Seminars in Thrombosis and Hemostasis

Article	Citations
Cardiovascular and Thromboembolic Diseases in Oncology: Novel Aspects and Revisited Issues	55
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Protamine—The Journey from DNA to Heparin Neutralization to Gene therapy	44
Effects of Inflammation on Hemostasis in Acutely Ill Patients with Liver Disease	39
Cancer-Associated Thrombosis: Implications toward Health-Related Quality of Life	35
The Next, Next-Generation of Sequencing, Promising to Boost Research and Clinical Practice	31
Thrombosis in Antiphospholipid Syndrome: Current Perspectives and Challenges in Laboratory Testing for Antiphospholipid Antibodies	28
Thrombotic Antiphospholipid Syndrome and Direct Oral Anticoagulants: Unmet Needs and Review of the Literature	27
2021 Eberhard F. Mammen Award Announcements: Part II—Young Investigator Awards	26
Hemostatic Manifestations of Invasive Fungal Infections: A Comprehensive Review of Pathophysiological Mechanisms in Sepsis-Induced Hemostatic Disturbances, with a Focus on the Neonatal Population	26
Prevention of Venous Thromboembolism in Medical Patients with Thrombocytopenia or with Platelet Dysfunction: The Last 10 Years	25
Fright of Long-Haul Flights: Focus on Travel-Associated Thrombosis	24
Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases	24
Drug–Drug Interactions in the Treatment of Cancer-Associated Venous Thromboembolism with Direct Oral Anticoagulants	24
Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method	23
Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein: Comment	23
Cerebral Venous Thrombosis Developing after COVID-19 Vaccination: VITT, VATT, TTS, and More	22
Enhanced Half-Life Recombinant Factor VIII Concentrates for Hemophilia A: Final Results from Extension Studies	22
Platelet Activation and Thrombosis in COVID-19	22
Arterial Thrombosis in Cancer Patients: An Update	21
Platelet Function Testing: Update and Future Directions	21
Tissue Plasminogen Activator in Central Nervous System Physiology and Pathology: From Synaptic Plasticity to Alzheimer's Disease	21
Testing for Lupus Anticoagulants	20
Evolving Knowledge on Primary and Secondary Prevention of Venous Thromboembolism in Carriers of Hereditary Thrombophilia: A Narrative Review	19

Autoantibodies in Autoimmune Coagulation Factor Deficiencies: A Review of Inhibitory and Clearance-Accelerating Mechanisms from Japanese Practice	19
Fifty Years of Fibrinogen Structure and Function	19
Cardiovascular Mortality after Venous Thromboembolism: A Meta-Analysis of Prospective Cohort Studies	19
Editorial Compilation—XIII	19
Anti-platelet Factor 4 Antibody-Mediated Disorders: An Updated Narrative Review	18
Modulating Immune Responses: The Double-Edged Sword of Platelet CD40L	18
Gene Therapy for Hemophilia B: Achievements, Open Issues, and Perspectives	18
How Do Laboratories Perform von Willebrand Disease Diagnostics and Classification of von Willebrand Disease Patients? Results from External Quality Data and an International Survey	17
Erratum: Arterial Thrombosis in Patients with Antiphospholipid Syndrome: A Review and Meta-Analysis	17
Pulmonary Embolism in Patients with COVID-19: Comparison between Different Care Settings	17
The History of Rare Bleeding Disorders	17
Anti-Xa Monitoring of Low-Molecular-Weight Heparin during Pregnancy: A Systematic Review	16
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2022 Eberhard F. Mammen Award Announcements: Part I—Most Popular Articles	15
Cardiovascular and Thromboembolic Diseases in Oncology: Novel Aspects and Revisited Issues	15
Toward 50 Years of Seminars in Thrombosis and Hemostasis	15
Comprehensive Mendelian Randomization Analysis of Smoking and Its Effects on Venous Thromboembolism	15
Bernard–Soulier Syndrome: A Review of Epidemiology, Molecular Pathology, Clinical Features, Laboratory Diagnosis, and Therapeutic Management	14
Celebrating 50 Years of Seminars in Thrombosis and Hemostasis—Part III	14
Neurocoagulation from a Mechanistic Point of View in the Central Nervous System	14
Magnetic Resonance Screening for Cerebral Venous Sinus Thrombosis during Treatment with Pegaspargase	14
Association between Severe Acute Respiratory Syndrome Coronavirus 2 Infection (Coronavirus Disease 2019) and Lupus Anticoagulant-Hypoprothrombinemia Syndrome: A Case Report and Literature Assessment	14
50 Years of Pediatric Hemostasis: Knowledge, Diagnosis, and Treatment	13
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Investigating a Signal of Acquired Hemophilia Associated with COVID-19 Vaccination: A Systematic Case Review	13
From Ink Pens to Computers: A Personal Look Back at Landmark Changes during 5 Decades as a Clinical Laboratory Scientist in U.S. Hemostasis Laboratories	13
Strength of Anticoagulation in Moderate to Severe COVID-19 Illness: In Medio Stat Virtus?	12
Emicizumab in Type 3 von Willebrand Disease: Report of a Case with an Alloantibody and Literature Review	12
In Search of the Perfect Thrombosis and Bleeding-Associated Cancer Scale	12
Automation in Platelet Function Testing: Current Challenges and Future Directions	12
Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance	12
External Quality Assessment Data for Investigation of von Willebrand Disease: Focus on Relative Utility of Contemporary Functional von Willebrand Factor Assays. The United Kingdom National External Qu	12
The Growing Impact of Cardiovascular Oncology: Epidemiology and Pathophysiology	12
Mendelian Randomization Provides No Evidence for the Bidirectional Relationship between Type 2 Diabetes and Venous Thromboembolism in East Asians and African Americans	12
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Neutrophil Extracellular Traps: At the Interface of Thrombosis and Comorbidities	11
International Council for Standardization in Haematology Guidance for New Lot Verification of Coagulation Reagents, Calibrators, and Controls	11
Venous Thromboembolism in Children: The Rivaroxaban Experience	11
The Biological Significance of von Willebrand Factor O-Linked Glycosylation	11
Heparin-Like Anticoagulant: First Case Described in a Metastatic Biliopancreatic Cancer	11
Colchicine as a Modulator of Platelet Function: A Systematic Review	11
Gene Therapy in Hemophilia A: Achievements, Challenges, and Perspectives	11
Why “the Love of Blood” in Hemophilia?	11
A Brief History of Hemostasis and Thrombosis at the Mayo Clinic	11
Optimizing Venous Stenting: Consensus Recommendations for Enhanced Management of Lower Extremity Deep Vein Thrombosis	11
ROTEM Testing for Direct Oral Anticoagulants	11
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Tranexamic Acid and Its Potential Anti-Inflammatory Effect: A Systematic Review	10
A Historical Perspective on the Reversal of Anticoagulants	10
Risk Factors for Left Ventricular Thrombus Formation in Patients with Dilated Cardiomyopathy	10

Comparison of Platelet Function Tests for Long-Term Cardiovascular Events after Percutaneous Coronary Interventions	10
Bleeding Scoring Systems in Neonates: A Systematic Review	10
The Erythrocyte–ROS Axis in Thrombosis and Hemostasis	10
Editorial Compilation XIV	10
COVID-19 Vaccine-Associated Immune Thrombosis and Thrombocytopenia (VITT): Diagnostic Discrepancies and Global Implications	10
Impact of Hematocrit on Coagulation Measured by Rotational Thromboelastometry in Healthy Subjects and Patients with Polycythemia	10
Venous Thromboembolism Risk and Thromboprophylaxis in Pediatric Neurosurgery and Spinal Injury: Current Trends and Literature Review	10
Clinical, Laboratory, and Molecular Aspects of Factor V Deficiency	10
Mortality from Pulmonary Embolism in Patients with Post-Coronavirus Disease Syndrome	10
Dosing Intensity of Anticoagulants for the Prevention and Treatment of Venous Thromboembolism and the Prevention of Stroke in Atrial Fibrillation: Why is There a Difference?	10
Pulmonary Embolism-Related Mortality in Femur Fracture Patients: A Recent Retrospective Epidemiological Analysis	10
Editorial Compilation XI	9
The Pathophysiological Role of Platelet-Derived Extracellular Vesicles	9
Pleiotropic Effects of Heparin and its Monitoring in the Clinical Practice	9
A Perspective on How Fibrinaloid Microclots and Platelet Pathology May be Applied in Clinical Investigations	9
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Clinical Features of Antiphospholipid Syndrome with Intracardiac Mass	9
Platelet Physiology	9
Activated Partial Thromboplastin Time and Prothrombin Time Mixing Studies: Current State of the Art	9
Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature	9
Precision Medicine in Rare Bleeding Disorders	9
Cancer-Associated Thrombosis and Beyond: Biomarkers, Treatments, and Cancer-Hemostasis Interactions	9
Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)	9
The Applicability of Thromboelastography in Acute Ischemic Stroke: A Literature Review	9
Evaluating Diagnostic Algorithms for Heparin-Induced Thrombocytopenia using Two Combined Automated Rapid Immunoassays	9
Advances in the Management of Coagulopathy in Trauma: The Role of Viscoelastic Hemostatic Assays across All Phases of Trauma Care	8
Factor Replacement Treatment for Hemophilia A: Achievements and Perspectives	8
Thrombin Generation Assays: What are the Current Clinical Applications?	8
National Early Warning Score-2 for Identification of Patients with Intermediate-High-Risk Pulmonary Embolism	8
Increased HDL-C Values and Mortality: Revolutionizing a Historical Paradigm?	8
The Role of Platelets in Atherosclerosis: A Historical Review	8
Hemostasis Testing in the Emergency Department: A Narrative Review	8
Non-factor Therapies for Hemophilia: Achievements and Perspectives	8
Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein: Response to Comment	8
Emerging Use of Viscoelastography in Thrombosis and Hemostasis: A Challenge to Conventional Coagulation Tests? Part I: The Use of Thromboelastography and Thromboelastometry in the Assessment of Hemost	8
NETosis in Acute Thrombotic Disorders	8
Current Diagnosis of von Willebrand Disease in Italy: 3 Years Following the Release of the International Guidelines	8
Safety and Efficacy of Therapeutic Anticoagulation with Subcutaneous Unfractionated Heparin in Patients with Renal Failure	8
Crucial Stepping Stones in Platelet History	7
2022 Eberhard F. Mammen Award Announcements: Part II—Young Investigator Awards	7
One Hundred Years of Congenital Fibrinogen Disorders	7
Why Does Rivaroxaban Not Work in Severe Mitral Stenosis?	7
The More Recent History of Hemophilia Treatment	7
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Type 2A and 2M von Willebrand Disease: Differences in Phenotypic Parameters According to the Affected Domain by Disease-Causing Variants and Assessment of Pathophysiological Mechanisms	7
Evolution of Antiphospholipid Syndrome	7
PFA-100 System: A New Method for Assessment of Platelet Dysfunction	7
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Laboratory Testing for Fibrinogen Disorders: From Routine Investigations to Research Studies	7
Internal Quality Control in Hemostasis Assays	7
Laboratory Testing for ADAMTS13 for Thrombotic Thrombocytopenia Purpura and Beyond	7
D-dimers—“Normal” Levels versus Elevated Levels Due to a Range of Conditions, Including “D-dimeritis,” Inflammation, Thromboembolism, Disseminated Intravascular Coagulation, and COVID-19	7
Discordant High Activated Partial Thromboplastin Time Relative to Anti-Xa Values in Hospitalized Patients is an Independent Risk Factor for Increased 30-day Mortality	7
Next-Generation Sequencing and Emerging Technologies*	7
Application of Activators Ecarin and Factor Xa in Thrombelastography for Measurement of Anticoagulant Effect of Direct Oral Anticoagulants Using TEG 5000	7
Laboratory Evaluation of Antithrombin, Protein C, and Protein S	6
Clinical, Laboratory, and Molecular Aspects of Factor VII Deficiency	6
Factor VIII and Factor IX Activity Measurements for Hemophilia Diagnosis and Related Treatments	6
Advanced Treatment of Hemodynamically Unstable Acute Pulmonary Embolism and Clinical Follow-up	6
Risk Factors for Major Adverse Cardiovascular Events and Major Adverse Limb Events after Venous Thromboembolism: A Large Prospective Cohort Study	6
New Seminars in Thrombosis and Hemostasis (STH) 2021 Impact Factor, Most Highly Cited Papers, and Other Journal Metrics	6
Monitoring Hemostatic Function during Cardiac Surgery with Point-of-Care Viscoelastic Assays: A Narrative Review	6
Limb Ischemic Necrosis Secondary to Microvascular Thrombosis: A Brief Historical Review	6
Secondary Anticoagulation Use in Patients < 21 Years Old following Primary Anticoagulant Treatment for Provoked Venous Thromboembolism: Findings from the Kids-DOTT Trial	6
Nebulized Heparin in 2025: at the Interface between Promising Benefits and the Need for Further Research	6
Antiplatelet Therapy in Coronary Artery Disease: Now and Then	6
Hereditary Angioedema: The Clinical Picture of Excessive Contact Activation	6
Viscoelastic Management of Coagulopathy during the Perioperative Period of Liver Transplantation	6
Against Therapeutic Anticoagulation in Critically Ill COVID-19 Patients	6
Welcome to Seminars in Thrombosis & Hemostasis 2022	6
Comparison of Thrombophilia Assay Results for the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee Plasma Standard from Different External Quality Assessmen	6
Clinical, Laboratory Aspects and Management of Factor X Deficiency	6
Cellular Components Contributing to the Development of Venous Thrombosis in Patients with Pancreatic Cancer	6
Platelet Function in Acute Kidney Injury: A Systematic Review and a Cohort Study	6
Variable Performance of Lupus Anticoagulant Testing: The Australasian/Asia-Pacific Experience	5
The Benefits of Heparin Use in COVID-19: Pleiotropic Antiviral Activity beyond Anticoagulant and Anti-Inflammatory Properties	5
Is Lupus Anticoagulant a Significant Feature of COVID-19? A Critical Appraisal of the Literature	5
Cardiovascular Oncology: The Need for a Multidisciplinary Approach	5

Has “D-Dimeritis” Worsened during the Coronavirus Disease 2019 Pandemic?	5
Reviewing the Rich History of Fibrin Clot Research with a Focus on Clinical Relevance	5
Nonsevere Hemophilia: The Need for a Renewed Focus and Improved Outcomes	5
2023 Eberhard F. Mammen Award Announcements: Part II–Young Investigator Awards	5
Thrombosis Risk Assessment in Myeloproliferative Neoplasm—Is There a Role for Viscoelastic Testing?	5
Congenital Bleeding Disorders and COVID-19—A Systematic Literature Review	5
Efficacy and Safety of Antifibrinolytic Drugs in Pediatric Surgery: A Systematic Review	5
Dosing, Monitoring, Blood Product Utilization, and Thromboembolic Complications of Four-Factor Prothrombin Complex Concentrate as Part of an Institutional Protocol in Pediatric Cardiac Surgery: A Retr	5
Classification Criteria for the Antiphospholipid Syndrome: Not the Same as Diagnostic Criteria for Antiphospholipid Syndrome	5
Unlocking the Potential of MicroRNA Expression: Biomarkers for Platelet Reactivity and Coronary Artery Disease	5
Plasma Kallikrein as a Forgotten Clotting Factor	5
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A Novel Variant on the Thrombospondin Type-1 Repeat 2 Domain of ADAMTS13 in a Parturient with Suspected Hereditary Thrombotic Thrombocytopenic Purpura and Unusually High ADAMTS13 Activity	5
Deep Vein Thrombosis in Adults with HIV: A Systematic Review and Meta-analysis of Prevalence and Risk Factors	5
Risk Factors for Antiphospholipid Antibodies and Antiphospholipid Syndrome	5
Impact of Viral Infections on the Hemostatic System	5
Platelets in Vascular Calcification: A Comprehensive Review of Platelet-Derived Extracellular Vesicles, Protein Interactions, Platelet Function Indices, and their Impact on Cellular Crosstalk	5
Antiphospholipid Syndrome in Patients with Venous Thromboembolism	5
Antiphospholipid Antibodies in Pregnancy: Maternal and Neonatal Implications	5
Anticoagulation with Intravenous Direct Thrombin Inhibitors in Pediatric Extracorporeal Membrane Oxygenation: A Systematic Review of the Literature	5
The Pitfalls of Global Hemostasis Assays in Myeloproliferative Neoplasms and Future Challenges	5
Venous Thromboembolism after Hospital Discharge: Temporal Trends in Baseline Characteristics, Prevention, Treatment, and 90-day Outcomes	4
Risk Assessment Models for Thrombosis and Anticoagulant-Related Bleeding in Ambulatory Cancer Patients	4
What Role Does Microthrombosis Play in Long COVID?	4
The Role of Fibrin(ogen) in Wound Healing and Infection Control	4
Causal Associations Between Cardiovascular Risk Factors and Venous Thromboembolism	4
Cancer-Associated Splanchnic Vein Thrombosis	4
Measuring Quality of Life after Venous Thromboembolism: Who, When, and How?	4
Platelet Contributions to the (Pre)metastatic Tumor Microenvironment	4
Editorial Compilation XII	4
Is Vitamin D Deficiency Prothrombotic? A Systematic Review	4
Laser-Induced Blood Coagulation for Surgical Application: A Scoping Review	4
Epidemiology and Predisposing Factors of Post-COVID Venous Thrombosis: A Concise Review	4
A Critical Reappraisal of the Bleeding Time	4
Role of Circulating Microparticles in Type 2 Diabetes Mellitus: Implications for Pathological Clotting	4
Detecting Oxygenator Thrombosis in ECMO: A Review of Current Techniques and an Exploration of Future Directions	4
Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook	4
Mutations Accounting for Congenital Fibrinogen Disorders: An Update	4
The ABO Blood System and Associated Implications for Hemostasis and Thrombosis	4
Role of Viscoelastic and Conventional Coagulation Tests for Management of Blood Product Replacement in the Bleeding Patient	4
Editorial Compilation—XV	4
PKC-Delta-Dependent Pathways Contribute to the Exacerbation of the Platelet Activity in Crohn's Disease	4
Platelets: Physiology and Biochemistry	4
Heparins May Not Be the Optimal Anticoagulants for Sepsis and Sepsis-Associated Disseminated Intravascular Coagulation	4
Viscoelastic Testing in the Clinical Management of Subarachnoid Hemorrhage and Intracerebral Hemorrhage	4
Thrombosis in Pregnant Women with Hematological Malignancies: A Case-Based Review	4
Pathogen Reduction Technologies and Their Impact on Metabolic and Functional Properties of Treated Platelet Concentrates: A Systematic Review	4
Human Genetic Variation in F3 and Its Impact on Tissue Factor–Dependent Disease	4
Assessment of Hemostatic Profile in Neonates with Intrauterine Growth Restriction: A Systematic Review of Literature	4
Viscoelastic Hemostatic Assays in Sepsis: From Pathophysiology to Potential Clinical Implications	4
Correlation between Phenotype and Coagulation Factor Activity Level in Rare Bleeding Disorders: A Systematic Review	4
Causal Relationships of Circulating Inflammatory Proteins and Portal Vein Thrombosis: A Mendelian Randomization Study	4
Parathyroid Adenoma in a Young Girl with Type 3 von Willebrand Disease: Comment on “Cancers in Patients with von Willebrand Disease”	4
New Horizons in Fetal and Neonatal Alloimmune Thrombocytopenia	4
Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Se	4
The Evolution of Hemophilia Pharmacological Treatments and Therapeutic Targets at the Turn of the Third Millennium	3
Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-Term Mortality	3
Hemostasis, Thrombosis, and Vascular Biology in Psychiatric Disorders	3
Targeting the Contact Pathway of Coagulation for the Prevention and Management of Medical Device-Associated Thrombosis	3
Acquired Factor VII Deficiency Associated with Bronchogenic Carcinoma: A Case Report	3
Stability of Hemostasis Parameters in Whole Blood, Plasma, and Frozen Plasma: Literature Review and Recommendations of the SFTH (French Society of Thrombosis and Haemostasis)	3
Prone Position and the Risk of Venous Thrombosis in COVID-19 Patients with Respiratory Failure	3
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Post COVID-19 Large Vessel Vasculopathy in a Previously Healthy Young Male	3
Fibrin Network Porosity and Endo-/Exogenous Thrombin Cross-talk	3
A Case of Parturient with Hereditary Thrombotic Thrombocytopenic Purpura: Case Report of a Novel Variant	3
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Clinical Studies with Anticoagulants that Have Changed Clinical Practice	3
Diagnosis and Treatment of Autoimmune Acquired Coagulation Factor Deficiencies: An Evidence-Based Review of Japanese Practice	3
Hemostatic and Inflammatory Biomarkers are Associated with Functional Limitations after Venous Thromboembolism: A Prospective Cohort Study	3
Risk Factors of Catheter-Related Thrombosis in Elderly Patients with Lung Cancer Based on Thromboelastography: A Retrospective, Case-Control Study	3
Prediction of Recurrent Venous Thromboembolism and Arterial Cardiovascular Events after Discontinuation of Anticoagulation: The R-VTE-predict and MACE-predict Risk Scores	3
The Bleeding Time Test in 2024: A Glorious Past and Current Challenges	3
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Coronary Thrombosis with Distal Embolization in a Young Patient after Orthopaedic Surgery: An Informative Case Report	3
New Insights in Coagulation and Fibrinolysis in Patients with Primary Brain Cancer: A Systematic Review	3
Impact of Thrombosis and Bleeding in Patients with Severe COVID-19 versus Other Viral Pneumonias in the Context of Extracorporeal Membrane Oxygenation	3
Antiphospholipid Antibodies in Mental Disorders	3
Pearls and Pitfalls in the Measurement of Direct Oral Anticoagulants	3
COVID-19 Vaccine-Induced Immune Thrombosis with Thrombocytopenia (VITT) and the Shades of Grey in Thrombus Formation	3
Evolution of Hemostasis Testing: A Personal Reflection Covering over 40 Years of History*	3
Hereditary Angioedema and Venous Thromboembolism: Where There's Smoke, There's Fire	3
Involvement of Inflammation in Venous Thromboembolic Disease: An Update in the Age of COVID-19	3
Optimizing and Extending the Risk-Adapted Management of Acute Pulmonary Embolism beyond the Acute Phase: Progress in Pulmonary Embolism Research	3
From the Discovery of ADAMTS13 to Current Understanding of Its Role in Health and Disease	3
Evaluating Performance of Contemporary and Historical von Willebrand Factor (VWF) Assays in the Laboratory Identification of von Willebrand Disease (VWD): The Australasian Experience	3
Prophylaxis of Venous Thromboembolism in Children: A Systematic Review	3
Analysis of College of American Pathologists von Willebrand Factor Proficiency Testing Program	2
Blood Rheology and Hemodynamics: Still Illuminating after 20 Years	2
Gastrointestinal Bleeding in Congenital Bleeding Disorders	2
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Diagnostic Testing for von Willebrand Disease: Trends and Insights from North American Laboratories over the Last Decade	2
Analysis of College of American Pathologists von Willebrand Factor Proficiency Testing Program	2