Journal of Controlled Release

Papers
(The TQCC of Journal of Controlled Release is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)
ArticleCitations
Pickering emulsion-guided monomeric delivery of monophosphoryl lipid A for enhanced vaccination475
Hybrid prodrug nanoassembly for hypoxia-triggered immunogenic chemotherapy and immune modulation370
The pharmacokinetic profile of mitomycin C released from an injectable supramolecular hydrogel in a rodent model369
Collagenase-modified polydopamine nanoparticles for safe and effective vitreolysis337
Lanthanide nanocrystals-based direct triple-state energy converters for mitophagy and ferroptosis-induced antitumor immunoreaction328
Designing and modeling nanomedicines towards image-guided drug delivery in hematological malignancies318
Coordinated modulation of glucose metabolism and immunity via metal-drug nanovesicles for hepatocellular carcinoma therapy316
Outside Front Cover302
Hypoxia-responsive oncolytic conjugate triggers type-II immunogenic cell death for enhanced photodynamic immunotherapy289
Alendronate-functionalized polymeric micelles target icaritin to bone for mitigating osteoporosis in a rat model282
Oxygen-boosted fluorinated prodrug hybrid nanoassemblies for bidirectional amplification of breast cancer ferroptosis255
Optimized bacterial delivery approaches for precision immunotherapy in breast cancer models252
Nanoparticle-based methionine and AICAR delivery elicits a robust antitumor immune response241
Dasatinib and erianin co-loaded ion-responsive in-situ hydrogel for effective treatment of corneal neovascularization239
Inside Back Cover225
Corrigendum to “Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch” [Journal of Controlled Release 372 (2024) 304–317]222
Outside Back Cover217
Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy202
Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?190
Single-cell RNA transcriptome landscape of murine liver following systemic administration of mesoporous silica nanoparticles188
Outside Back Cover188
In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer188
A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine187
Impact of interferon-γ on the target cell tropism of nanoparticles185
Cavitation-assisted sonothrombolysis by asymmetrical nanostars for accelerated thrombolysis183
Combinatorial physical methods for cellular therapy: Towards the future of cellular analysis?183
MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration177
Unleashing the potential of cell biomimetic nanoparticles: Strategies and challenges in their design and fabrication for therapeutic applications158
An efficient (nano) silica - In glucan particles protein encapsulation approach for improved thermal stability156
Tumor permeable self-delivery nanodrug targeting mitochondria for enhanced chemotherapy155
The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair155
An engineered dual function peptide to repair fractured bones154
Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases147
Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy146
Prediction of drug capturing by lipid emulsions in vivo for the treatment of a drug overdose143
Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth139
Adaptable peptide-based therapeutics modulating tumor microenvironment for combinatorial radio-immunotherapy138
Integrative approaches to enhance adeno-associated viral gene delivery138
Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy138
Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability135
Modified montmorillonite armed probiotics with enhanced on-site mucus-depleted intestinal colonization and H2S scavenging for colitis treatment133
Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis132
Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction132
Extracellular vesicles for renal therapeutics: State of the art and future perspective131
Healing with precision: A multi-functional hydrogel-bioactive glass dressing boosts infected wound recovery and enhances neurogenesis in the wound bed128
Identification of functional biomarkers for personalized nanomedicine in advanced breast cancer in vitro models127
Autophagy-modulating biomembrane nanostructures: A robust anticancer weapon by modulating the inner and outer cancer environment123
Transdermal carbon monoxide delivery119
Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis118
Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice115
ZIF-8-modified hydrogel sequentially delivers angiogenic and osteogenic growth factors to accelerate vascularized bone regeneration112
Intraperitoneal drug delivery systems for peritoneal carcinomatosis: Bridging the gap between research and clinical implementation112
Bioorthogonal conjugation and responsive nanocoating of probiotics for inflammatory bowel disease110
In vivo delivery of antioxidant enzymes with multi-functionalized lipid nanoparticles for sepsis therapy109
Multifunctional delivery strategies and nanoplatforms of SN-38 in cancer therapeutics107
Autophagy-activating aluminum hydroxide nanovaccine for enhanced antigen presentation and anti-tumor immunity107
Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors107
Enhanced browning of adipose tissue by mirabegron-microspheres106
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence106
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3104
Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling104
Outside Front Cover: Yisheng Peng et al104
Dynamic versus static testing and in vivo mechanical performance of poly(glycolide-trimethylene carbonate-ε-caprolactone) delayed release implants103
Outside Back Cover101
Orthogonal upconversion nanocarriers for combined photodynamic therapy and precisely triggered gene silencing in combating keloids101
Combination of multivalent DR5 receptor clustering agonists and histone deacetylase inhibitors for treatment of colon cancer99
White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin97
Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury97
Multifunctional nanoparticles potentiate in-situ tumor vaccines via reversing insufficient Photothermal therapy by disrupting tumor vasculature97
Vascular endothelial cell-targeted mRNA delivery via synthetic lipid nanoparticles for venous thrombosis prevention96
Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy96
Biomaterial scaffolds for therapeutic immune cell engineering and delivery96
The inflammatory bowel disease and gut microbiome are restored by employing metformin-loaded alginate-shelled microcapsules96
Customization of protein corona to reprogram cancer nanomedicines: Mechanistic insights and therapeutic implications96
Injectable nanocomposite hydrogel with cascade drug release for treatment of uveal melanoma95
Melittin-incorporated nanomedicines for enhanced cancer immunotherapy94
Mechanism exploration of intestinal mucus penetration of nano-Se: regulated by polysaccharides with different functional groups and molecular weights93
Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug93
Metal-phenolic network-based polymeric nanocarriers facilitating antibody cytoplasmic delivery and anti-tumor effects to orthotopic breast tumors93
Thermoresponsive polymeric dexamethasone prodrug for arthritis pain93
Full-cycle study on developing a novel structured micromixer and evaluating the nanoparticle products as mRNA delivery carriers93
A next-generation STING agonist MSA-2: From mechanism to application92
Dendritic cell derived exosomes loaded neoantigens for personalized cancer immunotherapies92
Accelerated blood clearance of PEGylated nanoparticles induced by PEG-based pharmaceutical excipients92
Delivery of DNA octahedra enhanced by focused ultrasound with microbubbles for glioma therapy91
Micellar paclitaxel boosts ICD and chemo-immunotherapy of metastatic triple negative breast cancer91
A smart cauliflower-like carrier for astaxanthin delivery to relieve colon inflammation91
In-situ-formed immunotherapeutic and hemostatic dual drug-loaded nanohydrogel for preventing postoperative recurrence of hepatocellular carcinoma90
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes89
Ferroptosis boosted oral cancer photodynamic therapy by carrier-free Sorafenib-Ce6 self-assembly nanoparticles89
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs88
Mechanisms of uptake and transport of particulate formulations in the small intestine87
Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment86
Oral mucosal vaccination using integrated fiber microneedles86
The colon targeting efficacies of mesalazine medications and their impacts on the gut microbiome86
Self-assembly hydrogels of therapeutic agents for local drug delivery86
Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis85
Complement opsonization of nanoparticles: Differences between humans and preclinical species85
Hybrid nanopotentiators with dual cascade amplification for glioma combined interventional therapy85
Inside front cover: Yufan Qian et al84
Outside Back Cover: Yujie Wang et al84
Photothermal-controlled NO-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis84
Editorial Board84
Corrigendum to “Size-specific clonidine-loaded liposomes: Advancing melanoma microenvironment suppression with safety and precision” [Journal of Controlled Release, Volume 379, 10 March 2025, Pages 1284
Restoring tumor antigenicity activates the “bystander” T cell immune cycle84
Nanoparticle-mediated synergistic disruption of tumor innervation and redox homeostasis for potent antineoplastic therapy84
Endoplasmic reticulum-targeted biomimetic nanoparticles induce apoptosis and ferroptosis by regulating endoplasmic reticulum function in colon cancer83
Modulation of GABAergic neurons in acute epilepsy using sonogenetics83
Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery efficiency to skin81
Nitroxide radical conjugated ovalbumin theranostic nanosystem for enhanced dendritic cell-based immunotherapy and T1 magnetic resonance imaging81
Enhancing protective immunity against SARS-CoV-2 with a self-amplifying RNA lipid nanoparticle vaccine81
Hyperglycemia-responsive nitric oxide-releasing biohybrid cryogels with cascade enzyme catalysis for enhanced healing of infected diabetic wounds80
Exploration of M2 macrophage membrane as a biotherapeutic agent and strong synergistic therapeutic effects in ischemic stroke78
Linoleic acid co-administration promotes oral delivery of exenatide-loaded butyrate-decorated nanocapsules78
Dual-corn-derived nanofiber membrane for subconjunctival injury: Sequential release of dual-natural products for programmed anti-inflammation and anti-fibrosis78
Molecular engineering of extracellular vesicles for drug delivery: Strategies, challenges, and perspectives77
Chemo-photothermal nanoplatform with diselenide as the key for ferroptosis in colorectal cancer77
Programmable hierarchical hydrogel dressing for sequential release of growth factor and DNase to accelerate diabetic wound healing77
Pre-mixing of omega-3 fatty acid-containing liposomes enhances the drug release rate and therapeutic efficacy of anticancer drugs loaded in liposomes77
Outside Front Cover77
Multimodal nanoparticles co-delivering bevacizumab and dichloroacetate for dual targeting of neoangiogenesis and hyperglycolysis in glioblastoma treatment76
Unleashing the power of nucleic acid therapeutics through efficient cytosolic delivery76
Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates76
Inside Front Cover76
Ion-paired moxifloxacin nanocrystal formulation improves treatment and prevention of ocular infection75
Inorganic nanomaterials for drug delivery and therapeutic applications: Promise, pitfalls, and publication standards in Journal of Controlled Release75
An mRNA vaccine encoding proteasome-targeted antigen enhances CD8+ T cell immunity75
Design of lipid-based formulations for oral delivery of a BASP1 peptide targeting MYC-dependent gastrointestinal cancer cells75
In situ formed reactive oxygen species-responsive dipyridamole prodrug hydrogel: Spatiotemporal drug delivery for chemoimmunotherapy75
Injectable thermosensitive hydrogel for local and controlled delivery of siRNA-STAT3 polyplexes to treat advanced-stage ovarian cancer74
A trinity STING-activating nanoparticle harnesses cancer cell STING machinery for enhanced immunotherapy74
Clinically relevant dosing of miR-145 micelles curbs atherosclerosis in vivo73
Controlled release of manganese and magnesium ions by microsphere-encapsulated hydrogel enhances cancer immunotherapy73
Size matters: Altering antigen specific immune tolerance by tuning size of particles73
Corrigendum to “Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy” [Journal of Controlled Release 353 (2023) 447–461]72
Low-boiling-point perfluorocarbon nanodroplets for adaptable ultrasound-induced blood-brain barrier opening72
Strengthening scientific credibility in the face of misinformation and disinformation: Viable solutions72
Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis72
Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential72
Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer71
Inside Front Cover71
Thermal/ultrasound-triggered release of liposomes loaded with Ganoderma applanatum polysaccharide from microbubbles for enhanced tumour ablation71
Nano-engineered immune cells as “guided missiles” for cancer therapy70
Outside Front Cover70
AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges70
Outside Front Cover69
Nano-chemical priming strategy to enhance TGF-β resistance and anti-tumor activity of natural killer cells69
Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions69
Programmed T cells infiltration into lung metastases with harnessing dendritic cells in cancer immunotherapies by catalytic antigen-capture sponges69
Inside Back Cover69
Inside Back Cover69
Protein-based delivery systems for RNA delivery68
Interplay between mucus mobility and alveolar macrophage targeting of surface-modified liposomes68
A macrophage membrane-coated mesoporous silica nanoplatform inhibiting adenosine A2AR via in situ oxygen supply for immunotherapy68
Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy67
A polymer‑calcium phosphate nanocapsule for RNAi-induced oxidative stress and cascaded chemotherapy67
Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections67
Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route67
Engineered bacterial extracellular vesicles for central nervous system diseases67
Advocation and advancements of EPR effect theory in drug delivery science: A commentary67
Zeolite imidazolate framework-8 in bone regeneration: A systematic review66
Tet1 peptide and zinc (II)-adenine multifunctional module functionalized polycations as efficient siRNA carriers for Parkinson's disease66
Orthogonal and complementary measurements of properties of drug products containing nanomaterials66
Enhanced nose-to-brain delivery of siRNA using hyaluronan-enveloped nanomicelles for glioma therapy66
Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice65
Promotion or inhibition of extracellular vesicle release: Emerging therapeutic opportunities65
Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension65
Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics65
Nanoadjuvants Actively targeting lymph node conduits and blocking tumor invasion in lymphatic vessels65
Transitioning from a lab-scale PLGA microparticle formulation to pilot-scale manufacturing64
Acetyl-lysine human serum albumin nanoparticles activate CD44 receptors, with preferential uptake by cancer stem cells, leading to tumor eradication64
A preparation method for mRNA-LNPs with improved properties64
Gastrointestinally absorbable lactoferrin-heparin conjugate with anti-angiogenic activity for treatment of brain tumor63
Stimulator of interferon genes-targeted positron emission tomography tracks early microbiota-induced tumor immune remodeling and guides immunotherapy63
Combating cisplatin-resistant lung cancer using a coiled-coil lipopeptides modified membrane fused drug delivery system63
Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer63
Strategies of tea polyphenol-mediated delivery systems based on Mannich reaction for precision nutrition63
An “IgG-hitchhiking” approach for rapid tumor accumulation and clearance of photosensitizers63
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine63
Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment63
Multifunctional mPDA@Mel-AB/BG hydrogels: Integrating ROS scavenging, inflammation suppression, and cartilage repair for osteoarthritis therapy63
Reversible opening of the blood-labyrinth barrier by low-pressure pulsed ultrasound and microbubbles for the treatment of inner ear diseases63
Nanodrugs based on co-delivery strategies to combat cisplatin resistance63
An engineered α1β1 integrin-mediated FcγRI signaling component to control enhanced CAR macrophage activation and phagocytosis63
Editorial Board63
Hierarchically structured hydrogel exhibiting spatiotemporal release profiles: Enabling digital remote diagnosis and personalized therapeutics63
LIPUS-responsive meropenem-loaded nanobubbles enable biofilm disruption and bone repair in orthopedic implant-associated infections63
Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment63
COG133 peptide-conjugated lipid nanoparticles sensitize medulloblastoma to radiation therapy in mice63
Efficient pulmonary fibrosis therapy via regulating macrophage polarization using respirable cryptotanshinone-loaded liposomal microparticles62
Cross-linked selenolipoic acid nanoplatform modulates intracellular and extracellular reactive oxygen species for cancer immunotherapy62
Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery62
Engineered vesicular cancer vaccines for immunosuppressive microenvironment reversion and in situ vaccine generation61
In memoriam: Professor Rimona Margalit (1941–2024)61
Manganese-induced Photothermal-Ferroptosis for Synergistic Tumor Therapy61
Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs61
Corrigendum to “Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery” [Journal of Controlled Release 61
Fine-tuning of liposome integrity for differentiated transcytosis and enhanced antitumor efficacy60
Corrigendum to “Ultrasound-responsive polymersomes capable of endosomal escape for efficient cancer therapy” [Journal of Controlled Release 322 (2020) 81–94]60
Construction of novel magnetic systems for cancer immunotherapy via cancer-immunity cycle circuits60
A glycopolymersome strategy for ‘drug-free’ treatment of diabetic nephropathy60
Shear force and cholesterol affinity responsive drug delivery system for treating inflammation and abnormal lipid metabolism in atherosclerosis60
In situ vaccine “seeds” for enhancing cancer immunotherapy by exploiting apoptosis-associated morphological changes60
A bifunctional nanocomplex with remineralizing and antibacterial activities to interrupt dental caries60
An antigen-capturing and lymph node-targeting nanoparticle for cancer immunotherapy59
Editorial Board59
Gastrointestinal-inert prebiotic micro-composites improve the growth and community diversity of mucosal-associated bacteria.59
Multifunctional nanocomposite hydrogel with dual-factor controlled release for stem cell recruitment, immunomodulation and bone remodeling59
Inside Front Cover59
Cardiosplenic axis-targeted immunomodulatory liposome for myocardial ischemia-reperfusion injury treatment59
Outside Front Cover59
Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II58
Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features58
Next generation therapeutics for retinal neurodegenerative diseases58
LncRNA-edited biomimetic nanovaccines combined with anti-TIM-3 for augmented immune checkpoint blockade immunotherapy58
Biomimetic-gasdermin-protein-expressing nanoplatform mediates tumor-specific pyroptosis for cancer immunotherapy58
Ligand-installed polymeric nanocarriers for combination chemotherapy of EGFR-positive ovarian cancer58
A novel peptide hydrogel of metal ion clusters for accelerating bone defect regeneration57
Nanoscale coordination polymers enabling antioxidants inhibition for enhanced chemodynamic therapy57
Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats57
Microenvironment responsive charge-switchable nanoparticles act on biofilm eradication and virulence inhibition for chronic lung infection treatment57
A bionic “Trojan horse”-like gene delivery system hybridized with tumor and macrophage cell membrane for cancer therapy56
Levodopa-loaded nanoparticles for the treatment of Parkinson's disease56
Platelet-mimicking supramolecular nanomedicine with precisely integrated prodrugs for cascade amplification of synergistic chemotherapy56
Acid-base transformative HADLA micelles alleviate colitis by restoring adaptive immunity and gut microbiome55
Tiny tots for a big-league in wound repair: Tools for tissue regeneration by nanotechniques of today55
Potent inhibition of MMP-9 by a novel sustained-release platform attenuates left ventricular remodeling following myocardial infarction55
Influence of focused ultrasound on locoregional drug delivery to the brain: Potential implications for brain tumor therapy55
Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer54
Modulating albumin-mediated transport of peptide-drug conjugates for antigen-specific Treg induction54
Engineered macrophages acting as a trigger to induce inflammation only in tumor tissues54
Splenic B cell-targeting lipid nanoparticles for safe and effective mRNA vaccine delivery54
Determining topical product bioequivalence with stimulated Raman scattering microscopy54
Strategic aspects for the commercialization of nanomedicines54
DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics53
High-density lipoprotein in Alzheimer's disease: From potential biomarkers to therapeutics53
Reinforcing vascular normalization therapy with a bi-directional nano-system to achieve therapeutic-friendly tumor microenvironment53
Stimuli-responsive and biomimetic delivery systems for sepsis and related complications53
Hyaluronidase-powered microneedles for significantly enhanced transdermal delivery efficiency53
Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product52
Tyrosine kinase inhibitor prodrug-loaded liposomes for controlled release at tumor microenvironment52
Curcumin-release antibacterial dressings with antioxidation and anti-inflammatory function for diabetic wound healing and glucose monitoring52
All layers matter: Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes52
Protein-based nanocages for vaccine development52
Aptamer-conjugated nano-liposome for immunogenic chemotherapy with reversal of immunosuppression52
Micelle-to-Gel: Thermosensitive intra-articular hydrogels for osteoarthritis management52
Glioma-derived exosomes hijack the blood–brain barrier to facilitate nanocapsule delivery via LCN252
Prospects for hypoxia-based drug delivery platforms for the elimination of advanced metastatic tumors: From 3D modeling to clinical concepts52
Intra-articular delivery of full-length antibodies through the use of an in situ forming depot52
Current state of the art in peptide-based gene delivery51
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