Cell

Article	Citations
Muscle fusogens go viral for gene delivery to skeletal muscle	5365
A sound mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation	2698
Bound by the love for cholesterol: A transporter meets a GPCR	1551
CAR T therapy extends its reach to autoimmune diseases	1097
Keiji Tanaka (1949–2024)	992
The expanding world of neuroscience	901
Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk	878
Response to: The information theory of aging has not been tested	865
From periphery to center stage: 50 years of advancements in innate immunity	840
OLAH connects fatty acid metabolism to the severity of respiratory viral disease	762
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation	757
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development	738
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin	719
Functional diversification of dietary plant small molecules by the gut microbiome	684
In vivo DNA replication dynamics unveil aging-dependent replication stress	642
Mesoscopic mapping of the brain: From rodents to primates	639
Structure-based discovery of CFTR potentiators and inhibitors	635
Learning from HBCUs: How to produce Black professionals in STEMM	632
Choroid plexus mast cells drive tumor-associated hydrocephalus	617
Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells	579
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic	577
Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry	577
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain	566
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility	556
Genomic architecture of autism from comprehensive whole-genome sequence annotation	531

Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses	528
Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome	526
RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly	517
Five decades of advances in cancer research	489
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses	485
Evolution and genetic adaptation of fishes to the deep sea	475
A metabolic balance of GLP-1 and NMDA receptors in the brain	474
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias	471
Recycling of modified H2A-H2B provides short-term memory of chromatin states	469
Genome instability triggers intercellular DNA transfer between human cells	468
Shaping pit structure in vessel walls sustains xylem hydraulics and grain yield	464
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis	453
Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells	449
Structures of LRP2 reveal a molecular machine for endocytosis	427
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center	414
Structural basis for Cas9 off-target activity	408
Channel synapse mediates neurotransmission of airway protective chemoreflexes	407
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma	406
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration	396
Can H5N1 avian influenza in dairy cattle be contained in the US?	389
Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants	387
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution	387
A pan-cancer analysis of the microbiome in metastatic cancer	386
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex	384
In vitro human cell-based models: What can they do and what are their limitations?	375
Structural specializations of the sperm tail	370
Interferons in health and disease	369
Senescence-resistant human mesenchymal progenitor cells counter aging in primates	364
EBV and MS: The evidence is growing stronger	363
Ovarian cancer-derived IL-4 promotes immunotherapy resistance	362
A deep learning strategy to identify cell types across species from high-density extracellular recordings	353
Deciphering breast cancer: from biology to the clinic	345
Macrophages at the interface of the co-evolving cancer ecosystem	342
Structure and infection dynamics of mycobacteriophage Bxb1	340
Pursuing structural biology in China	339
The first two blastomeres contribute unequally to the human embryo	333
Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018–2020 epidemic	330
Sleep is required to consolidate odor memory and remodel olfactory synapses	329
To see is to experience: Aggression neurons light up when witnessing a fight	325
How do DEI initiatives impact STEMM, and why do we still need them?	321
Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease	318
It took a long, long time: Ras and the race to cure cancer	314
Influence of autozygosity on common disease risk across the phenotypic spectrum	314
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity	309
A mechano-resistance mechanism in skin adapts to terrestrial locomotion	306
DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs	294
The evolution of high-order genome architecture revealed from 1,000 species	292
Multi-layered computational gene networks by engineered tristate logics	284
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss	283
Engineering RNA export for measurement and manipulation of living cells	280

Ancient hybridization underlies tuberization and radiation of the potato lineage	279
The developmental basis of fingerprint pattern formation and variation	278
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function	275
SnapShot: Condensates in plant biology	273
Planetary microbiome structure and generalist-driven gene flow across disparate habitats	268
Propofol: Milk of Amnesia	267
Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy	266
A genetic basis for sex differences in Xp11 translocation renal cell carcinoma	266
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity	265
Nuclear envelope budding enables export of large transcripts in muscle cells	261
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms	261
Predicting competition and substrate preferences for targeted microbiome alteration	259
Listening to the bladder field: Urine liquid biopsies reveal differential treatment responses in NMIBC	259
The information theory of aging has not been tested	259
Establishing the relationship between brain cellular senescence and brain structure	259
Gut-liver axis calibrates intestinal stem cell fitness	257
Structural basis of Wnt signalosome extracellular complex assembly	255
Uncovering spatially resolved functional genomics with CRISPR screen sequencing	255
Microglia maintain structural integrity during fetal brain morphogenesis	250
Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine	248
A gut-retching discovery	241
Structurally divergent and recurrently mutated regions of primate genomes	240
Structural basis of respiratory complex adaptation to cold temperatures	237
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1	237
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis	236
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration	234
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification	234
Mechanism of IFT-A polymerization into trains for ciliary transport	231
Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics	227
Hallmarks of neurodegenerative diseases	227
Celebrating our origins with cell biology	226
Multimodal charting of molecular and functional cell states via in situ electro-sequencing	226
Fine particle air pollution and lung cancer risk: Extending the long list of health risks	226
Small-molecule hypoxia therapy in mitochondrial disease	225
Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy	225
Striking a nerve: Sensory neurons orchestrate ECM remodeling and immune exclusion in TNBC	223
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility	223
ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs	221
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia	221
Pathogen protein modularity enables elaborate mimicry of a host phosphatase	219
SnapShot: Cell size control	217
A phytoscreen identifies a garlic compound as a deterrent of mating and egg laying in Drosophila and mosquitoes	213
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation	212
Small RNAs are modified with N-glycans and displayed on the surface of living cells	210
Spatial transcriptomics redraws the olfactory map	209
PIEZO2 in somatosensory neurons controls gastrointestinal transit	209
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations	206
Novel integrative elements and genomic plasticity in ocean ecosystems	206
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin	204
Root microbiota regulates tiller number in rice	201
A generative deep learning approach to de novo antibiotic design	200
An Arabidopsis single-nucleus atlas decodes leaf senescence and nutrient allocation	200
Immune checkpoint blockade provokes resident memory T cells to eliminate head and neck cancer	198
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution	196
Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs	196
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes	195
TGF-β signaling in health and disease	194
Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape	193
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease	192
Engineered cell entry links receptor biology with single-cell genomics	192
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes	191
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs	190
Tracing the origin of alveolar stem cells in lung repair and regeneration	190
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming	189
Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network	186
Open-ST: High-resolution spatial transcriptomics in 3D	185
Ultrafast distant wound response is essential for whole-body regeneration	185
Induced epigenetic changes memorized across generations in mice	185
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration	184
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?	184
Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT	183
Paul Berg and the origins of recombinant DNA	183
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates	183
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic	182
Mechanism of DNA capture by the MukBEF SMC complex and its inhibition by a viral DNA mimic	182
Nothing about us without us: Sharing results with communities that provide genomic data	182
Snapshot: Choroid plexus brain barrier	182
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice	181
Intrinsic heterogeneity of primary cilia revealed through spatial proteomics	181
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients	181

Whole-organ and whole-body 3D atlases enable cellome-wide profiling	180
The human proteome with direct physical access to DNA	179
Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle	179
A conserved family of immune effectors cleaves cellular ATP upon viral infection	179
Differential inhibition of Morbillivirus and Henipavirus polymerases by ERDRP-0519 and structure-guided inhibitor optimization	178
Jumbo phage killer immune system targets early infection of nucleus-forming phages	178
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture	178
A general chemical principle for creating closure-stabilizing integrin inhibitors	178
Comparative landscape of genetic dependencies in human and chimpanzee stem cells	178
The genetic history of Scandinavia from the Roman Iron Age to the present	178
Chromosome-level organization of the regulatory genome in the Drosophila nervous system	177
Systematic profiling reveals betaine as an exercise mimetic for geroprotection	177
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway	176
Development of non-spatial grid-like neural codes tracks inference and intelligence	176
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance	174
Bispecific dendritic-T cell engager potentiates anti-tumor immunity	172
Small STEPs toward a big change	172
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity	170
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans	170
A widely distributed gene cluster compensates for uricase loss in hominids	170
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling	168
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures	168
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors	167
A neutrophil response linked to tumor control in immunotherapy	167
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion	167
Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels	163
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation	163
Spatial proteomics in neurons at single-protein resolution	162
Overcoming drug resistance in cancer	162
Arbitrium phages can manipulate each other’s lysis/lysogeny decisions	162
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance	161
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity	161
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques	161
Bringing the genetically minimal cell to life on a computer in 4D	160
ER stress transforms random olfactory receptor choice into axon targeting precision	159
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy	159
Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature	158
Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin	158
Macrophages in health and disease	157
Cancer neuroscience: State of the field, emerging directions	156
The extracellular matrix integrates mitochondrial homeostasis	155
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment	155
Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants	155
Resmetirom for treatment of MASH	154
A multi-tissue metabolome atlas of primate pregnancy	154
Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution	153
Atlas of the aging mouse brain reveals white matter as vulnerable foci	152
Structural insights into auxin influx mediated by the Arabidopsis AUX1	152
Ancient host-associated microbes obtained from mammoth remains	152
Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection	151
Human microglial state dynamics in Alzheimer’s disease progression	148
Designing antibodies as therapeutics	148
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions	148
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate	147
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes	147
Phage therapy: From biological mechanisms to future directions	146
How to build the virtual cell with artificial intelligence: Priorities and opportunities	145
Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema	145
Medication effects on the gut microbiome in allo-HCT	143
Harnessing social media to challenge scientific misinformation	143
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer	143
Before you call the midwife	142
Transport mechanism and pharmacology of the human GlyT1	142
Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment	141
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors	141
Problem choice and decision trees in science and engineering	141
Hijacking ERAD for targeted degradation of transmembrane proteins	140
Staphylococcus scratches its itch	140
A circadian rheostat drives proton electrochemical gradients to optimize cell-type-specific growth in Arabidopsis	139
Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development	138
Saturation mutagenesis-reinforced functional assays for disease-related genes	138
p53 safeguards chemical reprogramming of human somatic cells toward pluripotency	137
AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology	137
Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes	136
Structural studies put phage defense mystery on the RADAR	135
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations	135
Opposing GPCR signaling programs protein intake setpoint in Drosophila	135
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development	135
Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program	135
STING signaling modulation by COPII cargo recognition	134
Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants	134
Integrative spatial analysis reveals a multi-layered organization of glioblastoma	134
Seven days in the life cycle of Homo sapiens	133
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response	133
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability	132
Bone marrow hematopoiesis drives multiple sclerosis progression	131
Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women	131
Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes	131
Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer	131
A percolation phase transition controls complement protein coating of surfaces	131
Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer	130
Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease	130
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks	129
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling	129
How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot	128