OOIR: Observatory of International Research

Papers

(The TQCC of Cell Calcium is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Regulating calcium flux through AMPA glutamate receptors	56
Arriving at the next level of complexity in IP3R and SOCE signaling	47
Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024)	47
Store-operated ion channels: A growing family ?	45
Protein diversity in store-operated calcium entry components and their related variants	39
Acidic Ca2+ stores and immune-cell function	37
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	34
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy	32
Rapid quantification of intracellular calcium stores reveals effects of membrane micropeptides on SERCA function	31
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease	30
ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets	29
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	29
Editorial Board	29
The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process	28
Abnormal calcium activity and CREB phosphorylation are associated with motor memory impairment in presenilin-1 mutant knock-in mice	27
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	27
MICU1 and MICU2, two peas in a pod or entirely different fruits?	26
STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy	26
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	25
Relevance of lysosomal Ca2+ signalling machinery in cancer	25
A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress	23
Dyclonine inhibition of TRPV3: From functional discovery to structural insight	23
Calcium signals as regulators of ferroptosis in cancer	22
Macrophage migration inhibitory factor induces phospholamban phosphorylation in cardiac muscle	21
Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations”	20

STIMulating IRE1: How store-operated Ca2+ entry intersects with ER proteostasis	20
Editorial Board	19
Histamine 1 receptors and reverse-mode Na+/Ca2+ exchanger drive extracellular Na+-dependent intracellular Ca2+ oscillations in human cerebrovascular endothelial cells	19
PIP2 primes IP3 receptor activity: It takes at least three IP3s to open!	19
Role of auditory-somatosensory corticothalamic circuit integration in analgesia	19
Editorial Board	18
Endolysosomal calcium release and cardiac physiology	18
Neuronal regulation of myenteric interstitial cells of Cajal (ICC-MY) in the proximal colon	18
Ca2+/calmodulin-driven functions mediated by extracellular vesicles: a physiopathological perspective	18
NAADP-mediated calcium release promotes angiopoietin 2 secretion by regulating Rab46-dependent Weibel-Palade body trafficking	18
TRPV1 signaling in skeletal muscle: A mini review of physiological and pathological roles	18
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells	18
Editorial Board	18
Editorial Board	18
High resolution cryo-EM structures of TRPC5-Gαi3 complexes reveal direct activation of an ion channel by Gαi-GTP	18
Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1	18
Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer	17
Editorial Board	17
The role of SERCA in vascular diseases, a potential therapeutic target	17
The tether function of the anoctamins	17
IP3 receptors: An “elementary” journey from structure to signals	17
The PHATE of basal epidermal cells: Calcium signaling during the cell cycle	17
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39	16
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome	16
Editorial Board	16
Editorial Board	16
Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids	16
GPCR signalling: Yet another variant route in a highly complex road map	16
Spicy Science: Structural snapshots of a polymodal nociceptor reveal insights on our sensation to pain, heat, and taste.	16
Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome	15
Killing in the name of: Reversing epigenetic silencing of ITPR3 to succumb cancer cells’ resistance to chemotherapeutics	14
Editorial Board	14
Editorial Board	14
Simultaneous TIRF imaging of subplasmalemmal Ca2+ dynamics and granule fusions in insulin-secreting INS-1 cells reveals coexistent synchronized and asynchronous release	14
Editorial Board	14
Regulation of the regulator: Endopeptidase cleavage controls the expression of a micropeptide that regulates SERCA.	14
CPVT1 point mutations in RyR2 S5 and S6 segments and their Ca2+ signaling consequence	13
The evolution of organellar calcium mapping technologies	13
Neuronal and astrocyte NCX isoform/splice variants: How do they participate in Na+ and Ca2+ signalling?	12
Barriers to exocytotic vesicle discharge	12
High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors	12
Calcium signaling and genetic rare diseases: An auditory perspective	12
Regulation of K+-dependent Na+/Ca2+-exchanger subtype 4, NCKX4, by palmitoylation	11
Channeling hope for uranium-induced kidney damage and beyond with TRPML1	11
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	11
Changing of the guards while steering a familiar course	11
Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on “Structural insights into the regulation of RyR1 by S100A1”	11
Scaling up neuronal Ca2+, signaling on ER ladders	11
STIM1: The lord of the rings?	11
Editorial Board	11

Transglutaminase 2 controls calcium dependent mitochondrial dysfunction and fibroblast senescence by repressing PIEZO2	10
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	10
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension	10
Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists	10
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors	10
Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	10
Lysosomal potassium channels	10
Calcium and chloride out of sync: The role of signaling in Sjögren's salivary gland issues	9
Ablation of mitochondrial calcium uniporter alleviates cardiac dysfunction in type 1 diabetes	9
Distinct pools of synaptic vesicles are released by different calcium channels	9
Copine A is essential for calcium homeostasis in Dictyostelium	9
Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals	9
Modulators of TRPM7 and its potential as a drug target for brain tumours	9
Calcium signalling in hepatic metabolism: Health and diseases	9
SERCA2 phosphorylation at the heart of the disease	9
Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation	9
Inhibition of TRPV1 by an antagonist in clinical trials is dependent on cholesterol binding	9
ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry	9
Connexin 43 as a novel Ca2+ transport pathway in the nuclear envelope of human induced pluripotent stem cell derived cardiomyocytes	9
Orai1/STIMs modulators in pulmonary vascular diseases	9
Pan-cancer analysis reveals the prognostic gene CASR suppresses tumor progression and epithelial–mesenchymal transition in renal clear cell carcinoma	9
LETM1 and mitochondrial calcium homeostasis: A controversial but critical role in cellular function and disease	8
“Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE”	8
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	8
Editorial Board	8
Shocking insights for neurovascular coupling: Electrical signals ignite calcium dynamics in brain capillaries	8
CNO induced Ca2+ store and glutamate-dependent nonspecific Ca2+ signalling in DREADD-free brain slices	8
The ryanodine receptor microdomain in cardiomyocytes	8
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	8
Uncovering a new route to pain therapy	8
Unravelling the complexity of the mitochondrial Ca2+ uniporter: regulation, tissue specificity, and physiological implications	8
The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth	8