OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacology Biochemistry and Behavior is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Editorial Board	77
Do greater levels of in-cage waking inactivity in laboratory mice reflect a spontaneous depression-like symptom? A pharmacological investigation	50
Editorial Board	44
Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats	39
Editorial Board	30
Maternal fluoxetine impairs synaptic transmission and plasticity in the medial prefrontal cortex and alters the structure and function of dorsal raphe nucleus neurons in offspring mice	29
Chronic inflammatory pain reduces fentanyl intake during early acquisition of fentanyl self-administration, but does not change motivation to take fentanyl in male and female rats	29
Prenatal serotonin depletion persistently disrupts social behavior and modulates ΔFosB and SERT expression in mice	28
Attenuation of nicotine-induced rewarding and antidepressant-like effects in male and female mice lacking regulator of G-protein signaling 2	28
Pramipexole decreases allodynia and hyperalgesia via NF-κB in astrocytes in rats with Parkinson's disease	26
iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression	25
Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice	25
Protective role of endocannabinoid signaling in an animal model of haloperidol-induced tardive dyskinesia	23
The endowment effect and temporal discounting of drug and non-drug commodities	23
Agomelatine with cognitive behavioral therapy reduces insomnia severity index and subjective units of distress scores than initial-dose clonazepam in moderate to severe insomnia patients: A quasi-expe	23
Increased anxiolytic effect in aged female rats and increased motoric behavior in aged male rats to acute alcohol administration: Comparison to younger animals	23
Anxiolytic-like effects of milk proteins	22
Protein kinases in natural versus drug reward	22
Fluoxetine attenuates the anxiolytic effects of the probiotic VSL#3 in a stress-vulnerable genetic line of aves in the chick social-separation stress test, a dual screening assay	22
Chronic cannabis use alters dACC-striatal glutamatergic balance	21
Simultaneous cocaine and ethanol self-administration promotes a sex-dimorphic pattern in drug-seeking behaviour and alters plasma amino acid profile related to glutamate homeostasis in young adult rat	21
Donepezil prevents morphine tolerance by regulating N-methyl-d-aspartate receptor, protein kinase C and CaM-dependent kinase II expression in rats	21
Editorial Board	20
Editorial Board	19
Editorial Board	19

Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats	18
Challenge exposure to whole cigarette smoke condensate upregulates locomotor sensitization by stimulating α4β2 nicotinic acetylcholine receptors in the nucleus accumbens of rats	18
Sleep, psychiatric and socioeconomic factors associated with substance use in a large population sample: A cross-sectional study	18
Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice	17
Reconsidering OCD pharmacotherapy: The case for levomilnacipran as a safer alternative to clomipramine	17
Ramelteon protects against social defeat stress-associated abnormal behaviors	17
Drug discrimination learning: Interoceptive stimulus control of behavior and its implications for regulated and dysregulated drug intake	17
Divergent emotional and autonomic responses to Cyberball in patients with opioid use disorder on opioid agonist treatment	16
Region-specific alterations in the expression and phosphorylation of NMDA receptor subunits in the rat prefrontal cortex and dorsal striatum accompanying behavioral sensitization induced by cocaine an	16
The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice	16
Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice	16
Single cannabidiol administration affects anxiety-, obsessive compulsive-, object memory-, and attention-like behaviors in mice in a sex and concentration dependent manner	16
QCTA-1, a quinoline derivative, ameliorates pentylenetetrazole-induced kindling and memory comorbidity in mice: Involvement of antioxidant system of brain.	16
The α2C-adrenoceptor antagonist JP-1302 controls behavioral parameters, tyrosine hydroxylase activity and receptor expression in a rat model of ketamine-induced schizophrenia-like deficits	16
Sucrose intake and preference by Wistar Han rats are not influenced by sex or food/water deprivation	15
Acute exercise performed during the late consolidation phase improves memory persistence by hippocampal protein synthesis and catecholamine modulation	15
Nebulized and intraperitoneal ketamine have equivalent antidepressant-like effect in the forced swim and tail suspension tests in mice	15
Depression-like behaviors in mouse model of Sjögren's syndrome: A role of gut–microbiota–brain axis	15
Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age	14
Editorial Board	14
Morphine restores and naloxone-precipitated withdrawal depresses wheel running in rats with hindpaw inflammation	13
Magnitude of open-field thigmotaxis during mecamylamine-precipitated nicotine withdrawal in rats is influenced by mecamylamine dose, duration of nicotine infusion, number of withdrawal episodes, and a	13
Psychopharmacology across the Lifespan	13
Cannabidiol treatment prevents drug reinstatement and the molecular alterations evoked by amphetamine on receptors and enzymes from dopaminergic and endocannabinoid systems in rats	12
Emerging medications and pharmacological treatment approaches for substance use disorders	12
Treating cocaine and opioid use disorder with transcranial magnetic stimulation: A path forward	12
Esketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of mGluR5 in depressive-like rats	12
The inhibitory effect of nicotine on Lumbriculus variegatus stereotypical movements and locomotor activity	12
Male, but not female, Sprague Dawley rats display enhanced fear learning following acute ethanol withdrawal (hangover)	12
Behavioral and pharmacological interventions for the prevention and treatment of psychiatric disorders with children exposed to maltreatment	12
Enantiomeric contributions to methamphetamine's bidirectional effects on basal and fentanyl-depressed respiration in mice	11
Chronic administration of caffeine, modafinil, AVL-3288 and CX516 induces time-dependent complex effects on cognition and mood in an animal model of sleep deprivation	11
Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats	11
Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats	11
Ketamine modulates the exploratory dynamics and homebase-related behaviors of adult zebrafish	11
Adult and adolescent antipsychotic exposure increases delay discounting and diminishes behavioral flexibility in male C57BL/6 mice	11
Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking	11
Sex differences on the response to antidepressants and psychobiotics following early life stress in rats	11
Editorial for the 50th anniversary of Pharmacology Biochemistry and Behavior	11
Microbiome depletion by broad-spectrum antibiotics does not influence demyelination and remyelination in cuprizone-treated mice	11
Interactions between lorcaserin and opioids: Ventilation and food-versus-drug choice	10
Preliminary investigation of the administration of biperiden to reduce relapses in individuals with cocaine/crack user disorder: A randomized controlled clinical trial	10
Role of social context in addiction etiology and recovery	10
Anxiolytic-like effects of an mGluR 5 antagonist and a mGluR 2/3 agonist, and antidepressant-like effects of an mGluR 7 agonist in the chick social separation stress test, a dual-drug screening model	10
Editorial Board	10
Contextual and psychosocial factors influencing drug reward in humans: The importance of non-drug reinforcement	10
Structurally diverse fentanyl analogs yield differential locomotor activities in mice	10
Neuroprotective effect of histamine H3 receptor blockade on methamphetamine-induced cognitive impairment in mice	10
Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach	10
Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability	10

A spotlight on HCV and SARS-CoV-2 co-infection and brain function	10
Modulation of circuit oscillations in the rat anterior cingulate cortex (ACC) in vitro by mGlu2 metabotropic glutamate receptors and alleviation of the effects of phencyclidine-induced NMDA-receptor h	9
Biochemical challenges for testing novel anti-panic drugs in humans	9
5-HT2C agonists and antagonists block different components of behavioral responses to potential, distal, and proximal threat in zebrafish	9
Editorial Board	9
Acute MK-801 increases measures of both sign-tracking and goal-tracking in male Sprague-Dawley rats	9
Activation of NOS-cGMP pathways promotes stress-induced sensitization of behavioral responses in zebrafish	8
Chronic levetiracetam (Keppra®) treatment increases the reinforcing strength of cocaine in rhesus monkeys	8
Simultaneous use of venlafaxine and calcium channel blockers on tolerance to morphine: The role of mitochondrial damage and oxidative stress in the brain	8
Modulation of mGlu5 improves sensorimotor gating deficits in rats neonatally treated with quinpirole through changes in dopamine D2 signaling	8
Object recognition and Morris water maze to detect cognitive impairment from mild hippocampal damage in rats: A reflection based on the literature and experience	8
Chronic exposure of female mice to selective serotonin reuptake inhibitors during lactation induces vocal behavior deficits in pre-weaned offspring	8
Sex differences in serotonergic control of rat social behaviour	8
Blocking the ErbB pathway during adolescence affects the induction of anxiety-like behavior in young adult maternal immune activation offspring	8
Distinctively lower DISC1 mRNA levels in patients with schizophrenia, especially in those with higher positive, negative, and depressive symptoms	8
Gender differences in the relationship between nicotine exposure and symptoms of depression	8
Impulsivity and aggression in alcohol withdrawal syndrome is modulated by the interaction of ZNF804A and mTOR polymorphism	8
Hippocampus-sensitive and striatum-sensitive learning one month after morphine or cocaine exposure in male rats	8
The romantic age of pharmacological science	8
Naltrexone-bupropion combinations do not affect cocaine self-administration in humans	8
Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model	8
Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review	7
Early adolescent second-generation antipsychotic exposure produces long-term, post-treatment increases in body weight and metabolism-associated gene expression	7
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression	7
Caffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression	7
Enhancement of cue-induced reinstatement of alcohol seeking by acute total sleep restriction in male Wistar rats	7
Advances in translating mGlu2 and mGlu3 receptor selective allosteric modulators as breakthrough treatments for affective disorders and alcohol use disorder	7
The blockade of orexin receptors within the dentate gyrus of the hippocampus attenuated methamphetamine-induced reward learning during conditioning place preference	7
Differential disruption of response alternation by precipitated Δ9-THC withdrawal and subsequent Δ9-THC abstinence in mice	7
Time course of plasticity-related alterations following the first exposure to amphetamine in juvenile rats	7
Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury	7
Psychologically traumatic stress inducing redox – inflammation interplay; which comes first?	7
Transmission of the adverse consequences of childhood maltreatment across generations: Focus on gestational biology	7
Glucocorticoid- β-adrenoceptors interactions in the infralimbic cortex in acquisition and consolidation of auditory fear memory extinction in rats	7
Environmental enrichment enhances the antidepressant effect of ketamine and ameliorates spatial memory deficits in adult rats	7
Sex, but not juvenile stress, affects reversal learning and DRL performance following cocaine administration	7
Ligands of the trace amine-associated receptors (TAARs): A new class of anxiolytics	7
Alpha-pyrrolidinopentiothiophenone (α-PVT) activates the TLR–NF-κB–MAPK signaling pathway and proinflammatory cytokine production and induces behavioral sensitization in mice	7
Cocaine diminishes consolidation of cued fear memory in female rats through interactions with ventral hippocampal D2 receptors	7
Deciphering the gut microbiota's (Coprococcus and Subdoligranulum) impact on depression: Network pharmacology and molecular dynamics simulation	7
Sex-dependent and long-lasting effects of adolescent sleep deprivation on social behaviors in adult mice	7
Unlocking the age-old secrets of reward and substance use	7
Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex	7
Substance use disorder is the outcome of deviant socialization: A prospective investigation spanning childhood to adulthood	7
Editorial Board	7
The antidepressant agomelatine attenuates morphine-induced reinstatement but not self-administration or precipitated withdrawal	6
Differential patterns of opioid and dopamine D1 receptor antagonism on nutritive and non-nutritive sweetener intakes in C57BL/6:129 hybrid mice relative to inbred C57BL/6 and 129 mice	6
Pentylenetetrazole kindling induces dynamic changes in GAD65 expression in hippocampal somatostatin interneurons	6
The piperazine analogue para-fluorophenylpiperazine alters timing of the physiological effects of the synthetic cannabinoid receptor agonist AMB-FUBINACA, without changing its discriminative stimulus,	6
Unconventional anxiety pharmacology in zebrafish: Drugs beyond traditional anxiogenic and anxiolytic spectra	6
Editorial Board	6
Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress	6
The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders	6
Muscarinic M1, but not M4, receptor antagonism impairs divided attention in male rats	6
Practical opinions for new fiber photometry users to obtain rigorous recordings and avoid pitfalls	6
Interaction between cocaine use and sleep behavior: A comprehensive review of cocaine's disrupting influence on sleep behavior and sleep disruptions influence on reward seeking	6
The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 does not affect food intake in rats	6
Role of mGlu receptors in psychiatric disorders – Recent advances	6
ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice	6
Adolescent alcohol exposure modifies adult anxiety-like behavior and amygdala sensitivity to alcohol in rats: Increased c-Fos activity and sex-dependent microRNA-182 expression	6
SGK1.1 isoform is involved in nociceptive modulation, offering a protective effect against noxious cold stimulus in a sexually dimorphic manner	6
Swimming exercise reduces the vulnerability to stress and contributes to the AKT/GSK3β/CRMP2 pathway and microtubule dynamics mediated protective effects on neuroplasticity in male C57BL/6 mice	6
Ndufs4 KO mice: A model to study comorbid mood disorders associated with mitochondrial dysfunction	6
Age-related changes in CB1 receptor expression and function and the behavioral effects of cannabinoid receptor ligands	6
Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model	6
Context evoked morphine conditioned effects can be equivalent to morphine induced drug effects in terms of behavioral response and ERK activation in reward associated subcortical brain structures	6