Cell

Article	Citations
OLAH connects fatty acid metabolism to the severity of respiratory viral disease	4341
Response to: The information theory of aging has not been tested	2315
Muscle fusogens go viral for gene delivery to skeletal muscle	1308
A sound mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation	1262
Patterning by contraction	936
Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry	912
Mesoscopic mapping of the brain: From rodents to primates	909
In vitro human cell-based models: What can they do and what are their limitations?	895
The expanding world of neuroscience	894
RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly	825
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses	803
From periphery to center stage: 50 years of advancements in innate immunity	802
Bound by the love for cholesterol: A transporter meets a GPCR	783
Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses	768
Five decades of advances in cancer research	766
Keiji Tanaka (1949–2024)	759
Synthetic mammalian signaling circuits for robust cell population control	752
Shaping pit structure in vessel walls sustains xylem hydraulics and grain yield	745
Structure-based discovery of CFTR potentiators and inhibitors	672
Evolution and genetic adaptation of fishes to the deep sea	644
A metabolic balance of GLP-1 and NMDA receptors in the brain	611
Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk	601
Recycling of modified H2A-H2B provides short-term memory of chromatin states	594
Senescence-resistant human mesenchymal progenitor cells counter aging in primates	594
Channel synapse mediates neurotransmission of airway protective chemoreflexes	536

In vivo DNA replication dynamics unveil aging-dependent replication stress	530
Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells	518
Learning from HBCUs: How to produce Black professionals in STEMM	517
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias	512
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration	503
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution	498
CAR T therapy extends its reach to autoimmune diseases	497
Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite	495
Functional diversification of dietary plant small molecules by the gut microbiome	495
Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants	489
A pan-cancer analysis of the microbiome in metastatic cancer	480
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin	476
Choroid plexus mast cells drive tumor-associated hydrocephalus	473
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development	462
EBV and MS: The evidence is growing stronger	461
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain	446
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation	439
Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells	434
Deciphering breast cancer: from biology to the clinic	419
Structural specializations of the sperm tail	413
Structural basis for Cas9 off-target activity	408
Ovarian cancer-derived IL-4 promotes immunotherapy resistance	406
Interferons in health and disease	404
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center	402
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma	384
Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome	383
Local hyperthermia therapy induces browning of white fat and treats obesity	380
Structures of LRP2 reveal a molecular machine for endocytosis	365
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility	358
A deep learning strategy to identify cell types across species from high-density extracellular recordings	355
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex	349
Macrophages at the interface of the co-evolving cancer ecosystem	343
Genomic architecture of autism from comprehensive whole-genome sequence annotation	342
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic	336
Pursuing structural biology in China	333
Structure and infection dynamics of mycobacteriophage Bxb1	333
Structural basis of respiratory complex adaptation to cold temperatures	332
Propofol: Milk of Amnesia	328
Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine	324
SnapShot: Condensates in plant biology	320
Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease	320
Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding	318
Structurally divergent and recurrently mutated regions of primate genomes	309
Mechanism of IFT-A polymerization into trains for ciliary transport	308
Fungal sugars boost vaccine protection	304
To see is to experience: Aggression neurons light up when witnessing a fight	299
A gut-retching discovery	298
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition	297
How do DEI initiatives impact STEMM, and why do we still need them?	297
Precision medicine requires understanding how both sex and gender influence health	294

Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1	293
The information theory of aging has not been tested	291
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis	290
A mechano-resistance mechanism in skin adapts to terrestrial locomotion	286
It took a long, long time: Ras and the race to cure cancer	285
A genetic basis for sex differences in Xp11 translocation renal cell carcinoma	285
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity	284
Influence of autozygosity on common disease risk across the phenotypic spectrum	283
Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy	281
Cell surface fluctuations regulate early embryonic lineage sorting	280
Sleep is required to consolidate odor memory and remodel olfactory synapses	279
Multi-layered computational gene networks by engineered tristate logics	277
Ancient hybridization underlies tuberization and radiation of the potato lineage	276
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function	273
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration	271
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms	267
Gut-liver axis calibrates intestinal stem cell fitness	267
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals	265
The developmental basis of fingerprint pattern formation and variation	265
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients	262
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity	258
Central nervous system regeneration	258
DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs	254
Microglia maintain structural integrity during fetal brain morphogenesis	252
The first two blastomeres contribute unequally to the human embryo	244
Nutrition, longevity and disease: From molecular mechanisms to interventions	242
A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior	241
Spatial CRISPR genomics identifies regulators of the tumor microenvironment	241
Hallmarks of neurodegenerative diseases	241
Engineering RNA export for measurement and manipulation of living cells	237
A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement	233
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss	233
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification	232
Small-molecule hypoxia therapy in mitochondrial disease	232
Celebrating our origins with cell biology	231
ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs	228
Intracellular calcium release: A conductor of compartmentalized dendritic plasticity	227
Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network	225
Fine particle air pollution and lung cancer risk: Extending the long list of health risks	224
Freedom of expression: A synthetic route to metabolites	224
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia	222
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility	221
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming	220
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease	220
Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics	219
Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy	217
Immune checkpoint blockade provokes resident memory T cells to eliminate head and neck cancer	216
Engineered cell entry links receptor biology with single-cell genomics	215
Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs	212
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes	212
SnapShot: Cell size control	206
Multimodal charting of molecular and functional cell states via in situ electro-sequencing	205
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution	202
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs	201
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations	199
Root microbiota regulates tiller number in rice	197
An Arabidopsis single-nucleus atlas decodes leaf senescence and nutrient allocation	196
PIEZO2 in somatosensory neurons controls gastrointestinal transit	196
Small RNAs are modified with N-glycans and displayed on the surface of living cells	195
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes	194
Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape	192
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution	190
Open-ST: High-resolution spatial transcriptomics in 3D	189
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation	189
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin	188
Novel integrative elements and genomic plasticity in ocean ecosystems	188
Ultrafast distant wound response is essential for whole-body regeneration	187
A generative deep learning approach to de novo antibiotic design	187
Tracing the origin of alveolar stem cells in lung repair and regeneration	186
Virome characterization of game animals in China reveals a spectrum of emerging pathogens	186
TGF-β signaling in health and disease	185
Pathogen protein modularity enables elaborate mimicry of a host phosphatase	185
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays	184
Paul Berg and the origins of recombinant DNA	183
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy	182
Small STEPs toward a big change	181
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?	180
Mechanism of DNA capture by the MukBEF SMC complex and its inhibition by a viral DNA mimic	179
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration	177
Ancient host-associated microbes obtained from mammoth remains	176

Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions	176
Snapshot: Choroid plexus brain barrier	175
Chromosome-level organization of the regulatory genome in the Drosophila nervous system	174
Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT	173
Induced epigenetic changes memorized across generations in mice	173
Systematic profiling reveals betaine as an exercise mimetic for geroprotection	172
Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome	172
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic	171
ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors	171
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity	170
Overcoming drug resistance in cancer	170
Nothing about us without us: Sharing results with communities that provide genomic data	169
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans	169
Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases	169
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion	168
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling	168
Comparative landscape of genetic dependencies in human and chimpanzee stem cells	168
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture	168
A conserved family of immune effectors cleaves cellular ATP upon viral infection	167
The human proteome with direct physical access to DNA	165
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques	164
Designing antibodies as therapeutics	163
A widely distributed gene cluster compensates for uricase loss in hominids	163
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance	162
GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA	162
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors	162
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance	162
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates	161
Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection	161
Resmetirom for treatment of MASH	161
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway	160
Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution	159
A general chemical principle for creating closure-stabilizing integrin inhibitors	158
A multi-tissue metabolome atlas of primate pregnancy	158
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients	157
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures	157
Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin	157
Structural insights into auxin influx mediated by the Arabidopsis AUX1	156
The extracellular matrix integrates mitochondrial homeostasis	156
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant	156
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice	156
Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants	156
The genetic history of Scandinavia from the Roman Iron Age to the present	155
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity	154
ER stress transforms random olfactory receptor choice into axon targeting precision	154
Bispecific dendritic-T cell engager potentiates anti-tumor immunity	153
Atlas of the aging mouse brain reveals white matter as vulnerable foci	153
Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle	152
How to build the virtual cell with artificial intelligence: Priorities and opportunities	152
A neutrophil response linked to tumor control in immunotherapy	152
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment	151
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation	150
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes	149
Phage therapy: From biological mechanisms to future directions	148
Spatial proteomics in neurons at single-protein resolution	148
Jumbo phage killer immune system targets early infection of nucleus-forming phages	147
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins	147
Cancer neuroscience: State of the field, emerging directions	147
Human microglial state dynamics in Alzheimer’s disease progression	147
Intrinsic heterogeneity of primary cilia revealed through spatial proteomics	146
Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels	145
Macrophages in health and disease	144
Structural studies put phage defense mystery on the RADAR	143
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate	143
Seven days in the life cycle of Homo sapiens	143
Learning lessons from lipids to make COVID-19 vaccines	142
Problem choice and decision trees in science and engineering	142
Staphylococcus scratches its itch	142
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer	142
Harnessing social media to challenge scientific misinformation	142
Saturation mutagenesis-reinforced functional assays for disease-related genes	141
Medication effects on the gut microbiome in allo-HCT	140
A percolation phase transition controls complement protein coating of surfaces	140
Before you call the midwife	139
Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program	139
Global identification of SWI/SNF targets reveals compensation by EP400	139
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration	139
Mast cells regulate the brain-dura interface and CSF dynamics	139
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks	138
Transport mechanism and pharmacology of the human GlyT1	138
Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants	138
How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot	137
Opposing GPCR signaling programs protein intake setpoint in Drosophila	137
Human monoclonal antibodies targeting A35 protect from death caused by mpox	137
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors	135
Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development	135
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations	135
Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease	134
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development	133
Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer	132
Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women	132
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling	132
Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer	131
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability	131
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response	131