Antiviral Research

Article	Citations
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro	1413
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro	691
Coronavirus membrane fusion mechanism offers a potential target for antiviral development	615
Of chloroquine and COVID-19	418
Type 1 interferons as a potential treatment against COVID-19	395
Antiviral activities of type I interferons to SARS-CoV-2 infection	338
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern	301
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites	255
A potential role for integrins in host cell entry by SARS-CoV-2	254
The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer	240
Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions	233
Hepatitis B virus biology and life cycle	156
Lower prevalence of antibodies neutralizing SARS-CoV-2 in group O French blood donors	114
In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2	114
Identification of SARS-CoV RBD-targeting monoclonal antibodies with cross-reactive or neutralizing activity against SARS-CoV-2	103
Hepatitis B virus cccDNA: Formation, regulation and therapeutic potential	96
A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19	96
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters	91
Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses	86
A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase	69
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B	65
Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes	59
Put a cork in it: Plugging the M2 viral ion channel to sink influenza	54
Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway	51
A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents	48

An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral	46
Benefit-risk assessment for brincidofovir for the treatment of smallpox: U.S. Food and Drug Administration's Evaluation	46
Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2018–2020	45
Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E	45
Immunoglobulin fragment F(ab’)2 against RBD potently neutralizes SARS-CoV-2 in vitro	43
Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro	43
Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses	42
Characterization of the antiviral effects of REP 2139 on the HBV lifecycle in vitro	42
Mechanisms of HBV immune evasion	41
Very low levels of remdesivir resistance in SARS-COV-2 genomes after 18 months of massive usage during the COVID19 pandemic: A GISAID exploratory analysis	41
Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies	39
Concerns about pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PK-PD) studies in the new therapeutic area of COVID-19 infection	39
Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice	39
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection	37
HBV replication inhibitors	35
An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection	34
Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2	34
Antiviral activity of Apigenin against buffalopox: Novel mechanistic insights and drug-resistance considerations	34
Burden of influenza B virus infection and considerations for clinical management	34
Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir	33
Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development	33
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry	33
A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2	33
Current knowledge on Hepatitis Delta Virus replication	33
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo	32
Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system	32
Cinnamic acid inhibits Zika virus by inhibiting RdRp activity	31
Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry	30
Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection	29
Betulinic acid exhibits antiviral effects against dengue virus infection	28
Generation and characterization of Japanese encephalitis virus expressing GFP reporter gene for high throughput drug screening	28
HBV evolution and genetic variability: Impact on prevention, treatment and development of antivirals	28
A synthetic STING agonist inhibits the replication of human parainfluenza virus 3 and rhinovirus 16 through distinct mechanisms	27
Artemisinin inhibits the replication of flaviviruses by promoting the type I interferon production	27
In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs’ cleavage by CRISPR/Cas13a system	27
Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway	27
Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales	26
The chemokine receptor antagonist cenicriviroc inhibits the replication of SARS-CoV-2 in vitro	26
Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors	26
The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo	26
Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues	25
Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group	25
ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity	24
Effectiveness of pegylated interferon monotherapy in the treatment of chronic hepatitis D virus infection: A meta-analysis	23
Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation	23
Allosteric inhibitors of the main protease of SARS-CoV-2	23
Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding	22
Influenza A(H1N1)pdm09 virus exhibiting reduced susceptibility to baloxavir due to a PA E23K substitution detected from a child without baloxavir treatment	22
Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication	22
Efficacy of favipiravir (T-705) against Crimean-Congo hemorrhagic fever virus infection in cynomolgus macaques	22

Antiviral drugs targeting endosomal membrane proteins inhibit distant animal and human pathogenic viruses	22
Iminosugars: A host-targeted approach to combat Flaviviridae infections	22
Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro	22
Clinical outcome and the role of antivirals in congenital cytomegalovirus infection	22
Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model	21
Perspectives on stopping nucleos(t)ide analogues therapy in patients with chronic hepatitis B	21
Targeting host DEAD-box RNA helicase DDX3X for treating viral infections	21
Influenza antivirals and their role in pandemic preparedness	21
Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors	21
Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway	21
Amide-containing α-hydroxytropolones as inhibitors of hepatitis B virus replication	21
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening	21
Hepatoprotective, antioxidant, anti-inflammatory, and antiviral activities of silymarin against mayaro virus infection	20
Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augm	20
Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target	20
Antiviral activities of four marine sulfated glycans against adenovirus and human cytomegalovirus	20
Reasons to consider early treatment in chronic hepatitis B patients	20
E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation	19
Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking	19
COVID-19, Influenza and RSV: Surveillance-informed prevention and treatment – Meeting report from an isirv-WHO virtual conference	19
14-Deoxy-11,12-didehydroandrographolide inhibits apoptosis in influenza A(H5N1) virus-infected human lung epithelial cells via the caspase-9-dependent intrinsic apoptotic pathway which contributes to	18
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies	18
Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase	18
S-adenosylmethionine-dependent methyltransferase inhibitor DZNep blocks transcription and translation of SARS-CoV-2 genome with a low tendency to select for drug-resistant viral variants	18
A novel method to precisely quantify hepatitis B virus covalently closed circular (ccc)DNA formation and maintenance	18
New methylene blue derivatives suggest novel anti-orthopoxviral strategies	18
Repurposing Pyramax®, quinacrine and tilorone as treatments for Ebola virus disease	18
5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis	17
Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir	17
Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro	17
Immunobiology of Crimean-Congo hemorrhagic fever	17
Failure to bictegravir and development of resistance mutations in an antiretroviral-experienced patient	17
Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2	16
Characterization of contemporary influenza B recombinant viruses harboring mutations of reduced susceptibility to baloxavir marboxil, in vitro and in mice	16
A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse sera	16
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening	16
Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein	15
NK-lysin peptides ameliorate viral encephalopathy and retinopathy disease signs and provide partial protection against nodavirus infection in European sea bass	15
Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts	15
Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro	15
Sofosbuvir shows a protective effect against vertical transmission of Zika virus and the associated congenital syndrome in rhesus monkeys	15
Next-generation sequencing for cytomegalovirus antiviral resistance genotyping in a clinical virology laboratory	15
A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge	15
The novel therapeutic target and inhibitory effects of PF-429242 against Zika virus infection	15
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis	15
Glibenclamide inhibits BK polyomavirus infection in kidney cells through CFTR blockade	15
A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of type I interferon	15
A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection	14
Reverse genetic systems of SARS-CoV-2 for antiviral research	14
Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses	14
The influence of interferon-lambda on restricting Middle East Respiratory Syndrome Coronavirus replication in the respiratory epithelium	14
Vaccine strain of O/ME-SA/Ind-2001e of foot-and-mouth disease virus provides high immunogenicity and broad antigenic coverage	14
Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90	14
Suppression effect of plant-derived berberine on cyprinid herpesvirus 2 proliferation and its pharmacokinetics in Crucian carp (Carassius auratus gibelio)	14
Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs	14
Conserved coronavirus proteins as targets of broad-spectrum antivirals	14
Substitution-inert polynuclear platinum compounds inhibit human cytomegalovirus attachment and entry	14
Generation of a reporter yellow fever virus for high throughput antiviral assays	14
Anti-flavivirus activity of polyoxometalate	14
Clinical and virological responses to a broad-spectrum human monoclonal antibody in an influenza virus challenge study	14
Detection of baloxavir resistant influenza A viruses using next generation sequencing and pyrosequencing methods	14
Phenothiazines inhibit SARS-CoV-2 cell entry via a blockade of spike protein binding to neuropilin-1	14
ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concern	14
Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors	14
Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses	14
Target verification of artesunate-related antiviral drugs: Assessing the role of mitochondrial and regulatory proteins by click chemistry and fluorescence labeling	13
Enzymatically synthesized 2′-fluoro-modified Dicer-substrate siRNA swarms against herpes simplex virus demonstrate enhanced antiviral efficacy and low cytotoxicity	13
Identification of entry inhibitors with 4-aminopiperidine scaffold targeting group 1 influenza A virus	13
Functional neuraminidase inhibitor resistance motifs in avian influenza A(H5Nx) viruses	13
In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2	13
Duration of fever and symptoms in children after treatment with baloxavir marboxil and oseltamivir during the 2018–2019 season and detection of variant influenza a viruses with polymerase acidic subun	13
Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3	13
Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients	13
Animal models for the study of human hepatitis B and D virus infection: New insights and progress	13
Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig	13
Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2	13
Current status of silica-based nanoparticles as therapeutics and its potential as therapies against viruses	13
A dengue type 2 reporter virus assay amenable to high-throughput screening	13
Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier	13
Evaluation of antiviral drugs against newly emerged SARS-CoV-2 Omicron subvariants	13

DDX3 inhibitors show antiviral activity against positive-sense single-stranded RNA viruses but not against negative-sense single-stranded RNA viruses: The coxsackie B model	12
Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors	12
The trimeric artesunate derivative TF27 exerts strong anti-cytomegaloviral efficacy: Focus on prophylactic efficacy and oral treatment of immunocompetent mice	12
Hepatitis D virus: Improving virological knowledge to develop new treatments	12
Potential application of antiviral coumarin in aquaculture against IHNV infection by reducing viral adhesion to the epithelial cell surface	12
Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines	12
A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency	12
Immunodetection assays for the quantification of seasonal common cold coronaviruses OC43, NL63, or 229E infection confirm nirmatrelvir as broad coronavirus inhibitor	12
Nirmatrelvir exerts distinct antiviral potency against different human coronaviruses	12
Comparative pathology study of Venezuelan, eastern, and western equine encephalitis viruses in non-human primates	12
Infectious bronchitis virus: Identification of Gallus gallus APN high-affinity ligands with antiviral effects	11
Ergosterol peroxide inhibits HBV infection by inhibiting the binding of the pre-S1 domain of LHBsAg to NTCP	11
In vitro and in vivo efficacy of a novel nucleoside analog H44 against Crimean–Congo hemorrhagic fever virus	11
Loss of hepatitis D virus infectivity upon farnesyl transferase inhibitor treatment associates with increasing RNA editing rates revealed by a new RT-ddPCR method	11
LINCS dataset-based repositioning of rosiglitazone as a potential anti-human adenovirus drug	11
Small molecule inhibitors possibly targeting the rearrangement of Zika virus envelope protein	11
Discovery of novel SARS-CoV-2 inhibitors targeting the main protease Mpro by virtual screenings and hit optimization	11
Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease	11
Identification of a novel inhibitor targeting influenza A virus group 2 hemagglutinins	11
The NF-κB inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses	11
SOX9 represses hepatitis B virus replication through binding to HBV EnhII/Cp and inhibiting the promoter activity	11
Multivalent DNA vaccine protects against genital herpes by T-cell immune induction in vaginal mucosa	11
A novel cell culture model reveals the viral interference during hepatitis B and C virus coinfection	10
Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species	10
Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing	10
Viral replicon particles protect IFNAR-/- mice against lethal Crimean-Congo hemorrhagic fever virus challenge three days after vaccination	10
Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing ant	10
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein	10
BX795 demonstrates potent antiviral benefits against herpes simplex Virus-1 infection of human cell lines	10
Identification of hepatitis B virus core protein residues critical for capsid assembly, pgRNA encapsidation and resistance to capsid assembly modulators	10
GS-441524 inhibits African swine fever virus infection in vitro	10
BIKE regulates dengue virus infection and is a cellular target for broad-spectrum antivirals	10
Licochalcone A inhibits enterovirus A71 replication in vitro and in vivo	10
Artificial intelligence: Machine learning approach for screening large database and drug discovery	10
A novel recombinant cccDNA-based mouse model with long term maintenance of rcccDNA and antigenemia	10
Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model	10
The human α-defensin-derived peptide HD5(1–9) inhibits cellular attachment and entry of human cytomegalovirus	10
The involvement of annexin A1 in human placental response to maternal Zika virus infection	10
Synergistic in-vitro antiviral effects of combination treatment using anidulafungin and T-1105 against Zika virus infection	10