Trends in Pharmacological Sciences

Article	Citations
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Shearing of surface mucin saps tumor cell strength	581
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Advisory Board and Contents	234
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Muscarinic receptors: from clinic to bench to clinic	178
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DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1	163
Swinging the SWI/SNF complexes for cancer therapy	158
Advancing chemical carcinogenicity prediction modeling: opportunities and challenges	149
Monitoring neurodegeneration through brain-derived extracellular vesicles in biofluids	149
Ensifentrine (Ohtuvayre™) for chronic obstructive pulmonary disease	144
Compstatins: the dawn of clinical C3-targeted complement inhibition	140
Structural asymmetry in FGF23 signaling	129
Peptides as a therapeutic strategy against Klebsiella pneumoniae	127
Direct in vivo CAR T cell engineering	123
Targeting complement in neurodegeneration: challenges, risks, and strategies	121
Structural pharmacology and mechanisms of GLP-1R signaling	113
Nemolizumab (Nemluvio®) for prurigo nodularis	97
Therapeutic inhibition of ferroptosis in neurodegenerative disease	97
A smart hospital-driven approach to precision pharmacovigilance	89
Chemically modified neoantigen-based immunotherapy for targeting KRASG12C-driven tumors	89
Leveraging human microbiomes for disease prediction and treatment	87
Advisory Board and Contents	87

Genetically engineered loaded extracellular vesicles for drug delivery	87
Ribosome-directed cancer therapies: the tip of the iceberg?	84
Phenotypic approaches for CNS drugs	84
Optogenetic engineering for precision cancer immunotherapy	81
Mechanistic considerations for adenosine-lidocaine-magnesium (ALM) in controlling coagulopathy	80
Advisory Board and Contents	80
Advisory Board and Contents	79
The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics	76
A deep dive into degrader-induced protein-protein interfaces	75
Emerging strategies for beta cell transplantation to treat diabetes	74
Engineering ACE2 decoy receptors to combat viral escapability	73
A perspective on psychedelic teratogenicity: the utility of zebrafish models	72
siRNA drug Leqvio (inclisiran) to lower cholesterol	70
HSV-1 as a gene delivery platform for cancer gene therapy	66
Close to a year in TIPS’ saddle – I am optimistic	65
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Emerging approaches to induce immune tolerance to therapeutic proteins	64
Bimetallic nanoadjuvants for cancer vaccines	64
GPR35, ally of the anti-ischemic ATPIF1-ATP synthase interaction	61
Deubiquitinating enzymes as therapeutic targets in diabetic nephropathy	60
Thriving as members of under-represented groups in pharmacology-related careers	60
Advisory Board and Contents	59
Subscription and Copyright Information	58
Suzetrigine for moderate to severe acute pain	57
Mentoring future science leaders to thrive	53
Autologous, allogeneic, in vivo CAR for autoimmune diseases	53
Alzheimer’s therapeutic development: shifting neurodegeneration to neuroregeneration	52
Molecular glues evolve from serendipity to rational design	50
Advancing non-destructive analysis of 3D printed medicines	49
Now you serine, now you don't	49
Targeting AMPK as a potential treatment for hepatic fibrosis in MASLD	47
Selective tyrosine kinase 2 inhibitors in inflammatory bowel disease	47
Lipoxygenases in chronic liver diseases: current insights and future perspectives	46
Piezo1: structural pharmacology and mechanotransduction mechanisms	45
The structure, function, and pharmacology of MRGPRs	44
Could dexmedetomidine be repurposed as a glymphatic enhancer?	44
Advisory Board and Contents	43
Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease	41
The promise of targeted protein degradation approaches	41
Salt-inducible kinases: new players in pulmonary arterial hypertension?	41
The road less traveled: activating an oncogenic kinase	41
Targeting LKB1/STK11-mutant cancer: distinct metabolism, microenvironment, and therapeutic resistance	41
Inhalable neutralizing antibodies – promising approach to combating respiratory viral infections	40
Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients	40
A novel function of the M2 muscarinic receptor	38
Promising neuroimmune targets and drugs for CNS diseases	38
The end of the beginning in understanding SLC22 polyspecificity	37
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Beyond G protein and arrestin: GRK2-biased β₂AR signaling	36
Validation of agent-based models of surface receptor oligomerisation	36

Tackling microbial iron homeostasis: novel antimicrobial strategies	36
Advisory Board and Contents	36
Monkeypox: potential vaccine development strategies	35
Protein acylations in cancer immunity: effects and therapeutic opportunities	34
Frizzleds act as dynamic pharmacological entities	34
Artificial intelligence in rare diseases: toward clinical impact	34
PDE4 modulates muscle signaling in cancer cachexia	34
Decoding pseudouridine: an emerging target for therapeutic development	33
BTK inhibitors: past, present, and future	33
Targeting intracellular protein–protein interactions with macrocyclic peptides	33
Advisory Board and Contents	32
Metabolic regulation in normal and leukemic stem cells	32
SEAKER cells coordinate cellular immunotherapy with localized chemotherapy	31
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Recent advances in generative biology for biotherapeutic discovery	30
Demographic diversity in platelet function and response to antiplatelet therapy	30
Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches	30
GPR35: from enigma to therapeutic target	30
Voltage-gated ion channels in epilepsies: circuit dysfunctions and treatments	29
Development of PROTACs using computational approaches	28
Circulating tumor cells in precision medicine: challenges and opportunities	28
Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy	28
Eflornithine for treatment of high-risk neuroblastoma	28
The structure, function, and pharmacology of SK channel family	27
Neurofilament light chain as a biomarker of chemotherapy-induced peripheral neuropathy	27
Boosting CAR-T cell therapy through vaccine synergy	27
Visceral obesity and HFpEF: targets and therapeutic opportunities	26
Tackling chronic kidney disease in diabetic patients with finerenone	26
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Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges	25
Biologics and cardiac disease: challenges and opportunities	25
Magnesium for disease treatment and prevention: emerging mechanisms and opportunities	25
High-power screening (HPS) empowered by DNA-encoded libraries	25
Targeting plasma membrane cholesterol as a novel anticancer therapy	25
Targeting sensory neuron GPCRs for peripheral neuropathic pain	25
Harnessing associative learning paradigms to optimize drug treatment	25
Oteseconazole (VIVOJA) for prevention of recurrent vulvovaginal candidiasis	25
A novel anticancer pharmacological agent targeting mitochondrial complex I	24
Neutrophil extracellular traps in wound healing	24
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Challenges and opportunities associated with rare-variant pharmacogenomics	23
Recent advancements in vaccine research and development	23
Taming PRMT5–adaptor protein interactions	23
WEE-family kinases in cancer: synthetic lethal interactions and drug discovery	22
GABAA receptors as targets for treating affective and cognitive symptoms of depression	22
Crosstalk between androgen receptor and protein kinase G signaling in bone: implications for osteoporosis therapy	22
Multitargeting neuroimmune pathways: novel candidates for chronic pain relief	22
Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics	21
NLRP3 and pyroptosis blockers for treating inflammatory diseases	20
Circadian biology to advance therapeutics for mood disorders	20
Targeted protein degrader development for cancer: advances, challenges, and opportunities	19
Harnessing UBR5 for targeted protein degradation of key transcriptional regulators	19
Advisory Board and Contents	19
Glymphatic-stagnated edema induced by traumatic brain injury	19
Potential for targeting small heat shock protein modifications	19
The ABCs of psychedelics: a preclinical roadmap for drug discovery	19
The structure and function of YTHDF epitranscriptomic m6A readers	19
Odorant receptors as potential drug targets	19
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KRASG12C/mTORC1 inhibition: a powerful duo in NSCLC therapeutics	18
GPCR-dependent and -independent arrestin signaling	18
Malolactone strikes: K-Ras-G12D's Achilles' heel	18
Advisory Board and Contents	18
Bridging the gap in neuropsychiatric translational research	17
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Learning from natural design for local anesthetic delivery	17
Advisory Board and Contents	17
Hans Jürg Schatzmann (1924–2021)	17
Advisory Board and Contents	16
Celiac disease: mechanisms and emerging therapeutics	16
Targeting ion channel dysregulation in tumors: emerging therapeutic opportunities	16
Glaucoma: neuroprotection with NAD-based therapeutic interventions	16
Harnessing deep learning for enhanced ligand docking	16
Leveraging non-enzymatic functions of LSD1 for novel therapeutics	16
Advancing small-molecule drug discovery by encoded dual-display technologies	16
Electroceuticals: emerging applications beyond the nervous system and excitable tissues	16
Emerging epigenetic insights into aging mechanisms and interventions	15
Advisory Board and Contents	15

Mitochondrial dynamics proteins as emerging drug targets	15
Advisory Board and Contents	15
Thapsigargin: key to new host-directed coronavirus antivirals?	15
NET-targeted therapy: effects, limitations, and potential strategies to enhance treatment efficacy	15
Structural perspective of class B1 GPCR signaling	15
Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics	14
Targeting glycosylation to enhance tumor immunotherapy	14
Advisory Board and Contents	14
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Endometriosis: cannabidiol therapy for symptom relief	14
Fluorescent RNAs: new opportunities for drug discovery	14
Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation	14
Reactive chemistry for covalent probe and therapeutic development	14
Subtyping for pancreatic cancer precision therapy	14
Advisory Board and Contents	14
Current landscape of preclinical models of diabetic cardiomyopathy	13
Isoform-selective targeting of PI3K: time to consider new opportunities?	13
TNIK’s emerging role in cancer, metabolism, and age-related diseases	13
Pharmacological targeting of the tumor–immune symbiosis in glioblastoma	13
Multiple hERG channel blocking pathways: implications for macromolecules	13
At last: the mitochondrial pyruvate carrier structure revealed!	12
Advisory Board and Contents	12
IRAK4: potential therapeutic target for airway disease exacerbations	12
Recent breakthroughs and future directions in drugging aquaporins	12
Present and future of microglial pharmacology	12
A mechanism for ligand-dependent activation of AHR	12
Nanodelivery of cGAS-STING activators for tumor immunotherapy	12
Targeting chromosomal instability and aneuploidy in cancer	12
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Targeting galectin-3 in inflammatory and fibrotic diseases	12
Engineering extracellular vesicles for diagnosis and therapy	12
Photoswitchable allosteric and dualsteric ligands in GPCR pharmacology	11
Emerging mechanisms of psilocybin-induced neuroplasticity	11
Calcitonin/PAC1 receptor splice variants: a blind spot in migraine research	11
Unifying mechanism behind the onset of acquired epilepsy	11
Advisory Board and Contents	11
Casimersen for the treatment of Duchenne muscular dystrophy	11
Siglecs in immunotherapy: current clinical landscape and prospects	10
Mutations in muscle-type creatine kinase impact HIV prevention	10
Therapeutic targeting of exportin-1 beyond nuclear export	10
Neuron–tumor crosstalk fuels small cell lung cancer	10
Advisory Board and Contents	10
Heterobifunctional small molecules to modulate RNA function	10
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Structural snapshot of a β-arrestin-biased receptor	10
Giving ERK a jERK from the endosome	9
Repurposing trifluoperazine for glioblastoma treatment	9
VMAT structures reveal exciting targets for drug development	9
18F-Flurpiridaz PET for imaging of myocardial ischemia	9
Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads	9
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A quick guide to networking for scientists	9
Fezolinetant for menopausal hot flashes and night sweats	9
Targeting in silico GPCR conformations with ultra-large library screening for hit discovery	9
Copper homeostasis and cuproptosis in cardiovascular disease therapeutics	9
Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities	9
Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain	8
PPAR agonists for the treatment of neuroinflammatory diseases	8
Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development	8
Emerging paradigms and recent progress in targeting ErbB in cancers	8
The potential of long noncoding RNA therapies	8
Gut-derived brain T cells modulate behavior via IFN-γ	8
Beyond the blood–brain barrier: the fate of transcytosed therapeutics	8
Targeting neurological abnormalities in lysosomal storage diseases	8
The structure and function of olfactory receptors	8
Targeting TRPM channels for cerebral ischemia–reperfusion injury	8
Data and AI-driven synthetic binding protein discovery	7
ACK1/TNK2 kinase: molecular mechanisms and emerging cancer therapeutics	7
Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine	7
PSA inhibitors for contraception: insights from prostate cancer	7
Design and development of glucocorticoid receptor modulators	7
Potentiation of GPCR signaling by ATP and sugar monophosphates	7
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Some assembly required: a single-RNA vaccine against enterovirus-D68	7
Human carbonic anhydrase modulators: the past, present, and future	7
Emerging mechanisms and therapeutics in inflammatory muscle diseases	7
A decoy mutant ACE2 designed to reduce COVID-19	6
Enhancing oncogenic signaling to kill cancer cells	6
Protein–protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies	6
Pharmacogenomics in treatment of depression and psychosis: an update	6
Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment	6
Advances in cell therapy: progress and challenges in hematological and solid tumors	6
Chromosome-scale genomes throw light on plant drug biosynthesis	6
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Mutated G proteins as drug targets	6
Hypothalamic AMPK as a possible target for energy balance-related diseases	6
Targeting solute carriers to modulate receptor–ligand interactions	6
Targeting BRD4 bromodomains and beyond: exploring new therapeutic frontiers	6
Mitochondrial quality control: prime targets for antiviral therapy?	6
Glycine: a long-sought novel ligand for GPR158	6
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Targeting Fks1 proteins for novel antifungal drug discovery	6
Advisory Board and Contents	5
Ganaxolone for management of seizures associated with CDKL5 deficiency disorder	5
RH5 antigenic landscape shapes vaccine and antibody development	5