Immunological Reviews

Article	Citations
Issue Information	285
Cover Image	149
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	142
In Defense of Homeostasis: Innate Immunity in Cardiac Injury and Repair	138
Metabolic regulation of type I interferon production	136
Reframing Thymic Biology: From AIRE to Mimetics, Thymflammation, Regeneration, and Beyond	135
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	122
Superoxide: The enigmatic chemical chameleon in neutrophil biology	122
The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ	121
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	103
Bridging pDCs and cDCs : The Identity of Transitional Dendritic Cells	100
NETosis: Sculpting tumor metastasis and immunotherapy	98
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	91
Role of inflammasomes and neuroinflammation in epilepsy	88
Antigen‐specific and cross‐reactive T cells in protection and disease	85
Immune checkpoint inhibitors in infectious disease	84
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	82
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	79
Issue Information	78
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	71
Layered origins of lymphoid tissue inducer cells	69
Mechanisms Promoting Stability of B Cells	65
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	64
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	64
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	62

Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	61
With complements: C3 inhibition in the clinic	61
The immune system in Down Syndrome: Autoimmunity and severe infections	61
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	59
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	59
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	58
Cover Image	56
Issue Information	56
Functional Insights From Immunoreceptor Structures	55
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	53
An introduction to neuroimmunology	52
Sex Differences in Lung Immunity	52
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Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	51
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Issue Information	51
Artery Tertiary Lymphoid Organs Form Neuroimmune Cardiovascular Interfaces in Atherosclerosis	50
Sex Differences in Asthma Pathogenesis	50
Autoimmunity and the microbiome	50
Common variable immunodeficiency, cross currents, and prevailing winds	50
Immune Mechanisms of Viral, Autoimmune, and Immune Checkpoint Inhibitor‐Associated Myocarditis	49
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	49
Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	49
Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes	48
Maternal influences on offspring food allergy	48
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	48
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	47
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	47
Axes of heterogeneity in human tissue‐resident memory T cells	46
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	45
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	45
Glycobiology of IgE	42
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	42
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	41
Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity	41
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	40
PANoptosis: Mechanisms, biology, and role in disease	40
GC B Cells, Tfh Cells, and Influenza bnAbs : Insights for Improving Universal Vaccine Design	38
Targeting Inflammation in Atherosclerotic Cardiovascular Disease: Mechanisms and Emerging Therapies	38
Human neutrophils ≠ murine neutrophils: Does it matter?	38
Modulation of immunity by the secreted phospholipase A2 family	38
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Cover Image	37
Factor D	36
Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis	36
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	35
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	35
Structural Immunology of SARS‐CoV‐2	35
Anti‐Modified Protein Antibodies in Rheumatoid Arthritis: Pathogenic, Protective, or Passive Bystander?	35

From Lymphotoxin to Tertiary Lymphoid Structures and Beyond	33
Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures	32
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	32
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Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	31
Development and organization of omental milky spots	31
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	31
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	31
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	31
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	31
The X Factor in Immunity: Sex Differences Shaped by the X Chromosome	30
Irritable bowel syndrome: When food is a pain in the gut	30
Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design	30
Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies	30
Cover Image	29
Biology of IgE	29
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	29
Cover Image	29
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	28
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	28
Type 2 IgG Memory B Cells and Long‐Lived IgE Plasma Cells in the Persistence of Allergy	28
Metabolic Stress and Immune Activation in Heart Failure With a Preserved Ejection Fraction	28
Innate Immunity and Asthma Exacerbations: Insights From Human Models	28
Low‐molecular weight inhibitors of the alternative complement pathway	28
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	27
No time to die: Epigenetic regulation of natural killer cell survival	27
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	27
Neutrophils in aging and aging‐related pathologies	27
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	27
Issue Information	26
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The impact of the human gut microbiome on the treatment of autoimmune disease	26
Human Atypical B Cells. An Overview	26
The impact of neuroinflammation on neuronal integrity	26
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	26
Issue Information	26
Swimming Through Dendritic Cell Biology: Insights From Fish Models	26
Myocardial Immune Niches in Homeostasis and Inflammation	25
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Ontogenetic Diversification of Type 2 Conventional Dendritic Cells in the Bone Marrow: A Central Logic for Peripheral Immunity	25
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ILC2 Diversity, Location, and Function in Pulmonary Disease	25
Dendritic Cell Heterogeneity Tailored to Their Function	24
Signals that control MAIT cell function in healthy and inflamed human tissues	24
Inflammation‐Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity	24
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	24
Microbes and the fate of neutrophils	24
Issue Information	24
Sex Differences in Metabolite–Immune Circuits of Neuroinflammation	24
Innate Immune Sensors in Health and Disease	24
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	23
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	23
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	23
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	22
Thymic Dendritic Cells Revisited	22
Additional Cover	21
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	21
Established and emerging roles for mitochondria in neutrophils	21
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Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	21
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	21
Life‐threatening antibodies: The discovery of anaphylaxis	21
From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology	20
Dendritic Cells in the Gastrointestinal System: Division of Labor, Plasticity, and Niche‐Specific Adaptation	20
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	20
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	20
Role of B cells in immune‐related adverse events following checkpoint blockade	20
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	20
Copper homeostasis and cuproptosis in cancer immunity and therapy	20
Mechanosensing in Dendritic Cells	20
Regulation of immune responses to food by commensal microbes	20
Introductory article for Immunological Reviews, Vol 310	20
Cover Image	19
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer	19
Trained Immunity and Cardiovascular Risk: An Immunological Perspective	19
Correction to “The Integrin Receptors: From Discovery to Structure to Medicines”	19
B Cell Subsets and Atherosclerosis: Updates and Emerging Concepts	19
The Immunology of Alpha‐Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat	19
Small matters: Introduction to extracellular vesicles	19
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases	19

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan	19
Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19	18
CD4 T cells and toxicity from immune checkpoint blockade	18
Epitope‐Specific Antibodies in Allergic Disease and Clinical Tolerance	18
A Brief Molecular History of Vγ9Vδ2 TCR ‐Mediated Phosphoantigen Sensing	18
How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection	18
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Physiology and pathology of the C3 amplification cycle: A retrospective	18
Severe combined immunodeficiency diagnosis and genetic defects	18
Whence and wherefore IgE?	18
Inflammation and Immunogenetics in Cardiomyopathies: From Molecular Mechanisms to Therapeutic Perspectives	18
Issue Information	18
Antibodies against endogenous retroviruses	18
The susceptibility of the kidney to alternative pathway activation—A hypothesis	18
Low‐density granulocytes in systemic autoimmunity and autoinflammation	18
Issue Information	17
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	17
Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation	17
Issue Information	17
The resolution of phagosomes	17
Stress/cell death pathways, neuroinflammation, and neuropathic pain	17
Intersection of the microbiome and immune metabolism in lupus	17
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	17
Current knowledge on the early stages of human neutropoiesis	17
Molecular determinants of immunogenic cell death elicited by radiation therapy	17
Living in LALA land? Forty years of attenuating Fc effector functions	17
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	16
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	16
Age‐related macular degeneration: A disease of extracellular complement amplification	16
AIRE's Complex Role Beyond Promiscuous Gene Expression	16
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	16
The Sunrise of Tertiary Lymphoid Structures in Cancer	16
Maternal IgE Influence on Fetal and Infant Health	16
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	16
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	16
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	16
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	16
C3‐dependent effector functions of complement	15
Early life imprinting of intestinal immune tolerance and tissue homeostasis	15
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	15
Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	15
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	15
Coordinated Regulation of Extrafollicular B Cell Responses by IL ‐12 and IFN γ	15
An Outside‐In View of the Beneficial and Detrimental Impact of Type‐2 Inflammation in the Lung	15
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	15
Neutrophil‐T cell crosstalk and the control of the host inflammatory response	15
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Apoptotic cell clearance components in inflammatory arthritis	14
Functional neutrophil disorders: Chronic granulomatous disease and beyond	14
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	14
IgE in Allergic Diseases	14
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	14
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	14
Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens	14
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	14
Sex Differences in the Impact of Obesity on Immunity	13
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation	13
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Sex as a Biological Variable in Tuberculosis Pathogenesis	13
Gene therapy for adenosine deaminase severe combined immune deficiency—An unexpected journey of four decades	13
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	13
Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies	13
Sex Differences in Alloimmunity and Other Immunological Considerations in Organ Transplantation	13
Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract	12
The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch	12
Mixed Signals: T Cells as Architects of IgE Immunity	12
Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways	12
The complement alternative pathway in health and disease—activation or amplification?	12
The Factor H protein family: The switchers of the complement alternative pathway	12
Type I interferon and cancer	12
Decoding immunogenic cell death from a dendritic cell perspective	12
Pyroptosis in glioma: Current management and future application	12
The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets	12
Maternal‐driven immune education in offspring	12
Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response	12
Sex‐Specific Factors Influencing HIV Infection	11
Issue Information	11
Targeting ferroptosis in gastric cancer: Strategies and opportunities	11
Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism	11
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Small particles with large impact: Insights into the unresolved roles of innate immunity in extracellular vesicle‐mediated cardiovascular calcification	11
Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity	11
A newborn's perspective on immune responses to food	11
Transcriptional and hormonal control of adipose Treg heterogeneity and function	11
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The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms	11
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Intracellular complement: Evidence, definitions, controversies, and solutions	11
Primary and secondary defects of the thymus	11
Introduction: Sex as a Biological Variable in Immunity	10
Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity	10
Microbes mediated immunogenic cell death in cancer immunotherapy	10
Mechanisms for initiation of food allergy by skin pre‐disposed to atopic dermatitis	10
Thymic Mimetic Cells: Evolutionarily Ancient Mirrors of the Periphery	10