OOIR: Observatory of International Research

Papers

(The TQCC of Mechanisms of Ageing and Development is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China	158
Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients	85
Neprilysin expression and functions in development, ageing and disease	84
TREM2, microglia, and Alzheimer’s disease	78
Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework	67
Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing	66
The conundrum of human immune system “senescence”	63
Brain aging mechanisms with mechanical manifestations	61
Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls	56
The complex interplay between depression and multimorbidity in late life: risks and pathways	55
Faces of cellular senescence in skin aging	55
Sex differences in frailty: Comparisons between humans and preclinical models	53
The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype	51
Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity	50
Strategies for late phase preclinical and early clinical trials of senolytics	50
Objectively assessed physical activity and sedentary behavior and global cognitive function in older adults: a systematic review	47
Recent advances in the discovery of senolytics	46
SIRT1 Regulation in Ageing and Obesity	44
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives	43
Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions	41
The role of cellular senescence in tissue repair and regeneration	39
Neuroinflammation in pathogenesis of Alzheimer’s disease: Phytochemicals as potential therapeutics	36
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview	36
Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging	36
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion	35

Immunosenescence and COVID-19	35
Coenzyme Q10 supplementation – In ageing and disease	34
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions	34
DNA methylation in Alzheimer’s disease: In brain and peripheral blood	34
Associations between diet and handgrip strength: a cross-sectional study from UK Biobank	33
The old guard: Age-related changes in microglia and their consequences	33
Senolytic targets and new strategies for clearing senescent cells	33
Female reproductive senescence across mammals: A high diversity of patterns modulated by life history and mating traits	31
The balance between NAD+ biosynthesis and consumption in ageing	31
Mitochondria and cellular redox state on the route from ageing to Alzheimer’s disease	30
Ferulic acid and hormesis: Biomedical and environmental implications	30
Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice	29
Age and Sex: Impact on adipose tissue metabolism and inflammation	29
Senotherapeutics: Targeting senescent cells for the main age-related diseases	28
Ageing as a risk factor for cerebral ischemia: Underlying mechanisms and therapy in animal models and in the clinic	28
Mechanisms of enhanced quiescence in neural stem cell aging	28
What if there’s no such thing as “aging”?	28
The environment as a determinant of successful aging or frailty	27
Aging Fits the Disease Criteria of the International Classification of Diseases	26
Hallmarks of aging Drosophila intestinal stem cells	26
The senescence-associated secretory phenotype: Fueling a wound that never heals	26
Protective effects of carotenoid fucoxanthin in fibroblasts cellular senescence	25
Untangling the complexity of multimorbidity with machine learning	25
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence	25
Cellular senescence in the aging brain: A promising target for neurodegenerative diseases	25
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding	24
The role of epigenetics and non-coding RNAs in autophagy: A new perspective for thorough understanding	24
Luteolin and hormesis	24
Sex differences in markers of oxidation and inflammation. Implications for ageing	23
Genome-wide profiling and predicted significance of post-mortem brain microRNA in Alzheimer’s disease	23
Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy	23
A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes	23
Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders	21
Specific features of the oldest old from the Longevity Blue Zones in Ikaria and Sardinia	21
ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy	21
The mechanism of lncRNA H19 in fibrosis and its potential as novel therapeutic target	21
The role of stem cell niche in intestinal aging	21
The role of senolytics in osteoporosis and other skeletal pathologies	20
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review	20
Erythrocytes as markers of oxidative stress related pathologies	20
tBHP treatment as a model for cellular senescence and pollution-induced skin aging	19
Aging, obese-insulin resistance, and bone remodeling	19
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence	19
A role for estrogen in skin ageing and dermal biomechanics	19
Targeting ER stress and calpain activation to reverse age-dependent mitochondrial damage in the heart	19
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology	19
Promises and challenges of senolytics in skin regeneration, pathology and ageing	18
Autophagy and heat-shock response impair stress granule assembly during cellular senescence	18
Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle	18
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells	18

Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints	18
The role of lipid-based signalling in wound healing and senescence	18
Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target	18
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans	18
A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials	17
Regulation of cellular senescence by microRNAs	17
Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin/IGF-1-like signaling in C. elegans	17
The Aging Imageomics Study: rationale, design and baseline characteristics of the study population	17
Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction	17
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy	17
Hyperbaric oxygen therapy restores cognitive function and hippocampal pathologies in both aging and aging-obese rats	17
Roles of OCT4 in pathways of embryonic development and cancer progression	17
Aging, calcium channel signaling and vascular tone	17
The role of physical exercise in modulating peripheral inflammatory and neurotrophic biomarkers in older adults: A systematic review and meta-analysis	17
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction	17
Routine laboratory parameters, including complete blood count, predict COVID-19 in-hospital mortality in geriatric patients	16
Stem cell aging: The upcoming era of proteins and metabolites	16
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model	16
Sestrin family – the stem controlling healthy ageing	16
Nifedipine-induced AMPK activation alleviates senescence by increasing autophagy and suppressing of Ca2+ levels in vascular smooth muscle cells	16
Associations of multimorbidity on frailty and dependence among an elderly rural population: Findings from the AHSETS study	16
Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults	16
Vascular ageing in hypertension: Focus on mitochondria	16
Frailty and cytokines in preclinical models: Comparisons with humans	16
Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells	15
Entropy modulation of electroencephalographic signals in physiological aging	15
Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype	15
Effects of cellular senescence on metabolic pathways in non-immune and immune cells	15
Malnutrition is associated with poor trajectories of activities of daily living in geriatric rehabilitation inpatients: RESORT	15
Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease	15
Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging	15
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	15
Connecting vascular aging and frailty in Alzheimer’s disease	15
Long-lived post-mitotic cell aging: is a telomere clock at play?	15
Frailty syndrome: A target for functional nutrients?	15
Facing multimorbidity in the precision medicine era	15
Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies	15
Gender-specific effects of pro-longevity interventions in Drosophila	14
Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults	14
Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system	14
CopA3 peptide induces permanent cell-cycle arrest in colorectal cancer cells	14
Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease	14
Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes	14
Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality	14