Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1136
Potential protein biomarkers in saliva for detection of frailty syndrome by targeted proteomics125
Characterization of a natural model of adult mice with different rate of aging96
Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation83
Aging: A struggle for beneficial to overcome negative factors made by muscle and bone83
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses82
Editorial Board73
From cue to meaning: The involvement of POLD1 gene in DNA replication, repair and aging67
The sex-associated burden of atherosclerotic cardiovascular diseases: An update on prevention strategies66
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT63
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Sex-dependent deterioration of cardiac function and molecular alterations in age- and disease-associated RAGE overexpression58
Calcium transferring from ER to mitochondria via miR-129/ITPR2 axis controls cellular senescence in vitro and in vivo53
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model53
Ageing-induced hypercontractility is related to functional enhancement of STIM/Orai and upregulation of Orai 3 in rat and human penile tissue50
Editorial Board50
The role of cytokines/chemokines in an aging skin immune microenvironment49
The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop48
Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts47
Impact of ageing, fall history and exercise on postural reflexes following unpredictable perturbations: A systematic review and meta-analyses46
Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training43
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Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice37
Ageing: Not only an age-related issue37
Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease36
Sestrin2 plays a protective role in age-related hearing loss by inhibiting NLRP3-inflammasome activity36
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans35
Toward a multidisciplinary science of aging biology34
A blast from the past: To tame time with metformin34
No association between frailty index and epigenetic clocks in Italian semi-supercentenarians33
Ferulic acid and hormesis: Biomedical and environmental implications32
Rodent diet aids and the fallacy of caloric restriction31
Calorie restriction changes the anxiety-like behaviour of ageing male Wistar rats in an onset- and duration-dependent manner30
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study29
Impact of age and sex on hyperoxia-induced cardiovascular pathophysiology28
Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice28
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy28
Age-associated proinflammatory elastic fiber remodeling in large arteries27
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data27
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review27
Potential genetic biomarkers are found to be associated with both cognitive function and blood pressure: A bivariate genome-wide association analysis27
A new mechanistic insight into fate decisions during yeast cell aging process27
Adipose tissue senescence: Biological changes, hallmarks and therapeutic approaches26
The impact of opioids on the hallmarks of ageing26
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases26
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?26
Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances26
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age25
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites25
Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle25
Prenatal exposure to CB2 receptors agonist differentially impacts male and female germ cells via histone modification24
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too24
Corrigendum to “Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6 J mice. A potential model of sporadic Alzheimer’s disease” [J. Mech. Agei24
Brain aging mechanisms with mechanical manifestations23
Sirtuin 3 drives sex-specific responses to age-related changes in mouse embryonic fibroblasts23
Evaluation of senescent cells in intervertebral discs by lipofuscin staining22
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress22
Impact of age and gender on glioblastoma onset, progression, and management22
Strategies for late phase preclinical and early clinical trials of senolytics21
Supplementation with phosphatidylethanolamine confers anti-oxidant and anti-aging effects via hormesis and reduced insulin/IGF-1-like signaling in C. elegans21
Coenzyme Q10 supplementation – In ageing and disease21
Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice21
Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations20
Exploring the interplay between metabolomics and genetics in Parkinson's disease: Insights from ongoing research and future avenues20
RNA-binding proteins in cellular senescence20
Role and mechanism of TXNIP in ageing-related renal fibrosis20
Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic20
Frailty and cytokines in preclinical models: Comparisons with humans20
Sex and gender differences in Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis: A narrative review19
Aging – What it is and how to measure it19
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila18
Lipids and the hallmarks of ageing: From pathology to interventions18
The biological relevance of pigment epithelium-derived factor on the path from aging to age-related disease18
Editorial Board18
Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials18
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease18
The role of the LINC complex in ageing and microgravity18
Fatty acid desaturation is essential for C. elegans longevity at high temperature18
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases17
Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study17
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Preserving the discreteness of deficits during coding leads to a lower frailty index in individuals living in long-term care17
Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation17
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Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice16
Frailty syndrome: A target for functional nutrients?16
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Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes15
Novel 18-norspirostane steroidal saponins: Extending lifespan and mitigating neurodegeneration through promotion of mitophagy and mitochondrial biogenesis in Caenorhabditis elegans15
Relation of the kynurenine pathway with normal age: A systematic review15
What researchers on ageing should know about multimorbidity, geroprotectors and artificial intelligence15
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice15
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Elucidating the role of chemokines in inflammaging associated atherosclerotic cardiovascular diseases14
Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging14
Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells14
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder14
The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells14
Sex differences in neuroimmunoendocrine communication. Involvement on longevity14
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila14
A quantile frailty index without dichotomization14
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