OOIR: Observatory of International Research

Papers

(The TQCC of Brazilian Journal of Medical and Biological Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Bidirectional genetic selection of behaviors involved in social interaction of Wistar rats	47
Early introduction of exercise prevents insulin resistance in postnatal overfed rats	17
Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study	16
Anti-inflammatory, procollagen, and wound repair properties of topical insulin gel	15
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone	14
Nanosized copper particles induced mesangial cell toxicity via the autophagy pathway	13
ACE gene polymorphisms (rs4340) II and DI are more responsive to the ergogenic effect of caffeine than DD on aerobic power, heart rate, and perceived exertion in a homogeneous Brazilian group of adole	12
Unlocking the molecular realm: advanced approaches for identifying clinically and environmentally relevant bacteria	12
Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling	11
Cognitive behavioral stress management effectively facilitates neurologic recovery, alleviates mental distress, and elevates health status in acute ischemic stroke patients	11
Telomerase inhibitors TMPyP4 and thymoquinone decreased cell proliferation and induced cell death in the non-small cell lung cancer cell line LC-HK2, modifying the pattern of focal adhesion	10
Nutrition management by a multidisciplinary team for prevention of nutritional deficits and morbidity following esophagectomy	10
Erratum notice for: “Unlocking the molecular realm: advanced approaches for identifying clinically and environmentally relevant bacteria” [Braz J Med Biol Res 2023: 56, e12894]	10
GSK3B inhibition reduced cervical cancer cell proliferation and migration by modulating the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition	10
Reference equations of oxygen uptake for the step test in the obese population	9
Ovarian hormones influence immune response to liver ischemia-reperfusion	9
Erratum notice for: “Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways” [Braz J Med Biol Res 2020;53(2): e8793]	9
Barriers to patient recruitment in a poststroke neurorehabilitation multicenter trial in Brazil	9
Factors affecting executive function performance of Brazilian elderly in the Stroop test	9
Is near-infrared spectroscopy a promising predictor for early intracranial hemorrhage diagnosis in the Emergency Department?	8
Effects of N-butanol extract of Amygdalus mongolica on rats with bleomycin‐induced pulmonary fibrosis based on metabolomics	8
In vitro effects of lapachol and β-lapachone against Leishmania amazonensis	8
The role and mechanisms of cordycepin in inhibiting cancer cells	7
Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2	7
Didymin protects against polystyrene nanoplastic-induced hepatic damage in male albino rats by modulation of Nrf-2/Keap-1 pathway	7

Resveratrol as a cardioprotective adjuvant for 5-fluorouracil in the treatment of gastric cancer cells	7
Mental stress induces endothelial dysfunction by AT1R-mediated redox imbalance in overweight/obese men	7
The duration-dependent and sex-specific effects of neonatal sevoflurane exposure on cognitive function in rats	7
Validation of the online PREDICT tool in a cohort of early breast cancer in Brazil	7
Correlation of common inflammatory cytokines with cognition impairment, anxiety, and depression in acute ischemic stroke patients	7
Machine learning approaches and genetic determinants that influence the development of type 2 diabetes mellitus: a genetic association study in Brazilian patients	6
Prevalence and risk factors for falls among older Chinese adults in the community: findings from the CLHLS study	6
CAR-T therapy for gastrointestinal cancers: current status, challenges, and future directions	6
The essential role of adenine nucleotide translocase 4 on male reproductive function in mice	6
Neurocognitive effects of proanthocyanidin in Alzheimer's disease: a systematic review of preclinical evidence	6
Effects of imposed and self-selected exercise on perceptual and affective responses, muscle function, quality, and functionality of strength training in older women and men: a randomized trial	6
Quantifying lactulose and mannitol using LC-MS/MS in a clinical study of children with environmental enteric disease	5
Diagnostic value of serum inflammatory markers in predicting early refractoriness of transarterial chemoembolization in patients with Barcelona Clinic Liver Cancer Stage 0, A, and B hepatocellular car	5
Extraction and characterization of collagen from the skin of Amazonian freshwater fish pirarucu	5
A U-shaped relationship between sleep duration and tinnitus incidence: analysis of 13,871 participants from NHANES	5
Effect of propolis on Th2 and Th17 cells: interplay with EtxB- and LPS-treated dendritic cells	5
Giant uterine tumor and miscarriage: how to proceed?	5
Data-driven decision making for the screening of cognitive impairment in primary care: a machine learning approach using data from the ELSA-Brasil study	5
ITGBL1 transcriptionally inhibited by JDP2 promotes the development of pancreatic cancer through the TGF-beta/Smad pathway	5
Assessing the reaction to and efficacy of the Screener drug discovery and development board game as a pedagogical tool in postgraduate courses	5
Puerarin protects the fatty liver from ischemia-reperfusion injury by regulating the PI3K/AKT signaling pathway	5
Angiotensin receptor-neprilysin inhibitors and cardiac remodeling	5
Kidney health for all: bridging the gap in kidney health education and literacy	4
Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial	4
Self-reported carbohydrate supercompensation and supplementation strategies adopted by Olympic triathlon athletes	4
Upregulation of PGC-1α expression by pioglitazone mediates prevention of sepsis-induced acute lung injury	4
Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis	4
The LDL/HDL ratio predicts long-term risk of coronary revascularization in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: a cohort study	4
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor	4
Integrative analyses of genetic characteristics associated with skeletal endothelial cells	4
Genetic polymorphisms and protein levels in vocal fold leukoplakia: a systematic review	4
An overview on the current available treatment for COVID-19 and the impact of antibiotic administration during the pandemic	4
Luteolin ameliorates loperamide-induced functional constipation in mice	4
Study of the relationship between regional cerebral saturation and pCO2 changes during mechanical ventilation to evaluate modifications in cerebral perfusion in a newborn piglet model	4
Effect of different pacing strategies on 4-km cycling time trial performance	4
Synergy between isobavachalcone and doxorubicin suppressed the progression of anaplastic thyroid cancer through ferroptosis activation	4
Deoxycholic acid aggravates necrotizing enterocolitis through downregulation of mesenchymal-epithelial transition factor expression	4
Loneliness, spiritual well-being, and death perception, as well as their risk factors in urological cancer patients	4
Bioinformatic features and immunological response of recombinant antigen CTLA4-IgV-EgG1Y162 against Echinococcus granulosus	4
Saccharomyces boulardii supplementation does not affect anaerobic power gain induced by short-term sprint interval training in physically active individuals	3
Effect of COVID-19 on cardiorenal axis: known or unknown universe?	3
ZC3H12D upregulation in head and neck squamous cell carcinoma: a potential prognostic biomarker associated with immune infiltration	3
Acupuncture for generalized anxiety disorder: a study protocol for a randomized controlled trial	3
Circulating JKAP levels may correlate with postpartum anxiety and depression through its interaction with T helper 17 cells	3
The protective effect of melatonin supplementation against taxol-induced testicular cytotoxicity in adult rats	3
A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine	3
N-glycosylation of ACTRIIB enhances protein stability leading to rapid cell proliferation and strong resistance to docetaxel in nasopharyngeal carcinoma	3
FNDC5/Irisin in dementia and cognitive impairment: update and novel perspective	3
Investigations on the cytotoxicity and antimicrobial activities of terezine E and 14-hydroxyterezine D	3
Predictive value of DNA repair gene expression for response to neoadjuvant chemotherapy in breast cancer	3

Moderate physical exercise and ATP modulate the P2X7 receptor and improve cisplatin-induced gastric emptying delay in rats	3
Evaluation of oxidative stress markers in ethanol users	3
Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line	3
The role of the PKCζ/JNK signaling pathway in regulating the development of femoral head necrosis	3
Cortical thickness is related to working memory performance after non-invasive brain stimulation	3
A model for preservation of thymocyte-depleted thymus	3
Assessing multiple factors affecting the gut microbiome structure of very preterm infants	3
Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and myocardial ischemia responses of patients with HFpEF or HFmrEF	3
Genomic instability in long-term culture of human adipose-derived mesenchymal stromal cells	3
Serum levels of IL-12, IL-18, and IL-21 are indicators of viral load in patients chronically infected with HBV	3
Foxa1 mediates eccrine sweat gland development through transcriptional regulation of Na-K-ATPase expression	3
Systemic effects of oral tolerance improve the healing of several and concomitant wounds on different parts of the body	3
L-carnitine reduces acute lung injury via mitochondria modulation and inflammation control in pulmonary macrophages	2
Cellular consequences of small supernumerary marker chromosome derived from chromosome 12: mosaicism in daughter and father	2
Relaxation of thoracic aorta and pulmonary artery rings of marmosets (Callithrix spp.) by endothelium-derived 6-nitrodopamine	2
Erratum notice for: “microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9” [Braz J Med Biol Res 2021;54(4): e10345]	2
CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease	2
Apgar scores correlate with survival rate at discharge in extremely preterm infants with gestational age of 25-27 weeks	2
Aerobic capacity evaluation of Sprague Dawley rats in treadmill running: comparison between protocols	2
Presence of SARS-CoV-2 on food surfaces and public space surfaces in three districts of Lima, Peru	2
Osteogenic mechanism of deciduous teeth periodontal ligament stem cells in inflammatory environment	2
Changes of antioxidant enzymes in the kidney after cardiac arrest in the rat model	2
Factors associated with non-treatment of hypertension and gender differences at baseline in the ELSA-Brasil cohort	2
Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro	2
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats	2
Revealing induced pluripotent stem cells' potential as a better alternative to embryonic stem cells for Parkinson's disease treatment based on single-cell RNA-seq	2
Impact of angiotensin-converting enzyme inhibition on hemodynamic and autonomic profile of elastase-2 knockout mice	2
Nephroprotective effect of exercise training in cisplatin-induced renal damage in mice: influence of training protocol	2
PD-1 involvement in CD8+ tumor-infiltrating lymphocytes in patients with colonic-derived peritoneal adenocarcinoma	2
Potential biomarkers as a predictive factor of response to primary chemotherapy in breast cancer patients	2
The extent of involvement of ouabain, hippocampal expression of Na+/K+-ATPase, and corticosterone/melatonin receptors ratio in modifying stress-induced behavior differs according to the stressor in co	2
Sleep medicine and chronobiology education among Brazilian medical students	2
A real-world disproportionality analysis of cyclosporine from the FDA Adverse Event Reporting System (FAERS) database	2
Use of latex microbeads for detection of Plasmodium vivax lactate dehydrogenase using flow cytometry	2
Cardiometabolic risk factors and social jetlag in university professors	2
Features of lumbar spine texture extracted from routine MRI correlate with bone mineral density and can potentially differentiate patients with and without fragility fractures in the spine	2
Increased tumor-associated mast cells facilitate thyroid cancer progression by inhibiting CD8+ T cell function through galectin-9	2
Experimental study of local anesthetic and antiarrhythmic activities of fluorinated ethynylpiperidine derivatives	2
Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men	2
Toxic effects of Arianor Ebony hair dye on human cells	2
Relationship between resting augmentation index and spontaneous cardiac baroreflex sensitivity during handgrip exercise in postmenopausal women	2
Crescentic glomerulonephritis due to linear IgA anti-glomerular basement membrane disease: report of a rare case	2
Benzodiazepine partially reverses tonic-clonic seizures induced by thiocolchicoside	2
Nephrotic syndrome in the elderly: epidemiological aspects, clinical data, and renal biopsy findings	2
Clenbuterol and metformin ameliorate cachexia parameters, but only clenbuterol reduces tumor growth via lipid peroxidation in Walker 256 tumor-bearing rats	2
Isokinetic assessment of muscle function according to physical activity level and cardiovascular risk in asymptomatic adults aged 20 to 80 years	2
Convalescent plasma therapy in COVID-19 patients: a non-randomized case-control study with concurrent control	2
FRZB: a potential prognostic marker for head and neck squamous cell carcinoma	2
The potential of mRNA expression evaluation in predicting HER2 positivity in gastroesophageal cancer	2
PMEPA1 promotes gastric cancer cell proliferation by regulating the ubiquitin-mediated degradation of 14-3-3σ and promoting cell cycle progression	2
Dynactin knockdown leads to synuclein aggregation by blocking autophagy in a zebrafish model of Parkinson's disease	2
Effects of long-term metformin administration associated with high-intensity interval training on physical performance, glycogen concentration, GLUT-4 content, and NMR-based metabolomics in healthy ra	2
Control of sodium and potassium homeostasis by renal distal convoluted tubules	2
Efficacy of convalescent plasma in hospitalized COVID-19 patients: findings from a controlled trial	2
Does the early phase of aging affect the morphology of biceps brachii and torque and total work of elbow flexors in healthy volunteers?	2
Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model	2
AMPA and angiotensin type 1 receptors are necessary for hemorrhage-induced vasopressin secretion	2
Comparison of exploratory behavior of male and female woodlice (Armadillidium vulgare)	2
Erratum notice for: “NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway” [Braz J Med Biol Res 2019;52(1):7952]	2
Effects of traction therapy on atlantoaxial joint dislocation-induced cervical vertigo	2
Gastrodin plays a protective role in alleviating hepatic ischemia reperfusion injury by regulating heme oxygenase-1 expression	2
Coptisine ameliorates colitis in mice by modulating cPLA2/TRPM8/CGRP-1 signaling pathways and strengthening intestinal barrier function	2