Immunological Reviews

Article	Citations
Issue Information	270
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	235
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	134
Imaging dendritic cell functions*	96
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	88
Cover Image	85
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	83
Superoxide: The enigmatic chemical chameleon in neutrophil biology	79
Immune checkpoint inhibitors in infectious disease	78
Role of inflammasomes and neuroinflammation in epilepsy	74
Metabolic regulation of type I interferon production	72
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	67
NETosis: Sculpting tumor metastasis and immunotherapy	66
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	65
Issue Information	63
Antigen‐specific and cross‐reactive T cells in protection and disease	63
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	61
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	61
Layered origins of lymphoid tissue inducer cells	59
The immune system in Down Syndrome: Autoimmunity and severe infections	57
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	55
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	55
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	55
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	51
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	48

The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	48
With complements: C3 inhibition in the clinic	44
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	44
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	44
Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	43
Cover Image	42
Functional Insights From Immunoreceptor Structures	42
Maternal influences on offspring food allergy	41
Autoimmunity and the microbiome	41
An introduction to neuroimmunology	40
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Issue Information	38
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	38
Issue Information	38
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	38
Common variable immunodeficiency, cross currents, and prevailing winds	38
Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases*	37
ZAP70, too little, too much can lead to autoimmunity*	37
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	36
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	36
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	36
Issue Information	36
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Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	36
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	35
Axes of heterogeneity in human tissue‐resident memory T cells	35
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	34
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	34
Glycobiology of IgE	34
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	34
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	34
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	33
Modulation of immunity by the secreted phospholipase A2 family	33
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	32
Human neutrophils ≠ murine neutrophils: Does it matter?	32
PANoptosis: Mechanisms, biology, and role in disease	31
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Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	30
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	29
Structural Immunology of SARS‐CoV‐2	29
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	29
Factor D	29
From Lymphotoxin to Tertiary Lymphoid Structures and Beyond	29
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	29
Cover Image	29
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	29
Irritable bowel syndrome: When food is a pain in the gut	29
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	28
Host immune responses in the central nervous system during fungal infections	28
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Development and organization of omental milky spots	27
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	27
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	27
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	27
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	27
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	26
Many Achilles’ heels of B and T cell tolerance	26
Issue Information	26
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	25
Cover Image	25
No time to die: Epigenetic regulation of natural killer cell survival	25
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	25
Cover Image	25
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	24
Human Atypical B Cells. An Overview	24
Transcriptional and epigenetic regulation in thymic epithelial cells*	24
Low‐molecular weight inhibitors of the alternative complement pathway	24
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	23
Stability and change in epigenetic regulation of immune cells	23
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	22
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	22
Innate Immunity and Asthma Exacerbations: Insights From Human Models	22
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	22
Neutrophils in aging and aging‐related pathologies	22
Issue Information	21
ILC2 Diversity, Location, and Function in Pulmonary Disease	20
The nervous system during COVID‐19: Caught in the crossfire	20
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	20
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The impact of the human gut microbiome on the treatment of autoimmune disease	20
Visualization and functional characterization of lymphoid organ fibroblasts*	20
Issue Information	20
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	19
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The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	19
The impact of neuroinflammation on neuronal integrity	19
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	19
Imaging leukocyte migration through afferent lymphatics*	18
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	18
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	18
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	18
Innate Immune Sensors in Health and Disease	18
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	18
Signals that control MAIT cell function in healthy and inflamed human tissues	17
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	17
Established and emerging roles for mitochondria in neutrophils	17
Issue Information	17
Microbes and the fate of neutrophils	17
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	17
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Regulation of immune responses to food by commensal microbes	16
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	16
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Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	16
Additional Cover	16
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	16
Life‐threatening antibodies: The discovery of anaphylaxis	16
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	16
Role of B cells in immune‐related adverse events following checkpoint blockade	16
What sequencing technologies can teach us about innate immunity*	15
Imaging the immune system redux	15
Small matters: Introduction to extracellular vesicles	15
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	15
Introductory article for Immunological Reviews, Vol 310	15
Copper homeostasis and cuproptosis in cancer immunity and therapy	15
Severe combined immunodeficiency diagnosis and genetic defects	14
Cover Image	14
CD4 T cells and toxicity from immune checkpoint blockade	14
Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis	14
The role of dysregulated PI3Kdelta signaling in human autoimmunity*	14
Issue Information	13
Antibodies against endogenous retroviruses	13
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*	13
Molecular determinants of immunogenic cell death elicited by radiation therapy	13
The susceptibility of the kidney to alternative pathway activation—A hypothesis	13
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer	13
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*	13
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases	13
My story of sex, gender, and women's health in a pandemic*	13

A Brief Molecular History of Vγ9Vδ2 TCR‐Mediated Phosphoantigen Sensing	13
The Immunology of Alpha‐Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat	13
The emergence of the calvarial hematopoietic niche in health and disease	13
Spatial determinates of effector and memory CD8+ T cell fates*	13
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Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19	12
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	12
Physiology and pathology of the C3 amplification cycle: A retrospective	12
Issue Information	12
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	12
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	12
Age‐related macular degeneration: A disease of extracellular complement amplification	12
Living in LALA land? Forty years of attenuating Fc effector functions	12
Epitope‐Specific Antibodies in Allergic Disease and Clinical Tolerance	12
Intersection of the microbiome and immune metabolism in lupus	12
Whence and wherefore IgE?	12
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	12
Current knowledge on the early stages of human neutropoiesis	12
The Sunrise of Tertiary Lymphoid Structures in Cancer	12
Low‐density granulocytes in systemic autoimmunity and autoinflammation	12
Stress/cell death pathways, neuroinflammation, and neuropathic pain	12
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Issue Information	12
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	12
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	12
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	12
Maternal IgE Influence on Fetal and Infant Health	11
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	11
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An Outside‐In View of the Beneficial and Detrimental Impact of Type‐2 Inflammation in the Lung	11
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	11
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	11
Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	11
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	11
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	11
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	11
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	11
Early life imprinting of intestinal immune tolerance and tissue homeostasis	11
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Engineered exosomes for studies in tumor immunology	11
The resolution of phagosomes	11
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	11
Epigenetics and CD8+ T cell memory*	11
Coordinated Regulation of Extrafollicular B Cell Responses by IL‐12 and IFNγ	11
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	11
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	10
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	10
C3‐dependent effector functions of complement	10
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	10
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	10
The complement alternative pathway in health and disease—activation or amplification?	10
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	10
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	10
Heterogeneity in antiviral B cell responses: Lessons from the movies*	10
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	10
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IgE in Allergic Diseases	10
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Unique aspects of IFN‐γ/STAT1 signaling in neurons	10
Apoptotic cell clearance components in inflammatory arthritis	10
Functional neutrophil disorders: Chronic granulomatous disease and beyond	10
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	10
Maternal‐driven immune education in offspring	10
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation	9
Gene therapy for adenosine deaminase severe combined immune deficiency—An unexpected journey of four decades	9
Decoding immunogenic cell death from a dendritic cell perspective	9
Type I interferon and cancer	9
Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism	9
Issue Information	9
The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets	9
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	9
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	9
The Factor H protein family: The switchers of the complement alternative pathway	9
The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch	9
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Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies	9
Information flow in the spatiotemporal organization of immune responses*	9
Pyroptosis in glioma: Current management and future application	9
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	9
Issue Information	9
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A newborn's perspective on immune responses to food	8
Epigenetic control of microglial immune responses	8
Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies	8
Multiple waves of fetal‐derived immune cells constitute adult immune system	8
Mechanisms for initiation of food allergy by skin pre‐disposed to atopic dermatitis	8
Thymic Mimetic Cells: Evolutionarily Ancient Mirrors of the Periphery	8
Using immunogenic cell death to improve anticancer efficacy of immune checkpoint inhibitors: From basic science to clinical application	8
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The layered development of mouse B and T Cells	8
The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms	8
Issue Information	8
Tissue‐resident memory T cells and lung immunopathology	8
Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity	8
Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis	8