OOIR: Observatory of International Research

Papers

(The TQCC of Brazilian Journal of Medical and Biological Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Telomerase inhibitors TMPyP4 and thymoquinone decreased cell proliferation and induced cell death in the non-small cell lung cancer cell line LC-HK2, modifying the pattern of focal adhesion	62
Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study	22
Bidirectional genetic selection of behaviors involved in social interaction of Wistar rats	22
Unlocking the molecular realm: advanced approaches for identifying clinically and environmentally relevant bacteria	21
Anti-inflammatory, procollagen, and wound repair properties of topical insulin gel	20
Early introduction of exercise prevents insulin resistance in postnatal overfed rats	16
Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone	16
Nanosized copper particles induced mesangial cell toxicity via the autophagy pathway	15
The dynamic changes in quantitative parameters of diffusion-weighted imaging at different b-values in a prostate cancer mouse model and their correlation with histopathology parameters	14
Cognitive behavioral stress management effectively facilitates neurologic recovery, alleviates mental distress, and elevates health status in acute ischemic stroke patients	14
ACE gene polymorphisms (rs4340) II and DI are more responsive to the ergogenic effect of caffeine than DD on aerobic power, heart rate, and perceived exertion in a homogeneous Brazilian group of adole	13
Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling	12
Effects of N-butanol extract of Amygdalus mongolica on rats with bleomycin‐induced pulmonary fibrosis based on metabolomics	12
Erratum notice for: “Unlocking the molecular realm: advanced approaches for identifying clinically and environmentally relevant bacteria” [Braz J Med Biol Res 2023: 56, e12894]	12
Prediction of early myocardial damage in obstructive sleep apnea patients using combined logistic regression and QUEST decision tree models	12
The role and mechanisms of cordycepin in inhibiting cancer cells	10
Is near-infrared spectroscopy a promising predictor for early intracranial hemorrhage diagnosis in the Emergency Department?	10
Reference equations of oxygen uptake for the step test in the obese population	10
Barriers to patient recruitment in a poststroke neurorehabilitation multicenter trial in Brazil	10
In vitro effects of lapachol and β-lapachone against Leishmania amazonensis	9
Ovarian hormones influence immune response to liver ischemia-reperfusion	9
Factors affecting executive function performance of Brazilian elderly in the Stroop test	9
The duration-dependent and sex-specific effects of neonatal sevoflurane exposure on cognitive function in rats	9
Evaluation of cytokine levels in HIV-infected individuals on therapy with tenofovir, lamivudine, and dolutegravir	9
Resveratrol as a cardioprotective adjuvant for 5-fluorouracil in the treatment of gastric cancer cells	9

Erratum notice for: “Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways” [Braz J Med Biol Res 2020;53(2): e8793]	9
Nutrition management by a multidisciplinary team for prevention of nutritional deficits and morbidity following esophagectomy	8
Didymin protects against polystyrene nanoplastic-induced hepatic damage in male albino rats by modulation of Nrf-2/Keap-1 pathway	8
GSK3B inhibition reduced cervical cancer cell proliferation and migration by modulating the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition	8
Correlation of common inflammatory cytokines with cognition impairment, anxiety, and depression in acute ischemic stroke patients	8
Validation of the online PREDICT tool in a cohort of early breast cancer in Brazil	7
Neurocognitive effects of proanthocyanidin in Alzheimer's disease: a systematic review of preclinical evidence	7
Machine learning approaches and genetic determinants that influence the development of type 2 diabetes mellitus: a genetic association study in Brazilian patients	7
CAR-T therapy for gastrointestinal cancers: current status, challenges, and future directions	7
Mental stress induces endothelial dysfunction by AT1R-mediated redox imbalance in overweight/obese men	7
Effects of imposed and self-selected exercise on perceptual and affective responses, muscle function, quality, and functionality of strength training in older women and men: a randomized trial	7
ITGBL1 transcriptionally inhibited by JDP2 promotes the development of pancreatic cancer through the TGF-beta/Smad pathway	7
The essential role of adenine nucleotide translocase 4 on male reproductive function in mice	7
Prevalence and risk factors for falls among older Chinese adults in the community: findings from the CLHLS study	7
Epidemiological and clinical factors of breast cancer in a population of mostly Afro-descendant women	7
Angiotensin receptor-neprilysin inhibitors and cardiac remodeling	6
Quantifying lactulose and mannitol using LC-MS/MS in a clinical study of children with environmental enteric disease	6
Extraction and characterization of collagen from the skin of Amazonian freshwater fish pirarucu	6
Giant uterine tumor and miscarriage: how to proceed?	6
Effect of propolis on Th2 and Th17 cells: interplay with EtxB- and LPS-treated dendritic cells	6
Self-reported carbohydrate supercompensation and supplementation strategies adopted by Olympic triathlon athletes	6
Effects of endurance exercise training on endoplasmic reticulum stress in pancreatic islets of obese mice	6
Puerarin protects the fatty liver from ischemia-reperfusion injury by regulating the PI3K/AKT signaling pathway	6
Diagnostic value of serum inflammatory markers in predicting early refractoriness of transarterial chemoembolization in patients with Barcelona Clinic Liver Cancer Stage 0, A, and B hepatocellular car	6
Unveiling immune mechanisms and potential biomarkers in intervertebral disc degeneration through integrated analysis	6
Synergy between isobavachalcone and doxorubicin suppressed the progression of anaplastic thyroid cancer through ferroptosis activation	6
Data-driven decision making for the screening of cognitive impairment in primary care: a machine learning approach using data from the ELSA-Brasil study	6
Trifolirhizin improves the hyperproliferation and excessive inflammatory response in human HaCaT keratinocytes and ameliorates skin lesions in psoriasis-like mouse models	6
Assessing the reaction to and efficacy of the Screener drug discovery and development board game as a pedagogical tool in postgraduate courses	6
Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2	6
A U-shaped relationship between sleep duration and tinnitus incidence: analysis of 13,871 participants from NHANES	6
Genetic polymorphisms and protein levels in vocal fold leukoplakia: a systematic review	6
Integrative analyses of genetic characteristics associated with skeletal endothelial cells	6
Effect of different pacing strategies on 4-km cycling time trial performance	5
An overview on the current available treatment for COVID-19 and the impact of antibiotic administration during the pandemic	5
Deoxycholic acid aggravates necrotizing enterocolitis through downregulation of mesenchymal-epithelial transition factor expression	5
Loneliness, spiritual well-being, and death perception, as well as their risk factors in urological cancer patients	5
Effect of COVID-19 on cardiorenal axis: known or unknown universe?	5
The body weight-walking distance product as a superior parameter in determining the VO2 on-kinetics in coronary artery disease	5
Luteolin ameliorates loperamide-induced functional constipation in mice	5
Effect of high-intensity childhood games on heart rate variability, saliva leptin concentrations, and body composition in children	5
Kidney health for all: bridging the gap in kidney health education and literacy	5
Upregulation of PGC-1α expression by pioglitazone mediates prevention of sepsis-induced acute lung injury	5
Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial	5
Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor	5
Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis	5
Bioinformatic features and immunological response of recombinant antigen CTLA4-IgV-EgG1Y162 against Echinococcus granulosus	5
Foxa1 mediates eccrine sweat gland development through transcriptional regulation of Na-K-ATPase expression	4
Assessing multiple factors affecting the gut microbiome structure of very preterm infants	4
Saccharomyces boulardii supplementation does not affect anaerobic power gain induced by short-term sprint interval training in physically active individuals	4

Study of the relationship between regional cerebral saturation and pCO2 changes during mechanical ventilation to evaluate modifications in cerebral perfusion in a newborn piglet model	4
FNDC5/Irisin in dementia and cognitive impairment: update and novel perspective	4
Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro	4
Moderate physical exercise and ATP modulate the P2X7 receptor and improve cisplatin-induced gastric emptying delay in rats	4
The protective effect of melatonin supplementation against taxol-induced testicular cytotoxicity in adult rats	4
Investigations on the cytotoxicity and antimicrobial activities of terezine E and 14-hydroxyterezine D	4
Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and myocardial ischemia responses of patients with HFpEF or HFmrEF	4
Cortical thickness is related to working memory performance after non-invasive brain stimulation	4
The LDL/HDL ratio predicts long-term risk of coronary revascularization in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: a cohort study	4
A model for preservation of thymocyte-depleted thymus	4
Acupuncture for generalized anxiety disorder: a study protocol for a randomized controlled trial	4
A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine	4
The role of the PKCζ/JNK signaling pathway in regulating the development of femoral head necrosis	4
N-glycosylation of ACTRIIB enhances protein stability leading to rapid cell proliferation and strong resistance to docetaxel in nasopharyngeal carcinoma	4
Chrysin induces cell death and inhibits migration and invasion in squamous cervical carcinoma using a three-dimensional cell culture model	4
ZC3H12D upregulation in head and neck squamous cell carcinoma: a potential prognostic biomarker associated with immune infiltration	4
Systemic effects of oral tolerance improve the healing of several and concomitant wounds on different parts of the body	4
Comparison of exploratory behavior of male and female woodlice (Armadillidium vulgare)	4
Genomic instability in long-term culture of human adipose-derived mesenchymal stromal cells	4
Efficacy of convalescent plasma in hospitalized COVID-19 patients: findings from a controlled trial	3
PMEPA1 promotes gastric cancer cell proliferation by regulating the ubiquitin-mediated degradation of 14-3-3σ and promoting cell cycle progression	3
Crescentic glomerulonephritis due to linear IgA anti-glomerular basement membrane disease: report of a rare case	3
Erratum notice for: “NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway” [Braz J Med Biol Res 2019;52(1):7952]	3
Use of latex microbeads for detection of Plasmodium vivax lactate dehydrogenase using flow cytometry	3
PD-1 involvement in CD8+ tumor-infiltrating lymphocytes in patients with colonic-derived peritoneal adenocarcinoma	3
Osteogenic mechanism of deciduous teeth periodontal ligament stem cells in inflammatory environment	3
The potential of mRNA expression evaluation in predicting HER2 positivity in gastroesophageal cancer	3
Factors associated with non-treatment of hypertension and gender differences at baseline in the ELSA-Brasil cohort	3
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats	3
Predictive value of DNA repair gene expression for response to neoadjuvant chemotherapy in breast cancer	3
Effects of traction therapy on atlantoaxial joint dislocation-induced cervical vertigo	3
CETP gene polymorphisms and haplotypes are explanatory variables for HDL cholesterol level in sickle cell disease	3
Effects of long-term metformin administration associated with high-intensity interval training on physical performance, glycogen concentration, GLUT-4 content, and NMR-based metabolomics in healthy ra	3
Revealing induced pluripotent stem cells' potential as a better alternative to embryonic stem cells for Parkinson's disease treatment based on single-cell RNA-seq	3
Metals, cardiovascular risk, and the interplay with oxidative stress: a mini-review	3
A real-world disproportionality analysis of cyclosporine from the FDA Adverse Event Reporting System (FAERS) database	3
Convalescent plasma therapy in COVID-19 patients: a non-randomized case-control study with concurrent control	3
Features of lumbar spine texture extracted from routine MRI correlate with bone mineral density and can potentially differentiate patients with and without fragility fractures in the spine	3
Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model	3
Serum levels of IL-12, IL-18, and IL-21 are indicators of viral load in patients chronically infected with HBV	3
Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line	3
Relationship between resting augmentation index and spontaneous cardiac baroreflex sensitivity during handgrip exercise in postmenopausal women	3
Cellular consequences of small supernumerary marker chromosome derived from chromosome 12: mosaicism in daughter and father	3
AMPA and angiotensin type 1 receptors are necessary for hemorrhage-induced vasopressin secretion	3
Apgar scores correlate with survival rate at discharge in extremely preterm infants with gestational age of 25-27 weeks	3
Does the early phase of aging affect the morphology of biceps brachii and torque and total work of elbow flexors in healthy volunteers?	3
Erratum notice for: “microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9” [Braz J Med Biol Res 2021;54(4): e10345]	3
Aerobic capacity evaluation of Sprague Dawley rats in treadmill running: comparison between protocols	3
The extent of involvement of ouabain, hippocampal expression of Na+/K+-ATPase, and corticosterone/melatonin receptors ratio in modifying stress-induced behavior differs according to the stressor in co	3
Experimental study of local anesthetic and antiarrhythmic activities of fluorinated ethynylpiperidine derivatives	3
Toxic effects of Arianor Ebony hair dye on human cells	3
Evaluation of oxidative stress markers in ethanol users	3
Circulating JKAP levels may correlate with postpartum anxiety and depression through its interaction with T helper 17 cells	3