Trends in Pharmacological Sciences

Article	Citations
Subscription and Copyright Information	730
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Ensifentrine (Ohtuvayre™) for chronic obstructive pulmonary disease	296
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Advisory Board and Contents	167
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DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1	152
Muscarinic receptors: from clinic to bench to clinic	145
Shearing of surface mucin saps tumor cell strength	141
Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism	129
Monitoring neurodegeneration through brain-derived extracellular vesicles in biofluids	116
Peptides as a therapeutic strategy against Klebsiella pneumoniae	113
Advancing chemical carcinogenicity prediction modeling: opportunities and challenges	110
Structural asymmetry in FGF23 signaling	108
Targeting complement in neurodegeneration: challenges, risks, and strategies	101
Structural pharmacology and mechanisms of GLP-1R signaling	98
Compstatins: the dawn of clinical C3-targeted complement inhibition	93
Therapeutic inhibition of ferroptosis in neurodegenerative disease	93
Direct in vivo CAR T cell engineering	91
Advisory Board and Contents	85
Advisory Board and Contents	82
Phenotypic approaches for CNS drugs	82
Chemically modified neoantigen-based immunotherapy for targeting KRASG12C-driven tumors	82
A smart hospital-driven approach to precision pharmacovigilance	78

Advisory Board and Contents	74
A deep dive into degrader-induced protein-protein interfaces	72
Optogenetic engineering for precision cancer immunotherapy	71
HSV-1 as a gene delivery platform for cancer gene therapy	68
siRNA drug Leqvio (inclisiran) to lower cholesterol	68
Mechanistic considerations for adenosine-lidocaine-magnesium (ALM) in controlling coagulopathy	62
A perspective on psychedelic teratogenicity: the utility of zebrafish models	61
Liquid–liquid phase separation: a principal organizer of the cell’s biochemical activity architecture	60
Ribosome-directed cancer therapies: the tip of the iceberg?	60
Genetically engineered loaded extracellular vesicles for drug delivery	59
Engineering ACE2 decoy receptors to combat viral escapability	59
Leveraging human microbiomes for disease prediction and treatment	59
Emerging strategies for beta cell transplantation to treat diabetes	58
Advisory Board and Contents	58
Targeting AMPK as a potential treatment for hepatic fibrosis in MASLD	57
Could dexmedetomidine be repurposed as a glymphatic enhancer?	56
Suzetrigine for moderate to severe acute pain	56
Close to a year in TIPS’ saddle – I am optimistic	55
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Thriving as members of under-represented groups in pharmacology-related careers	53
Lipoxygenases in chronic liver diseases: current insights and future perspectives	51
Mentoring future science leaders to thrive	50
GPR35, ally of the anti-ischemic ATPIF1-ATP synthase interaction	50
Emerging approaches to induce immune tolerance to therapeutic proteins	49
Selective tyrosine kinase 2 inhibitors in inflammatory bowel disease	48
The structure, function, and pharmacology of MRGPRs	48
Alzheimer’s therapeutic development: shifting neurodegeneration to neuroregeneration	47
Advancing non-destructive analysis of 3D printed medicines	47
Advisory Board and Contents	47
Building unconventional G protein-coupled receptors, one block at a time	46
The promise of targeted protein degradation approaches	46
Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients	45
Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease	44
Salt-inducible kinases: new players in pulmonary arterial hypertension?	42
Inhalable neutralizing antibodies – promising approach to combating respiratory viral infections	40
Fragment-based drug design facilitates selective kinase inhibitor discovery	40
The road less traveled: activating an oncogenic kinase	40
Promising neuroimmune targets and drugs for CNS diseases	40
Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension	40
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Advisory Board and Contents	39
The end of the beginning in understanding SLC22 polyspecificity	38
Frizzleds act as dynamic pharmacological entities	38
A novel function of the M2 muscarinic receptor	38
Validation of agent-based models of surface receptor oligomerisation	37
Nanocarriers for oral delivery of biologics: small carriers for big payloads	36
Protein acylations in cancer immunity: effects and therapeutic opportunities	36
Targeting intracellular protein–protein interactions with macrocyclic peptides	35
BTK inhibitors: past, present, and future	34
Monkeypox: potential vaccine development strategies	34

Advisory Board and Contents	33
Decoding pseudouridine: an emerging target for therapeutic development	33
Metabolic regulation in normal and leukemic stem cells	33
Demographic diversity in platelet function and response to antiplatelet therapy	32
Neurofilament light chain as a biomarker of chemotherapy-induced peripheral neuropathy	32
Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches	32
SEAKER cells coordinate cellular immunotherapy with localized chemotherapy	32
GPR35: from enigma to therapeutic target	31
Recent advances in generative biology for biotherapeutic discovery	31
Circulating tumor cells in precision medicine: challenges and opportunities	30
Development of PROTACs using computational approaches	30
Eflornithine for treatment of high-risk neuroblastoma	29
Intra- and intercellular signaling pathways associated with drug-induced cardiac pathophysiology	28
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Tackling chronic kidney disease in diabetic patients with finerenone	28
Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy	28
Engineered antibody fusion proteins for targeted disease therapy	28
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Voltage-gated ion channels in epilepsies: circuit dysfunctions and treatments	28
Visceral obesity and HFpEF: targets and therapeutic opportunities	27
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Harnessing associative learning paradigms to optimize drug treatment	27
A novel anticancer pharmacological agent targeting mitochondrial complex I	27
Biochemical perspectives on targeting KMT2 methyltransferases in cancer	26
Targeting plasma membrane cholesterol as a novel anticancer therapy	26
Boosting CAR-T cell therapy through vaccine synergy	25
Targeting sensory neuron GPCRs for peripheral neuropathic pain	25
Magnesium for disease treatment and prevention: emerging mechanisms and opportunities	25
Commemorating insulin's centennial: engineering insulin pharmacology towards physiology	25
High-power screening (HPS) empowered by DNA-encoded libraries	25
Oteseconazole (VIVOJA) for prevention of recurrent vulvovaginal candidiasis	25
Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges	24
Biologics and cardiac disease: challenges and opportunities	24
Neutrophil extracellular traps in wound healing	24
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Crosstalk between androgen receptor and protein kinase G signaling in bone: implications for osteoporosis therapy	23
Taming PRMT5–adaptor protein interactions	23
Teaching an old dog new tricks: repurposing β-lactams	23
Recent advancements in vaccine research and development	23
Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity	23
Challenges and opportunities associated with rare-variant pharmacogenomics	22
GABAA receptors as targets for treating affective and cognitive symptoms of depression	21
Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics	21
Circadian biology to advance therapeutics for mood disorders	21
NLRP3 and pyroptosis blockers for treating inflammatory diseases	20
Partial agonists go molecular	20
Odorant receptors as potential drug targets	20
Advisory Board and Contents	20
Microfluidic technologies for drug discovery and development: friend or foe?	20
Potential for targeting small heat shock protein modifications	20
Membrane protein production and formulation for drug discovery	20
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GPCR-dependent and -independent arrestin signaling	19
Targeted protein degrader development for cancer: advances, challenges, and opportunities	18
Hans Jürg Schatzmann (1924–2021)	18
Glymphatic-stagnated edema induced by traumatic brain injury	18
Advisory Board and Contents	18
Harnessing UBR5 for targeted protein degradation of key transcriptional regulators	18
Advisory Board and Contents	18
The structure and function of YTHDF epitranscriptomic m6A readers	18
Bridging the gap in neuropsychiatric translational research	17
Celiac disease: mechanisms and emerging therapeutics	17
KRASG12C/mTORC1 inhibition: a powerful duo in NSCLC therapeutics	17
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Leveraging non-enzymatic functions of LSD1 for novel therapeutics	17
Thapsigargin: key to new host-directed coronavirus antivirals?	16
Screening strategies for identifying RNA- and ribonucleoprotein-targeted compounds	16
Structural perspective of class B1 GPCR signaling	16
Learning from natural design for local anesthetic delivery	16
Electroceuticals: emerging applications beyond the nervous system and excitable tissues	16
Glaucoma: neuroprotection with NAD-based therapeutic interventions	16
Malolactone strikes: K-Ras-G12D's Achilles' heel	16
Harnessing deep learning for enhanced ligand docking	16
Mitochondrial dynamics proteins as emerging drug targets	15
Advisory Board and Contents	15
NET-targeted therapy: effects, limitations, and potential strategies to enhance treatment efficacy	15
Advancing small-molecule drug discovery by encoded dual-display technologies	15
Emerging epigenetic insights into aging mechanisms and interventions	15
Apart, together: reflections on the COVID-19 pandemic	15
Subtyping for pancreatic cancer precision therapy	14

Safety of medicines and vaccines – building next generation capability	14
Advisory Board and Contents	14
Fluorescent RNAs: new opportunities for drug discovery	14
Advisory Board and Contents	14
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Multiple hERG channel blocking pathways: implications for macromolecules	14
Advisory Board and Contents	14
Advisory Board and Contents	14
Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation	13
Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics	13
Current landscape of preclinical models of diabetic cardiomyopathy	13
Pharmacological targeting of the tumor–immune symbiosis in glioblastoma	13
Isoform-selective targeting of PI3K: time to consider new opportunities?	13
Reactive chemistry for covalent probe and therapeutic development	13
Advisory Board and Contents	13
Endometriosis: cannabidiol therapy for symptom relief	13
Advisory Board and Contents	12
Engineering extracellular vesicles for diagnosis and therapy	12
TNIK’s emerging role in cancer, metabolism, and age-related diseases	12
Targeting chromosomal instability and aneuploidy in cancer	12
Advisory Board and Contents	12
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Present and future of microglial pharmacology	12
At last: the mitochondrial pyruvate carrier structure revealed!	12
A mechanism for ligand-dependent activation of AHR	12
Targeting galectin-3 in inflammatory and fibrotic diseases	12
Nanodelivery of cGAS-STING activators for tumor immunotherapy	12
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Recent breakthroughs and future directions in drugging aquaporins	12
Targeting sialylation to treat central nervous system diseases	12
Calcitonin/PAC1 receptor splice variants: a blind spot in migraine research	11
IRAK4: potential therapeutic target for airway disease exacerbations	11
Unifying mechanism behind the onset of acquired epilepsy	11
Paving the way for designing drugs targeting TMEM16A	11
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Fezolinetant for menopausal hot flashes and night sweats	10
In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target	10
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Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads	10
Advisory Board and Contents	10
Casimersen for the treatment of Duchenne muscular dystrophy	10
Structural snapshot of a β-arrestin-biased receptor	10
Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities	9
A quick guide to networking for scientists	9
Targeting in silico GPCR conformations with ultra-large library screening for hit discovery	9
Giving ERK a jERK from the endosome	9
Therapeutic targeting of exportin-1 beyond nuclear export	9
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VMAT structures reveal exciting targets for drug development	9
Mutations in muscle-type creatine kinase impact HIV prevention	9
Heterobifunctional small molecules to modulate RNA function	9
Copper homeostasis and cuproptosis in cardiovascular disease therapeutics	9
Targeting neurological abnormalities in lysosomal storage diseases	9
Iron metabolism: pathophysiology and pharmacology	9
Repurposing trifluoperazine for glioblastoma treatment	9
Targeting TRPM channels for cerebral ischemia–reperfusion injury	8
Cholesterol – the devil you know; ceramide – the devil you don’t	8
Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain	8
Emerging paradigms and recent progress in targeting ErbB in cancers	8
The potential of long noncoding RNA therapies	8
Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development	8
Current views on N-glycolylneuraminic acid in therapeutic recombinant proteins	7
Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine	7
Some assembly required: a single-RNA vaccine against enterovirus-D68	7
The structure and function of olfactory receptors	7
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Targeting the mitochondrial chaperone TRAP1: strategies and therapeutic perspectives	7
Advances in cell therapy: progress and challenges in hematological and solid tumors	7
PPAR agonists for the treatment of neuroinflammatory diseases	7
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ACK1/TNK2 kinase: molecular mechanisms and emerging cancer therapeutics	7
Hypothalamic AMPK as a possible target for energy balance-related diseases	6
Targeting Fks1 proteins for novel antifungal drug discovery	6
A decoy mutant ACE2 designed to reduce COVID-19	6
Leveraging spatial omics for the development of precision sarcoma treatments	6
Emerging mechanisms and therapeutics in inflammatory muscle diseases	6
PSA inhibitors for contraception: insights from prostate cancer	6
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Data and AI-driven synthetic binding protein discovery	6
Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment	6
Targeting solute carriers to modulate receptor–ligand interactions	6
Chromosome-scale genomes throw light on plant drug biosynthesis	6
FOXO transcription factors as therapeutic targets in human diseases	5
Advisory Board and Contents	5
Emerging approaches for antagonizing the aryl hydrocarbon receptor	5
Glycine: a long-sought novel ligand for GPR158	5
Protein–protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies	5
The future of neuroimmunology research for CNS disease therapeutics	5
Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity	5
How can quantum computing be applied in clinical trial design and optimization?	5
Mitochondrial quality control: prime targets for antiviral therapy?	5
Advisory Board and Contents	5
Efferocytosis in inflammatory bone disorders	5