OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Cardiovascular Pharmacology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
The Adenylate Cyclase Activator Forskolin Potentiates the Positive Inotropic Effect of the Phosphodiesterase Inhibitor Milrinone But Not of the Calcium Sensitizer Levosimendan nor of Its Hemodynamical	58
Pleiotropic Effects of Icariside II on the Cardiovascular System: Novel Applications of Ethnopharmacology in Targeting Vascular Remodeling	56
Imatinib as a Tool Against COVID-19: A Balancing Act Between Effectiveness and Cardiac Safety	39
Abatacept Decreases Renal T-cell Infiltration and Renal Inflammation and Ameliorates Progressive Renal Injury in Obese Dahl Salt-sensitive Rats Before Puberty	39
N-N-Butyl Haloperidol Iodide Mitigates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1-Nrf2 Signaling Loop	32
Efficacy and Safety of De-escalation of Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome: A Meta-Analysis of Randomized Clinical Trials	30
Cardiotoxicity of Chemotherapeutic Drugs: An Update and Future Perspectives	29
Inflammation and Heart Diseases: Immunology, Cardiology, and Rheumatology	28
Antiplatelet Therapy Before Transcatheter Aortic Valve Replacement: Unravelling the Optimal Approach	27
Matrix Metalloproteinase 2 Is Crucial for Hypertension- and Hyperglycemia-Induced Kidney Injury Independent of Blood Pressure	26
Clinical Outcomes of Individualized Antiplatelet Therapy Based on Platelet Function Test in Patients After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis	25
Consideration Regarding the Analysis of Randomized Controlled Trials in the Era of Evidence-based Medicine	25
Esaxerenone Blocks Vascular Endothelial Inflammation Through SGK1	23
Intestinal Flora Metabolite Trimethylamine Oxide Is Inextricably Linked to Coronary Heart Disease	22
Electron Transport Chain Inhibition to Decrease Injury in Transplanted Donation After Circulatory Death Rat Hearts	21
N-Acetylcysteine to Reduce Mortality for Patients Requiring Cardiac Catheterization or Cardiac Surgery: A Systematic Review and Meta-analysis	20
Ameliorative Role of Fluconazole Against Abdominal Aortic Constriction–Induced Cardiac Hypertrophy in Rats	20
PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate–Activated Protein Kinase Activation	20
Real-World Outcomes of Proprotein Convertase Subtilisin Kexin-9 Inhibitor Use	19
αv Integrin Affinity/Specificity and Antiangiogenesis Effect of a Novel Tetraaza Cyclic Peptide Derivative, SU015, in Various Species: Retraction	18
Relationship Between Canagliflozin, Sodium Glucose Cotransporter 2 Inhibitor, and Hematopoietic Effects in Patients With Diabetes and Mild Heart Failure: Results From the CANDLE Trial	17
Influence of Regional Nerve Block in Addition to General Anesthesia on Postoperative Delirium, Pain, and In-hospital Stay in Patients Undergoing Cardiothoracic Surgery: A Meta-analysis	17
Efficacy and Safety of Clopidogrel Versus Ticagrelor as Part of Dual Antiplatelet Therapy in Acute Coronary Syndrome—A Systematic Review and Meta-analysis	16
Catalysts of Cardiovascular Electromechanical Harmony? Unveiling the Impact of RAS Inhibitors and ARNI on Atrial Fibrillation Recurrence After Ablation	16
Anti-inflammatory (Colchicine) Treatment for Secondary Prevention in Coronary Artery Disease: A Milestone has Been Met	16

Renal Safety and Renin–Angiotensin–Aldosterone System Inhibitors in Patients With Contrast Media Exposure: A Multicenter Randomized Controlled Study	16
R-spondin 3 Inhibits High Glucose-Induced Endothelial Activation Through Leucine-Rich G Protein-Coupled Receptor 4/Wnt/β-catenin Pathway	16
Proteinopathy: Shared Feature Between the Heart and Brain in Alzheimer's Disease	15
Efficacy and Safety of Cilostazol for Atherosclerosis: A Meta-analysis of Randomized Controlled Trials	14
Lipoprotein(a) and Cardiovascular Disease: A Missing Link for Premature Atherosclerotic Heart Disease and/or Residual Risk	14
Spock2 Functions as a Key Time-Series Gene of Endothelial Cells in Sepsis-Induced Cardiomyopathy	14
What Role do Mitochondria Have in Diastolic Dysfunction? Implications for Diabetic Cardiomyopathy and Heart Failure With Preserved Ejection Function	14
Angiotensin-(1-7) Treatment Early in Life Prevents Cardiac Hypertrophy in Adult Hypertensive Rats	14
Metolazone Versus Chlorothiazide in Acute Heart Failure Patients With Diuretic Resistance and Renal Dysfunction: A Retrospective Cohort Study	14
Subcellular β-Adrenergic Receptor Signaling in Cardiac Physiology and Disease	14
LincRNA RMRP Regulates Phenylephrine-induced Cardiomyocyte Hypertrophy by Means of Targeting miR-1	13
Effect of Dexmedetomidine on Tachyarrhythmias After Cardiac Surgery: A Systematic Review and Meta-Analysis	13
Mesenchymal Stem Cells Alleviate Mouse Sepsis-Induced Cardiomyopathy by Inhibiting the NR1D2/LCN2 Pathway	13
Is Metformin Cardioprotective? A New Piece to the Puzzle	13
Nicotinamide Mononucleotide Alleviates Angiotensin II-Induced Human Aortic Smooth Muscle Cell Senescence in a Microphysiological Model	13
Trough Concentration Deficiency of Rivaroxaban in Patients With Nonvalvular Atrial Fibrillation Leading to Thromboembolism Events	13
Bretschneider Solution and Two Antianginal Drugs Protect Peripheral Tissue in an Animal Model of Hemorrhagic Shock	13
The Impact of Hydrogen Sulfide in the Paraventricular Nucleus on the MAPK Pathway in High Salt–Induced Hypertension	13
The Critical Effect of Bile Acids in Atherosclerosis	12
Cardiovascular Protection Associated With Cilostazol, Colchicine, and Target of Rapamycin Inhibitors	12
Dapagliflozin Suppresses Isoprenaline-Induced Cardiac Hypertrophy Through Inhibition of Mitochondrial Fission	12
Key circRNAs, lncRNAs, and mRNAs of ShenQi Compound in Protecting Vascular Endothelial Cells From High Glucose Identified by Whole Transcriptome Sequencing	12
miR-320a Targeting RGS5 Aggravates Atherosclerosis by Promoting Migration and Proliferation of ox-LDL–Stimulated Vascular Smooth Muscle Cells	12
Evaluation and Management of Pericarditis in Rheumatic Diseases	12
Nischarin Is Not the Functional I1 Imidazoline Receptor Involved in Blood Pressure Regulation	12
Homocysteine Suppresses Autophagy Through AMPK-mTOR-TFEB Signaling in Human THP-1 Macrophages	12
Reevaluating Anticoagulation in Antiphospholipid Syndrome: The Role of Apixaban in the Current Treatment Paradigm	11
Duration of Dual Antiplatelet Therapy in East Asians: Finding the Balance Between Effectiveness and Safety	11
CircLDLR Modulates the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Coronary Artery Disease Through miR-26-5p/KDM6A Axis	11
Selatogrel: A Novel Subcutaneous P2Y12 Inhibitor	11
Proprotein Convertase Subtilisin Kexin-9 Inhibitors (PCSK9i) in Atherosclerotic Cardiovascular Disease: Real-World Data Welcome	11
Influence of Hypersensitive C-Reactive Protein on the Effect of Continuous Antihypertensive Pharmacological Therapy	11
Effects of Recombinant Human Brain Natriuretic Peptide on Atrial Fibrillation After Coronary Artery Bypass Grafting	11
Interleukin-1 Inhibition for the Prevention and Treatment of Heart Failure	11
In Memoriam Tribute to Michael R. Rosen: A Life Well Lived	11
Intravenous to Oral Transition of Amiodarone (IOTA): Effect of Various Durations of Overlap on Atrial Fibrillation Recurrence After Cardiothoracic Surgery	11
Direct Acting Oral Anticoagulants Following Gastrointestinal Tract Surgery	11
Oral Oncolytics and Cardiovascular Risk Management and Monitoring: Erratum.	11
Oral Oncolytics and Cardiovascular Risk Management and Monitoring	10
Intrauterine and Lactational Exposure to Paracetamol: Cardiometabolic Evaluation in Adult Female and Male Offspring	10
Statin and Postcardiac Surgery Atrial Fibrillation Prevention: A Systematic Review and Meta-Analysis	10
Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro	10
Inhibiting NFAT5 With KRN2 Mitigates Acute Allograft Rejection in a Murine Heart Transplantation Model	10
Does Intensity Really Matter to Improve Cardiorespiratory Fitness in Patients With Heart Failure With Preserved Ejection Fraction?	10
Naturally Occurring Atherosclerosis Progression and In-stent Restenosis: Exploring Histomorphologic Associations Using Optical Coherence Tomography	10
Potential Novel RNA-Targeting Agents for Effective Lipoprotein(a) Lowering: A Systematic Assessment of the Evidence From Completed and Ongoing Developmental Clinical Trials	10
Dual Inhibition of Factor XIIa and Factor XIa Produces a Synergistic Anticoagulant Effect	10
Knockdown of Circular Ubiquitin-specific Peptidase 9 X-Linked Alleviates Oxidized Low-density Lipoprotein-induced Injuries of Human Umbilical Vein Endothelial Cells by Mediating the miR-148b-3p/KLF5 S	10
Adrenal G Protein-Coupled Receptors and the Failing Heart: A Long-distance, Yet Intimate Affair	10
Sjogren Syndrome and Outcomes of Acute Myocardial Infarction: A Propensity Score–Matched Analysis of the Nationwide Inpatient Sample 2005–2018	10

Prescription Rates and Prognostic Implications of Optimally Targeted Guideline-Directed Medical Treatment in Heart Failure and Atrial Fibrillation: Insights From The MISOAC-AF Trial	10
Development and Current Role of Sodium Glucose Cotransporter Inhibition in Cardiorenal Metabolic Syndrome	9
Contractile Effects of Amphetamine, Pseudoephedrine, Nor-pseudoephedrine (Cathine), and Cathinone on Atrial Preparations of Mice and Humans	9
Statin Treatment Intensity, Discontinuation, and Long-Term Outcome in Patients With Acute Myocardial Infarction and Impaired Kidney Function	9
Colchicine and Acute Coronary Syndromes: A New Trick for an Old Drug?	9
Central Sleep Apnea in Patients With Coronary Heart Disease Taking P2Y12 Inhibitors	9
Dual Antiplatelet Therapy After Drug-Eluting Stents Implantation in East Asians: A Network Meta-Analysis of Randomized Controlled Trials	9
Sodium Hydrosulfide Reverts Chronic Stress–Induced Cardiovascular Alterations by Reducing Oxidative Stress	9
Nondual Antiplatelet Therapy Versus Dual Antiplatelet Therapy Before Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-analysis	9
Protocatechuic Aldehyde Alleviates d-Galactose–Induced Cardiomyocyte Senescence by Regulating the TCF3/ATG5 Axis	9
Tumor Necrosis Factor-α Mediates Inflammation-induced Early-Stage Left Ventricular Systolic Dysfunction	9
Management of Iron Deficiency in Heart Failure: A Review of Evidence	9
The Combination of Valsartan and Spironolactone Mitigated Mitral Regurgitation–Induced Cardiac Dysfunction in a Novel Rat Model	9
Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload–Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes	8
Autoantibodies and Cardiomyopathy: Focus on Beta-1 Adrenergic Receptor Autoantibodies	8
The Impaired Mechanism and Facilitated Therapies of Efferocytosis in Atherosclerosis	8
Long Noncoding RNAs Testis Development Related Gene 1 Aggravates Transforming Growth Factor-β1–Induced Fibrogenesis and Inflammatory Response of Cardiac Fibroblasts Via miR-605-3p/Tumor Necrosis Facto	8
Muscarinic Receptor Activation Reduces Force and Arrhythmias in Human Atria Independent of IK,ACh	8
Current Perspectives of the Use of Sodium–Glucose Transport-2 Inhibitors for Patients With Heart Failure and Chronic Kidney Disease	8
Trimetazidine Affects Mitochondrial Calcium Uniporter Expression to Restore Ischemic Heart Function via Reactive Oxygen Species/NFκB Pathway Inhibition	8
Nanobodies as Probes and Modulators of Cardiovascular G Protein–Coupled Receptors	8
Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling	8
Cardioprotective and Antianginal Efficacy of Nicorandil: A Comprehensive Review	8
Nrf2 Ameliorates Atrial Fibrosis During Antithrombotic Therapy for Atrial Fibrillation by Modulating CYP2C9 Activity	8
Hesperetin Inhibits Sphingosylphosphorylcholine-Induced Vascular Smooth Muscle Contraction by Regulating the Fyn/Rho-Kinase Pathway	8
Role of Collagen in Vascular Calcification	8
Effectiveness and Safety of P2Y12 Inhibitor Pretreatment for Primary PCI in STEMI: Systematic Review and Meta-analysis	8
E3 Ubiquitin Ligases in Endothelial Dysfunction and Vascular Diseases: Roles and Potential Therapies	8
Cannabinoids and Postcardiac Surgery: Preclinical Insights Pave the Way for Future Research	8
Improvement of Global Longitudinal Strain and Myocardial Work in Type 2 Diabetes Patients on Sodium–Glucose Cotransporter 2 Inhibitors Therapy	8
CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells	8
Treatment of Immune Checkpoint Inhibitor-associated Myocarditis	8
Disrupting circ-GNB4 mitigates high glucose-induced human mesangial cells injury by regulating the proliferation, ECM accumulation, inflammation and oxidative stress through circ-GNB4/miR-23c/EGR1 pat	7
Efficacy and Safety of Shortened Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Controlled Trials	7
Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats	7
Golgi Protein 73 Promotes LPS-Induced Cardiac Dysfunction via Mediating Myocardial Apoptosis and Autophagy	7
Impact of Trimetazidine on the Incident Heart Failure After Coronary Artery Revascularization	7
Comparative Effectiveness and Safety of Milrinone and Levosimendan as Initial Inotrope Therapy in Patients With Acute Heart Failure With Renal Dysfunction	7
Glucocorticoids Promote Na+ Excretion in the Renal Epithelia of Heart Failure Rats by Suppressing Transporter Proteins Involved in Acute Sodium Loading	7
Glutathione S-Transferase α4 Alleviates Hyperlipidemia-Induced Vascular Neointimal Hyperplasia in Arteriovenous Grafts via Inhibiting Endoplasmic Reticulum Stress	7
The Efficacy of Traditional Chinese Herbal Medicine Across Multiple Cardiovascular Diseases: An Umbrella Review of Systematic Reviews of Randomized Controlled Trials	7
Vasodilatation: One Question with Many Answers	7
Vasodilator Dysfunction in Human Obesity: Established and Emerging Mechanisms	7
Feedback Interaction Between Apelin and Endoplasmic Reticulum Stress in the Rat Myocardium	7
Clinical Outcomes After Percutaneous Coronary Intervention Over Time on the Basis of CYP2C19 Polymorphisms	7
Antithrombotic Treatment Regimens in Patients Undergoing Percutaneous Coronary Revascularization Requiring Oral Anticoagulation: What Real-World Evidence Shows Us	7
The Long-Standing Search for Albumin Placement in Acute Heart Failure	7
Alpha-lipoic Acid Protects Against Chronic Alcohol Consumption-induced Cardiac Damage by the Aldehyde Dehydrogenase 2–associated PINK/Parkin Pathway	7
Gab1 Overexpression Alleviates Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis Through PI3K/Akt Signaling Pathway	7
Metformin Prevents Low-dose Isoproterenol-induced Cardiac Dilatation and Systolic Dysfunction in Male Sprague Dawley Rats	7
Colchicine for Patients With Coronary Artery Disease: A Systematic Review and Meta-analysis	7
Apelin-Induced Relaxation of Coronary Arteries Is Impaired in a Model of Second-Hand Cigarette Smoke Exposure	7
The Role of SGLT2 Inhibitors on Heart Failure Outcomes in Nondiabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Erratum	7