Journal of Affective Disorders

Article	Citations
Non-superiority of zuranolone (SAGE-217) at the longer-term	766
Editorial Board	368
Prospective association of comorbid hypertension and depressive symptoms with C-reactive protein in older adults	338
Discrimination and perinatal depressive symptoms: The protective role of social support and resilience	288
Large-scale network abnormality in behavioral addiction	245
Prevalence and impact of depression and anxiety among older myocardial infarction survivors: A nationwide cohort study	189
Dynamic associations between frailty and cognition over 4 years: A population-based study on adults aged ≥50 from 12 European countries	181
Causal effects of childhood obesity on neuroticism and subjective well-being: A two-sample Mendelian randomization study	171
Causal association between years of schooling and the risk of traumatic brain injury: A two-sample mendelian randomization analysis	162
Novelty–retrieval–extinction paradigm to decrease high-intensity fear memory recurrence	144
The associations of social health, self-injurious thoughts and behaviors with or without childhood trauma: A UK biobank study	135
Corrigendum to “Trajectories of Chinese adolescent depression before and after COVID-19: A cross-temporal meta-analysis with segmented regression” [J. Affect. Disord. 373 (2025) 333–344]	129
Mental health trajectories among the general population and higher-risk groups following the COVID-19 pandemic in Switzerland, 2021–2023	127
The associations between dietary flavonoids intake and risk of depressive symptom in diabetic patients: Data from NHANES 2007–2008, 2009–2010, and 2017–2018	127
Associations of meeting 24-hour movement behavior guidelines with social and emotional function in youth with ASD/ADHD	126
Risk prediction models of depression in older adults with chronic diseases	123
Smoking status: A tacit screen for postpartum depression in primary care settings	119
Trajectories of Chinese adolescent depression before and after COVID-19: A cross-temporal meta-analysis with segmented regression	118
Multifractal dynamic changes of spontaneous brain activity in psychiatric disorders: Adult attention deficit-hyperactivity disorder, bipolar disorder, and schizophrenia	112
Prevalence and impact of parental co-morbid anxiety and depression during the first 2 years postpartum in China	110
Targeting the gut microbiota-inflammation-brain axis as a potential therapeutic strategy for psychiatric disorders: A Mendelian randomization analysis	108
Day-to-day variability in sleep and activity predict the onset of a hypomanic episode in patients with bipolar disorder	104
Biased attention allocation in major depressive disorder: A replication and exploration of the potential effects of depression history	103
How does family functioning contribute to child externalizing and internalizing behavior problems after childhood TBI? Evidence from a prospective cohort study	97
Potential associations between altered brain function, cognitive deficits and gene expressing profiles in bipolar disorder across three clinical stages	96

Compromised B-cell homeostasis: Unraveling the link between major depression, infection and autoimmune disorders	95
Atypical subcortical involvement in emotional face processing in major depressive disorder with and without comorbid social anxiety	93
Risk factors associated with postpartum anxiety in Australia, Europe, and North America: A systematic review and narrative synthesis	92
Association of different emotional support status with cardio-cerebrovascular diseases	91
The impact of cortical and subcortical volumes on major depression risk: A genetic study	90
Effects of electroconvulsive therapy on functional connectome abnormalities in adolescents with depression and suicidal ideation	90
Meta-analysis of prospective longitudinal cohort studies on the impact of childhood traumas on anxiety disorders	89
Explaining the pathways through which social capital buffered mental health during the COVID-19 pandemic: A longitudinal analysis	88
Benzodiazepines consumption may have increased during the COVID-19 pandemic	85
Prevalence of depressive symptoms in people aged 50 years and older: A retrospective cross-sectional study	85
Discriminative analysis of schizophrenia and major depressive disorder using fNIRS	84
School bullying associated suicidal risk in children and adolescents from Yunnan, China: The mediation of social support	84
The role of equanimity in mediating the relationship between psychological distress and social isolation during COVID-19	84
Poor mental health is associated with loneliness and boredom during Covid-19-related restriction periods in patients with pre-existing depression	84
Prenatal determinants of anxiety symptoms in middle childhood. Evidence from Growing Up in New Zealand	83
The relationship between wearable-derived sleep features and relapse in Major Depressive Disorder	82
Apathy in Alzheimer's disease: Eye movements characteristics and neurostructural basis	81
Post-traumatic stress disorder (PTSD) symptom clusters associated with an indicator of heart rate variability: The ADVANCE cohort study	80
Large-scale digital phenotyping: Identifying depression and anxiety indicators in a general UK population with over 10,000 participants	79
The curvilinear relationship between hepatic steatosis index and depression: Findings from the NHANES	79
Association between adverse perinatal events and postpartum depressive symptoms in a North American prospective preconception cohort study	79
Acute angiotensin receptor blockade and mnemonic discrimination in healthy participants	79
Simple dysmood disorder, a mild subtype of major depression, is not an inflammatory condition: Depletion of the compensatory immunoregulatory system	78
Under the surface: Low cardiac vagal tone and poor interoception in young adults with subclinical depressive symptoms	77
SSRI use is not associated with the intensity of romantic love, obsessive thinking about a loved one, commitment, or sexual frequency in a sample of young adults experiencing romantic love	76
Cognitive hierarchy in mood disorders and relations to daily functioning	76
Cognitive protection and brain entropy changes from omega-3 polyunsaturated fatty acids supplement in late-life depression: A 52-week randomized controlled trial	75
Rumination as a transdiagnostic process: The role of rumination in relation to antisocial and borderline symptoms	75
The relationship between overweight and thyroid function in first-episode, untreated Chinese patients with major depressive disorder with different ages of onset	74
Comorbidity among symptoms of internet gaming disorder, social withdrawal, and depression in 3430 young people in Hong Kong: A network analysis	73
A longitudinal study of lifestyle behaviours in emerging adulthood and risk for symptoms of depression, anxiety, and stress	73
Prevalence of depressive symptoms and its related factors among China's older adults in 2016	73
Network connectivity between anxiety, depressive symptoms and psychological capital in Chinese university students during the COVID-19 campus closure	72
The interaction effect of depressive symptoms and inflammation on the occurrence of cardiovascular diseases	72
The relationship between social anxiety and academic engagement among Chinese college students: A serial mediation model	72
Systematic review and meta-analysis of randomised controlled trials for evaluating the effectiveness of virtual reality therapy for social anxiety disorder	71
Digital phenotyping of depression during pregnancy using self-report data	70
Impulse control behaviors and apathy commonly co-occur in de novo Parkinson's disease and predict the incidence of levodopa-induced dyskinesia	70
The role of alexithymia and perceived stress in mental health responses to COVID-19: A conditional process model	68
The trajectories and associations of eveningness and insomnia with daytime sleepiness, depression and suicidal ideation in adolescents: A 3-year longitudinal study	68
Parental role and peer support in adolescent suicidal behavior in eight South-East Asian countries	67
Vegetarian diet and depression scores: A meta-analysis	67
Looking back on life: An updated meta-analysis of the effect of life review therapy and reminiscence on late-life depression	66
Decreased salience network fMRI functional connectivity following a course of rTMS for treatment-resistant depression	66
Psychometric evaluation of the 9-item Concise Health Risk Tracking - Self-Report (CHRT-SR9) (a measure of suicidal risk) in adolescent psychiatric outpatients in the Texas Youth Depression and Suicide	65
Adverse childhood experiences and depressive symptoms among middle-aged or older adults in China and the mediating role of short sleep duration	65
Improving depression prediction using a novel feature selection algorithm coupled with context-aware analysis	65
Motor alterations in depression and anxiety disorders: A systematic review and meta-analysis	64
Personality traits and depressive symptoms among Chinese older people: A network approach	64
Longitudinal reciprocal associations between depression, anxiety, and substance use disorders over three decades of life	63

Adverse childhood experiences and sleep duration among U.S. 65 years and older: results from the 2020 BRFSS	63
Prevalence and determinants of probable depression and anxiety during the COVID-19 pandemic in seven countries: Longitudinal evidence from the European COvid Survey (ECOS)	62
Altered gut bacterial–fungal interkingdom networks in children and adolescents with depression	62
Association between social withdrawal and suicidal ideation in patients with major depressive disorder: The mediational role of emotional symptoms	62
Vortioxetine 5, 10, and 20 mg significantly reduces the risk of relapse compared with placebo in patients with remitted major depressive disorder: The RESET study	60
CUMS induces depressive-like behaviors and cognition impairment by activating the ERS-NLRP3 signaling pathway in mice	60
Psilocybin-assisted therapy improves psycho-social-spiritual well-being in cancer patients	60
Suicidal ideation among non-physician hospital system staff: Prevalence and workplace correlates	60
Increased low-frequency brain responses to music after psilocybin therapy for depression	59
Familial resemblance in mental health symptoms, social and cognitive vulnerability, and personality: A study of patients with depressive and anxiety disorders and their siblings	59
Prevalence of prolonged grief disorder	59
Evaluating the effect of exercise-based interventions on functioning in people with transdiagnostic depressive symptoms: A systematic review of randomised controlled trials	59
Psychiatric Safety and Weight Loss Efficacy of Naltrexone/bupropion as Add-on to Antidepressant Therapy in Patients with Obesity or Overweight	58
BI-REAL: A 12-session DBT skills group intervention adapted for bipolar disorder – A feasibility randomised pilot trial	58
The impact of the Covid-19 pandemic on postnatal anxiety and posttraumatic stress: Analysis of two population-based national maternity surveys in England	58
Effect of psychotherapy for adult depression on self-esteem: A systematic review and meta-analysis	58
Metabolic factors modulate effort-based decision-making in major depressive disorder	58
The association between trichotillomania symptoms and emotion regulation difficulties: A systematic review and meta-analysis	58
Risk of disruptive behavioural disorders in offspring of mothers with perinatal depressive disorders: A data linkage cohort study	57
Editorial Board	57
Sense of coherence, subjective burden, and anxiety and depression symptoms in caregivers of people with dementia: Causal dynamics unveiled by a longitudinal cohort study in Europe	57
Enhanced network synchronization connectivity following transcranial direct current stimulation (tDCS) in bipolar depression: Effects on EEG oscillations and deep learning-based predictors of clinical	56
Exploring the efficacy and potential of large language models for depression: A systematic review	56
Authors’ response: Mushroom intake and depression: A population-based study using data from the US National Health and Nutrition Examination Survey (NHANES), 2005–2016	55
Reduced attentional control in individuals with a history of suicide attempts compared to those with suicidal ideation: Results from a systematic review and meta-analysis	54
Digital literacy—A new perspective on studying digital interventions for mental health issues	54
Transition to healthier lifestyle associated with reduced risk of incident dementia and decreased hippocampal atrophy	54
Variability in emotion regulation strategy use in major depressive disorder: Flexibility or volatility?	54
The psychological mechanism underlying neuroticism on divorce proneness: The chain mediating roles of negative partner support and couple burnout and the moderating role of economic level	53
Bidirectional relations between depression symptoms and chronic kidney disease	53
Assessment of genetic variants in D2 dopamine receptor (DRD2) gene as risk factors for post-traumatic stress disorder (PTSD) and major depressive disorder (MDD): A systematic review and meta-analysis	53
Therapist-supported digital mental health intervention for depressive symptoms: A randomized clinical trial	53
Clinical presentation of psychotic experiences in patients with common mental disorders attending the UK primary care improving access to psychological therapies (IAPT) Programme	53
Examining tradeoffs between cognitive effort and relief among adults with self-injurious behavior	52
Transcranial focused ultrasound modulates the emergence of learned helplessness via midline theta modification	52
The relationship between adverse childhood experiences and common mental disorders among pregnant women living with HIV in Malawi	52
Intelligent classification of major depressive disorder using rs-fMRI of the posterior cingulate cortex	52
Neuropsychiatric symptoms in Alzheimer's continuum and their association with plasma biomarkers	52
Sex differences in effectiveness and adverse effects of mood stabilizers and antipsychotics: A systematic review	51
The interplay between emotion regulation, interpersonal problems and eating symptoms in individuals with obesity: A network analysis study	51
Efficacy of intravenous ketamine and intranasal esketamine with dose escalation for Major depression: A systematic review and meta-analysis	51
Association between social isolation and depression: Evidence from longitudinal and Mendelian randomization analyses	51
Attentional control deficits and suicidal ideation variability: An ecological momentary assessment study in major depression	51
Dysfunction of neurotransmitter metabolism is associated with the severity of depression in first-diagnosed, drug-naïve depressed patients	51
Olfactory-related quality of life impacts psychological distress in people with COVID-19: The affective implications of olfactory dysfunctions	51
Effect of modified electroconvulsive therapy on neuro metabolites and magnetic resonance spectroscopy imaging signals in patients with refractory obsessive-compulsive disorder	51
Arketamine as adjunctive therapy for treatment-resistant depression: A placebo-controlled pilot study	50
COVID-19-related direct and vicarious racial discrimination: Associations with psychological distress among U.S. college students	50
A multicenter, randomized, double-blind, duloxetine-controlled, non-inferiority trial of desvenlafaxine succinate extended-release in patients with major depressive disorder	50
A scoping review of counseling interventions for suicide prevention in Africa: Few studies address this life-saving aspect of mental health treatment	49
The rapid antidepressant effectiveness of repeated dose of intravenous ketamine and intranasal esketamine: A post-hoc analysis of pooled real-world data	49
Decreased intrinsic neural timescales in obsessive compulsive disorder and two distinct subtypes revealed by heterogeneity through discriminative analysis	48
Comparisons of the amplitude of low-frequency fluctuation and functional connectivity in major depressive disorder and social anxiety disorder: A resting-state fMRI study	48
The moderating role of psychological resilience in the relationship between falls, anxiety and depressive symptoms	48
Risk of depression and anxiety disorders according to long-term glycemic variability	48
Associations of adolescent substance use and depressive symptoms with adult major depressive disorder in the United States: NSDUH 2016–2019	48
Aging anxiety, loneliness, and depressive symptoms among middle-aged adults: The moderating role of ageism	47
Predicting levels of prolonged grief disorder symptoms during the COVID-19 pandemic: An integrated approach of classical data exploration, predictive machine learning, and explainable AI	47
Associations between rest–activity/light-exposure rhythm characteristics and depression in United States adults: A population-based study	47
Family function and emotional behavior problems in Chinese children and adolescents: A moderated mediation model	47
Early mother-infant interactions within the context of childbirth-related posttraumatic stress symptoms	47
Association between living alone and generalized anxiety disorder in Korean adults	47
Global prevalence of depression in menopausal women: A systematic review and meta-analysis	47
Predictors of employment status and stability in Bipolar Disorder: Findings from an 8-year longitudinal study	47
Assessing relinquishment of positivity as a central symptom bridging anxiety and depression	47
Associations between discrimination and adverse mental health symptoms and disorder diagnoses among college students in the United States	46
The needle in the haystack: Identifying and validating common genes of depression, insomnia, and inflammation	46
Associations between insomnia symptoms and inflammatory cytokines in adolescents with first-episode and recurrent major depressive disorder	46
Telomeres are shorter and associated with number of suicide attempts in affective disorders	46
Thalamic abnormalities in older adults with remitted early-onset depression using structural magnetic resonance imaging	46
The role of base excision repair in major depressive disorder and bipolar disorder	45
Symptoms of depression and anxiety in young people in El Salvador: Associations with peer and family relationships, artistic activities and health behaviours during the COVID-19 pandemic	45
Development and validation of nomograms to predict preoperative anxiety and postoperative pain in patients undergoing gynecological surgery: An observational analysis	45
Factor structure, reliability, and validity of the revised Suicide Crisis Inventory in major depression: A multicentric Indian study	45
Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank	45
Clusters of substance use and mental health variables with emergency room visits in U.S. adults: The 2020 National Survey on Drug Use and Health	44
Intrinsic disruption of white matter microarchitecture in major depressive disorder: A voxel-based meta analysis of diffusion tensor imaging	44
COVID-19 and people who use drugs: Impact of the pandemic on general anxiety and depressive disorders among adults in Belgium	44
Normative modeling analysis reveals corpus callosum volume changes in early and mid-to-late first episode major depression	44
Sleep duration and depressive symptoms in Chinese middle-aged and older adults: The moderating effects of grip strength	44

Examining the description of the concept “treatment as usual” for patients with depression, anxiety and stress-related mental disorders in primary health care research – A systematic review	44
Associations between emotional and non-emotional cognition and subsequent mood episodes in recently diagnosed patients with bipolar disorder: A 16-month follow-up study	43
Stressful events as correlates of depressive and PTSD symptoms in Hong Kong women during social unrest and COVID-19 pandemic	43
The role of m6A methylation in prenatal maternal psychological distress and birth outcome	43
Comparative effectiveness of two different doses of botulinum toxin A for the treatment of mild to moderate depression	43
Impacts of combined childhood exposures to poor neighborhood quality, peer friendships and family relationships on adult depression: A seven-year longitudinal study	43
Editorial Board	43
Psychological distress and the risk of drug overdose death	43
Letter to the Editor: Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis	43
Physical inability rather than depression and cognitive impairment had negative effect on centenarian prognosis: A prospective study with 5-year follow-up	43
Effectiveness of digital interventions for people with comorbid heavy drinking and depression: A systematic review and narrative synthesis	43
Association between cardio-metabolic risks and depressive symptoms among US adults (NHANES 2013–2018)	43
Change in cardiovascular health among adults with current or past major depressive disorder enrolled in intensive smoking cessation treatment	43
Chronic pain predicts a worse response to depression treatment, regardless of thyroid function or psychotropics prescribed	42
The protective role of parental involvement at home in negative psychological outcomes among Chinese adolescents during the COVID-19 epidemic	42
“Apples and pears are similar, but still different things.” Bipolar disorder and schizophrenia- discrete disorders or just dimensions ?	42
Sexual orientations in association between childhood maltreatment and depression among undergraduates in mainland of China	42
Editorial Board	42
The effect of bullying victimization on sleep quality among Chinese medical students: Timing, duration, and patterns	42
The Ketamine Side Effect Tool (KSET): A comprehensive measurement-based safety tool for ketamine treatment in psychiatry	42
Suicide risk among combatants: The longitudinal contributions of pre-enlistment characteristics, pre-deployment personality factors and moral injury	42
Mood and neurotic disorders among youth with prenatal substance exposure: A longitudinal register-based cohort study	42
Letter to the editor—Association between depression and risk of Parkinson's disease in South Korean adults	41
Negative parenting style and depression in adolescents: A moderated mediation of self-esteem and perceived social support	41
How the mental health of working parents in Australia changed during COVID-19: A pre- to during pandemic longitudinal comparison	41
The Association Between Employment Status and Mental Health in Young Adults: A Nationwide Population-Based Study in Korea	41
Suicidal risks in rural versus urban populations in Sardinia	41
Detection of bipolar disorder in the prodromal phase: A systematic review of assessment instruments	41
Psychological distress, multimorbidity and health services among older adults in rural South Australia	41
Haplotype phasing of a bipolar disorder pedigree revealed rare multiple mutations of SPOCD1 gene in the 1p36–35 susceptibility locus	41
Comparison of the effect of citalopram, bupropion, sertraline, and tricyclic antidepressants on QTc: A cross-sectional study	41
Triple network connectivity changes in patients with major depressive disorder versus healthy controls via structural network imaging after electroconvulsive therapy treatment	40
The association between leftover food consumption and depression among older adults: Findings from a cross-sectional study	40
Factors related to perceived stress during the COVID-19 epidemic context among the general population in China: A cross-sectional nationwide study	40
Mindfulness-enhanced internet-based cognitive behavioural therapy for anxiety and depression: Outcomes in routine care	40
Commentary on “Maternal psychological stress during pregnancy and risk of congenital heart disease in offspring: A systematic review and meta-analysis”	40
Folic acid does not have an anti-manic effect but protect the brain against oxidative stress in an animal model of mania induced by ouabain	39
Relationship between parental attachment styles and suicide in adolescents and adults admitted to an inpatient psychiatric hospital	39
The temporal dynamics of mood and their association with depressive symptoms in Huntington's disease	39
Does moderate to vigorous physical activity mediate the association between depression and physical function in midlife: Evidence from two British birth cohort studies	39
Early improvement as a predictor of final remission in patients with treatment-resistant depression receiving electroconvulsive therapy with ketofol anesthesia	39
Depression in pregnancy “strongly predicts” depression postpartum: Are we inadvertently misleading clinicians and researchers?	39
Based on white matter microstructure to early identify bipolar disorder from patients with depressive episode	39
A multi-group confirmatory factor analysis of the revised children's anxiety and depression scale (RCADS) in Spain, Chile and Sweden	39
Editorial Board	38
Increased depressive and anxiety symptoms in non-heterosexual individuals: Moderation by childhood factors using a twin design	38
Transitions: Hagop Souren Akiskal	38
Disentangling the impact of childhood abuse and neglect on depressive affect in adulthood: A machine learning approach in a general population sample	38
Socio-economic status and functioning in patients newly diagnosed with bipolar disorder and their unaffected siblings - Results from a cross-sectional clinical study	38
Community mental health services: Access for acute psychiatric care during the COVID-19 lockdown	38
Association between employment stability and depression as moderated by gender among South Korean employees	38
Vengeance is whose? Applying the interpersonal theory of suicide to the titular character in Lev Tolstoy's Anna Karenina	38
Editorial Board	38
The association between stressful experiences and OCD symptoms in young adults at transdiagnostic risk	38
Examining accurate diagnosis of complex PTSD in ICD-11	38
Editorial Board	38
Moral obligation to follow anti-COVID-19 measures strengthens the mental health cost of pandemic burnout	38
Editorial Board	38
Editorial Board	38
The real-world health resource use and costs of misdiagnosing bipolar I disorder	37
Engagement in leisure activities and cognitive function by socioeconomic groups in China: A prospective cohort study	37
Bi-directional associations between depressive symptoms and asthma in middle-aged and elderly adults in China	37
Editorial Board	37
Response to Słupski & Słupska	37
The impact of the 2015 ACOG screening guidelines on the diagnosis of postpartum depression among privately insured women	37
Longitudinal association of family conflict and suicidal behaviors among Chinese adolescents: The mediation effect of internalizing and externalizing problems	37
Commentary on ‘The association between gut-health promoting diet and depression: A mediation analysis’	37
Comment on ‘A comparative analysis of antidepressant and anti-suicidal effects of repeated ketamine infusions in elderly and younger adults with depression’	37
Correspondence: The effects of maternal prenatal depression on child mental health: The moderating role of maternal childhood trauma	37
Associations between heart rate variability, peripheral inflammatory markers and major depressive disorder	36
Editorial Board	36
Factors associated with Korean adolescent's e-cigarette use by the severity level of generalized anxiety disorder (GAD-7)	36
Editorial Board	36
A comparison of cost-effectiveness between offering antidepressant–CBT combinations first or second, for moderate to severe depression in Japan	36
Placebo nasal spray protects female participants from experimentally induced sadness and concomitant changes in autonomic arousal	36
Diagnostic and functional outcomes of adjustment disorder in U.S. active duty service members	36
Editorial Board	36
Major flaws in a meta-analysis of short-term psychodynamic therapy (STPP) for depression	36
Trait anger representation in microstructural white matter tracts: A diffusion MRI study	36
The long psychological shadow of COVID-19 upon healthcare workers: A global concern for action	36
The association between maternal lifetime interpersonal trauma experience and perceived mother-infant bonding	36
Increased levels of anger associated with the French Government's restrictive measures against the COVID outbreak in subjects without pre-existing mental condition vs. patients with history of depress	36
Mental health during the omicron pandemic: A comparison between medical staff and non-medical staff	36
Men who have sex with men were more depressed than their counterparts because of lower social support and higher loneliness: A comparative survey among Chinese university students	36
Associations of resilience and respiratory sinus arrhythmia with alienation among college students	36
Co-occurring PTSD in intensive OCD treatment: Impact on treatment trajectory vs. response	36
Binge drinking and suicidal ideation in Peruvian adolescents: Evidence from a pooled cross-sectional survey	36
Integrated genome-wide methylation and expression analyses provide predictors of diagnosis and early response to antidepressant in panic disorder	36
Associations of dietary Provitamin A carotenoid intake with depressive symptoms in midlife women: Results from the study of Women's Health Across the Nation	35
Severe major depressive disorder readmissions: A national United States population study	35
Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium	35
Commentary on ‘Information flow and dynamic functional connectivity during electroconvulsive therapy in patients with depression’	35
All studies are not created equal: A systematic narrative review of bipolar depression clinical trial inclusion/exclusion rules and baseline severity scores	35
Editorial Board	35
Brain volumetric correlates of electroconvulsive therapy versus transcranial magnetic stimulation for treatment-resistant depression	35