Clinical Science

Article	Citations
Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis	225
α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats	185
Expression of Concern: Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression	183
Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure	182
Measuring muscle protein synthesis in humans and the influence of nutritional state	148
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities	116
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models	105
Effect of metformin in a novel experimental model of peripheral artery disease	78
Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?	74
Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad	65
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation	55
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension	53
Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients	52
Cardiovascular research at the Heart of Clinical Science	48
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury	46
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate	45
Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species	44
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2	44
Correction: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C	43
Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep	41
Antiviral activities of hemp cannabinoids	39
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species	38
Oxytocin: much more than childbirth and milk letdown	38
Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice	38
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents	38

Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction	38
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice	36
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE	35
Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease	35
Correction: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	34
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis	34
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy	33
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose	32
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis	32
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages	31
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53	31
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure	29
The traditional herbal formulation, Jianpiyifei II, reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice	28
Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis	27
Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein	27
Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension	26
Set7 methyltransferase roles in myocardial protection from chronic stressors	25
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies	25
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection	25
By what molecular mechanisms do social determinants impact cardiometabolic risk?	24
Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD	24
Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model	24
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	23
Piezo channels in JG cells do not regulate renin expression or renin release to the circulation	22
MicroRNAs as messengers of liver diseases: has the message finally been decrypted?	21
Correction: The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension	20
Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation	20
Expression of Concern: Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice	20
Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring	20
Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways	19
Cellular senescence and kidney aging	19
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms	19
Molecular and cellular regulation of psoriatic inflammation	19
Endothelin and the tumor microenvironment: a finger in every pie	19
Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention	19
Promyelocytic leukemia protein: an atherosclerosis suppressor protein?	19
Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury	18
The O-GlcNAc dichotomy: when does adaptation become pathological?	18
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis	18
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery	18
High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro	18
Correction: Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	18
Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes	17
Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy	17
SDMA as a marker and mediator in cerebrovascular disease	17
The emerging role of LRRK2 in tauopathies	16
Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis	16
Fifty years of research on the brain renin–angiotensin system: what have we learned?	16
Nutrient regulation of inflammatory signalling in obesity and vascular disease	16
Molecular regulators of defective placental and cardiovascular development in fetal growth restriction	16

SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection	16
Inflammatory liver diseases and susceptibility to sepsis	16
Klotho and calciprotein particles as therapeutic targets against accelerated ageing	15
Serpina3c Deficiency Promotes Obesity-related Hypertriglyceridemia and Inflammation through Activation of the Hif1α-glycolysis Axis in Adipose Tissue	15
Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions	15
Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis	15
NaHCO3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease	15
Brief early life angiotensin-converting enzyme inhibition attenuates the diuretic response to saline loading in sheep with solitary functioning kidney	15
Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection	15
Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease	15
G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice	15
A new mechanism of arterial calcification in diabetes: interaction between H3K18 lactylation and CHI3L1	15
Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction	15
Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs	15
Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge	15
The role of microRNAs in pregnancies complicated by maternal diabetes	15
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice	15
Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche	15
SMAD5 as a novel gene for familial pulmonary arterial hypertension	14
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies	14
The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease	14
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy	14
Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity	14
Interactions between cardiology and oncology drugs in precision cardio-oncology	14
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity	13
Regulation of Na+-K+-ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca2+-dependent cardiac metabolism	13
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway	13
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases	13
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats	13
Novel mediators of idiopathic pulmonary fibrosis	13
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability	13
Correction: New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	12
CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway	12
Cancer and sepsis	12
Mechanistic insights into the development of severe fetal growth restriction	12
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis	12
RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147	12
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease	12
When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models	12
Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)	12
Correction: Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway -Application to a biomarker for atherosclerosis	12
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice	12
Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation	12
Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer	12
DY131 activates ERRγ/TFAM axis to protect against metabolic disorders and acute kidney injury	11
Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease	11
Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy	11
The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy	11
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase	11
Epigenomic alterations in cancer: mechanisms and therapeutic potential	11
Inhibition of HDAC3 protects against kidney cold storage/transplantation injury and allograft dysfunction	11
Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD	11
The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys	11
Skeletal muscle dysfunction with advancing age	11
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice	11
Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity	11
Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	11
Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury	11
Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype	11
Emergent players in renovascular disease	11
Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease	10
Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis	10
CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p	10
Circulating biomarkers associated with placental dysfunction and their utility for predicting fetal growth restriction	10
Endothelin-1 receptor blockade impairs invasion patterns in engineered 3D high-grade serous ovarian cancer tumouroids	10
Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models	10
The immunology of heart failure with preserved ejection fraction	10
Autophagy in asthma and chronic obstructive pulmonary disease	10
A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis	10
Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease	9
Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	9
Sex differences in white adipose tissue expansion: emerging molecular mechanisms	9
Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3	9
Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice	9
Destabilisation of T cell-dependent humoral immunity in sepsis	9
Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice	9
Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency	9
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy	9
Placental syndromes and maternal cardiovascular health	9
Urocortins as biomarkers in cardiovascular disease	9

Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats	8
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men	8
Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit modelin vivo	8
Nicotine promotes AngII-induced abdominal aortic aortopathies in female and male mice: role of sex hormones	8
Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization	8
Insight into the roles of lactylation in macrophages: functions and clinical implications	8
High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH2-terminal activity	8
Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat	8
Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice	8
Blood–brain barrier lesion – a novel determinant of autonomic imbalance in heart failure and the effects of exercise training	8
TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection	8
Mechanisms of podocyte injury and implications for diabetic nephropathy	8
Circadian regulation of pulmonary disease: the importance of timing	8
Increased absorptive transcytosis and tight junction weakness in heart failure are equally corrected by exercise training and losartan	8
Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females	8
New discoveries in bile acids, gut microbiota and host interactions in health and diseases	7
CXCL5 inhibition ameliorates acute kidney injury and prevents the progression from acute kidney injury to chronic kidney disease	7
Correction: Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway	7
Bile salt signaling and bile salt-based therapies in cardiometabolic disease	7
Smoking-induced microbial dysbiosis in health and disease	7
Blocking of interleukin-1 suppresses angiotensin II-induced renal injury	7
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease	7
Myeloid cell-specific deletion of epidermal growth factor receptor aggravates acute cardiac injury	7
Pathogenesis of pneumonia and acute lung injury	7
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning	7
Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling	7
Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition	7
Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression	7
Restoring lung renin-angiotensin system balance through blood pressure control	7
Maternal intermittent fasting during pregnancy: a translational research challenge for an important clinical scenario	7
Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney	7
Importance of the gut microbiota in mice with a ‘humanized’ bile acid pool	7
PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB	7
Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury	7
Dysregulated haemostasis in thrombo-inflammatory disease	7
Physiological response to fetal intravenous lipid emulsion	7
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage	6
Immune landscape of the kidney allograft in response to rejection	6
CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis	6
Astrocytes at the intersection of ageing, obesity, and neurodegeneration	6
DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity	6
The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction	6
Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats	6
Unravelling the tangled web of hypertension and cancer	6
Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model	6
Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis	6
Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD)	6
Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats	6
TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines	6
The nonindustrialised microbiome in a modern world	6
Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection	6
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer	6
Reductions in angiotensin II type 2 receptor-mediated vasodilation contribute to increased angiotensin II vasoconstrictor sensitivity in women with preeclampsia history	6
Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension	6
Hypoxic preconditioning in renal ischaemia–reperfusion injury: a review in pre-clinical models	6
Non-invasive prenatal diagnosis (NIPD): how analysis of cell-free DNA in maternal plasma has changed prenatal diagnosis for monogenic disorders	5
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway	5
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity	5
Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome	5
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress	5
Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia	5
Retraction: Prader–Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p	5
Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation	5
Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate	5
Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen	5
Replacing bar graphs of continuous data with more informative graphics: are we making progress?	5
Small extracellular vesicles derived from patients with persistent atrial fibrillation exacerbate arrhythmogenesis via miR-30a-5p	5
Mechanisms underlying immune-related adverse events during checkpoint immunotherapy	5
Deciphering complexity of GPCR signaling and modulation: implications and perspectives for drug discovery	5
Angiotensin II-induced cardiac fibrosis and dysfunction are exacerbated by deletion of cGKI in periostin+ myofibroblasts	5
Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure	5
β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage	5
The immune niche of the liver	5
Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia	5
Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease	5
Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4	5
Updates in deep learning research in ophthalmology	5
Role of mitochondria in endogenous renal repair	5
Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics	5
How dendritic cells sense and respond to viral infections	5
Correction: Perinatal iron restriction is associated with changes in neonatal cardiac function and structure in a sex-dependent manner	5