OOIR: Observatory of International Research

Papers

(The TQCC of Cell Calcium is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels	75
Mitochondria Associated Membranes (MAMs): Architecture and physiopathological role	69
Role of mitochondria in liver metabolic health and diseases	60
Structural insights into the gating mechanisms of TRPV channels	54
VDAC regulation of mitochondrial calcium flux: From channel biophysics to disease	51
Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration	51
Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury	47
Mitochondrial reactive oxygen species in physiology and disease	42
The aging mouse brain: cognition, connectivity and calcium	41
Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway	39
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel	37
Role of ion channels during cell division	34
The Na+/Ca2+exchanger in Alzheimer’s disease	33
A trio has turned into a quartet: DJ-1 interacts with the IP3R-Grp75-VDAC complex to control ER-mitochondria interaction	33
Mechanosensitive Piezo1 in endothelial cells promotes angiogenesis to support bone fracture repair	32
IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi	31
Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?	30
Reliable measurement of free Ca2+ concentrations in the ER lumen using Mag-Fluo-4	30
The molecular complexity of the Mitochondrial Calcium Uniporter	29
Heterogeneous expression of plasma-membrane-localised OsOSCA1.4 complements osmotic sensing based on hyperosmolality and salt stress in Arabidopsis osca1 mutant	28
BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca2+-dependent mPTP opening	27
α-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transport	27
Role of TRPM7 kinase in cancer	24
Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2	24
Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models	23

Targeting mitochondrial calcium pathways as a potential treatment against Parkinson’s disease	23
Ca2+ as the prime trigger of aerobic glycolysis in astrocytes	22
Calsequestrin. Structure, function, and evolution	21
Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4	21
Skeletal muscle mitochondria in health and disease	21
Orai3: Oncochannel with therapeutic potential	20
Two-photon calcium imaging of seizures in awake, head-fixed mice	20
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells	20
The role of potassium and host calcium signaling in Toxoplasma gondii egress	20
Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent activation of Transient Receptor Potential Vanilloi	20
SEPT7 regulates Ca2+ entry through Orai channels in human neural progenitor cells and neurons	20
The calcium signaling enzyme CD38 - a paradigm for membrane topology defining distinct protein functions	19
TRPM7 activation potentiates SOCE in enamel cells but requires ORAI	18
Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid	18
The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells	18
Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo	17
Calcium signaling and epigenetics: A key point to understand carcinogenesis	17
AHNAK: The quiet giant in calcium homeostasis	16
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	16
Modulating TRPV4 channels with paclitaxel and lithium	16
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties	16
Insights and perspectives on calcium channel functions in the cockpit of cancerous space invaders	15
Recent studies on NCLX in health and diseases	15
Multiple facets of TRPML1 in autophagy	15
Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking	15
Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells	15
Control of STIM and Orai function by post-translational modifications	15
GCaMP as an indirect measure of electrical activity in rat trigeminal ganglion neurons	15
Transcriptional and epigenetic regulation of ncx1 and ncx3 in the brain	15
Visible light excited ratiometric-GECIs for long-term in-cellulo monitoring of calcium signals	14
Regulation and role of calcium in cellular senescence	14
ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway	14
The great astroglial metabolic revolution: Mitochondria fuel astrocyte homeostatic support and neuroprotection	14
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?	14
Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling	14
Vesicle cholesterol controls exocytotic fusion pore	14
A high throughput machine-learning driven analysis of Ca2+ spatio-temporal maps	14
Metabolite regulation of the mitochondrial calcium uniporter channel	13
Enhanced modulation of cell-type specific neuronal responses in mouse dorsal auditory field during locomotion	13
Attenuation of the extracellular matrix increases the number of synapses but suppresses synaptic plasticity through upregulation of SK channels	13
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	13
The yin and yang of mitochondrial Ca2+ signaling in cell physiology and pathology	13
Inhibition of TRPM7 with waixenicin A reduces glioblastoma cellular functions	13
Distinct properties of Ca2+ efflux from brain, heart and liver mitochondria: The effects of Na+, Li+ and the mitochondrial Na+/Ca2+ exchange inhibitor CGP37157	13
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	13
PIP2 and septin control STIM1/Orai1 assembly by regulating cytoskeletal remodeling via a CDC42-WASP/WAVE-ARP2/3 protein complex	13
Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies	13
The basics of mitochondrial cAMP signalling: Where, when, why	13
NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model	13
Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1	12

A novel role of FKN/CX3CR1 in promoting osteogenic transformation of VSMCs and atherosclerotic calcification	12
The mitochondrial permeability transition pore in Ca2+ homeostasis	12
Ca2+ signaling of human pluripotent stem cells-derived cardiomyocytes as compared to adult mammalian cardiomyocytes	12
BRAF and NRAS mutated melanoma: Different Ca2+ responses, Na+/Ca2+ exchanger expression, and sensitivity to inhibitors	12
Acidic Ca2+ stores and immune-cell function	12
The ER-mitochondria interface, where Ca2+ and cell death meet	11
Mending Fences: Na,K-ATPase signaling via Ca2+ in the maintenance of epithelium integrity	11
Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications	11
New perspectives for selective NCX activators in neurodegenerative diseases	11
Calcium signaling: A therapeutic target to overcome resistance to therapies in cancer	11
Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know.	11
Divalent cation influx and calcium homeostasis in germinal vesicle mouse oocytes	11
Cracking the code of sodium/calcium exchanger (NCX) gating: Old and new complexities surfacing from the deep web of secondary regulations	11
Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin	11
Specific cytokines of interleukin-6 family interact with S100 proteins	11
SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer	10
Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX	10
Na+/Ca2+ exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons	10
PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection	10
PUFAs dictate the balance of power in ferroptosis	10
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	10
TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells	10
Multi-scale network imaging in a mouse model of amyloidosis	9
The impact of calmodulin on the cell cycle analyzed in a novel human cellular genetic system	9
Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4	9
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39	9
Ca2+ signaling in postsynaptic neurons: Neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors	9
Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling	9
Nuclear-encoded NCX3 and AKAP121: Two novel modulators of mitochondrial calcium efflux in normoxic and hypoxic neurons	9
TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01	9
Differential modulation of SK channel subtypes by phosphorylation	9
Role of STIM2 and Orai proteins in regulating TRPC1 channel activity upon calcium store depletion	9
Lysosomal potassium channels	9
Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores	9
Ca2+ signaling and cell death	8
Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume	8
Remodelling of Ca2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells	8
In vivo analysis of the spontaneous firing of cerebellar Purkinje cells in awake transgenic mice that model spinocerebellar ataxia type 2	8
The ins and outs of virus trafficking through acidic Ca2+ stores	8
Modulators of TRPM7 and its potential as a drug target for brain tumours	8
Multipurpose Na+ ions mediate excitation and cellular homeostasis: Evolution of the concept of Na+ pumps and Na+/Ca2+ exchangers	8
Glucose-induced [Ca2+]i oscillations in β cells are composed of trains of spikes within a subplasmalemmal microdomain	8
CatSper channels in sea urchin sperm	8
Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice	8
Sodium/calcium exchanger as main effector of endogenous neuroprotection elicited by ischemic tolerance	8
Relevance of lysosomal Ca2+ signalling machinery in cancer	8
Pannexin 1 plays a pro-survival role by attenuating P2X7 receptor-mediated Ca2+ influx	8
Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal	8
The TAM-associated STIM1I484R mutation increases ORAI1 channel function due to a reduced STIM1 inactivation break and an absence of microtubule trapping	8
Homeostatic calcium fluxes, ER calcium release, SOCE, and calcium oscillations in cultured astrocytes are interlinked by a small calcium toolkit	8
CaMKIV regulates mitochondrial dynamics during sepsis	8
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	8