Immunological Reviews

Article	Citations
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	235
Low‐molecular weight inhibitors of the alternative complement pathway	209
Issue Information	156
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Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	111
Epigenetics and CD8+ T cell memory*	79
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	79
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	73
The right educational environment: Oral tolerance in early life	69
Issue Information	63
Sensory sentinels: Neuroimmune detection and food allergy	62
Insights into the clinical, immunologic, and genetic underpinnings of food allergy	60
Pathogenic mechanisms in the evolution of food allergy	53
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Issue Information	48
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	47
Many Achilles’ heels of B and T cell tolerance	47
RNA regulatory mechanisms that control antiviral innate immunity	46
The resolution of phagosomes	45
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Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation	45

No time to die: Epigenetic regulation of natural killer cell survival	45
Memories that last: Dynamics of memory T cells throughout the body	44
Issue Information	43
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	42
Stability and change in epigenetic regulation of immune cells	42
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	41
Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy	39
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	38
Functional genomics in inborn errors of immunity	38
The potency of hematopoietic stem cell reprogramming for changing immune tone	38
Transcriptional and epigenetic regulation in thymic epithelial cells*	37
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	36
Issue Information	35
The Effector Functions of Antibodies	35
Immunoglobulin A Antibodies: From Protection to Harmful Roles	33
The function of antibodies	32
Immune checkpoint inhibitors in infectious disease	32
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	32
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Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition	31
Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*	31
The neutrophil: A key resourceful agent in immune‐mediated vasculitis	31
Rheumatic complications of checkpoint inhibitors: Lessons from autoimmunity	30
Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases	30
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	30
Antigen‐specific and cross‐reactive T cells in protection and disease	30
Imaging the different timescales of germinal center selection*	30
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Issue Information	29
Nucleic acid sensing in the central nervous system: Implications for neural circuit development, function, and degeneration	29
The fibroblast: An emerging key player in thymic T cell selection	28
A variety of death modes of neutrophils and their role in the etiology of autoimmune diseases	28
Imaging dendritic cell functions*	28
Age‐related macular degeneration: A disease of extracellular complement amplification	27
Role of inhibitory signaling in peripheral B cell tolerance*	27
Superoxide: The enigmatic chemical chameleon in neutrophil biology	26
B cells going viral in theCNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis	26
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	26
Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells	26
Next‐generation chimeric antigen receptors for T‐ and natural killer‐cell therapies against cancer	24
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	24
N1 versus N2 and PMN‐MDSC: A critical appraisal of current concepts on tumor‐associated neutrophils and new directions for human oncology	24
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	24
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	24
The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunity	23
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	23
Regulation of the NLRP3 inflammasome by autophagy and mitophagy	23
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	23
Current knowledge on the early stages of human neutropoiesis	23
Innate Immunity and Asthma Exacerbations: Insights From Human Models	23

Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	22
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	22
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	22
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	22
Signaling Activation and Modulation in Extrafollicular B Cell Responses	22
Role of inflammasomes and neuroinflammation in epilepsy	22
A Structural Voyage Toward the Landscape of Humoral and Cellular Immune Escapes of SARS‐CoV‐2	22
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	21
Metabolic regulation of type I interferon production	21
Neutrophils in aging and aging‐related pathologies	21
NETosis: Sculpting tumor metastasis and immunotherapy	21
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	20
The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids	20
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The gene regulatory network controlling plasma cell function	19
Insights into phenotypic and functional CD8+ TRM heterogeneity	19
Toward the clinical development of synthetic immunity to cancer	19
The cell stress and immunity cycle in cancer: Toward next generation of cancer immunotherapy	19
Routine SARS‐CoV‐2 vaccination for all children*	19
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	18
Plasma cell biology: Foundations for targeted therapeutic development in transplantation	18
Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney	18
Issue Information	17
Stem‐like T cells in cancer and autoimmunity	17
T cells in obesity‐associated inflammation: The devil is in the details	17
The impact of the human gut microbiome on the treatment of autoimmune disease	17
The influence of aging and the microbiome in multiple sclerosis and other neurologic diseases	17
Antibodies in breast milk: Pro‐bodies designed for healthy newborn development	16
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Stromal cells in tertiary lymphoid structures: Architects of autoimmunity	16
Regulatory strategies limiting endosomal Toll‐like receptor activation in B cells*	16
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	16
Surfing on the waves of the human γδ T cell ontogenic sea	16
Unique aspects of IFN‐γ/STAT1 signaling in neurons	16
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Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	15
The Evolving T Cell Receptor Recognition Code: The Rules Are More Like Guidelines	15
Transcriptomics for child and adolescent tuberculosis*	15
How RNA modifications regulate the antiviral response	15
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	15
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	15
The immune system in Down Syndrome: Autoimmunity and severe infections	15
With complements: C3 inhibition in the clinic	15
Inside the phagosome: A bacterial perspective	15
Issue Information	15
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Modulation of plasmacytoid dendritic cells response in inflammation and autoimmunity	15
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	15
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	15
Lipid metabolism in dendritic cell biology	15
Issue Information	15
Extrinsic and intrinsic drivers of natural killer cell clonality	14
Macrophage‐fibroblast circuits in the spleen	14
Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research	14
Epigenetic gene regulation in plasma cells	14
T‐cell heterogeneity, progenitor–progeny relationships, and function during latent and chronic viral infections	14
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	14
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	14
The complement alternative pathway and hemostasis	14
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	14
Stellabody: A novel hexamer‐promoting mutation for improved IgG potency	13
The nervous system during COVID‐19: Caught in the crossfire	13
Engineered exosomes for studies in tumor immunology	13
How Technical Advances Changed the Concept of Antibodies	13
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Neutrophil‐T cell crosstalk and the control of the host inflammatory response	13
Fibroblasts and macrophages: Collaborators in tissue homeostasis	13
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Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	13
Visualization and functional characterization of lymphoid organ fibroblasts*	12
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Regnase‐1–related endoribonucleases in health and immunological diseases	12
Understanding very early onset inflammatory bowel disease (VEOIBD) in relation to inborn errors of immunity	12
Circulating tissue factor‐positive extracellular vesicles and their association with thrombosis in different diseases	12
ITAM‐based receptors in natural killer cells	12
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Z‐Nucleic Acid Sensing and Activation of ZBP1 in Cellular Physiology and Disease Pathogenesis	11

Early‐Life Host–Microbial Interactions and Asthma Development: A Lifelong Impact?	11
Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*	11
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	11
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	11
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	11
The impact of neuroinflammation on neuronal integrity	11
Innate Immunity Never “NODs” Off: NLRs Regulate the Host Anti‐Viral Immune Response	11
Layered origins of lymphoid tissue inducer cells	11
The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation	10
Neuroinflammation: Extinguishing a blaze of T cells	10
C3‐dependent effector functions of complement	10
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Early life imprinting of intestinal immune tolerance and tissue homeostasis	10
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	10
Inborn errors of immunity illuminate mechanisms of human immunology and pave the road to precision medicine	10
Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease	10
Neutrophils as immune effector cells in antibody therapy in cancer	10
Interferons and epigenetic mechanisms in training, priming and tolerance of monocytes and hematopoietic progenitors	10
Issue Information	10
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	9
Nanobody‐based heavy chain antibodies and chimeric antibodies	9
Current insights into apolipoprotein E and the immune response in Alzheimer's disease	9
B cell/stromal cell crosstalk in health, disease, and treatment: Follicular lymphoma as a paradigm	9
An introduction to neuroimmunology	9
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Fc Effector Function of Immune Checkpoint Blocking Antibodies in Oncology	9
Autoimmunity and the microbiome	9
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Pathogenic role of anti‐nuclear autoantibodies in systemic sclerosis: Insights from other rheumatic diseases	9
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Immunological mechanisms underlying clinical phenotypes and noninvasive diagnosis of immune checkpoint inhibitor‐induced kidney disease	8
Regulation of airway immunity by epithelial miRNAs	8
Skin‐ny deeping: Uncovering immune cell behavior and function through imaging techniques*	8
Exploring epigenetic reprogramming during central nervous system infection	8
Issue Information	8
Harnessing the power of artificial intelligence to advance cell therapy	8
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The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	8
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	8
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Recognition of Self and Viral Ligands by NK Cell Receptors	8
Signals that control MAIT cell function in healthy and inflamed human tissues	8
T cell activation niches—Optimizing T cell effector function in inflamed and infected tissues*	8
Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets	8
A bird’s eye view of fibroblast heterogeneity: A pan‐disease, pan‐cancer perspective	8
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop	8
Microbial influences on severity and sex bias of systemic autoimmunity	7
ZAP70, too little, too much can lead to autoimmunity*	7
Applications of CRISPR technology in cellular immunotherapy	7
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	7
Engineering the IL‐4/IL‐13 axis for targeted immune modulation	7
The coming of age of neutrophil extracellular traps in thrombosis: Where are we now and where are we headed?	7
FOXP3 deficiency, from the mechanisms of the disease to curative strategies	7
Maternal influences on offspring food allergy	7
Alternative pathway diagnostics	7
Biophysical and Structural Features of αβT‐Cell Receptor Mechanosensing: A Paradigmatic Shift in Understanding T‐Cell Activation	7
The expanding family of neutrophil‐derived extracellular vesicles	7
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Sequence determinants as key regulators in gene expression of T cells	7
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Alternative pathway amplification and infections	7
Common variable immunodeficiency, cross currents, and prevailing winds	7
Fibroblast pathology in inflammatory joint disease	6
Established and emerging roles for mitochondria in neutrophils	6
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection*	6
Imaging leukocyte migration through afferent lymphatics*	6
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	6
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	6
Functional neutrophil disorders: Chronic granulomatous disease and beyond	6
Microbes and the fate of neutrophils	6
Apoptotic cell clearance components in inflammatory arthritis	6
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	6
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut	6
Immunity in adipose tissues: Cutting through the fat	6
Neutrophils during SARS‐CoV‐2 infection: Friend or foe?	6
The journey toward disease modification in cow milk protein allergy	6
Immunomodulatory and anti‐inflammatory properties of immunoglobulin G antibodies	6
Memory CD8+ T cell‐mediated protection against liver‐stage malaria	5
Heterogeneity in antiviral B cell responses: Lessons from the movies*	5
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	5
Innate Immune Sensors in Health and Disease	5
Mast cell ontogeny: From fetal development to life‐long health and disease	5
Initiation of the alternative pathway of complement and the history of “tickover”	5
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	5
Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma	5
CNS macrophage contributions to myelin health	5
The inflammatory speech of fibroblasts	5
Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities”	5
Memory B cells and plasma cells: The differentiative continuum of humoral immunity	5
The formation and function of the neutrophil phagosome	5