OOIR: Observatory of International Research

Papers

(The TQCC of Essays in Biochemistry is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Ligands and DNA in the allosteric control of retinoid receptors function	466
Butyrate-producing colonic clostridia: picky glycan utilization specialists	128
How viral proteins bind short linear motifs and intrinsically disordered domains	127
CRISPR screening in cancer stem cells	120
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing	100
Salicylic acid and jasmonic acid crosstalk in plant immunity	96
Phase separation of the microtubule-associated protein tau	95
Malate dehydrogenase: a story of diverse evolutionary radiation	86
Mineralocorticoid receptor actions in cardiovascular development and disease	74
Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?	67
The role of methionine synthases in fungal metabolism and virulence	63
Astrocytes in memory formation and maintenance	54
Plant long non-coding RNAs in the regulation of transcription	54
Apoplastic and vascular defences	52
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling	47
Comparative genomics in the search for conserved long noncoding RNAs	45
Perspective on pros and cons of microlearning in health education	44
A special issue of Essays in Biochemistry on evolutionary developmental biology	43
O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases	40
Plant peroxisome proteostasis—establishing, renovating, and dismantling the peroxisomal proteome	40
The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges	40
Mass spectrometric insights into protein aggregation	38
Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease	37
Branched-chain amino acid biosynthesis in fungi	37
Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine	36

Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling	35
Functional amyloid in a lipid-like environment: a merry dance of many steps	34
Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling	33
SINEUPs: a novel toolbox for RNA therapeutics	33
Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness	33
Nitrification in acidic and alkaline environments	32
Hemicellulolytic enzymes in lignocellulose processing	32
Systemic acquired resistance-associated transport and metabolic regulation of salicylic acid and glycerol-3-phosphate	31
Phase separation and other forms of α-Synuclein self-assemblies	30
Lipids and the cancer stemness regulatory system in acute myeloid leukemia	30
Insight into the structure and molecular mode of action of plant paired NLR immune receptors	29
RNA-binding protein dysfunction in neurodegeneration	28
Vesicular dysfunction and pathways to neurodegeneration	28
The molecular basis of cereal grain proteostasis	28
Long non-coding RNA and ribosomal protein genes in a yeast ageing model: an investigation for undergraduate research-based learning	27
Plant proteostasis: a proven and promising target for crop improvement	26
Membrane lipid raft homeostasis is directly linked to neurodegeneration	25
Estrogen receptors and the aging brain	25
The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes	25
Astrocyte heterogeneity and interactions with local neural circuits	24
Nuclear receptor Nur77: its role in chronic inflammatory diseases	24
Evolution of resistance (R) gene specificity	23
Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic	22
Long non-coding RNAs and splicing	22
Functional annotation of lncRNA in high-throughput screening	22
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?	22
Long non-coding RNAs associated with infection and vaccine-induced immunity	21
Harnessing neutrophil plasticity for HCC immunotherapy	21
Evo-devo perspectives on cancer	20
Sulfate: a neglected (but potentially highly relevant) anion	20
How phosphorylation impacts intrinsically disordered proteins and their function	19
Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function	19
The non-coding genome in genetic brain disorders: new targets for therapy?	19
Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator	19
WNT signaling and cancer stemness	19
The new age of the phage	19
Acetylation, ADP-ribosylation and methylation of malate dehydrogenase	19
Quantification of persulfidation on specific proteins: are we nearly there yet?	19
Crossroads between copper ions and amyloid formation in Parkinson’s disease	19
Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules	19
Molecular divergence with major morphological consequences: development and evolution of organ size and shape	18
Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny	18
Immunologically relevant effects of radiation therapy on the tumor microenvironment	18
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents	18
Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy	18
Using epigenetic clocks in environmental epigenetics: recommendations for estimating biological aging in perinatal and pediatric samples	17
Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy	17
The COP9 signalosome variants CSNCSN7A and CSNCSN7B form complexes with specific CRLs which are targets of autophagy	17
Specificity and diversity of Klebsiella pneumoniae phage-encoded capsule depolymerases	17
The interplay between lytic polysaccharide monooxygenases and glycoside hydrolases	17

Molecular plant immunity against biotrophic, hemibiotrophic, and necrotrophic fungi