OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Science is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Emerging role of carbonic anhydrase inhibitors	111
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer	96
The complex role of adipokines in obesity, inflammation, and autoimmunity	95
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease	91
Covid-19: the renin–angiotensin system imbalance hypothesis	78
Bidirectional interaction of airway epithelial remodeling and inflammation in asthma	77
Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy	76
Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases	73
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway	69
Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission	68
ACE2 and gut amino acid transport	66
Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways	65
Pathogenesis of pneumonia and acute lung injury	65
Emerging roles for the IL-6 family of cytokines in pancreatic cancer	61
The molecular mechanism of mechanotransduction in vascular homeostasis and disease	61
Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity	59
Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1	55
Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis	54
Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities	54
Mechanisms of podocyte injury and implications for diabetic nephropathy	47
Cholesterol metabolism: a new molecular switch to control inflammation	46
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV	45
Cardiotoxic effects of angiogenesis inhibitors	45
Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression	44
Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice	44

Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19	43
Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function	41
The immune niche of the liver	41
Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway	40
Inflammation: a putative link between phosphate metabolism and cardiovascular disease	40
Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets	39
The GCN5: its biological functions and therapeutic potentials	39
ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19	39
Myeloid-derived suppressor cells shift Th17/Treg ratio and promote systemic lupus erythematosus progression through arginase-1/miR-322-5p/TGF-β pathway	39
Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice	38
Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice	38
SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure	37
Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease	36
Eicosanoid blood vessel regulation in physiological and pathological states	35
Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT2-receptor agonists	35
ACE2: from protection of liver disease to propagation of COVID-19	35
Vascular toxicity associated with anti-angiogenic drugs	32
ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease	32
Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis	32
Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis	32
Klotho and calciprotein particles as therapeutic targets against accelerated ageing	32
Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease	32
Targeting mitochondrial fitness as a strategy for healthy vascular aging	31
Host cell glutamine metabolism as a potential antiviral target	31
miR-20a-5p is enriched in hypoxia-derived tubular exosomes and protects against acute tubular injury	30
ACE2 in the renin–angiotensin system	30
Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor	28
Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)	28
Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy	28
Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis	28
Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies	28
Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics	27
Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes	27
M1/M2 macrophages and their overlaps – myth or reality?	27
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility	27
Increased susceptibility to dextran sulfate-induced mucositis of iron-overload β-thalassemia mice, another endogenous cause of septicemia in thalassemia	26
Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications	26
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid	25
Epigenetic processes during preeclampsia and effects on fetal development and chronic health	25
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability	25
Back to the future: re-establishing guinea pigin vivoasthma models	25
Non-alcoholic fatty liver disease: a metabolic burden promoting atherosclerosis	25
Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies	24
LncRNA HOTAIR modulates hepatitis B virus transcription and replication by enhancing SP1 transcription factor	23
Lipotoxicity: a driver of heart failure with preserved ejection fraction?	23
SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome	22
Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice	22
Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury	22
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway	22
Alternative splicing of ACE2 possibly generates variants that may limit the entry of SARS-CoV-2: a potential therapeutic approach using SSOs	22

CYP1B1 as a therapeutic target in cardio-oncology	22
Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease	22
How accurate are citations of frequently cited papers in biomedical literature?	21
Clinical perspectives on vagus nerve stimulation: present and future	21
Obesity-associated cardiovascular risk in women: hypertension and heart failure	21
Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments	21
Pathogenic role of human C-reactive protein in diabetic retinopathy	21
Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway	20
Autophagy in asthma and chronic obstructive pulmonary disease	20
Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure	20
No evidence for brain renin–angiotensin system activation during DOCA-salt hypertension	20
The PAR-1 antagonist vorapaxar ameliorates kidney injury and tubulointerstitial fibrosis	20
Updates in deep learning research in ophthalmology	20
SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in	20
Metformin alleviates hyperuricaemia-induced serum FFA elevation and insulin resistance by inhibiting adipocyte hypertrophy and reversing suppressed white adipose tissue beiging	20
Molecular mechanisms of anthracycline cardiovascular toxicity	19
NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia	19
Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease	19
The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases	19
RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer	19
Skeletal muscle redox signaling in rheumatoid arthritis	19
Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis	18
Forsythoside A protects against lipopolysaccharide-induced acute lung injury through up-regulating microRNA-124	18
Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids	18
Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis	17
KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages	17
Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure	17
P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model	17
Eicosanoid receptors as therapeutic targets for asthma	17
Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms	17
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells	17
Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function	16
How dendritic cells sense and respond to viral infections	16
Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor	16
Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction	16
Oxytocin signalling in dendritic cells regulates immune tolerance in the intestine and alleviates DSS-induced colitis	16
HMGB1 A box protects neurons by potently inhibiting both microglia and T cell-mediated inflammation in a mouse Parkinson’s disease model	16
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases	16
Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19	16
Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors	15
Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers	15
ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery	15
p110δ PI3K as a therapeutic target of solid tumours	15
IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture	15
CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis	15
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway	15
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling	15
Using nuclear envelope mutations to explore age-related skeletal muscle weakness	15
Cell-specific epigenetic changes in atherosclerosis	15
Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation	14
Key role for EphB2 receptor in kidney fibrosis	14
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress	14
ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer	14
Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathway	14
IGF2 deficiency causes mitochondrial defects in skeletal muscle	14
Potential role of diacylglycerol kinases in immune-mediated diseases	14
Brain angiotensin converting enzyme-2 in central cardiovascular regulation	14
DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway	14
Early elimination of uremic toxin ameliorates AKI-to-CKD transition	14
Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression	14
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms	14
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	14
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents	14
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats	14
The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension	13
Phosphate and fibroblast growth factor 23 in diabetes	13
Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice	13
Deregulation of miRNAs-cMYC circuits is a key event in refractory celiac disease type-2 lymphomagenesis	13
Non-invasive prenatal diagnosis (NIPD): how analysis of cell-free DNA in maternal plasma has changed prenatal diagnosis for monogenic disorders	13
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?	13
Smoking-induced microbial dysbiosis in health and disease	13
Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions	13
Gastrin, via activation of PPARα, protects the kidney against hypertensive injury	13
ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders	13
Homocysteine induces melanocytes apoptosis via PERK–eIF2α–CHOP pathway in vitiligo	13
Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats	13