OOIR: Observatory of International Research

Papers

(The TQCC of Immunological Reviews is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Issue Information	287
Antigen‐specific and cross‐reactive T cells in protection and disease	242
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	171
Immune checkpoint inhibitors in infectious disease	108
Bridging pDCs and cDCs : The Identity of Transitional Dendritic Cells	107
Cover Image	107
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	103
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	98
NETosis: Sculpting tumor metastasis and immunotherapy	93
Metabolic regulation of type I interferon production	87
Superoxide: The enigmatic chemical chameleon in neutrophil biology	85
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	83
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	81
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	79
Role of inflammasomes and neuroinflammation in epilepsy	76
Issue Information	73
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	72
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	71
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	69
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	68
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	62
Mechanisms Promoting Stability of B Cells	60
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	58
Layered origins of lymphoid tissue inducer cells	57
With complements: C3 inhibition in the clinic	57

The immune system in Down Syndrome: Autoimmunity and severe infections	55
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	51
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	51
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	51
Autoimmunity and the microbiome	50
Maternal influences on offspring food allergy	49
Cover Image	48
Issue Information	47
Functional Insights From Immunoreceptor Structures	47
Common variable immunodeficiency, cross currents, and prevailing winds	46
	45
An introduction to neuroimmunology	45
	45
Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes	44
Issue Information	44
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	43
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	42
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	42
Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	42
Activation pathways that drive CD4⁺ T cells to break tolerance in autoimmune diseases*	42
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	41
Issue Information	41
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	39
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	39
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	39
Glycobiology of IgE	38
Human neutrophils ≠ murine neutrophils: Does it matter?	38
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	38
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	37
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	37
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	37
Modulation of immunity by the secreted phospholipase A₂ family	37
Axes of heterogeneity in human tissue‐resident memory T cells	37
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	37
PANoptosis: Mechanisms, biology, and role in disease	36
Cover Image	34
	34
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	33
Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis	33
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	32
From Lymphotoxin to Tertiary Lymphoid Structures and Beyond	32
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	32
Structural Immunology of SARS‐CoV‐2	32
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	31
	31
Factor D	31
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	31
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	31
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	31
Irritable bowel syndrome: When food is a pain in the gut	30

Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	30
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	30
Host immune responses in the central nervous system during fungal infections	30
Development and organization of omental milky spots	29
Issue Information	29
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	29
Many Achilles’ heels of B and T cell tolerance	29
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	29
Cover Image	28
Cover Image	28
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	27
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	27
Innate Immunity and Asthma Exacerbations: Insights From Human Models	26
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	26
No time to die: Epigenetic regulation of natural killer cell survival	26
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	25
Low‐molecular weight inhibitors of the alternative complement pathway	25
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	25
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	25
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	25
Stability and change in epigenetic regulation of immune cells	25
Neutrophils in aging and aging‐related pathologies	25
Human Atypical B Cells. An Overview	25
Issue Information	24
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	24
Issue Information	24
	24
The nervous system during COVID‐19: Caught in the crossfire	23
ILC2 Diversity, Location, and Function in Pulmonary Disease	23
Swimming Through Dendritic Cell Biology: Insights From Fish Models	23
Ontogenetic Diversification of Type 2 Conventional Dendritic Cells in the Bone Marrow: A Central Logic for Peripheral Immunity	23
The impact of the human gut microbiome on the treatment of autoimmune disease	22
	22
The impact of neuroinflammation on neuronal integrity	22
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	22
	22
Issue Information	22
Signals that control MAIT cell function in healthy and inflamed human tissues	21
Established and emerging roles for mitochondria in neutrophils	21
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	21
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	21
Innate Immune Sensors in Health and Disease	21
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	20
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	20
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	20
Thymic Dendritic Cells Revisited	20
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	20
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	20
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	19
Life‐threatening antibodies: The discovery of anaphylaxis	19
	19
Imaging the immune system redux	19
Microbes and the fate of neutrophils	19
	19
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	18
Role of B cells in immune‐related adverse events following checkpoint blockade	18
IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies	18
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	18
Dendritic Cells in the Gastrointestinal System: Division of Labor, Plasticity, and Niche‐Specific Adaptation	18
Regulation of immune responses to food by commensal microbes	18
Copper homeostasis and cuproptosis in cancer immunity and therapy	18
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	18
Mechanosensing in Dendritic Cells	18
Additional Cover	18