Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)
ArticleCitations
Characterization of a natural model of adult mice with different rate of aging144
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study102
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT95
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice92
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy88
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans78
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease77
The role of cytokines/chemokines in an aging skin immune microenvironment69
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress68
Impact of age and gender on glioblastoma onset, progression, and management68
Coenzyme Q10 supplementation – In ageing and disease67
Brain aging mechanisms with mechanical manifestations61
Strategies for late phase preclinical and early clinical trials of senolytics59
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases56
Editorial Board54
Sex differences in neuroimmunoendocrine communication. Involvement on longevity52
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years51
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints51
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe51
The role of mitochondria in cytokine and chemokine signalling during ageing48
Molecular mechanisms and potential interventions during aging-associated sarcopenia43
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways39
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis38
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl38
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways37
Senescence of skeletal stem cells and their contribution to age-related bone loss37
Recent advances in the discovery of senolytics37
Vascular participation in bone healing: Implications related to advancing age and morbidity36
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity36
Decreased oxidative stress response and oxidant detoxification of skin during aging35
Editorial Board35
Living in endemic area for infectious diseases accelerates epigenetic age32
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role31
Towards defining optimal concentrations of micronutrients in adults to optimize health31
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response31
Inflammaging: The lesson of COVID-19 pandemic30
Editorial Board29
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of29
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling29
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease29
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients28
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans28
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]28
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory27
The link between obesity and aging - insights into cardiac energy metabolism26
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox26
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts26
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder26
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury26
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus26
A novel platform for precise senolysis25
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project25
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 124
Ferulic acid and hormesis: Biomedical and environmental implications24
Toward a multidisciplinary science of aging biology24
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives24
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses24
Improving intestinal inflammaging to delay aging? A new perspective24
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?23
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites23
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data23
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?22
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too22
Genistein, a tool for geroscience21
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila21
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction21
Editorial Board21
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age21
Editorial Board21
Evaluation of senescent cells in intervertebral discs by lipofuscin staining21
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues20
A quantile frailty index without dichotomization20
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids20
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice20
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue19
Risks and rewards of targeting NAD+ homeostasis in the brain19
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder19
Lipids and the hallmarks of ageing: From pathology to interventions18
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy18
Fatty acid desaturation is essential for C. elegans longevity at high temperature18
New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence18
Age-related activity of Poly (ADP-Ribose) Polymerase (PARP) in men with localized prostate cancer18
Caloric restriction enhances vascular tone of cerebral and mesenteric resistance arteries in aged rats17
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]17
Editorial Board17
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez617
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors17
Fecal microbiota transplantation holds the secret to youth16
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment16
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome16
Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology16
Cellular senescence in vascular wall mesenchymal stromal cells, a possible contribution to the development of aortic aneurysm16
The effect of physical exercise on functional brain network connectivity in older adults with and without cognitive impairment. A systematic review16
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’15
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus15
The role of senolytics in osteoporosis and other skeletal pathologies15
Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components15
Senotherapeutics: Targeting senescent cells for the main age-related diseases15
Senolytic drugs: Beyond the promise and the hype15
Signs of diastolic dysfunction are graded by serum testosterone levels in aging C57BL/6 male mice15
Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration15
EDITORIAL Special Issue: The influence of biological sex in ageing15
The emerging importance of lymphangiogenesis in aging and aging-associated diseases15
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