OOIR: Observatory of International Research

Papers

(The H4-Index of Biomaterials is 87. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy	398
ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds	394
Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing	247
Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment	241
Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization	229
Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner	211
Au2Pt-PEG-Ce6 nanoformulation with dual nanozyme activities for synergistic chemodynamic therapy / phototherapy	209
A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion	196
A novel “hot spring”-mimetic hydrogel with excellent angiogenic properties for chronic wound healing	192
Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties	189
Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration	186
Polydopamine-coated nucleic acid nanogel for siRNA-mediated low-temperature photothermal therapy	184
Extracellular vesicles: A bright star of nanomedicine	178
M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages	177
Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator	175
Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke	172
Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy	170
4D-bioprinted silk hydrogels for tissue engineering	169
Bioinspired exosome-like therapeutics and delivery nanoplatforms	161
Application of conductive PPy/SF composite scaffold and electrical stimulation for neural tissue engineering	160
Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy	158
PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation	157
Microfluidic formulation of nanoparticles for biomedical applications	156
Rapid printing of bio-inspired 3D tissue constructs for skin regeneration	153
Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy	149

Tumor extravasation and infiltration as barriers of nanomedicine for high efficacy: The current status and transcytosis strategy	148
Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors	148
The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration	147
Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem	144
NIR-II bioimaging of small organic molecule	142
Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy	142
Injectable redox and light responsive MnO2 hybrid hydrogel for simultaneous melanoma therapy and multidrug-resistant bacteria-infected wound healing	140
Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration	138
Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice	132
Modulation of macrophages by bioactive glass/sodium alginate hydrogel is crucial in skin regeneration enhancement	128
Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy	127
Advances and perspectives in carrier-free nanodrugs for cancer chemo-monotherapy and combination therapy	127
Defect modified zinc oxide with augmenting sonodynamic reactive oxygen species generation	126
3D bioprinted neural tissue constructs for spinal cord injury repair	124
Bioorthogonal-targeted 1064 nm excitation theranostic nanoplatform for precise NIR-IIa fluorescence imaging guided efficient NIR-II photothermal therapy	123
Bioinspired stratified electrowritten fiber-reinforced hydrogel constructs with layer-specific induction capacity for functional osteochondral regeneration	120
PRP-chitosan thermoresponsive hydrogel combined with black phosphorus nanosheets as injectable biomaterial for biotherapy and phototherapy treatment of rheumatoid arthritis	117
Gut-on-a-chip: Current progress and future opportunities	116
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system	115
Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages	115
A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization	114
‘Green’ nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases	114
Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor-activated Smad pathway	113
Infection microenvironment-activated nanoparticles for NIR-II photoacoustic imaging-guided photothermal/chemodynamic synergistic anti-infective therapy	111
Intelligent MoS2–CuO heterostructures with multiplexed imaging and remarkably enhanced antitumor efficacy via synergetic photothermal therapy/ chemodynamic therapy/ immunotherapy	111
Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration	108
A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy	107
Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation	107
Cryogel/hydrogel biomaterials and acupuncture combined to promote diabetic skin wound healing through immunomodulation	105
Infection microenvironment-related antibacterial nanotherapeutic strategies	105
Hyaluronic acid and chondroitin sulfate (meth)acrylate-based hydrogels for tissue engineering: Synthesis, characteristics and pre-clinical evaluation	105
Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand	104
Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids	104
Biomimetic CoO@AuPt nanozyme responsive to multiple tumor microenvironmental clues for augmenting chemodynamic therapy	104
Phagocyte-membrane-coated and laser-responsive nanoparticles control primary and metastatic cancer by inducing anti-tumor immunity	103
NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens	103
Resolution of inflammation in bone regeneration: From understandings to therapeutic applications	103
Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy	103
MOF-encapsulated nanozyme enhanced siRNA combo: Control neural stem cell differentiation and ameliorate cognitive impairments in Alzheimer's disease model	103
Functionalized 3D-printed silk-hydroxyapatite scaffolds for enhanced bone regeneration with innervation and vascularization	103
Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges	102
Free radicals for cancer theranostics	101
An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging	100
How microbes read the map: Effects of implant topography on bacterial adhesion and biofilm formation	100
Biodegradable Poly(γ-glutamic acid)@glucose oxidase@carbon dot nanoparticles for simultaneous multimodal imaging and synergetic cancer therapy	99
Fabrication of polyphenol-incorporated anti-inflammatory hydrogel via high-affinity enzymatic crosslinking for wet tissue adhesion	98
Polymeric nanoparticle vaccines to combat emerging and pandemic threats	96
The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord	96
Microenvironment-driven sequential ferroptosis, photodynamic therapy, and chemotherapy for targeted breast cancer therapy by a cancer-cell-membrane-coated nanoscale metal-organic framework	95
Near-infrared-II activated inorganic photothermal nanomedicines	94

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor	94
Site-specific MOF-based immunotherapeutic nanoplatforms via synergistic tumor cells-targeted treatment and dendritic cells-targeted immunomodulation	93
Near-infrared light II - assisted rapid biofilm elimination platform for bone implants at mild temperature	91
Photothermal conversion-coordinated Fenton-like and photocatalytic reactions of Cu2-xSe-Au Janus nanoparticles for tri-combination antitumor therapy	90
Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm	90
Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration	90
AIEgens for microbial detection and antimicrobial therapy	89
Tunable bioactivity and mechanics of collagen-based tissue engineering constructs: A comparison of EDC-NHS, genipin and TG2 crosslinkers	89
Tough magnesium phosphate-based 3D-printed implants induce bone regeneration in an equine defect model	88
MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway	88
High-quality milk exosomes as oral drug delivery system	87
Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration	87
Fucoidan-based, tumor-activated nanoplatform for overcoming hypoxia and enhancing photodynamic therapy and antitumor immunity	87
Chitosan hydrogel/3D-printed poly(ε‐caprolactone) hybrid scaffold containing synovial mesenchymal stem cells for cartilage regeneration based on tetrahedral framework nucleic acid recruitment	87
Core-shell structured upconversion nanocrystal-dendrimer composite as a carrier for mitochondria targeting and catalase enhanced anti-cancer photodynamic therapy	87
3D anisotropic photocatalytic architectures as bioactive nerve guidance conduits for peripheral neural regeneration	87
Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy	87
A NIR light triggered disintegratable nanoplatform for enhanced penetration and chemotherapy in deep tumor tissues	87
An exosome-like programmable-bioactivating paclitaxel prodrug nanoplatform for enhanced breast cancer metastasis inhibition	87