OOIR: Observatory of International Research

Papers

(The median citation count of Essays in Biochemistry is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
CRISPR screening in cancer stem cells	134
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing	131
Ligands and DNA in the allosteric control of retinoid receptors function	130
How viral proteins bind short linear motifs and intrinsically disordered domains	112
Butyrate-producing colonic clostridia: picky glycan utilization specialists	109
Phase separation of the microtubule-associated protein tau	106
Salicylic acid and jasmonic acid crosstalk in plant immunity	100
Astrocytes in memory formation and maintenance	76
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling	69
Apoplastic and vascular defences	57
The role of methionine synthases in fungal metabolism and virulence	57
Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?	54
Mineralocorticoid receptor actions in cardiovascular development and disease	52
The dual role of the ubiquitin–proteasome system in photomorphogenesis	51
Perspective on pros and cons of microlearning in health education	47
Malate dehydrogenase: a story of diverse evolutionary radiation	46
Plant peroxisome proteostasis—establishing, renovating, and dismantling the peroxisomal proteome	46
A special issue of Essays in Biochemistry on evolutionary developmental biology	44
The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges	42
Branched-chain amino acid biosynthesis in fungi	42
O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases	41
Mass spectrometric insights into protein aggregation	41
Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease	40
Systemic acquired resistance-associated transport and metabolic regulation of salicylic acid and glycerol-3-phosphate	40
Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling	37

Functional amyloid in a lipid-like environment: a merry dance of many steps	36
Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness	36
Nitrification in acidic and alkaline environments	36
Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine	35
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling	35
Hemicellulolytic enzymes in lignocellulose processing	35
Lipids and the cancer stemness regulatory system in acute myeloid leukemia	34
The molecular basis of cereal grain proteostasis	33
RNA-binding protein dysfunction in neurodegeneration	32
Phase separation and other forms of α-Synuclein self-assemblies	32
Insight into the structure and molecular mode of action of plant paired NLR immune receptors	30
Regulation of R-loops by nucleic acid and protein modifications	30
Vesicular dysfunction and pathways to neurodegeneration	29
Long non-coding RNA and ribosomal protein genes in a yeast ageing model: an investigation for undergraduate research-based learning	28
The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes	28
Plant proteostasis: a proven and promising target for crop improvement	27
Estrogen receptors and the aging brain	27
Nuclear receptor Nur77: its role in chronic inflammatory diseases	26
Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic	25
Membrane lipid raft homeostasis is directly linked to neurodegeneration	25
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?	24
UFM1 at the endoplasmic reticulum: linking ER stress, ribosome quality control, and ER-phagy	23
Harnessing neutrophil plasticity for HCC immunotherapy	23
Evolution of resistance (R) gene specificity	22
Astrocyte heterogeneity and interactions with local neural circuits	22
Sulfate: a neglected (but potentially highly relevant) anion	22
Crossroads between copper ions and amyloid formation in Parkinson’s disease	21
Acetylation, ADP-ribosylation and methylation of malate dehydrogenase	21
The new age of the phage	21
Evo-devo perspectives on cancer	21
Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator	20
Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules	20
WNT signaling and cancer stemness	20
Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function	20
How phosphorylation impacts intrinsically disordered proteins and their function	20
Immunologically relevant effects of radiation therapy on the tumor microenvironment	19
The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagy	19
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents	19
Using epigenetic clocks in environmental epigenetics: recommendations for estimating biological aging in perinatal and pediatric samples	19
Molecular divergence with major morphological consequences: development and evolution of organ size and shape	19
Quantification of persulfidation on specific proteins: are we nearly there yet?	19
Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny	19
The interplay between lytic polysaccharide monooxygenases and glycoside hydrolases	18
Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy	18
Specificity and diversity of Klebsiella pneumoniae phage-encoded capsule depolymerases	18
Molecular plant immunity against biotrophic, hemibiotrophic, and necrotrophic fungi	17
Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling	17
Chemical approaches to the sulfation of small molecules: current progress and future directions	17
Cytosolic sulfotransferases in endocrine disruption	16
Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance	16

Seeing the complete picture: proteins in top-down mass spectrometry	16
Indirect recognition of pathogen effectors by NLRs	16
A proteostasis network safeguards the chloroplast proteome	16
Evolution and functional diversification of yeast sugar transporters	16
Targeted proteolytic products of τ and α-synuclein in neurodegeneration	16
Astrocytes in the pathophysiology of neuroinfection	16
Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy	16
Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation	15
Kinetic modelling of glycolytic oscillations	15
Mass spectrometry of intact membrane proteins: shifting towards a more native-like context	15
What’s new in protein kinase/phosphatase signalling in the control of plant immunity?	15
Gut bacterial alginate degrading enzymes	15
Unconventional R proteins in the botanical tribe Triticeae	15
Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches	14
Is the TCA cycle malate dehydrogenase-citrate synthase metabolon an illusion?	14
Activation and turnover of the plant immune signaling kinase BIK1: a fine balance	14
Understanding SUMO-mediated adaptive responses in plants to improve crop productivity	14
Phage-specific antibodies: are they a hurdle for the success of phage therapy?	14
Cryo-EM structures of τ filaments from human brain	14
Targeting protein kinases in cancer stem cells	14
Small-molecule degron mimetics for targeted protein degradation	13
Effect of multimodularity and spatial organization of glycoside hydrolases on catalysis	13
Diverse mycotoxin threats to safe food and feed cereals	13
NUAK: never underestimate a kinase	13
Developments in rapid hydrogen–deuterium exchange methods	13
Physiology of malate dehydrogenase and how dysregulation leads to disease	12
AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure	12
Oxysterol sulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications?	12
Surface-sampling mass spectrometry to study proteins and protein complexes	12
Ubiquitin ligases at the nexus of plant responses to biotic and abiotic stresses	12
The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer	12
Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function	11
Lytic polysaccharide monooxygenases: enzymes for controlled and site-specific Fenton-like chemistry	11
Engagement with video content in the blended classroom	11
Structure and function of microbial α-l-fucosidases: a mini review	11
Tau aggregation and its relation to selected forms of neuronal cell death	11
Case Study: CRISPR 101 – a novel online learning course harnessing innovative ways to teach a complex biomolecular technology	11
Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses	11
Computational methods for processing and interpreting mass spectrometry-based metabolomics	11
Different states and the associated fates of biomolecular condensates	11
Modelling the evolution of novelty: a review	11
Roles of steroid receptors in the lung and COVID-19	11
Unravelling 3D growth in the moss Physcomitrium patens	11
Volatile uptake, transport, perception, and signaling shape a plant’s nose	10
Colon cancer checks in when bile acids check out: the bile acid–nuclear receptor axis in colon cancer	10
The impact of assessment and feedback practice on the student learning experiences in higher education	10
Astrocytes as metabolic suppliers to support neuronal activity and brain functions	10
Epigenetic impact of endocrine-disrupting chemicals on atherosclerosis	10
Ubiquitination of the ubiquitin-binding machinery: how early ESCRT components are controlled	10
Immune-regulating extracellular vesicles: a new frontier in autoimmune disease therapy	10
A comparative guide to expression systems for phage lysin production	10
Translational research priorities for bacteriophage therapeutics	10
Evolution of SLiM-mediated hijack functions in intrinsically disordered viral proteins	10
Astrocyte adaptation in Alzheimer’s disease: a focus on astrocytic P2X7R	10
Sulfation pathways in times of change	10
Progesterone receptors in normal breast development and breast cancer	10
Mucin utilization by gut microbiota: recent advances on characterization of key enzymes	10
Mannuronate C-5 epimerases and their use in alginate modification	10
Catalytic mechanism and kinetics of malate dehydrogenase	9
Mechanisms of bioleaching: iron and sulfur oxidation by acidophilic microorganisms	9
PINK1 signalling in neurodegenerative disease	9
Cross-linking mass spectrometry for mapping protein complex topologies in situ	9
New molecules in plant defence against pathogens	9
Inflammasome activation in neurodegenerative diseases	9
Interplay between phytohormone signalling pathways in plant defence – other than salicylic acid and jasmonic acid	9
Does AMPK bind glycogen in skeletal muscle or is the relationship correlative?	9
HECT ubiquitin ligases as accessory proteins of the plant proteasome	9
Rab GTPases in Parkinson's disease: a primer	9