Clinical Science

Article	Citations
Retraction: BMSC-derived exosomes carrying microRNA-122-5p promote progression of osteoblasts in osteonecrosis of the femoral head	183
Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats	166
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy	166
Aging and sex differences in salt sensitivity of blood pressure	158
Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?	147
Novel avenues to control blood pressure: targeting the renal lymphatic system	132
The double sides of NLRP3 inflammasome activation in sepsis	106
Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms	104
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies	72
Interactions between cardiology and oncology drugs in precision cardio-oncology	68
Measuring muscle protein synthesis in humans and the influence of nutritional state	62
Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis	51
Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney	49
Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver	47
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability	46
The science of science: Clinical Science launches a new translational meta-research collection	46
G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation	44
Visualization of regenerating and repairing hearts	44
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension	39
Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes	38
Regulation of Na+-K+-ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca2+-dependent cardiac metabolism	38
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway	38
miR-486-5p protects against rat ischemic kidney injury and prevents the transition to chronic kidney disease and vascular dysfunction	37
Physiological response to fetal intravenous lipid emulsion	35
Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure	35

Importance of the gut microbiota in mice with a ‘humanized’ bile acid pool	34
Is endothelin targeting finally ready for prime time?	33
PDCD10 promotes the tumor-supporting functions of TGF-β in pancreatic cancer	33
New discoveries in bile acids, gut microbiota and host interactions in health and diseases	32
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity	32
Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?	32
CXCL5 inhibition ameliorates acute kidney injury and prevents the progression from acute kidney injury to chronic kidney disease	32
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats	31
Novel mediators of idiopathic pulmonary fibrosis	31
Protecting glomerulus: role of angiotensin-II type 2 receptor	31
Targeted bisulfite resequencing of differentially methylated cytosines in pre-eclampsia reveals a skewed dynamic balance in the DNA methylation of enhancers	30
Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype	30
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation	29
Genetically inducing renal lymphangiogenesis attenuates hypertension in mice	27
α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats	27
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities	25
Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice	25
C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT2, Mas and B2 receptors	24
Perinatal iron restriction is associated with changes in neonatal cardiac function and structure in a sex-dependent manner	24
Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?	24
The tendency of anemia of inflammation in periodontal diseases	24
Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK	24
Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity	22
Autoimmune-mediated renal disease and hypertension	22
Maternal intermittent fasting during pregnancy: a translational research challenge for an important clinical scenario	22
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease	21
Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity	21
Expression of Concern: Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression	20
Early elimination of uremic toxin ameliorates AKI-to-CKD transition	20
Retraction: Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice	20
Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up	20
Transferrin promotes chondrogenic differentiation in condylar growth through inducing autophagy via ULK1-ATG16L1 axis	19
Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation	19
Clinical perspectives on vagus nerve stimulation: present and future	19
Cell-specific epigenetic changes in atherosclerosis	19
Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad	18
SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome	18
Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4	18
Flavonoid derivative DMXAA attenuates cisplatin-induced acute kidney injury independent of STING signaling	18
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models	18
Edema and lymphatic clearance: molecular mechanisms and ongoing challenges	18
Identification of endoplasmic reticulum stress-associated lncRNAs influencing inflammation and VSMC function in abdominal aortic aneurysm	17
Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep	17
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer	17
Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury	17
Emerging role of carbonic anhydrase inhibitors	17
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases	17
SMAD5 as a novel gene for familial pulmonary arterial hypertension	17
Cardiovascular research at the Heart of Clinical Science	16
Dysregulated haemostasis in thrombo-inflammatory disease	16

USP38 regulates inflammatory cardiac remodeling after myocardial infarction	16
The complement system in neurodegenerative diseases	16
Skeletal muscle dysfunction with advancing age	16
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents	15
Correction: New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	15
Obesity-associated cardiovascular risk in women: hypertension and heart failure	15
Small extracellular vesicles: a new player in GDM pathogenesis	15
Correction: Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway	15
Metabolically stable apelin analogs: development and functional role in water balance and cardiovascular function	14
Correction: Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway -Application to a biomarker for atherosclerosis	14
Correction: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C	14
Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients	14
The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases	14
Correction: Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling	14
Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice	14
Restoring lung renin-angiotensin system balance through blood pressure control	14
RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147	14
Sex-mediated effects of transglutaminase 2 inhibition on endothelial function in human resistance arteries from diabetic and non-diabetic patients	14
Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients	14
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis	14
Unravelling the tangled web of hypertension and cancer	13
Blocking of interleukin-1 suppresses angiotensin II-induced renal injury	13
Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload	13
Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction	13
Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression	13
Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling	13
Microbiota transplantation in portal hypertension: promises and pitfalls	13
A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases	13
Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)	13
Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury	13
Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs	13
Cellular and molecular mechanisms of breast cancer susceptibility	12
PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB	12
Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression	12
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice	12
Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease	12
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2	12
Circular RNAs and acute kidney injury: a Clinical Science commentary on Cao et al.	12
Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress	12
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury	12
Defining the molecular underpinnings controlling cardiomyocyte proliferation	12
A comprehensive characterization of cell-free RNA in spent blastocyst medium and quality prediction for blastocyst	12
Bile salt signaling and bile salt-based therapies in cardiometabolic disease	12
Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition	12
REV-ERBα agonist SR10067 attenuates Th2 cytokine-mediated barrier dysfunction in human bronchial epithelial cells	11
Cardiac-derived CTRP9 mediates the protection of empagliflozin against diabetes-induced male subfertility in mice	11
Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy	11
How animal models can be utilized to find new biomarkers for cardiovascular diseases	11
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase	11
Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo	11
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species	11
The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer	11
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning	11
When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models	11
Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model	11
TGFβ1, SMAD and β-catenin in pulmonary arteries of smokers, patients with small airway disease and COPD: potential drivers of EndMT	11
Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice	10
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis	10
Antiviral activities of hemp cannabinoids	10
Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension	10
Oxytocin: much more than childbirth and milk letdown	10
The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension	10
Endothelial progenitor cells in pregnancy-related diseases	10
Complex regulation of tau phosphorylation by the endothelin system in brain microvascular endothelial cells (BMVECs): link to barrier function	10
Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer	10
Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia	10
Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype	10
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice	9
Mechanistic insights into the development of severe fetal growth restriction	9
Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm	9
Cancer and sepsis	9
Cholesterol metabolism: a new molecular switch to control inflammation	9
Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer	9
Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation	9
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate	9
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease	9
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE	9
Smoking-induced microbial dysbiosis in health and disease	9
CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signalling pathway	9
Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species	9

Maternal microvascular dysfunction during preeclamptic pregnancy	9
New mechanisms for the kidney-protective effect of alkali in chronic kidney disease	8
The acute pressure natriuresis response is suppressed by selective ETA receptor blockade	8
Eicosanoid receptors as therapeutic targets for asthma	8
The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy	8
Therapeutic use of calpeptin in COVID-19 infection	8
Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection	8
In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system	8
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages	8
Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress	8
Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis	8
Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose	8
Autophagy in asthma and chronic obstructive pulmonary disease	8
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury	8
Renal damage-induced hepcidin accumulation contributes to anemia in angiotensinogen-deficient mice	8
Circulating biomarkers associated with placental dysfunction and their utility for predicting fetal growth restriction	8
Epigenomic alterations in cancer: mechanisms and therapeutic potential	8
Quantifying muscle blood flow: a transformative breakthrough in the science of human exercise physiology	8
Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension	8
Endothelin-1 impairs skeletal muscle myogenesis and development via ETB receptors and p38 MAPK signaling pathway	7
Astrocytes at the intersection of ageing, obesity, and neurodegeneration	7
Set7 methyltransferase roles in myocardial protection from chronic stressors	7
The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys	7
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice	7
Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration	7
COVID-19 and abnormal uterine bleeding: potential associations and mechanisms	7
Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by angiotensin-(1–7)	7
The nonindustrialised microbiome in a modern world	7
Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury	7
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure	7
DY131 activates ERRγ/TFAM axis to protect against metabolic disorders and acute kidney injury	7
Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model	7
Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model	7
Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease	7
Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity	7
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53	7
Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition	7
WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway	6
Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	6
Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair	6
Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis	6
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose	6
The immunology of heart failure with preserved ejection fraction	6
Identifying mitigating strategies for endothelial cell dysfunction and hypertension in response to VEGF receptor inhibitors	6
Emergent players in renovascular disease	6
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis	6
A time to heal: microRNA and circadian dynamics in cutaneous wound repair	6
Immune landscape of the kidney allograft in response to rejection	6
Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD	6
Maternal voluntary wheel running modulates glucose homeostasis, the gut microbiota and its derived fecal metabolites in offspring	6
Inhibition of HDAC3 protects against kidney cold storage/transplantation injury and allograft dysfunction	6
There is more to life than serum vitamin D: a lesson from the past	6
The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation	6
Fifty years of impact on treating bone disease: a commentary on Gasser et al.	6
Nasogastric bolus administration of a protein-rich drink augments insulinaemia and aminoacidaemia but not whole-body protein turnover or muscle protein synthesis versus oral administration	6
Revisiting blood pressure and body fluid status	6
Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease	6
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility	5
Correction: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	5
Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis	5
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies	5
Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection	5
CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis	5
Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy	5
Assessing hypothalamic pituitary gonadal function in reproductive disorders	5
To target cellular senescence in diabetic kidney disease: the known and the unknown	5
Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation	5
Correction: The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease	5
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy	5
Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats	5
Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein	5
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	5
Recent advances in understanding ion transport mechanisms in polycystic kidney disease	5
Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension	5
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage	5
By what molecular mechanisms do social determinants impact cardiometabolic risk?	5
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer	5
Correction: MKP2 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells through a JNK-dependent pathway	5
Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway	5
Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension	5
The traditional herbal formulation, Jianpiyifei II, reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice	5
Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD)	5
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection	5
Novel pharmacological approaches in abdominal aortic aneurysm	5
DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity	5
Colchicine protects against the development of experimental abdominal aortic aneurysm	5