Clinical Science

Article	Citations
α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats	405
Measuring muscle protein synthesis in humans and the influence of nutritional state	271
Expression of Concern: Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression	264
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities	221
Chronic stress and the IL-10-mediated immunoregulatory loop in the pathogenesis of periodontitis	193
Loss of LCAT function aggravates metabolic-associated steatohepatitis (MASH) in golden Syrian hamster	167
Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?	78
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation	77
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models	64
Effect of metformin in a novel experimental model of peripheral artery disease	61
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension	54
Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure	53
Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad	52
Cardiovascular research at the Heart of Clinical Science	52
Correction: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C	51
Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep	49
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice	46
Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease	46
Antiviral activities of hemp cannabinoids	45
Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction	42
The multifactorial role of HDAC9 at the maternal–fetal interface in the pathogenesis of preeclampsia	41
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate	39
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2	38
Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients	37
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis	36

Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury	35
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species	32
Correction: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	31
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53	30
Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model	29
Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis	28
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose	27
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy	27
Set7 methyltransferase roles in myocardial protection from chronic stressors	27
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection	26
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies	26
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure	25
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages	25
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis	24
By what molecular mechanisms do social determinants impact cardiometabolic risk?	22
Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension	22
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	22
Correction: The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension	21
Expression of Concern: Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice	21
MicroRNAs as messengers of liver diseases: has the message finally been decrypted?	21
Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD	21
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms	20
Piezo channels in JG cells do not regulate renin expression or renin release to the circulation	20
Molecular and cellular regulation of psoriatic inflammation	20
Platelets from Older Adults Exhibit Differences in Mitochondrial Function Associated with Impaired Glucose Metabolism	20
Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation	20
Fentanyl exposure during preconception and gestation permanently dysregulates endogenous opioid peptides and sympathoadrenal-medullary axis in the offspring	20
Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways	20
Endothelin and the tumor microenvironment: a finger in every pie	20
Cellular senescence and kidney aging	20
Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes	19
Correction: Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	19
Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis	19
Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention	19
The novel AT2 receptor ligand, β-Pro7 Ang III, induces equivalent anti-fibrotic effects to Compound 21 but broader anti-fibrotic effects than pirfenidone in mice with bleomycin-induced pulmonary fibro	19
High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro	19
SDMA as a marker and mediator in cerebrovascular disease	18
Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury	18
Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy	18
SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection	18
The emerging role of LRRK2 in tauopathies	17
The O-GlcNAc dichotomy: when does adaptation become pathological?	17
Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction	17
Double-edged mitophagy: balancing inflammation and resolution in lung disease	17
Inflammatory liver diseases and susceptibility to sepsis	16
Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs	16
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis	16
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery	16
Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection	16
Impact of the natural female reproductive aging on the rat serum lipidome	16

Molecular regulators of defective placental and cardiovascular development in fetal growth restriction	16
G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice	15
Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge	15
Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions	15
Brief early life angiotensin-converting enzyme inhibition attenuates the diuretic response to saline loading in sheep with solitary functioning kidney	15
The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease	15
Urine-derived renal epithelial cells for deep phenotyping and transcriptomic response to therapy in Fabry disease	15
Retraction: Overexpression of TrpC5 promotes tumor metastasis via the HIF-1α/Twist signaling pathway in colon cancer	15
Serpina3c deficiency promotes obesity-related hypertriglyceridemia and inflammation through activation of the Hif1α-glycolysis axis in adipose tissue	14
Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease	14
NaHCO3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease	14
Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis	14
COPD: the role of neutrophils in inflammation, pathophysiology, and as drug targets	14
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice	13
Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity	13
A new mechanism of arterial calcification in diabetes: interaction between H3K18 lactylation and CHI3L1	13
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy	13
Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche	13
The role of microRNAs in pregnancies complicated by maternal diabetes	13
Novel mediators of idiopathic pulmonary fibrosis	12
Regulation of Na+-K+-ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca2+-dependent cardiac metabolism	12
SMAD5 as a novel gene for familial pulmonary arterial hypertension	12
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies	12
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases	12
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway	12
Expression of Concern: Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats	12
RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147	11
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity	11
CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway	11
Hypertension: a lymphatic disease?	11
When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models	11
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice	11
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase	11
HO-1 modulates obesity-related renal sodium metabolism via oxidative stress and Na/K-ATPase signaling	11
Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer	11
Skeletal muscle dysfunction with advancing age	11
Correction: New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	11
Elevated phenylacetylglutamine caused by gut dysbiosis associated with type 2 diabetes increases neutrophil extracellular traps formation and exacerbates brain infarction	11
Mechanistic insights into the development of severe fetal growth restriction	11
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis	10
Cancer and sepsis	10
The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys	10
Circulating biomarkers associated with placental dysfunction and their utility for predicting fetal growth restriction	10
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease	10
Emergent players in renovascular disease	10
Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease	10
Autophagy in asthma and chronic obstructive pulmonary disease	10
Correction: Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway -Application to a biomarker for atherosclerosis	10
Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation	10
Epigenomic alterations in cancer: mechanisms and therapeutic potential	10
Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD	10
Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury	10
Placental syndromes and maternal cardiovascular health	9
Combined aerobic and resistance exercise training restores perivascular adipose tissue function in the thoracic aorta of rats with heart failure	9
CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p	9
The immunology of heart failure with preserved ejection fraction	9
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice	9
The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy	9
Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease	9
Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	9
Destabilisation of T cell-dependent humoral immunity in sepsis	9
Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy	9
Inhibition of HDAC3 protects against kidney cold storage/transplantation injury and allograft dysfunction	9
Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity	9
Blood pressure reduction and anti-inflammatory macrophage augmentation attenuate uterine immune dysregulation and inflammation in mice with salt-sensitive hypertension	9
Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models	9
Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice	9
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy	9
Sympathetic regulation of the host immune response to bacterial sepsis	9
Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	9
DY131 activates ERRγ/TFAM axis to protect against metabolic disorders and acute kidney injury	9
Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3	8
Increased absorptive transcytosis and tight junction weakness in heart failure are equally corrected by exercise training and losartan	8
Circadian regulation of pulmonary disease: the importance of timing	8
Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization	8
TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection	8
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men	8
Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency	8
Nicotine promotes AngII-induced abdominal aortic aortopathies in female and male mice: role of sex hormones	8
pH-sensor GPR68 plays a role in how dietary fibre lowers blood pressure in a preclinical model of hypertension	8

Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice	8
Aging and sinus node dysfunction: mechanisms and future directions	8
Blood–brain barrier lesion – a novel determinant of autonomic imbalance in heart failure and the effects of exercise training	8
Pathogenesis of pneumonia and acute lung injury	8
Endothelin-1 receptor blockade impairs invasion patterns in engineered 3D high-grade serous ovarian cancer tumouroids	8
Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease	8
Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females	8
Myeloid cell-specific deletion of epidermal growth factor receptor aggravates acute cardiac injury	8
Mechanisms of podocyte injury and implications for diabetic nephropathy	8
Insight into the roles of lactylation in macrophages: functions and clinical implications	8
Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice	8
Physiological response to fetal intravenous lipid emulsion	7
Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection	7
Molecular drivers of osteogenesis imperfecta: a cellular and extracellular collagen disease	7
Bile salt signaling and bile salt-based therapies in cardiometabolic disease	7
Immune landscape of the kidney allograft in response to rejection	7
PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB	7
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer	7
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease	7
Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model	7
New discoveries in bile acids, gut microbiota and host interactions in health and diseases	7
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning	7
Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition	7
Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis	7
Correction: Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway	7
The nonindustrialised microbiome in a modern world	7
CXCL5 inhibition ameliorates acute kidney injury and prevents the progression from acute kidney injury to chronic kidney disease	7
Dysregulated haemostasis in thrombo-inflammatory disease	7
Restoring lung renin-angiotensin system balance through blood pressure control	7
Evaluating the role of 2-hydroxyestradiol in modulating TNF-α signaling and its implications in rheumatoid arthritis	7
Smoking-induced microbial dysbiosis in health and disease	7
Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression	7
Reductions in angiotensin II type 2 receptor-mediated vasodilation contribute to increased angiotensin II vasoconstrictor sensitivity in women with preeclampsia history	7
Importance of the gut microbiota in mice with a ‘humanized’ bile acid pool	7
Astrocytes at the intersection of ageing, obesity, and neurodegeneration	7
TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines	6
Exosome-mediated modulation of macrophage polarization and inflammation in early Klebsiella pneumoniae lung infections	6
Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics	6
Retraction: Prader–Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p	6
The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction	6
Deciphering complexity of GPCR signaling and modulation: implications and perspectives for drug discovery	6
Role of mitochondria in endogenous renal repair	6
DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity	6
Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD)	6
CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis	6
Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia	6
Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension	6
Correction: Perinatal iron restriction is associated with changes in neonatal cardiac function and structure in a sex-dependent manner	6
In vivo and ex vivo cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia	6
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage	6
Angiotensin II-induced cardiac fibrosis and dysfunction are exacerbated by deletion of cGKI in periostin+ myofibroblasts	6
Evaluating skeletal muscle wasting and weakness in models of critical illness	6
Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome	6
Retraction: Differential temporal inhibition of mitochondrial fission by Mdivi-1 exerts effective cardioprotection in cardiac ischemia/reperfusion injury	6
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway	5
A normative microbiome is not restored following kidney transplantation	5
Replacing bar graphs of continuous data with more informative graphics: are we making progress?	5
Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation	5
Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease	5
Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen	5
Chemokine receptors in vascular biology: a review of current evidence, implications, and therapeutic targets for hypertension	5
Complement C3 in panvascular disease: a central integrator of immune signaling and vascular remodeling	5
β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage	5
Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4	5
Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure	5
Non-invasive prenatal diagnosis (NIPD): how analysis of cell-free DNA in maternal plasma has changed prenatal diagnosis for monogenic disorders	5
The dietary exposome: a brief history of diet, longevity, and age-related health in rodents	5
Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway	5
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity	5
Mechanisms underlying immune-related adverse events during checkpoint immunotherapy	5
Small extracellular vesicles derived from patients with persistent atrial fibrillation exacerbate arrhythmogenesis via miR-30a-5p	5