OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Science is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis	225
α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats	185
Expression of Concern: Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression	183
Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure	182
Measuring muscle protein synthesis in humans and the influence of nutritional state	148
Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities	116
The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models	105
Effect of metformin in a novel experimental model of peripheral artery disease	78
Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?	74
Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad	65
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation	55
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension	53
Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients	52
Cardiovascular research at the Heart of Clinical Science	48
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury	46
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate	45
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2	44
Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species	44
Correction: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C	43
Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep	41
Antiviral activities of hemp cannabinoids	39
Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction	38
Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species	38
Oxytocin: much more than childbirth and milk letdown	38
Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice	38

Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents	38
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice	36
Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE	35
Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease	35
Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis	34
Correction: Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma	34
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy	33
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis	32
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose	32
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53	31
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages	31
Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of lowering blood pressure	29
The traditional herbal formulation, Jianpiyifei II, reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice	28
Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein	27
Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis	27
Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension	26
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection	25
Set7 methyltransferase roles in myocardial protection from chronic stressors	25
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies	25
Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model	24
By what molecular mechanisms do social determinants impact cardiometabolic risk?	24
Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD	24
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	23
Piezo channels in JG cells do not regulate renin expression or renin release to the circulation	22
MicroRNAs as messengers of liver diseases: has the message finally been decrypted?	21
Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring	20
Correction: The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension	20
Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation	20
Expression of Concern: Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice	20
Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention	19
Promyelocytic leukemia protein: an atherosclerosis suppressor protein?	19
Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways	19
Cellular senescence and kidney aging	19
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms	19
Molecular and cellular regulation of psoriatic inflammation	19
Endothelin and the tumor microenvironment: a finger in every pie	19
High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro	18
Correction: Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research	18
Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury	18
The O-GlcNAc dichotomy: when does adaptation become pathological?	18
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis	18
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery	18
Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy	17
SDMA as a marker and mediator in cerebrovascular disease	17
Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes	17
Molecular regulators of defective placental and cardiovascular development in fetal growth restriction	16
SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection	16
Inflammatory liver diseases and susceptibility to sepsis	16
The emerging role of LRRK2 in tauopathies	16
Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis	16

Fifty years of research on the brain renin–angiotensin system: what have we learned?	16
Nutrient regulation of inflammatory signalling in obesity and vascular disease	16
Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge	15
Klotho and calciprotein particles as therapeutic targets against accelerated ageing	15
The role of microRNAs in pregnancies complicated by maternal diabetes	15
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice	15
Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche	15
Brief early life angiotensin-converting enzyme inhibition attenuates the diuretic response to saline loading in sheep with solitary functioning kidney	15
Serpina3c Deficiency Promotes Obesity-related Hypertriglyceridemia and Inflammation through Activation of the Hif1α-glycolysis Axis in Adipose Tissue	15
Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection	15
Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions	15
Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis	15
NaHCO3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease	15
Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction	15
Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease	15
Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs	15
G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice	15
A new mechanism of arterial calcification in diabetes: interaction between H3K18 lactylation and CHI3L1	15
SMAD5 as a novel gene for familial pulmonary arterial hypertension	14
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies	14
The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease	14
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy	14
Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity	14
Interactions between cardiology and oncology drugs in precision cardio-oncology	14
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats	13
Novel mediators of idiopathic pulmonary fibrosis	13
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability	13
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity	13
Regulation of Na+-K+-ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca2+-dependent cardiac metabolism	13
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway	13
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases	13
Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer	12
Correction: New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis	12
CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway	12
Cancer and sepsis	12
Mechanistic insights into the development of severe fetal growth restriction	12
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis	12
RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147	12
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease	12
When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models	12
Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)	12
Correction: Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway -Application to a biomarker for atherosclerosis	12
Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice	12
Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation	12