Immunological Reviews

Article	Citations
Issue Information	248
Issue Information	220
Immune checkpoint inhibitors in infectious disease	168
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	130
Superoxide: The enigmatic chemical chameleon in neutrophil biology	117
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	87
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	76
Cover Image	72
Imaging dendritic cell functions*	66
NETosis: Sculpting tumor metastasis and immunotherapy	66
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	62
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	60
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	54
Metabolic regulation of type I interferon production	54
Antigen‐specific and cross‐reactive T cells in protection and disease	53
Role of inflammasomes and neuroinflammation in epilepsy	51
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	50
Issue Information	48
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	47
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	47
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	47
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	47
Layered origins of lymphoid tissue inducer cells	47
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	47
With complements: C3 inhibition in the clinic	46

The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	46
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	44
Fibroblasts and macrophages: Collaborators in tissue homeostasis	42
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	41
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	40
The immune system in Down Syndrome: Autoimmunity and severe infections	40
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An introduction to neuroimmunology	39
ZAP70, too little, too much can lead to autoimmunity*	39
Common variable immunodeficiency, cross currents, and prevailing winds	38
Cover Image	38
Sequence determinants as key regulators in gene expression of T cells	36
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	36
Autoimmunity and the microbiome	35
Maternal influences on offspring food allergy	34
Issue Information	34
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Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases*	33
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	33
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	33
Issue Information	33
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	33
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	33
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	32
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	32
Issue Information	32
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	31
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	31
Axes of heterogeneity in human tissue‐resident memory T cells	31
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	30
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	30
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	30
Glycobiology of IgE	30
Modulation of immunity by the secreted phospholipase A2 family	28
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	28
Human neutrophils ≠ murine neutrophils: Does it matter?	28
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PANoptosis: Mechanisms, biology, and role in disease	27
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	27
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	26
Structural Immunology of SARS‐CoV‐2	26
Cover Image	26
Factor D	26
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	25
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	25
Perivascular stromal cells: Directors of tissue immune niches	25
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	25
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	25
Development and organization of omental milky spots	24
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Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	24
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	24
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	24
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	24
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	23
Stability and change in epigenetic regulation of immune cells	23
Host immune responses in the central nervous system during fungal infections	23
Issue Information	23
Irritable bowel syndrome: When food is a pain in the gut	23
Many Achilles’ heels of B and T cell tolerance	23
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	22
The fibroblast: An emerging key player in thymic T cell selection	22
Innate Immunity and Asthma Exacerbations: Insights From Human Models	22
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	22
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	22
Cover Image	22
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	21
No time to die: Epigenetic regulation of natural killer cell survival	21
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	21
Cover Image	21
Transcriptional and epigenetic regulation in thymic epithelial cells*	21
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	20
Neutrophils in aging and aging‐related pathologies	20
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	20
Issue Information	20
Low‐molecular weight inhibitors of the alternative complement pathway	20
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The gene regulatory network controlling plasma cell function	19
The impact of the human gut microbiome on the treatment of autoimmune disease	19
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	19
The nervous system during COVID‐19: Caught in the crossfire	19
Visualization and functional characterization of lymphoid organ fibroblasts*	19
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The impact of neuroinflammation on neuronal integrity	18
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Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	18
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	18
Signals that control MAIT cell function in healthy and inflamed human tissues	18
Regnase‐1–related endoribonucleases in health and immunological diseases	18
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	18
Innate Immune Sensors in Health and Disease	18
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	17
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	17
Established and emerging roles for mitochondria in neutrophils	17
Imaging leukocyte migration through afferent lymphatics*	17
Microbes and the fate of neutrophils	17
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	17
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	16
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	16
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G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	16
Issue Information	16
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	15
Copper homeostasis and cuproptosis in cancer immunity and therapy	15
Immunoregulation by antibody secreting cells in inflammation, infection, and cancer	15
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Role of B cells in immune‐related adverse events following checkpoint blockade	15
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	15
Introductory article for Immunological Reviews, Vol 310	15
Regulation of immune responses to food by commensal microbes	15
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	15
Imaging the immune system redux	15
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	15
Small matters: Introduction to extracellular vesicles	15
Life‐threatening antibodies: The discovery of anaphylaxis	15
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	15
What sequencing technologies can teach us about innate immunity*	14
The role of dysregulated PI3Kdelta signaling in human autoimmunity*	14
Antibodies against endogenous retroviruses	14
CD4 T cells and toxicity from immune checkpoint blockade	14
Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses*	14
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer	14
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases	14
Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis	13
The emergence of the calvarial hematopoietic niche in health and disease	13
Issue Information	13
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*	13
Severe combined immunodeficiency diagnosis and genetic defects	13
Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19	12

Intersection of the microbiome and immune metabolism in lupus	12
My story of sex, gender, and women's health in a pandemic*	12
A Brief Molecular History of Vγ9Vδ2 TCR‐Mediated Phosphoantigen Sensing	12
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	12
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Spatial determinates of effector and memory CD8+ T cell fates*	12
The susceptibility of the kidney to alternative pathway activation—A hypothesis	12
Whence and wherefore IgE?	12
Low‐density granulocytes in systemic autoimmunity and autoinflammation	12
Physiology and pathology of the C3 amplification cycle: A retrospective	12
Molecular determinants of immunogenic cell death elicited by radiation therapy	12
Living in LALA land? Forty years of attenuating Fc effector functions	12
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	11
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	11
Epigenetics and CD8+ T cell memory*	11
Issue Information	11
Issue Information	11
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	11
Current knowledge on the early stages of human neutropoiesis	11
Stress/cell death pathways, neuroinflammation, and neuropathic pain	11
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	11
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	11
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	11
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	10
The resolution of phagosomes	10
Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	10
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	10
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At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	10
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	10
Age‐related macular degeneration: A disease of extracellular complement amplification	10
C3‐dependent effector functions of complement	10
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	10
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	10
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	10
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Neutrophil‐T cell crosstalk and the control of the host inflammatory response	10
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	10
Apoptotic cell clearance components in inflammatory arthritis	9
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	9
Early life imprinting of intestinal immune tolerance and tissue homeostasis	9
How RNA modifications regulate the antiviral response	9
Coordinated Regulation of Extrafollicular B Cell Responses by IL‐12 and IFNγ	9
Regulation of airway immunity by epithelial miRNAs	9
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	9
Functional neutrophil disorders: Chronic granulomatous disease and beyond	9
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	9
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	9
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	9
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	9
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	9
Heterogeneity in antiviral B cell responses: Lessons from the movies*	9
Engineered exosomes for studies in tumor immunology	9
Unique aspects of IFN‐γ/STAT1 signaling in neurons	9
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	9
Maternal IgE Influence on Fetal and Infant Health	9
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The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch	8
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation	8
Maternal‐driven immune education in offspring	8
The special unfolded protein response in plasma cells	8
The Factor H protein family: The switchers of the complement alternative pathway	8
Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism	8
Information flow in the spatiotemporal organization of immune responses*	8
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	8
The complement alternative pathway in health and disease—activation or amplification?	8
The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets	8
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	8
Decoding immunogenic cell death from a dendritic cell perspective	8
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	8
Gene therapy for adenosine deaminase severe combined immune deficiency—An unexpected journey of four decades	8
Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies	8
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Issue Information	8
Type I interferon and cancer	8
Pyroptosis in glioma: Current management and future application	8
A newborn's perspective on immune responses to food	7
Issue Information	7
Epigenetic regulation of natural killer cell memory*	7
Small particles with large impact: Insights into the unresolved roles of innate immunity in extracellular vesicle‐mediated cardiovascular calcification	7
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Transcriptional and hormonal control of adipose Treg heterogeneity and function	7
Targeting ferroptosis in gastric cancer: Strategies and opportunities	7
Intracellular complement: Evidence, definitions, controversies, and solutions	7
Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies	7
The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms	7
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Primary and secondary defects of the thymus	7
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Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment	7
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Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity	6
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The neutrophil: A key resourceful agent in immune‐mediated vasculitis	6