Trends in Genetics

Article	Citations
Subscription and Copyright Information	681
Advisory Board and Contents	655
Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains	558
Advisory Board and Contents	240
Advisory Board and Contents	194
Genetic buffering mechanisms in SNF2-family translocases	171
Epigenetic networks driving T cell identity and plasticity during immunosenescence	168
Carcinoscorpius rotundicauda (mangrove horseshoe crab)	166
Omics studies of DNA G-/C-quadruplexes in plants	153
Assessing autosomal aneuploidy in ancient genomes	133
Superspreading in the emergence of COVID-19 variants	123
Genomic instability signals offer diagnostic possibility in early cancer detection	119
Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans	112
PCNA cycling dynamics during DNA replication and repair in mammals	112
The sound of silence: mechanisms and implications of HUSH complex function	100
Emerging functions of circular RNA in aging	91
Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries	88
The complex universe of inactive PARP1	83
Intron retention: importance, challenges, and opportunities	82
Pursuing totipotency: authentic totipotent stem cells in culture	79
Advisory Board and Contents	77
Opportunities and challenges for artificial intelligence in clinical cardiovascular genetics	73
Variation on a theme: mapping microglial heterogeneity	73
A new hypothesis to explain disease dominance	72
A three-dimensional genomics view for speciation research	70

The molecular evolutionary basis of species formation revisited	68
Multi-omic genetic scores advance disease research	67
Immunity and lifespan: answering long-standing questions with comparative genomics	66
m6A in the coding sequence: linking deposition, translation, and decay	63
Evolution of piRNA-guided defense against transposable elements	63
The chromatin roots of abnormal splicing in autism	61
Genome structural variation in human evolution	60
Histone lactylation: epigenetic mark of glycolytic switch	60
Advisory Board and Contents	59
Clonal ants reveal a potentially hidden meiotic feature	57
Revealing microRNA regulation in single cells	55
The making and breaking of tRNAs by ribonucleases	54
Subscription and Copyright Information	54
Canis familiaris (Great Dane domestic dog)	54
Advisory Board and Contents	54
Animal origins: looping back in time	52
Progress and opportunities through use of genomics in animal production	52
Ionizing radiation damage and repair from 3D-genomic perspective	52
Cis to trans: small ORF functions emerging through evolution	51
Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability	50
Dynamics of the Streptomyces chromosome: chance and necessity	49
Finding functional microproteins	49
Toward DNA-based taxonomy of prokaryotes and microeukaryotes	48
Pioneer factors: roles and their regulation in development	48
Advisory Board and Contents	44
From genetic associations to genes: methods, applications, and challenges	44
DNA base editing in nuclear and organellar genomes	44
Genetic architecture of brain morphology and overlap with neuropsychiatric traits	42
Subscription and Copyright Information	41
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Does TFIIH move nucleosomes?	40
Leveraging microbiome information for animal genetic improvement	39
Unraveling the diversity and cultural heritage of fruit crops through paleogenomics	38
Subscription and Copyright Information	38
Extracellular vesicles as modifiers of epigenomic profiles	37
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation	37
Protist genomics: key to understanding eukaryotic evolution	37
Wheat genomics: genomes, pangenomes, and beyond	37
Exploring the world of small proteins in plant biology and bioengineering	37
Advisory Board and Contents	36
mRNA-binding proteins and cell cycle progression	36
Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells	35
Advisory Board and Contents	33
Dissecting super-enhancer heterogeneity: time to re-examine cancer subtypes?	33
Mapping cellular responses to DNA double-strand breaks using CRISPR technologies	31
A current guide to candidate gene association studies	31
Callithrix jacchus (the common marmoset)	31
Open practices in our science and our courtrooms	31
The origins and evolution of translation factors	31
Earth Biogenome Project: present status and future plans	31

Mendel elucidated: Big Science comes to the humble garden pea	31
There is another: H3K27me3-mediated genomic imprinting	30
Directing RNA-modifying machineries towards endogenous RNAs: opportunities and challenges	30
Singling out motor neurons in the age of single-cell transcriptomics	29
Positive-strand RNA virus genome replication organelles: structure, assembly, control	29
Clonal selection parallels between normal and cancer tissues	29
Rare variants and handedness: spotlight on TUBB4B	28
Convergent evolution for antibiotic biosynthesis in bacteria and animals	28
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Evolving a favorable distribution for mutation effects	27
Cocos nucifera (coconut)	27
Research and leaders: a twisted tale!	27
Sleeping less with a SIK3 mutation	26
Clocks at sea: the genome-editing tide is rising	26
Low-cost CRISPR diagnostics for resource-limited settings	26
Architectural RNAs: blueprints for functional membraneless organelle assembly	26
The influence of transposable elements on animal colouration	25
Molecular circuits for genomic recording of cellular events	25
The H2A.Z-nucleosome code in mammals: emerging functions	25
Dosage compensation in non-model insects – progress and perspectives	25
Mitochondrial-derived microproteins: from discovery to function	24
Complex genomic rearrangements: an underestimated cause of rare diseases	24
Genetics of human handedness: microtubules and beyond	24
Beyond sequencing: machine learning algorithms extract biology hidden in Nanopore signal data	24
The cell as a bag of RNA	24
Chromoanagenesis in plants: triggers, mechanisms, and potential impact	24
Advisory Board and Contents	23
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Subscription and Copyright Information	22
The impact of IDR phosphorylation on the RNA binding profiles of proteins	22
Is it time to reassess variant annotation?	22
A new Down syndrome rat model races forward	22
In search of a cure: PACS1 Research Foundation as a model of rare disease therapy development	22
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Complexities of mammalian transcriptome revealed by targeted RNA enrichment techniques	22
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The versatile relationships between eIF4E and eIF4E-interacting proteins	21
Emerging insights into the genetics and evolution of human same-sex sexual behavior	21
The rare-to-common disease journey: a winding road to new therapies	21
Pathway-level convergence: an underexplored aspect of convergent evolution	21
Current concepts, advances, and challenges in deciphering the human microbiota with metatranscriptomics	21
Tissue specificity of DNA repair: the CRISPR compass	21
Into the multiverse: advances in single-cell multiomic profiling	20
The essential but enigmatic regulatory role of HERVH in pluripotency	20
Predicting genome organisation and function with mechanistic modelling	20
Integration of DNA damage responses with dynamic spatial genome organization	20
Advisory Board and Contents	20
Repetitive elements in aging and neurodegeneration	20
Long-read transcriptome sequencing reveals allele-specific variants at high resolution	20
Across the North Sea and beyond	19
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Advisory Board and Contents	19
The ribosome’s comeback: new role in body weight regulation	18
Subscription and Copyright Information	18
The genome atlas: navigating a new era of reference genomes	18
Are phenome-wide association studies feasible in a developing country?	18
DNA lesions piece together impossible trees	18
Bear essentials	18
Dynamics of replication timing during mammalian development	18
Zebrafish and idiopathic scoliosis: the ‘unknown knowns’	17
Quantitative genetics: pan-genomes, SVs, and k-mers for GWAS	17
Genomic newborn screening: exploring opportunities and navigating pitfalls while ensuring inclusivity	17
Mitochondria and G-quadruplex evolution: an intertwined relationship	17
Cross-kingdom RNA communication in plant–bacterial interaction	17
Noncanonical DNA structures are drivers of genome evolution	16
Emerging functions of mitochondria-encoded noncoding RNAs	16
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges	16
Genome stability from the perspective of telomere length	16
DNA methylation: a historical perspective	16
Computational methods for allele-specific expression in single cells	16
Subscription and Copyright Information	16
Advisory Board and Contents	15
Honeybees’ novel complementary sex-determining system: function and origin	15
Maturation and application of phenome-wide association studies	15
The wild side of grape genomics	15
The searchable chromosome	15
Modeling the origin of cells	15
Approaches and challenges in genome-wide circular RNA identification and quantification	14

Optimizing homology-directed repair for gene editing: the potential of single-stranded DNA donors	14
Insights from multi-omics integration in complex disease primary tissues	14
Chromatin accessibility provides a window into the genetic etiology of human brain disease	14
Opportunities and tradeoffs in single-cell transcriptomic technologies	14
Whole-genome doubling in tissues and tumors	14
Mitochondrial-derived microproteins: from discovery to function	14
Advancing evolutionary medicine with complete primate genomes and advanced biotechnologies	13
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Advisory Board and Contents	13
Advisory Board and Contents	13
Advisory Board and Contents	13
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Noncoding snoRNA host genes are a distinct subclass of long noncoding RNAs	12
Finding genes and pathways that underlie coral adaptation	12
ATRX, a guardian of chromatin	12
Spatial omics enters the microscopic realm: opportunities and challenges	12
Intragenomic mutational heterogeneity: structural and functional insights from gene evolution	12
Yes, polygenic sex determination is a thing!	12
Genetic adaptations for the oceanic success of fish eggs	12
Breakage in breakage–fusion–bridge cycle: an 80-year-old mystery	12
iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies	12
Chromatin-centric insights into DNA replication	11
Epigenetic perspectives on wheat speciation, adaptation, and development	11
Advisory Board and Contents	11
Selective REcruitmeNt of plant DNA polymerases by geminivirus	11
Subscription and Copyright Information	11
Every gene can (and possibly will) be associated with cancer	11
New insights into oocyte cytoplasmic lattice-associated proteins	10
Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome	10
An updated view of the kinetochore architecture	10
Genetic and epigenetic defects of the RNA modification machinery in cancer	10
A multi-epigenomic map of endurance exercise training	10
Starships: a new frontier for fungal biology	10
Cis-regulatory dynamics in plant domestication	10
Interruptions impact clinical features of repeat expansion diseases, but how are they gained and lost?	10
ReNU syndrome – a newly discovered prevalent neurodevelopmental disorder	10
Interplay between regulatory elements and chromatin topology in cellular lineage determination	10
Aneuploidy in human cancer: new tools and perspectives	10
ADAR1 and its implications in cancer development and treatment	9
Fun-sized and fundamental	9
Chromosome-scale haplotype-resolved pangenomics	9
People with disability and privacy in precision medicine research: what’s at stake?	9
miRNA biogenesis and inherited disorders: clinico-molecular insights	9
Advisory Board and Contents	9
A blood drop through the pore: nanopore sequencing in hematology	9
Advances in methods for tRNA sequencing and quantification	9
Subscription and Copyright Information	9
Cats – telomere to telomere and nose to tail	9
Genetic disorders of cellular trafficking	9
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FIRRM and FIGNL1: partners in the regulation of homologous recombination	8
Emerging links between phase separation and transcription factor haploinsufficiency	8
Functional characterization of human genomic variation linked to polygenic diseases	8
Evolutionary cell type mapping with single-cell genomics	8
Contributions of epigenomic and epitranscriptomic methylation to animal colouration	8
A dive into the unknome	8
Advisory Board and Contents	8
Leveraging spatial multiomics to unravel tissue architecture in embryo development	8
Haldane’s duel: intragenomic conflict, selfish Y chromosomes and speciation	8
Transposon–host arms race: a saga of genome evolution	8
Subscription and Copyright Information	8
Molecular animations in genomics education: designing for whom?	8
Duplicated gene networks promote ‘hopeful’ phenotypic variation	8
The impact of human accelerated regions on neuronal development	8
Recent insights into eukaryotic double-strand DNA break repair unveiled by single-molecule methods	8
Take a walk on the KRAB side	8
Patient privacy in AI-driven omics methods	7
Out of the dark: the emerging roles of lncRNAs in pain	7
From darkness to discovery: evolutionary, adaptive, and translational genetic insights from cavefish	7
Gene-dosage issues: a recurrent theme in whole genome duplication events	7
DEAD/DEAH-box RNA helicases shape the risk of neurodevelopmental disorders	7
The evolution of the GALactose utilization pathway in budding yeasts	7
Advisory Board and Contents	6
Time is ticking faster for long genes in aging	6
Achieve your research goals: a project management toolkit for graduate studies	6
Multiple sclerosis: doubling down on MHC	6
Gene reporters for magnetic resonance imaging	6
Studying transcription factor function in the genome at molecular resolution	6
Epigenetic control of muscle stem cells: time for a new dimension	6
Advisory Board and Contents	6
Genetic and epigenetic landscape of male infertility	6
Bridging biological cfDNA features and machine learning approaches	6
Aegilops tauschii presents a genetic roadmap for hexaploid wheat improvement	6
Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy	6
Structure-specific nucleases: role in Okazaki fragment maturation	6
Retrotransposon renaissance in early embryos	6
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Unraveling brain complexity: from single-cell to spatial m6A technologies	6
Preventing excess replication origin activation to ensure genome stability	6
HMGs as rheostats of chromosomal structure and cell proliferation	6
Picochlorum sp. SENEW3	6
The evolution of aging and lifespan	6
RNAPII driven post-translational modifications of nucleosomal histones	6
Exploring the role of phage plasmids in gene transfers	5
Advisory Board and Contents	5