Trends in Pharmacological Sciences

Article	Citations
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Shearing of surface mucin saps tumor cell strength	550
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Advisory Board and Contents	236
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DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1	193
Structural asymmetry in FGF23 signaling	182
Advancing chemical carcinogenicity prediction modeling: opportunities and challenges	174
Cancer pathogenesis and phase targeting through condensate fragility	165
Monitoring neurodegeneration through brain-derived extracellular vesicles in biofluids	150
Compstatins: the dawn of clinical C3-targeted complement inhibition	143
Muscarinic receptors: from clinic to bench to clinic	138
Targeting complement in neurodegeneration: challenges, risks, and strategies	134
Ensifentrine (Ohtuvayre™) for chronic obstructive pulmonary disease	131
Therapeutic inhibition of ferroptosis in neurodegenerative disease	122
Structural pharmacology and mechanisms of GLP-1R signaling	109
Swinging the SWI/SNF complexes for cancer therapy	108
Direct in vivo CAR T cell engineering	104
Chemically modified neoantigen-based immunotherapy for targeting KRASG12C-driven tumors	103
Nemolizumab (Nemluvio®) for prurigo nodularis	103
Advisory Board and Contents	102
Engineering ACE2 decoy receptors to combat viral escapability	101
Leveraging human microbiomes for disease prediction and treatment	99

The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics	99
Optogenetic engineering for precision cancer immunotherapy	94
Programmable CAR immunotherapies for neurodegenerative proteinopathies	94
Phenotypic approaches for CNS drugs	91
Advisory Board and Contents	87
Mechanistic considerations for adenosine-lidocaine-magnesium (ALM) in controlling coagulopathy	86
Advisory Board and Contents	85
A deep dive into degrader-induced protein-protein interfaces	84
A perspective on psychedelic teratogenicity: the utility of zebrafish models	84
HSV-1 as a gene delivery platform for cancer gene therapy	83
A smart hospital-driven approach to precision pharmacovigilance	79
Ribosome-directed cancer therapies: the tip of the iceberg?	72
siRNA drug Leqvio (inclisiran) to lower cholesterol	70
Genetically engineered loaded extracellular vesicles for drug delivery	68
Close to a year in TIPS’ saddle – I am optimistic	67
Deubiquitinating enzymes as therapeutic targets in diabetic nephropathy	64
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Thriving as members of under-represented groups in pharmacology-related careers	64
Molecular glues evolve from serendipity to rational design	62
GPR35, ally of the anti-ischemic ATPIF1-ATP synthase interaction	59
Mentoring future science leaders to thrive	57
Emerging approaches to induce immune tolerance to therapeutic proteins	56
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Now you serine, now you don't	55
Bimetallic nanoadjuvants for cancer vaccines	54
Targeting AMPK as a potential treatment for hepatic fibrosis in MASLD	54
Selective tyrosine kinase 2 inhibitors in inflammatory bowel disease	53
Piezo1: structural pharmacology and mechanotransduction mechanisms	52
The structure, function, and pharmacology of MRGPRs	51
Autologous, allogeneic, in vivo CAR for autoimmune diseases	49
Suzetrigine for moderate to severe acute pain	49
Could dexmedetomidine be repurposed as a glymphatic enhancer?	48
Alzheimer’s therapeutic development: shifting neurodegeneration to neuroregeneration	45
Advancing non-destructive analysis of 3D printed medicines	43
The promise of targeted protein degradation approaches	42
The road less traveled: activating an oncogenic kinase	42
Advisory Board and Contents	42
Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease	41
Targeting metabolic vulnerabilities with advanced delivery systems	41
Treg-directed cancer immunotherapy beyond immune checkpoints: progress and opportunities	40
Inhalable neutralizing antibodies – promising approach to combating respiratory viral infections	40
Salt-inducible kinases: new players in pulmonary arterial hypertension?	40
Targeting LKB1/STK11-mutant cancer: distinct metabolism, microenvironment, and therapeutic resistance	39
Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients	38
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The end of the beginning in understanding SLC22 polyspecificity	37
A novel function of the M2 muscarinic receptor	37
Promising neuroimmune targets and drugs for CNS diseases	37
Advisory Board and Contents	37

Beyond G protein and arrestin: GRK2-biased β₂AR signaling	36
Validation of agent-based models of surface receptor oligomerisation	36
Frizzleds act as dynamic pharmacological entities	35
Artificial intelligence in rare diseases: toward clinical impact	35
PDE4 modulates muscle signaling in cancer cachexia	35
Targeting the assembly of biomolecules: condensate-based drug discovery	34
Monkeypox: potential vaccine development strategies	34
BTK inhibitors: past, present, and future	33
Decoding pseudouridine: an emerging target for therapeutic development	33
GPR35: from enigma to therapeutic target	31
Protein acylations in cancer immunity: effects and therapeutic opportunities	31
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Advisory Board and Contents	31
Tackling microbial iron homeostasis: novel antimicrobial strategies	31
Eflornithine for treatment of high-risk neuroblastoma	30
SEAKER cells coordinate cellular immunotherapy with localized chemotherapy	30
Advisory Board and Contents	30
Development of PROTACs using computational approaches	29
Neurofilament light chain as a biomarker of chemotherapy-induced peripheral neuropathy	29
Topical difamilast for the treatment of mild-to-moderate atopic dermatitis	29
Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy	28
Demographic diversity in platelet function and response to antiplatelet therapy	28
Voltage-gated ion channels in epilepsies: circuit dysfunctions and treatments	28
Metabolic regulation in normal and leukemic stem cells	27
Circulating tumor cells in precision medicine: challenges and opportunities	27
Recent advances in generative biology for biotherapeutic discovery	27
Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges	26
Biologics and cardiac disease: challenges and opportunities	26
Targeting plasma membrane cholesterol as a novel anticancer therapy	26
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The structure, function, and pharmacology of SK channel family	26
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Tackling chronic kidney disease in diabetic patients with finerenone	25
A novel anticancer pharmacological agent targeting mitochondrial complex I	25
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Harnessing associative learning paradigms to optimize drug treatment	24
Visceral obesity and HFpEF: targets and therapeutic opportunities	24
Boosting CAR-T cell therapy through vaccine synergy	24
Oteseconazole (VIVOJA) for prevention of recurrent vulvovaginal candidiasis	24
Magnesium for disease treatment and prevention: emerging mechanisms and opportunities	23
Targeting sensory neuron GPCRs for peripheral neuropathic pain	23
Neutrophil extracellular traps in wound healing	23
Recent advancements in vaccine research and development	23
Challenges and opportunities associated with rare-variant pharmacogenomics	22
The ABCs of psychedelics: a preclinical roadmap for drug discovery	22
Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics	22
Multitargeting neuroimmune pathways: novel candidates for chronic pain relief	22
Circadian biology to advance therapeutics for mood disorders	22
Taming PRMT5–adaptor protein interactions	22
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Therapeutic antibodies targeting G protein-coupled receptors	22
WEE-family kinases in cancer: synthetic lethal interactions and drug discovery	22
Crosstalk between androgen receptor and protein kinase G signaling in bone: implications for osteoporosis therapy	21
GABAA receptors as targets for treating affective and cognitive symptoms of depression	21
NLRP3 and pyroptosis blockers for treating inflammatory diseases	21
Advisory Board and Contents	20
Harnessing UBR5 for targeted protein degradation of key transcriptional regulators	20
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Odorant receptors as potential drug targets	20
Targeting peptide–HLA complexes for precision immunotherapy	19
GPCR-dependent and -independent arrestin signaling	19
Potential for targeting small heat shock protein modifications	19
β-Arrestins and disease-linked variants: opportunities for targeted modulation	19
Glymphatic-stagnated edema induced by traumatic brain injury	19
Advisory Board and Contents	18
Bridging the gap in neuropsychiatric translational research	18
Celiac disease: mechanisms and emerging therapeutics	18
Targeted protein degrader development for cancer: advances, challenges, and opportunities	18
Malolactone strikes: K-Ras-G12D's Achilles' heel	18
Advisory Board and Contents	18
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The structure and function of YTHDF epitranscriptomic m6A readers	18
KRASG12C/mTORC1 inhibition: a powerful duo in NSCLC therapeutics	18
Advisory Board and Contents	18
Induced proximity for dephosphorylation	17
Glaucoma: neuroprotection with NAD-based therapeutic interventions	17
Drugging cold-response networks for neuroprotection	17
NET-targeted therapy: effects, limitations, and potential strategies to enhance treatment efficacy	17
Targeting ion channel dysregulation in tumors: emerging therapeutic opportunities	17
Mitochondrial dynamics proteins as emerging drug targets	16

Leveraging non-enzymatic functions of LSD1 for novel therapeutics	16
Electroceuticals: emerging applications beyond the nervous system and excitable tissues	16
Emerging epigenetic insights into aging mechanisms and interventions	16
Thapsigargin: key to new host-directed coronavirus antivirals?	16
Advisory Board and Contents	15
Harnessing deep learning for enhanced ligand docking	15
Multiple hERG channel blocking pathways: implications for macromolecules	15
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Advancing small-molecule drug discovery by encoded dual-display technologies	15
Advisory Board and Contents	15
Advisory Board and Contents	15
Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation	14
Subtyping for pancreatic cancer precision therapy	14
Current landscape of preclinical models of diabetic cardiomyopathy	14
Nanodelivery of cGAS-STING activators for tumor immunotherapy	14
Endometriosis: cannabidiol therapy for symptom relief	14
Fluorescent RNAs: new opportunities for drug discovery	14
Isoform-selective targeting of PI3K: time to consider new opportunities?	14
Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics	14
Targeting glycosylation to enhance tumor immunotherapy	14
Targeting galectin-3 in inflammatory and fibrotic diseases	14
Pharmacological targeting of the tumor–immune symbiosis in glioblastoma	14
At last: the mitochondrial pyruvate carrier structure revealed!	13
Targeting the senescence–autophagy axis for idiopathic pulmonary fibrosis therapy	13
Targeting chromosomal instability and aneuploidy in cancer	13
Engineering extracellular vesicles for diagnosis and therapy	13
TNIK’s emerging role in cancer, metabolism, and age-related diseases	13
A mechanism for ligand-dependent activation of AHR	13
Advisory Board and Contents	13
Present and future of microglial pharmacology	13
Calcitonin/PAC1 receptor splice variants: a blind spot in migraine research	12
Emerging mechanisms of psilocybin-induced neuroplasticity	12
Click chemistry charts covalent drug landscapes in vivo	12
Photoswitchable allosteric and dualsteric ligands in GPCR pharmacology	12
Small molecule modulation of organelle membrane contact sites	12
IRAK4: potential therapeutic target for airway disease exacerbations	12
Advisory Board and Contents	12
Casimersen for the treatment of Duchenne muscular dystrophy	12
Giving ERK a jERK from the endosome	11
18F-Flurpiridaz PET for imaging of myocardial ischemia	11
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Targeting the sensory–sympathetic axis for cancer immunotherapy	11
Advisory Board and Contents	11
Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities	10
Repurposing trifluoperazine for glioblastoma treatment	10
Heterobifunctional small molecules to modulate RNA function	10
Siglecs in immunotherapy: current clinical landscape and prospects	10
Therapeutic targeting of exportin-1 beyond nuclear export	10
February 2026 issue first authors	10
Neuron–tumor crosstalk fuels small cell lung cancer	10
Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads	10
Targeting in silico GPCR conformations with ultra-large library screening for hit discovery	10
Structural snapshot of a β-arrestin-biased receptor	10
March 2026 issue first authors	9
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A quick guide to networking for scientists	9
Copper homeostasis and cuproptosis in cardiovascular disease therapeutics	9
Targeting neurological abnormalities in lysosomal storage diseases	9
VMAT structures reveal exciting targets for drug development	9
Fezolinetant for menopausal hot flashes and night sweats	9
Targeting TRPM channels for cerebral ischemia–reperfusion injury	8
Beyond the blood–brain barrier: the fate of transcytosed therapeutics	8
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Design and development of glucocorticoid receptor modulators	8
Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development	8
Gut-derived brain T cells modulate behavior via IFN-γ	8
Potentiation of GPCR signaling by ATP and sugar monophosphates	8
PSA inhibitors for contraception: insights from prostate cancer	8
PPAR agonists for the treatment of neuroinflammatory diseases	8
Emerging paradigms and recent progress in targeting ErbB in cancers	8
The structure and function of olfactory receptors	8
Data and AI-driven synthetic binding protein discovery	8
Leveraging spatial omics for the development of precision sarcoma treatments	7
Some assembly required: a single-RNA vaccine against enterovirus-D68	7
ACK1/TNK2 kinase: molecular mechanisms and emerging cancer therapeutics	7
Targeting solute carriers to modulate receptor–ligand interactions	7
A decoy mutant ACE2 designed to reduce COVID-19	7
Human carbonic anhydrase modulators: the past, present, and future	7
Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine	7
Emerging mechanisms and therapeutics in inflammatory muscle diseases	7
Advances in cell therapy: progress and challenges in hematological and solid tumors	7
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Targeting Fks1 proteins for novel antifungal drug discovery	7
Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment	7
Hypothalamic AMPK as a possible target for energy balance-related diseases	7
Enhancing oncogenic signaling to kill cancer cells	7
Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity	6
Formyl peptide receptors as therapeutic targets in eye disease	6
Leveraging conformational ensembles in allosteric drug discovery	6
FOXO transcription factors as therapeutic targets in human diseases	6
Shining light on parvalbumin interneuron plasticity	6
How can quantum computing be applied in clinical trial design and optimization?	6
Advisory Board and Contents	6
Advisory Board and Contents	6