Xenobiotica

Article	Citations
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites	19
Formulation of apigenin-loaded solid lipid nanoparticles: characterisation, molecular docking, and anticancer assay	16
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	15
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	13
Academic foreign compound metabolism – ‘ quo vadis ’?	13
Developmental stage and infection status may affect drug distribution in the prostate of rats	11
In vitro hepatic metabolism of the natural product quebecol	10
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model	8
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics	8
Diisononyl phthalate down-regulates the expression of antioxidant genes NFE2L2 , TXN , and TXNRD2 , while d	8
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles in vitro	8
Apigenin Derivatives as Promising Norovirus RdRp Inhibitors: Insights from In Silico Docking and Molecular Dynamics Studies	8
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2	8
Population pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients	8
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	8
Meeting report: oligonucleotide ADME workshop	8
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	8
Methyl mercury pharmacokinetics in man: a five-compartment hybrid model	8
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	8
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	7
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	7
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	7
Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity	7
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	7
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod	7

Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats	7
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	7
Arctigenin-induced erythrocyte membrane remodelling is mediated through calcium influx, metabolic collapse, and casein kinase 1α	7
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	7
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	7
Machine learning-driven bioavailability prediction in early-stage drug development: a KNIME-based computational workflow for digital health applications	7
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	7
New era in bioequivalence global harmonization through ICH M13 initiative: critical review on new concepts, alternative approaches for high-risk products	7
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	6
Development of eugenol-fortified fisetin-loaded nano-invasomes gel	6
N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population	6
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	6
Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human	6
Prediction of the neurotoxic mechanisms of the pesticide phorate using network toxicology, molecular docking, and molecular dynamics simulation	6
Bioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants	6
Defining the enzymes of xenobiotic metabolism – a forlorn hope?	6
Mechanism of Black American Ginseng saponins in ameliorating memory dysfunction in aging mice by activating the BDNF/PI3K/AKT/CREB pathway	6
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	6
Experimental and computational models to investigate intestinal drug permeability and metabolism	6
In vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin	6
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats	6
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	6
Nano-pharmacokinetics and pharmacodynamics of green-synthesized ZnO nanoparticles: a pathway to safer therapeutic applications	6
Beyond cytotoxic potency: disposition features required to design ADC payload	6
2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene	6
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection	5
Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats	5
Pharmacokinetics of intranasal drugs, still a missed opportunity?	5
Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters	5
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation	5
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ after multi-dose in cynomolgus monkeys	5
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir	5
Sanguinarine-induced proteomic changes in methicillin-resistant Staphylococcus aureus	5
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective	5
Metabolism of gartanin in liver microsomes and its modulating effects on cytochrome P450s	5
Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant	5
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species	5
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities	5
Characterisation of seven medications approved for attention-deficit/hyperactivity disorder usingin vitromodels of hepatic metabolism	5
Meeting report of the 3rd European Biotransformation Workshop	5
Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals?	5
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats	5
Preface for special issue: “Emerging strategies, technologies, and approaches for the next generation ADCs”	5
Effectiveness of pain care intervention combined with traditional Chinese medicine care in the perioperative care of patients with urinary stones	5
How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	4
Study of the urinary metabolites of 17ɑ-methyl-19-nortestosterone in human using gas chromatography – mass spectrometry. Preliminary results	4
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes	4
EP300/HIF-1 pathway: the key to sacubitril valsartan sodium alleviating myocardial hypoxia injury	4
Drug-drug interaction between danshensu and irbesartan and its potential mechanism	4
Use of a machine learning approach to estimate pathobiological effects of crack cocaine administration in rats	4

Response to the comments raised by Fernando Tricta	4
Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor	4
The chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs	4
Sodium dodecylbenzene sulphonate (SDBS) present in detergents: action on the gills, skin, and blood of D. rerio fish	4
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)	4
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats	4
Calycosin improves insulin resistance by regulating the hsa-miR-324-3p/AKT pathway to inhibit FOXO3a nuclear transfer	4
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS	4
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects	4
Studies addressing potential bioactivation and genotoxicity liabilities of the N -nitroso derivative of the antidepressant paroxetine	4
Inorganic mercury pharmacokinetics in man: a hybrid model	4
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	4
Physiologically based pharmacokinetic (PBPK) modelling and simulation based integrative approach to assess natural product-drug interactions – effect of glycyrrhetinic acid on quetiapine	4
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	4
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities	4
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor	4
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs	4
Green Synthesis of Zinc Oxide Nanoflowers Using Camellia sinensis Extract and Evaluation of Their Xenobiotic-Like Cellular, Apoptotic, and Inflammatory R	4
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	4
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats	4
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	4
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	4
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	4
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024	4
Investigation of pharmacokinetic properties of a PEGylated bilirubin nanoparticle in male Sprague-Dawley rats using liquid chromatography-quadrupole time-of-flight mass spectrometry	3
Preclinical pharmacokinetics, CYP phenotyping, and tissue distribution study of novel anti-breast cancer candidate S-011-1559	3
Analysis of the therapeutic potential of astragalin: insights into target interactions and mechanisms	3
Permethrin disrupts antioxidant defense responses in Litopenaeus vannamei	3
In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS	3
Unravelling the toxic potential of imidacloprid and chlorothalonil in thyroid, liver, and kidney of rats: a combined experimental and computational investigations	3
Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats	3
Thank you to reviewers	3
Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma	3
N, N -dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation	3
Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver	3
The metabolism of the dual orexin receptor antagonist daridorexant	3
Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models	3
Prediction of pharmacokinetics of an anaplastic lymphoma kinase inhibitor in rat and monkey: application of physiologically based pharmacokinetic model as an alternative tool to minimise animal studie	3
Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model	3
Potential application of mass spectrometry imaging in pharmacokinetic studies	3
Bidirectional relationship between statins and the gut microbiota: implications for cardiovascular health, diabetes, and cancer	3
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism	3
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	3
Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3	3
Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3	3
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022	3
Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes	3
Preclinical pharmacokinetics, metabolism, and disposition of NXE0041178, a novel orally bioavailable agonist of the GPR52 receptor with potential for treatment of schizophrenia and related psychiatric	3
Feature-based molecular networking updates the in vitro metabolic characterisation of fenbendazole across species	3
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models	3
Benzophenone-3 (oxybenzone) in zebrafish: histopathological and oxidative stress analysis	3
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans	3
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs	3
Predictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy	2
Combination of losartan and puerarin induced pharmacokinetic interaction in hypertension rats enhances the antihypertensive effect of losartan	2
Exposure to crack cocaine induces genotoxicity and degenerative changes in multiple organs of Wistar rats	2
In silico analysis of nicotine’s molecular targets in Parkinson’s disease	2
Exploring ethanol’s toxicity in the oral submucosa: chronic exposure versus abstinence in C57BL/6 mice	2
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol	2
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling	2
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death	2
Mass balance and metabolite profiling of 14 C-Zalunfiban in humans following single-dose subcutaneous administration	2
Mechanism-based inactivation of cytochrome P450 3A by evodol	2
Emerging conjugation strategies and protein engineering technologies aim to improve ADCs in the fight against cancer	2
Meeting report of the second European biotransformation workshop	2
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver	2
Metabolism and disposition of zamicastat in rats	2
The 50th anniversary of the DMDG	2
Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay	2
The pharmacokinetics of dabigatran in a rat model of hyperlipidaemia induced by poloxamer 407	2
Justification of widened dissolution specifications of an extended-release product using physiologically based biopharmaceutics modeling	2
Quantitative prediction of OATP1B-mediated drug–drug interactions using endogenous biomarker coproporphyrin I	2
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and	2
Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy	2
Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS	2
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development	2
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads	2
Dolutegravir metabolism: impact of genetic variations on uridine diphosphate glucuronosyltransferase subfamilies	2
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist	2
Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2	2

CYP-catalysed cycling of clozapine and clozapine- N -oxide promotes the generation of reactive oxygen species in vitro	2
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro	2
Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases	2
Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation	2
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance	2
Fluoxetine as an antidepressant agent induces directly deleterious effects on rat isolated pancreatic mitochondria: ameliorative role of betanin	2
The orexin 1-selective receptor antagonist nivasorexant is a time-dependent inhibitor of CYP2C19 and CYP3A4	2
In vitro anti-glucocorticoid osteoporosis effect of Serfurosterone A and its intestinal absorption characteristics	2
Evaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling	2
Effects of ABCG2 421C > A genetic polymorphism on the pharmacokinetics of rivaroxaban in healthy Chinese subjects	2
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders	2
MRM-driven metabolomic workflow for early detection of antibiotic-triggered sub-lethal toxicity using Q-TRAP and zebrafish model	2
In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1	2