Cell Calcium

Article	Citations
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease	80
Regulating calcium flux through AMPA glutamate receptors	46
Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024)	39
Arriving at the next level of complexity in IP3R and SOCE signaling	39
Store-operated ion channels: A growing family ?	32
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy	31
Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4	29
Rapid quantification of intracellular calcium stores reveals effects of membrane micropeptides on SERCA function	29
TRP channels: Intestinal bloating TRiPs up pathogen avoidance	28
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	28
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	27
Acidic Ca2+ stores and immune-cell function	26
Editorial Board	25
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	24
Relevance of lysosomal Ca2+ signalling machinery in cancer	24
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	23
Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons	22
TRPA1 channel: New kid in the ‘neurovascular coupling’ town	22
The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process	22
MICU1 and MICU2, two peas in a pod or entirely different fruits?	21
How do MICUs gate the mitochondrial calcium uniporter?	21
Calcium signals as regulators of ferroptosis in cancer	21
STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy	21
A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress	21
Dyclonine inhibition of TRPV3: From functional discovery to structural insight	21

Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1	20
Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations”	20
PEG out through the pores with the help of ESCRTIII	20
Opening the floodgates: An emerging role for Connexin-43 hemichannels in the heart	19
Proton-modulated interactions of ions with transport sites of prokaryotic and eukaryotic NCX prototypes	19
STIMulating IRE1: How store-operated Ca2+ entry intersects with ER proteostasis	18
Editorial Board	18
Editorial Board	18
PIP2 primes IP3 receptor activity: It takes at least three IP3s to open!	18
Role of auditory-somatosensory corticothalamic circuit integration in analgesia	18
Editorial Board	16
Remodelling of Ca2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells	16
Minor contribution of NCX to Na+-Ca2+ exchange activity in brain mitochondria	16
Editorial Board	16
High resolution cryo-EM structures of TRPC5-Gαi3 complexes reveal direct activation of an ion channel by Gαi-GTP	16
Glucose-induced [Ca2+]i oscillations in β cells are composed of trains of spikes within a subplasmalemmal microdomain	15
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells	15
IP3 receptors: An “elementary” journey from structure to signals	15
Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking	15
Endolysosomal calcium release and cardiac physiology	15
The tether function of the anoctamins	15
Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer	15
Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome	14
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39	14
Simultaneous TIRF imaging of subplasmalemmal Ca2+ dynamics and granule fusions in insulin-secreting INS-1 cells reveals coexistent synchronized and asynchronous release	14
V for versatility: TRPV4 Ca2+ entry channel plays multiple roles in invadosome regulation	14
Editorial Board	14
Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids	14
Editorial Board	13
The PHATE of basal epidermal cells: Calcium signaling during the cell cycle	13
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome	13
Spicy Science: Structural snapshots of a polymodal nociceptor reveal insights on our sensation to pain, heat, and taste.	13
Pannexin 1 plays a pro-survival role by attenuating P2X7 receptor-mediated Ca2+ influx	12
Editorial Board	12
Editorial Board	12
Regulation of the regulator: Endopeptidase cleavage controls the expression of a micropeptide that regulates SERCA.	12
Killing in the name of: Reversing epigenetic silencing of ITPR3 to succumb cancer cells’ resistance to chemotherapeutics	12
GPCR signalling: Yet another variant route in a highly complex road map	12
Cyclic AMP does double duty to support parallel signaling in primary cilium and cytosol	12
Editorial Board	12
ANO5 in membrane repair - Status: “It’s complicated”	12
Neuronal and astrocyte NCX isoform/splice variants: How do they participate in Na+ and Ca2+ signalling?	11
High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors	11
Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts	11
ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry	11
Calcium signaling and genetic rare diseases: An auditory perspective	11
The evolution of organellar calcium mapping technologies	11
Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on “Structural insights into the regulation of RyR1 by S100A1”	11
Editorial Board	11
STIM1: The lord of the rings?	11

Barriers to exocytotic vesicle discharge	11
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors	10
Channeling hope for uranium-induced kidney damage and beyond with TRPML1	10
Lysosomal potassium channels	10
Scaling up neuronal Ca2+, signaling on ER ladders	10
A KRAP(y) job: Defining the localization of active IP3R	10
Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists	10
Editorial Board	10
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	10
Modulators of TRPM7 and its potential as a drug target for brain tumours	10
Editorial Board	10
Changing of the guards while steering a familiar course	10
Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	10
Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling	9
Distinct pools of synaptic vesicles are released by different calcium channels	9
Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation	9
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	9
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension	9
Calcium and chloride out of sync: The role of signaling in Sjögren's salivary gland issues	9
The multifaceted role of SOCE in central synapses	9
Inhibition of TRPV1 by an antagonist in clinical trials is dependent on cholesterol binding	9
Orai1/STIMs modulators in pulmonary vascular diseases	9
Pan-cancer analysis reveals the prognostic gene CASR suppresses tumor progression and epithelial–mesenchymal transition in renal clear cell carcinoma	9
Calcium signalling in hepatic metabolism: Health and diseases	9
Investigating the landscape of intracellular [Ca2+] in live cells by rapid photoactivated cross-linking of calmodulin-protein interactions	9
Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals	9
SERCA2 phosphorylation at the heart of the disease	9
Role of STIM2 and Orai proteins in regulating TRPC1 channel activity upon calcium store depletion	9
Orai1 is in neurons: Reply to “where have all the Orais gone?”	9
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	9
Endogenous insulin directly protects pancreatic acinar cells in pancreatitis	8
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	8
Uncovering a new route to pain therapy	8
The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth	8
Shocking insights for neurovascular coupling: Electrical signals ignite calcium dynamics in brain capillaries	8
Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX	8
Unravelling the complexity of the mitochondrial Ca2+ uniporter: regulation, tissue specificity, and physiological implications	8
Native SOCE complexes: Small but mighty?	8
“Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE”	8
CatSper channels in sea urchin sperm	8
Coordinated glucose-induced Ca2+ and pH responses in yeast Saccharomyces cerevisiae	7
Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent activation of Transient Receptor Potential Vanilloi	7
Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra	7
Evolutionary diversity of the dual Ca2+ sensor system for neurotransmitter release	7
Emergence of repurposed drugs as modulators of MCU channel for clinical therapeutics	7
Rhomboid pseudoproteases: An Achilles heel's for BCL-2/IP3R-dependent resistance to ER stress-induced cell death	7
Sodium homeostasis and signalling: The core and the hub of astrocyte function	7
The ryanodine receptor microdomain in cardiomyocytes	7
Astrocytic chloride regulates brain function in health and disease	7
Anoctamin 1, a multi-modal player in pain and itch	7
JPT2: The missing link between intracellular Ca2+ release channels and NAADP?	6
VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR	6
Trace metals and astrocytes physiology and pathophysiology	6
Modulation of carbachol-induced Ca2+ oscillations in airway smooth muscle cells by PGE2	6
PI(3,5)P2 and NAADP: Team players or lone warriors? – New insights into TPC activation modes	6
Anoctamin pharmacology	6
Corrigendum to “Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer” [Cell Calcium 102 (2022) 102527]	6
Editorial Board	6
Control of STIM and Orai function by post-translational modifications	6
The STIM1 Phosphorylation Saga	6
A greasy business: Identification of a diacylglycerol binding site in human TRPC5 channels by cryo-EM	6
Recognition of granulocyte-macrophage colony-stimulating factor by specific S100 proteins	6
Excitatory cholinergic responses in mouse primary bronchial smooth muscle require both Ca2+ entry via l-type Ca2+ channels and store operated Ca2+ entry via Orai channels	6
Viewing Ca2+-binding sites in the inositol trisphosphate receptor	6
Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine	6
The unfolding and activation of STIM1 in store-operated calcium signal generation	6
WNK kinase, ion channels and arachidonic acid metabolites choreographically execute endothelium-dependent vasodilation	5
Editorial Board	5
Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer	5
Human IP3 receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism	5
Polarity of action in salivary gland acinar cells: Local and preferential Ca2+ signalling	5
NAADP receptors: A one-two.	5
The role of Ca2+-signaling in the regulation of epigenetic mechanisms	5
TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids	5
How mutations in RYR1 that cause malignant hyperthermia increase RYR1 sensitivity to activators	5
TRPC3, an underestimated, universal pacemaker channel?	5
Enhanced myofilament calcium sensitivity aggravates abnormal calcium handling and diastolic dysfunction in patient-specific induced pluripotent stem cell-derived cardiomyocytes with MYH7 mutation	5
Editorial Board	5
CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer	5
Periphery Pre-S1 and S1 helix nexus for PIP2 at TRPC3 channel	5

Commentary to Baraniak et al. “Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation” published in cell reports 35: 109322.	5
Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures	5
Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores	5
Two-photon calcium imaging of seizures in awake, head-fixed mice	5
Editorial Board	5
AHNAK: The quiet giant in calcium homeostasis	5
Epithelial Anoctamins	4
Exploring the Li+ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX	4
Is CD38 involved in Ca2+ signalling elicited by activation of T cell receptors?	4
Editorial Board	4
The Mitochondrial Ca2+ import complex is altered in ADPKD	4
Genomic approachesidentifySTT4 as a new component in glucose-induced activation of yeast plasma membrane H+-ATPase	4
Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology	4
T-type channels in cancer cells: Driving in reverse	4
Pivotal role of the ORAI3-STIM2 complex in the control of mitotic death and prostate cancer cell cycle progression	4
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses	4
Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration	4
Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells	4
Mitochondria-ER contacts and glucose: the powerhouse of Alzheimer's disease?	4
Editorial Board	4
Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells	4
Editorial Board	4
Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages	4
SERCA-1 conformational change exerted by the Ca2+-channel blocker diltiazem affects mammalian skeletal muscle function	4
Decline of astrocyte Ca2+ signalling in Alzheimer's disease: STIM1 to the rescue!	3
Calcium acts as a critical determinant of mitochondria-nuclear networking driven retrograde signaling	3
Above the legal limit: Alcohol brings ER and mitochondria too close together	3
Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1	3
TREM2 and calcium signaling in microglia – is it relevant for Alzheimer's disease?	3
Nanojunctions: Specificity of Ca2+ signaling requires nano-scale architecture of intracellular membrane contact sites	3
Full-fusion and kiss-and-run in chromaffin cells controlled by irreversible vesicle size-dependent fusion pore transitions	3
RyR-ing up nuclear calcium signaling and CREB-mediated gene expression	3
Anoctamins in epithelial transport	3
The many facets of TMEM63/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond	3
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration	3
CRACing the role of calcium signaling in ILC2s	3
The interplay between associated proteins, redox state and Ca2+ in the intraluminal ER compartment regulates the IP3 receptor	3
Regulation and role of calcium in cellular senescence	3
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?	3
Homeostatic calcium fluxes, ER calcium release, SOCE, and calcium oscillations in cultured astrocytes are interlinked by a small calcium toolkit	3
Roles for TRPV4 in disease: A discussion of possible mechanisms	3
IP3-dependent Ca2+ signals are tightly controlled by Cavβ3, but not by Cavβ1, 2 and 4	3
Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome	3
Two-pore channels (TPCs) acts as a hub for excitation-contraction coupling, metabolism and cardiac hypertrophy signalling	3
Editorial Board	3
Ca2+ transport via TRPV6 is regulated by rapid internalization of the channel	3
Vesicle cholesterol controls exocytotic fusion pore	3
The A-kinase anchoring protein Yotiao decrease the ER calcium content by inhibiting the store operated calcium entry	3
Calcium and redox signals at mitochondrial interfaces: A nanoview perspective	3
Bok joining the “Ca2+ club”	3
Where have all the Orais gone? Commentary on “Orai1 channels are essential for amplification of glutamate-evoked Ca2+ signals in dendritic spines to regulate working and associative memory”	2
Fine tuning calcium dynamics by inhibition of Store-operated Calcium Entry as a novel therapeutic approach for the treatment of chronic pancreatitis	2
A TRPV6 expression atlas for the mouse	2
You better keep an eye on your contacts	2
Orai1/KCa/SigmaR1 complex, the cancer cell suicide squad	2
Spontaneous and action potential-evoked Ca2+ release from endoplasmic reticulum in neocortical synaptic boutons	2
Is Zn2+ the new Ca2+ for TRPC6 channels in the myocardium?	2
Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4,5)P2 split up.	2
Editorial Board	2
A deep learning-based approach for efficient detection and classification of local Ca²⁺ release events in Full-Frame confocal imaging	2
TRPC1: The housekeeper of the hippocampus	2
In vitro and in vivo calibration of low affinity genetic Ca2+ indicators	2
Calcium signaling in lysosome-dependent cell death	2
The role of Ca2+ signalling in the pathology of exocrine pancreas	2
IN BRAIN POST-ISCHEMIC PLASTICITY, Na+/Ca2+ EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE	2
Presynaptic-like mechanisms and the control of insulin secretion in pancreatic β-cells.	2
The quest to map STIM1 activation in granular detail	2
Diversity of two-pore channels and the accessory NAADP receptors in intracellular Ca2+ signaling	2
STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma	2
SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer	2
The role of ion channels in the regulation of dendritic cell function	2
“Gatekeepers of heaven” breaking bad	2
MLKL overexpression leads to Ca2+ and metabolic dyshomeostasis in a neuronal cell model	2
All-optical mapping of Ca2+ transport and homeostasis in dendrites	2
The expression of constitutively active CPK3 impairs potassium uptake and transport in Arabidopsis under low K+ stress	2
Ca2+ signaling and cell death	2
Editorial Board	2
Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms	2
PUFAs dictate the balance of power in ferroptosis	2
Stable expression of SARS-CoV-2 envelope viroporin promotes intracellular calcium depletion in human cells: relevance for endoplasmic reticulum stress, cell proliferation, pluripotency and lineage dif	2
Dimming the donor to brighten up FRET-based biosensors	2
Gating of the capsaicin receptor TRPV1 by UVA-light and oxidants are mediated by distinct mechanisms	2
GPR30 is a potential player between islet cells and ductal HCO3− secretion	2
NAADP signaling: Master manipulation	2
Subcellular localization and transcriptional regulation of brain ryanodine receptors. Functional implications	2