Xenobiotica

Article	Citations
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites	19
Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent d	18
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model	16
Developmental stage and infection status may affect drug distribution in the prostate of rats	12
Population pharmacokinetics of sirolimus in Chinese adult liver transplant recipients: a retrospective study	10
In vitro hepatic metabolism of the natural product quebecol	10
Diisononyl phthalate down-regulates the expression of antioxidant genes NFE2L2 , TXN , and TXNRD2 , while d	8
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	8
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	8
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	8
Academic foreign compound metabolism – ‘ quo vadis ’?	8
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics	7
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	7
Population pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients	7
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	7
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2	7
Formulation of apigenin-loaded solid lipid nanoparticles: characterisation, molecular docking, and anticancer assay	7
Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver	7
Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from p-tyramine	7
Oxidative metabolism of razuprotafib (AKB-9778), a sulfamic acid phosphatase inhibitor, in human microsomes and recombinant human CYP2C8 enzyme	7
Meeting report: oligonucleotide ADME workshop	7
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles in vitro	7
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	6
In vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin	6
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	6

Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	6
Arctigenin-induced erythrocyte membrane remodelling is mediated through calcium influx, metabolic collapse, and casein kinase 1α	6
Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats	6
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	6
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	6
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	6
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	6
Machine learning-driven bioavailability prediction in early-stage drug development: a KNIME-based computational workflow for digital health applications	6
Beyond cytotoxic potency: disposition features required to design ADC payload	6
Metabolic activation of zolmitriptan mediated by CYP2D6	6
Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity	6
Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes	6
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	6
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	6
New era in bioequivalence global harmonization through ICH M13 initiative: critical review on new concepts, alternative approaches for high-risk products	6
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod	6
Nano-pharmacokinetics and pharmacodynamics of green-synthesized ZnO nanoparticles: a pathway to safer therapeutic applications	5
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	5
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	5
Development of eugenol-fortified fisetin-loaded nano-invasomes gel	5
2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene	5
Pharmacokinetics and metabolic disposition of a potent and selective kynurenine monooxygenase inhibitor, CHDI-340246, in laboratory animals	5
Experimental and computational models to investigate intestinal drug permeability and metabolism	5
N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population	5
Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human	5
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats	5
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	5
Prediction of the neurotoxic mechanisms of the pesticide phorate using network toxicology, molecular docking, and molecular dynamics simulation	5
Bioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants	4
Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters	4
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective	4
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024	4
Sodium dodecylbenzene sulphonate (SDBS) present in detergents: action on the gills, skin, and blood of D. rerio fish	4
Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor	4
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection	4
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats	4
Sanguinarine-induced proteomic changes in methicillin-resistant Staphylococcus aureus	4
Effectiveness of pain care intervention combined with traditional Chinese medicine care in the perioperative care of patients with urinary stones	4
Preface for special issue: “Emerging strategies, technologies, and approaches for the next generation ADCs”	4
Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals?	4
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities	4
Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats	4
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	4
Inorganic mercury pharmacokinetics in man: a hybrid model	4
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor	4
The chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs	4
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities	4
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation	4
Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant	4
Defining the enzymes of xenobiotic metabolism – a forlorn hope?	4

Metabolism of gartanin in liver microsomes and its modulating effects on cytochrome P450s	4
Metabolic activation of deferiprone mediated by CYP2A6	4
Characterisation of seven medications approved for attention-deficit/hyperactivity disorder usingin vitromodels of hepatic metabolism	4
How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	4
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats	4
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)	4
Pharmacokinetics of intranasal drugs, still a missed opportunity?	4
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ after multi-dose in cynomolgus monkeys	4
Meeting report of the 3rd European Biotransformation Workshop	4
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species	4
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir	4
DEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells	4
Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats	3
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	3
EP300/HIF-1 pathway: the key to sacubitril valsartan sodium alleviating myocardial hypoxia injury	3
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects	3
Drug-drug interaction between danshensu and irbesartan and its potential mechanism	3
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans	3
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS	3
Feature-based molecular networking updates the in vitro metabolic characterisation of fenbendazole across species	3
Potential application of mass spectrometry imaging in pharmacokinetic studies	3
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism	3
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase	3
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	3
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	3
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats	3
Species differences in oxidative metabolism of regorafenib	3
Benzophenone-3 (oxybenzone) in zebrafish: histopathological and oxidative stress analysis	3
Study of the urinary metabolites of 17ɑ-methyl-19-nortestosterone in human using gas chromatography – mass spectrometry. Preliminary results	3
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	3
Investigation of pharmacokinetic properties of a PEGylated bilirubin nanoparticle in male Sprague-Dawley rats using liquid chromatography-quadrupole time-of-flight mass spectrometry	3
Bidirectional relationship between statins and the gut microbiota: implications for cardiovascular health, diabetes, and cancer	3
N, N -dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation	3
Thank you to reviewers	3
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes	3
Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma	3
Response to the comments raised by Fernando Tricta	3
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	3
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	3
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs	3
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models	3
Pharmacokinetics of chelerythrine and its metabolite after oral and intramuscular administrations in pigs	3
Prediction of pharmacokinetics of an anaplastic lymphoma kinase inhibitor in rat and monkey: application of physiologically based pharmacokinetic model as an alternative tool to minimise animal studie	2
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death	2
Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models	2
Quantitative prediction of OATP1B-mediated drug–drug interactions using endogenous biomarker coproporphyrin I	2
Meeting report: 3rd workshop of the peptide ADME discussion group	2
Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3	2
The in vivo disposition of subcutaneous injected 14C-razuprotafib (14C-AKB-9778), a sulphamic acid phosphatase inhibitor, in nonclinical species and human	2
Evaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling	2
Exposure to crack cocaine induces genotoxicity and degenerative changes in multiple organs of Wistar rats	2
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol	2
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022	2
Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay	2
Meeting report of the second European biotransformation workshop	2
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance	2
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders	2
Emerging conjugation strategies and protein engineering technologies aim to improve ADCs in the fight against cancer	2
The orexin 1-selective receptor antagonist nivasorexant is a time-dependent inhibitor of CYP2C19 and CYP3A4	2
The metabolism of the dual orexin receptor antagonist daridorexant	2
Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS	2
Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver	2
Metabolic conversion of β-pinene to β-ionone in rats	2
Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3	2
Preclinical pharmacokinetics, CYP phenotyping, and tissue distribution study of novel anti-breast cancer candidate S-011-1559	2
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans	2
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development	2
Justification of widened dissolution specifications of an extended-release product using physiologically based biopharmaceutics modeling	2
The pharmacokinetics of dabigatran in a rat model of hyperlipidaemia induced by poloxamer 407	2
Permethrin disrupts antioxidant defense responses in Litopenaeus vannamei .	2
Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases	2
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist	2
Dolutegravir metabolism: impact of genetic variations on uridine diphosphate glucuronosyltransferase subfamilies	2
Predictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy	2
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads	2
Exploring ethanol’s toxicity in the oral submucosa: chronic exposure versus abstinence in C57BL/6 mice	2
Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes	2
Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy	2
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs	2
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling	2

Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model	2
Effects of ABCG2 421C > A genetic polymorphism on the pharmacokinetics of rivaroxaban in healthy Chinese subjects	2
Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2	2
In silico analysis of nicotine’s molecular targets in Parkinson’s disease	2
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver	2
UGT1A1 and UGT1A3 activity and inhibition in human liver and intestinal microsomes and a recombinant UGT system under similar assay conditions using selective substrates and inhibitors	2
In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS	2
Metabolism and disposition of zamicastat in rats	2
Mechanism-based inactivation of cytochrome P450 3A by evodol	2
Preclinical pharmacokinetics, metabolism, and disposition of NXE0041178, a novel orally bioavailable agonist of the GPR52 receptor with potential for treatment of schizophrenia and related psychiatric	2
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and	2
Changes in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis	1
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations	1
Metabolic activation of aegeline mediated by CYP2C19	1
In vitro safety evaluation of (6-methoxy-9-oxo-9 H -xanthen-2-yl)methyl ( E )-3-(2,4-dimethoxyphenyl)acrylate (K-116) –	1
Hydrogen sulfide replenishment ameliorates impaired platelet response to clopidogrel in mice with experimental diabetes mellitus	1
Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity	1
Association of ABCG2 polymorphisms with susceptibility to anti-tuberculosis drug-induced hepatotoxicity in the Chinese population	1
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS	1
Development and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chines	1
Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans	1
CYP-catalysed cycling of clozapine and clozapine- N -oxide promotes the generation of reactive oxygen species in vitro	1
The in vitro metabolism and in vivo pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652	1
Combination of losartan and puerarin induced pharmacokinetic interaction in hypertension rats enhances the antihypertensive effect of losartan	1
Inhibition of YAP can down-regulate NLRP3 inflammasome and improve anti-tuberculosis drug-induced liver injury	1
In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1	1
Preclinical metabolism and disposition of [ 14 C]GFH009, a novel selective CDK9 inhibitor	1
4,4’-Methylene diphenyl diisocyanate exposure induces expression of alternatively activated macrophage-associated markers and chemokines partially through Krüppel-like factor 4 mediated signaling in m	1
Comparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant Staphylococcus aureus agents using a rat model of sepsis	1
Herb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa	1
Correction	1
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human	1
Optimising pirfenidone dosage regimens in idiopathic pulmonary fibrosis: towards a guide for personalised treatment	1
ADME properties of CHF6366, a novel bi-functional M3 muscarinic receptor antagonist and ß2 adrenoceptor agonist (MABA) radiolabelled at both functional moieties	1
Toxicokinetic and mass balance of morpholine in rats	1
Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research	1
Sex differences in the pharmacokinetics and tissue residues of Macleaya cordata extracts in rats	1
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients	1
Uptake of antiepileptic drugs in forskolin-induced differentiated BeWo cells: alteration of gabapentin transport	1
Crack cocaine exposure leads to developmental alterations and mitochondrial dysfunction in the Drosophila melanogaster model	1
Cytotoxic Effects of Flurbiprofen on Rat Adipose-Derived Stem Cells	1
Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla	1
Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis	1
Absorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants	1
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations	1
An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MSE	1
Meeting report of the 5th European Biotransformation Workshop	1
Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation	1
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets	1
Effect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes	1
Regulatory effect of atorvastatin combined with berberine on PI3K/AKT/FoxO1 signaling pathway in rats with hyperlipidaemia	1
Do differences in cell lines and methods used for calculation of IC50 values influence categorisation of drugs as P-glycoprotein substrates and inhibitors?	1
The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice	1
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers	1
Validation of population pharmacokinetic models: a comparison of internal and external validation approaches for hydrochlorothiazide	1
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies	1
Anastrozole and related glucuronic acid conjugate are electrophilic species	1
Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats	1
A general perspective for the conduct of radiolabelled distribution, metabolism, and excretion studies for antibody-drug conjugates	1
The 50th anniversary of the DMDG	1
Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review	1
Pharmacokinetics and tissue distribution of intranasal administration of rapamycin in rats	1
Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development	1
Population pharmacokinetics of mycophenolic acid and dose optimisation in adult Chinese kidney transplant recipients	1
Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13	1
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science	1
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model	1
Lung cell toxicity of co-exposure to airborne particulate matter and extremely low-frequency magnetic field	1
The metabolism of the orexin-1 selective receptor antagonist nivasorexant	1
Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies	1
Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans	1
Evaluation of MTBH, a novel hesperetin derivative, on the activity of hepatic cytochrome P450 isoform in vitro and in vivo using a cocktail method by HPLC-MS/MS	1
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers	1
Quantitative prediction of drug-drug interactions arising from CYP3A4 induction using chimeric mice with humanized liver	1
Assessment of cytochrome P450 induction in canine intestinal organoid models	1
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro	1
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR	1
MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophage	1
Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro	1
Clinical pharmacokinetics of cefixime: a systematic review	1
Pharmacokinetics of the novel 5-HT 4 receptor agonist, DA-6886, in dogs	1
Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A	1
The impact of ibuprofen on valproic acid plasma concentration in pediatric patients	1