OOIR: Observatory of International Research

Papers

(The TQCC of Cell Calcium is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease	80
Regulating calcium flux through AMPA glutamate receptors	46
Arriving at the next level of complexity in IP3R and SOCE signaling	39
Commentary on: Li et al.; Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds. Nature Communications (2024)	39
Store-operated ion channels: A growing family ?	32
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy	31
Rapid quantification of intracellular calcium stores reveals effects of membrane micropeptides on SERCA function	29
Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4	29
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics	28
TRP channels: Intestinal bloating TRiPs up pathogen avoidance	28
ZnT1 is a neuronal Zn2+/Ca2+ exchanger	27
Acidic Ca2+ stores and immune-cell function	26
Editorial Board	25
Relevance of lysosomal Ca2+ signalling machinery in cancer	24
Characterization of a functional Ca2+ toolkit in urine-derived stem cells and derived skeletal muscle cells	24
TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors	23
The IP3 receptor-KRAP complex at the desmosomes: A new player in the apoptotic process	22
Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons	22
TRPA1 channel: New kid in the ‘neurovascular coupling’ town	22
A role for lysosomal calcium channels in mitigating mitochondrial damage and oxidative stress	21
Dyclonine inhibition of TRPV3: From functional discovery to structural insight	21
MICU1 and MICU2, two peas in a pod or entirely different fruits?	21
How do MICUs gate the mitochondrial calcium uniporter?	21
Calcium signals as regulators of ferroptosis in cancer	21
STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy	21

PEG out through the pores with the help of ESCRTIII	20
Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1	20
Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations”	20
Proton-modulated interactions of ions with transport sites of prokaryotic and eukaryotic NCX prototypes	19
Opening the floodgates: An emerging role for Connexin-43 hemichannels in the heart	19
Role of auditory-somatosensory corticothalamic circuit integration in analgesia	18
STIMulating IRE1: How store-operated Ca2+ entry intersects with ER proteostasis	18
Editorial Board	18
Editorial Board	18
PIP2 primes IP3 receptor activity: It takes at least three IP3s to open!	18
Minor contribution of NCX to Na+-Ca2+ exchange activity in brain mitochondria	16
Editorial Board	16
High resolution cryo-EM structures of TRPC5-Gαi3 complexes reveal direct activation of an ion channel by Gαi-GTP	16
Editorial Board	16
Remodelling of Ca2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells	16
Endolysosomal calcium release and cardiac physiology	15
The tether function of the anoctamins	15
Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer	15
Glucose-induced [Ca2+]i oscillations in β cells are composed of trains of spikes within a subplasmalemmal microdomain	15
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells	15
IP3 receptors: An “elementary” journey from structure to signals	15
Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking	15
Editorial Board	14
Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids	14
Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome	14
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39	14
Simultaneous TIRF imaging of subplasmalemmal Ca2+ dynamics and granule fusions in insulin-secreting INS-1 cells reveals coexistent synchronized and asynchronous release	14
V for versatility: TRPV4 Ca2+ entry channel plays multiple roles in invadosome regulation	14
Spicy Science: Structural snapshots of a polymodal nociceptor reveal insights on our sensation to pain, heat, and taste.	13
Editorial Board	13
The PHATE of basal epidermal cells: Calcium signaling during the cell cycle	13
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome	13
Cyclic AMP does double duty to support parallel signaling in primary cilium and cytosol	12
Editorial Board	12
ANO5 in membrane repair - Status: “It’s complicated”	12
Pannexin 1 plays a pro-survival role by attenuating P2X7 receptor-mediated Ca2+ influx	12
Editorial Board	12
Editorial Board	12
Regulation of the regulator: Endopeptidase cleavage controls the expression of a micropeptide that regulates SERCA.	12
Killing in the name of: Reversing epigenetic silencing of ITPR3 to succumb cancer cells’ resistance to chemotherapeutics	12
GPCR signalling: Yet another variant route in a highly complex road map	12
The evolution of organellar calcium mapping technologies	11
Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on “Structural insights into the regulation of RyR1 by S100A1”	11
Editorial Board	11
STIM1: The lord of the rings?	11
Barriers to exocytotic vesicle discharge	11
Neuronal and astrocyte NCX isoform/splice variants: How do they participate in Na+ and Ca2+ signalling?	11
High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors	11
Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts	11
ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry	11

Calcium signaling and genetic rare diseases: An auditory perspective	11
Modulators of TRPM7 and its potential as a drug target for brain tumours	10
Editorial Board	10
Changing of the guards while steering a familiar course	10
Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.	10
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors	10
Channeling hope for uranium-induced kidney damage and beyond with TRPML1	10
Lysosomal potassium channels	10
Scaling up neuronal Ca2+, signaling on ER ladders	10
A KRAP(y) job: Defining the localization of active IP3R	10
Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists	10
Editorial Board	10
Handling a mature calcium signature through optogenetics improves the differentiation of primary murine myotubes	10
Orai1 is in neurons: Reply to “where have all the Orais gone?”	9
Altered composition of the mitochondrial Ca2+uniporter in the failing human heart	9
Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling	9
Distinct pools of synaptic vesicles are released by different calcium channels	9
Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation	9
Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7	9
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension	9
Calcium and chloride out of sync: The role of signaling in Sjögren's salivary gland issues	9
The multifaceted role of SOCE in central synapses	9
Inhibition of TRPV1 by an antagonist in clinical trials is dependent on cholesterol binding	9
Orai1/STIMs modulators in pulmonary vascular diseases	9
Pan-cancer analysis reveals the prognostic gene CASR suppresses tumor progression and epithelial–mesenchymal transition in renal clear cell carcinoma	9
Calcium signalling in hepatic metabolism: Health and diseases	9
Investigating the landscape of intracellular [Ca2+] in live cells by rapid photoactivated cross-linking of calmodulin-protein interactions	9
Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals	9
SERCA2 phosphorylation at the heart of the disease	9
Role of STIM2 and Orai proteins in regulating TRPC1 channel activity upon calcium store depletion	9
Endogenous insulin directly protects pancreatic acinar cells in pancreatitis	8
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7	8
Uncovering a new route to pain therapy	8
The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth	8
Shocking insights for neurovascular coupling: Electrical signals ignite calcium dynamics in brain capillaries	8
Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX	8
Unravelling the complexity of the mitochondrial Ca2+ uniporter: regulation, tissue specificity, and physiological implications	8
Native SOCE complexes: Small but mighty?	8
“Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE”	8
CatSper channels in sea urchin sperm	8