OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Biochemistry is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Preparing Better Samples for Cryo–Electron Microscopy: Biochemical Challenges Do Not End with Isolation and Purification	305
Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis	191
Repair of DNA Breaks by Break-Induced Replication	177
The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA–Protein Condensates	136
Emerging Approaches for Studying Lipid Dynamics, Metabolism, and Interactions in Cells	134
Lipid Dynamics at Membrane Contact Sites	116
The Initiation of Eukaryotic DNA Replication	115
Chaperoning SNARE Folding and Assembly	102
Moonlighting Enzymes at the Interface Between Metabolism and Epigenetics	100
The Structural Dynamics of Translation	97
The Purinosome: A Case Study for a Mammalian Metabolon	92
Mitochondrial DNA Release in Innate Immune Signaling	90
Synonymous but Not Silent: The Codon Usage Code for Gene Expression and Protein Folding	89
Mechanisms of General Anesthesia	88
Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol	87
Membrane Exporters of Fluoride Ion	87
The Form and Function of PIEZO2	86
The Inseparable Relationship Between Cholesterol and Hedgehog Signaling	84
Signaling from RAS to RAF: The Molecules and Their Mechanisms	77
Mechanisms of Vertebrate DNA Interstrand Cross-Link Repair	71
Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily	71
From Bioorganic Models to Cells	69
Short- and Long-Term Adaptation to Altered Levels of Glucose: Fifty Years of Scientific Adventure	66
Eukaryotic Ribosome Assembly	64
High-Resolution Single-Molecule Magnetic Tweezers	59

Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation	59
mRNA Regulation by RNA Modifications	57
Topoisomerase Regulation of Cancer Gene Expression	56
DNA–Protein Crosslinks and Their Resolution	54
Validating Small Molecule Chemical Probes for Biological Discovery	52
Essential Biology of Lipid Droplets	51
Membrane Protein Complexity Revealed Through Native Mass Spectrometry	49
Structural Biochemistry of Muscle Contraction	47
Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis	47
The Nicotinic Acetylcholine Receptor and Its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level	47
The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes	45
Introduction to the Theme on Membrane Channels	44
	44
Molecular Epigenetics: Chemical Biology Tools Come of Age	42
Natural and Engineered Guide RNA–Directed Transposition with CRISPR-Associated Tn7-Like Transposons	42
Influence of Nonspecific Interactions on Protein Associations: Implications for Biochemistry In Vivo	42
Ribonucleotide Incorporation by Eukaryotic B-Family Replicases and Its Implications for Genome Stability	40
Inositol Pyrophosphates as Versatile Metabolic Messengers	40
Encapsulins	39
Lipid Quality Control and Ferroptosis: From Concept to Mechanism	39
Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway	39
The Story of RNA Unfolded: The Molecular Function of DEAD- and DExH-Box ATPases and Their Complex Relationship with Membraneless Organelles	37
The Bis(monoacylglycero)-phosphate Hypothesis: From Lysosomal Function to Therapeutic Avenues	37
Soluble Human Lectins at the Host–Microbe Interface	36
Rubisco Function, Evolution, and Engineering	35
Looping the Genome with SMC Complexes	35
Molecules from the Microbiome	34
	34
Quality Control of Procollagen in Cells	31
Sensory TRP Channels in Three Dimensions	30
Macrocyclization and Backbone Modification in RiPP Biosynthesis	30
Designing Biological Circuits: Synthetic Biology Within the Operon Model and Beyond	30
Structure and Mechanism of the Lipid Flippase MurJ	28
MAPK-Activated Protein Kinases: Servant or Partner?	27
An Overview of Microcrystal Electron Diffraction (MicroED)	23
Eukaryotic Microproteins	23
Triumphs and Challenges of Natural Product Discovery in the Postgenomic Era	22
Structural Mechanisms for Replicating DNA in Eukaryotes	22
Polyamines in Parkinson's Disease: Balancing Between Neurotoxicity and Neuroprotection	22