Cell Calcium

Article	Citations
Regulating calcium flux through AMPA glutamate receptors	56
Arriving at the next level of complexity in IP3R and SOCE signaling	47
Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024)	47
Store-operated ion channels: A growing family ?	45
Protein diversity in store-operated calcium entry components and their related variants	39
Acidic Ca2+ stores and immune-cell function	37
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	34
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy	32
Rapid quantification of intracellular calcium stores reveals effects of membrane micropeptides on SERCA function	31
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease	30
Editorial Board	29
ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets	29
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	29
The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process	28
Abnormal calcium activity and CREB phosphorylation are associated with motor memory impairment in presenilin-1 mutant knock-in mice	27
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	27
MICU1 and MICU2, two peas in a pod or entirely different fruits?	26
STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy	26
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	25
Relevance of lysosomal Ca2+ signalling machinery in cancer	25
A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress	23
Dyclonine inhibition of TRPV3: From functional discovery to structural insight	23
Calcium signals as regulators of ferroptosis in cancer	22
Macrophage migration inhibitory factor induces phospholamban phosphorylation in cardiac muscle	21
Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations”	20

STIMulating IRE1: How store-operated Ca2+ entry intersects with ER proteostasis	20
Editorial Board	19
Histamine 1 receptors and reverse-mode Na+/Ca2+ exchanger drive extracellular Na+-dependent intracellular Ca2+ oscillations in human cerebrovascular endothelial cells	19
PIP2 primes IP3 receptor activity: It takes at least three IP3s to open!	19
Role of auditory-somatosensory corticothalamic circuit integration in analgesia	19
Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1	18
Editorial Board	18
Endolysosomal calcium release and cardiac physiology	18
Neuronal regulation of myenteric interstitial cells of Cajal (ICC-MY) in the proximal colon	18
Ca2+/calmodulin-driven functions mediated by extracellular vesicles: a physiopathological perspective	18
NAADP-mediated calcium release promotes angiopoietin 2 secretion by regulating Rab46-dependent Weibel-Palade body trafficking	18
TRPV1 signaling in skeletal muscle: A mini review of physiological and pathological roles	18
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells	18
Editorial Board	18
Editorial Board	18
High resolution cryo-EM structures of TRPC5-Gαi3 complexes reveal direct activation of an ion channel by Gαi-GTP	18
The PHATE of basal epidermal cells: Calcium signaling during the cell cycle	17
Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer	17
Editorial Board	17
The role of SERCA in vascular diseases, a potential therapeutic target	17
The tether function of the anoctamins	17
IP3 receptors: An “elementary” journey from structure to signals	17
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39	16
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome	16
Editorial Board	16
Editorial Board	16
Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids	16
GPCR signalling: Yet another variant route in a highly complex road map	16
Spicy Science: Structural snapshots of a polymodal nociceptor reveal insights on our sensation to pain, heat, and taste.	16
Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome	15
Killing in the name of: Reversing epigenetic silencing of ITPR3 to succumb cancer cells’ resistance to chemotherapeutics	14
Editorial Board	14
Editorial Board	14
Simultaneous TIRF imaging of subplasmalemmal Ca2+ dynamics and granule fusions in insulin-secreting INS-1 cells reveals coexistent synchronized and asynchronous release	14
Editorial Board	14
Regulation of the regulator: Endopeptidase cleavage controls the expression of a micropeptide that regulates SERCA.	14
CPVT1 point mutations in RyR2 S5 and S6 segments and their Ca2+ signaling consequence	13
The evolution of organellar calcium mapping technologies	13
Neuronal and astrocyte NCX isoform/splice variants: How do they participate in Na+ and Ca2+ signalling?	12
Barriers to exocytotic vesicle discharge	12
High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors	12
Calcium signaling and genetic rare diseases: An auditory perspective	12
STIM1: The lord of the rings?	11
Editorial Board	11
Regulation of K+-dependent Na+/Ca2+-exchanger subtype 4, NCKX4, by palmitoylation	11
Channeling hope for uranium-induced kidney damage and beyond with TRPML1	11
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	11
Changing of the guards while steering a familiar course	11
Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on “Structural insights into the regulation of RyR1 by S100A1”	11
Scaling up neuronal Ca2+, signaling on ER ladders	11

Transglutaminase 2 controls calcium dependent mitochondrial dysfunction and fibroblast senescence by repressing PIEZO2	10
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	10
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension	10
Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists	10
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors	10
Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	10
Lysosomal potassium channels	10
Calcium and chloride out of sync: The role of signaling in Sjögren's salivary gland issues	9
Ablation of mitochondrial calcium uniporter alleviates cardiac dysfunction in type 1 diabetes	9
Distinct pools of synaptic vesicles are released by different calcium channels	9
Copine A is essential for calcium homeostasis in Dictyostelium	9
Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals	9
Modulators of TRPM7 and its potential as a drug target for brain tumours	9
Calcium signalling in hepatic metabolism: Health and diseases	9
Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation	9
SERCA2 phosphorylation at the heart of the disease	9
Inhibition of TRPV1 by an antagonist in clinical trials is dependent on cholesterol binding	9
ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry	9
Connexin 43 as a novel Ca2+ transport pathway in the nuclear envelope of human induced pluripotent stem cell derived cardiomyocytes	9
Orai1/STIMs modulators in pulmonary vascular diseases	9
Pan-cancer analysis reveals the prognostic gene CASR suppresses tumor progression and epithelial–mesenchymal transition in renal clear cell carcinoma	9
LETM1 and mitochondrial calcium homeostasis: A controversial but critical role in cellular function and disease	8
“Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE”	8
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	8
Editorial Board	8
Shocking insights for neurovascular coupling: Electrical signals ignite calcium dynamics in brain capillaries	8
CNO induced Ca2+ store and glutamate-dependent nonspecific Ca2+ signalling in DREADD-free brain slices	8
The ryanodine receptor microdomain in cardiomyocytes	8
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	8
Uncovering a new route to pain therapy	8
Unravelling the complexity of the mitochondrial Ca2+ uniporter: regulation, tissue specificity, and physiological implications	8
The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth	8
Sodium homeostasis and signalling: The core and the hub of astrocyte function	7
Rhomboid pseudoproteases: An Achilles heel's for BCL-2/IP3R-dependent resistance to ER stress-induced cell death	7
Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent activation of Transient Receptor Potential Vanilloi	7
Trace metals and astrocytes physiology and pathophysiology	7
Astrocytic chloride regulates brain function in health and disease	7
Emerging therapeutics targeting the PI3K/Akt/GSK-3β in calcium dysregulation in Alzheimer’s disease	6
Editorial Board	6
Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine	6
Anoctamin pharmacology	6
Recognition of granulocyte-macrophage colony-stimulating factor by specific S100 proteins	6
Anoctamin 1, a multi-modal player in pain and itch	6
Viewing Ca2+-binding sites in the inositol trisphosphate receptor	6
The unfolding and activation of STIM1 in store-operated calcium signal generation	6
PI(3,5)P2 and NAADP: Team players or lone warriors? – New insights into TPC activation modes	6
Excitatory cholinergic responses in mouse primary bronchial smooth muscle require both Ca2+ entry via l-type Ca2+ channels and store operated Ca2+ entry via Orai channels	6
Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra	6
Modulation of carbachol-induced Ca2+ oscillations in airway smooth muscle cells by PGE2	6
The handshake between the continuous remodeling of the endoplasmic reticulum and the store-operated calcium entry	6
The STIM1 Phosphorylation Saga	6
Control of STIM and Orai function by post-translational modifications	6
TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids	5
Pathological calcium influx through amyloid beta pores disrupts synaptic function	5
Editorial Board	5
Exploring the Li+ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX	5
VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR	5
Editorial Board	5
Human IP3 receptor triple knockout stem cells remain pluripotent despite altered mitochondrial metabolism	5
Enhanced myofilament calcium sensitivity aggravates abnormal calcium handling and diastolic dysfunction in patient-specific induced pluripotent stem cell-derived cardiomyocytes with MYH7 mutation	5
The role of Ca2+-signaling in the regulation of epigenetic mechanisms	5
Editorial Board	5
Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer	5
Corrigendum to “Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer” [Cell Calcium 102 (2022) 102527]	5
WNK kinase, ion channels and arachidonic acid metabolites choreographically execute endothelium-dependent vasodilation	5
CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer	5
Editorial Board	5
Is CD38 involved in Ca2+ signalling elicited by activation of T cell receptors?	5
Periphery Pre-S1 and S1 helix nexus for PIP2 at TRPC3 channel	5
Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores	5
Nuclear Ca2+-Calmodulin signaling in cardiac myocytes reduces catecholamine-evoked protein translation and prevents hypertrophy	5
Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells	4
Fura-10, unlike fura-2, is suitable for long-term calcium imaging in natural killer (NK) cells without compromising cytotoxicity and can be combined with target cell death analysis	4
Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology	4
Editorial Board	4
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses	4
Genomic approachesidentifySTT4 as a new component in glucose-induced activation of yeast plasma membrane H+-ATPase	4
Two-pore channels (TPCs) acts as a hub for excitation-contraction coupling, metabolism and cardiac hypertrophy signalling	4
Epithelial Anoctamins	4
T-type channels in cancer cells: Driving in reverse	4

Pivotal role of the ORAI3-STIM2 complex in the control of mitotic death and prostate cancer cell cycle progression	4
Editorial Board	4
Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome	3
The Mitochondrial Ca2+ import complex is altered in ADPKD	3
The interplay between associated proteins, redox state and Ca2+ in the intraluminal ER compartment regulates the IP3 receptor	3
Full-fusion and kiss-and-run in chromaffin cells controlled by irreversible vesicle size-dependent fusion pore transitions	3
Editorial Board	3
Decline of astrocyte Ca2+ signalling in Alzheimer's disease: STIM1 to the rescue!	3
The many facets of TMEM63/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond	3
Calcium and redox signals at mitochondrial interfaces: A nanoview perspective	3
Vesicle cholesterol controls exocytotic fusion pore	3
Calcium acts as a critical determinant of mitochondria-nuclear networking driven retrograde signaling	3
IP3-dependent Ca2+ signals are tightly controlled by Cavβ3, but not by Cavβ1, 2 and 4	3
Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells	3
Above the legal limit: Alcohol brings ER and mitochondria too close together	3
CRACing the role of calcium signaling in ILC2s	3
Editorial Board	3
SERCA-1 conformational change exerted by the Ca2+-channel blocker diltiazem affects mammalian skeletal muscle function	3
Nanojunctions: Specificity of Ca2+ signaling requires nano-scale architecture of intracellular membrane contact sites	2
Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1	2
Roles for TRPV4 in disease: A discussion of possible mechanisms	2
Homeostatic calcium fluxes, ER calcium release, SOCE, and calcium oscillations in cultured astrocytes are interlinked by a small calcium toolkit	2
The A-kinase anchoring protein Yotiao decrease the ER calcium content by inhibiting the store operated calcium entry	2
Campari2 genomic interrogation of homeostatic calcium activity identifies TIM1 as a negative regulator of T cell function	2
IN BRAIN POST-ISCHEMIC PLASTICITY, Na+/Ca2+ EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE	2
Endothelial PIEZO1 activation impairs osteogenesis via GREM1-mediated inhibition of BMP signaling	2
Subcellular localization and transcriptional regulation of brain ryanodine receptors. Functional implications	2
NAADP signaling: Master manipulation	2
TREM2 and calcium signaling in microglia – is it relevant for Alzheimer's disease?	2
Ca2+ transport via TRPV6 is regulated by rapid internalization of the channel	2
The role of Ca2+ signalling in the pathology of exocrine pancreas	2
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration	2
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?	2
Editorial Board	2
TRPC1: The housekeeper of the hippocampus	2
“Gatekeepers of heaven” breaking bad	2
A deep learning-based approach for efficient detection and classification of local Ca²⁺ release events in Full-Frame confocal imaging	2
MLKL overexpression leads to Ca2+ and metabolic dyshomeostasis in a neuronal cell model	2
Fine tuning calcium dynamics by inhibition of Store-operated Calcium Entry as a novel therapeutic approach for the treatment of chronic pancreatitis	2
All-optical mapping of Ca2+ transport and homeostasis in dendrites	2
Regulation and role of calcium in cellular senescence	2
Anoctamins in epithelial transport	2
Calcium signaling in lysosome-dependent cell death	2
You better keep an eye on your contacts	2
Orai1 plays a critical role in Orai3 synthesis and stability in luminal breast cancer cells	2
In vitro and in vivo calibration of low affinity genetic Ca2+ indicators	2
Ca2+ signaling and cell death	2