OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacology Biochemistry and Behavior is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Editorial Board	81
Do greater levels of in-cage waking inactivity in laboratory mice reflect a spontaneous depression-like symptom? A pharmacological investigation	53
Editorial Board	47
Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats	41
Editorial Board	33
Maternal fluoxetine impairs synaptic transmission and plasticity in the medial prefrontal cortex and alters the structure and function of dorsal raphe nucleus neurons in offspring mice	33
Prenatal serotonin depletion persistently disrupts social behavior and modulates ΔFosB and SERT expression in mice	32
Chronic inflammatory pain reduces fentanyl intake during early acquisition of fentanyl self-administration, but does not change motivation to take fentanyl in male and female rats	31
Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice	29
Attenuation of nicotine-induced rewarding and antidepressant-like effects in male and female mice lacking regulator of G-protein signaling 2	29
Agomelatine with cognitive behavioral therapy reduces insomnia severity index and subjective units of distress scores than initial-dose clonazepam in moderate to severe insomnia patients: A quasi-expe	27
The endowment effect and temporal discounting of drug and non-drug commodities	25
Anxiolytic-like effects of milk proteins	25
Pharmacological and genetic manipulation of glyoxalase-1 (GLO1) does not alter locomotor responses or conditioned place preference induced by cocaine or oxycodone.	25
Increased anxiolytic effect in aged female rats and increased motoric behavior in aged male rats to acute alcohol administration: Comparison to younger animals	25
Protein kinases in natural versus drug reward	24
Fluoxetine attenuates the anxiolytic effects of the probiotic VSL#3 in a stress-vulnerable genetic line of aves in the chick social-separation stress test, a dual screening assay	24
Prenatal maternal stress induces increased avoidance behavior in adolescent mice offspring	23
iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression	22
Pramipexole decreases allodynia and hyperalgesia via NF-κB in astrocytes in rats with Parkinson's disease	22
Simultaneous cocaine and ethanol self-administration promotes a sex-dimorphic pattern in drug-seeking behaviour and alters plasma amino acid profile related to glutamate homeostasis in young adult rat	22
Editorial Board	21
Sleep, psychiatric and socioeconomic factors associated with substance use in a large population sample: A cross-sectional study	21
Editorial Board	21
Editorial Board	21

Challenge exposure to whole cigarette smoke condensate upregulates locomotor sensitization by stimulating α4β2 nicotinic acetylcholine receptors in the nucleus accumbens of rats	19
The novel synthesized naltrexone-related MOR antagonist AT-99 counteracts dopamine releasing and behavioral depressant morphine-induced effects	19
Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats	19
Chronic cannabis use alters dACC-striatal glutamatergic balance	18
The dosage-dependent effects of cevimeline in preventing clozapine-induced dyslipidaemia in female rats	18
Single cannabidiol administration affects anxiety-, obsessive compulsive-, object memory-, and attention-like behaviors in mice in a sex and concentration dependent manner	18
Ramelteon protects against social defeat stress-associated abnormal behaviors	17
Reconsidering OCD pharmacotherapy: The case for levomilnacipran as a safer alternative to clomipramine	17
Drug discrimination learning: Interoceptive stimulus control of behavior and its implications for regulated and dysregulated drug intake	17
Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice	17
The α2C-adrenoceptor antagonist JP-1302 controls behavioral parameters, tyrosine hydroxylase activity and receptor expression in a rat model of ketamine-induced schizophrenia-like deficits	16
Region-specific alterations in the expression and phosphorylation of NMDA receptor subunits in the rat prefrontal cortex and dorsal striatum accompanying behavioral sensitization induced by cocaine an	16
QCTA-1, a quinoline derivative, ameliorates pentylenetetrazole-induced kindling and memory comorbidity in mice: Involvement of antioxidant system of brain.	15
Divergent emotional and autonomic responses to Cyberball in patients with opioid use disorder on opioid agonist treatment	15
The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice	15
Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice	15
Acute exercise performed during the late consolidation phase improves memory persistence by hippocampal protein synthesis and catecholamine modulation	14
Sucrose intake and preference by Wistar Han rats are not influenced by sex or food/water deprivation	13
Population-dependent impacts of para-chlorophenylalanine, a tryptophan hydroxylase inhibitor, on homebase formation and thigmotaxis in adult zebrafish	13
Depression-like behaviors in mouse model of Sjögren's syndrome: A role of gut–microbiota–brain axis	13
Editorial Board	13
Psychopharmacology across the Lifespan	12
Male, but not female, Sprague Dawley rats display enhanced fear learning following acute ethanol withdrawal (hangover)	12
Cannabidiol treatment prevents drug reinstatement and the molecular alterations evoked by amphetamine on receptors and enzymes from dopaminergic and endocannabinoid systems in rats	12
Nebulized and intraperitoneal ketamine have equivalent antidepressant-like effect in the forced swim and tail suspension tests in mice	12
Morphine restores and naloxone-precipitated withdrawal depresses wheel running in rats with hindpaw inflammation	12
Sex differences on the response to antidepressants and psychobiotics following early life stress in rats	12
Behavioral and pharmacological interventions for the prevention and treatment of psychiatric disorders with children exposed to maltreatment	12
Editorial Board	12
Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age	12
Treating cocaine and opioid use disorder with transcranial magnetic stimulation: A path forward	12
Esketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of mGluR5 in depressive-like rats	12
The inhibitory effect of nicotine on Lumbriculus variegatus stereotypical movements and locomotor activity	11
Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats	11
Editorial Board	11
Editorial for the 50th anniversary of Pharmacology Biochemistry and Behavior	11
Emerging medications and pharmacological treatment approaches for substance use disorders	11
Ketamine modulates the exploratory dynamics and homebase-related behaviors of adult zebrafish	11
Neuroprotective effect of histamine H3 receptor blockade on methamphetamine-induced cognitive impairment in mice	11
Enantiomeric contributions to methamphetamine's bidirectional effects on basal and fentanyl-depressed respiration in mice	11
Interactions between lorcaserin and opioids: Ventilation and food-versus-drug choice	11
Preliminary investigation of the administration of biperiden to reduce relapses in individuals with cocaine/crack user disorder: A randomized controlled clinical trial	11
Microbiome depletion by broad-spectrum antibiotics does not influence demyelination and remyelination in cuprizone-treated mice	10
Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability	10
Anxiolytic-like effects of an mGluR 5 antagonist and a mGluR 2/3 agonist, and antidepressant-like effects of an mGluR 7 agonist in the chick social separation stress test, a dual-drug screening model	10
Biochemical challenges for testing novel anti-panic drugs in humans	10
Contextual and psychosocial factors influencing drug reward in humans: The importance of non-drug reinforcement	10
Structurally diverse fentanyl analogs yield differential locomotor activities in mice	10
Chronic administration of caffeine, modafinil, AVL-3288 and CX516 induces time-dependent complex effects on cognition and mood in an animal model of sleep deprivation	10
Role of social context in addiction etiology and recovery	10

Adult and adolescent antipsychotic exposure increases delay discounting and diminishes behavioral flexibility in male C57BL/6 mice	10
Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking	10
Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach	10
A spotlight on HCV and SARS-CoV-2 co-infection and brain function	10
Modulation of circuit oscillations in the rat anterior cingulate cortex (ACC) in vitro by mGlu2 metabotropic glutamate receptors and alleviation of the effects of phencyclidine-induced NMDA-receptor h	9
Chronic levetiracetam (Keppra®) treatment increases the reinforcing strength of cocaine in rhesus monkeys	9
Editorial Board	9
Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model	9
Acute MK-801 increases measures of both sign-tracking and goal-tracking in male Sprague-Dawley rats	9
The romantic age of pharmacological science	9
Simultaneous use of venlafaxine and calcium channel blockers on tolerance to morphine: The role of mitochondrial damage and oxidative stress in the brain	8
Gender differences in the relationship between nicotine exposure and symptoms of depression	8
Activation of NOS-cGMP pathways promotes stress-induced sensitization of behavioral responses in zebrafish	8
Modulation of mGlu5 improves sensorimotor gating deficits in rats neonatally treated with quinpirole through changes in dopamine D2 signaling	8
Naltrexone-bupropion combinations do not affect cocaine self-administration in humans	8
Hippocampus-sensitive and striatum-sensitive learning one month after morphine or cocaine exposure in male rats	8
5-HT2C agonists and antagonists block different components of behavioral responses to potential, distal, and proximal threat in zebrafish	8
Object recognition and Morris water maze to detect cognitive impairment from mild hippocampal damage in rats: A reflection based on the literature and experience	8
Chronic exposure of female mice to selective serotonin reuptake inhibitors during lactation induces vocal behavior deficits in pre-weaned offspring	8
Distinctively lower DISC1 mRNA levels in patients with schizophrenia, especially in those with higher positive, negative, and depressive symptoms	8
Impulsivity and aggression in alcohol withdrawal syndrome is modulated by the interaction of ZNF804A and mTOR polymorphism	8
Sex differences in serotonergic control of rat social behaviour	8
Blocking the ErbB pathway during adolescence affects the induction of anxiety-like behavior in young adult maternal immune activation offspring	8
Glucocorticoid- β-adrenoceptors interactions in the infralimbic cortex in acquisition and consolidation of auditory fear memory extinction in rats	8
Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review	7
Caffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression	7
Advances in translating mGlu2 and mGlu3 receptor selective allosteric modulators as breakthrough treatments for affective disorders and alcohol use disorder	7
Sex-dependent and long-lasting effects of adolescent sleep deprivation on social behaviors in adult mice	7
Unlocking the age-old secrets of reward and substance use	7
Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury	7
Differential disruption of response alternation by precipitated Δ9-THC withdrawal and subsequent Δ9-THC abstinence in mice	7
ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice	7
Substance use disorder is the outcome of deviant socialization: A prospective investigation spanning childhood to adulthood	7
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression	7
Psychologically traumatic stress inducing redox – inflammation interplay; which comes first?	7
Transmission of the adverse consequences of childhood maltreatment across generations: Focus on gestational biology	7
Cocaine diminishes consolidation of cued fear memory in female rats through interactions with ventral hippocampal D2 receptors	7
Editorial Board	7
Early adolescent second-generation antipsychotic exposure produces long-term, post-treatment increases in body weight and metabolism-associated gene expression	7
Sex, but not juvenile stress, affects reversal learning and DRL performance following cocaine administration	7
Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex	7
Deciphering the gut microbiota's (Coprococcus and Subdoligranulum) impact on depression: Network pharmacology and molecular dynamics simulation	7
Environmental enrichment enhances the antidepressant effect of ketamine and ameliorates spatial memory deficits in adult rats	7
Alpha-pyrrolidinopentiothiophenone (α-PVT) activates the TLR–NF-κB–MAPK signaling pathway and proinflammatory cytokine production and induces behavioral sensitization in mice	7
The antidepressant agomelatine attenuates morphine-induced reinstatement but not self-administration or precipitated withdrawal	6
Context evoked morphine conditioned effects can be equivalent to morphine induced drug effects in terms of behavioral response and ERK activation in reward associated subcortical brain structures	6
Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model	6
Unconventional anxiety pharmacology in zebrafish: Drugs beyond traditional anxiogenic and anxiolytic spectra	6
The piperazine analogue para-fluorophenylpiperazine alters timing of the physiological effects of the synthetic cannabinoid receptor agonist AMB-FUBINACA, without changing its discriminative stimulus,	6
Differential patterns of opioid and dopamine D1 receptor antagonism on nutritive and non-nutritive sweetener intakes in C57BL/6:129 hybrid mice relative to inbred C57BL/6 and 129 mice	6
Time course of plasticity-related alterations following the first exposure to amphetamine in juvenile rats	6
Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress	6
Adolescent alcohol exposure modifies adult anxiety-like behavior and amygdala sensitivity to alcohol in rats: Increased c-Fos activity and sex-dependent microRNA-182 expression	6
Ligands of the trace amine-associated receptors (TAARs): A new class of anxiolytics	6
Sex differences in long-term behavioral alterations, especially anxiety, following prenatal fluoxetine exposure in C57BL/6 mice	6
Pentylenetetrazole kindling induces dynamic changes in GAD65 expression in hippocampal somatostatin interneurons	6
The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 does not affect food intake in rats	6
Editorial Board	6
The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders	6
The blockade of orexin receptors within the dentate gyrus of the hippocampus attenuated methamphetamine-induced reward learning during conditioning place preference	6
SGK1.1 isoform is involved in nociceptive modulation, offering a protective effect against noxious cold stimulus in a sexually dimorphic manner	6
Age-related changes in CB1 receptor expression and function and the behavioral effects of cannabinoid receptor ligands	6
Ndufs4 KO mice: A model to study comorbid mood disorders associated with mitochondrial dysfunction	6
Swimming exercise reduces the vulnerability to stress and contributes to the AKT/GSK3β/CRMP2 pathway and microtubule dynamics mediated protective effects on neuroplasticity in male C57BL/6 mice	6
Role of mGlu receptors in psychiatric disorders – Recent advances	6