OOIR: Observatory of International Research

Papers

(The median citation count of Essays in Biochemistry is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Ligands and DNA in the allosteric control of retinoid receptors function	466
Butyrate-producing colonic clostridia: picky glycan utilization specialists	128
How viral proteins bind short linear motifs and intrinsically disordered domains	127
CRISPR screening in cancer stem cells	120
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing	100
Salicylic acid and jasmonic acid crosstalk in plant immunity	96
Phase separation of the microtubule-associated protein tau	95
Malate dehydrogenase: a story of diverse evolutionary radiation	86
Mineralocorticoid receptor actions in cardiovascular development and disease	74
Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?	67
The role of methionine synthases in fungal metabolism and virulence	63
Plant long non-coding RNAs in the regulation of transcription	54
Astrocytes in memory formation and maintenance	54
Apoplastic and vascular defences	52
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling	47
Comparative genomics in the search for conserved long noncoding RNAs	45
Perspective on pros and cons of microlearning in health education	44
A special issue of Essays in Biochemistry on evolutionary developmental biology	43
Plant peroxisome proteostasis—establishing, renovating, and dismantling the peroxisomal proteome	40
The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges	40
O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases	40
Mass spectrometric insights into protein aggregation	38
Branched-chain amino acid biosynthesis in fungi	37
Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease	37
Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine	36

Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling	35
Functional amyloid in a lipid-like environment: a merry dance of many steps	34
Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling	33
SINEUPs: a novel toolbox for RNA therapeutics	33
Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness	33
Nitrification in acidic and alkaline environments	32
Hemicellulolytic enzymes in lignocellulose processing	32
Systemic acquired resistance-associated transport and metabolic regulation of salicylic acid and glycerol-3-phosphate	31
Phase separation and other forms of α-Synuclein self-assemblies	30
Lipids and the cancer stemness regulatory system in acute myeloid leukemia	30
Insight into the structure and molecular mode of action of plant paired NLR immune receptors	29
Vesicular dysfunction and pathways to neurodegeneration	28
The molecular basis of cereal grain proteostasis	28
RNA-binding protein dysfunction in neurodegeneration	28
Long non-coding RNA and ribosomal protein genes in a yeast ageing model: an investigation for undergraduate research-based learning	27
Plant proteostasis: a proven and promising target for crop improvement	26
Estrogen receptors and the aging brain	25
The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes	25
Membrane lipid raft homeostasis is directly linked to neurodegeneration	25
Astrocyte heterogeneity and interactions with local neural circuits	24
Nuclear receptor Nur77: its role in chronic inflammatory diseases	24
Evolution of resistance (R) gene specificity	23
Long non-coding RNAs and splicing	22
Functional annotation of lncRNA in high-throughput screening	22
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?	22
Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic	22
Harnessing neutrophil plasticity for HCC immunotherapy	21
Long non-coding RNAs associated with infection and vaccine-induced immunity	21
Evo-devo perspectives on cancer	20
Sulfate: a neglected (but potentially highly relevant) anion	20
The non-coding genome in genetic brain disorders: new targets for therapy?	19
Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator	19
WNT signaling and cancer stemness	19
The new age of the phage	19
Acetylation, ADP-ribosylation and methylation of malate dehydrogenase	19
Quantification of persulfidation on specific proteins: are we nearly there yet?	19
Crossroads between copper ions and amyloid formation in Parkinson’s disease	19
Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules	19
How phosphorylation impacts intrinsically disordered proteins and their function	19
Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function	19
Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny	18
Immunologically relevant effects of radiation therapy on the tumor microenvironment	18
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents	18
Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy	18
Molecular divergence with major morphological consequences: development and evolution of organ size and shape	18
The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagy	17
Specificity and diversity of Klebsiella pneumoniae phage-encoded capsule depolymerases	17
The interplay between lytic polysaccharide monooxygenases and glycoside hydrolases	17
Molecular plant immunity against biotrophic, hemibiotrophic, and necrotrophic fungi	17
Using epigenetic clocks in environmental epigenetics: recommendations for estimating biological aging in perinatal and pediatric samples	17

Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy	17
Cytosolic sulfotransferases in endocrine disruption	16
Chemical approaches to the sulfation of small molecules: current progress and future directions	16
Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance	16
Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling	16
A proteostasis network safeguards the chloroplast proteome	16
Evolution and functional diversification of yeast sugar transporters	16
Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation	15
Indirect recognition of pathogen effectors by NLRs	15
Astrocytes in the pathophysiology of neuroinfection	15
Targeted proteolytic products of τ and α-synuclein in neurodegeneration	15
Seeing the complete picture: proteins in top-down mass spectrometry	15
Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches	15
Mass spectrometry of intact membrane proteins: shifting towards a more native-like context	15
Is the TCA cycle malate dehydrogenase-citrate synthase metabolon an illusion?	14
Understanding SUMO-mediated adaptive responses in plants to improve crop productivity	14
Unconventional R proteins in the botanical tribe Triticeae	14
Gut bacterial alginate degrading enzymes	14
Kinetic modelling of glycolytic oscillations	14
Cryo-EM structures of τ filaments from human brain	14
What’s new in protein kinase/phosphatase signalling in the control of plant immunity?	14
Effect of multimodularity and spatial organization of glycoside hydrolases on catalysis	13
The evolutionary acquisition and mode of functions of promoter-associated non-coding RNAs (pancRNAs) for mammalian development	13
Developments in rapid hydrogen–deuterium exchange methods	13
Targeting protein kinases in cancer stem cells	13
Phage-specific antibodies: are they a hurdle for the success of phage therapy?	13
Activation and turnover of the plant immune signaling kinase BIK1: a fine balance	13
The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer	12
Diverse mycotoxin threats to safe food and feed cereals	12
Surface-sampling mass spectrometry to study proteins and protein complexes	12
NUAK: never underestimate a kinase	12
Non-coding RNA in cancer	12
Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function	11
Case Study: CRISPR 101 – a novel online learning course harnessing innovative ways to teach a complex biomolecular technology	11
Tau aggregation and its relation to selected forms of neuronal cell death	11
Unravelling 3D growth in the moss Physcomitrium patens	11
Ubiquitin ligases at the nexus of plant responses to biotic and abiotic stresses	11
Modelling the evolution of novelty: a review	11
Different states and the associated fates of biomolecular condensates	11
Physiology of malate dehydrogenase and how dysregulation leads to disease	11
AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure	11
Oxysterol sulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications?	11
Engagement with video content in the blended classroom	11
Lytic polysaccharide monooxygenases: enzymes for controlled and site-specific Fenton-like chemistry	11
Computational methods for processing and interpreting mass spectrometry-based metabolomics	10
Mucin utilization by gut microbiota: recent advances on characterization of key enzymes	10
Immune-regulating extracellular vesicles: a new frontier in autoimmune disease therapy	10
Roles of steroid receptors in the lung and COVID-19	10
Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses	10
Sulfation pathways in times of change	10
Translational research priorities for bacteriophage therapeutics	10
Colon cancer checks in when bile acids check out: the bile acid–nuclear receptor axis in colon cancer	10
Structure and function of microbial α-l-fucosidases: a mini review	10
The impact of assessment and feedback practice on the student learning experiences in higher education	10
Volatile uptake, transport, perception, and signaling shape a plant’s nose	9
Astrocyte adaptation in Alzheimer’s disease: a focus on astrocytic P2X7R	9
Catalytic mechanism and kinetics of malate dehydrogenase	9
New molecules in plant defence against pathogens	9
Progesterone receptors in normal breast development and breast cancer	9
Evolution of SLiM-mediated hijack functions in intrinsically disordered viral proteins	9
Interplay between phytohormone signalling pathways in plant defence – other than salicylic acid and jasmonic acid	9
A comparative guide to expression systems for phage lysin production	9
Astrocytes as metabolic suppliers to support neuronal activity and brain functions	9
Cross-linking mass spectrometry for mapping protein complex topologies in situ	9
Ubiquitination of the ubiquitin-binding machinery: how early ESCRT components are controlled	9
Rab GTPases in Parkinson's disease: a primer	8
Mechanisms of bioleaching: iron and sulfur oxidation by acidophilic microorganisms	8
Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers: current status and perspectives	8
Carbohydrate esterases involved in deacetylation of food components by the human gut microbiota	8
Mannuronate C-5 epimerases and their use in alginate modification	8
PINK1 signalling in neurodegenerative disease	8
Understanding and computational design of genetic circuits of metabolic networks	8
Eco-Evo-Devo of petal pigmentation patterning	8
A special issue of Essays in Biochemistry on current educational developments in molecular bioscience	8
HECT ubiquitin ligases as accessory proteins of the plant proteasome	8
Does AMPK bind glycogen in skeletal muscle or is the relationship correlative?	8
Inflammasome activation in neurodegenerative diseases	8
Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease	8
Uptake of formative feedback: perspective from a transnational education cohort	8
Epigenetic impact of endocrine-disrupting chemicals on atherosclerosis	8