Journal of Controlled Release

Article	Citations
Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions	451
Electrospinning for drug delivery applications: A review	363
Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment	344
Photothermal therapy	315
Polymeric micelles in cancer therapy: State of the art	285
The dawn of mRNA vaccines: The COVID-19 case	277
Chitosan hydrogels for sustained drug delivery	251
Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies	244
Delivering the power of nanomedicine to patients today	222
Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance	216
Nanoparticles in sustainable agriculture: An emerging opportunity	204
Vat photopolymerization 3D printing for advanced drug delivery and medical device applications	196
Advances and limitations of drug delivery systems formulated as eye drops	182
Bacterial outer membrane vesicles as a platform for biomedical applications: An update	171
Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake	169
Controlled release fertilizer: A review on developments, applications and potential in agriculture	168
Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges	166
Chronic wounds: Current status, available strategies and emerging therapeutic solutions	157
Challenges in the development and establishment of exosome-based drug delivery systems	157
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity	156
In vivo gene delivery mediated by non-viral vectors for cancer therapy	155
The role of natural polymers in bone tissue engineering	154
A review of nanotechnology-based approaches for breast cancer and triple-negative breast cancer	152
Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing	152
Charge-reversal biodegradable MSNs for tumor synergetic chemo/photothermal and visualized therapy	150

Evolution of drug delivery systems: From 1950 to 2020 and beyond	145
Stimuli-responsive In situ gelling system for nose-to-brain drug delivery	141
Recent advances in polymeric transdermal drug delivery systems	139
Macrophage-mimic shape changeable nanomedicine retained in tumor for multimodal therapy of breast cancer	138
Advances in biodegradable and injectable hydrogels for biomedical applications	138
Advanced drug delivery applications of layered double hydroxide	136
Agarose-based biomaterials for advanced drug delivery	136
Zero-order drug delivery: State of the art and future prospects	136
Photo-responsive supramolecular hyaluronic acid hydrogels for accelerated wound healing	133
Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting	133
Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders	132
Ultrasound and microbubble mediated therapeutic delivery: Underlying mechanisms and future outlook	132
Microneedles for painless transdermal immunotherapeutic applications	131
Cell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy	129
Functionalized silk fibroin nanofibers as drug carriers: Advantages and challenges	128
Recent trends in organic coating based on biopolymers and biomass for controlled and slow release fertilizers	127
Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy	127
Aerogels in drug delivery: From design to application	127
Hyaluronic acid and albumin based nanoparticles for drug delivery	126
A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing	125
Nanoparticle–hydrogel superstructures for biomedical applications	123
Nanomedicines accessible in the market for clinical interventions	122
Metal-doped and hybrid carbon dots: A comprehensive review on their synthesis and biomedical applications	122
Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy	120
Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation	115
Non-viral vectors for RNA delivery	115
Preparation and application of pH-responsive drug delivery systems	113
Rational design of a minimalist nanoplatform to maximize immunotherapeutic efficacy: Four birds with one stone	112
Recent advances in nanotechnology-based drug delivery systems for the kidney	111
Stimuli-responsive nano-assemblies for remotely controlled drug delivery	111
Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems	111
Solid lipid nanoparticles for hydrophilic drugs	107
Hypromellose – A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery	104
Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery	103
Bioresponsive drug delivery systems for the treatment of inflammatory diseases	102
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy	99
M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization	99
Dissolving microneedles: Applications and growing therapeutic potential	98
Overcoming skin barriers through advanced transdermal drug delivery approaches	98
Thiolated polymeric hydrogels for biomedical application: Cross-linking mechanisms	98
Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics	97
Customizing nano-chitosan for sustainable drug delivery	97
Serum protein-based nanoparticles for cancer diagnosis and treatment	97
Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection	97
Progress in the design and development of “fast-dissolving” electrospun nanofibers based drug delivery systems - A systematic review	95
Hydrogel-forming microneedle arrays as a therapeutic option for transdermal esketamine delivery	95
Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines	94
Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic	94
Magnetic nanoparticles for cancer theranostics: Advances and prospects	94
Carrier-free nanodrugs for safe and effective cancer treatment	93

Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis	93
Machine learning predicts 3D printing performance of over 900 drug delivery systems	92
Recent advances in nanoparticle-based photothermal therapy for breast cancer	92
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines	91
Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer	90
Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges	89
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products	89
Bacteria and bacterial derivatives as drug carriers for cancer therapy	88
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs	88
Heterojunction engineered bioactive chlorella for cascade promoted cancer therapy	87
Synthesis and functionalization of hyperbranched polymers for targeted drug delivery	86
Recent advances and remaining barriers to producing novel formulations of fungicides for safe and sustainable agriculture	85
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation	85
In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review	84
Recent advances of redox-responsive nanoplatforms for tumor theranostics	83
Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy	83
Ultrasound-responsive polymersomes capable of endosomal escape for efficient cancer therapy	83
Current trends in smart mesoporous silica-based nanovehicles for photoactivated cancer therapy	82
Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: A review	81
Inflammation-targeting polymeric nanoparticles deliver sparfloxacin and tacrolimus for combating acute lung sepsis	80
Recent advances in colon drug delivery systems	80
Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery	79
Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy	79
Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy	79
Graphene nanoribbons: A promising nanomaterial for biomedical applications	78
Current developments in nanotechnology for improved cancer treatment, focusing on tumor hypoxia	78
PCL-PEG copolymer based injectable thermosensitive hydrogels	77
Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury	77
Recent trends, challenges and future outlook of transdermal drug delivery systems for rheumatoid arthritis therapy	77
Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules	77
pH-Responsive charge switchable PEGylated ε-poly-l-lysine polymeric nanoparticles-assisted combination therapy for improving breast cancer treatment	76
Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy	76
Magnetic-responsive hydrogels: From strategic design to biomedical applications	76
ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease	76
Computational pharmaceutics - A new paradigm of drug delivery	76
Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment	76
Ionic liquid-mediated delivery of insulin to buccal mucosa	76
Intravitreal hydrogels for sustained release of therapeutic proteins	76
Dimeric prodrug-based nanomedicines for cancer therapy	75
Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury	75
Co-delivery of silybin and paclitaxel by dextran-based nanoparticles for effective anti-tumor treatment through chemotherapy sensitization and microenvironment modulation	75
Engineered extracellular vesicles and their mimetics for cancer immunotherapy	75
Therapeutic nanoemulsions in ophthalmic drug administration: Concept in formulations and characterization techniques for ocular drug delivery	74
Tendon tissue engineering: Cells, growth factors, scaffolds and production techniques	73
Platelet-armored nanoplatform to harmonize janus-faced IFN-γ against tumor recurrence and metastasis	73
Recent progress in design and preparation of glucose-responsive insulin delivery systems	72
Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications	72
Targeting cancer-associated fibroblasts by dual-responsive lipid-albumin nanoparticles to enhance drug perfusion for pancreatic tumor therapy	71
Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions	71
Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect	71
Acetal containing polymers as pH-responsive nano-drug delivery systems	71
Multifunctional graphene oxide nanoparticles for drug delivery in cancer	71
Cell membrane cloaked nanomedicines for bio-imaging and immunotherapy of cancer: Improved pharmacokinetics, cell internalization and anticancer efficacy	70
Tumor microenvironment-activated self-recognizing nanodrug through directly tailored assembly of small-molecules for targeted synergistic chemotherapy	70
Tumor cell membrane enveloped aluminum phosphate nanoparticles for enhanced cancer vaccination	70
Cyclodextrin based natural nanostructured carbohydrate polymers as effective non-viral siRNA delivery systems for cancer gene therapy	70
Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment	69
Stealth nanoparticles in oncology: Facing the PEG dilemma	69
Construction of microneedle-assisted co-delivery platform and its combining photodynamic/immunotherapy	68
Doxorubicin-loaded composite nanogels for cancer treatment	68
Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement	68
Nucleic acid-based drug delivery strategies	68
Exosome-based photoacoustic imaging guided photodynamic and immunotherapy for the treatment of pancreatic cancer	68
Conducting polymer hydrogels for electrically responsive drug delivery	67
Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives	67
Engineered exosome as targeted lncRNA MEG3 delivery vehicles for osteosarcoma therapy	67
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer	67
Extracellular vesicles for tumor targeting delivery based on five features principle	67
High resolution photopolymer for 3D printing of personalised microneedle for transdermal delivery of anti-wrinkle small peptide	67
Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020	66
CaCO3 crystals as versatile carriers for controlled delivery of antimicrobials	66
RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy	66
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment	66
On-demand fully customizable drug tablets via 3D printing technology for personalized medicine	65
Antibody and antibody fragments for cancer immunotherapy	65
Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches	65
Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic	65
Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles	65
Preservation of biomaterials and cells by freeze-drying: Change of paradigm	65
Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications	64

Bile acid transporter-mediated oral drug delivery	64
Dual delivery of stem cells and insulin-like growth factor-1 in coacervate-embedded composite hydrogels for enhanced cartilage regeneration in osteochondral defects	64
Development of nanoparticle-delivery systems for antiviral agents: A review	64
One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility	64
Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy	64
Ultrasound-responsive neurotrophic factor-loaded microbubble- liposome complex: Preclinical investigation for Parkinson's disease treatment	63
Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer	63
The reversal of chemotherapy-induced multidrug resistance by nanomedicine for cancer therapy	63
Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells	63
Recent advances and prospects of hyaluronan as a multifunctional therapeutic system	62
Albumin-biomineralized nanoparticles to synergize phototherapy and immunotherapy against melanoma	62
Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at permeability assessment methods and pharmacokinetic properties changes	62
Bacterial anti-microbial peptides and nano-sized drug delivery systems: The state of the art toward improved bacteriocins	62
Oral delivery of micro/nanoparticulate systems based on natural polysaccharides for intestinal diseases therapy: Challenges, advances and future perspectives	62
Melanin-loaded CpG DNA hydrogel for modulation of tumor immune microenvironment	62
Nanoceria, the versatile nanoparticles: Promising biomedical applications	62
Nanoscale drug delivery systems for controllable drug behaviors by multi-stage barrier penetration	62
Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases	61
Hyperbranched poly(β-amino ester) based polyplex nanopaticles for delivery of CRISPR/Cas9 system and treatment of HPV infection associated cervical cancer	61
Accelerating the development of novel technologies and tools for the subcutaneous delivery of biotherapeutics	61
Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment	61
Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression	61
Protein encapsulation by electrospinning and electrospraying	61
Self-assembled polymeric vesicles: Focus on polymersomes in cancer treatment	60
Pharmaceutical strategies for endoplasmic reticulum-targeting and their prospects of application	60
Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes	60
Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo	60
Advances in drug delivery technology for the treatment of glioblastoma multiforme	60
Lymphatic targeting by albumin-hitchhiking: Applications and optimisation	60
Controlled release of odontogenic exosomes from a biodegradable vehicle mediates dentinogenesis as a novel biomimetic pulp capping therapy	59
Nanoparticle delivery improves the pharmacokinetic properties of cyclic dinucleotide STING agonists to open a therapeutic window for intravenous administration	59
Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain	59
Formulation composition, manufacturing process, and characterization of poly(lactide-co-glycolide) microparticles	59
Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles	59
Target delivering paclitaxel by ferritin heavy chain nanocages for glioma treatment	58
Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks	58
Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy	58
Blockade of CTLA-4 increases anti-tumor response inducing potential of dendritic cell vaccine	58
Topical delivery of siRNA into skin using ionic liquids	57
Cell surface GRP78: An emerging imaging marker and therapeutic target for cancer	57
Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinson's disease	57
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)	57
Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines	57
Selenium and dopamine-crosslinked hyaluronic acid hydrogel for chemophotothermal cancer therapy	57
A tunable and injectable local drug delivery system for personalized periodontal application	57
DP7-C-modified liposomes enhance immune responses and the antitumor effect of a neoantigen-based mRNA vaccine	57
Metabolic reprogramming mediated PD-L1 depression and hypoxia reversion to reactivate tumor therapy	57
Tropism-facilitated delivery of CRISPR/Cas9 system with chimeric antigen receptor-extracellular vesicles against B-cell malignancies	56
Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections	56
Evasion of the accelerated blood clearance phenomenon by polysarcosine coating of liposomes	56
Immune cells as tumor drug delivery vehicles	56
Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems	56
Nanozyme-mediated cascade reaction based on metal-organic framework for synergetic chemo-photodynamic tumor therapy	56
Controlled drug delivery with nanoassemblies of redox-responsive prodrug and polyprodrug amphiphiles	56
Paper-based microfluidics for rapid diagnostics and drug delivery	56
Exosome membrane-modified M2 macrophages targeted nanomedicine: Treatment for allergic asthma	56
A pH-responsive silica–metal–organic framework hybrid nanoparticle for the delivery of hydrophilic drugs, nucleic acids, and CRISPR-Cas9 genome-editing machineries	56
Self-assembly of oxidation-responsive polyethylene glycol-paclitaxel prodrug for cancer chemotherapy	56
Oral delivery of bacteria: Basic principles and biomedical applications	55
Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery	55
Oral delivery of sorafenib through spontaneous formation of ionic liquid nanocomplexes	55
Ferrocene-containing polymersome nanoreactors for synergistically amplified tumor-specific chemodynamic therapy	55
Ultrasound in tumor immunotherapy: Current status and future developments	55
Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system	55
Tumor microenvironment-induced structure changing drug/gene delivery system for overcoming delivery-associated challenges	55
A superstable homogeneous lipiodol-ICG formulation for locoregional hepatocellular carcinoma treatment	55
Lipid nanoparticles loaded with ribonucleoprotein–oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition	55
Recent progresses in exosome-based systems for targeted drug delivery to the brain	55
A metal-organic framework-based immunomodulatory nanoplatform for anti-atherosclerosis treatment	55
Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo	55
pH-sensitive multi-drug liposomes targeting folate receptor β for efficient treatment of non-small cell lung cancer	54
Gold nanoparticle-mediated bubbles in cancer nanotechnology	54
Delivery of thymoquinone through hyaluronic acid-decorated mixed Pluronic® nanoparticles to attenuate angiogenesis and metastasis of triple-negative breast cancer	54
Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes	53
Bactericidal coating to prevent early and delayed implant-related infections	53
Biotherapeutic-loaded injectable hydrogels as a synergistic strategy to support myocardial repair after myocardial infarction	53
Magnetic particle targeting for diagnosis and therapy of lung cancers	53
Redox-responsive polyethyleneimine/tetrahedron DNA/doxorubicin nanocomplexes for deep cell/tissue penetration to overcome multidrug resistance	53
Opening of endothelial cell–cell contacts due to sonoporation	53
mRNA vaccines for COVID-19 and diverse diseases	52
A novel kinetic model to describe the ultra-fast triggered release of thermosensitive liposomal drug delivery systems	52
Emerging insights on drug delivery by fatty acid mediated synthesis of lipophilic prodrugs as novel nanomedicines	52
Self-assembly of amphiphilic phospholipid peptide dendrimer-based nanovectors for effective delivery of siRNA therapeutics in prostate cancer therapy	52
Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface	52
The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering	51
Triple negative breast cancer and non-small cell lung cancer: Clinical challenges and nano-formulation approaches	51
Iron nanoparticles augmented chemodynamic effect by alternative magnetic field for wound disinfection and healing	51
Self-assembling peptide hydrogels for the stabilization and sustained release of active Chondroitinase ABC in vitro and in spinal cord injuries	51
Ocular drug delivery to the anterior segment using nanocarriers: A mucoadhesive/mucopenetrative perspective	51
Anticancer DOX delivery system based on CNTs: Functionalization, targeting and novel technologies	51
Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation	51
Targeted nanomedicine in cisplatin-based cancer therapeutics	51
Temozolomide nano enabled medicine: promises made by the nanocarriers in glioblastoma therapy	51
Mucoadhesive nanoparticles based on ROS activated gambogic acid prodrug for safe and efficient intravesical instillation chemotherapy of bladder cancer	50
Controlled drug delivery systems in eradicating bacterial biofilm-associated infections	50