Immunological Reviews

Article	Citations
Issue Information	309
Cover Image	260
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	251
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	138
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	129
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	125
Bridging pDCs and cDCs : The Identity of Transitional Dendritic Cells	124
NETosis: Sculpting tumor metastasis and immunotherapy	121
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	110
Antigen‐specific and cross‐reactive T cells in protection and disease	109
The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ	107
In Defense of Homeostasis: Innate Immunity in Cardiac Injury and Repair	94
Reframing Thymic Biology: From AIRE to Mimetics, Thymflammation, Regeneration, and Beyond	92
Immune checkpoint inhibitors in infectious disease	83
Superoxide: The enigmatic chemical chameleon in neutrophil biology	82
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	78
Role of inflammasomes and neuroinflammation in epilepsy	76
Metabolic regulation of type I interferon production	74
Issue Information	73
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	69
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	69
Layered origins of lymphoid tissue inducer cells	67
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	64
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	60
Mechanisms Promoting Stability of B Cells	59

Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	59
The immune system in Down Syndrome: Autoimmunity and severe infections	58
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	57
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	56
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	56
With complements: C3 inhibition in the clinic	55
Maternal influences on offspring food allergy	55
Cover Image	55
An introduction to neuroimmunology	54
Functional Insights From Immunoreceptor Structures	54
Issue Information	54
Common variable immunodeficiency, cross currents, and prevailing winds	53
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	52
	49
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	48
Issue Information	48
	48
Artery Tertiary Lymphoid Organs Form Neuroimmune Cardiovascular Interfaces in Atherosclerosis	47
Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	46
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	46
Immune Mechanisms of Viral, Autoimmune, and Immune Checkpoint Inhibitor‐Associated Myocarditis	46
Sex Differences in Asthma Pathogenesis	45
Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes	45
Autoimmunity and the microbiome	45
Sex Differences in Lung Immunity	45
Issue Information	44
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	43
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	43
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	43
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	43
Glycobiology of IgE	42
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	42
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	41
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	41
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	41
Human neutrophils ≠ murine neutrophils: Does it matter?	41
PANoptosis: Mechanisms, biology, and role in disease	41
Modulation of immunity by the secreted phospholipase A2 family	40
Axes of heterogeneity in human tissue‐resident memory T cells	40
	40
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	39
Cover Image	39
Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis	38
Factor D	38
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	37
	36
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	36
From Lymphotoxin to Tertiary Lymphoid Structures and Beyond	36
Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures	36
Structural Immunology of SARS‐CoV‐2	36

	35
Host immune responses in the central nervous system during fungal infections	33
Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design	33
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	33
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	32
Irritable bowel syndrome: When food is a pain in the gut	32
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	32
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	31
Development and organization of omental milky spots	31
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	30
The X Factor in Immunity: Sex Differences Shaped by the X Chromosome	30
Cover Image	29
Issue Information	29
Cover Image	29
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	29
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	28
Low‐molecular weight inhibitors of the alternative complement pathway	28
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	28
Biology of IgE	28
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	28
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	27
Innate Immunity and Asthma Exacerbations: Insights From Human Models	27
Type 2 IgG Memory B Cells and Long‐Lived IgE Plasma Cells in the Persistence of Allergy	27
No time to die: Epigenetic regulation of natural killer cell survival	27
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	26
Human Atypical B Cells. An Overview	26
Neutrophils in aging and aging‐related pathologies	26
Metabolic Stress and Immune Activation in Heart Failure With a Preserved Ejection Fraction	26
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	26
Issue Information	25
Ontogenetic Diversification of Type 2 Conventional Dendritic Cells in the Bone Marrow: A Central Logic for Peripheral Immunity	25
Issue Information	25
	25
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	25
Swimming Through Dendritic Cell Biology: Insights From Fish Models	24
The impact of the human gut microbiome on the treatment of autoimmune disease	24
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	24
The nervous system during COVID‐19: Caught in the crossfire	24
ILC2 Diversity, Location, and Function in Pulmonary Disease	24
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	23
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	23
	23
Sex Differences in Metabolite–Immune Circuits of Neuroinflammation	23
Issue Information	23
The impact of neuroinflammation on neuronal integrity	23
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	23
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	23
	23
Dendritic Cell Heterogeneity Tailored to Their Function	22
Innate Immune Sensors in Health and Disease	22
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	22
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	22
Signals that control MAIT cell function in healthy and inflamed human tissues	22
Inflammation‐Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity	22
Established and emerging roles for mitochondria in neutrophils	22
Microbes and the fate of neutrophils	22
	21
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	21
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	21
Life‐threatening antibodies: The discovery of anaphylaxis	21
Thymic Dendritic Cells Revisited	21
Additional Cover	21
	21
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	20
Role of B cells in immune‐related adverse events following checkpoint blockade	20
Mechanosensing in Dendritic Cells	20
Dendritic Cells in the Gastrointestinal System: Division of Labor, Plasticity, and Niche‐Specific Adaptation	20
Copper homeostasis and cuproptosis in cancer immunity and therapy	19
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	19
Regulation of immune responses to food by commensal microbes	19
From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology	19
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	19
Introductory article for Immunological Reviews, Vol 310	18
Correction to “The Integrin Receptors: From Discovery to Structure to Medicines”	18
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases	18
Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan	18
Small matters: Introduction to extracellular vesicles	18
Trained Immunity and Cardiovascular Risk: An Immunological Perspective	18
B Cell Subsets and Atherosclerosis: Updates and Emerging Concepts	18
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer	18

Cover Image	18
CD4 T cells and toxicity from immune checkpoint blockade	18
The Immunology of Alpha‐Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat	18
The emergence of the calvarial hematopoietic niche in health and disease	17
	17
Physiology and pathology of the C3 amplification cycle: A retrospective	17
Antibodies against endogenous retroviruses	17
Issue Information	17
Epitope‐Specific Antibodies in Allergic Disease and Clinical Tolerance	17
Severe combined immunodeficiency diagnosis and genetic defects	17
Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19	17
How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection	17
My story of sex, gender, and women's health in a pandemic*	16
Inflammation and Immunogenetics in Cardiomyopathies: From Molecular Mechanisms to Therapeutic Perspectives	16
Whence and wherefore IgE?	16
Issue Information	16
Living in LALA land? Forty years of attenuating Fc effector functions	16
Molecular determinants of immunogenic cell death elicited by radiation therapy	16
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	16
The susceptibility of the kidney to alternative pathway activation—A hypothesis	16
Low‐density granulocytes in systemic autoimmunity and autoinflammation	16
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	16
Intersection of the microbiome and immune metabolism in lupus	16
A Brief Molecular History of Vγ9Vδ2 TCR ‐Mediated Phosphoantigen Sensing	16
Stress/cell death pathways, neuroinflammation, and neuropathic pain	16
Issue Information	16
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	16
Current knowledge on the early stages of human neutropoiesis	15
Age‐related macular degeneration: A disease of extracellular complement amplification	15
AIRE's Complex Role Beyond Promiscuous Gene Expression	15
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	15
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	15
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	15
The resolution of phagosomes	15
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	15
An Outside‐In View of the Beneficial and Detrimental Impact of Type‐2 Inflammation in the Lung	15
The Sunrise of Tertiary Lymphoid Structures in Cancer	15
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	15
	15
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	15
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	14
Engineered exosomes for studies in tumor immunology	14
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	14
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	14
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	14
Maternal IgE Influence on Fetal and Infant Health	14
Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	14
Unique aspects of IFN‐γ/STAT1 signaling in neurons	14
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	14
Coordinated Regulation of Extrafollicular B Cell Responses by IL ‐12 and IFN γ	14
Early life imprinting of intestinal immune tolerance and tissue homeostasis	13
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	13
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	13
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	13
	13
	13
IgE in Allergic Diseases	13
Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens	13
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	13
Apoptotic cell clearance components in inflammatory arthritis	13
C3‐dependent effector functions of complement	13
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	13
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	13
Functional neutrophil disorders: Chronic granulomatous disease and beyond	13
Sex Differences in the Impact of Obesity on Immunity	13
Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies	12
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	12
The Factor H protein family: The switchers of the complement alternative pathway	12
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	12
The complement alternative pathway in health and disease—activation or amplification?	12
Gene therapy for adenosine deaminase severe combined immune deficiency—An unexpected journey of four decades	12
Sex as a Biological Variable in Tuberculosis Pathogenesis	12
Maternal‐driven immune education in offspring	12
Sex Differences in Alloimmunity and Other Immunological Considerations in Organ Transplantation	12
The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch	12
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation	12
The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets	12
Decoding immunogenic cell death from a dendritic cell perspective	11
A newborn's perspective on immune responses to food	11
	11
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	11
Mixed Signals: T Cells as Architects of IgE Immunity	11
	11
Pyroptosis in glioma: Current management and future application	11
Type I interferon and cancer	11
Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity	11
Transcriptional and hormonal control of adipose Treg heterogeneity and function	10
Microbes mediated immunogenic cell death in cancer immunotherapy	10
The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms	10
Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism	10
Issue Information	10
Thymic Mimetic Cells: Evolutionarily Ancient Mirrors of the Periphery	10
Primary and secondary defects of the thymus	10
Intracellular complement: Evidence, definitions, controversies, and solutions	10
Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies	10