OOIR: Observatory of International Research

Papers

(The TQCC of Immunological Reviews is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Issue Information	260
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases	229
Cover Image	177
Immune checkpoint inhibitors in infectious disease	124
Antigen‐specific and cross‐reactive T cells in protection and disease	109
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming	91
Imaging dendritic cell functions*	76
Human autoantibodies neutralizing type I IFNs: From 1981 to 2023	75
Metabolic regulation of type I interferon production	75
Superoxide: The enigmatic chemical chameleon in neutrophil biology	69
Role of inflammasomes and neuroinflammation in epilepsy	65
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance	65
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease	64
The Structural Biology of T‐Cell Antigen Detection at Close Contacts	62
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity	58
NETosis: Sculpting tumor metastasis and immunotherapy	57
Issue Information	56
B‐1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease	55
Thymic and extrathymic Aire‐expressing cells in maternal‐fetal tolerance*	54
The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity	52
With complements: C3 inhibition in the clinic	51
Allosteric Changes Underlie the Outside‐In Transmission of Activatory Signals in the TCR	50
Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria	50
The immune system in Down Syndrome: Autoimmunity and severe infections	50
The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals	48

Layered origins of lymphoid tissue inducer cells	48
Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy	48
Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation	43
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights	42
	40
Cover Image	40
An introduction to neuroimmunology	40
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*	40
Autoimmunity and the microbiome	38
Maternal influences on offspring food allergy	37
Issue Information	37
Issue Information	37
	36
Activation pathways that drive CD4⁺ T cells to break tolerance in autoimmune diseases*	36
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*	36
Sequence determinants as key regulators in gene expression of T cells	36
ZAP70, too little, too much can lead to autoimmunity*	35
Common variable immunodeficiency, cross currents, and prevailing winds	35
Cortical Thymic Epithelial Cells: Key Developers of the Code of T‐Cell Selection and TCR Repertoire Diversity	35
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy	35
Issue Information	34
Functional Insights From Immunoreceptor Structures	34
T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma	34
Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation	34
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy	33
JAK/STAT defects and immune dysregulation, and guiding therapeutic choices	32
Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*	32
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity	31
Modulation of immunity by the secreted phospholipase A₂ family	31
Axes of heterogeneity in human tissue‐resident memory T cells	30
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement	30
Deconstructing the Thymic Microenvironment Through Genesis to Senescence	30
Human neutrophils ≠ murine neutrophils: Does it matter?	30
Targeting Bottlenecks in Malaria Transmission: Antibody‐Epitope Descriptions Guide the Design of Next‐Generation Biomedical Interventions	29
MAP Kinase Signaling at the Crossroads of Inflammasome Activation	29
Correction to “The Journey Toward Disease Modification in Cow Milk Protein Allergy”	29
PANoptosis: Mechanisms, biology, and role in disease	29
Glycobiology of IgE	29
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond	28
	28
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease	28
Structural Immunology of SARS‐CoV‐2	28
Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation	28
Cover Image	27
Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma	27
Factor D	27
Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy*	27
Irritable bowel syndrome: When food is a pain in the gut	26
	26
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis	25

Development and organization of omental milky spots	25
Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health	25
Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases	25
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A	25
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system	24
Issue Information	24
Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease	24
Cover Image	24
Host immune responses in the central nervous system during fungal infections	24
Many Achilles’ heels of B and T cell tolerance	24
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?	24
Transcriptional and epigenetic regulation in thymic epithelial cells*	23
Immunogenicity and efficacy of Ad26.COV2.S: An adenoviral vector–based COVID‐19 vaccine	23
No time to die: Epigenetic regulation of natural killer cell survival	23
Alternative pathway activation in pregnancy, a measured amount “complements” a successful pregnancy, too much results in adverse events	23
Low‐molecular weight inhibitors of the alternative complement pathway	23
Cover Image	23
Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*	23
Stability and change in epigenetic regulation of immune cells	22
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment	22
Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology	22
Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?	21
Issue Information	21
Neutrophils in aging and aging‐related pathologies	21
Issue Information	21
Innate Immunity and Asthma Exacerbations: Insights From Human Models	21
The nervous system during COVID‐19: Caught in the crossfire	20
Contributions of animal models to mechanistic understandings of antibody‐dependent disease and roles of the amplification loop	20
	20
ILC2 Diversity, Location, and Function in Pulmonary Disease	19
The impact of neuroinflammation on neuronal integrity	19
The evolving landscape of immune‐related adverse events that follow immune checkpoint immunotherapy in cancer patients	19
Visualization and functional characterization of lymphoid organ fibroblasts*	19
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*	19
	19
The impact of the human gut microbiome on the treatment of autoimmune disease	19
Regnase‐1–related endoribonucleases in health and immunological diseases	19
Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: Current understanding and future directions	18
Microbes and the fate of neutrophils	18
Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent*	18
Signals that control MAIT cell function in healthy and inflamed human tissues	18
	18
Established and emerging roles for mitochondria in neutrophils	18
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death	18
Imaging leukocyte migration through afferent lymphatics*	18
Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo	18
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond	18
Innate Immune Receptors as Dynamic Modulators of Extrafollicular Autoimmune B Cell Response	17
Innate Immune Sensors in Health and Disease	17
Issue Information	17
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated functions	17
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies	16
Additional Cover	16
Imaging the immune system redux	16
Regulation of immune responses to food by commensal microbes	16
	16
Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches	16
Role of B cells in immune‐related adverse events following checkpoint blockade	16
Life‐threatening antibodies: The discovery of anaphylaxis	16
Correction to “The anti‐inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids”	16
Chemo‐ and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen*	16