OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology Letters is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Influence of affinity tags and tobacco PR1a signal peptide on detection, purification and bioactivity analyses of the small oomycete apoplastic effectors	82
Listeria monocytogenes is a solvent tolerant organism secreting a solvent stable lipase: potential biotechnological applications	35
Activation of galactose utilization by the addition of glucose for the fermentation of agar hydrolysate using Lactobacillus brevis ATCC 14869	32
Cell density detection based on a microfluidic chip with two electrode pairs	30
Enhancement of riboflavin production in Bacillus subtilis via in vitro and in vivo metabolic engineering of pentose phosphate pathway	29
Silica nanoparticles enhance interfacial self-adherence of a multi-layered extracellular matrix scaffold for vascular tissue regeneration	29
Synthesis of β-ionone from xylose and lignocellulosic hydrolysate in genetically engineered oleaginous yeast Yarrowia lipolytica	28
Recombinant expression, downstream optimization, and therapeutic evaluation of recombinant human interleukin-37 for cancer therapy	28
Anaerobic biofilm enriched with an ammonia tolerant methanogenic consortium to improve wastewater treatment in the fishing industry	24
Directed evolution of cholesterol oxidase with improved thermostability using error-prone PCR	24
Unraveling the molecular mechanisms of selenite reduction: transcriptomic analysis of Bacillus reveals the key role of sulfur assimilation	23
The pedal-like loop of (R)-selective transaminases plays a critical role to the functionality of the enzyme	20
Design and application of expression constructs for FMDV serotype O structural proteins	17
Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells	17
Efficient immobilization behavior and mechanism investigation of Pb(II) by Aspergillus tubingensis	16
Synergistic anticancer effects of interleukin-21 combined with therapeutic peptides in multiple cancer cells	15
Squalene hopene cyclases and oxido squalene cyclases: potential targets for regulating cyclisation reactions	15
Application of exogenous melatonin in vitro and in planta: a review of its effects and mechanisms of action	15
Application of lactose based autoinduction for heterologous production of an active [NiFe] hydrogenase in E. coli	15
Retraction Note: Autophagy regulated by lncRNA HOTAIR contributes to the cisplatin-induced resistance in endometrial cancer cells	14
Biocontrol of strawberry Botrytis gray mold and prolong the fruit shelf-life by fumigant Trichoderma spp.	14
Identification of laccase genes in Trichoderma asperellum Ts93	13
Metabolic response of Bacillus spp. to heavy metal stress: pathway alterations and metabolite profiles	12
Retraction Note: TP53INP1 3′-UTR functions as a ceRNA in repressing the metastasis of glioma cells by regulating miRNA activity	12
Clinical and mechanistic insights into biomedical application of Se-enriched probiotics and biogenic selenium nanoparticles	12

Isolation, microscopic and magnetotactic characterization of Magnetospirillum moscoviense MS-24 from Banjosa Lake, Pakistan	12
Production of flavonol and flavone 6-C-glucosides by bioconversion in Escherichia coli expressing a C-glucosyltransferase from wasabi (Eutrema japonicum)	12
Succession from acetoclastic to hydrogenotrophic microbial community during sewage sludge anaerobic digestion for bioenergy production	11
Therapeutic potential of a novel IP-10-(anti-HER2 scFv) fusion protein for the treatment of HER2-positive breast cancer	11
Calumenin knockdown, by intronic artificial microRNA, to improve expression efficiency of the recombinant human coagulation factor IX	11
Cellulase and chitinase activities and antagonism against Fusarium oxysporum f.sp. cubense race 1 of six Trichoderma strains isolated from Mexican maize cropping	10
Gallic acid as biofilm inhibitor can improve transformation efficiency of Ruminiclostridium papyrosolvens	10
BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1	10
Magnetic particle-based chemiluminescence immunoassay for serum human heart-type fatty acid binding protein measurement	10
Substrate type and CO2 addition significantly influence succinic acid production of Basfia succiniciproducens	10
The modification of heme special importer to improve the production of active hemoglobins in Escherichia coli	10
Research on the application of heterotrophic nitrification-aerobic denitrification bacteria in membrane bioreactor (MBR)	10
Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells	10
An artificial multienzyme cascade for the whole-cell synthesis of rare ketoses from glycerol	9
Toxicants improve glycerol production in the fermentation of undetoxified hydrolysate by Candida glycerinogenes	9
Improving the specific activity and stability of alkaline pectinase PEL3 through SpyTag/SpyCatcher cyclization	9
Aptamer-functionalized MOFs and AI-driven strategies for early cancer diagnosis and therapeutics	9
Characterization of a novel Escherichia coli recombineering selection/counterselection cassette	9
Micro-electrochemical DO sensor with ultra-micropore matrix fabricated with femtosecond laser processing successfully applied in on-line DO monitoring for yeast culture	9
Construction of a bacteriophage-derived vector with potential applications in targeted drug delivery and cell imaging	9
Rapid and cost-effective screening of CRISPR/Cas9-induced mutants by DNA-guided Argonaute nuclease	9
Development of a synthetic transcription factor-based S-adenosylmethionine biosensor in Saccharomyces cerevisiae	8
Application of low-intensity ultrasound to enhance simultaneous nitrification/iron-based autotrophic denitrification	8
Bone marrow mesenchymal stem cell-derived exosomes loaded with miR-26a through the novel immunomodulatory peptide DP7-C can promote osteogenesis	8
Exploration of a three-dimensional matrix as micro-reactor in the form of reactive polyaminosaccharide hydrogel beads using multipoint covalent interaction approach	8
Application of CRISPR-Cas9 in microbial cell factories	8
The variation of microorganisms and organics during methane production from lignite under an electric field	7
Genome-scale metabolic model-based engineering of Escherichia coli enhances recombinant single-chain antibody fragment production	7
A critical appraisal of humanized alternatives to fetal bovine serum for clinical applications of umbilical cord derived mesenchymal stromal cells	7
Simple stain-free screening method for pectinolytic microorganisms under alkalophilic conditions	7
Investigation of osteogenesis and angiogenesis in perfusion bioreactors using improved multi-layer PCL-nHA-nZnO electrospun scaffolds	7
Differentiation, maturation, and collection of THP-1-derived dendritic cells based on a PEG hydrogel culture platform	7
Enhancement of cordycepin production from Cordyceps militaris culture by epigenetic modification	7
Mutational analysis of pig tissue factor pathway inhibitor α to increase anti-coagulation activity in pig-to-human xenotransplantation	7
Trichoderma longibrachiatum and thermothelomyces thermophilus co-culture: improvement the saccharification profile of different sugarcane bagasse varieties	7
Economic optimization of expression of soluble human epidermal growth factor in Escherichia coli	7
Transcriptome expression profiles reveal response mechanisms to drought and drought-stress mitigation mechanisms by exogenous glycine betaine in maize	7
Dynamic cultivation of human mesenchymal stem/stromal cells for the production of extracellular vesicles in a 3D bioreactor system	7
Identification, molecular and biochemical characterization of a novel thermoactive and thermostable glucoamylase from Thermoanaerobacter ethanolicus	7
Correction to: Multilineage differentiation of muscle-derived stem cells from GFP transgenic mice	6
Food-grade γ-aminobutyric acid production by immobilized glutamate decarboxylase from Lactobacillus plantarum in rice vinegar and monosodium glutamate system	6
Effects of the deletion and substitution of thioesterase on bacillomycin D synthesis	6
Biotransformation of C20- and C22-polyunsaturated fatty acids to 11S- and 13S-hydroxy fatty acids by Escherichia coli expressing 11S-lipoxygenase from Enhygromyxa salina	6
Preparation of white rot fungal inoculum and its application to bioremediation of chlorimuron-ethyl-contaminated soil	6
Competitive inhibition of a non-natural cofactor dependent formaldehyde dehydrogenase by imidazole	6
Biogenesis and characterization of proficient silver nanoparticles employing marine procured fungi Hamigera pallida and assessment of their antioxidative, antimicrobial and anticancer potency	6
Advanced biotechnology using methyltransferase and its applications in bacteria: a mini review	6
Molecular cloning and characterization of an alpha-amylase inhibitor (TkAAI) gene from Trichosanthes kirilowii Maxim.	6
Carrier immobilization and auto-exposition favoring reuse of silyletherase SilE-R from Brassica sp. with high activity and enantiospecificity	6
A gold nanoparticles-based lateral flow assay utilizing baculovirus expressed recombinant nucleocapsid and receptor binding domain proteins for serodetection of IgG and IgM against SARS-CoV-2	6

Engineering a synthesis-friendly serum responsive promoter for antibiotic selection of genomic integration in cell-based therapy	6
Expansion of YALIcloneHR toolkit for Yarrowia lipolytica combined with Golden Gate and CRISPR technology	6
Optimizing microbial electrolysis cell performance: strategies to mitigate electron mediator degradation on membranes	6
Establishment of a visual gene knockout system based on CRISPR/Cas9 for the rare actinomycete Nonomuraea gerenzanensis	6
Cost-effective production of squalene using Yarrowia lipolytica via metabolic engineering and fermentation engineering	6
CRISPR/Cas9-assisted ssDNA recombineering for site-directed mutagenesis and saturation mutagenesis of plasmid-encoded genes	6
Current advances and future prospects in production of recombinant insulin and other proteins to treat diabetes mellitus	6
A cell-free fluorescence biosensor based on allosteric transcription factor NalC for detection of pentachlorophenol	6
Pilot-scale production of Bacillus subtilis MSCL 897 spore biomass and antifungal secondary metabolites in a low-cost medium	6
Homo- and heterofermentative lactobacilli are distinctly affected by furanic compounds	6
Optimization of ultrasound-assisted production of ergosterol from Penicillium brevicompactum by Taguchi statistical method	6
Improving the hydrophilic microenvironment surrounding the catalytic site of fructosyltransferase enhances its catalytic ability	6
Isolation and characterisation of exosomes from Chinese hamster ovary (CHO) cells	6
Antimicrobial activity of thermophilin 110 against the opportunistic pathogen Cutibacterium acnes	6
Antigenic and conserved peptides from diverse Helicobacter pylori antigens	5
Synthesis of di-rhamnolipids by the avirulent, mono-rhamnolipid producing strain Pseudomonas aeruginosa ATCC 9027	5
From yeast screening for suitability as single cell protein to fed-batch cultures	5
Efficient and high-density immobilization of animal cells by a microfiber with both swelling and cell adhesion properties and its application to exosome production	5
Development of an animal-derived component-free medium for Spodoptera frugiperda (Sf9) cells using response surface methodology	5
Roles of PKAc1 and CRE1 in cellulose degradation, conidiation, and yellow pigment synthesis in Trichoderma reesei QM6a	5
RETRACTED ARTICLE: Characterization of a new bacteriocin-like inhibitory peptide produced by Lactobacillus sakei B-RKM 0559	5
Improvement of transglutaminase production by controlling the morphology of Streptomyces mobaraensis HVCP-Sm1 with microparticle-enhanced cultivation	5
Enhanced activity of hyperthermostable Pyrococcus horikoshii endoglucanase in superbase ionic liquids	5
Completely noninvasive multi-analyte monitoring system for cell culture processes	5
Antibiotic-free production of sucrose isomerase in Bacillus subtilis by genome integration	5
Monitoring of a microbial community during bioaugmentation with hydrogenotrophic methanogens to improve methane yield of an anaerobic digestion process	5
ANCUT1, a novel thermoalkaline cutinase from Aspergillus nidulans and its application on hydroxycinnamic acids lipophilization	5
Supplementation of articular cartilage-derived chondroprogenitors with bone morphogenic protein-9 enhances chondrogenesis without affecting hypertrophy	5
swnk plays an important role in the biosynthesis of swainsonine in Metarhizium anisopliae	5
GH2 family β-galactosidases evolution using degenerate oligonucleotide gene shuffling	5
Enhanced soluble expression of active recombinant human interleukin-29 using champion pET SUMO system	5
Retraction Note: Characterization of a new bacteriocin-like inhibitory peptide produced by Lactobacillus sakei B-RKM 0559	5
Integrated bioinformatics based subtractive genomics approach to decipher the therapeutic function of hypothetical proteins from Salmonella typhi XDR H-58 strain	5
Production enhancement of the glycopeptide antibiotic A40926 by an engineered Nonomuraea gerenzanensis strain	5
An inducible Komagataella phaffii system for protein expression using sorbitol dehydrogenase promoter	5
Recombinant AcMNPV-gp64-EGFP and synergist triphenyl phosphate, an effective combination against Spodoptera frugiperda	5
Improving pharmacological activities of thrombopoietin mimetic peptide by genetic fusion to albumin-binding domain	5
WAVE-based intensified perfusion cell culture for fast process development	5
Exploring potential bacterial populations for enhanced anthraquinone dyes biodegradation: a critical review	5
Anti-inflammatory potential of baicalein combined with silk fibroin protein in a zebrafish model (Danio rerio)	5
Citrus essential oil: would it be feasible as antimicrobial in the bioethanol industry?	5
Redifferentiation of genetically modified dedifferentiated chondrocytes in a microcavitary hydrogel	5
A novel thermophilic β-carotene 15,15′-monooxygenase with broad substrate specificity from the marine bacterium Candidatus Pelagibacter sp. HTCC7211	5
Application of three-dimensional cell culture technology in screening anticancer drugs	5
Regulation of fadR on the ROS defense mechanism in Shewanalla oneidensis	5
Statistical optimization of thermostable alkaline protease from Bacillus cereus KM 05 using response surface methodology	5