International Endodontic Journal

Article	Citations
Clinical outcome of guided endodontics versus freehand drilling: Comment	239
Immunomodulatory effect of IL‐1RA in LPS‐activated macrophage/dental pulp stem cells co‐culture	195
Targeting hexokinase 1 alleviates NLRP3‐mediated inflammation in apical periodontitis: A laboratory investigation	161
Lipopolysaccharides and hydrogen peroxide induce contrasting pathological conditions in dental pulpal cells	142
Outcome measures to assess the effectiveness of endodontic treatment for pulpitis and apical periodontitis for use in the development of European Society of Endodontology S3‐level clinical practice gu	118
The shaping ability of WaveOne Gold, TRUShape and XP‐endo Shaper systems in oval‐shaped distal canals of mandibular molars: A microcomputed tomographic analysis	89
Exploring approaches to pulp vitality assessment: A scoping review of nontraditional methods	83
Substance P/calcitonin gene‐related peptide and their receptors expression in human periodontal ligament after root canal preparation with five different systems	82
The financial and quality of life impact of urgent dental presentations: A cross‐sectional study	78
IWP‐2 modulates the immunomodulatory properties of human dental pulp stem cells in vitro	76
Activin a regulates vascular formation and stabilization in direct coculture of dental pulp stem cells and endothelial cells	76
Top 100 most‐cited scientific articles in regenerative endodontics 2019–2023: A bibliometric analysis	74
Inflammatory profile of apical periodontitis exacerbated by cigarette smoke inhalation: Histological and immunohistochemical analysis in rats	70
Precision‐milled simulated curved root canals in bovine dentine for the assessment of chemo‐mechanical root canal preparation	65
A critical analysis of research methods and experimental models to study irrigants and irrigation systems	64
Effect of kinematics on the torque/force generation, surface characteristics, and shaping ability of a nickel‐titanium rotary glide path instrument: An ex vivo study	64
Gender diversity in endodontics: Women's representation at recent biennial meetings	62
Micro‐CT evaluation of a nanodiamond irrigant for hard‐tissue debris removal during sonic agitation	59
Issue Information	59
Angiogenic and neurogenic potential of dental‐derived stem cells for functional pulp regeneration: A narrative review	59
Response to the letter regarding our article, ‘Potential predisposing features of external cervical resorption: An observational study’ (Patel et al., 2025)	56
Micro‐computed tomographic evaluation of dentinal microcracks in response to progressive taper enlargement in root canals of maxillary molars	55
Selenium ameliorates inflammation by decreasing autophagic flux and mitogen‐activated protein kinase signalling on experimentally induced rat periapical lesions	53
The use of electrodermal activity in pulpal diagnosis and dental pain assessment	53
Success rate of orthograde endodontic retreatment after failed apicectomy – A retrospective study	52

Expression of chronic pain genes in apical periodontitis tissues	51
Volumetric changes in root canal sealers in ex vivo and a novel animal model approach	51
Periapical healing following endodontic microsurgery with collagen‐based bone‐filling material: A randomized controlled clinical trial	50
New consultant statistical advisor	50
The impact of an enhanced infection control protocol on molar root canal treatment outcome – a randomized clinical trial	47
Influence of dental bleaching on the pulp tissue: A systematic review of in vivo studies	47
In‐depth investigation of FAM20A insufficiency effects on deciduous dental pulp cells: Altered behaviours, osteogenic differentiation, and inflammatory gene expression	46
Influence of ethylenediaminetetraacetic acid on regenerative endodontics: A systematic review	45
Present status and future directions—Vital pulp treatment and pulp preservation strategies	43
Issue Information	43
Single nucleotide polymorphisms as a predisposing factor for the development of apical periodontitis—An umbrella review	41
Shaping ability of new reciprocating or rotary instruments with two cross‐sectional designs: An ex vivo study	41
Intracanal removal and apical extrusion of filling material after retreatment using rotary or reciprocating instruments: A new approach using human cadavers	41
Gut microbiota dysbiosis links chronic apical periodontitis to liver fibrosis in nonalcoholic fatty liver disease: Insights from a mouse model	41
Outcome of full pulpotomy in mature permanent molars using 3 calcium silicate‐based materials: A parallel, double blind, randomized controlled trial	40
Present status and future directions: Managing endodontic emergencies	37
Mitochondrial biogenesis disorder and oxidative damage promote refractory apical periodontitis in rat and human	37
Issue Information	36
Success rate of permanent teeth pulpotomy using bioactive materials: A systematic review and meta‐analysis of randomized clinical trials	36
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Present status and future directions: vertical root fractures in root filled teeth	36
Efficacy of mixture of injectable‐platelet‐rich fibrin and type‐1 collagen particles on the closure of through‐and‐through periapical bone defects: A randomized controlled trial	35
Cannabidiol alleviates LPS‐inhibited odonto/osteogenic differentiation in human dental pulp stem cells in vitro	35
Global cone‐beam computed tomography adoption, usage and scan interpretation preferences of dentists and endodontists	34
The impact of bone grafting with/without barrier membrane placement on the outcome of apical surgery: A systematic review and meta‐analysis	33
Cost‐effectiveness analysis of full versus selective root canal retreatment	33
Type 2 diabetes and the clinically normal pulp: An in vitro study	32
Elevated serum hepatic transaminases in apical periodontitis individuals	31
The presence of Enterococcus in root canal infections based on next‐generation sequencing: A systematic review and meta‐analysis	30
Efficacy of imaging techniques for the diagnosis of apical periodontitis: A systematic review	30
Artificial intelligence chatbots in endodontic education—Concepts and potential applications	30
Issue Information	29
Dental pulp lymphatic vessel dynamics during tooth development and pulp stimulation in rodents	29
Editor‐in‐Chief thanks the Associate Editors, Editorial Board and Referees	28
A critical analysis of clinical research methods to study regenerative endodontics	27
Issue Information	27
Methodological assessment and overall confidence in the results of systematic reviews with network meta‐analyses in Endodontics	26
Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues	26
What does epidemiology tell us about treatment outcomes in endodontics	26
TNFSF13B rs9514828 gene polymorphism and soluble B cell activating factor levels: Association with apical periodontitis	26
Critical analysis of the reporting quality of animal studies within Endodontics using the Preferred Reporting Items for Animal Studies in Endodontics (PRIASE) 2021 quality standard checklist	25
Viability and oxidative stress of dental pulp cells after indirect application of chemomechanical agents: An in vitro study	25
Next‐generation antibacterial nanopolymers for treating oral chronic inflammatory diseases of bacterial origin	25
Benefits of using immersive virtual reality in haptic dental simulation for endodontic access cavity training: A comparative crossover study	24
Prevalence of apical periodontitis and non‐retention of root‐filled teeth in hypertensive patients: Systematic review and meta‐analysis	24
Anaesthetic efficacy of incorporating different additives into lidocaine for the inferior alveolar nerve block: A systematic review with meta‐analysis and trial sequential analysis	24
Effects of phase‐transited lysozyme on adhesion, migration and odontogenic differentiation of human dental pulp cells: An in vitro study	24
Issue Information	23
Letter regarding ‘The global prevalence of apical periodontitis: A systematic review and meta‐analysis’	23
Unveiling the ChatGPT phenomenon: Evaluating the consistency and accuracy of endodontic question answers	23

Nlrp3 inflammasome drives regulatory T cell depletion to accelerate periapical bone erosion	23
A critical review ofin vitroresearch methodologies used to study mineralization in human dental pulp cell cultures	23
Shaping ability of BlueShaper, TruNatomy, DC Taper and HyFlex EDM in long oval canals: An ex vivo study	22
Issue Information	22
Inflammatory and differentiation cellular response to calcium silicate cements: An in vitro study	22
Association between apical periodontitis and secondary outcomes of atherosclerotic cardiovascular disease: A case–control study	22
What is new in the 2023 European Society of Endodontology S3‐level clinical practice guidelines?	22
Comparative analysis of deep dentinal caries microbiota in teeth with normal pulp, reversible pulpitis, symptomatic and asymptomatic irreversible pulpitis	22
Effects of ovariectomy‐induced osteoporosis and two photobiomodulation protocols on the repair of apical periodontitis in Wistar rats: A microCT study	21
The ATF4‐regulated LncRNA MALAT1 promotes odontoblastic differentiation of human dental pulp stem cells via histone demethylase JMJD3: An in vitro study	21
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Tooth survival after endodontic treatment	21
The effect of two different root canal sealers on treatment outcome and post‐obturation pain in single‐visit root canal treatment: A prospective randomized clinical trial	21
Advances in scaffolds used forpulp–dentinecomplex tissue engineering: A narrative review	21
Guanylate‐binding protein 5‐mediated cell‐autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study	21
Exosomes derived from stem cells from the apical papilla alleviate inflammation in rat pulpitis by upregulating regulatory T cells	20
The employment of recommended root canal treatment procedures by dentists in Croatia and the Czech Republic	20
Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model	20
Hsa‐miR‐27b‐5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study	20
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Unveiling the ChatGPT phenomenon: Evaluating the consistency and accuracy of endodontic question answers	19
Outcome of single‐ versus two‐visit root canal retreatment in teeth with periapical lesions: A randomized clinical trial	19
Evaluation of the transdentinal capability of the intrinsic antibacterial cetylpyridinium chloride/cholesterol sterosomes in vitro and in vivo	19
Cytotoxicity, biocompatibility and osteoinductive profile of an MTA‐hydrogel‐based cement: An in vitro and animal study	19
A critical analysis of research methods and experimental models to study biocompatibility of endodontic materials	19
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Association between endodontic, patient‐related factors and severe odontogenic infections; a South Australian retrospective audit	18
Proanthocyanidin surface preconditioning of dental pulp stem cell spheroids enhances dimensional stability and biomineralization in vitro	18
The use of coaching to enhance students' learning, self‐efficacy and performance in endodontics	18
Extracellular vesicles of Candida albicans show dual effects on Enterococcus faecalis growth and virulence: A laboratory‐based investigation	18
Outcome of partial and full pulpotomy in cariously exposed mature molars with symptoms indicative of irreversible pulpitis: A randomized controlled trial	18
Instrumentation kinematics does not affect bacterial reduction, post‐operative pain, and flare‐ups: A randomized clinical trial	18
Abstracts	17
Issue Information	17
Editorial	17
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External cervical resorption – Treatment outcomes and determinants: A retrospective cohort study with up to 10 years of follow‐up	16
The outcome of full and deep pulpotomy in teeth with extremely deep carious lesion and symptomatic irreversible pulpitis: A non‐inferiority randomized controlled trial	16
InternationalEndodonticJournal policy on mandatory prospective (a priori) protocol registration for clinical trials and systematic reviews	16
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Explaining the working mechanism of laser‐activated irrigation and its action on microbial biofilms: A high‐speed imaging study	16
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Growth factor release and dental pulp stem cell attachment following dentine conditioning: An in vitro study	15
The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital permanent teeth with a diagnosis of non‐traumatic pulpitis	15
Intracellular bacterial eradication using a novel peptide in vitro	15
The efficacy of premixed bioceramic sealers versus standard sealers on root canal treatment outcome, extrusion rate and post‐obturation pain: A systematic review and meta‐analysis	15
Calcium hydroxide‐loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament	15
PRIDASE 2024 guidelines for reporting diagnostic accuracy studies in endodontics: A consensus‐based development	15
Inflammatory microenvironment of moderate pulpitis enhances the osteo‐/odontogenic potential of dental pulp stem cells by autophagy	15
Diagnosis consensus among endodontic specialists and general practitioners: An international survey and a proposed modification to the current diagnostic terminology	15
Periapical and endodontic status of patients with inflammatory bowel disease: Age‐ and sex‐matched case–control study	15
Melatonin decreases plasma TNF‐α and improves nonenzymatic antioxidant defence and insulin sensitivity in rats with apical periodontitis fed a high‐fat diet	15
Patient record assessment of results and related resources spent during 1 year after initiation of root canal treatment in a Swedish public dental organization	15
The induction of inflammation by the cGAS–STING pathway in human dental pulp cells: A laboratory investigation	14
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Multimethod analysis of large‐ and low‐tapered single file reciprocating instruments: Design, metallurgy, mechanical performance, and irrigation flow	14
A critical analysis of research methods and experimental models to study tooth discolouration from endodontic materials	14
The expression of cyclic GMP–AMP synthase in human apical periodontitis: A laboratory investigation	14
Case complexity of root canal treatments accepted for training in a secondary care setting assessed by three complexity grading systems: A service evaluation	14
Issue Information	14
Effect of light‐cured pulp capping materials on human dental pulp cells in vitro	14
A critical analysis of research methods and experimental models to study the root canal microbiome	14
Pre‐medical assessment of root–canal–filled teeth with asymptomatic apical periodontitis—A multifaceted balancing act	14
A critical analysis of research methods and experimental models to study apical extrusion of debris and irrigants	14
Patient‐related outcomes and Oral Health‐Related Quality of Life in endodontics	14
Development and preliminary validation of an Objective Structured Assessment of Technical Skills (OSATS) for a partial pulpotomy procedure	14
Characterization of the file‐specific heat‐treated ProTaper Ultimate rotary system	14
Well‐being, postoperative pain and outcome after clinical application of a novel root canal irrigation fluid—RISA—in teeth with apical periodontitis: A first‐in‐human study	14
An international consensus study to identify “what” outcomes should be included in a core outcome set for endodontic treatments (COSET) for utilization in clinical practice and research	13
Osteopontin interacts with dendritic cells and macrophages in pulp inflammation: Comprehensive transcriptomic analysis and laboratory investigations	13
Present status and future directions: The restoration of root filled teeth	13
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Clinical and radiographic outcomes of regenerative endodontic procedures for traumatized permanent necrotic teeth with apical periodontitis and external root resorption	13
From pulp to cementum: 3D visualization of soft and hard dental tissues using different ex vivo nano‐CT contrast‐enhancement techniques	13
In vitro response of dental pulp stem cells to dural substitute grafts: Analysis of cytocompatibility and bioactivity	13
Symptom correlation and spatial distribution of inflammatory mediators in pulpitis—A preliminary study	13
TLR‐2 gene methylation in peripheral blood monocytes from apical periodontitis individuals: A cross‐sectional study	13
Cytocompatibility and bioactive potential of AH Plus Bioceramic Sealer: An in vitro study	13
Characterization of nano‐hydroxyapatite incorporated carboxymethyl chitosan composite on human dental pulp stem cells	13
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Impact of root canal disinfection on the bacteriome present in primary endodontic infection: A next generation sequencing study	12
Sympathetic nerves inhibit dental pulp stem cell differentiation and tertiary dentine formation via α1B‐adrenergic receptor	12
Endodontic position statements in deep caries management highlight need for clarification and consensus for patient benefit	12
Teaching of magnification in the undergraduate curriculum: A position statement from the British Endodontic Society Teachers of Endodontology Group	12
Apical periodontitis as an aggravating factor for the severity of rheumatoid arthritis: An animal study	12
Dentine thickness in maxillary fused molars depends on the fusion type: An ex vivo micro‐computed tomography study	12
Patients with persistent idiopathic dentoalveolar pain in dental practice	12
Issue Information	12
Association between single‐nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment	12
Predictors of societal and professional impact of Endodontology research articles: A multivariate scientometric analysis	12
Advancing insights in contemporary endodontics: Proposing a multimethod approach for comprehensive evaluation of NiTi instruments	12
Multiple cell death modalities and immune response in pulpitis	12
Molecular biomarkers for objective assessment of symptomatic pulpitis: A systematic review and meta‐analysis	11
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Biological evaluation of novel phosphorylated pullulan‐based calcium hydroxide formulations as direct pulp capping materials: An in vivo study on a rat model	11
Post‐operative pain in non‐surgical root canal treatment after sealer‐based obturation versus warm vertical compaction: A randomized clinical trial	11
A video‐based decision aid improved knowledge and decreased decisional conflict for asymptomatic persistent endodontic lesions	11
The detection of apical radiolucencies in periapical radiographs: A comparison between an artificial intelligence platform and expert endodontists with CBCT serving as the diagnostic benchmark	11
Issue Information	11
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Evaluation of postoperative pain and healing following regenerative endodontics using platelet‐rich plasma versus conventional endodontic treatment in necrotic mature mandibular molars with chronic pe	11
Influence of different endodontic treatment protocols on tooth survival: A retrospective cohort study with multistate analysis and group balancing	11
Changes to the ‘Author Guidelines’ for animal and laboratory studies submitted to the International Endodontic Journal	11
Effectiveness of endodontic tissue engineering in treatment of apical periodontitis: A systematic review	11
Hypercitrullination and anti‐citrullinated protein antibodies in chronic apical periodontitis, a laboratory investigation. Does autoimmunity contribute to the pathogenesis?	11
Immunohistochemical evaluation of cyclooxygenase‐2 and mast cell density in periapical lesions	11
Influence of access cavity preparation on the dentine thickness of mesial canals of mandibular molars prepared with reciprocating instruments	10
A comparison of radiographically determined periapical healing and tooth survival outcomes of root canal (re)treatment performed in two care pathways within the United Kingdom Armed Forces	10
XP‐Endo Finisher behaviour and irrigant temperature in intracanal environment: Clinical measurements	10
Comprehensive Comparative Analysis of the Efficiency of Two Clearing Agents in Natural Transparent Teeth Preparation for Dental Education	10
New Editor‐in‐Chief of the International Endodontic Journal	10
Issue Information	10
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Exploring deep caries management and barriers to the use of vital pulp treatments by primary care dental practitioners	10
Experimental borosilicate bioactive glasses: Pulp cells cytocompatibility and mechanical characterization	10
Present status and future directions—Mechanisms and management of local anaesthetic failures	10
The N6‐methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4	10
Issue Information	10
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Axin2‐CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2‐expressing odontogenic cells	10
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Experimental validation of a computational fluid dynamics model using micro‐particle image velocimetry of the irrigation flow in confluent canals	10
Issue Information	10
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Factors that affect the outcomes of root canal treatment and retreatment—A reframing of the principles	10
Characterization and ex vivo modelling of endodontic infections from the Arabian Gulf region	9
What does not form after accidental sodium hypochlorite contact with chlorhexidine?	9
The root canal microbiome diversity and function. A whole‐metagenome shotgun analysis	9
Issue Information	9
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FoxO1 mediates odontoblast differentiation of hDPSCs via B cell‐derived ANGPTL1 in dental caries: A laboratory investigation	9
Chemical and in vivo analyses of calcium silicate‐based materials in bone and connective tissues	9
A comparison of traditional and virtual reality haptic simulator approaches in preclinical endodontic training: Impacts on skill acquisition, confidence and stress	9
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Issue Information	9
Impact of several NiTi‐thermally treated instrumentation systems on biomechanical preparation of curved root canals in extracted mandibular molars	9
Biocompatibility and bioactive potential of NeoPUTTY calcium silicate‐based cement: An in vivo study in rats	9
Calcium hydroxide‐loaded PLGA biodegradable nanoparticles as an intracanal medicament	9
Effectiveness of diagnosing pulpitis: A systematic review	9
The IL‐1β‐p65 axis stimulates quiescent odontogenic epithelial cell rests via TGF‐β signalling to promote cell proliferation of the lining epithelia in radicular cysts: A laborat	9
Editor‐in‐Chief thanks the associate editors, editorial board and referees	8
A critical look at outcome measures: Comparison between four dental research journals by use of a hierarchical model	8
Principle and antimicrobial efficacy of laser‐activated irrigation: A narrative review	8
Discriminatory performance of the pulpal inflammatory biomarkers; Interleukin‐8 and TNF‐α in patients with symptoms indicative of reversible and irreversible pulpitis: A diagnostic accuracy	8
Taxonomic abundance in primary and secondary root canal infections	8
Root filled teeth in two parallel Danish cohorts: A repeated longitudinal cohort study	8
Comparative analysis of methods for measuring root canal curvature based on periapical radiography: A laboratory study	8
Editorial	8
Lipopolysaccharides from Porphyromonas endodontalis and Porphyromonas gingivalis promote angiogenesis via Toll‐like‐receptors 2 and 4 pathways in vitro	8
Nano eggshell‐based slurry as a direct pulp‐capping material: In vitro characterization and histopathological assessment in an experimental animal model	8
Special issue: Next‐generation antimicrobial strategies in endodontics	8
Microbiota associated with caries and apical periodontitis: A next‐generation sequencing study	8
Harnessing antimicrobial peptides in endodontics	8
Treatment of pulpal and apical disease: The European Society of Endodontology (ESE) S3‐level clinical practice guideline	8
New Associate Editor for microbiology and irrigation studies	8
Issue Information	8
Efficacy of Combined Versus Supplementary Injection Techniques With Inferior Alveolar Nerve Block for Mandibular Molars With Symptomatic Irreversible Pulpitis: A Systematic Review and Network Meta‐Ana	8
Issue Information	8
Dorsomorphin attenuates Jagged1‐induced mineralization in human dental pulp cells	8
RGS10 negatively regulates apical periodontitis via TFEB‐mediated autophagy in BABL/c mice model and in vitro	8
Reduced C‐reactive protein levels after root canal treatment in clinically healthy young apical periodontitis individuals at cardiovascular risk. A prospective study	8
The use of 0.5% or 3% NaOCl for irrigation during root canal treatment results in similar clinical outcome: A 6‐year follow‐up of a quasi‐randomized clinical trial	8
Issue Information	8
Treatment outcomes of regenerative endodontic therapy in immature permanent teeth with pulpal necrosis: A systematic review and network meta‐analysis	8
Accuracy of 3‐dimensional surgical guide for endodontic microsurgery with a new design concept: A cadaver study	8
New associate editor for biological studies	8
The impact of blade geometry (nonflat, flat or hybrid) and metallurgical composition on the mechanical performance of NiTi endodontic instruments: A multimethod laboratory study	8
Rev‐erbα attenuates refractory periapical periodontitis via M1 polarization: An in vitro and in vivo study	7
Issue Information	7
MicroRNA‐22 suppresses NLRP3/CASP1 inflammasome pathway‐mediated proinflammatory cytokine production by targeting the HIF‐1α and NLRP3 in human d	7
Endodontic pulp revitalization in traumatized necrotic immature permanent incisors: Early failures and long‐term outcomes—A longitudinal cohort study	7
Abstracts	7
RNA‐sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells	7
Teeth with vital pulps and stage III periodontitis unresponsive to therapy exhibit a pulpal inflammatory profile similar to symptomatic irreversible pulpitis	7