OOIR: Observatory of International Research

Papers

(The TQCC of Drug and Chemical Toxicology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea	67
Cytotoxic effect and induction of apoptosis in human cervical cancer cells by a wood extract from Prosopis laevigata	20
Comparative study of the genotoxic activity of Artemisia vulgaris L. and Artemisia alba Turra extracts in vitro	20
Tinospora Cordifolia and Arabinogalactan in combination modulates benzo(a)pyrene-induced genotoxicity during lung carcinogenesis	20
Novel chlorinated oxime K870 protects rats against paraoxon poisoning better than obidoxime	18
Livogrit prevents Amiodarone-induced toxicity in experimental model of human liver (HepG2) cells and Caenorhabditis elegans by regulating redox homeostasis	16
Computational and experimental study of terpolymers: spectroscopic, thermal, thermochemical, molecular property, and in silico toxicity analysis	15
Dichlorophene activates aryl hydrocarbon receptor (AhR) and indoleamine 2, 3-dioxygenase 1 (IDO1) to mediate splenotoxicity in rat	15
Antioxidant capacity, acute and sub-acute oral toxicity, and in vivo anti-inflammatory effects of Tetradenia riparia hydroalcoholic extrac	15
Assessment of cardiotoxicity induced by PFOS exposure and mechanism research via untarget metabolomics	14
Gastroprotective mechanism of Talinum triangulare on ethanol-induced gastric ulcer in Wistar rats via inflammatory, antioxidant, and H	14
Toxicity optimization of green zinc oxide quantum dots in zebrafish using Box-Behnken design: a novel approach for safer nanoparticle synthesis	13
Long-term exposure to bisphenol-A causes oxidative stress-related alterations at the genetic and cellular levels in the mature ovary of adult zebrafish	13
Investigation of the role of K _ATP channels in the cytotoxic effect of cypermethrin on rat-derived aortic smooth muscle cells	12
Investigating the impact of external application of formalin and potassium permanganate on hematological, immunological, and biochemical profiles in Labeo rohita fingerl	12
The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity	12
Sweet basil ( Ocimum basilicum ) leaf and seed extracts alleviate neuronal dysfunction in aluminum chloride-induced neurotoxicity in Drosophila melanogast	11
Eight-year epidemiological study for drug poisoning in Qassim, Saudi Arabia, 2008–2015	11
Oxidative stress and inflammatory markers in streptozotocin-induced acute and subacute toxicity response	11
Protective role of resveratrol and apigenin against toxic effects of bisphenol a in rat salivary gland	11
Quercetin prevents methylmercury-induced mitochondrial dysfunction in the cerebral cortex of mice	11
Omeprazole induces profibrotic gene expression in rat kidney: implication of TGF-β/Smad signaling pathway	10
Unraveling the hepatoprotective and anti-pancreatic cancer potential of Caralluma europaea : a comprehensive in vivo, in vitro and in sili	10
In vitro assessment of the antioxidative, toxicological and antimicrobial properties of battery of parabens	10
Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum)extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model	10

Hepatic histopathological and morphometric changes in male mice exposed to rosuvastatin from pre-puberty to adulthood: a possible adaptive hepatic response	10
Effects of electrospun fiber curcumin on bisphenol A exposed Caco-2 cells	10
Genotoxic effects of gadobutrol and gadoversetamide active substances used in magnetic resonance imaging in human peripheral lymphocytesin vitro	10
Neuroprotective effects of fermented blueberry and black rice against particulate matter 2.5 μm-induced inflammation in vitro and in vivo	10
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice	10
Determination of histopathological effects and myoglobin, periostin gene-protein expression levels in Danio rerio muscle tissue after acaricide yoksorrun-5EC (hexythiazox) application	10
Evaluation of genotoxic and mitotoxic effects of TAF-loaded chitosan nanoparticles in HepG2 cells	10
Neurotoxic effects of carbamazepine on the mosquitofish Gambusia affinis	10
Aprepitant mitigates paclitaxel-induced neuropathic pain in rats via suppressing inflammatory pathways in dorsal root ganglia	10
Acute, repeated inhalation toxicity, respiratory system irritation, and mutagenicity studies of 1,1,2,2-tetrafluoroethane (HFC-134) as the impurity in the pharmaceutical propellant 1,1,1,2-tetrafluoro	10
The protective effects of capsaicin on oxidative damage-induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats	10
Effect of chlorpyrifos on some biochemical changes in Cyprinus carpio: the protective effect of ellagic acid	9
Topiramate’s effects on normal and fatty liver	9
Exposure to emamectin benzoate confers cytotoxic effects on human molt-4 T-cells and possible ameliorative role of vitamin E and dithiothreitol	9
Amelioration of metabolic disorders in H9C2 cardiomyocytes induced by PM _2.5 treated with vitamin C	9
Alpha-mangostin attenuates the apoptotic pathway of abamectin in the fetal rats’ brain by targeting pro-oxidant stimulus, catecholaminergic neurotransmitters, and transcriptional regulation of reelin	9
The protective effect of N-acetyl cysteine against selenium toxicity and gamma irradiation in rats	9
Is a non-cytotoxic and non-genotoxic novel bioinspired dipeptide structure synthesis possible for theragnostic applications?	8
Changes in hormones, Leukocyte Telomere Length (LTL), and p16^INK4a expression in SM-exposed individuals in favor of the cellular senescence	8
The role of ginger’s extract and N-acetylcysteine against docetaxel-induced oxidative stress and genetic disorder	8
Non-permitted food colorants induced neurotoxicity in cerebellum of rat brain	8
Hepatoprotective effects of norgalanthamine on carbon tetrachloride induced-hepatotoxicity in mice	8
Anticonvulsant effectiveness of scopolamine against soman-induced seizures in African green monkeys	8
Investigation of genotoxic effects of rhododendron honey using three mammalian bioassays in vivo	7
Silver nanoparticles’ impact on the gene expression of the cytosolic adaptor MyD-88 and the interferon regulatory factor IRF in the gills and digestive gland of mytilus galloprovinciali	7
Resveratrol-mediated cardioprotection against myocardial ischemia-reperfusion injury was revoked by statin-induced mitochondrial alterations	7
Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats	7
N ^ω -nitro-L-arginine, a nitric oxide synthase inhibitor, attenuates nickel-induced neurotoxicity	7
Population pharmacokinetics and pharmacodynamics of L-asparaginase and its impact on the development of pancreatitis and hypersensitivity reactions in children with leukemia under treatment	6
Apoptosis is involved in paraoxon-induced histological changes in rat cerebellum	6
The effects of minocycline in improving of methamphetamine withdrawal syndrome in male mice	6
Taurine and enzymatically modified isoquercitrin synergistically protect against the methotrexate-induced cardiotoxicity in rats: antioxidant and antiapoptotic effects	6
In vitro evaluation of the selective cytotoxicity and genotoxicity of three synthetic ortho -nitrobenzyl derivatives in human cancer cell lines, with	6
Comparative toxicological evaluation of carvacrol, acetylcarvacrol anda fipronil-based pesticide in human blood cells	6
In silico and in vivo protective effect of Morus nigra leaves on oxidative damage induced by iron overload	6
Furan impairs cell function by inducing oxidative stress, DNA damage and apoptosis in mouse Sertoli cells in vitro	6
Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems	6
The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells	6
Protective effects of resveratrol and avocado oil against paracetamol-induced hepatotoxicity in rats	6
A toxicological review of alkaloids	6
Toxicological evaluation of ethanolic extract of leaves from Doliocarpus dentatus in Swiss mice	6
Formulation and evaluation of solid lipid nanoparticles loaded with papaya seed chloroform extract for long-term antifertility effects on the male rat, Bandicota bengalensis	6
Evaluating the therapeutic effect and toxicity of theophylline in infertile men with asthenoteratozoospermia: a double-blind, randomized clinical trial study	6
Rosuvastatin exposure in female Wistar rats alters uterine contractility and do not show evident (anti)estrogenic effects	5
Bromelain protects against cisplatin-induced ocular toxicity through mitigating oxidative stress and inflammation	5
Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells	5
Cadmium and ketoprofen accumulation influences aquatic ecosystem demonstrated using in-vivo zebrafish model	5
Neuroprotective effects of gastrodin against bisphenol A induced-ADHD-like symptoms in rats	5
Perfluorooctane sulfonate (PFOS) triggers migration and invasion of esophageal squamous cell carcinoma cells via regulation of Zeb1	5
Evaluation of acute and subacute dermal toxicity of antibacterial bioactive glass-infused surgical cotton gauze in Wistar rats	5

Interactive effect of carbendazim and imidacloprid on buffalo bone marrow derived mesenchymal stem cells: oxidative stress, cytotoxicity and genotoxicity	5
Correction	5
Opioid poisoning cases aged 50+ in the 2015–2020 National Poisoning Data System: suspected suicides versus unintentional poisoning and other intentional misuse/abuse	5
Amelioration of modified chronic unpredictable stress usingCelastrus paniculatusseed oil alone and in combination with fluoxetine	5
Fluvastatin alleviates doxorubicin-induced cardiac and renal toxicity in rats via regulation of oxidative stress, inflammation, and apoptosis associated genes expressions	5
Implications of atrazine concentrations in drinking water from Ijebu-North, Southwest Nigeria on the hypothalamic-pituitary-adrenal axis	5
Effects of ellagic acid in the testes of streptozotocin induced diabetic rats	5
Genotoxic and genoprotective effects of phytoestrogens: a systematic review	5
Piribedil and thymol mitigate vancomycin-evoked nephrotoxicity in rats through modulation of Keap-1/Nrf2/HO-1 and NF-κB/Bax/caspase 3 signalings	5
PM_2.5from diesel exhaust attenuated fisetin mediated cytoprotection in H9c2 cardiomyocytes subjected to ischemia reoxygenation by inducing mitotoxicity	5
The inhibitory effects of pimozide, an antipsychotic drug, on voltage-gated K⁺ channels in rabbit coronary arterial smooth muscle cells	5
Assessment of Toxicity and Wound Healing Activity of Selaginella Bryopteris Extract	4
Unraveling the neuroprotective mechanisms of naltrexone against aluminum-induced neurotoxicity	4
Anti-ischemic drug trimetazidine blocks mercury nephrotoxicity by suppressing renal redox imbalance, inflammatory stress and caspase-dependent apoptosis in rats	4
Outcome prediction of methadone poisoning in the United States: implications of machine learning in the National Poison Data System (NPDS)	4
Effects of low-dose ionizing radiation on the molecular pathways linking neurogenesis and autism spectrum disorders in zebrafish embryos	4
Phytochemical composition, cytotoxicity, antioxidant and antimicrobial responses of Lavandula dentata L. grown under different levels of heavy metals stress condition	4
Should combined MTX and CoQ10 use be reconsidered in terms of steatosis? A biochemical, flow cytometry, histopathological experimental study	4
Toxicity of pesticide cocktails in amphibian larvae: understanding the impact of agricultural activity on aquatic ecosystems in the Salado River basin, Argentina	4
Assessing chromium toxicity across aquatic and terrestrial environments: a cross-species review	4
Correction	4
Atrazine residue in waters of Ijebu-North local government, Nigeria: implications on human health, hematological, and biochemical parameters	4
Determination of micronuclei frequency in Danio rerio for assessing genotoxicity induced by propineb	4
Lagerstroemia speciosa (L.) Pers., ethanolic leaves extract attenuates dapsone-induced liver inflammation in rats	4
Cytogenetic damage by vanadium(IV) and vanadium(III) on the bone marrow of mice	4
Invisible enemies: evaluating human health threats of mosquito repellents through animal studies	4
Manganese mitigates against hepatorenal oxidative stress, inflammation and caspase-3 activation in rats exposed to hexachlorobenzene	4
Tauroursodeoxycholic acid suppresses biliary epithelial cell apoptosis and endoplasmic reticulum stress by miR-107/NCK1 axis in a FXR-dependent manner	4
Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats	4
Exploring the toxicity profile of coriander ( C. sativum L.) essential oil: implications for translational toxicological research	4
Two cases report of febuxostat-induced acute liver injury: acute heart failure as a probable risk factor?	4
Antibiotic sorption onto MPs in terrestrial environment: a critical review of the transport, bioaccumulation, ecotoxicological effects and prospects	4
Protective effect of neurotensin receptor-1 agonist PD 149163 against lipopolysaccharide-induced gut toxicity in mice	4
Cytotoxicity of methamphetamine exposure on Sertoli cells: a pilot study with implications for male infertility	4
Repeated dose toxicity studies of Trichostatin A in Swiss albino mice through oral and intravenous route of administration with special emphasis on genotoxicity	4