Antiviral Research

Article	Citations
Editorial Board	358
Editorial Board	101
RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination	97
Editorial Board	64
Editorial Board	62
Progress in novel delivery technologies to improve efficacy of therapeutic antibodies	61
Corrigendum to “Crystal structure and cap binding analysis of the methyltransferase of langat virus” [Antivir. Res. 208 (2022) 105459]	61
A novel model based on qAnti-HBc and conventional biomarkers for identifying significant liver injury among CHB patients with ALT ≤ ULN	57
Novel inhibitors of HSV-1 protease effective in vitro and in vivo	55
Comparison of the effects of different potent adjuvants on enhancing the immunogenicity and cross-protection by influenza virus vaccination in young and aged mice	55
A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy	47
Long-term and efficient inhibition of hepatitis B virus replication by AAV8-delivered artificial microRNAs	44
Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study	41
Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier	37
Development of cell culture infectious clones for hepatitis C virus genotype 1b and transcription analysis of 1b-infected hepatoma cells	36
Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2	36
Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models	36
Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models.	35
Chemical-induced degradation of PreS2 mutant surface antigen via the induction of microautophagy	34
A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies	34
Novel strategy for Poxviridae prevention: Thermostable combined subunit vaccine patch with intense immune response	34
Berberine promotes K48-linked polyubiquitination of HNF4α, leading to the inhibition of HBV replication	34
Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals	34
Discovery and development of INNA-051, a TLR2/6 agonist for the prevention of complications resulting from viral respiratory infections	33
JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase	33

Corrigendum to “The novel therapeutic target and inhibitory effects of PF-429242 against Zika virus infection” [Antivir. Res. vol 192 (2021) 1–13/105121]	32
Methyl rosmarinate is an allosteric inhibitor of SARS-CoV-2 3 CL protease as a potential candidate against SARS-cov-2 infection	31
Editorial Board	31
Structural and quantitative comparison of viral infection-associated N-glycans in plasma from humans, pigs, and chickens: Greater similarity between humans and chickens than pigs	30
Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model	29
Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus	27
Structural biology of flavivirus NS1 protein and its antibody complexes	26
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection	26
Ergosterol peroxide inhibits HBV infection by inhibiting the binding of the pre-S1 domain of LHBsAg to NTCP	26
Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses	26
Clinical and experimental evidence for transplacental vertical transmission of flaviviruses	25
Implications of the antiviral drug favipiravir on rabies immunoglobulin for post-exposure prophylaxis of rabies in mice model with category III-like exposures	25
Ensitrelvir treatment–emergent amino acid substitutions in SARS-CoV-2 3CLpro detected in the SCORPIO-SR phase 3 trial	25
Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery	25
Inhibition of Chikungunya virus early replication by intracellular nanoantibodies targeting nsP2 Epitope Rich Region	24
N-arylpyrimidinamine (NAPA) compounds are broadly acting inhibitors of human cytomegalovirus infection and spread	24
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies	24
Bictegravir alters glucose tolerance in vivo and causes hepatic mitochondrial dysfunction	23
Potent inhibition of diverse Omicron sublineages by SARS-CoV-2 fusion-inhibitory lipopeptides	23
MβCD inhibits SFTSV entry by disrupting lipid raft structure of the host cells	22
High dose sofosbuvir and sofosbuvir-plus-ribavirin therapy inhibit Hepatitis E Virus (HEV) replication in a rabbit model for acute HEV infection	22
Identification of novel Ebola virus inhibitors using biologically contained virus	22
A mimetic peptide of ACE2 protects against SARS-CoV-2 infection and decreases pulmonary inflammation related to COVID-19	22
Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database (CHARMD)	21
Nirmatrelvir exerts distinct antiviral potency against different human coronaviruses	21
Therapeutic targeting of organelles for inhibition of Zika virus replication in neurons	21
Establishment of a robust rat hepatitis E virus fecal-oral infection model and validation for antiviral studies	21
Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2	21
Research Alliance for Veterinary Science and Biodefense BSL-3 Network (RAV3N): Report on network origin and phase I activities	21
Does a detectable HCV RNA at the end of DAA therapy herald treatment failure?	21
Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results	21
Chelerythrine chloride inhibits Zika virus infection by targeting the viral NS4B protein	20
Editorial Board	20
Next-generation sequencing for cytomegalovirus antiviral resistance genotyping in a clinical virology laboratory	20
Editorial Board	20
Targeting PI4KB and Src/Abl host kinases as broad-spectrum antiviral strategy: Myth or real opportunity?	19
Eeyarestatin I, an inhibitor of the valosin-containing protein, exhibits potent virucidal activity against the flaviviruses	19
Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection	19
Large-scale deep learning identifies the antiviral potential of PKI-179 and MTI-31 against coronaviruses	19
Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo	19
The diverse roles of peroxisomes in the interplay between viruses and mammalian cells	19
Nucleotide analogues and mpox: Repurposing the repurposable	19
Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism	19
Lung transcriptomics of K18-hACE2 mice highlights mechanisms and genes involved in the MVA-S vaccine-mediated immune response and protection against SARS-CoV-2 infection	18
Sulfated β-glucan from Agaricus subrufescens inhibits flavivirus infection and nonstructural protein 1-mediated pathogenesis	18
Intranasal exposure to commensal bacterium Rothia mucilaginosa protects against influenza A virus infection	18
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters	18
Host factor DUSP5 potently inhibits dengue virus infection by modulating cytoskeleton rearrangement	18
Broad-spectrum antiviral activity of two structurally analogous CYP3A inhibitors against pathogenic human coronaviruses in vitro	18
A spatiotemporally controlled recombinant cccDNA mouse model for studying HBV and developing drugs against the virus	18

Intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against SARS-CoV-2	18
Biological characterization of AB-343, a novel and potent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity	18
Antiviral effect of vesatolimod (GS-9620) against foot-and-mouth disease virus both in vitro and in vivo	18
Interim analysis of the PARADISE study: Benefits of add-on peginterferon-α in NA-treated patients with CHB	18
HIV protease inhibitor attenuated astrocyte autophagy involvement in inflammation via p38 MAPK pathway	18
Lipid-targeting antiviral strategies: Current state and future perspectives	18
Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway	17
Virus infection and sphingolipid metabolism	17
High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to baloxavir in vitro	17
Viral replicon particles protect IFNAR−/− mice against lethal Crimean-Congo hemorrhagic fever virus challenge three days after vaccination	17
Potential application of antiviral coumarin in aquaculture against IHNV infection by reducing viral adhesion to the epithelial cell surface	17
Performance of sofosbuvir and NITD008 in extrahepatic neuronal cells against HEV	17
LAVR-289, a Broad-Spectrum Antiviral, Protects Immunosuppressed Syrian Hamsters Against Lethal Adenovirus Challenge	17
Antigenic mapping of enterovirus A71 from Taiwan and Southeast Asia	16
Editorial Board	16
Induction of neutralizing antibodies and mucosal IgA through intranasal immunization with the receptor binding domain of SARS-CoV-2 spike protein fused with the type IIb E. coli heat-labile enterotoxi	16
Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals	16
Hemin protects against Zika virus infection by disrupting virus-endosome fusion	16
Editorial Board	16
Construction of a recombinant African swine fever virus with firefly luciferase and eGFP reporter genes and its application in high-throughput antiviral drug screening	15
New technologies in therapeutic antibody development: The next frontier for treating infectious diseases	15
Antiviral drug discovery with an optimized biochemical dengue protease assay: Improved predictive power for antiviral efficacy	15
Identification of alpha-linolenic acid as a broad-spectrum antiviral against zika, dengue, herpes simplex, influenza virus and SARS-CoV-2 infection	15
A recombinant Cedar virus based high-throughput screening assay for henipavirus antiviral discovery	15
Homoseongomycin, a compound isolated from marine actinomycete bacteria K3-1, is a potent inhibitor of encephalitic alphaviruses	15
Porcine interferon-α linked to the porcine IgG-Fc induces prolonged and broad-spectrum antiviral effects against foot-and-mouth disease virus	15
Targeting sgRNA N secondary structure as a way of inhibiting SARS-CoV-2 replication	15
Differential expression of HIV envelope epitopes on the surface of HIV-Infected macrophages and CD4+ T cells	15
Development of a rapid image-based high-content imaging screening assay to evaluate therapeutic antibodies against the monkeypox virus	15
Structural and mechanistic insight into the phosphorylation reaction catalyzed by mpox virus thymidine kinase	15
The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice	15
Development of a novel minigenome and recombinant VSV expressing Seoul hantavirus glycoprotein-based assays to identify anti-hantavirus therapeutics	15
Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group	15
Astersaponin I from Aster koraiensis is a natural viral fusion blocker that inhibits the infection of SARS-CoV-2 variants and syncytium formation	14
Editorial Board	14
Coronavirus nucleocapsid-based vaccine provides partial protection against hetero-species coronavirus in murine models	14
Design and synthesis of a new series of hybrids of functionalised N1-[(1H-1,2,3-triazol-4-yl)methyl]quinazoline-2,4-dione with antiviral activity against Respiratory Syncytial Virus	14
Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants	14
Editorial Board	14
Three in one: An effective and universal vaccine expressing heterologous tandem RBD trimer by rabies virus vector protects mice against SARS-CoV-2	14
RNA virus infections and their effect on host alternative splicing	14
Niclosamide inhibits hepatitis E virus through suppression of NF-kappaB signalling	14
Editorial Board	14
High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection	13
Editorial Board	13
Screening and identification of Lassa virus endonuclease-targeting inhibitors from a fragment-based drug discovery library	13
Current and future use of antibody-based passive immunity to prevent or control HBV/HDV infections	13
CDK4/6 inhibitor palbociclib promotes SARS-CoV-2 cell entry by down-regulating SKP2 dependent ACE2 degradation	13
Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication	13
Cold-adapted influenza vaccine carrying three repeats of a respiratory syncytial virus (RSV) fusion glycoprotein epitope site protects BALB/c mice and cotton rats against RSV infection	13
Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model	13
Optimization of Bangladesh and Malaysian genotype recombinant reporter Nipah viruses for in vitro antiviral screening and in vivo disease modeling	13
The host-targeted antiviral drug Zapnometinib exhibits a high barrier to the development of SARS-CoV-2 resistance	13
Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy	13
GS-1 blocks entry of herpes viruses and more broadly inhibits enveloped viruses	13
RNA-Binding motif protein 38 (RBM38) mediates HBV pgRNA packaging into the nucleocapsid	13
Antiviral strategies against human metapneumovirus: Targeting the fusion protein	13
Insights on the antiviral mechanisms of action of the TLR1/2 agonist Pam3CSK4 in hepatitis B virus (HBV)-infected hepatocytes	13
Identification of West Nile virus RNA-dependent RNA polymerase non-nucleoside inhibitors by real-time high throughput fluorescence screening	13
History and impact of the mouse-adapted Ebola virus model	13
Deubiquitinase USP39 promotes SARS-CoV-2 replication by deubiquitinating and stabilizing the envelope protein	13
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants	13
25R,26-hydroxycholesterol and an oxysterol synthetic analog inhibit Varicella zoster Virus replication	12
Evaluation of panel of neutralising murine monoclonal antibodies and a humanised bispecific antibody against influenza A(H1N1)pdm09 virus infection in a mouse model	12
Influenza antivirals and their role in pandemic preparedness	12
Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants	12
Editorial Board	12
Exploiting Host Kinases to Combat Dengue Virus Infection and Disease	12
Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus	12
Expanding the anti-flaviviral arsenal: Discovery of a baicalein-derived Compound with potent activity against DENV and ZIKV.	12
PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding	12
Baseline serum hepatitis B core antibody level predicts HBeAg seroconversion in patients with HBeAg-positive chronic hepatitis B after antiviral treatment	12
CD47 expression attenuates Ebola virus-induced immunopathology in mice	12
Nafamostat mesylate as a broad-spectrum candidate for the treatment of flavivirus infections by targeting envelope proteins	12
Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication	12
Editorial Board	12
Induction of antiviral gene expression by cyclosporine A, but not inhibition of cyclophilin A or B, contributes to its restriction of human coronavirus 229E infection in a lung epithelial cell line	12
Salicylamide derivative JMX0312 protects immunosuppressed Syrian hamsters against adenovirus lethal challenge	12
Novel quinolone derivatives targeting human dihydroorotate dehydrogenase suppress Ebola virus infection in vitro	11
Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus	11

Editorial Board	11
Licochalcone A inhibits enterovirus A71 replication in vitro and in vivo	11
Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus	11
β-d-N4-hydroxycytidine, a metabolite of molnupiravir, exhibits in vitro antiviral activity against rabies virus	11
Cathepsin inhibitors nitroxoline and its derivatives inhibit SARS-CoV-2 infection	11
Association of C-reactive protein polymorphisms with serum-CRP concentration and viral load among dengue-chikungunya mono/co-infected patients	11
Tissue replication and mucosal swab detection of Sosuga virus in Syrian hamsters in the absence of overt tissue pathology and clinical disease	11
Marburg and Kasokero viruses elicit differential antiviral innate immune control by their natural reservoir bat, the Egyptian rousette (Rousettus aegyptiacus)	11
Inhibitory effect of a novel thiazolidinedione derivative on hepatitis B virus entry	11
Recombinant pseudorabies virus (PRV) expressing stabilized E2 of classical swine fever virus (CSFV) protects against both PRV and CSFV	11
Activation of cGAS-STING suppresses coxsackievirus replication via interferon-dependent signaling	11
Dynamic features of virus protein 1 and substitutions in the 3-phenyl ring determine the potency and broad-spectrum activity of capsid-binding pyrazolo[3,4-d]pyrimidines against rhinoviruses	11
Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening	11
New insights into the neuraminidase-mediated hemagglutination activity of influenza A(H3N2) viruses	10
Characterization of clinical envelopes with lack of sensitivity to the HIV-1 inhibitors temsavir and ibalizumab	10
The calcium channel inhibitor lacidipine inhibits Zika virus replication in neural progenitor cells	10
Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome	10
Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis	10
Editorial Board	10
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A screen of FDA-approved drugs with minigenome identified tigecycline as an antiviral targeting nucleoprotein of Crimean-Congo hemorrhagic fever virus	10
Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains	10
Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate	10
RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5ʹ-untranslated region	10
Screening of an epigenetic compound library identifies BRD4 as a potential antiviral target for hepatitis B virus covalently closed circular DNA transcription	10
Editorial Board	10
Low antiviral resistance in Influenza A and B viruses isolated in Mexico from 2010 to 2023	10
A bivalent form of a RBD-specific synthetic antibody effectively neutralizes SARS-CoV-2 variants	10
Effect of E23G/K, F36V, N37T, E119D, and E199G polymerase acidic protein substitutions on the replication and baloxavir susceptibility of influenza B viruses	10
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication	10
Antisense oligonucleotides as drugs with both direct and indirect antiviral actions	10
Evaluation of pharmacokinetics of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil (TDF) in pregnant and postpartum women in South Africa: PrEP-PP PK study	10
Antiviral mechanisms and preclinical evaluation of amantadine analogs that continue to inhibit influenza A viruses with M2S31N-based drug resistance	10
Functional assessments of SARS-CoV-2 single-round infectious particles with variant-specific spike proteins on infectivity, drug sensitivity, and antibody neutralization	9
Viral sequence analysis of chronic hepatitis B patients treated with the capsid assembly modulator JNJ-56136379 in the JADE phase 2a study	9
β-D-N4-hydroxycytidine (NHC, EIDD-1931) inhibits chikungunya virus replication in mosquito cells and ex vivo Aedes aegypti guts, but not when ingested during blood-feeding	9
Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2	9
Antiviral drugs block replication of highly immune-evasive Omicron subvariants ex vivo, but fail to reduce tissue inflammation	9
Editorial Board	9
Anti-SARS-CoV-2 activity of cyanopeptolins produced by Nostoc edaphicum CCNP1411	9
KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells	9
α7 nicotinic receptor activation mitigates herpes simplex virus type 1 infection in microglia cells	9
Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro	9
Characterization of SARS-CoV-2 replication in human H1299/ACE2 cells: A versatile and practical infection model for antiviral research and beyond	9
Evaluation of a novel severe combined immunodeficiency mouse model for antiviral drug evaluation against Chandipura virus infection	9
Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues	9
Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA	9
Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families	9
Cyclic lipopeptides as membrane fusion inhibitors against SARS-CoV-2: New tricks for old dogs	9
Identification of Ascomycin against Zika virus infection through screening of natural product library	9
Pinostrobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism	9
5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro	9
Vemurafenib inhibits the replication of diabetogenic enteroviruses in intestinal epithelial and pancreatic beta cells	9
Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: Blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the vira	9
Zika virus replication is impaired by a selective agonist of the TRPML2 ion channel	9
Assessing the chronic hepatitis B adaptive immune response by profiling specific T-cell receptor repertoire	9
NK-lysin peptides ameliorate viral encephalopathy and retinopathy disease signs and provide partial protection against nodavirus infection in European sea bass	9
Identification of oxysterol synthetic analogs as a novel class of late-stage inhibitors of herpes simplex virus 2 replication	9
The ApoA1-mimetic peptide 4F blocks flavivirus NS1-triggered endothelial dysfunction and protects against lethal dengue virus challenge	9
Cinnamic acid inhibits Zika virus by inhibiting RdRp activity	9
Remdesivir inhibits the polymerases of the novel filoviruses Lloviu and Bombali virus	9