OOIR: Observatory of International Research

Papers

(The H4-Index of Drug Metabolism and disPosition is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone	97
Human enteroid monolayers: A novel, functionally stable model for investigating oral drug disposition	85
Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies	70
Recommendations on the Use of Multiple Labels in Human Mass Balance Studies	68
Physiologically Based Pharmacokinetic Modeling To Predict Drug-Biologic Interactions with Cytokine Modulators: Are These Relevant and Is Interleukin-6 Enough?	66
Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice	56
Pharmacokinetic Effects of Different Models of Nonalcoholic Fatty Liver Disease in Transgenic Humanized OATP1B Mice	54
HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation	47
Epigenetic Activation of Cytochrome P450 1A2 Sensitizes Hepatocellular Carcinoma Cells to Sorafenib	46
Chronic Exposure to E-Cigarettes Elevates CYP2A5 Activity, Protein Expression, and Cotinine-Induced Production of Reactive Oxygen Species in Mice	46
Novel O-methylpyrimidine prodrugs of phenolic compounds bioactivated by aldehyde oxidase: Enhancing metabolic stability against first-pass conjugative metabolism in the intestine	41
Oleuropein-Induced Acceleration of Cytochrome P450–Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor α	39
Editorial Board	35
Integrative Analysis of Histone Acetylation Regulated CYP4F12 in Esophageal Cancer Development	35
Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N-Acetylgalactosamine–Conjugated RNA Interference Therapeutic	35
Editorial Board	33
The Impact of Age and Genetics on Naltrexone Biotransformation	33
Contents	32
Editorial Board	31
A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation	31
Editorial Board	31
Editorial Board	30
Table of Contents	30
Is the Protein-Mediated Uptake of Drugs by Organic Anion Transporting Polypeptides a Real Phenomenon or an Artifact?	30
Impact of Inflammation and Infection on the Expression of Amino Acid Transporters in the Placenta: A Minireview	30

Editorial Board	29
Table of Contents	28
Editorial Board	28
Cytochrome b5 Binds Tightly to Several Human Cytochrome P450 Enzymes	28