Cell Calcium

Article	Citations
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease	83
Regulating calcium flux through AMPA glutamate receptors	46
Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024)	41
Arriving at the next level of complexity in IP3R and SOCE signaling	37
Store-operated ion channels: A growing family ?	33
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy	32
Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4	31
Acidic Ca2+ stores and immune-cell function	30
TRP channels: Intestinal bloating TRiPs up pathogen avoidance	27
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	27
Rapid quantification of intracellular calcium stores reveals effects of membrane micropeptides on SERCA function	25
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	25
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	24
Editorial Board	24
Relevance of lysosomal Ca2+ signalling machinery in cancer	24
How do MICUs gate the mitochondrial calcium uniporter?	23
The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process	23
Dyclonine inhibition of TRPV3: From functional discovery to structural insight	23
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	23
MICU1 and MICU2, two peas in a pod or entirely different fruits?	22
STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy	22
A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress	22
Calcium signals as regulators of ferroptosis in cancer	21
Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations”	21
Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1	20

STIMulating IRE1: How store-operated Ca2+ entry intersects with ER proteostasis	18
Editorial Board	18
Proton-modulated interactions of ions with transport sites of prokaryotic and eukaryotic NCX prototypes	18
PIP2 primes IP3 receptor activity: It takes at least three IP3s to open!	18
Role of auditory-somatosensory corticothalamic circuit integration in analgesia	17
Editorial Board	16
Editorial Board	16
Macrophage migration inhibitory factor induces phospholamban phosphorylation in cardiac muscle	16
High resolution cryo-EM structures of TRPC5-Gαi3 complexes reveal direct activation of an ion channel by Gαi-GTP	15
IP3 receptors: An “elementary” journey from structure to signals	15
Remodelling of Ca2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells	15
Endolysosomal calcium release and cardiac physiology	15
The role of SERCA in vascular diseases, a potential therapeutic target	15
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells	15
Editorial Board	15
The tether function of the anoctamins	15
Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking	15
Glucose-induced [Ca2+]i oscillations in β cells are composed of trains of spikes within a subplasmalemmal microdomain	15
TRPV1 signaling in skeletal muscle: A mini review of physiological and pathological roles	15
Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer	15
Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome	14
Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids	14
The PHATE of basal epidermal cells: Calcium signaling during the cell cycle	14
Editorial Board	14
Spicy Science: Structural snapshots of a polymodal nociceptor reveal insights on our sensation to pain, heat, and taste.	13
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39	13
Editorial Board	13
GPCR signalling: Yet another variant route in a highly complex road map	13
Simultaneous TIRF imaging of subplasmalemmal Ca2+ dynamics and granule fusions in insulin-secreting INS-1 cells reveals coexistent synchronized and asynchronous release	13
Editorial Board	13
Killing in the name of: Reversing epigenetic silencing of ITPR3 to succumb cancer cells’ resistance to chemotherapeutics	13
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome	13
Editorial Board	13
Editorial Board	13
The evolution of organellar calcium mapping technologies	12
Editorial Board	12
Neuronal and astrocyte NCX isoform/splice variants: How do they participate in Na+ and Ca2+ signalling?	12
Regulation of the regulator: Endopeptidase cleavage controls the expression of a micropeptide that regulates SERCA.	12
Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists	11
Calcium signaling and genetic rare diseases: An auditory perspective	11
Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on “Structural insights into the regulation of RyR1 by S100A1”	11
STIM1: The lord of the rings?	11
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors	11
Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts	11
Barriers to exocytotic vesicle discharge	11
High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors	11
Pannexin 1 plays a pro-survival role by attenuating P2X7 receptor-mediated Ca2+ influx	11
Calcium signalling in hepatic metabolism: Health and diseases	10
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	10
Editorial Board	10

Scaling up neuronal Ca2+, signaling on ER ladders	10
Changing of the guards while steering a familiar course	10
A KRAP(y) job: Defining the localization of active IP3R	10
Editorial Board	10
Channeling hope for uranium-induced kidney damage and beyond with TRPML1	10
ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry	9
Modulators of TRPM7 and its potential as a drug target for brain tumours	9
Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals	9
Investigating the landscape of intracellular [Ca2+] in live cells by rapid photoactivated cross-linking of calmodulin-protein interactions	9
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	9
Calcium and chloride out of sync: The role of signaling in Sjögren's salivary gland issues	9
Pan-cancer analysis reveals the prognostic gene CASR suppresses tumor progression and epithelial–mesenchymal transition in renal clear cell carcinoma	9
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension	9
Lysosomal potassium channels	9
Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	9
Distinct pools of synaptic vesicles are released by different calcium channels	9
Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation	8
Shocking insights for neurovascular coupling: Electrical signals ignite calcium dynamics in brain capillaries	8
Uncovering a new route to pain therapy	8
SERCA2 phosphorylation at the heart of the disease	8
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	8
Endogenous insulin directly protects pancreatic acinar cells in pancreatitis	8
Unravelling the complexity of the mitochondrial Ca2+ uniporter: regulation, tissue specificity, and physiological implications	8
Inhibition of TRPV1 by an antagonist in clinical trials is dependent on cholesterol binding	8
Orai1/STIMs modulators in pulmonary vascular diseases	8
“Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE”	8
The ryanodine receptor microdomain in cardiomyocytes	7
Rhomboid pseudoproteases: An Achilles heel's for BCL-2/IP3R-dependent resistance to ER stress-induced cell death	7
Coordinated glucose-induced Ca2+ and pH responses in yeast Saccharomyces cerevisiae	7
Astrocytic chloride regulates brain function in health and disease	7
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	7
Emergence of repurposed drugs as modulators of MCU channel for clinical therapeutics	7
CatSper channels in sea urchin sperm	7
The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth	7
Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra	6
Trace metals and astrocytes physiology and pathophysiology	6
Recognition of granulocyte-macrophage colony-stimulating factor by specific S100 proteins	6
Excitatory cholinergic responses in mouse primary bronchial smooth muscle require both Ca2+ entry via l-type Ca2+ channels and store operated Ca2+ entry via Orai channels	6
Modulation of carbachol-induced Ca2+ oscillations in airway smooth muscle cells by PGE2	6
Control of STIM and Orai function by post-translational modifications	6
Sodium homeostasis and signalling: The core and the hub of astrocyte function	6
Viewing Ca2+-binding sites in the inositol trisphosphate receptor	6
Editorial Board	6
The STIM1 Phosphorylation Saga	6
Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent activation of Transient Receptor Potential Vanilloi	6
Anoctamin 1, a multi-modal player in pain and itch	6
Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine	6
The unfolding and activation of STIM1 in store-operated calcium signal generation	6
PI(3,5)P2 and NAADP: Team players or lone warriors? – New insights into TPC activation modes	6
VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR	5
Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer	5
Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells	5
Editorial Board	5
TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids	5
TRPC3, an underestimated, universal pacemaker channel?	5
Corrigendum to “Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer” [Cell Calcium 102 (2022) 102527]	5
Editorial Board	5
Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores	5
Editorial Board	5
The role of Ca2+-signaling in the regulation of epigenetic mechanisms	5
WNK kinase, ion channels and arachidonic acid metabolites choreographically execute endothelium-dependent vasodilation	5
Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures	5
Periphery Pre-S1 and S1 helix nexus for PIP2 at TRPC3 channel	5
Enhanced myofilament calcium sensitivity aggravates abnormal calcium handling and diastolic dysfunction in patient-specific induced pluripotent stem cell-derived cardiomyocytes with MYH7 mutation	5
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses	5
CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer	5
Human IP3 receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism	5
Commentary to Baraniak et al. “Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation” published in cell reports 35: 109322.	5
Anoctamin pharmacology	5
Exploring the Li+ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX	4
Is CD38 involved in Ca2+ signalling elicited by activation of T cell receptors?	4
Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration	4
Editorial Board	4
Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells	4
Genomic approachesidentifySTT4 as a new component in glucose-induced activation of yeast plasma membrane H+-ATPase	4
Editorial Board	4
Pivotal role of the ORAI3-STIM2 complex in the control of mitotic death and prostate cancer cell cycle progression	4
Editorial Board	4
Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology	4
SERCA-1 conformational change exerted by the Ca2+-channel blocker diltiazem affects mammalian skeletal muscle function	4

NAADP receptors: A one-two.	4
T-type channels in cancer cells: Driving in reverse	4
Polarity of action in salivary gland acinar cells: Local and preferential Ca2+ signalling	4
The Mitochondrial Ca2+ import complex is altered in ADPKD	4
Editorial Board	4
Editorial Board	3
The interplay between associated proteins, redox state and Ca2+ in the intraluminal ER compartment regulates the IP3 receptor	3
The A-kinase anchoring protein Yotiao decrease the ER calcium content by inhibiting the store operated calcium entry	3
The many facets of TMEM63/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond	3
IP3-dependent Ca2+ signals are tightly controlled by Cavβ3, but not by Cavβ1, 2 and 4	3
Calcium and redox signals at mitochondrial interfaces: A nanoview perspective	3
Full-fusion and kiss-and-run in chromaffin cells controlled by irreversible vesicle size-dependent fusion pore transitions	3
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?	3
Anoctamins in epithelial transport	3
Calcium acts as a critical determinant of mitochondria-nuclear networking driven retrograde signaling	3
Two-pore channels (TPCs) acts as a hub for excitation-contraction coupling, metabolism and cardiac hypertrophy signalling	3
Bok joining the “Ca2+ club”	3
Above the legal limit: Alcohol brings ER and mitochondria too close together	3
CRACing the role of calcium signaling in ILC2s	3
RyR-ing up nuclear calcium signaling and CREB-mediated gene expression	3
Epithelial Anoctamins	3
Decline of astrocyte Ca2+ signalling in Alzheimer's disease: STIM1 to the rescue!	3
Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome	3
NAADP signaling: Master manipulation	2
The quest to map STIM1 activation in granular detail	2
Stable expression of SARS-CoV-2 envelope viroporin promotes intracellular calcium depletion in human cells: relevance for endoplasmic reticulum stress, cell proliferation, pluripotency and lineage dif	2
Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4,5)P2 split up.	2
You better keep an eye on your contacts	2
In vitro and in vivo calibration of low affinity genetic Ca2+ indicators	2
IN BRAIN POST-ISCHEMIC PLASTICITY, Na+/Ca2+ EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE	2
All-optical mapping of Ca2+ transport and homeostasis in dendrites	2
Editorial Board	2
The expression of constitutively active CPK3 impairs potassium uptake and transport in Arabidopsis under low K+ stress	2
Ca2+ transport via TRPV6 is regulated by rapid internalization of the channel	2
Vesicle cholesterol controls exocytotic fusion pore	2
MLKL overexpression leads to Ca2+ and metabolic dyshomeostasis in a neuronal cell model	2
“Gatekeepers of heaven” breaking bad	2
Diversity of two-pore channels and the accessory NAADP receptors in intracellular Ca2+ signaling	2
STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma	2
GPR30 is a potential player between islet cells and ductal HCO3− secretion	2
A deep learning-based approach for efficient detection and classification of local Ca²⁺ release events in Full-Frame confocal imaging	2
A TRPV6 expression atlas for the mouse	2
TRPC1: The housekeeper of the hippocampus	2
Nanojunctions: Specificity of Ca2+ signaling requires nano-scale architecture of intracellular membrane contact sites	2
Fine tuning calcium dynamics by inhibition of Store-operated Calcium Entry as a novel therapeutic approach for the treatment of chronic pancreatitis	2
TREM2 and calcium signaling in microglia – is it relevant for Alzheimer's disease?	2
Roles for TRPV4 in disease: A discussion of possible mechanisms	2
Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1	2
Editorial Board	2
Is Zn2+ the new Ca2+ for TRPC6 channels in the myocardium?	2
Dimming the donor to brighten up FRET-based biosensors	2
The role of ion channels in the regulation of dendritic cell function	2
Subcellular localization and transcriptional regulation of brain ryanodine receptors. Functional implications	2
Campari2 genomic interrogation of homeostatic calcium activity identifies TIM1 as a negative regulator of T cell function	2
Calcium signaling in lysosome-dependent cell death	2
Ca2+ signaling and cell death	2
The role of Ca2+ signalling in the pathology of exocrine pancreas	2
Homeostatic calcium fluxes, ER calcium release, SOCE, and calcium oscillations in cultured astrocytes are interlinked by a small calcium toolkit	2
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration	2
Regulation and role of calcium in cellular senescence	2