Xenobiotica

Article	Citations
Mechanism-based inactivation of cytochrome P450 3A by evodol	25
Intracellular activation of 4-hydroxycyclophosphamide into a DNA-alkylating agent in human leucocytes	16
Oxidative metabolism of razuprotafib (AKB-9778), a sulfamic acid phosphatase inhibitor, in human microsomes and recombinant human CYP2C8 enzyme	15
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	15
Dolutegravir metabolism: impact of genetic variations on uridine diphosphate glucuronosyltransferase subfamilies	15
Inorganic mercury pharmacokinetics in man: a hybrid model	12
Effects of CYP3A5 polymorphism and renal impairment on the drug interaction between venetoclax and fluconazole in acute myeloid leukaemia patients	12
In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS	11
Optimising pirfenidone dosage regimens in idiopathic pulmonary fibrosis: towards a guide for personalised treatment	11
Identification of in vivo metabolites of a potential anti-rheumatoid arthritis compound, the quinazolinone derivative PD110, using ultra-high performance liquid chromatography coupled with Q-Exactive	9
Meeting report of the second European biotransformation workshop	9
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2	9
Development of a physiologically based pharmacokinetic model for levetiracetam in patients with renal impairment to guide dose adjustment based on steady-state peak/trough concentrations	8
A general perspective for the conduct of radiolabelled distribution, metabolism, and excretion studies for antibody-drug conjugates	8
Emerging conjugation strategies and protein engineering technologies aim to improve ADCs in the fight against cancer	8
Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa	7
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	7
Meeting report: oligonucleotide ADME workshop	7
Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase	7
In vivo-in vitrocorrelation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice	7
Human keratinocyte response to 4,4’-methylene diphenyl diisocyanate-glutathione conjugate exposure	7
Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A	7
Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders	7
Toxicokinetic and mass balance of morpholine in rats	7
Anastrozole and related glucuronic acid conjugate are electrophilic species	6

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [ 14 C]aficamten following single oral dose administration to rats	6
Metabolism, pharmacokinetics and excretion of [14C]dimethyl fumarate in healthy volunteers: an example of xenobiotic biotransformation following endogenous metabolic pathways	6
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans	6
Pomegranate peel polyphenols interaction with intestinal flora and its metabolic transformation	6
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model	6
Pharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model	6
A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs	6
Sex differences in the pharmacokinetics and tissue residues of Macleaya cordata extracts in rats	6
Population pharmacokinetics of sirolimus in Chinese adult liver transplant recipients: a retrospective study	6
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	6
A systematic review of allometric scaling exponents for IgG mAbs	6
Changes in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis	6
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	6
Roles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes	6
Evaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach	5
Use of stable isotope labeled (SIL) antibodies in cassette dosing to improve pharmacokinetics screening efficiency of ADCs with novel cytotoxic payloads	5
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist	5
Absorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs	5
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics	5
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	5
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor	5
Vaginal administration of 17-alpha hydroxyprogesterone caproate appears to be safe in non-pregnant female rats and rabbits	5
Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity in vitro	5
Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor	5
Assessment of P-glycoprotein function using canine intestinal organoid-derived epithelial interfaces	5
Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent d	5
The common indoor air pollutant α-pinene is metabolised to a genotoxic metabolite α-pinene oxide	5
Developmental stage and infection status may affect drug distribution in the prostate of rats	5
In vitro hepatic metabolism of the natural product quebecol	5
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites	5
Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo	4
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	4
Curcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment	4
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	4
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science	4
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)	4
Comparison between lab variability andin silicoprediction errors for the unbound fraction of drugs in human plasma	4
Clinical pharmacokinetics of cefixime: a systematic review	4
Evaluation of MTBH, a novel hesperetin derivative, on the activity of hepatic cytochrome P450 isoform in vitro and in vivo using a cocktail method by HPLC-MS/MS	4
Thank you to reviewers	4
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans	4
Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor	4
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats	4
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	4
In vitro inhibition and induction of human liver cytochrome P450 enzymes by a novel anti-fibrotic drug fluorofenidone	4
Predicting routes of phase I and II metabolism based on quantum mechanics and machine learning	4
Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats	4
Effects of benzophenone-3 on the liver and thyroid of adult zebrafish	4
Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia	4
Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from p-tyramine	4

Species differences in oxidative metabolism of regorafenib	4
Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children	4
Hypothesis of using albumin to improve drug efficacy in cancers accompanied by hypoalbuminemia	4
Absorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants	4
Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats	4
Academic foreign compound metabolism – ‘ quo vadis ’?	4
How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	4
Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR	4
Metabolism of the antipsychotic drug olanzapine by CYP3A43	4
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles in vitro	4
Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver	4
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats	3
Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research	3
Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale	3
Prediction of human serum concentration–time profiles of therapeutic monoclonal antibodies using common marmosets ( Callithrix jacchus ): initial assessment with canakin	3
Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats	3
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity	3
Population pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients	3
Effect of formulation and route of administration on the distribution of 17-hydroxyprogesterone caproate in rats	3
Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity	3
Bioanalytical approaches to support the development of antibody-oligonucleotide conjugate (AOC) therapeutic proteins	3
Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats	3
Quantitative prediction of OATP1B-mediated drug–drug interactions using endogenous biomarker coproporphyrin I	3
Response to the comments raised by Fernando Tricta	3
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	3
Herb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa	3
Improved preclinical drug metabolism and pharmacokinetics of pibothiadine (HEC121210), a novel hepatitis B virus capsid assembly modulator	3
Validation of population pharmacokinetic models: a comparison of internal and external validation approaches for hydrochlorothiazide	3
Diurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice	3
In vitro ADME, mouse pharmacokinetics of LD14b, and bioanalysis of a novel aβ 17β-HSD10 modulator for the treatment of Alzheimer’s disease	3
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations	3
ADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs)	3
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death	3
Pharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys	3
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver	3
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes	3
Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS	3
Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy	3
Metabolic activation of zolmitriptan mediated by CYP2D6	3
Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes	2
Development and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chines	2
Predictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy	2
Untargeted metabolomics-assisted comparative cytochrome P450-dependent metabolism of fenbendazole in human and dog liver microsomes	2
Evaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling	2
Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies	2
A commentary on the use of pharmacoenhancers in the pharmaceutical industry and the implication for DMPK drug discovery strategies	2
Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2	2
In vitro safety evaluation of (6-methoxy-9-oxo-9 H -xanthen-2-yl)methyl ( E )-3-(2,4-dimethoxyphenyl)acrylate (K-116) –	2
Absorption, distribution, metabolism and excretion of 14 C-vatiquinone in rats, dogs, and human subjects	2
Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling	2
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	2
In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5′-diphospho-glucuronosyltransferase activity and expression	2
Metabolic conversion of β-pinene to β-ionone in rats	2
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	2
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	2
In vitro study of the drug–drug interaction potential of cetagliptin and clinical study of pharmacokinetic interaction of cetagliptin and metformin in healthy volunteers	2
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K	2
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS	2
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes	2
In vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin	2
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential ov	2
Effect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes	2
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	2
Population pharmacokinetics of mycophenolic acid and dose optimisation in adult Chinese kidney transplant recipients	2
In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice	2
Exploring the pharmacokinetics of second-generation cephalosporin, cefaclor: a systematic review in healthy and diseased populations	2
Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity	2
Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats	2
Thank you to reviewers	2
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs	2
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod	2
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects	2
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	2
S-Carboxymethyl-l-cysteine: a multiple dosing study using pharmacokinetic modelling	2
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	2
Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma	2
Inhibition of ABC transporters by sorafenib and lenvatinib: implications for drug-induced cholestasis	2
Cadmium-induced preeclampsia-like phenotype in the rat is related to decreased progesterone synthesis in the placenta	2
In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes	2
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS	2

Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla	2
Pharmacokinetics of levonorgestrel and etonogestrel in rat or minipig following intravenous, subcutaneous, or intradermal administration	2
Drug-drug interaction between danshensu and irbesartan and its potential mechanism	2
Pharmacokinetics and pharmacodynamic interaction of bergamottin with atorvastatin in rats	2
Do differences in cell lines and methods used for calculation of IC50 values influence categorisation of drugs as P-glycoprotein substrates and inhibitors?	2
Species and tissue differences in regorafenib glucuronidation	2
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets	2
Time matters – in vitro cellular disposition kinetics help rationalizing cellular potency disconnects	2
Genetic polymorphism of Arg213His variant in the SULT1A1 gene is associated with reduced susceptibility to lung cancer in North Indian population	2
Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines	2
Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay	1
In silico ADME/tox comes of age: twenty years later	1
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	1
Metabolism and disposition of zamicastat in rats	1
N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population	1
Experimental and computational models to investigate intestinal drug permeability and metabolism	1
Agrimoniin inhibits the activity of CYP1A2, 2D6, and 3A4 in human liver microsomes	1
Uptake of antiepileptic drugs in forskolin-induced differentiated BeWo cells: alteration of gabapentin transport	1
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity	1
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	1
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase	1
Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human	1
In vitro and in vivo evaluation of organic anion-transporting polypeptide 2B1-mediated pharmacokinetic interactions by apple polyphenols	1
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development	1
Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats	1
2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene	1
Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development	1
The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice	1
Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients	1
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	1
Beyond cytotoxic potency: disposition features required to design ADC payload	1
Metal-metal interaction and metal toxicity: a comparison between mammalian and D. melanogaster	1
The metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C] cetagliptin in healthy volunteers	1
Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model	1
mRNA expression levels of cytochrome P450 CYP1A2 , CYP3A4 , and CYP3A5 in the epidermis: a focus on individ	1
Xenobiotica Special Edition Preface	1
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	1
In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models	1
Human pharmacokinetics prediction with an in vitro–in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer	1
Interactions between cadmium and zinc on gene expression pattern of differentiation markers in MC3T3-E1 cell line	1
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	1
Pharmacokinetics and metabolic disposition of a potent and selective kynurenine monooxygenase inhibitor, CHDI-340246, in laboratory animals	1
Bioavailability, safety and tolerability of intravenous brivaracetam in healthy Japanese participants	1
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism	1
Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats	1
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models	1
Thank you to reviewers	1
Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases	1
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR	1
Simultaneous determination of four phytoecdysteroids by LC-MS/MS: application to a comparative pharmacokinetic study in normal and adjuvant arthritis rats after oral administration of C	1
In vitro drug-drug interactions of decitabine and tetrahydrouridine involving drug transporters and drug metabolising enzymes	1
Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes	1
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	1
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol	1
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human	1
Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers	1
The metabolite profiling of YR-1702 injection in human plasma, urine and feces by HPLC-Q-TOF-MS/MS	1
In vitro study on the effect of leonurine hydrochloride on the enzyme activity of cytochrome P450 enzymes in human liver microsomes	1
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	1
Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism	1
Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13	1
N, N -dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation	1
Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes	1
Disposition study of the novel dipeptidyl peptidase 4 inhibitor cetagliptin in rats	1
Study on pharmacokinetics and tissue distribution of deoxypodophyllotoxin and its metabolites in tumour-bearing mice	1
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	1
Potential application of mass spectrometry imaging in pharmacokinetic studies	1
Novel omeprazole delayed release orally disintegrating tablets for enhanced patient compliance: a case of model informed formulation development	1
UGT1A1 and UGT1A3 activity and inhibition in human liver and intestinal microsomes and a recombinant UGT system under similar assay conditions using selective substrates and inhibitors	1
In vitro evaluation of intestinal absorption of tiliroside from Edgeworthia gardneri (Wall.) Meisn.	1
Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review	1
Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans	1
MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophage	1
Preclinical metabolism and disposition of [ 14 C]GFH009, a novel selective CDK9 inhibitor	1
Metabolic activation of aegeline mediated by CYP2C19	1
Pharmacokinetics and mass balance of vericiguat in rats and dogs and distribution in rats	1
Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats	1
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and	1