(The TQCC of Cell is 92. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)
Integrated analysis of multimodal single-cell data6946
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus3415
Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding1711
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-191481
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity1471
Adaptive immunity to SARS-CoV-2 and COVID-191374
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity1330
Hallmarks of aging: An expanding universe1288
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract1238
Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology1174
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera1133
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment1117
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells1104
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity1070
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes973
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications950
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera910
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant892
Mechanisms and disease consequences of nonalcoholic fatty liver disease885
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2860
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies830
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant818
The Global Phosphorylation Landscape of SARS-CoV-2 Infection815
Molecular Architecture of the SARS-CoV-2 Virus795
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity787
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses776
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2748
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers731
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic718
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade700
Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies691
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19664
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19656
Multiple early factors anticipate post-acute COVID-19 sequelae647
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells645
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase644
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin639
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy624
SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron615
Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2609
Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer609
Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum588
COVID-19-neutralizing antibodies predict disease severity and survival577
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19570
Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum556
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays555
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation551
Pan-Genome of Wild and Cultivated Soybeans547
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19545
Gut-microbiota-targeted diets modulate human immune status542
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants528
COVID-19 and the human innate immune system527
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein526
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome518
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition514
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease513
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS511
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas505
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity505
Antibody evasion by the P.1 strain of SARS-CoV-2501
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2497
Major Impacts of Widespread Structural Variation on Gene Expression and Crop Improvement in Tomato494
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma490
A Thermostable mRNA Vaccine against COVID-19486
A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice482
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies478
Effects of COVID-19 on the Nervous System476
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front472
High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue468
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells465
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses457
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2454
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19453
Genome engineering for crop improvement and future agriculture451
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera440
β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway438
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma432
Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2427
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma426
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches419
Emerging Pandemic Diseases: How We Got to COVID-19418
Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)417
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart415
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19414
Fibroblasts: Origins, definitions, and functions in health and disease412
The basic immunology of asthma412
The Polygenic and Monogenic Basis of Blood Traits and Diseases407
A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS407
Molecular topography of an entire nervous system393
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant392
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection392
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations386
The Self-Organizing Genome: Principles of Genome Architecture and Function385
Atherosclerosis: Recent developments385
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease384
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes383
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment383
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing382
The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease382
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors381
Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma378
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2377
Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution377
A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer373
Circular RNAs: Characterization, cellular roles, and applications371
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity366
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex359
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing352
Massive expansion of human gut bacteriophage diversity352
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis352
RNA-Mediated Feedback Control of Transcriptional Condensates349
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity349
Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer349
The origins of SARS-CoV-2: A critical review342
Bifidobacteria-mediated immune system imprinting early in life341
A Genetic Map of the Response to DNA Damage in Human Cells341
Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin337
TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy334
The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling333
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron332
The antigenic anatomy of SARS-CoV-2 receptor binding domain329
Functional characterization of the dural sinuses as a neuroimmune interface328
High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios326
SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape323
Hallmarks of neurodegenerative diseases322
Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear320
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses314
Humoral and cellular immune memory to four COVID-19 vaccines312
Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer312
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells311
The Human and Mouse Enteric Nervous System at Single-Cell Resolution311
Endometriosis: Etiology, pathobiology, and therapeutic prospects309
Integrative Proteomic Characterization of Human Lung Adenocarcinoma308
Adipose-tissue plasticity in health and disease306
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection306
Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein305
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis302
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction301
Spatially organized multicellular immune hubs in human colorectal cancer301
Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity301
Generation of Functional Human 3D Cortico-Motor Assembloids299
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks299
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy299
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor299
Small RNAs are modified with N-glycans and displayed on the surface of living cells294
A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model292
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection292
Spatiotemporal analysis of human intestinal development at single-cell resolution289
Multi-organ proteomic landscape of COVID-19 autopsies287
Telomeres: history, health, and hallmarks of aging287
Tackling COVID-19 with neutralizing monoclonal antibodies285
Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly284
The Rise of Molecular Glues283
The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation282
Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy281
Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate280
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression278
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies278
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins277
A route to de novo domestication of wild allotetraploid rice275
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients275
Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy274
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes272
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients270
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation269
Co-option of Neutrophil Fates by Tissue Environments266
Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb266
Microscopic examination of spatial transcriptome using Seq-Scope266
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination263
Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations263
Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality263
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response262
Proteogenomic characterization of pancreatic ductal adenocarcinoma262
Hallmarks of Health262
Cardioids reveal self-organizing principles of human cardiogenesis256
Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike254
Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment253
Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output253
Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States252
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine251
A Quantitative Proteome Map of the Human Body251
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2240
Circular RNA vaccines against SARS-CoV-2 and emerging variants240
Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution239
Nitric oxide signaling in health and disease238
Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses238
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer237
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis231
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity231
Mitocytosis, a migrasome-mediated mitochondrial quality-control process231
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies229
The Geometry of Abstraction in the Hippocampus and Prefrontal Cortex229
Pancreatic cancer: Advances and challenges229
Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy228
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway228
A single-cell atlas of chromatin accessibility in the human genome227
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome225
Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans225
Loss of epigenetic information as a cause of mammalian aging225
Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system222
Bacterial Retrons Function In Anti-Phage Defense221
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species221
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration221
Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition213
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses213
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19211
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition210
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis208
Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2208
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment207
Glioblastoma hijacks neuronal mechanisms for brain invasion207
Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells206
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer205
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq204
Spatially confined sub-tumor microenvironments in pancreatic cancer204
Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study203
Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response203
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells203
RNA promotes the formation of spatial compartments in the nucleus202
Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules201
The aging lung: Physiology, disease, and immunity200
Hallmarks of environmental insults199
BDNF signaling in context: From synaptic regulation to psychiatric disorders199
Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos198
Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation197
Cone-shaped HIV-1 capsids are transported through intact nuclear pores195
The expanding amyloid family: Structure, stability, function, and pathogenesis195
T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals194
Mapping transcriptomic vector fields of single cells193
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies193
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations192
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption192
A proteogenomic portrait of lung squamous cell carcinoma192
Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions192
Elevated rates of horizontal gene transfer in the industrialized human microbiome192
Massively parallel assessment of human variants with base editor screens191
The JAK-STAT pathway at 30: Much learned, much more to do190
Autism-related dietary preferences mediate autism-gut microbiome associations190
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact189
Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression189
Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity188
Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma188
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling188
An NK-like CAR T cell transition in CAR T cell dysfunction188
Immune checkpoint therapy—current perspectives and future directions187
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans186
Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic186
Glioma progression is shaped by genetic evolution and microenvironment interactions185
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion185
The long-term genetic stability and individual specificity of the human gut microbiome185