OOIR: Observatory of International Research

Papers

(The TQCC of Xenobiotica is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development	24
Academic foreign compound metabolism – ‘ quo vadis ’?	23
In vitro hepatic metabolism of the natural product quebecol	19
Meeting report: oligonucleotide ADME workshop	16
Diisononyl phthalate down-regulates the expression of antioxidant genes NFE2L2 , TXN , and TXNRD2 , while d	14
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver	13
Nrf2 signaling pathway studies in Drosophila melanogaster : parallel roles in human health and insect environmental responses	12
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor	12
Formaldehyde directly induces cytotoxicity in human lymphocytes through ROS formation, mitochondrial/lysosomal destruction and oxidative stress; analysis of the protective effects of crocin	11
An In silico model-based feasibility assessment of erlotinib long-acting injectable formulation for the management of metastatic non-small cell lung cancer	11
Apigenin derivatives as promising norovirus RdRp inhibitors: insights from in silico docking and molecular dynamics studies	10
Formulation of apigenin-loaded solid lipid nanoparticles: characterisation, molecular docking, and anticancer assay	10
Developmental stage and infection status may affect drug distribution in the prostate of rats	10
The protective effect of linalool against carbon tetrachloride-induced testicular toxicity in rats	10
Methyl mercury pharmacokinetics in man: a five-compartment hybrid model	9
Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions	9
Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences	9
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain	9
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells	8
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers	8
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle	8
Arctigenin-induced erythrocyte membrane remodelling is mediated through calcium influx, metabolic collapse, and casein kinase 1α	8
Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P ₁ modulator ponesimod	8
Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 1 and 2 (rs4244285, 681G>A) alleles in vitro	8
New era in bioequivalence global harmonization through ICH M13 initiative: critical review on new concepts, alternative approaches for high-risk products	8

Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats	7
Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation	7
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds	7
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A2	7
Steady-state pharmacokinetics of oral semaglutide using semi-mechanistic pharmacokinetic modelling and population simulations	7
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics	7
Mechanism of Black American Ginseng saponins in ameliorating memory dysfunction in aging mice by activating the BDNF/PI3K/AKT/CREB pathway	7
Defining the enzymes of xenobiotic metabolism – a forlorn hope?	7
Machine learning-driven bioavailability prediction in early-stage drug development: a KNIME-based computational workflow for digital health applications	7
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-M	7
Tetrahydrouridine pre-treatment increases tissue exposure of ¹⁴ C-decitabine in mice	6
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma	6
Development of eugenol-fortified fisetin-loaded nano-invasomes gel	6
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation	6
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir	6
Effectiveness of pain care intervention combined with traditional Chinese medicine care in the perioperative care of patients with urinary stones	6
Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human	6
Experimental and computational models to investigate intestinal drug permeability and metabolism	6
Beyond cytotoxic potency: disposition features required to design ADC payload	6
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats	6
Nano-pharmacokinetics and pharmacodynamics of green-synthesized ZnO nanoparticles: a pathway to safer therapeutic applications	6
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study	6
Prediction of the neurotoxic mechanisms of the pesticide phorate using network toxicology, molecular docking, and molecular dynamics simulation	6
Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant	6
Preface for special issue: “Emerging strategies, technologies, and approaches for the next generation ADCs”	6
Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ after multi-dose in cynomolgus monkeys	6
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective	5
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities	5
Human and nonclinical disposition of [¹⁴C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection	5
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species	5
Sodium dodecylbenzene sulphonate (SDBS) present in detergents: action on the gills, skin, and blood of D. rerio fish	5
Exploring the clinical pharmacokinetics and pharmacodynamics of third-generation cephalosporin, a cefotaxime: a systematic review	5
Meeting report of the 3rd European Biotransformation Workshop	5
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities	5
Sanguinarine-induced proteomic changes in methicillin-resistant Staphylococcus aureus	5
Preparation of berberine micelles and its anti-skin damage in hyperglycemia mice	5
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2024	4
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate	4
Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury	4
Use of a machine learning approach to estimate pathobiological effects of crack cocaine administration in rats	4
The mitochondrial protective mechanisms mediated by SGLT2i: from molecular basis to clinical implications	4
The impact of CYP3A5 , NR1I2 , and POR polymorphisms on tacrolimus dose-adjusted concentration and clinical	4
An LC-MS/MS method for simultaneous quantification of six components of Angelicae pubescentis radix and systematic evaluation of A	4
Pharmacokinetics of intranasal drugs, still a missed opportunity?	4
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration	4
Inorganic mercury pharmacokinetics in man: a hybrid model	4
Perspectives on the use of machine learning for ADME prediction at AstraZeneca	4
Study of the urinary metabolites of 17ɑ-methyl-19-nortestosterone in human using gas chromatography – mass spectrometry. Preliminary results	4
Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up	4
How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data	4

Physiologically based pharmacokinetic (PBPK) modelling and simulation based integrative approach to assess natural product-drug interactions – effect of glycyrrhetinic acid on quetiapine	4
In vitro evaluation of norwogonin as a potential inhibitor of cytochrome P450 forms 3A4, 2D6, and 2C9	4
Drug-drug interaction between danshensu and irbesartan and its potential mechanism	4
Studies addressing potential bioactivation and genotoxicity liabilities of the N -nitroso derivative of the antidepressant paroxetine	4
EP300/HIF-1 pathway: the key to sacubitril valsartan sodium alleviating myocardial hypoxia injury	4