OOIR: Observatory of International Research

Papers

(The TQCC of Drug and Chemical Toxicology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Evaluating the therapeutic effect and toxicity of theophylline in infertile men with asthenoteratozoospermia: a double-blind, randomized clinical trial study	29
Toxicological evaluation of ethanolic extract of leaves from Doliocarpus dentatus in Swiss mice	23
In vitro evaluation of the selective cytotoxicity and genotoxicity of three synthetic ortho -nitrobenzyl derivatives in human cancer cell lines, with	22
Unraveling the hepatoprotective and anti-pancreatic cancer potential of Caralluma europaea : a comprehensive in vivo, in vitro and in sili	20
Investigation of the role of K _ATP channels in the cytotoxic effect of cypermethrin on rat-derived aortic smooth muscle cells	17
Antioxidant capacity, acute and sub-acute oral toxicity, and in vivo anti-inflammatory effects of Tetradenia riparia hydroalcoholic extrac	17
The ameliorative effect of rosmarinic acid and epigallocatechin gallate against doxorubicin-induced genotoxicity	17
Gastroprotective mechanism of Talinum triangulare on ethanol-induced gastric ulcer in Wistar rats via inflammatory, antioxidant, and H	17
Genotoxic effects of gadobutrol and gadoversetamide active substances used in magnetic resonance imaging in human peripheral lymphocytesin vitro	16
Tinospora Cordifolia and Arabinogalactan in combination modulates benzo(a)pyrene-induced genotoxicity during lung carcinogenesis	15
Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum)extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model	15
Amelioration of metabolic disorders in H9C2 cardiomyocytes induced by PM _2.5 treated with vitamin C	15
Effect of chlorpyrifos on some biochemical changes in Cyprinus carpio: the protective effect of ellagic acid	15
Population pharmacokinetics and pharmacodynamics of L-asparaginase and its impact on the development of pancreatitis and hypersensitivity reactions in children with leukemia under treatment	14
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea	14
Opioid poisoning cases aged 50+ in the 2015–2020 National Poisoning Data System: suspected suicides versus unintentional poisoning and other intentional misuse/abuse	14
Oxidative stress and inflammatory markers in streptozotocin-induced acute and subacute toxicity response	14
Non-permitted food colorants induced neurotoxicity in cerebellum of rat brain	13
Changes in hormones, Leukocyte Telomere Length (LTL), and p16^INK4a expression in SM-exposed individuals in favor of the cellular senescence	13
Manganese mitigates against hepatorenal oxidative stress, inflammation and caspase-3 activation in rats exposed to hexachlorobenzene	13
MiADMSA abrogates sodium tungstate-induced oxidative stress in rats	12
Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats	12
Assessment of morin hydrate as a renal protective agent in rats subjected to methotrexate-induced nephrotoxicity	12
Silymarin attenuates cobalt chloride-induced redox imbalance and cardio-renal dysfunctions in rats	12
Evaluation of acute and 28-day repeated dose toxicity of Tolypocladium sinense soft capsule in Sprague-Dawley rats	12

Screening and toxicity evaluation of natural compounds as adenosine 2a and 2b receptor ligands: insights from molecular docking, dynamics, and ADMET analysis	11
Pelargonidin ameliorates reserpine-induced neuronal mitochondrial dysfunction and apoptotic cascade: a comparative in vivo study	11
Synergistic hepatoprotective effects of ω-3 and ω-6 fatty acids from Indian flax and sesame seed oils against CCl ₄ -induced oxidative stress-mediated liver damage i	11
Protective effect of neurotensin receptor-1 agonist PD 149163 against lipopolysaccharide-induced gut toxicity in mice	11
Toothpastes for children and their detergent contents affect molecular mechanisms of odontogenesis in zebrafish embryos	10
NO-mediated DNA damage induced by polystyrene nanoparticles triggers program cell death in mesenchymal stem cells	10
Tauroursodeoxycholic acid suppresses biliary epithelial cell apoptosis and endoplasmic reticulum stress by miR-107/NCK1 axis in a FXR-dependent manner	10
Renal tubular response to titanium dioxide nanoparticles exposure	10
Toxicity of pesticide cocktails in amphibian larvae: understanding the impact of agricultural activity on aquatic ecosystems in the Salado River basin, Argentina	10
Linolenic acid stimulates eryptosis and hemolysis through oxidative stress and CK1α/MLKL: protective role of melatonin, urea, and polyethylene glycol	10
Investigation of oxidative, inflammatory and apoptotic effects of favipiravir use alone and combined with vitamin C on brain tissue of elderly rats	10
Content of potentially toxic elements (PTEs) in coffee and coffee-based products: a meta-analysis study, Systematic review, and health risk assessment	10
Probiotics modulation of the endotoxemic effect on the gut and liver of the lipopolysaccharide challenged mice	9
Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats	9
Toxicity study of compound honeysuckle moisturizing Chinese herbal extract by oral gavage for 13 weeks in sprague dawley rats	9
Antioxidant and in vitro cytogenotoxic properties of Amburana cearensis (Allemão) A.C.Sm. leaf extract	9
Naringenin mitigates cadmium-induced cell death, oxidative stress, mitochondrial dysfunction, and inflammation in KGN cells by regulating the expression of sirtuin-1	9
Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations in zebrafish	9
TiO ₂ nanoparticles: green synthesis, characterization, and investigation of antimicrobial properties, and developmental toxicity in zebrafish ( Danio	9
Preventive treatment with sodium para-aminosalicylic acid inhibits manganese-induced apoptosis and inflammation via the MAPK pathway in rat thalamus	9
Modulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells	9
Fumaric acid protects rats from ciprofloxacin-provoked depression through modulating TLR4, Nrf-2, and p190-rho GTP	9
Effect of adenosine triphosphate on methylphenidate-induced oxidative and inflammatory kidney damage in rats	8
Damage to the sarcoplasmic reticulum by venom of the Mexican black-tailed rattlesnake ( Crotalus molossus nigrescens ): inhibition of the Ca ²⁺	8
Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats	8
Single acute and repeated subacute toxicity evaluations of Annona atemoya leaf extract with in vitro anti-inflammatory potential	8
Study on the acute and subchronic oral toxicity of Calculus Bovis Sativus in rats	8
Long term integrated biomarker responses in freshwater African catfish Clarias gariepinus exposed to a new brand of herbicide fluazifop-p-butyl	8
Safety assessment of Wuzhuyu decoction extract: acute and subacute oral toxicity studies in rats	8
Evaluation of toxicological profile of omeprazole degradation impurities in an intravenous drug product: omeprazole-sulfone and omeprazole-N-oxide	8
Cyclosporine-A induced cytotoxicity within HepG2 cells by inhibiting PXR mediated CYP3A4/CYP3A5/MRP2 pathway	8
Pentoxifylline inhibits phosgene-induced lung injury via improving hypoxia	8
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway	8
Prognostic value of systemic immune-inflammation index and monocyte-to-HDL-cholesterol ratio in early cardio-cerebral complications in elderly patients with acute severe carbon monoxide poisoning	8
The protective effect of chrysin against oxidative stress and organ toxicity in rats exposed to propetamphos	7
Toxicological assays in the evaluation of safety assessment of fibrinolytic enzymes	7
Kidney damage following a 90-day subchronic inhalation exposure to HTP aerosol in SD rats	7
Involvement of oxidative stress and toll-like receptor-4 signaling pathways in gentamicin-induced nephrotoxicity in male Sprague Dawley rats	7
Assessment of the effect of sodium tetraborate on oxidative stress, inflammation, and apoptosis in lead-induced nephrotoxicity	7
In vitro antibacterial and anti-inflammatory effects of Anacardium occidentale L. extracts and their toxicity on PBMCs and zebrafish embryos	7
Uncoupling as initiating event in mitochondrial dysfunction after diuron exposure	7
Assessment of the toxicity of different antiretroviral drugs and their combinations on Sertoli and Leydig cells	7
B-Raf inhibitor vemurafenib counteracts sulfur mustard-induced epidermal impairment through MAPK/ERK signaling	7
Chronic bisphenol A exposure induces temporal neurobehavioral transformation and augmented chromatin condensation in the periventricular gray zone of zebrafish brain	7
Pre-clinical and cellular safety assessment of oral administered DHA rich microalgae oil from Schizochytrium sp. (Strain ATCC-20889): acute, sub-chronic and genotoxicity	7
Comparative cytotoxicity induced by parabens and their halogenated byproducts in human and fish cell lines	6
Fluoroquinolone antibiotics in the aquatic environment: environmental distribution, the research status and eco-toxicity	6
Chronic levamisole exposure in male rats alters sexual behavior and induces apoptosis in the testis	6
Salvianolic acid A suppresses CCl₄-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways	6
Both acute glyphosate and the aminomethylphosphonic acid intoxication decreased the acetylcholinesterase activity in rat hippocampus, prefrontal cortex and gastrocnemius muscle	6

Nigella sativa oil reduces oxidative/nitrosative stress in the salivary gland of rats exposed to total cranial irradiation	6
Phycocyanin improved alcohol-induced hepatorenal toxicity and behavior impairment in Wistar rats	6
Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos	6
A study on Wistar Albino rats: investigating protective role of ramelteon on liver damage caused by methotrexate	6
Computational modeling ( in silico ) methods combined with ecotoxicological experiments ( in vivo ) to predict the environmental risks of	6
A comparison of the potential of melatonin and tryptophan to ameliorate CCl ₄ -induced hepatic and renal toxicity in Wistar rats	6
Effect ofMoringa oleiferaleaf extract on valproate-induced oxidative damage in muscle	6
Protective effects ofp-coumaric acid against gentamicin-induced nephrotoxicity in rats	6
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats	5
Genotoxic and genoprotective effects of phytoestrogens: a systematic review	5
Omeprazole induces profibrotic gene expression in rat kidney: implication of TGF-β/Smad signaling pathway	5
MiR-27b-3p ameliorates DOX-induced cardiotoxicity by suppressing myocardial inflammation and oxidative stress in mice and cardiomyocytes	5
In vitro and in vivo genotoxicity assessments of Ficus erecta Thunb. leaves extract support its functional and pharmace	5
Computational design and evaluation of low-toxicity saquinavir analogues targeting the catalytic dyad and oxyanion-hole loop of SARS-CoV-2 Mpro: insights from ensemble docking, molecular dynamics, dyn	5
Eight-year epidemiological study for drug poisoning in Qassim, Saudi Arabia, 2008–2015	5
Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems	5
Evaluation of XQ528 tartrate on embryo-fetus developmental toxicity in SD rats and genotoxicity	5
Single and repeat-dose toxicity and local tolerance assessment of newly developed oil emulsion adjuvant formulations for veterinary purposes	5
Ameliorative effects of nutritional minerals on lead-induced hematological alterations in male Wistar albino rats	5
Electronic cigarette aerosol increases the risk of organ dysfunction by enhancing oxidative stress and inflammation	5
Effects of methiopropamine on cognitive function and monoaminergic systems in mice	5
Phytochemical composition, cytotoxicity, antioxidant and antimicrobial responses of Lavandula dentata L. grown under different levels of heavy metals stress condition	5
Exploring the toxicity profile of coriander ( C. sativum L.) essential oil: implications for translational toxicological research	5
Toxicogenetic profile of the monoterpene alpha-terpineol on normal and tumor eukaryotic cells	5
Acute and 13 weeks subchronic toxicological evaluation of the flavonoid-rich extract of Sophora flavescens	5
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate	4
Acute toxicity and biodistribution assessment of quantum dots conjugated to lectins from Schinus terebinthifolia leaves (SteLL) and Punica granatum	4
Protective effects of a chemically characterized extract fromsolanum torvumleaves on acetaminophen-induced liver injury	4
Artemisia vulgaris L., Artemisia alba Turra and their constituents reduce mitomycin C-induced genomic instability in human peripheral blood lymphocyte	4
New oxomethacrylate and acetamide: synthesis, characterization, and their computational approaches: molecular docking, molecular dynamics, and ADME analyses	4
Induced oxidative stress and apoptosis by 1-bromopropane in SH-SY5Y cells correlates with inhibition of Nrf2 function	4
A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine	4
Preclinical safety profile of RC88-ADC：a novel mesothelin-targeted antibody conjugated with Monomethyl auristatin E	4
Exploring health beneficial effects of poisonous mushroom Paxillus involutus Batsch Fr.	4
Potential protective effects of Acacia nilotica (L.) against gentamicin - induced nephrotoxicity by suppressing renal redox imbalance, inflammatory stress and caspase-de	4
Di (2-ethyl hexyl) phthalate and its metabolite-induced metabolic syndrome: a review of molecular mechanisms	4
Ferroptosis: action and mechanism of chemical/drug-induced liver injury	4
In vitro screening of genotoxicity and mutagenicity of pyriproxyfen in human lymphocytes and Salmonella typhimurium TA98 and TA100 strains	4
Toxicological evaluation of oral exposure to isoniazid: behavioral, biochemical, and histopathological assessments in rats	4
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats	4
Evaluation of antifungal activity, mechanisms of action and toxicological profile of the synthetic amide 2-chloro- N -phenylacetamide	4
Dermatoprotective effect of Moringa oleifera leaf extract on sodium valproate-induced skin damage in rats	4
In vitro cytogenotoxic evaluation of aripiprazole on human peripheral lymphocytes and computational molecular docking analysis	4
Potential neuroprotective effects of 2-hydroxypropyl-β cyclodextrin against amyloid β (1-42)-induced neurotoxicity on the rat hippocampus	4
Protective effects of perindopril against indomethacin-induced gastric mucosal damage through modulation of DDAH-1/ADMA and ACE-2/ANG-(1-7) signaling pathways	4
Hydromorphone impurity 2,2-bishydromorphone does not exert mutagenic and clastogenic properties via in silico QSAR prediction and in vitro Ames and micronucleus test	4
The effect of preconditioning agents on cardiotoxicity and neurotoxicity of carbon monoxide poisoning in animal studies: a systematic review	4
Heavy metal mixture induced hippocampal toxicity involve biometal accumulation, increase in oxidative stress, inflammation, and caspase-3 activation in rats via Nrf-2/HO-1/BDNF pathway	4
Phytochemical analysis, in silico study and toxicity profile ofCycas pectinataBuch.-Ham seed in mice	4
Correction	4
Long-term toxicity of fluoroquinolones: a comprehensive review	4
Betaine attenuates sodium arsenite-induced renal dysfunction in rats	4
Acute exposure to environmentally relevant concentrations of pharmaceutical pollutants induces neurobehavioral toxicity in zebrafish ( Danio rerio )	4
Effects of acetaminophen exposure on behavior and erythrocyte nuclear morphology of juvenile Oreochromis niloticus	4
Sildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation	4
Reproductive and developmental toxicity of α-terpineol in Wistar rats	4
Effects of burnt tire-ash on Na⁺/K⁺, Ca²⁺-ATPase, serum immunoglobulin and brain acetylcholinesterase activities in clarias gariepinus (Burchell, 1822)	4
Cardiotoxicity induced by xanthatin via activating apoptosis and ERS pathways in zebrafish	4
Hepatoprotective effect of methanol fruit extract of Punica granatum L in highly active antiretroviral therapy-induced toxicity in Wistar rats	4
Mandarin peel ethanolic extract attenuates diclofenac sodium induced hepatorenal toxicity in rats by mitigating oxidative stress and inflammation	4