Journal of Controlled Release

Papers
(The median citation count of Journal of Controlled Release is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)
ArticleCitations
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes542
Prediction of drug capturing by lipid emulsions in vivo for the treatment of a drug overdose390
Outside Back Cover326
In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer284
Inside Back Cover284
Full-cycle study on developing a novel structured micromixer and evaluating the nanoparticle products as mRNA delivery carriers266
Pickering emulsion-guided monomeric delivery of monophosphoryl lipid A for enhanced vaccination264
Inside Back Cover251
Corrigendum to “Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch” [Journal of Controlled Release 372 (2024) 304–317]250
Outside Back Cover246
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3244
Outside Front Cover: Yisheng Peng et al230
The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair224
Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy211
Enhanced browning of adipose tissue by mirabegron-microspheres206
Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction193
Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling186
Adaptable peptide-based therapeutics modulating tumor microenvironment for combinatorial radio-immunotherapy182
A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine180
Oxygen-boosted fluorinated prodrug hybrid nanoassemblies for bidirectional amplification of breast cancer ferroptosis173
In vivo delivery of antioxidant enzymes with multi-functionalized lipid nanoparticles for sepsis therapy171
Hypoxia-responsive oncolytic conjugate triggers type-II immunogenic cell death for enhanced photodynamic immunotherapy169
Modified montmorillonite armed probiotics with enhanced on-site mucus-depleted intestinal colonization and H2S scavenging for colitis treatment166
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules165
Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice162
Combinatorial physical methods for cellular therapy: Towards the future of cellular analysis?161
Nanoghosts: Mesenchymal Stem cells derived nanoparticles as a unique approach for cartilage regeneration156
Mechanisms of uptake and transport of particulate formulations in the small intestine155
Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy148
Hybrid prodrug nanoassembly for hypoxia-triggered immunogenic chemotherapy and immune modulation147
Dynamic versus static testing and in vivo mechanical performance of poly(glycolide-trimethylene carbonate-ε-caprolactone) delayed release implants147
Down-regulation of TNF-α via macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis144
An efficient (nano) silica - In glucan particles protein encapsulation approach for improved thermal stability141
Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases139
Alendronate-functionalized polymeric micelles target icaritin to bone for mitigating osteoporosis in a rat model135
A next-generation STING agonist MSA-2: From mechanism to application134
Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?133
Identification of functional biomarkers for personalized nanomedicine in advanced breast cancer in vitro models131
Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications127
Transdermal carbon monoxide delivery125
Intraperitoneal drug delivery systems for peritoneal carcinomatosis: Bridging the gap between research and clinical implementation125
Combination of multivalent DR5 receptor clustering agonists and histone deacetylase inhibitors for treatment of colon cancer124
Outside Back Cover122
Hybrid nanopotentiators with dual cascade amplification for glioma combined interventional therapy121
Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation120
Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights120
Micellar paclitaxel boosts ICD and chemo-immunotherapy of metastatic triple negative breast cancer119
The colon targeting efficacies of mesalazine medications and their impacts on the gut microbiome119
Single-cell RNA transcriptome landscape of murine liver following systemic administration of mesoporous silica nanoparticles119
Healing with precision: A multi-functional hydrogel-bioactive glass dressing boosts infected wound recovery and enhances neurogenesis in the wound bed118
Cavitation-assisted sonothrombolysis by asymmetrical nanostars for accelerated thrombolysis117
Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis116
Impact of interferon-γ on the target cell tropism of nanoparticles116
In-situ-formed immunotherapeutic and hemostatic dual drug-loaded nanohydrogel for preventing postoperative recurrence of hepatocellular carcinoma115
Self-assembly hydrogels of therapeutic agents for local drug delivery114
Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability112
Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors109
Advance cardiac nanomedicine by targeting the pathophysiological characteristics of heart failure108
Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth107
Integrative approaches to enhance adeno-associated viral gene delivery107
Thermoresponsive polymeric dexamethasone prodrug for arthritis pain104
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence102
Autophagy-activating aluminum hydroxide nanovaccine for enhanced antigen presentation and anti-tumor immunity99
Dasatinib and erianin co-loaded ion-responsive in-situ hydrogel for effective treatment of corneal neovascularization98
Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy98
Multifunctional nanoparticles potentiate in-situ tumor vaccines via reversing insufficient Photothermal therapy by disrupting tumor vasculature98
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs97
Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy96
Injectable nanocomposite hydrogel with cascade drug release for treatment of uveal melanoma96
Orthogonal upconversion nanocarriers for combined photodynamic therapy and precisely triggered gene silencing in combating keloids95
ZIF-8-modified hydrogel sequentially delivers angiogenic and osteogenic growth factors to accelerate vascularized bone regeneration95
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy94
Tagged extracellular vesicles with the RBD of the viral spike protein for delivery of antiviral agents against SARS-COV-2 infection93
Autophagy-modulating biomembrane nanostructures: A robust anticancer weapon by modulating the inner and outer cancer environment93
MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration92
Oral mucosal vaccination using integrated fiber microneedles92
Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis90
Complement opsonization of nanoparticles: Differences between humans and preclinical species89
Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis88
Development of a thermostable oxytocin microneedle patch88
Bioorthogonal conjugation and responsive nanocoating of probiotics for inflammatory bowel disease88
Extracellular vesicles for renal therapeutics: State of the art and future perspective87
A smart cauliflower-like carrier for astaxanthin delivery to relieve colon inflammation87
White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin87
Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug87
Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients86
Dendritic cell derived exosomes loaded neoantigens for personalized cancer immunotherapies86
Melittin-incorporated nanomedicines for enhanced cancer immunotherapy86
Ferroptosis boosted oral cancer photodynamic therapy by carrier-free Sorafenib-Ce6 self-assembly nanoparticles85
An engineered dual function peptide to repair fractured bones85
Delivery of DNA octahedra enhanced by focused ultrasound with microbubbles for glioma therapy85
Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury84
Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives83
Inside Front Cover82
Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment82
Outside Front Cover82
Inside Back Cover81
Inside Back Cover81
Outside Front Cover80
Inside front cover: Yufan Qian et al80
Size matters: Altering antigen specific immune tolerance by tuning size of particles80
Thermal/ultrasound-triggered release of liposomes loaded with Ganoderma applanatum polysaccharide from microbubbles for enhanced tumour ablation79
Pre-mixing of omega-3 fatty acid-containing liposomes enhances the drug release rate and therapeutic efficacy of anticancer drugs loaded in liposomes79
Editorial Board79
Modulation of GABAergic neurons in acute epilepsy using sonogenetics78
Tet1 peptide and zinc (II)-adenine multifunctional module functionalized polycations as efficient siRNA carriers for Parkinson's disease78
Strengthening scientific credibility in the face of misinformation and disinformation: Viable solutions78
A polymer‑calcium phosphate nanocapsule for RNAi-induced oxidative stress and cascaded chemotherapy78
Exploration of M2 macrophage membrane as a biotherapeutic agent and strong synergistic therapeutic effects in ischemic stroke78
Low-boiling-point perfluorocarbon nanodroplets for adaptable ultrasound-induced blood-brain barrier opening77
Programmed T cells infiltration into lung metastases with harnessing dendritic cells in cancer immunotherapies by catalytic antigen-capture sponges76
Restoring tumor antigenicity activates the “bystander” T cell immune cycle76
Outside Back Cover: Yujie Wang et al75
Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential74
Corrigendum to “Size-specific clonidine-loaded liposomes: Advancing melanoma microenvironment suppression with safety and precision” [Journal of Controlled Release, Volume 379, 10 March 2025, Pages 1274
Nanoparticle-mediated synergistic disruption of tumor innervation and redox homeostasis for potent antineoplastic therapy73
Photothermal-controlled NO-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis73
Design of lipid-based formulations for oral delivery of a BASP1 peptide targeting MYC-dependent gastrointestinal cancer cells73
Linoleic acid co-administration promotes oral delivery of exenatide-loaded butyrate-decorated nanocapsules73
Corrigendum to “Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy” [Journal of Controlled Release 353 (2023) 447–461]72
Interplay between mucus mobility and alveolar macrophage targeting of surface-modified liposomes72
In situ formed reactive oxygen species-responsive dipyridamole prodrug hydrogel: Spatiotemporal drug delivery for chemoimmunotherapy71
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine71
Nano-engineered immune cells as “guided missiles” for cancer therapy71
Nano-chemical priming strategy to enhance TGF-β resistance and anti-tumor activity of natural killer cells71
Transitioning from a lab-scale PLGA microparticle formulation to pilot-scale manufacturing70
Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment70
An “IgG-hitchhiking” approach for rapid tumor accumulation and clearance of photosensitizers70
Orthogonal and complementary measurements of properties of drug products containing nanomaterials69
Protein-based delivery systems for RNA delivery69
Controlled release of manganese and magnesium ions by microsphere-encapsulated hydrogel enhances cancer immunotherapy69
An mRNA vaccine encoding proteasome-targeted antigen enhances CD8+ T cell immunity69
A preparation method for mRNA-LNPs with improved properties68
Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery efficiency to skin67
Engineered bacterial extracellular vesicles for central nervous system diseases67
Nanoadjuvants Actively targeting lymph node conduits and blocking tumor invasion in lymphatic vessels67
Nitroxide radical conjugated ovalbumin theranostic nanosystem for enhanced dendritic cell-based immunotherapy and T1 magnetic resonance imaging67
Chemo-photothermal nanoplatform with diselenide as the key for ferroptosis in colorectal cancer67
Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics67
A trinity STING-activating nanoparticle harnesses cancer cell STING machinery for enhanced immunotherapy67
Impact of injection sites on clinical pharmacokinetics of subcutaneously administered peptides and proteins67
An engineered α1β1 integrin-mediated FcγRI signaling component to control enhanced CAR macrophage activation and phagocytosis67
Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis66
Enhanced nose-to-brain delivery of siRNA using hyaluronan-enveloped nanomicelles for glioma therapy66
Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment66
Electrospun fibers for vaginal administration of tenofovir disoproxil fumarate and emtricitabine in the context of topical pre-exposure prophylaxis66
COG133 peptide-conjugated lipid nanoparticles sensitize medulloblastoma to radiation therapy in mice66
Dual-corn-derived nanofiber membrane for subconjunctival injury: Sequential release of dual-natural products for programmed anti-inflammation and anti-fibrosis66
AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges66
Acetyl-lysine human serum albumin nanoparticles activate CD44 receptors, with preferential uptake by cancer stem cells, leading to tumor eradication66
Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions66
Zeolite imidazolate framework-8 in bone regeneration: A systematic review65
Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer65
Advocation and advancements of EPR effect theory in drug delivery science: A commentary65
Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections65
Enhancing protective immunity against SARS-CoV-2 with a self-amplifying RNA lipid nanoparticle vaccine65
Ion-paired moxifloxacin nanocrystal formulation improves treatment and prevention of ocular infection65
Promotion or inhibition of extracellular vesicle release: Emerging therapeutic opportunities64
Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy64
Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension64
Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice64
Hyperglycemia-responsive nitric oxide-releasing biohybrid cryogels with cascade enzyme catalysis for enhanced healing of infected diabetic wounds64
A macrophage membrane-coated mesoporous silica nanoplatform inhibiting adenosine A2AR via in situ oxygen supply for immunotherapy64
Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route63
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity63
Gastrointestinally absorbable lactoferrin-heparin conjugate with anti-angiogenic activity for treatment of brain tumor63
Nanodrugs based on co-delivery strategies to combat cisplatin resistance63
Endoplasmic reticulum-targeted biomimetic nanoparticles induce apoptosis and ferroptosis by regulating endoplasmic reticulum function in colon cancer63
Editorial Board62
Tyrosine kinase inhibitor prodrug-loaded liposomes for controlled release at tumor microenvironment62
Strategic aspects for the commercialization of nanomedicines62
Macrophage membrane-encapsulated miRNA nanodelivery system for the treatment of hemophilic arthritis62
Potent inhibition of MMP-9 by a novel sustained-release platform attenuates left ventricular remodeling following myocardial infarction62
Treating colon cancers with a non-conventional yet strategic approach: An overview of various nanoparticulate systems60
In situ vaccine “seeds” for enhancing cancer immunotherapy by exploiting apoptosis-associated morphological changes60
Engineered macrophages acting as a trigger to induce inflammation only in tumor tissues60
Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats60
Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product60
Biomimetic-gasdermin-protein-expressing nanoplatform mediates tumor-specific pyroptosis for cancer immunotherapy59
DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics59
Prospects for hypoxia-based drug delivery platforms for the elimination of advanced metastatic tumors: From 3D modeling to clinical concepts58
Manganese-induced Photothermal-Ferroptosis for Synergistic Tumor Therapy58
GOx-encapsulated iron-phenolic networks power catalytic cascade to eradicate bacterial biofilms58
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer58
Next generation therapeutics for retinal neurodegenerative diseases57
Outside Front Cover57
Editorial Board57
Inside Back Cover57
LncRNA-edited biomimetic nanovaccines combined with anti-TIM-3 for augmented immune checkpoint blockade immunotherapy57
Outside Back Cover57
Inside Front Cover57
Platelet-mimicking supramolecular nanomedicine with precisely integrated prodrugs for cascade amplification of synergistic chemotherapy56
Corrigendum to “Ultrasound-responsive polymersomes capable of endosomal escape for efficient cancer therapy” [Journal of Controlled Release 322 (2020) 81–94]56
Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs56
All layers matter: Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes56
Nanoscale coordination polymers enabling antioxidants inhibition for enhanced chemodynamic therapy56
Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models56
Corrigendum to “Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery” [Journal of Controlled Release 55
Tiny tots for a big-league in wound repair: Tools for tissue regeneration by nanotechniques of today55
Modulating albumin-mediated transport of peptide-drug conjugates for antigen-specific Treg induction55
Augmented the sensitivity of photothermal-ferroptosis therapy in triple-negative breast cancer through mitochondria-targeted nanoreactor55
Splenic B cell-targeting lipid nanoparticles for safe and effective mRNA vaccine delivery55
Engineered vesicular cancer vaccines for immunosuppressive microenvironment reversion and in situ vaccine generation55
Ligand-installed polymeric nanocarriers for combination chemotherapy of EGFR-positive ovarian cancer55
Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis54
Shear force and cholesterol affinity responsive drug delivery system for treating inflammation and abnormal lipid metabolism in atherosclerosis54
A bionic “Trojan horse”-like gene delivery system hybridized with tumor and macrophage cell membrane for cancer therapy54
Nanoceria, the versatile nanoparticles: Promising biomedical applications54
Stimuli-responsive and biomimetic delivery systems for sepsis and related complications54
Bioengineered nanotechnology for nucleic acid delivery54
Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy54
A novel peptide hydrogel of metal ion clusters for accelerating bone defect regeneration54
Genetically engineered macrophages as living cell drug carriers for targeted cancer therapy54
Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features53
Influence of focused ultrasound on locoregional drug delivery to the brain: Potential implications for brain tumor therapy53
A glycopolymersome strategy for ‘drug-free’ treatment of diabetic nephropathy53
Micelle-to-Gel: Thermosensitive intra-articular hydrogels for osteoarthritis management53
Efficient pulmonary fibrosis therapy via regulating macrophage polarization using respirable cryptotanshinone-loaded liposomal microparticles53
A nanodrug combining CD47 and sonodynamic therapy efficiently inhibits osteosarcoma deterioration53
Microenvironment responsive charge-switchable nanoparticles act on biofilm eradication and virulence inhibition for chronic lung infection treatment53
An antigen-capturing and lymph node-targeting nanoparticle for cancer immunotherapy52
Determining topical product bioequivalence with stimulated Raman scattering microscopy52
The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency52
Locally delivered hydrogels with controlled release of nanoscale exosomes promote cardiac repair after myocardial infarction52
Self-adjuvanting polymeric nanovaccines enhance IFN production and cytotoxic T cell response52
Acid-base transformative HADLA micelles alleviate colitis by restoring adaptive immunity and gut microbiome52
Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer52
Hyaluronidase-powered microneedles for significantly enhanced transdermal delivery efficiency52
M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization52
Cell microencapsulation technologies for sustained drug delivery: Latest advances in efficacy and biosafety52
Intra-articular delivery of full-length antibodies through the use of an in situ forming depot52
Levodopa-loaded nanoparticles for the treatment of Parkinson's disease52
Gastrointestinal-inert prebiotic micro-composites improve the growth and community diversity of mucosal-associated bacteria.52
Multifunctional nanocomposite hydrogel with dual-factor controlled release for stem cell recruitment, immunomodulation and bone remodeling51
Construction of novel magnetic systems for cancer immunotherapy via cancer-immunity cycle circuits51
Reinforcing vascular normalization therapy with a bi-directional nano-system to achieve therapeutic-friendly tumor microenvironment51
Current state of the art in peptide-based gene delivery51
A bifunctional nanocomplex with remineralizing and antibacterial activities to interrupt dental caries51
Fine-tuning of liposome integrity for differentiated transcytosis and enhanced antitumor efficacy51
Recent advances in Bio-conjugated nanocarriers for crossing the Blood-Brain Barrier in (pre-)clinical studies with an emphasis on vesicles51
Glioma-derived exosomes hijack the blood–brain barrier to facilitate nanocapsule delivery via LCN251
Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II51
Vaccine nanodiscs plus polyICLC elicit robust CD8+ T cell responses in mice and non-human primates50
Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration50
Aptamer-conjugated nano-liposome for immunogenic chemotherapy with reversal of immunosuppression50
Combating cisplatin-resistant lung cancer using a coiled-coil lipopeptides modified membrane fused drug delivery system50
Protein-based nanocages for vaccine development50
Red blood cell-mimicking liposomes loading curcumin promote diabetic wound healing50
Enhancing pancreatic cancer immunotherapy: Leveraging localized delivery strategies through the use of implantable devices and scaffolds50
In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review50
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