OOIR: Observatory of International Research

Papers

(The TQCC of Drug and Chemical Toxicology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Chemical characterization of tobacco-free “modern” oral nicotine pouches and their position on the toxicant and risk continuums	45
Formaldehyde toxicity reports from in vitro and in vivo studies: a review and updated data	37
Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats	21
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish	21
Evaluation of genotoxicity induced by herbicide pendimethalin in fresh water fish Clarias batrachus (linn.) and possible role of oxidative stress in induced DNA damage	19
In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy	18
The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis	18
Characterization and neuroprotective properties of alkaloid extract of Vernonia amygdalina Delile in experimental models of Alzheimer’s disease	18
Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress	17
Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage	17
Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin-A in isoproterenol-induced myocardial infarction in rats	17
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats	16
Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats	16
Protection of CCl₄-induced hepatic and renal damage by linalool	15
Benzo(a)pyrene affects proliferation with reference to metabolic genes and ROS/HIF-1α/HO-1 signaling in A549 and MCF-7 cancer cells	15
Hepatoprotective effect of Raspberry ketone and white tea against acrylamide-induced toxicity in rats	15
Selenium and L-carnitine protects from valproic acid-Induced oxidative stress and mitochondrial damages in rat cortical neurons	15
Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis	15
The comparison of the effect of Origanum vulgare L. extract and vitamin C on the gentamycin-induced nephrotoxicity in rats	14
Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat	14
A comparison of cell death mechanisms of antioxidants, butylated hydroxyanisole and butylated hydroxytoluene	13
The outbreak of methanol intoxication during COVID-19 pandemic: prevalence of brain lesions and its predisposing factors	13
Borassus flabellifer haustorium extract prevents pro-oxidant mediated cell death and LPS-induced inflammation	13
Acute toxic effects of chlorpyrifos on pseudobranchial neurosecretory system, brain regions and locomotory behavior of an air-breathing catfish, Heteropneustes fossilis (Bloch 1794)	13
Miconazole and terbinafine induced reactive oxygen species accumulation and topical toxicity in human keratinocytes	13

Shaddock (Citrus maxima) peels extract restores cognitive function, cholinergic and purinergic enzyme systems in scopolamine-induced amnesic rats	13
Ellagic acid alleviates clozapine‑induced oxidative stress and mitochondrial dysfunction in cardiomyocytes	12
L-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, Cyt c and CASP-3 signaling	12
Linalool reverses benzene-induced cytotoxicity, oxidative stress and lysosomal/mitochondrial damages in human lymphocytes	12
Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells	12
Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress	12
Brazil nut prevents oxidative DNA damage in type 2 diabetes patients	12
Evaluation of the acute toxic effect of azoxystrobin on non-target crayfish (Astacus leptodactylus Eschscholtz, 1823) by using oxidative stress enzymes, ATPases and cholinesterase as biomarkers	12
Placental levels of polycyclic aromatic hydrocarbons (PAHs) and their association with birth weight of infants	12
Mechanism of phthalate esters in the progression and development of breast cancer	12
The protective effect of fluted pumpkin seeds against atrazine-induced testicular injury	12
The protective effects of vitamins A, C, and E on zinc oxide nanoparticles (ZnO NPs)-induced liver oxidative stress in male Wistar rats	11
Acute and subchronic toxicity studies of rhein in immature and d-galactose-induced aged mice and its potential hepatotoxicity mechanisms	11
Effect of carnosic acid on acrylamide induced neurotoxicity: in vivo and in vitro experiments	11
Risk assessment of elevated blood lead concentrations in the adult population using a decision tree approach	11
Role of aluminum exposure on Alzheimer’s disease and related glycogen synthase kinase pathway	11
Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity	11
Alogliptin attenuates cyclophosphamide-induced nephrotoxicity: a novel therapeutic approach through modulating MAP3K/JNK/SMAD3 signaling cascade	10
Effects of ellagic acid in the testes of streptozotocin induced diabetic rats	10
The effect of sulfamethoxazole on oxidative stress indices in zebrafish (Danio rerio)	10
Neurotoxicity of poly(propylene imine) glycodendrimers	10
Health risk assessment of 42 pesticide residues in Tieguanyin tea from Fujian, China	9
Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis	9
Cytogenetic effects of antidiabetic drug metformin	9
Salvianolic acid A suppresses CCl₄-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways	9
Effects of burnt tire-ash on Na⁺/K⁺, Ca²⁺-ATPase, serum immunoglobulin and brain acetylcholinesterase activities in clarias gariepinus (Burchell, 1822)	9
Antiandrogen enzalutamide induced genetic, cellular, and hepatic damages: amelioration by triterpene Lupeol	9
Effects of acrylamide on protein degradation pathways in human liver-derived cells and the efficacy of N-acetylcysteine and curcumin	9
The genotoxic effects of mixture of aluminum, arsenic, cadmium, cobalt, and chromium on the gill tissue of adult zebrafish (Danio rerio, Hamilton 1822)	9
Investigation of the genotoxic effects of patent blue V (E131) in human peripheral lymphocytes and in silico molecular docking	9
The impact of filtered water-pipe smoke on healthy versus cancer cells and their neurodegenerative role on AMPA receptor	9
The role of ginger’s extract and N-acetylcysteine against docetaxel-induced oxidative stress and genetic disorder	9
Tucumã (Astrocaryum aculeatum) extract: phytochemical characterization, acute and subacute oral toxicity studies inWistarrats	8
Safety and biological activity evaluation of Uncaria rhynchophylla ethanolic extract	8
Protective effects of p-coumaric acid against gentamicin-induced nephrotoxicity in rats	8
Evidence of drug-induced hepatotoxicity in the Maghrebian population	8
Evaluation of the toxicological effects of favipiravir (T-705) on liver and kidney in rats: biochemical and histopathological approach	8
Protective effects of extracts of lichen Dirinaria consimilis (Stirton) D.D. Awasthi in bifenthrin- and diazinon-induced oxidative stress in rat erythrocytes in vitro	8
Co-drug of isoniazid and sulfur containing antioxidant for attenuation of hepatotoxicity and treatment of tuberculosis	8
Hepatoprotective effect of seabuckthorn leaf-extract in lead acetate-intoxicated Wistar rats	8
Immunotoxic effects of force-fed ethephon on model organism Galleria mellonella (Lepidoptera: Pyralidae)	8
Sub-chronic and chronic toxicity evaluation of 7-methylxanthine: a new molecule for the treatment of myopia	8
The protective effect of herniarin on genotoxicity and apoptosis induced by cisplatin in bone marrow cells of rats	8
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice	8
Therapeutic effects of thymoquinone or capsaicin on acrylamide-induced reproductive toxicity in rats mediated by their effect on oxidative stress, inflammation, and tight junction integrity	8
Neuromodulatory and oxidative stress evaluations in African catfish Clarias gariepinus exposed to antipsychotic drug chlorpromazine	8
l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson’s disease	8
Microplastic-induced oxidative stress response in turbot and potential intake by humans	7
Centella asiatica prevents D-galactose-Induced cognitive deficits, oxidative stress and neurodegeneration in the adult rat brain	7
Cocoyam (Colocasia esculenta) modulates some parameters of testosterone propionate-induced rat model of benign prostatic hyperplasia	7

Ochratoxin a in breast milk in Morocco: the affecting dietary habits of the lactating mothers and the degree of exposure of newborns “CONTAMILK study”	7
Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats	7
Borassus flabellifer Linn haustorium methanol extract mitigates fluoride-induced apoptosis by enhancing Nrf2/Haeme oxygenase 1 –dependent glutathione metabolism in intestinal epithelial cells	7
Tempol (4-hydroxy tempo) protects mice from cisplatin-induced acute kidney injury via modulation of expression of aquaporins and kidney injury molecule-1	7
The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury	7
Toxicity of the herbicides used on herbicide-tolerant crops, and societal consequences of their use in France	7
MicroRNA as an early diagnostic biomarker for contrast-induced acute kidney injury	7
Morel mushroom, Morchella from Kashmir Himalaya: a potential source of therapeutically useful bioactives that possess free radical scavenging, anti-inflammatory, and arthritic edema-inhibiting	7
Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP	7
Enhanced fluorescent sensing probe via PbS quantum dots functionalized with gelatin for sensitive determination of toxic bentazon in water samples	7
Neurotoxic responses of rainbow trout (Oncorhynchus mykiss) exposed to fipronil: multi-biomarker approach to illuminate the mechanism in brain	7
PM_2.5from diesel exhaust attenuated fisetin mediated cytoprotection in H9c2 cardiomyocytes subjected to ischemia reoxygenation by inducing mitotoxicity	7
Protective effects of resveratrol and avocado oil against paracetamol-induced hepatotoxicity in rats	7
Exacerbation of diclofenac-induced gastroenterohepatic damage by concomitant exposure to sodium fluoride in rats: protective role of luteolin	7
Ameliorative effects of hexane extract of Garcinia kola seeds Heckel (Clusiaceae) in cisplatin-induced hepatorenal toxicity in mice	7
Subacute oral toxicology and toxicokinetics of pterostilbene, a novel Top1/Tdp1 inhibiting anti-tumor reagent	7
Acute organophosphate and carbamate pesticide poisonings – a five-year survey from the National Poison Control Center Of Serbia	7
Azithromycin effects on the European sea bass (Dicentrarchus labrax) early life stages following acute and chronic exposure: Laboratory bioassays	7
Modulating effect of a hydroxychalcone and a novel coumarin–chalcone hybrid against mitomycin-induced genotoxicity in somatic cells of Drosophila melanogaster	7
Psoralen induces liver injuries through endoplasmic reticulum stress signaling in female mice	7
Quercetin alleviates styrene oxide-induced cytotoxicity in cortical neurons in vitro via modulation of oxidative stress and apoptosis	7
3,4-Dihydroxybenzaldehyde attenuates pentachlorophenol-induced cytotoxicity, DNA damage and collapse of mitochondrial membrane potential in isolated human blood cells	6
Involvement of oxidative stress and toll-like receptor-4 signaling pathways in gentamicin-induced nephrotoxicity in male Sprague Dawley rats	6
The protective effect of rutin against busulfan-induced testicular damage in adult rats	6
Protocatechuic acid protects against hepatorenal toxicities in rats exposed to Furan	6
Nano-titanium nitride causes developmental toxicity in zebrafish through oxidative stress	6
Decision tree algorithm can determine the outcome of repeated supratherapeutic ingestion (RSTI) exposure to acetaminophen: review of 4500 national poison data system cases	6
Antioxidant, antinociceptive, anti-inflammatory, and hepatoprotective activities of pentacyclic triterpenes isolated from Ziziphus oxyphylla Edgew	6
Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum	6
Alpha-mangostin attenuates the apoptotic pathway of abamectin in the fetal rats’ brain by targeting pro-oxidant stimulus, catecholaminergic neurotransmitters, and transcriptional regulation of reelin	6
Gallic acid ameliorates busulfan-induced testicular toxicity and damage in mature rats	6
In silico QSAR modeling to predict the safe use of antibiotics during pregnancy	6
Preventive treatment with sodium para-aminosalicylic acid inhibits manganese-induced apoptosis and inflammation via the MAPK pathway in rat thalamus	6
Lead and lead–arsenic combined exposure induces mortality and developmental impairments in zebrafish embryos: a study using wild-caught zebrafish from Bangladesh	5
Protective effect of Thymus munbyanus aqueous extract against 2,4-dichlorophenoxyacetic acid-induced nephrotoxicity in Wistar rats	5
Ixazomib-associated cardiovascular adverse events in multiple myeloma: a systematic review and meta-analysis	5
Effects of prolonged subchronic benzo(α)pyrene exposure on rat liver morphology and CYP1A expression during treatment with menadione, quercetin, or tocopherol	5
Evaluation of oxidative stress biomarkers and liver and renal functional parameters in patients during treatment a mental health unit to treat alcohol dependence	5
Ameliorative role of inducible nitric oxide synthase inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats	5
Toxicological assessment of electronic cigarette vaping: an emerging threat to force health, readiness and resilience in the U.S. Army	5
The effect of melatonin on testis histological changes and spermatogenesis indexes in mice following treatment with dexamethasone	5
Febuxostat, an inhibitor of xanthine oxidase, ameliorates ionizing radiation-induced lung injury by suppressing caspase-3, oxidative stress and NF-κB	5
Investigation of the effects of three different generations of fluoroquinolone derivatives on antioxidant and immunotoxic enzyme levels in different rat tissues	5
Investigation of protective effect of ellagic acid in phthalates-induced reproductive damage	5
Trends of acute drug and chemical toxicities in adults and adolescents in Tehran, Iran between 2012 and 2018: a retrospective chart review	5
Nebivolol alleviates liver damage caused by methotrexate via AKT1/Hif1α/eNOS signaling	5
Betaine attenuates sodium arsenite-induced renal dysfunction in rats	5
Subacute toxicity study of the ethanolic extract of Mesua ferrea (L.) flowers in rats	5
Enniatin B induces dosage-related apoptosis or necrosis in mouse blastocysts leading to deleterious effects on embryo development	5
Exposure to pyrethroids induces behavioral impairments, neurofibrillary tangles and tau pathology in Alzheimer’s type neurodegeneration in adult Wistar rats	5
D-ribose-L-cysteine modulates lead acetate-induced hematobiochemical alterations, hormonal imbalance, and ovarian toxicity in adult female Wistar rats	5
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate	5
Rutin ameliorates perfluorooctanoic acid-induced testicular injury in mice by reducing oxidative stress and improving lipid metabolism	5
Long-term toxicity of fluoroquinolones: a comprehensive review	5
Phytochemical evaluation of Cucumis prophetarum: protective effects against carrageenan-induced prostatitis in rats	5
Verbascoside inhibits paraquate-induced pulmonary toxicity via modulating oxidative stress, inflammation, apoptosis and DNA damage in A549 cell	5