Trends in Genetics

Article	Citations
Subscription and Copyright Information	607
Advisory Board and Contents	579
Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains	474
Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries	257
Subscription and Copyright Information	202
Advisory Board and Contents	176
Advisory Board and Contents	170
Genomic instability signals offer diagnostic possibility in early cancer detection	160
Genetic buffering mechanisms in SNF2-family translocases	155
Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity	147
Emerging functions of circular RNA in aging	145
The complex universe of inactive PARP1	140
Pursuing totipotency: authentic totipotent stem cells in culture	133
Epigenetic networks driving T cell identity and plasticity during immunosenescence	119
Carcinoscorpius rotundicauda (mangrove horseshoe crab)	116
Omics studies of DNA G-/C-quadruplexes in plants	108
Assessing autosomal aneuploidy in ancient genomes	105
Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans	101
PCNA cycling dynamics during DNA replication and repair in mammals	100
Superspreading in the emergence of COVID-19 variants	96
The sound of silence: mechanisms and implications of HUSH complex function	88
Intron retention: importance, challenges, and opportunities	81
Advisory Board and Contents	80
Opportunities and challenges for artificial intelligence in clinical cardiovascular genetics	78
Variation on a theme: mapping microglial heterogeneity	78

A new hypothesis to explain disease dominance	73
Multi-omic genetic scores advance disease research	72
Immunity and lifespan: answering long-standing questions with comparative genomics	70
Evolution of piRNA-guided defense against transposable elements	70
Genome structural variation in human evolution	69
The chromatin roots of abnormal splicing in autism	67
A three-dimensional genomics view for speciation research	67
Histone lactylation: epigenetic mark of glycolytic switch	66
Advisory Board and Contents	64
Clonal ants reveal a potentially hidden meiotic feature	62
Advisory Board and Contents	59
Subscription and Copyright Information	59
The making and breaking of tRNAs by ribonucleases	58
Cis to trans: small ORF functions emerging through evolution	58
Dynamics of the Streptomyces chromosome: chance and necessity	54
Ionizing radiation damage and repair from 3D-genomic perspective	52
Finding functional microproteins	52
Canis familiaris (Great Dane domestic dog)	51
Progress and opportunities through use of genomics in animal production	48
Revealing microRNA regulation in single cells	48
DNA base editing in nuclear and organellar genomes	48
Pioneer factors: roles and their regulation in development	47
From genetic associations to genes: methods, applications, and challenges	47
Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability	47
Genetic architecture of brain morphology and overlap with neuropsychiatric traits	46
Advisory Board and Contents	46
Subscription and Copyright Information	45
Subscription and Copyright Information	45
Exploring the world of small proteins in plant biology and bioengineering	45
Leveraging microbiome information for animal genetic improvement	44
Unraveling the diversity and cultural heritage of fruit crops through paleogenomics	44
Extracellular vesicles as modifiers of epigenomic profiles	42
Does TFIIH move nucleosomes?	42
Wheat genomics: genomes, pangenomes, and beyond	40
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation	40
mRNA-binding proteins and cell cycle progression	39
Callithrix jacchus (the common marmoset)	39
The Nexus of cfDNA and Nuclease Biology	39
Advisory Board and Contents	38
Advisory Board and Contents	38
The origins and evolution of translation factors	37
Dissecting super-enhancer heterogeneity: time to re-examine cancer subtypes?	36
Earth Biogenome Project: present status and future plans	36
Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells	36
Positive-strand RNA virus genome replication organelles: structure, assembly, control	36
Directing RNA-modifying machineries towards endogenous RNAs: opportunities and challenges	35
A current guide to candidate gene association studies	35
Singling out motor neurons in the age of single-cell transcriptomics	34
Open practices in our science and our courtrooms	34
There is another: H3K27me3-mediated genomic imprinting	34

Transcriptional Silencers: Driving Gene Expression with the Brakes On	33
Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction	33
Mapping cellular responses to DNA double-strand breaks using CRISPR technologies	33
Clonal selection parallels between normal and cancer tissues	32
Low-cost CRISPR diagnostics for resource-limited settings	31
Subscription and Copyright Information	31
The influence of transposable elements on animal colouration	30
Clocks at sea: the genome-editing tide is rising	30
Convergent evolution for antibiotic biosynthesis in bacteria and animals	30
Cocos nucifera (coconut)	29
The cell as a bag of RNA	29
Research and leaders: a twisted tale!	29
Chromoanagenesis in plants: triggers, mechanisms, and potential impact	28
Molecular circuits for genomic recording of cellular events	27
Rare variants and handedness: spotlight on TUBB4B	27
Evolving a favorable distribution for mutation effects	27
Dosage compensation in non-model insects – progress and perspectives	27
Mitochondrial-derived microproteins: from discovery to function	26
Horizontal Gene Transfer in Vertebrates: A Fishy Tale	26
Complex genomic rearrangements: an underestimated cause of rare diseases	25
Genetics of human handedness: microtubules and beyond	25
The Curious Case of Avian Sex Determination	24
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Subscription and Copyright Information	24
Subscription and Copyright Information	24
Advisory Board and Contents	24
Beyond sequencing: machine learning algorithms extract biology hidden in Nanopore signal data	24
The H2A.Z-nucleosome code in mammals: emerging functions	24
A new Down syndrome rat model races forward	23
Is it time to reassess variant annotation?	23
Integration of DNA damage responses with dynamic spatial genome organization	22
Subscription and Copyright Information	22
The impact of IDR phosphorylation on the RNA binding profiles of proteins	22
Long-read transcriptome sequencing reveals allele-specific variants at high resolution	22
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Complexities of mammalian transcriptome revealed by targeted RNA enrichment techniques	22
Driving to Safety: CRISPR-Based Genetic Approaches to Reducing Antibiotic Resistance	22
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Emerging insights into the genetics and evolution of human same-sex sexual behavior	21
In search of a cure: PACS1 Research Foundation as a model of rare disease therapy development	21
Into the multiverse: advances in single-cell multiomic profiling	21
Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability	21
Current concepts, advances, and challenges in deciphering the human microbiota with metatranscriptomics	21
Predicting genome organisation and function with mechanistic modelling	21
The versatile relationships between eIF4E and eIF4E-interacting proteins	21
Tissue specificity of DNA repair: the CRISPR compass	21
Repetitive elements in aging and neurodegeneration	20
The essential but enigmatic regulatory role of HERVH in pluripotency	20
Dynamics of replication timing during mammalian development	19
Advisory Board and Contents	19
Are phenome-wide association studies feasible in a developing country?	19
Across the North Sea and beyond	19
Zebrafish and idiopathic scoliosis: the ‘unknown knowns’	19
Subscription and Copyright Information	19
Advisory Board and Contents	19
Bear essentials	18
Computational methods for allele-specific expression in single cells	18
The genome atlas: navigating a new era of reference genomes	18
The ribosome’s comeback: new role in body weight regulation	18
Recursive Test of Hardy-Weinberg Equilibrium in Tetraploids	18
Genome stability from the perspective of telomere length	17
Genomic newborn screening: exploring opportunities and navigating pitfalls while ensuring inclusivity	17
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges	17
DNA lesions piece together impossible trees	17
Mitochondria and G-quadruplex evolution: an intertwined relationship	17
Quantitative genetics: pan-genomes, SVs, and k-mers for GWAS	17
DNA methylation: a historical perspective	16
Noncanonical DNA structures are drivers of genome evolution	16
Whole-genome doubling in tissues and tumors	16
The searchable chromosome	16
Honeybees’ novel complementary sex-determining system: function and origin	16
Chromatin accessibility provides a window into the genetic etiology of human brain disease	16
Advisory Board and Contents	16
Emerging functions of mitochondria-encoded noncoding RNAs	16
Subscription and Copyright Information	16
Mitochondrial-derived microproteins: from discovery to function	16
Maturation and application of phenome-wide association studies	15
The wild side of grape genomics	15
Modeling the origin of cells	15
Approaches and challenges in genome-wide circular RNA identification and quantification	15

Opportunities and tradeoffs in single-cell transcriptomic technologies	15
Insights from multi-omics integration in complex disease primary tissues	15
Advisory Board and Contents	14
Optimizing homology-directed repair for gene editing: the potential of single-stranded DNA donors	14
Advancing evolutionary medicine with complete primate genomes and advanced biotechnologies	14
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Intragenomic mutational heterogeneity: structural and functional insights from gene evolution	14
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Genetic adaptations for the oceanic success of fish eggs	13
Breakage in breakage–fusion–bridge cycle: an 80-year-old mystery	13
Yes, polygenic sex determination is a thing!	13
Noncoding snoRNA host genes are a distinct subclass of long noncoding RNAs	13
Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome	12
Advisory Board and Contents	12
iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies	12
Subscription and Copyright Information	12
Advisory Board and Contents	12
Finding genes and pathways that underlie coral adaptation	12
Advances in methods for tRNA sequencing and quantification	12
ATRX, a guardian of chromatin	12
miRNA biogenesis and inherited disorders: clinico-molecular insights	11
Interplay between regulatory elements and chromatin topology in cellular lineage determination	11
Epigenetic perspectives on wheat speciation, adaptation, and development	11
Chromatin-centric insights into DNA replication	11
Cis-regulatory dynamics in plant domestication	11
Aneuploidy in human cancer: new tools and perspectives	11
New insights into oocyte cytoplasmic lattice-associated proteins	11
Every gene can (and possibly will) be associated with cancer	11
Nuclear Periphery and Telomere Maintenance: TERRA Joins the Stage	11
An updated view of the kinetochore architecture	10
Genetic and epigenetic defects of the RNA modification machinery in cancer	10
Advisory Board and Contents	10
ReNU syndrome – a newly discovered prevalent neurodevelopmental disorder	10
Selective REcruitmeNt of plant DNA polymerases by geminivirus	10
ADAR1 and its implications in cancer development and treatment	10
A multi-epigenomic map of endurance exercise training	10
Starships: a new frontier for fungal biology	10
Subscription and Copyright Information	10
Cats – telomere to telomere and nose to tail	9
Recent insights into eukaryotic double-strand DNA break repair unveiled by single-molecule methods	9
Take a walk on the KRAB side	9
Evolutionary cell type mapping with single-cell genomics	9
Fun-sized and fundamental	9
Chromosome-scale haplotype-resolved pangenomics	9
Genetic disorders of cellular trafficking	9
Contributions of epigenomic and epitranscriptomic methylation to animal colouration	9
People with disability and privacy in precision medicine research: what’s at stake?	9
Transposon–host arms race: a saga of genome evolution	9
A blood drop through the pore: nanopore sequencing in hematology	9
Subscription and Copyright Information	9
Emerging links between phase separation and transcription factor haploinsufficiency	8
The impact of human accelerated regions on neuronal development	8
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Haldane’s duel: intragenomic conflict, selfish Y chromosomes and speciation	8
Molecular animations in genomics education: designing for whom?	8
Leveraging spatial multiomics to unravel tissue architecture in embryo development	8
Out of the dark: the emerging roles of lncRNAs in pain	8
Advisory Board and Contents	8
Duplicated gene networks promote ‘hopeful’ phenotypic variation	8
FIRRM and FIGNL1: partners in the regulation of homologous recombination	8
Patient privacy in AI-driven omics methods	8
Gene-dosage issues: a recurrent theme in whole genome duplication events	8
The evolution of the GALactose utilization pathway in budding yeasts	8
DEAD/DEAH-box RNA helicases shape the risk of neurodevelopmental disorders	7
From darkness to discovery: evolutionary, adaptive, and translational genetic insights from cavefish	7
A dive into the unknome	7
Advisory Board and Contents	7
Functional characterization of human genomic variation linked to polygenic diseases	7
Time is ticking faster for long genes in aging	7
The New RNA-Editing Era – Ethical Considerations	7
Subscription and Copyright Information	7
Preventing excess replication origin activation to ensure genome stability	7
Bridging biological cfDNA features and machine learning approaches	7
Advisory Board and Contents	7
Multiple sclerosis: doubling down on MHC	7
Women and Minorities Encouraged to Apply (Not Stay)	6
Structure-specific nucleases: role in Okazaki fragment maturation	6
Strategies for dissecting the complexity of neurodevelopmental disorders	6
Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy	6
Therapeutic and prognostic insights from the analysis of cancer mutational signatures	6
Epigenetic control of muscle stem cells: time for a new dimension	6
The evolution of aging and lifespan	6
Retrotransposon renaissance in early embryos	6
Advisory Board and Contents	6
Translating the telomeres	6
Non-canonical functions of enhancers: regulation of RNA polymerase III transcription, DNA replication, and V(D)J recombination	6
Studying transcription factor function in the genome at molecular resolution	6
HMGs as rheostats of chromosomal structure and cell proliferation	6
RNAPII driven post-translational modifications of nucleosomal histones	6
The multifaceted effects of YTHDC1-mediated nuclear m6A recognition	6
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Alternative paths for genetics, then and now: Q&A with Gregory Radick about Disputed Inheritance	6
Picochlorum sp. SENEW3	6
Achieve your research goals: a project management toolkit for graduate studies	6
Exploring the Alternative Splicing of Long Noncoding RNAs	6