Cancer and Metastasis Reviews

Article	Citations
Gastric cancer: a comprehensive review of current and future treatment strategies	312
The role of fibroblast activation protein in health and malignancy	189
Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?	162
Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?	156
Molecular epidemiology and diagnostics of KRAS mutations in human cancer	154
FOXO transcription factor family in cancer and metastasis	146
CDK7 inhibitors as anticancer drugs	104
Lung cancer identification: a review on detection and classification	100
Molecular and cellular mechanisms underlying brain metastasis of breast cancer	80
Regulation of breast cancer metastasis signaling by miRNAs	76
Inhibitors of immune checkpoints—PD-1, PD-L1, CTLA-4—new opportunities for cancer patients and a new challenge for internists and general practitioners	75
Glioma: molecular signature and crossroads with tumor microenvironment	70
Current therapy of KRAS-mutant lung cancer	63
Checkpoint inhibitor therapy for metastatic triple-negative breast cancer	61
Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer	59
Wnts and the hallmarks of cancer	58
Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis	52
The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment	51
Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis	49
The adipocyte microenvironment and cancer	48
Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer	47
Neuroblastoma and the epigenome	46
Lipid metabolism reprogramming in renal cell carcinoma	43
The obesity-breast cancer link: a multidisciplinary perspective	42
Targeting KRAS in pancreatic cancer: new drugs on the horizon	42

Interaction between adipose tissue and cancer cells: role for cancer progression	41
The comprehensive landscape of miR-34a in cancer research	37
Gastrointestinal stromal tumor: a review of current and emerging therapies	36
Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy	35
Targeting the cytoskeleton against metastatic dissemination	35
The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance	34
Neutrophil-derived granule cargoes: paving the way for tumor growth and progression	33
An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression	33
The effects of mutant Ras proteins on the cell signalome	31
The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions	31
Long non-coding RNA: A recently accentuated molecule in chemoresistance in cancer	30
Tyrosine phosphorylation of tumor cell caveolin-1: impact on cancer progression	30
Molecular mediators of peritoneal metastasis in pancreatic cancer	30
Rethinking the biology of metastatic melanoma: a holistic approach	30
Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis	29
Glycosylation and raft endocytosis in cancer	29
Role of non-coding RNAs in tumor progression and metastasis in pancreatic cancer	29
Anti-HER2 therapy in metastatic breast cancer: many choices and future directions	28
The role of microbiome in pancreatic cancer	28
Inflammatory bowel disease and carcinogenesis	27
Cyclin-dependent kinase inhibitors in head and neck cancer and glioblastoma—backbone or add-on in immune-oncology?	26
K-Ras prenylation as a potential anticancer target	26
MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein	26
The role of caspase-8 in the tumor microenvironment of ovarian cancer	25
Unraveling mucin domains in cancer and metastasis: when protectors become predators	25
Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity	25
Epigenetic dynamics in cancer stem cell dormancy	24
Centrosome amplification: a quantifiable cancer cell trait with prognostic value in solid malignancies	24
The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options	23
Platelets as messengers of early-stage cancer	23
Role of linoleic acid-derived oxylipins in cancer	22
The role of the metabolite cargo of extracellular vesicles in tumor progression	22
Obesity: a perfect storm for carcinogenesis	22
Role of myeloid-derived suppressor cells in metastasis	21
Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution	21
Metformin: review of epidemiology and mechanisms of action in pancreatic cancer	21
Multiple roles of HOX proteins in Metastasis: Let me count the ways	20
Platelets in aging and cancer—“double-edged sword”	20
Visualizing cancer extravasation: from mechanistic studies to drug development	19
Current therapy of advanced colorectal cancer according to RAS/RAF mutational status	19
Current methods in translational cancer research	19
Exosomes: a new perspective in EGFR-mutated lung cancer	19
Membrane tension buffering by caveolae: a role in cancer?	19
Treatment against glucose-dependent cancers through metabolic PFKFB3 targeting of glycolytic flux	19
Extracellular citrate and metabolic adaptations of cancer cells	18
Epigenetic modulation of immunotherapy and implications in head and neck cancer	18
Targeting DNA damage repair pathways in pancreas cancer	18
Mechanistic insights into the interplays between neutrophils and other immune cells in cancer development and progression	18
Safety of radiosurgery concurrent with systemic therapy (chemotherapy, targeted therapy, and/or immunotherapy) in brain metastases: a systematic review	18
Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance	17

A bi-directional dialog between vascular cells and monocytes/macrophages regulates tumor progression	17
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis	17
Informing the new developments and future of cancer immunotherapy	17
Adipocytokines and disease progression in endometrial cancer: a systematic review	17
Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation	17
Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery	16
Small molecule inhibitors of RAS proteins with oncogenic mutations	16
The multifaceted roles of the chemokines CCL2 and CXCL12 in osteophilic metastatic cancers	16
Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations	15
A multidisciplinary perspective on the complex interactions between sleep, circadian, and metabolic disruption in cancer patients	15
Mucins reprogram stemness, metabolism and promote chemoresistance during cancer progression	15
What do cellular responses to acidity tell us about cancer?	15
Debris-stimulated tumor growth: a Pandora’s box?	15
The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer	15
Nanoparticle-mediated cancer cell therapy: basic science to clinical applications	15
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?	14
Endothelial caveolin and its scaffolding domain in cancer	14
Breast cancer microenvironment and obesity: challenges for therapy	14
Structure-based inhibitor design of mutant RAS proteins—a paradigm shift	14
MicroRNAs as a clue to overcome breast cancer treatment resistance	13
MHC heterogeneity and response of metastases to immunotherapy	13
The role of tumor heterogeneity in immune-tumor interactions	13
Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers	13
Glycosylation as a regulator of site-specific metastasis	13
A perspective on the early days of RAS research	13
Potential mechanisms of tumor progression associated with postoperative infectious complications	13
Mesenchymal stromal cell senescence in haematological malignancies	12
The role of metabolic ecosystem in cancer progression — metabolic plasticity and mTOR hyperactivity in tumor tissues	12
Oncobiology and treatment of breast cancer in young women	12
Beyond tradition and convention: benefits of non-traditional model organisms in cancer research	12
RNA-biology ruling cancer progression? Focus on 3′UTRs and splicing	12
Dormant cancer cells: programmed quiescence, senescence, or both?	11
Macrophages in multiple myeloma: key roles and therapeutic strategies	11
Connecting the Human Microbiome and Pancreatic Cancer	11
The timing of adiposity and changes in the life course on the risk of cancer	11
Rho GTPases in cancer radiotherapy and metastasis	11
Emerging roles of epithelial-mesenchymal plasticity in invasion-metastasis cascade and therapy resistance	11
Oral delivery of RNAi for cancer therapy	11
Insights into the role of senescence in tumor dormancy: mechanisms and applications	11
Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets	11
Splice variants of RAS—translational significance	11
The multifaceted mechanisms of malignant glioblastoma progression and clinical implications	11
Natural compounds targeting nuclear receptors for effective cancer therapy	11
Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression	10
Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors	10
Systematic review of the receptor tyrosine kinase superfamily in neuroblastoma pathophysiology	10
Regulation of dormancy during tumor dissemination: the role of the ECM	10
A systems biology approach to discovering pathway signaling dysregulation in metastasis	10
Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression	10
The role of obesity and bariatric surgery-induced weight loss in breast cancer	10
Obesity, cancer risk, and time-restricted eating	9
The cure from within? a review of the microbiome and diet in melanoma	9
Models of pancreatic ductal adenocarcinoma	9
Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?	9
Decoding human cancer with whole genome sequencing: a review of PCAWG Project studies published in February 2020	9
Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases	9
Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry	9
Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities	9
Implications of prognosis-associated genes in pancreatic tumor metastasis: lessons from global studies in bioinformatics	9
The gut microbiome, immune check point inhibition and immune-related adverse events in non-small cell lung cancer	9
Brain tumor vessels—a barrier for drug delivery	8
Targeting lipid metabolism in cancer: neuroblastoma	8
Understanding metabolic alterations and heterogeneity in cancer progression through validated immunodetection of key molecular components: a case of carbonic anhydrase IX	8
Heterogeneity and tumor evolution reflected in liquid biopsy in metastatic breast cancer patients: a review	8
Multiprong control of glioblastoma multiforme invasiveness: blockade of pro-inflammatory signaling, anti-angiogenesis, and homeostasis restoration	8
Role of myeloid-derived suppressor cells in tumor recurrence	8
Emerging roles for myeloid immune cells in bone metastasis	8
Nanotechnology-aided advancement in the combating of cancer metastasis	8
Model systems in SDHx-related pheochromocytoma/paraganglioma	8
Oncogenic signaling-mediated regulation of chromatin during tumorigenesis	8
Pancreatic cancer pathology viewed in the light of evolution	7
Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets	7
Immunotherapy for triple negative breast cancer: the end of the beginning or the beginning of the end?	7
Notch signaling in malignant gliomas: supporting tumor growth and the vascular environment	7
Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic?	7
Targeting miRNA and using miRNA as potential therapeutic options to bypass resistance in pancreatic ductal adenocarcinoma	7
Autophagy, molecular chaperones, and unfolded protein response as promoters of tumor recurrence	7
The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer	7
Impact of posttranslational modifications in pancreatic carcinogenesis and treatments	7
Involvement of redox signalling in tumour cell dormancy and metastasis	7

The emerging roles of circular RNAs in vessel co-option and vasculogenic mimicry: clinical insights for anti-angiogenic therapy in cancers	7
Cohesive cancer invasion of the biophysical barrier of smooth muscle	7
Of vascular defense, hemostasis, cancer, and platelet biology: an evolutionary perspective	7