Immunological Reviews

Article	Citations
Issue Information	260
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	229
Cover Image	177
Immune checkpoint inhibitors in infectious disease	124
Antigen‐specific and cross‐reactive T cells in protection and disease	109
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	91
Imaging dendritic cell functions*	76
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	75
Metabolic regulation of type I interferon production	75
Superoxide: The enigmatic chemical chameleon in neutrophil biology	69
Role of inflammasomes and neuroinflammation in epilepsy	65
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	65
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	64
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	62
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	58
NETosis: Sculpting tumor metastasis and immunotherapy	57
Issue Information	56
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	55
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	54
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	52
With complements: C3 inhibition in the clinic	51
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	50
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	50
The immune system in Down Syndrome: Autoimmunity and severe infections	50
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	48

Layered origins of lymphoid tissue inducer cells	48
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	48
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	43
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	42
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Cover Image	40
An introduction to neuroimmunology	40
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	40
Autoimmunity and the microbiome	38
Maternal influences on offspring food allergy	37
Issue Information	37
Issue Information	37
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Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases*	36
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	36
Sequence determinants as key regulators in gene expression of T cells	36
ZAP70, too little, too much can lead to autoimmunity*	35
Common variable immunodeficiency, cross currents, and prevailing winds	35
Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	35
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	35
Issue Information	34
Functional Insights From Immunoreceptor Structures	34
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	34
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	34
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	33
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	32
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	32
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	31
Modulation of immunity by the secreted phospholipase A2 family	31
Axes of heterogeneity in human tissue‐resident memory T cells	30
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	30
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	30
Human neutrophils ≠ murine neutrophils: Does it matter?	30
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	29
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	29
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	29
PANoptosis: Mechanisms, biology, and role in disease	29
Glycobiology of IgE	29
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	28
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Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	28
Structural Immunology of SARS‐CoV‐2	28
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	28
Cover Image	27
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	27
Factor D	27
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	27
Irritable bowel syndrome: When food is a pain in the gut	26
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Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	25

Development and organization of omental milky spots	25
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	25
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	25
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	25
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	24
Issue Information	24
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	24
Cover Image	24
Host immune responses in the central nervous system during fungal infections	24
Many Achilles’ heels of B and T cell tolerance	24
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	24
Transcriptional and epigenetic regulation in thymic epithelial cells*	23
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	23
No time to die: Epigenetic regulation of natural killer cell survival	23
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	23
Low‐molecular weight inhibitors of the alternative complement pathway	23
Cover Image	23
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	23
Stability and change in epigenetic regulation of immune cells	22
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	22
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	22
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	21
Issue Information	21
Neutrophils in aging and aging‐related pathologies	21
Issue Information	21
Innate Immunity and Asthma Exacerbations: Insights From Human Models	21
The nervous system during COVID‐19: Caught in the crossfire	20
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	20
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ILC2 Diversity, Location, and Function in Pulmonary Disease	19
The impact of neuroinflammation on neuronal integrity	19
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	19
Visualization and functional characterization of lymphoid organ fibroblasts*	19
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	19
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The impact of the human gut microbiome on the treatment of autoimmune disease	19
Regnase‐1–related endoribonucleases in health and immunological diseases	19
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	18
Microbes and the fate of neutrophils	18
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	18
Signals that control MAIT cell function in healthy and inflamed human tissues	18
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Established and emerging roles for mitochondria in neutrophils	18
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	18
Imaging leukocyte migration through afferent lymphatics*	18
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	18
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	18
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	17
Innate Immune Sensors in Health and Disease	17
Issue Information	17
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	17
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	16
Additional Cover	16
Imaging the immune system redux	16
Regulation of immune responses to food by commensal microbes	16
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Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	16
Role of B cells in immune‐related adverse events following checkpoint blockade	16
Life‐threatening antibodies: The discovery of anaphylaxis	16
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	16
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	16
Small matters: Introduction to extracellular vesicles	15
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CD4 T cells and toxicity from immune checkpoint blockade	15
The role of dysregulated PI3Kdelta signaling in human autoimmunity*	15
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	15
Introductory article for Immunological Reviews, Vol 310	15
What sequencing technologies can teach us about innate immunity*	15
Cover Image	15
Copper homeostasis and cuproptosis in cancer immunity and therapy	15
Antibodies against endogenous retroviruses	15
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*	15
The emergence of the calvarial hematopoietic niche in health and disease	15
The Immunology of Alpha‐Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat	14
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer	14
Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis	14
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*	14
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The susceptibility of the kidney to alternative pathway activation—A hypothesis	13
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases	13

Severe combined immunodeficiency diagnosis and genetic defects	13
Low‐density granulocytes in systemic autoimmunity and autoinflammation	13
Issue Information	13
My story of sex, gender, and women's health in a pandemic*	13
Living in LALA land? Forty years of attenuating Fc effector functions	12
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	12
Epitope‐Specific Antibodies in Allergic Disease and Clinical Tolerance	12
Whence and wherefore IgE?	12
Molecular determinants of immunogenic cell death elicited by radiation therapy	12
Intersection of the microbiome and immune metabolism in lupus	12
Stress/cell death pathways, neuroinflammation, and neuropathic pain	12
Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19	12
A Brief Molecular History of Vγ9Vδ2 TCR‐Mediated Phosphoantigen Sensing	12
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	11
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	11
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	11
Age‐related macular degeneration: A disease of extracellular complement amplification	11
Spatial determinates of effector and memory CD8+ T cell fates*	11
Issue Information	11
Current knowledge on the early stages of human neutropoiesis	11
The resolution of phagosomes	11
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	11
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	11
The Sunrise of Tertiary Lymphoid Structures in Cancer	11
Physiology and pathology of the C3 amplification cycle: A retrospective	11
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	11
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	11
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	11
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	11
Epigenetics and CD8+ T cell memory*	11
Issue Information	11
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	10
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	10
Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	10
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	10
Maternal IgE Influence on Fetal and Infant Health	10
Unique aspects of IFN‐γ/STAT1 signaling in neurons	10
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	10
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	10
Early life imprinting of intestinal immune tolerance and tissue homeostasis	10
C3‐dependent effector functions of complement	10
An Outside‐In View of the Beneficial and Detrimental Impact of Type‐2 Inflammation in the Lung	10
Engineered exosomes for studies in tumor immunology	10
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Eras of designer Tregs: Harnessing synthetic biology for immune suppression	10
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	10
How RNA modifications regulate the antiviral response	10
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	10
Coordinated Regulation of Extrafollicular B Cell Responses by IL‐12 and IFNγ	10
The Factor H protein family: The switchers of the complement alternative pathway	9
The special unfolded protein response in plasma cells	9
The complement alternative pathway in health and disease—activation or amplification?	9
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	9
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	9
Heterogeneity in antiviral B cell responses: Lessons from the movies*	9
Functional neutrophil disorders: Chronic granulomatous disease and beyond	9
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	9
Maternal‐driven immune education in offspring	9
Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies	9
The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch	9
Regulation of airway immunity by epithelial miRNAs	9
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	9
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	9
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	9
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The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets	9
Information flow in the spatiotemporal organization of immune responses*	9
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	9
Apoptotic cell clearance components in inflammatory arthritis	9
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Gene therapy for adenosine deaminase severe combined immune deficiency—An unexpected journey of four decades	9
Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism	8
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	8
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation	8
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The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms	8
Targeting ferroptosis in gastric cancer: Strategies and opportunities	8
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	8
Decoding immunogenic cell death from a dendritic cell perspective	8
Issue Information	8
A newborn's perspective on immune responses to food	8
Small particles with large impact: Insights into the unresolved roles of innate immunity in extracellular vesicle‐mediated cardiovascular calcification	8
Epigenetic regulation of natural killer cell memory*	8
Pyroptosis in glioma: Current management and future application	8
Type I interferon and cancer	8
Issue Information	8
Transcriptional and hormonal control of adipose Treg heterogeneity and function	8
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Intracellular complement: Evidence, definitions, controversies, and solutions	8
Tissue‐resident memory T cells and lung immunopathology	7
The role of exosomes in cancer‐related programmed cell death	7
Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*	7
Mechanisms for initiation of food allergy by skin pre‐disposed to atopic dermatitis	7
Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines	7