OOIR: Observatory of International Research

Papers

(The TQCC of Drug and Chemical Toxicology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Investigation of the role of K _ATP channels in the cytotoxic effect of cypermethrin on rat-derived aortic smooth muscle cells	27
Population pharmacokinetics and pharmacodynamics of L-asparaginase and its impact on the development of pancreatitis and hypersensitivity reactions in children with leukemia under treatment	26
Changes in hormones, Leukocyte Telomere Length (LTL), and p16^INK4a expression in SM-exposed individuals in favor of the cellular senescence	24
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea	22
The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity	19
Amelioration of metabolic disorders in H9C2 cardiomyocytes induced by PM _2.5 treated with vitamin C	18
Antioxidant capacity, acute and sub-acute oral toxicity, and in vivo anti-inflammatory effects of Tetradenia riparia	18
Oxidative stress and inflammatory markers in streptozotocin-induced acute and subacute toxicity response	17
Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum)extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model	17
The effect on paraoxonase and arylesterase activities of bee pollen against deltamethrin in Cyprinus carpio	17
Lipid profile, toxicity, and antioxidant potential of flavonoid-rich babassu mesocarp extract after simulated human digestion	15
Gastroprotective mechanism of Talinum triangulare on ethanol-induced gastric ulcer in Wistar rats via inflammatory, antioxidant, and H	15
Genotoxic effects of gadobutrol and gadoversetamide active substances used in magnetic resonance imaging in human peripheral lymphocytesin vitro	15
In vitro evaluation of the selective cytotoxicity and genotoxicity of three synthetic ortho -nitrobenzyl derivatives in human cancer cell lines, with	15
Unraveling the hepatoprotective and anti-pancreatic cancer potential of Caralluma europaea : a comprehensive in vivo, in vitro and in sili	14
Pelargonidin ameliorates reserpine-induced neuronal mitochondrial dysfunction and apoptotic cascade: a comparative in vivo study	13
Linolenic acid stimulates eryptosis and hemolysis through oxidative stress and CK1α/MLKL: protective role of melatonin, urea, and polyethylene glycol	13
NO-mediated DNA damage induced by polystyrene nanoparticles triggers program cell death in mesenchymal stem cells	13
Evaluation of acute and 28-day repeated dose toxicity of Tolypocladium sinense soft capsule in Sprague-Dawley rats	13
Tauroursodeoxycholic acid suppresses biliary epithelial cell apoptosis and endoplasmic reticulum stress by miR-107/NCK1 axis in a FXR-dependent manner	12
Screening and toxicity evaluation of natural compounds as adenosine 2a and 2b receptor ligands: insights from molecular docking, dynamics, and ADMET analysis	12
Acute and sub-acute toxicological evaluation of a bioactive compound mixture in healthy Wistar rats	12
Content of potentially toxic elements (PTEs) in coffee and coffee-based products: a meta-analysis study, Systematic review, and health risk assessment	12
Investigation of oxidative, inflammatory and apoptotic effects of favipiravir use alone and combined with vitamin C on brain tissue of elderly rats	11
Evaluation of therapeutic effects of royal jelly versus Nigella sativa oil on some brain areas affected by acute methanol poisoning in rats	11

Synergistic hepatoprotective effects of ω-3 and ω-6 fatty acids from Indian flax and sesame seed oils against CCl ₄ -induced oxidative stress-mediated liver damage i	10
Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats	10
Toothpastes for children and their detergent contents affect molecular mechanisms of odontogenesis in zebrafish embryos	10
Silymarin attenuates cobalt chloride-induced redox imbalance and cardio-renal dysfunctions in rats	10
Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats	10
Renal tubular response to titanium dioxide nanoparticles exposure	10
Fumaric acid protects rats from ciprofloxacin-provoked depression through modulating TLR4, Nrf-2, and p190-rho GTP	10
Toxicity of pesticide cocktails in amphibian larvae: understanding the impact of agricultural activity on aquatic ecosystems in the Salado River basin, Argentina	10
Assessment of morin hydrate as a renal protective agent in rats subjected to methotrexate-induced nephrotoxicity	10
Aspirin’s therapeutic mechanism against diesel particulate matter-induced lung injury revealed by network pharmacology and experimental models	10
Probiotics modulation of the endotoxemic effect on the gut and liver of the lipopolysaccharide challenged mice	9
TiO ₂ nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish ( Danio	9
Naringenin mitigates cadmium-induced cell death, oxidative stress, mitochondrial dysfunction, and inflammation in KGN cells by regulating the expression of sirtuin-1	9
Toxicity study of compound honeysuckle moisturizing Chinese herbal extract by oral gavage for 13 weeks in sprague dawley rats	9
Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations in zebrafish	9
Modulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells	9
Effect of adenosine triphosphate on methylphenidate-induced oxidative and inflammatory kidney damage in rats	8
Long term integrated biomarker responses in freshwater African catfish Clarias gariepinus exposed to a new brand of herbicide fluazifop-p-butyl	8
Prognostic value of systemic immune-inflammation index and monocyte-to-HDL-cholesterol ratio in early cardio-cerebral complications in elderly patients with acute severe carbon monoxide poisoning	8
Damage to the sarcoplasmic reticulum by venom of the Mexican black-tailed rattlesnake ( Crotalus molossus nigrescens ): inhibition of the Ca ²⁺	8
Study on the acute and subchronic oral toxicity of Calculus Bovis Sativus in rats	8
Toxicological assays in the evaluation of safety assessment of fibrinolytic enzymes	8
Single acute and repeated subacute toxicity evaluations of Annona atemoya leaf extract with in vitro anti-inflammatory potential	8
Pentoxifylline inhibits phosgene-induced lung injury via improving hypoxia	8
Cyclosporine-A induced cytotoxicity within HepG2 cells by inhibiting PXR mediated CYP3A4/CYP3A5/MRP2 pathway	8
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway	8
Assessment of the toxicity of different antiretroviral drugs and their combinations on Sertoli and Leydig cells	7
Kidney damage following a 90-day subchronic inhalation exposure to HTP aerosol in SD rats	7
Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats	7
Uncoupling as initiating event in mitochondrial dysfunction after diuron exposure	7
Pharmacological synergistic multi-target of Curcuma longa compounds to minimise the ototoxic effects and resistance of cisplatin in ovarian cancer treatm	7
Safety assessment of Wuzhuyu decoction extract: acute and subacute oral toxicity studies in rats	7
Chronic levamisole exposure in male rats alters sexual behavior and induces apoptosis in the testis	7
B-Raf inhibitor vemurafenib counteracts sulfur mustard-induced epidermal impairment through MAPK/ERK signaling	7
Evaluation of toxicological profile of omeprazole degradation impurities in an intravenous drug product: omeprazole-sulfone and omeprazole-N-oxide	7
Assessment of the effect of sodium tetraborate on oxidative stress, inflammation, and apoptosis in lead-induced nephrotoxicity	7
Both acute glyphosate and the aminomethylphosphonic acid intoxication decreased the acetylcholinesterase activity in rat hippocampus, prefrontal cortex and gastrocnemius muscle	7
Phycocyanin improved alcohol-induced hepatorenal toxicity and behavior impairment in Wistar rats	6
Eight-year epidemiological study for drug poisoning in Qassim, Saudi Arabia, 2008–2015	6
Computational design and evaluation of low-toxicity saquinavir analogues targeting the catalytic dyad and oxyanion-hole loop of SARS-CoV-2 Mpro: insights from ensemble docking, molecular dynamics, dyn	6
Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos	6
Effect ofMoringa oleiferaleaf extract on valproate-induced oxidative damage in muscle	6
Salvianolic acid A suppresses CCl₄-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways	6
Effects of methiopropamine on cognitive function and monoaminergic systems in mice	6
Physcion alleviates cisplatin-induced apo in HK-2 cells by activating the apo signaling for treating acute kidney injury: Integrating network pharmacology and informatics	6
Fluoroquinolone antibiotics in the aquatic environment: environmental distribution, the research status and eco-toxicity	6
A comparison of the potential of melatonin and tryptophan to ameliorate CCl ₄ -induced hepatic and renal toxicity in Wistar rats	6
Computational modeling ( in silico ) methods combined with ecotoxicological experiments ( in vivo ) to predict the environmental risks of	6
Omeprazole induces profibrotic gene expression in rat kidney: implication of TGF-β/Smad signaling pathway	6
Genotoxic and genoprotective effects of phytoestrogens: a systematic review	6

Comparative cytotoxicity induced by parabens and their halogenated byproducts in human and fish cell lines	6
Pre-clinical and cellular safety assessment of oral administered DHA rich microalgae oil from Schizochytrium sp. (Strain ATCC-20889): acute, sub-chronic and genotoxicity	6
Nigella sativa oil reduces oxidative/nitrosative stress in the salivary gland of rats exposed to total cranial irradiation	6
MiR-27b-3p ameliorates DOX-induced cardiotoxicity by suppressing myocardial inflammation and oxidative stress in mice and cardiomyocytes	5
Exploring health beneficial effects of poisonous mushroom Paxillus involutus Batsch Fr.	5
New oxomethacrylate and acetamide: synthesis, characterization, and their computational approaches: molecular docking, molecular dynamics, and ADME analyses	5
Induced oxidative stress and apoptosis by 1-bromopropane in SH-SY5Y cells correlates with inhibition of Nrf2 function	5
Effects of burnt tire-ash on Na⁺/K⁺, Ca²⁺-ATPase, serum immunoglobulin and brain acetylcholinesterase activities in clarias gariepinus (Burchell, 1822)	5
Potential neuroprotective effects of 2-hydroxypropyl-β cyclodextrin against amyloid β (1-42)-induced neurotoxicity on the rat hippocampus	5
Evaluation of XQ528 tartrate on embryo-fetus developmental toxicity in SD rats and genotoxicity	5
Phytochemical composition, cytotoxicity, antioxidant and antimicrobial responses of Lavandula dentata L. grown under different levels of heavy metals stress condition	5
Glyphosate in the Iberian Peninsula: Evaluating risks to Iberian wildlife	5
In vitro and in vivo genotoxicity assessments of Ficus erecta Thunb. leaves ext	5
Effects of acetaminophen exposure on behavior and erythrocyte nuclear morphology of juvenile Oreochromis niloticus	5
Reproductive and developmental toxicity of α-terpineol in Wistar rats	5
Artemisia vulgaris L., Artemisia alba Turra and their constituents reduce mitomycin C-induced genomic instability in human peripheral blood lymphocyte	5
Single and repeat-dose toxicity and local tolerance assessment of newly developed oil emulsion adjuvant formulations for veterinary purposes	5
Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems	5
Toxicogenetic profile of the monoterpene alpha-terpineol on normal and tumor eukaryotic cells	5
Cardiotoxicity induced by xanthatin via activating apoptosis and ERS pathways in zebrafish	5
Dermatoprotective effect of Moringa oleifera leaf extract on sodium valproate-induced skin damage in rats	5
Long-term toxicity of fluoroquinolones: a comprehensive review	5
Co-administered chitosan and ivy leaf extract reduce deltamethrin-induced testicular toxicity	5
A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine	5
In vivo and in silico toxicity profiling of a novel 1,5-benzodiazepine derivative	5
Exploring the toxicity profile of coriander ( C. sativum L.) essential oil: implications for translational toxicological research	5
Oxidative stress and toxicity induced by copper and zinc oxide nanoparticles in liver and kidney tissues of male mice	4
Correction	4
Mechanistic study of copper oxide, zinc oxide, cadmium oxide, and silver nanoparticles-mediated toxicity on the probiotic Lactobacillus reuteri	4
The role of ginger’s extract and N-acetylcysteine against docetaxel-induced oxidative stress and genetic disorder	4
Correction	4
Investigation of the phytochemical composition and remedial effects of southern grape hyacinth (Muscari neglectum Guss. ex Ten.) plant extract against carbon tetrachloride-induced oxidative str	4
Liquid mosquito repellent induces toxic effects in zebrafish	4
Furan impairs cell function by inducing oxidative stress, DNA damage and apoptosis in mouse Sertoli cells in vitro	4
Heavy metal mixture induced hippocampal toxicity involve biometal accumulation, increase in oxidative stress, inflammation, and caspase-3 activation in rats via Nrf-2/HO-1/BDNF pathway	4
Phytochemical analysis, in silico study and toxicity profile ofCycas pectinataBuch.-Ham seed in mice	4
Evaluation of antifungal activity, mechanisms of action and toxicological profile of the synthetic amide 2-chloro- N -phenylacetamide	4
In vitro cytogenotoxic evaluation of aripiprazole on human peripheral lymphocytes and computational molecular docking analysis	4
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate	4
Ferroptosis: action and mechanism of chemical/drug-induced liver injury	4
Is a non-cytotoxic and non-genotoxic novel bioinspired dipeptide structure synthesis possible for theragnostic applications?	4
Cadmium and ketoprofen accumulation influences aquatic ecosystem demonstrated using in-vivo zebrafish model	4
Quercetin prevents methylmercury-induced mitochondrial dysfunction in the cerebral cortex of mice	4
Further insights into the impact of rebamipide on gentamicin-induced nephrotoxicity in rats: modulation of SIRT1 and β-catenin/cyclin D1 pathways	4
Potential protective effects of Acacia nilotica (L.) against gentamicin - induced nephrotoxicity by suppressing renal redox imbalance, inflammatory stress and caspase-de	4
Possible genotoxic effects of dapagliflozin using SMART and comet tests, and behavioral toxicity in Drosophila melanogaster	4
Di (2-ethyl hexyl) phthalate and its metabolite-induced metabolic syndrome: a review of molecular mechanisms	4
Acute toxicity and biodistribution assessment of quantum dots conjugated to lectins from Schinus terebinthifolia leaves (SteLL) and Punica granatum	4
Mandarin peel ethanolic extract attenuates diclofenac sodium induced hepatorenal toxicity in rats by mitigating oxidative stress and inflammation	4
Impact of benzophenone-2 exposure on the reproductive outcomes in adult female mice	4
Hydromorphone impurity 2,2-bishydromorphone does not exert mutagenic and clastogenic properties via in silico QSAR prediction and in vitro Ames and micronucleus test	4
The effect of preconditioning agents on cardiotoxicity and neurotoxicity of carbon monoxide poisoning in animal studies: a systematic review	4
Hepatoprotective effect of methanol fruit extract of Punica granatum L in highly active antiretroviral therapy-induced toxicity in Wistar rats	4
Investigating the impact of external application of formalin and potassium permanganate on hematological, immunological, and biochemical profiles in Labeo rohita fingerl	4
Assessment of cardiotoxicity induced by PFOS exposure and mechanism research via untarget metabolomics	4
Protective effects of royal jelly and Echinacea against moxifloxacin-induced renal and hepatic injury in rats	4
Acute and subacute dermal toxicity analysis of film forming topical spray of meloxicam: in vitro and in vivo studies	4
Protective effects of a chemically characterized extract fromsolanum torvumleaves on acetaminophen-induced liver injury	4
Synergistic hepatoprotection by supplementing Saussurea costus (falc.) lipsch and Glycyrrhiza glabra L. in combination against Diethylnitr	4
In vitro screening of genotoxicity and mutagenicity of pyriproxyfen in human lymphocytes and Salmonella typhimurium TA98 and TA100 strains	4
Acute exposure to environmentally relevant concentrations of pharmaceutical pollutants induces neurobehavioral toxicity in zebrafish ( Danio rerio )	4