Drug and Chemical Toxicology

Papers
(The TQCC of Drug and Chemical Toxicology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)
ArticleCitations
Evaluating the therapeutic effect and toxicity of theophylline in infertile men with asthenoteratozoospermia: a double-blind, randomized clinical trial study26
Toxicological evaluation of ethanolic extract of leaves from Doliocarpus dentatus in Swiss mice21
Opioid poisoning cases aged 50+ in the 2015–2020 National Poisoning Data System: suspected suicides versus unintentional poisoning and other intentional misuse/abuse19
In vitro evaluation of the selective cytotoxicity and genotoxicity of three synthetic ortho -nitrobenzyl derivatives in human cancer cell lines, with 19
Gastroprotective mechanism of Talinum triangulare on ethanol-induced gastric ulcer in Wistar rats via inflammatory, antioxidant, and H 16
Unraveling the hepatoprotective and anti-pancreatic cancer potential of Caralluma europaea : a comprehensive in vivo, in vitro and in sili16
Antioxidant capacity, acute and sub-acute oral toxicity, and in vivo anti-inflammatory effects of Tetradenia riparia hydroalcoholic extrac16
Dichlorophene activates aryl hydrocarbon receptor (AhR) and indoleamine 2, 3-dioxygenase 1 (IDO1) to mediate splenotoxicity in rat16
Oxidative stress and inflammatory markers in streptozotocin-induced acute and subacute toxicity response15
The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity15
Investigation of the role of K ATP channels in the cytotoxic effect of cypermethrin on rat-derived aortic smooth muscle cells15
Tinospora Cordifolia and Arabinogalactan in combination modulates benzo(a)pyrene-induced genotoxicity during lung carcinogenesis14
Non-permitted food colorants induced neurotoxicity in cerebellum of rat brain14
Effect of chlorpyrifos on some biochemical changes in Cyprinus carpio: the protective effect of ellagic acid14
Amelioration of metabolic disorders in H9C2 cardiomyocytes induced by PM 2.5 treated with vitamin C14
Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum)extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model13
Investigation of oxidative, inflammatory and apoptotic effects of favipiravir use alone and combined with vitamin C on brain tissue of elderly rats12
Changes in hormones, Leukocyte Telomere Length (LTL), and p16INK4a expression in SM-exposed individuals in favor of the cellular senescence12
Silymarin attenuates cobalt chloride-induced redox imbalance and cardio-renal dysfunctions in rats12
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea12
Genotoxic effects of gadobutrol and gadoversetamide active substances used in magnetic resonance imaging in human peripheral lymphocytesin vitro12
Pelargonidin ameliorates reserpine-induced neuronal mitochondrial dysfunction and apoptotic cascade: a comparative in vivo study12
Population pharmacokinetics and pharmacodynamics of L-asparaginase and its impact on the development of pancreatitis and hypersensitivity reactions in children with leukemia under treatment12
Manganese mitigates against hepatorenal oxidative stress, inflammation and caspase-3 activation in rats exposed to hexachlorobenzene12
Assessment of morin hydrate as a renal protective agent in rats subjected to methotrexate-induced nephrotoxicity11
Evaluation of acute and 28-day repeated dose toxicity of Tolypocladium sinense soft capsule in Sprague-Dawley rats11
NO-mediated DNA damage induced by polystyrene nanoparticles triggers program cell death in mesenchymal stem cells11
Toxicity of pesticide cocktails in amphibian larvae: understanding the impact of agricultural activity on aquatic ecosystems in the Salado River basin, Argentina11
MiADMSA abrogates sodium tungstate-induced oxidative stress in rats10
Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats10
Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations in zebrafish10
Content of potentially toxic elements (PTEs) in coffee and coffee-based products: a meta-analysis study, Systematic review, and health risk assessment10
Synergistic hepatoprotective effects of ω-3 and ω-6 fatty acids from Indian flax and sesame seed oils against CCl 4 -induced oxidative stress-mediated liver damage i10
Tauroursodeoxycholic acid suppresses biliary epithelial cell apoptosis and endoplasmic reticulum stress by miR-107/NCK1 axis in a FXR-dependent manner10
Renal tubular response to titanium dioxide nanoparticles exposure10
Linolenic acid stimulates eryptosis and hemolysis through oxidative stress and CK1α/MLKL: protective role of melatonin, urea, and polyethylene glycol10
Screening and toxicity evaluation of natural compounds as adenosine 2a and 2b receptor ligands: insights from molecular docking, dynamics, and ADMET analysis10
Protective effect of neurotensin receptor-1 agonist PD 149163 against lipopolysaccharide-induced gut toxicity in mice10
Fumaric acid protects rats from ciprofloxacin-provoked depression through modulating TLR4, Nrf-2, and p190-rho GTP9
Toxicity study of compound honeysuckle moisturizing Chinese herbal extract by oral gavage for 13 weeks in sprague dawley rats9
Modulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells9
Antioxidant and in vitro cytogenotoxic properties of Amburana cearensis (Allemão) A.C.Sm. leaf extract9
Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats9
Toothpastes for children and their detergent contents affect molecular mechanisms of odontogenesis in zebrafish embryos9
Probiotics modulation of the endotoxemic effect on the gut and liver of the lipopolysaccharide challenged mice9
Single acute and repeated subacute toxicity evaluations of Annona atemoya leaf extract with in vitro anti-inflammatory potential8
TiO 2 nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish ( Danio8
Cyclosporine-A induced cytotoxicity within HepG2 cells by inhibiting PXR mediated CYP3A4/CYP3A5/MRP2 pathway8
Preventive treatment with sodium para-aminosalicylic acid inhibits manganese-induced apoptosis and inflammation via the MAPK pathway in rat thalamus8
Damage to the sarcoplasmic reticulum by venom of the Mexican black-tailed rattlesnake ( Crotalus molossus nigrescens ): inhibition of the Ca 2+ 8
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway8
Naringenin mitigates cadmium-induced cell death, oxidative stress, mitochondrial dysfunction, and inflammation in KGN cells by regulating the expression of sirtuin-18
Effect of adenosine triphosphate on methylphenidate-induced oxidative and inflammatory kidney damage in rats8
Long term integrated biomarker responses in freshwater African catfish Clarias gariepinus exposed to a new brand of herbicide fluazifop-p-butyl7
Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats7
Assessment of the toxicity of different antiretroviral drugs and their combinations on Sertoli and Leydig cells7
Safety assessment of Wuzhuyu decoction extract: acute and subacute oral toxicity studies in rats7
Pentoxifylline inhibits phosgene-induced lung injury via improving hypoxia7
Prognostic value of systemic immune-inflammation index and monocyte-to-HDL-cholesterol ratio in early cardio-cerebral complications in elderly patients with acute severe carbon monoxide poisoning7
Toxicological assays in the evaluation of safety assessment of fibrinolytic enzymes7
Study on the acute and subchronic oral toxicity of Calculus Bovis Sativus in rats7
Assessment of the effect of sodium tetraborate on oxidative stress, inflammation, and apoptosis in lead-induced nephrotoxicity7
B-Raf inhibitor vemurafenib counteracts sulfur mustard-induced epidermal impairment through MAPK/ERK signaling7
Chronic bisphenol A exposure induces temporal neurobehavioral transformation and augmented chromatin condensation in the periventricular gray zone of zebrafish brain6
Fluoroquinolone antibiotics in the aquatic environment: environmental distribution, the research status and eco-toxicity6
The protective effect of chrysin against oxidative stress and organ toxicity in rats exposed to propetamphos6
Protective effects ofp-coumaric acid against gentamicin-induced nephrotoxicity in rats6
Computational modeling ( in silico ) methods combined with ecotoxicological experiments ( in vivo ) to predict the environmental risks of 6
In vitro antibacterial and anti-inflammatory effects of Anacardium occidentale L. extracts and their toxicity on PBMCs and zebrafish embryos6
Uncoupling as initiating event in mitochondrial dysfunction after diuron exposure6
Effect ofMoringa oleiferaleaf extract on valproate-induced oxidative damage in muscle6
Both acute glyphosate and the aminomethylphosphonic acid intoxication decreased the acetylcholinesterase activity in rat hippocampus, prefrontal cortex and gastrocnemius muscle6
Comparative cytotoxicity induced by parabens and their halogenated byproducts in human and fish cell lines6
Electronic cigarette aerosol increases the risk of organ dysfunction by enhancing oxidative stress and inflammation6
Involvement of oxidative stress and toll-like receptor-4 signaling pathways in gentamicin-induced nephrotoxicity in male Sprague Dawley rats6
Pre-clinical and cellular safety assessment of oral administered DHA rich microalgae oil from Schizochytrium sp. (Strain ATCC-20889): acute, sub-chronic and genotoxicity6
Chronic levamisole exposure in male rats alters sexual behavior and induces apoptosis in the testis6
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats6
Phycocyanin improved alcohol-induced hepatorenal toxicity and behavior impairment in Wistar rats6
Nigella sativa oil reduces oxidative/nitrosative stress in the salivary gland of rats exposed to total cranial irradiation6
Salvianolic acid A suppresses CCl4-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways5
Phytochemical composition, cytotoxicity, antioxidant and antimicrobial responses of Lavandula dentata L. grown under different levels of heavy metals stress condition5
Omeprazole induces profibrotic gene expression in rat kidney: implication of TGF-β/Smad signaling pathway5
Single and repeat-dose toxicity and local tolerance assessment of newly developed oil emulsion adjuvant formulations for veterinary purposes5
Exploring the toxicity profile of coriander ( C. sativum L.) essential oil: implications for translational toxicological research5
A study on Wistar Albino rats: investigating protective role of ramelteon on liver damage caused by methotrexate5
In vitro and in vivo genotoxicity assessments of Ficus erecta Thunb. leaves extract support its functional and pharmace5
Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos5
Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems5
Acute and 13 weeks subchronic toxicological evaluation of the flavonoid-rich extract of Sophora flavescens5
MiR-27b-3p ameliorates DOX-induced cardiotoxicity by suppressing myocardial inflammation and oxidative stress in mice and cardiomyocytes5
A comparison of the potential of melatonin and tryptophan to ameliorate CCl 4 -induced hepatic and renal toxicity in Wistar rats5
Ameliorative effects of nutritional minerals on lead-induced hematological alterations in male Wistar albino rats5
Therapeutic effects of thymoquinone or capsaicin on acrylamide-induced reproductive toxicity in rats mediated by their effect on oxidative stress, inflammation, and tight junction integrity5
Genotoxic and genoprotective effects of phytoestrogens: a systematic review5
Evaluation of XQ528 tartrate on embryo-fetus developmental toxicity in SD rats and genotoxicity5
Eight-year epidemiological study for drug poisoning in Qassim, Saudi Arabia, 2008–20155
Potential neuroprotective effects of 2-hydroxypropyl-β cyclodextrin against amyloid β (1-42)-induced neurotoxicity on the rat hippocampus5
Protective effects of perindopril against indomethacin-induced gastric mucosal damage through modulation of DDAH-1/ADMA and ACE-2/ANG-(1-7) signaling pathways4
Hydromorphone impurity 2,2-bishydromorphone does not exert mutagenic and clastogenic properties via in silico QSAR prediction and in vitro Ames and micronucleus test4
Evaluation of antifungal activity, mechanisms of action and toxicological profile of the synthetic amide 2-chloro- N -phenylacetamide4
A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine4
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats4
Hepatoprotective effect of methanol fruit extract of Punica granatum L in highly active antiretroviral therapy-induced toxicity in Wistar rats4
Mandarin peel ethanolic extract attenuates diclofenac sodium induced hepatorenal toxicity in rats by mitigating oxidative stress and inflammation4
Protective effects of a chemically characterized extract fromsolanum torvumleaves on acetaminophen-induced liver injury4
Correction4
Acute exposure to environmentally relevant concentrations of pharmaceutical pollutants induces neurobehavioral toxicity in zebrafish ( Danio rerio )4
Effects of burnt tire-ash on Na+/K+, Ca2+-ATPase, serum immunoglobulin and brain acetylcholinesterase activities in clarias gariepinus (Burchell, 1822)4
Long-term toxicity of fluoroquinolones: a comprehensive review4
Induced oxidative stress and apoptosis by 1-bromopropane in SH-SY5Y cells correlates with inhibition of Nrf2 function4
Artemisia vulgaris L., Artemisia alba Turra and their constituents reduce mitomycin C-induced genomic instability in human peripheral blood lymphocyte4
Exploring health beneficial effects of poisonous mushroom Paxillus involutus Batsch Fr.4
Cardiotoxicity induced by xanthatin via activating apoptosis and ERS pathways in zebrafish4
Preclinical safety profile of RC88-ADC：a novel mesothelin-targeted antibody conjugated with Monomethyl auristatin E4
Betaine attenuates sodium arsenite-induced renal dysfunction in rats4
In vitro screening of genotoxicity and mutagenicity of pyriproxyfen in human lymphocytes and Salmonella typhimurium TA98 and TA100 strains4
Di (2-ethyl hexyl) phthalate and its metabolite-induced metabolic syndrome: a review of molecular mechanisms4
Acute toxicity and biodistribution assessment of quantum dots conjugated to lectins from Schinus terebinthifolia leaves (SteLL) and Punica granatum 4
Dermatoprotective effect of Moringa oleifera leaf extract on sodium valproate-induced skin damage in rats4
Ferroptosis: action and mechanism of chemical/drug-induced liver injury4
New oxomethacrylate and acetamide: synthesis, characterization, and their computational approaches: molecular docking, molecular dynamics, and ADME analyses4
Reproductive and developmental toxicity of α-terpineol in Wistar rats4
Sildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation4
Toxicogenetic profile of the monoterpene alpha-terpineol on normal and tumor eukaryotic cells4
Combined effect of fulvestrant and low dose BPA: comparative implications on EMT, apoptosis, and TGF-β1 signaling in HepG2 cells4
Effects of caffeic acid phenethyl ester use and inhibition of p42/44 MAP kinase signal pathway on caveolin 1 gene expression and antioxidant system in chronic renal failure model of rats4
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate4
Effects of quetiapine administration on sperm quality and testicular histology4
Phytochemical analysis, in silico study and toxicity profile ofCycas pectinataBuch.-Ham seed in mice4
In vitro cytogenotoxic evaluation of aripiprazole on human peripheral lymphocytes and computational molecular docking analysis4
Toxicological evaluation of oral exposure to isoniazid: behavioral, biochemical, and histopathological assessments in rats4
Effects of acetaminophen exposure on behavior and erythrocyte nuclear morphology of juvenile Oreochromis niloticus4
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