Biopharmaceutics & Drug disPosition

Article	Citations
Can a monthly exenatide extended release regimen provide a therapeutic and cost benefit?	19
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Irinotecan‐induced gastrointestinal damage alters the expression of peptide transporter 1 and absorption of cephalexin in rats	16
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In situ evaluation of the impact of metformin or verapamil coadministration with vildagliptin on its regional absorption from the rabbit’s intestine	11
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Febuxostat and its major acyl glucuronide metabolite are potent inhibitors of organic anion transporter 3: Implications for drug‐drug interactions with rivaroxaban	10
Comparison of biomarker and chromatographic analytical approaches to pharmacokinetic study of sitagliptin	10
Decreased plasma exposure of clopidogrel active metabolite in rats after long‐term treatment with clopidogrel	8
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Norvancomycin plasma concentration monitoring in hemodialysis patients with end stage kidney disease: A retrospective cohort study	8
Metabolism of testosterone and progesterone by cytochrome P450 2C19 allelic variants	8
Heterogeneous brain distribution of bumetanide following systemic administration in rats	7
Icaritin exhibits potential drug–drug interactions through the inhibition of human UDP‐glucuronosyltransferase in vitro	7
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Physiologically based pharmacokinetic modelling of acetaminophen in preterm neonates—The impact of metabolising enzyme ontogeny and reduced cardiac output	6
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Changes in uridine 5′‐diphospho‐glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid	6
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Influence of Gegenqinlian decoction on pharmacokinetics and pharmacodynamics of saxagliptin in type 2 diabetes mellitus rats	5
In Vivo Animal Spices and Experimental Technique to Evaluate Sustained Release Granules	5
Pharmacokinetic control of orally dosed cyclosporine A with mucosal drug delivery system	5
In vitro and ex vivo experimental models for evaluation of intranasal systemic drug delivery as well as direct nose‐to‐brain drug delivery	5
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Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3‐selective GABAkine KRM‐II‐81	4
In vitro evaluation of 99mTc‐sultamicillin for infection imaging	4
Profiling pharmacokinetics of double‐negative T cells and cytokines via a single intravenous administration in NSG mice	4
Aging and brain free cholesterol concentration on amyloid‐β peptide accumulation in guinea pigs	4
Comparison of tissue pharmacokinetics of esflurbiprofen plaster with flurbiprofen tablets in patients with knee osteoarthritis: A multicenter randomized controlled trial	4
Regional distributions of curcumin and tetrahydrocurcumin in the liver and small intestine of rats when orally co‐administered with quercetin and paeoniflorin	4
Investigating CNS distribution of PF‐05212377, a P‐glycoprotein substrate, by translation of 5‐HT6 receptor occupancy from non‐human primates to humans	4
When special populations intersect with drug–drug interactions: Application of physiologically‐based pharmacokinetic modeling in pregnant populations	3
Decreased plasma acetaminophen glucuronide/acetaminophen concentration ratio warns the onset of acetaminophen‐induced liver injury	3
The application of precision dosing in the use of sertraline throughout pregnancy for poor and ultrarapid metabolizer CYP 2C19 subjects: A virtual clinical trial pharmacokinetics study	3
Clinical application of vancomycin population pharmacokinetics model in patients with hematological diseases and neutropenia	3
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Linking in vitro–in vivo extrapolations with physiologically based modeling to inform drug and formulation development	3
Absorption, metabolism, and pharmacokinetic profile of xanthohumol in rats as determined via UPLC‐MS/MS	3
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Effect of hepar‐protecting Wuzhi capsule on pharmacokinetics and dose‐effect character of tacrolimus in healthy volunteers	3
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In vitro–in vivo extrapolation of bexarotene metabolism in the presence of chronic kidney disease and acute kidney injury in rat using physiologically based pharmacokinetic modeling and extrapo	3
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Species Differences in Carboxylesterases Among Humans, Cynomolgus Monkeys, and Mice in the Hydrolysis of Atorvastatin Derivatives	2
Evaluation on absorption risks of amentoflavone after oral administration in rats	2
Drug‐drug interaction between diclofenac and gamma‐hydroxybutyric acid	2
Computational exploration of microsomal cytochrome P450 3A1 enzyme modulation by phytochemicals ofCichorium intybusL.: Insights into drug metabolism	2
Nanocrystal solid dispersion of fuzapladib free acid with improved oral bioavailability	2
Inhibition of canalicular and sinusoidal taurocholate efflux by cholestatic drugs in human hepatoma HepaRG cells	2
Evaluation of bottom‐up modeling of the blood–brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling	2
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Model‐informed drug development: The mechanistic HSK3486 physiologically based pharmacokinetic model informing dose decisions in clinical trials of specific populations	1
Exploring in vitro solubility of lamotrigine in physiologically mimetic conditions to prospect the in vivo dissolution in pediatric population	1
Self‐micellizing solid dispersion of tacrolimus: Physicochemical and pharmacokinetic characterization	1
Gender difference in the pharmacokinetics and metabolism of VX‐548 in rats	1
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Integration of artificial neural network and physiologically based biopharmaceutic models in the development of sustained‐release formulations	1
Characterization of AST‐001 non‐clinical pharmacokinetics: A novel selective AKR1C3‐activated prodrug in mice, rats, and cynomolgus monkeys	1
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In vitro and in silico interactions of antiulcer, glucocorticoids and urological drugs on human carbonic anhydrase I and II isozymes	1
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Evaluation of sex differences in the pharmacokinetics of oral sumatriptan in healthy Korean subjects using population pharmacokinetic modeling	1
Intestinal absorption pathways of lisinopril: Mechanistic investigations	1
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Vicagrel is hydrolyzed by Raf kinase inhibitor protein in human intestine	0
A limited sampling model to estimate the area under the curve of mycophenolic acid in hematopoietic stem cell transplantation recipients	0

Utility of cystatin C and serum creatinine‐based glomerular filtration rate equations in predicting vancomycin clearance: A population pharmacokinetics analysis in elderly Chinese patients	0
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Enhanced oral bioavailability of capsaicin‐loaded microencapsulation complex via electrospray technology: Preparation, in vitro and in vivo evaluation	0
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In vitro and In silico biopharmaceutic regulatory guidelines for generic bioequivalence for oral products: Comparison among various regulatory agencies	0
Application of Physiologically Based Pharmacokinetic Model to Compare the Biodistribution of Liposomal Amphotericin B With Conventional Amphotericin B Deoxycholate in Humans	0
Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage	0
Self‐emulsifying drug delivery system of (R)‐α‐lipoic acid to improve its stability and oral absorption	0
Physiologically‐based pharmacokinetic model for alectinib, ruxolitinib, and panobinostat in the presence of cancer, renal impairment, and hepatic impairment	0
Population pharmacokinetics of oral levofloxacin in healthy volunteers and dosing optimization for multidrug‐resistant tuberculosis therapy	0
Evidence for cytochrome P450 3A4‐mediated metabolic activation of SCO‐267	0
Coming full circle: The potential utility of real‐world evidence to discern predictions from a physiologically based pharmacokinetic model	0
Selective inhibitory effects of suberosin on CYP1A2 in human liver microsomes	0
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Attenuation of phenobarbital‐induced cytochrome P450 expression in carbon tetrachloride‐induced hepatitis in mice models	0
Nanostructured Lipid Carriers‐Based Topical Gel of Betulinic Acid: In Vitro, In Vivo Evaluation and Dermatokinetic Analysis	0
Metabolic interaction between biflavonoids in Ginkgo biloba leaves and tacrolimus	0
In‐depth analysis of patterns in selection of different physiologically‐based pharmacokinetic modeling tools: Part II — Assessment of model reusability and comparison between open and non‐open source‐	0
Quantitative analysis of the impact of membrane permeability on intestinal first‐pass metabolism of CYP3A substrates	0
Enalapril increases the urinary excretion of metformin in rats by inducing multidrug and toxin excretion protein 1 in the kidney	0
In vivo monitoring of brain pharmacokinetics and pharmacodynamics with cerebral open flow microperfusion	0
Physiologically based pharmacokinetic modeling and simulations to inform dissolution specifications and clinical relevance of release rates on elagolix exposure	0
Shared learning from a physiologically based pharmacokinetic modeling strategy for human pharmacokinetics prediction through retrospective analysis of Genentech compounds	0
Evaluation of bleeding and anticoagulation markers by edoxaban and low‐dose cyclosporine: A case series study	0
Special issue on applications of in vitro, in vivo, and modeling and simulation tools for central nervous system drug disposition	0
Metabolism and pharmacokinetic study of deuterated osimertinib	0
Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l‐lactate transport in the hepatocellular carcinoma cell line	0
Model‐based interspecies interpretation of botulinum neurotoxin type A on muscle‐contraction inhibition	0
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Influence of piperine and omeprazole on the regional absorption of Daclatasvir from rabbit intestine	0
Association between α‐defensin 5 and the expression and function of P‐glycoprotein in differentiated intestinal Caco‐2 cells	0
Develop adult extrapolation to pediatrics and pediatric dose optimization based on the physiological pharmacokinetic model of azithromycin	0
Effects of aged garlic and ginkgo biloba extracts on the pharmacokinetics of sofosbuvir in rats	0
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Transition of average drug‐to‐antibody ratio of trastuzumab deruxtecan in systemic circulation in monkeys using a hybrid affinity capture liquid chromatography‐tandem mass spectrometry	0
Simulation of febuxostat pharmacokinetics in healthy subjects and patients with impaired kidney function using physiologically based pharmacokinetic modeling	0
Recent advances in the in vitro and in vivo methods to assess impact of P‐glycoprotein and breast cancer resistance protein transporters in central nervous system drug disposition	0
Physiologically based pharmacokinetic model to predict drug concentrations of breast cancer resistance protein substrates in milk	0
Achieving a low human dose for targeted covalent drugs: Pharmacokinetic and pharmacodynamic considerations on target characteristics and drug attributes	0
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Blood retinal barrier and ocular pharmacokinetics: Considerations for the development of oncology drugs	0
Optimizing transcardial perfusion of small molecules and biologics for brain penetration and biodistribution studies in rodents	0
Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β‐amyloid peptide accumulation in mice	0
Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: Advances, challenges, and future perspectives	0
Effect of ABCB1 gene variants on rivaroxaban pharmacokinetic and hemorrhage events occurring in patients with non‐valvular atrial fibrillation	0
Favipiravir biotransformation in liver cytosol: Species and sex differences in humans, monkeys, rats, and mice	0
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Predicting transporter mediated drug–drug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where we are now and the way forward	0
Pregnenolone Sulfate Permeation at the Blood–Brain Barrier is Independent of OATP2B1—In Vivo and In Vitro Insights	0
An Optimised Mobilenet V2 Attention Parallel Network for Predicting Drug–Drug Interactions Through Combining Local and Global Features	0
Exploring the Potential of Nasal Drug Delivery for Brain Targeted Therapy: A Detailed Analysis	0
Evaluating gender effect in the generic bioequivalence studies by physiologically based pharmacokinetic modeling – A case study of dextromethorphan modified release tablets	0
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In‐depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: Part I – Applications and rationale behind the use of open source‐code software	0
The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discovery	0
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Comparative in silico prediction of P‐glycoprotein‐mediated transport for 2010–2020 US FDA‐approved drugs using six Web‐tools	0
Pharmacokinetic–pharmacodynamic modeling for hepatic delivery and efficacy of antisense oligonucleotides with lipophilic ligands in mice	0
Prediction of basic drug exposure in milk using a lactation model algorithm integrated within a physiologically based pharmacokinetic model	0
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Special issue on applications of modeling and simulation in pharmaceutical drug development	0
Population pharmacokinetics of tacrolimus in Chinese adult liver transplant patients	0
Scientific considerations to move towards biowaiver for biopharmaceutical classification system class III drugs: How modeling and simulation can help	0
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Estimation of fraction of drug metabolism by a single UDP‐glucuronosyl transferase enzyme using relative expression factor	0
Physiologically‐based pharmacokinetic/pharmacodynamic modeling to predict tumor growth inhibition and the efficacious dose of selective estrogen receptor degraders in humans	0
Switchability and minimal effect of food on pharmacokinetics of modified release tablet strengths of omecamtiv mecarbil, a cardiac myosin activator	0
Pharmacokinetic–pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells	0
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Prediction of a clinically effective dose of THY1773, a novel V1Breceptor antagonist, based on preclinical data	0
Identification and characterization of an endogenous biomarker of the renal vectorial transport (OCT2‐MATE1)	0
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Kinetic analysis of cystine uptake and inhibition pattern of sulfasalazine in A549 cells	0

Effect of Nigella sativa oil on pharmacokinetics and pharmacodynamics of gliclazide in rats

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