Immunological Reviews

Article	Citations
Issue Information	287
Antigen‐specific and cross‐reactive T cells in protection and disease	242
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	171
Immune checkpoint inhibitors in infectious disease	108
Bridging pDCs and cDCs : The Identity of Transitional Dendritic Cells	107
Cover Image	107
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	103
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	98
NETosis: Sculpting tumor metastasis and immunotherapy	93
Metabolic regulation of type I interferon production	87
Superoxide: The enigmatic chemical chameleon in neutrophil biology	85
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	83
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	81
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	79
Role of inflammasomes and neuroinflammation in epilepsy	76
Issue Information	73
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	72
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	71
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	69
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	68
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	62
Mechanisms Promoting Stability of B Cells	60
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	58
Layered origins of lymphoid tissue inducer cells	57
With complements: C3 inhibition in the clinic	57

The immune system in Down Syndrome: Autoimmunity and severe infections	55
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	51
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	51
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	51
Autoimmunity and the microbiome	50
Maternal influences on offspring food allergy	49
Cover Image	48
Functional Insights From Immunoreceptor Structures	47
Issue Information	47
Common variable immunodeficiency, cross currents, and prevailing winds	46
An introduction to neuroimmunology	45
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Issue Information	44
Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes	44
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	43
Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	42
Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases*	42
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	42
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	42
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	41
Issue Information	41
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	39
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	39
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	39
Human neutrophils ≠ murine neutrophils: Does it matter?	38
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	38
Glycobiology of IgE	38
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	37
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	37
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	37
Modulation of immunity by the secreted phospholipase A2 family	37
Axes of heterogeneity in human tissue‐resident memory T cells	37
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	37
PANoptosis: Mechanisms, biology, and role in disease	36
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Cover Image	34
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	33
Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis	33
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	32
Structural Immunology of SARS‐CoV‐2	32
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	32
From Lymphotoxin to Tertiary Lymphoid Structures and Beyond	32
Factor D	31
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	31
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	31
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	31
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	31
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Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	30

Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	30
Host immune responses in the central nervous system during fungal infections	30
Irritable bowel syndrome: When food is a pain in the gut	30
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	29
Many Achilles’ heels of B and T cell tolerance	29
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	29
Development and organization of omental milky spots	29
Issue Information	29
Cover Image	28
Cover Image	28
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	27
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	27
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	26
No time to die: Epigenetic regulation of natural killer cell survival	26
Innate Immunity and Asthma Exacerbations: Insights From Human Models	26
Stability and change in epigenetic regulation of immune cells	25
Neutrophils in aging and aging‐related pathologies	25
Human Atypical B Cells. An Overview	25
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	25
Low‐molecular weight inhibitors of the alternative complement pathway	25
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	25
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	25
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	25
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	24
Issue Information	24
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Issue Information	24
Swimming Through Dendritic Cell Biology: Insights From Fish Models	23
Ontogenetic Diversification of Type 2 Conventional Dendritic Cells in the Bone Marrow: A Central Logic for Peripheral Immunity	23
The nervous system during COVID‐19: Caught in the crossfire	23
ILC2 Diversity, Location, and Function in Pulmonary Disease	23
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Issue Information	22
The impact of the human gut microbiome on the treatment of autoimmune disease	22
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The impact of neuroinflammation on neuronal integrity	22
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	22
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	21
Innate Immune Sensors in Health and Disease	21
Signals that control MAIT cell function in healthy and inflamed human tissues	21
Established and emerging roles for mitochondria in neutrophils	21
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	21
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	20
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	20
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	20
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	20
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	20
Thymic Dendritic Cells Revisited	20
Microbes and the fate of neutrophils	19
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Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	19
Life‐threatening antibodies: The discovery of anaphylaxis	19
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Imaging the immune system redux	19
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	18
Dendritic Cells in the Gastrointestinal System: Division of Labor, Plasticity, and Niche‐Specific Adaptation	18
Regulation of immune responses to food by commensal microbes	18
Copper homeostasis and cuproptosis in cancer immunity and therapy	18
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	18
Mechanosensing in Dendritic Cells	18
Additional Cover	18
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	18
Role of B cells in immune‐related adverse events following checkpoint blockade	18
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	18
Small matters: Introduction to extracellular vesicles	17
Introductory article for Immunological Reviews, Vol 310	17
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases	17
CD4 T cells and toxicity from immune checkpoint blockade	16
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer	16
Cover Image	16
The Immunology of Alpha‐Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat	16
Correction to “The Integrin Receptors: From Discovery to Structure to Medicines”	16
The role of dysregulated PI3Kdelta signaling in human autoimmunity*	16
The emergence of the calvarial hematopoietic niche in health and disease	16
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*	16
Antibodies against endogenous retroviruses	16
Severe combined immunodeficiency diagnosis and genetic defects	16
Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19	15
Whence and wherefore IgE?	15
The susceptibility of the kidney to alternative pathway activation—A hypothesis	15

Intersection of the microbiome and immune metabolism in lupus	15
Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis	15
Epitope‐Specific Antibodies in Allergic Disease and Clinical Tolerance	15
Physiology and pathology of the C3 amplification cycle: A retrospective	15
Issue Information	15
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A Brief Molecular History of Vγ9Vδ2 TCR ‐Mediated Phosphoantigen Sensing	15
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	14
Issue Information	14
Issue Information	14
My story of sex, gender, and women's health in a pandemic*	14
Low‐density granulocytes in systemic autoimmunity and autoinflammation	14
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	14
Living in LALA land? Forty years of attenuating Fc effector functions	14
Stress/cell death pathways, neuroinflammation, and neuropathic pain	14
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	14
Molecular determinants of immunogenic cell death elicited by radiation therapy	14
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	13
Current knowledge on the early stages of human neutropoiesis	13
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	13
The Sunrise of Tertiary Lymphoid Structures in Cancer	13
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	13
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	13
The resolution of phagosomes	13
Age‐related macular degeneration: A disease of extracellular complement amplification	13
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	13
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	13
AIRE's Complex Role Beyond Promiscuous Gene Expression	13
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	13
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	13
Maternal IgE Influence on Fetal and Infant Health	12
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An Outside‐In View of the Beneficial and Detrimental Impact of Type‐2 Inflammation in the Lung	12
Unique aspects of IFN‐γ/STAT1 signaling in neurons	12
Early life imprinting of intestinal immune tolerance and tissue homeostasis	12
Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	12
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	12
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	12
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	12
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	12
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	12
Coordinated Regulation of Extrafollicular B Cell Responses by IL ‐12 and IFN γ	12
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Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	12
Engineered exosomes for studies in tumor immunology	12
C3‐dependent effector functions of complement	12
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	12
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	11
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	11
Functional neutrophil disorders: Chronic granulomatous disease and beyond	11
IgE in Allergic Diseases	11
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	11
Apoptotic cell clearance components in inflammatory arthritis	11
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	11
Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens	11
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	11
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The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch	10
Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies	10
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Pyroptosis in glioma: Current management and future application	10
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	10
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Decoding immunogenic cell death from a dendritic cell perspective	10
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	10
The complement alternative pathway in health and disease—activation or amplification?	10
Maternal‐driven immune education in offspring	10
Type I interferon and cancer	10
The Factor H protein family: The switchers of the complement alternative pathway	10
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	10
Gene therapy for adenosine deaminase severe combined immune deficiency—An unexpected journey of four decades	10
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation	10
The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets	10
Issue Information	10
The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms	9
Thymic Mimetic Cells: Evolutionarily Ancient Mirrors of the Periphery	9
Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies	9
Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment	9
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A newborn's perspective on immune responses to food	9
Small particles with large impact: Insights into the unresolved roles of innate immunity in extracellular vesicle‐mediated cardiovascular calcification	9
Mechanisms for initiation of food allergy by skin pre‐disposed to atopic dermatitis	9
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The role of exosomes in cancer‐related programmed cell death	9
Transcriptional and hormonal control of adipose Treg heterogeneity and function	9
Primary and secondary defects of the thymus	9
Intracellular complement: Evidence, definitions, controversies, and solutions	9
Targeting ferroptosis in gastric cancer: Strategies and opportunities	9
Issue Information	9
The layered development of mouse B and T Cells	9
Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism	9
Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity	9
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The neutrophil: A key resourceful agent in immune‐mediated vasculitis	8
Memories that last: Dynamics of memory T cells throughout the body	8