Xenobiotica

Article	Citations
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites	19
Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent d	18
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model	15
Developmental stage and infection status may affect drug distribution in the prostate of rats	15
Population pharmacokinetics of sirolimus in Chinese adult liver transplant recipients: a retrospective study	14
In vitro hepatic metabolism of the natural product quebecol	12
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	10
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	10
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	10
Academic foreign compound metabolism – ‘ quo vadis ’?	9
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics	8
Oxidative metabolism of razuprotafib (AKB-9778), a sulfamic acid phosphatase inhibitor, in human microsomes and recombinant human CYP2C8 enzyme	8
Diisononyl phthalate down-regulates the expression of antioxidant genes NFE2L2 , TXN , and TXNRD2 , while d	8
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2	8
Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver	7
Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from p-tyramine	7
Metabolic activation of zolmitriptan mediated by CYP2D6	7
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	7
Population pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients	7
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	7
Meeting report: oligonucleotide ADME workshop	7
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles in vitro	7
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	6
Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity	6
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity	6

An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	6
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	6
Experimental and computational models to investigate intestinal drug permeability and metabolism	6
Metabolic activation of deferiprone mediated by CYP2A6	6
Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats	6
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod	6
Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes	6
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	6
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	6
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	6
Arctigenin-induced erythrocyte membrane remodeling is mediated through calcium influx, metabolic collapse, and casein kinase 1α	6
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats	6
Development of eugenol-fortified fisetin-loaded nano-invasomes gel	6
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	6
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	6
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	6
In vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin	6
Machine learning-driven bioavailability prediction in early-stage drug development: a KNIME-based computational workflow for digital health applications	6
Beyond cytotoxic potency: disposition features required to design ADC payload	6
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	6
Prediction of the neurotoxic mechanisms of the pesticide phorate using network toxicology, molecular docking, and molecular dynamics simulation	6
Metabolism of gartanin in liver microsomes and its modulating effects on cytochrome P450s	5
N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population	5
Pharmacokinetics and metabolic disposition of a potent and selective kynurenine monooxygenase inhibitor, CHDI-340246, in laboratory animals	5
2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene	5
Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters	5
Bioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants	5
Nano-pharmacokinetics and pharmacodynamics of green-synthesized ZnO nanoparticles: a pathway to safer therapeutic applications	5
Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals?	5
Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant	5
Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human	5
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	5
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	5
DEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells	5
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection	4
Pharmacokinetics of intranasal drugs, still a missed opportunity?	4
Characterisation of seven medications approved for attention-deficit/hyperactivity disorder usingin vitromodels of hepatic metabolism	4
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats	4
Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential a	4
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	4
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats	4
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)	4
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective	4
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities	4
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ after multi-dose in cynomolgus monkeys	4
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation	4
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities	4
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor	4
Response to the comments raised by Fernando Tricta	4
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	4

Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	4
Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor	4
How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	4
Sodium dodecylbenzene sulphonate (SDBS) present in detergents: action on the gills, skin, and blood of D. rerio fish	4
Effectiveness of pain care intervention combined with traditional Chinese medicine care in the perioperative care of patients with urinary stones	4
Preface for special issue: “Emerging strategies, technologies, and approaches for the next generation ADCs”	4
Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats	4
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats	4
The chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs	4
Species differences in oxidative metabolism of regorafenib	4
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024	4
Inorganic mercury pharmacokinetics in man: a hybrid model	4
In vivo-in vitrocorrelation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice	4
Meeting report of the 3rd European Biotransformation Workshop	4
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species	4
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir	4
N, N -dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation	3
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	3
Drug-drug interaction between danshensu and irbesartan and its potential mechanism	3
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes	3
Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma	3
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	3
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans	3
The metabolism of the dual orexin receptor antagonist daridorexant	3
Feature-based molecular networking updates the in vitro metabolic characterisation of fenbendazole across species	3
Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3	3
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism	3
Benzophenone-3 (oxybenzone) in zebrafish: histopathological and oxidative stress analysis	3
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs	3
Genetic polymorphism of Arg213His variant in the SULT1A1 gene is associated with reduced susceptibility to lung cancer in North Indian population	3
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	3
Study of the urinary metabolites of 17ɑ-methyl-19-nortestosterone in human using gas chromatography – mass spectrometry. Preliminary results	3
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	3
Potential application of mass spectrometry imaging in pharmacokinetic studies	3
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs	3
Investigation of pharmacokinetic properties of a PEGylated bilirubin nanoparticle in male Sprague-Dawley rats using liquid chromatography-quadrupole time-of-flight mass spectrometry	3
In vitro and in vivo evaluation of organic anion-transporting polypeptide 2B1-mediated pharmacokinetic interactions by apple polyphenols	3
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models	3
In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5′-diphospho-glucuronosyltransferase activity and expression	3
In vitro study of the drug–drug interaction potential of cetagliptin and clinical study of pharmacokinetic interaction of cetagliptin and metformin in healthy volunteers	3
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS	3
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects	3
Thank you to reviewers	3
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase	3
Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model	3
Pharmacokinetics of chelerythrine and its metabolite after oral and intramuscular administrations in pigs	3
Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats	3
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022	2
Metabolism and disposition of zamicastat in rats	2
Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver	2
Preclinical pharmacokinetics, CYP phenotyping, and tissue distribution study of novel anti-breast cancer candidate S-011-1559	2
Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy	2
Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies	2
Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats	2
Dolutegravir metabolism: impact of genetic variations on uridine diphosphate glucuronosyltransferase subfamilies	2
Justification of widened dissolution specifications of an extended-release product using physiologically based biopharmaceutics modeling	2
Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor	2
UGT1A1 and UGT1A3 activity and inhibition in human liver and intestinal microsomes and a recombinant UGT system under similar assay conditions using selective substrates and inhibitors	2
Evaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach	2
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development	2
Meeting report of the second European biotransformation workshop	2
Exploring ethanol’s toxicity in the oral submucosa: chronic exposure versus abstinence in C57BL/6 mice	2
Prediction of pharmacokinetics of an anaplastic lymphoma kinase inhibitor in rat and monkey: application of physiologically based pharmacokinetic model as an alternative tool to minimise animal studie	2
Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2	2
The in vivo disposition of subcutaneous injected 14C-razuprotafib (14C-AKB-9778), a sulphamic acid phosphatase inhibitor, in nonclinical species and human	2
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and	2
Meeting report: 3rd workshop of the peptide ADME discussion group	2
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver	2
Metabolic conversion of β-pinene to β-ionone in rats	2
Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation	2
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist	2
Evaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling	2
Mechanism-based inactivation of cytochrome P450 3A by evodol	2
The pharmacokinetics of dabigatran in a rat model of hyperlipidaemia induced by poloxamer 407	2
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans	2
Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay	2
Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS	2
S-Carboxymethyl-l-cysteine: a multiple dosing study using pharmacokinetic modelling	2
Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models	2
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling	2

Preclinical pharmacokinetics, metabolism, and disposition of NXE0041178, a novel orally bioavailable agonist of the GPR52 receptor with potential for treatment of schizophrenia and related psychiatric	2
Quantitative prediction of OATP1B-mediated drug–drug interactions using endogenous biomarker coproporphyrin I	2
Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes	2
In vitro study on the effect of leonurine hydrochloride on the enzyme activity of cytochrome P450 enzymes in human liver microsomes	2
Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3	2
Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase	2
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death	2
Combination of losartan and puerarin induced pharmacokinetic interaction in hypertension rats enhances the antihypertensive effect of losartan	2
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads	2
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol	2
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders	2
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance	2
Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo	2
Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases	2
Emerging conjugation strategies and protein engineering technologies aim to improve ADCs in the fight against cancer	2
Predictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy	2
In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS	2
The orexin 1-selective receptor antagonist nivasorexant is a time-dependent inhibitor of CYP2C19 and CYP3A4	2
Inhibition of YAP can down-regulate NLRP3 inflammasome and improve anti-tuberculosis drug-induced liver injury	1
A general perspective for the conduct of radiolabelled distribution, metabolism, and excretion studies for antibody-drug conjugates	1
Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research	1
Optimising pirfenidone dosage regimens in idiopathic pulmonary fibrosis: towards a guide for personalised treatment	1
Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development	1
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations	1
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients	1
Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla	1
Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis	1
In vitro safety evaluation of (6-methoxy-9-oxo-9 H -xanthen-2-yl)methyl ( E )-3-(2,4-dimethoxyphenyl)acrylate (K-116) –	1
Employing in vitro metabolism to guide design of F-labelled PET probes of novel α-synuclein binding bifunctional compounds	1
The metabolism of the orexin-1 selective receptor antagonist nivasorexant	1
Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR	1
The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice	1
In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1	1
4,4’-Methylene diphenyl diisocyanate exposure induces expression of alternatively activated macrophage-associated markers and chemokines partially through Krüppel-like factor 4 mediated signaling in m	1
MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophage	1
Regulatory effect of atorvastatin combined with berberine on PI3K/AKT/FoxO1 signaling pathway in rats with hyperlipidaemia	1
Clinical pharmacokinetics of cefixime: a systematic review	1
Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro	1
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model	1
ADME properties of CHF6366, a novel bi-functional M3 muscarinic receptor antagonist and ß2 adrenoceptor agonist (MABA) radiolabelled at both functional moieties	1
Evaluation of MTBH, a novel hesperetin derivative, on the activity of hepatic cytochrome P450 isoform in vitro and in vivo using a cocktail method by HPLC-MS/MS	1
Absorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants	1
Comparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant Staphylococcus aureus agents using a rat model of sepsis	1
Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies	1
Anastrozole and related glucuronic acid conjugate are electrophilic species	1
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers	1
Population pharmacokinetics of mycophenolic acid and dose optimisation in adult Chinese kidney transplant recipients	1
Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13	1
Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity	1
Association of ABCG2 polymorphisms with susceptibility to anti-tuberculosis drug-induced hepatotoxicity in the Chinese population	1
Sex differences in the pharmacokinetics and tissue residues of Macleaya cordata extracts in rats	1
Uptake of antiepileptic drugs in forskolin-induced differentiated BeWo cells: alteration of gabapentin transport	1
Toxicokinetic and mass balance of morpholine in rats	1
Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans	1
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR	1
Herb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa	1
The in vitro metabolism and in vivo pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652	1
CYP-catalysed cycling of clozapine and clozapine- N -oxide promotes the generation of reactive oxygen species in vitro	1
Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review	1
Metabolic activation of aegeline mediated by CYP2C19	1
The impact of ibuprofen on valproic acid plasma concentration in pediatric patients	1
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential ov	1
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies	1
Development and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chines	1
Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats	1
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets	1
Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A	1
Correction	1
Changes in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis	1
Effect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes	1
Preclinical metabolism and disposition of [ 14 C]GFH009, a novel selective CDK9 inhibitor	1
Validation of population pharmacokinetic models: a comparison of internal and external validation approaches for hydrochlorothiazide	1
Assessment of cytochrome P450 induction in canine intestinal organoid models	1
Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale	1
An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MSE	1
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS	1
Meeting report of the first European biotransformation workshop	1
The 50th anniversary of the DMDG	1
Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans	1
Interactions between cadmium and zinc on gene expression pattern of differentiation markers in MC3T3-E1 cell line	1
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers	1
An in silico investigation of the toxicological effects and biological activities of 3-phenoxybenzoic acid and its metabolite products	1
Lung cell toxicity of co-exposure to airborne particulate matter and extremely low-frequency magnetic field	1
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro	1
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations	1
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science	1
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human	1
Pharmacokinetics of the novel 5-HT 4 receptor agonist, DA-6886, in dogs	1
Do differences in cell lines and methods used for calculation of IC50 values influence categorisation of drugs as P-glycoprotein substrates and inhibitors?	1
Pharmacokinetics and tissue distribution of intranasal administration of rapamycin in rats	1
Meeting report of the 5th European Biotransformation Workshop	1