Trends in Pharmacological Sciences

Article	Citations
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Structural pharmacology and mechanisms of GLP-1R signaling	526
Subscription and Copyright Information	373
DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1	212
Shearing of surface mucin saps tumor cell strength	205
Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism	186
Advancing chemical carcinogenicity prediction modeling: opportunities and challenges	176
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Muscarinic receptors: from clinic to bench to clinic	146
Structural asymmetry in FGF23 signaling	141
Advisory Board and Contents	133
Subscription and Copyright Information	122
Compstatins: the dawn of clinical C3-targeted complement inhibition	116
Direct in vivo CAR T cell engineering	113
Monitoring neurodegeneration through brain-derived extracellular vesicles in biofluids	112
Swinging the SWI/SNF complexes for cancer therapy	108
Ensifentrine (Ohtuvayre™) for chronic obstructive pulmonary disease	104
Targeting complement in neurodegeneration: challenges, risks, and strategies	102
Therapeutic inhibition of ferroptosis in neurodegenerative disease	101
Peptides as a therapeutic strategy against Klebsiella pneumoniae	94
Phenotypic approaches for CNS drugs	90
Ribosome-directed cancer therapies: the tip of the iceberg?	86
Advisory Board and Contents	81
The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics	81

Chemically modified neoantigen-based immunotherapy for targeting KRASG12C-driven tumors	81
Nemolizumab (Nemluvio®) for prurigo nodularis	78
siRNA drug Leqvio (inclisiran) to lower cholesterol	76
A deep dive into degrader-induced protein-protein interfaces	75
Mechanistic considerations for adenosine-lidocaine-magnesium (ALM) in controlling coagulopathy	74
Advisory Board and Contents	72
A perspective on psychedelic teratogenicity: the utility of zebrafish models	69
A smart hospital-driven approach to precision pharmacovigilance	68
Engineering ACE2 decoy receptors to combat viral escapability	66
Advisory Board and Contents	66
Genetically engineered loaded extracellular vesicles for drug delivery	63
Leveraging human microbiomes for disease prediction and treatment	63
Optogenetic engineering for precision cancer immunotherapy	63
Emerging strategies for beta cell transplantation to treat diabetes	63
HSV-1 as a gene delivery platform for cancer gene therapy	62
Liquid–liquid phase separation: a principal organizer of the cell’s biochemical activity architecture	61
Close to a year in TIPS’ saddle – I am optimistic	60
Suzetrigine for moderate to severe acute pain	60
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Deubiquitinating enzymes as therapeutic targets in diabetic nephropathy	54
Bimetallic nanoadjuvants for cancer vaccines	52
Piezo1: structural pharmacology and mechanotransduction mechanisms	52
Advancing non-destructive analysis of 3D printed medicines	51
Advisory Board and Contents	51
Alzheimer’s therapeutic development: shifting neurodegeneration to neuroregeneration	50
Could dexmedetomidine be repurposed as a glymphatic enhancer?	47
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Selective tyrosine kinase 2 inhibitors in inflammatory bowel disease	46
Lipoxygenases in chronic liver diseases: current insights and future perspectives	46
Mentoring future science leaders to thrive	44
Emerging approaches to induce immune tolerance to therapeutic proteins	44
Thriving as members of under-represented groups in pharmacology-related careers	43
The structure, function, and pharmacology of MRGPRs	43
Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients	42
Targeting AMPK as a potential treatment for hepatic fibrosis in MASLD	42
GPR35, ally of the anti-ischemic ATPIF1-ATP synthase interaction	42
Advisory Board and Contents	41
The promise of targeted protein degradation approaches	41
Targeting LKB1/STK11-mutant cancer: distinct metabolism, microenvironment, and therapeutic resistance	41
The road less traveled: activating an oncogenic kinase	39
Salt-inducible kinases: new players in pulmonary arterial hypertension?	38
A novel function of the M2 muscarinic receptor	37
Inhalable neutralizing antibodies – promising approach to combating respiratory viral infections	37
Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease	37
Tackling microbial iron homeostasis: novel antimicrobial strategies	36
Protein acylations in cancer immunity: effects and therapeutic opportunities	36
Beyond G protein and arrestin: GRK2-biased β₂AR signaling	36
Frizzleds act as dynamic pharmacological entities	35
BTK inhibitors: past, present, and future	35
Advisory Board and Contents	34

Monkeypox: potential vaccine development strategies	34
Validation of agent-based models of surface receptor oligomerisation	34
Promising neuroimmune targets and drugs for CNS diseases	33
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Targeting intracellular protein–protein interactions with macrocyclic peptides	32
The end of the beginning in understanding SLC22 polyspecificity	32
Decoding pseudouridine: an emerging target for therapeutic development	32
Nanocarriers for oral delivery of biologics: small carriers for big payloads	32
Advisory Board and Contents	32
Neurofilament light chain as a biomarker of chemotherapy-induced peripheral neuropathy	31
Metabolic regulation in normal and leukemic stem cells	31
SEAKER cells coordinate cellular immunotherapy with localized chemotherapy	30
Demographic diversity in platelet function and response to antiplatelet therapy	30
Eflornithine for treatment of high-risk neuroblastoma	30
Recent advances in generative biology for biotherapeutic discovery	30
Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches	30
Voltage-gated ion channels in epilepsies: circuit dysfunctions and treatments	29
Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy	28
GPR35: from enigma to therapeutic target	28
Circulating tumor cells in precision medicine: challenges and opportunities	28
Development of PROTACs using computational approaches	28
Visceral obesity and HFpEF: targets and therapeutic opportunities	27
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Engineered antibody fusion proteins for targeted disease therapy	27
Magnesium for disease treatment and prevention: emerging mechanisms and opportunities	27
Targeting plasma membrane cholesterol as a novel anticancer therapy	27
Boosting CAR-T cell therapy through vaccine synergy	27
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Neutrophil extracellular traps in wound healing	25
Harnessing associative learning paradigms to optimize drug treatment	25
Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges	25
Biologics and cardiac disease: challenges and opportunities	25
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High-power screening (HPS) empowered by DNA-encoded libraries	25
Oteseconazole (VIVOJA) for prevention of recurrent vulvovaginal candidiasis	25
Tackling chronic kidney disease in diabetic patients with finerenone	25
A novel anticancer pharmacological agent targeting mitochondrial complex I	24
Recent advancements in vaccine research and development	24
Targeting sensory neuron GPCRs for peripheral neuropathic pain	24
Multitargeting neuroimmune pathways: novel candidates for chronic pain relief	23
Crosstalk between androgen receptor and protein kinase G signaling in bone: implications for osteoporosis therapy	23
The ABCs of psychedelics: a preclinical roadmap for drug discovery	23
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Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics	22
Taming PRMT5–adaptor protein interactions	22
Circadian biology to advance therapeutics for mood disorders	21
Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity	21
Challenges and opportunities associated with rare-variant pharmacogenomics	21
GABAA receptors as targets for treating affective and cognitive symptoms of depression	20
Potential for targeting small heat shock protein modifications	20
NLRP3 and pyroptosis blockers for treating inflammatory diseases	20
GPCR-dependent and -independent arrestin signaling	19
Glymphatic-stagnated edema induced by traumatic brain injury	19
Odorant receptors as potential drug targets	19
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Harnessing UBR5 for targeted protein degradation of key transcriptional regulators	19
Advisory Board and Contents	18
Targeted protein degrader development for cancer: advances, challenges, and opportunities	18
KRASG12C/mTORC1 inhibition: a powerful duo in NSCLC therapeutics	18
The structure and function of YTHDF epitranscriptomic m6A readers	18
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Advisory Board and Contents	18
Malolactone strikes: K-Ras-G12D's Achilles' heel	18
Learning from natural design for local anesthetic delivery	17
Emerging epigenetic insights into aging mechanisms and interventions	17
Hans Jürg Schatzmann (1924–2021)	17
Thapsigargin: key to new host-directed coronavirus antivirals?	17
Leveraging non-enzymatic functions of LSD1 for novel therapeutics	17
Harnessing deep learning for enhanced ligand docking	16
Electroceuticals: emerging applications beyond the nervous system and excitable tissues	16
Advancing small-molecule drug discovery by encoded dual-display technologies	16
Advisory Board and Contents	16
NET-targeted therapy: effects, limitations, and potential strategies to enhance treatment efficacy	16
Bridging the gap in neuropsychiatric translational research	16
Structural perspective of class B1 GPCR signaling	16
Glaucoma: neuroprotection with NAD-based therapeutic interventions	16
Advisory Board and Contents	15
Fluorescent RNAs: new opportunities for drug discovery	15
Advisory Board and Contents	15
Mitochondrial dynamics proteins as emerging drug targets	15

Advisory Board and Contents	15
Endometriosis: cannabidiol therapy for symptom relief	15
Advisory Board and Contents	15
Celiac disease: mechanisms and emerging therapeutics	15
Multiple hERG channel blocking pathways: implications for macromolecules	15
Targeting glycosylation to enhance tumor immunotherapy	15
Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation	14
Reactive chemistry for covalent probe and therapeutic development	14
Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics	14
Apart, together: reflections on the COVID-19 pandemic	14
Current landscape of preclinical models of diabetic cardiomyopathy	14
Isoform-selective targeting of PI3K: time to consider new opportunities?	14
Advisory Board and Contents	14
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Subtyping for pancreatic cancer precision therapy	14
Safety of medicines and vaccines – building next generation capability	14
Engineering extracellular vesicles for diagnosis and therapy	13
Present and future of microglial pharmacology	13
Targeting galectin-3 in inflammatory and fibrotic diseases	13
A mechanism for ligand-dependent activation of AHR	13
Nanodelivery of cGAS-STING activators for tumor immunotherapy	13
Targeting chromosomal instability and aneuploidy in cancer	13
Pharmacological targeting of the tumor–immune symbiosis in glioblastoma	13
Recent breakthroughs and future directions in drugging aquaporins	13
At last: the mitochondrial pyruvate carrier structure revealed!	13
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Photoswitchable allosteric and dualsteric ligands in GPCR pharmacology	12
Advisory Board and Contents	12
TNIK’s emerging role in cancer, metabolism, and age-related diseases	12
Unifying mechanism behind the onset of acquired epilepsy	12
Targeting sialylation to treat central nervous system diseases	12
Emerging mechanisms of psilocybin-induced neuroplasticity	12
IRAK4: potential therapeutic target for airway disease exacerbations	12
Casimersen for the treatment of Duchenne muscular dystrophy	11
Paving the way for designing drugs targeting TMEM16A	11
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Advisory Board and Contents	11
Calcitonin/PAC1 receptor splice variants: a blind spot in migraine research	11
Repurposing trifluoperazine for glioblastoma treatment	10
18F-Flurpiridaz PET for imaging of myocardial ischemia	10
Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads	10
Heterobifunctional small molecules to modulate RNA function	10
Targeting in silico GPCR conformations with ultra-large library screening for hit discovery	10
Advisory Board and Contents	10
Structural snapshot of a β-arrestin-biased receptor	10
Advisory Board and Contents	10
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Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities	9
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Giving ERK a jERK from the endosome	9
Fezolinetant for menopausal hot flashes and night sweats	9
Mutations in muscle-type creatine kinase impact HIV prevention	9
Copper homeostasis and cuproptosis in cardiovascular disease therapeutics	9
A quick guide to networking for scientists	8
Emerging paradigms and recent progress in targeting ErbB in cancers	8
Therapeutic targeting of exportin-1 beyond nuclear export	8
Targeting neurological abnormalities in lysosomal storage diseases	8
Cholesterol – the devil you know; ceramide – the devil you don’t	8
VMAT structures reveal exciting targets for drug development	8
Current views on N-glycolylneuraminic acid in therapeutic recombinant proteins	8
Targeting TRPM channels for cerebral ischemia–reperfusion injury	8
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Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development	7
PPAR agonists for the treatment of neuroinflammatory diseases	7
Beyond the blood–brain barrier: the fate of transcytosed therapeutics	7
The potential of long noncoding RNA therapies	7
Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain	7
Advances in cell therapy: progress and challenges in hematological and solid tumors	7
The structure and function of olfactory receptors	7
Gut-derived brain T cells modulate behavior via IFN-γ	6
PSA inhibitors for contraception: insights from prostate cancer	6
Human carbonic anhydrase modulators: the past, present, and future	6
Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine	6
Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment	6
ACK1/TNK2 kinase: molecular mechanisms and emerging cancer therapeutics	6
Some assembly required: a single-RNA vaccine against enterovirus-D68	6
Data and AI-driven synthetic binding protein discovery	6
Targeting Fks1 proteins for novel antifungal drug discovery	6
Targeting solute carriers to modulate receptor–ligand interactions	6
Design and development of glucocorticoid receptor modulators	6
Emerging mechanisms and therapeutics in inflammatory muscle diseases	6
Potentiation of GPCR signaling by ATP and sugar monophosphates	6
Hypothalamic AMPK as a possible target for energy balance-related diseases	6
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A decoy mutant ACE2 designed to reduce COVID-19	5
Shining light on parvalbumin interneuron plasticity	5
Ganaxolone for management of seizures associated with CDKL5 deficiency disorder	5
Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity	5
Glycine: a long-sought novel ligand for GPR158	5
The future of neuroimmunology research for CNS disease therapeutics	5
Advisory Board and Contents	5
Targeting mitochondrial dynamics and redox regulation in cardiovascular diseases	5
How can quantum computing be applied in clinical trial design and optimization?	5
Advisory Board and Contents	5
FOXO transcription factors as therapeutic targets in human diseases	5