Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)
ArticleCitations
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs183
Characterization of a natural model of adult mice with different rate of aging108
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease81
Strategies for late phase preclinical and early clinical trials of senolytics78
Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing78
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT72
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice62
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress59
Impact of age and gender on glioblastoma onset, progression, and management58
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy54
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study51
Brain aging mechanisms with mechanical manifestations47
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases44
The role of cytokines/chemokines in an aging skin immune microenvironment44
Sex differences in neuroimmunoendocrine communication. Involvement on longevity42
Mechanism of FTO-mediated m6A demethylation regulation of YAP1 in nucleus pulposus cell senescence40
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review39
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe38
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years35
Molecular mechanisms and potential interventions during aging-associated sarcopenia34
The role of mitochondria in cytokine and chemokine signalling during ageing33
Editorial: Aging and osteoporosis31
Human astrocytes from healthy individuals and Alzheimer’s patients respond differently to Aβ1–42 oligomers, triggering distinct paths of reactivity and senescence31
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways31
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl31
Recent advances in the discovery of senolytics30
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis30
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity30
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways29
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response29
Senescence of skeletal stem cells and their contribution to age-related bone loss29
Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M29
Vascular participation in bone healing: Implications related to advancing age and morbidity28
Living in endemic area for infectious diseases accelerates epigenetic age28
Decreased oxidative stress response and oxidant detoxification of skin during aging28
Towards defining optimal concentrations of micronutrients in adults to optimize health28
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role27
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease27
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging26
Editorial Board26
Inflammaging: The lesson of COVID-19 pandemic26
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling26
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of25
Expression of concern: Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer’s disease25
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory24
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]24
The link between obesity and aging - insights into cardiac energy metabolism23
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder23
A novel platform for precise senolysis23
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans23
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project22
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus22
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox22
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury21
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients20
The TGF-β1-oxidative stress axis underlies accelerated senescence of endothelial cells exposed to serum from hypertensive patients20
Improving intestinal inflammaging to delay aging? A new perspective20
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts20
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses19
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data18
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?18
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections18
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction17
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age17
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila17
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?17
Circulating mitokines GDF-15 and FGF21 are associated with frailty, sarcopenia, and malnutrition in older adults: Evidence from the FRASNET study17
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 117
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites17
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice17
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue16
Lipids and the hallmarks of ageing: From pathology to interventions16
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder16
Editorial Board16
Editorial Board16
Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins15
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues15
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez615
Genistein, a tool for geroscience15
Fatty acid desaturation is essential for C. elegans longevity at high temperature15
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment14
Fecal microbiota transplantation holds the secret to youth14
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy14
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors14
Editorial Board14
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome14
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]14
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’13
Galectin-3-binding protein is a risk factor for diabetes, metabolic syndrome, and inflammation. Cross-sectional and longitudinal results from the InCHIANTI study13
Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids13
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology13
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus13
Senolytic drugs: Beyond the promise and the hype13
EDITORIAL Special Issue: The influence of biological sex in ageing13
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