OOIR: Observatory of International Research

Papers

(The TQCC of Immunological Reviews is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	235
Low‐molecular weight inhibitors of the alternative complement pathway	209
Issue Information	156
Issue Information	147
Issue Information	145
Cover Image	128
	128
Regulation of CD8 T‐cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid	111
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*	79
Epigenetics and CD8⁺ T cell memory*	79
Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells	73
The right educational environment: Oral tolerance in early life	69
Issue Information	63
Sensory sentinels: Neuroimmune detection and food allergy	62
Insights into the clinical, immunologic, and genetic underpinnings of food allergy	60
Pathogenic mechanisms in the evolution of food allergy	53
Cover Image	51
Issue Information	48
Cover Image	48
Many Achilles’ heels of B and T cell tolerance	47
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A	47
RNA regulatory mechanisms that control antiviral innate immunity	46
Cover Image	45
Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation	45
No time to die: Epigenetic regulation of natural killer cell survival	45

The resolution of phagosomes	45
Memories that last: Dynamics of memory T cells throughout the body	44
Issue Information	43
Stability and change in epigenetic regulation of immune cells	42
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	42
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	41
Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy	39
Functional genomics in inborn errors of immunity	38
The potency of hematopoietic stem cell reprogramming for changing immune tone	38
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	38
Transcriptional and epigenetic regulation in thymic epithelial cells*	37
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	36
The Effector Functions of Antibodies	35
Issue Information	35
Immunoglobulin A Antibodies: From Protection to Harmful Roles	33
Immune checkpoint inhibitors in infectious disease	32
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies	32
The function of antibodies	32
Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*	31
The neutrophil: A key resourceful agent in immune‐mediated vasculitis	31
	31
Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition	31
Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases	30
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	30
Antigen‐specific and cross‐reactive T cells in protection and disease	30
Imaging the different timescales of germinal center selection*	30
Rheumatic complications of checkpoint inhibitors: Lessons from autoimmunity	30
Issue Information	29
Nucleic acid sensing in the central nervous system: Implications for neural circuit development, function, and degeneration	29
	29
A variety of death modes of neutrophils and their role in the etiology of autoimmune diseases	28
Imaging dendritic cell functions*	28
The fibroblast: An emerging key player in thymic T cell selection	28
Age‐related macular degeneration: A disease of extracellular complement amplification	27
Role of inhibitory signaling in peripheral B cell tolerance*	27
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	26
Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells	26
Superoxide: The enigmatic chemical chameleon in neutrophil biology	26
B cells going viral in theCNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis	26
Coengineering specificity, safety, and function into T cells for cancer immunotherapy	24
N1 versus N2 and PMN‐MDSC: A critical appraisal of current concepts on tumor‐associated neutrophils and new directions for human oncology	24
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	24
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	24
Next‐generation chimeric antigen receptors for T‐ and natural killer‐cell therapies against cancer	24
Regulation of the NLRP3 inflammasome by autophagy and mitophagy	23
LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3	23
Current knowledge on the early stages of human neutropoiesis	23
Innate Immunity and Asthma Exacerbations: Insights From Human Models	23
The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunity	23
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	23

Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity	22
Signaling Activation and Modulation in Extrafollicular B Cell Responses	22
Role of inflammasomes and neuroinflammation in epilepsy	22
A Structural Voyage Toward the Landscape of Humoral and Cellular Immune Escapes of SARS‐CoV‐2	22
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	22
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma	22
Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*	22
Metabolic regulation of type I interferon production	21
Neutrophils in aging and aging‐related pathologies	21
NETosis: Sculpting tumor metastasis and immunotherapy	21
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*	21
The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids	20
Issue Information	20
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	20
	20
Routine SARS‐CoV‐2 vaccination for all children*	19
The gene regulatory network controlling plasma cell function	19
Insights into phenotypic and functional CD8⁺ T_RM heterogeneity	19
Toward the clinical development of synthetic immunity to cancer	19
The cell stress and immunity cycle in cancer: Toward next generation of cancer immunotherapy	19
Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney	18
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	18
Plasma cell biology: Foundations for targeted therapeutic development in transplantation	18
The impact of the human gut microbiome on the treatment of autoimmune disease	17
The influence of aging and the microbiome in multiple sclerosis and other neurologic diseases	17
Issue Information	17
Stem‐like T cells in cancer and autoimmunity	17
T cells in obesity‐associated inflammation: The devil is in the details	17
Surfing on the waves of the human γδ T cell ontogenic sea	16
Unique aspects of IFN‐γ/STAT1 signaling in neurons	16
Antibodies in breast milk: Pro‐bodies designed for healthy newborn development	16
Issue Information	16
Stromal cells in tertiary lymphoid structures: Architects of autoimmunity	16
Regulatory strategies limiting endosomal Toll‐like receptor activation in B cells*	16
Eras of designer Tregs: Harnessing synthetic biology for immune suppression	16
Modulation of plasmacytoid dendritic cells response in inflammation and autoimmunity	15
Transforming mutations in the development of pathogenic B cell clones and autoantibodies*	15
Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation	15
Lipid metabolism in dendritic cell biology	15
Issue Information	15
	15
Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell	15
The Evolving T Cell Receptor Recognition Code: The Rules Are More Like Guidelines	15
Transcriptomics for child and adolescent tuberculosis*	15
How RNA modifications regulate the antiviral response	15
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	15
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	15
The immune system in Down Syndrome: Autoimmunity and severe infections	15
With complements: C3 inhibition in the clinic	15
Inside the phagosome: A bacterial perspective	15
Issue Information	15
Cover Image	15
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	14
The complement alternative pathway and hemostasis	14
Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells	14
Extrinsic and intrinsic drivers of natural killer cell clonality	14
Macrophage‐fibroblast circuits in the spleen	14
Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research	14
Epigenetic gene regulation in plasma cells	14
T‐cell heterogeneity, progenitor–progeny relationships, and function during latent and chronic viral infections	14
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	14