in NF-κB pathway and SASP during cardiomyocytes senescence	5
Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer’s disease	5
Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols	5
Lack of activity of the mitochondrial large-conductance calcium-regulated potassium channels in senescent vascular smooth muscle cells.	5
Current approaches of anti-age related diseases: From molecules up to whole organism	5
Plasma cfDNA abundance as a prognostic biomarker for higher risk of death in geriatric cardiovascular patients	5
Fall of PARP3 restrains Lgr5+ intestinal stem cells proliferation and mucosal renovation in intestinal aging	5
Editorial Board	5
Role of cytokines and reactive oxygen species in brain aging	5
Understanding Alzheimer’s disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study	5