Trends in Genetics

Article	Citations
Navigating the DNA methylation landscape of cancer	304
Emerging concepts of miRNA therapeutics: from cells to clinic	215
Opening the Black Box: Interpretable Machine Learning for Geneticists	194
Advances in the Evolutionary Understanding of MHC Polymorphism	188
DNA methylation: a historical perspective	183
Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies	171
Where Are the Disease-Associated eQTLs?	160
What Is a Transcriptional Burst?	134
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing	128
To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases	121
Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation	107
Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability	99
Classical and noncanonical functions of miRNAs in cancers	93
Advances in Chromatin Imaging at Kilobase-Scale Resolution	89
Fast-forward breeding for a food-secure world	82
Horizontal Gene Transfer in Eukaryotes: Not if, but How Much?	82
Retention of duplicated genes in evolution	76
The Genomics of Human Local Adaptation	72
Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction	68
The Role of Noncoding Variants in Heritable Disease	67
The p53 network: cellular and systemic DNA damage responses in cancer and aging	66
The Nexus of cfDNA and Nuclease Biology	66
Anything but Ordinary – Emerging Splicing Mechanisms in Eukaryotic Gene Regulation	65
Hotspots of Human Mutation	64
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders	63

Forkhead Transcription Factors in Health and Disease	63
Towards a Human Cell Atlas: Taking Notes from the Past	60
Mitochondrial Diseases: A Diagnostic Revolution	59
Taming transposable elements in vertebrates: from epigenetic silencing to domestication	59
Relaxed Selection and the Rapid Evolution of Reproductive Genes	57
Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity	56
Extrachromosomal circular DNA in cancer: history, current knowledge, and methods	56
How genomics can help biodiversity conservation	55
The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway	55
Genetic prediction of complex traits with polygenic scores: a statistical review	55
The Epigenetic Drug Discovery Landscape for Metabolic-associated Fatty Liver Disease	53
New Approaches for Inferring Phylogenies in the Presence of Paralogs	49
Impact of Parental Exposure on Offspring Health in Humans	48
Functions of PIWI Proteins in Gene Regulation: New Arrows Added to the piRNA Quiver	48
On the Molecular Mechanisms Regulating Animal Cell Size Homeostasis	47
Termination of Transcription by RNA Polymerase II: BOOM!	47
Into the multiverse: advances in single-cell multiomic profiling	47
The multifaceted effects of YTHDC1-mediated nuclear m6A recognition	46
Host Polymorphisms May Impact SARS-CoV-2 Infectivity	45
Role of Polycomb in the control of transposable elements	45
Mitonuclear Compensatory Coevolution	44
Transcriptional Silencers: Driving Gene Expression with the Brakes On	44
Nonhomologous end joining: new accessory factors fine tune the machinery	44
Beyond sequencing: machine learning algorithms extract biology hidden in Nanopore signal data	43
Evolutionary cell type mapping with single-cell genomics	43
Transcriptional Regulation at DSBs: Mechanisms and Consequences	42
Mouse Systems Genetics as a Prelude to Precision Medicine	42
Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks	41
Histone lactylation: epigenetic mark of glycolytic switch	40
Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and Beyond	39
A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine	39
Epigenetic Regulators as the Gatekeepers of Hematopoiesis	39
Base Editing Landscape Extends to Perform Transversion Mutation	37
Therapeutic and prognostic insights from the analysis of cancer mutational signatures	37
A TAD Skeptic: Is 3D Genome Topology Conserved?	37
Speed–Specificity Trade-Offs in the Transcription Factors Search for Their Genomic Binding Sites	36
Insights from multi-omics integration in complex disease primary tissues	36
Catastrophic Endgames: Emerging Mechanisms of Telomere-Driven Genomic Instability	35
DNA Damage Triggers a New Phase in Neurodegeneration	35
Facilitating Complex Trait Analysis via Reduced Complexity Crosses	35
Emerging functions of circular RNA in aging	34
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation	34
ADAR1 and its implications in cancer development and treatment	33
The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins	33
Gene Regulation and Cellular Metabolism: An Essential Partnership	33
The Y Chromosome as a Battleground for Intragenomic Conflict	32
Genome structural variation in human evolution	32
Somatic mutations provide important and unique insights into the biology of complex diseases	32
Exploring the Alternative Splicing of Long Noncoding RNAs	32
Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases	32

APOBECs orchestrate genomic and epigenomic editing across health and disease	31
Molecular Clocks without Rocks: New Solutions for Old Problems	31
Superspreading in the emergence of COVID-19 variants	30
Plant Genetic Networks Shaping Phyllosphere Microbial Community	29
Evolution of Diverse Strategies for Promoter Regulation	29
Taming the Turmoil Within: New Insights on the Containment of Transposable Elements	29
Site-Specific Recombination – How Simple DNA Inversions Produce Complex Phenotypic Heterogeneity in Bacterial Populations	29
Symbionts and gene drive: two strategies to combat vector-borne disease	28
RNA Editing in Mitochondria and Plastids: Weird and Widespread	28
Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility	27
Bridging biological cfDNA features and machine learning approaches	26
Noncanonical DNA structures are drivers of genome evolution	26
Networks of Resistance: Small RNA Control of Antibiotic Resistance	26
From Summary Statistics to Gene Trees: Methods for Inferring Positive Selection	26
A devil's bargain with transposable elements in plant pathogens	26
Anticipating and Identifying Collateral Damage in Genome Editing	26
The era of 3D and spatial genomics	25
Every gene can (and possibly will) be associated with cancer	25
Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance	25
Deregulated Regulators: Disease-Causing cis Variants in Transcription Factor Genes	25
Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer	25
Intricacies of single-cell multi-omics data integration	25
State-of-the-art CRISPR for in vivo and cell-based studies in Drosophila	25
DNA Damage Response and Metabolic Reprogramming in Health and Disease	25
Principles of Epigenetic Homeostasis Shared Between Flowering Plants and Mammals	24
Optogenetics for transcriptional programming and genetic engineering	24
Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle	24
Epimutations Define a Fast-Ticking Molecular Clock in Plants	24
Genetic disorders of cellular trafficking	24
WRKY transcription factors in plant defense	23
DNA N6-methyldeoxyadenosine in mammals and human disease	23
Multiple sclerosis: doubling down on MHC	23
Elucidation of Biological Networks across Complex Diseases Using Single-Cell Omics	23
Advancing human disease research with fish evolutionary mutant models	22
The Toll gene in Drosophila pattern formation	22
Genetics and Epigenetics of Sex Bias: Insights from Human Cancer and Autoimmunity	22
Underappreciated Roles of DNA Polymerase δ in Replication Stress Survival	22
Emerging Insights into the Distinctive Neuronal Methylome	22
Quo vadis microRNAs?	22
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges	22
Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity	22
Horizontal Gene Transfer in Vertebrates: A Fishy Tale	21
All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics	21
Break-induced replication: unraveling each step	21
Monarch Butterfly Migration Moving into the Genetic Era	21
The H2A.Z-nucleosome code in mammals: emerging functions	21
Genetic Variation across Phenotypic Severity of Autism	20
Uncovering the impact of noncoding variants in neurodegenerative brain diseases	20
Mitochondrial genome engineering coming-of-age	20
Genetics in Light of Transcriptional Adaptation	20
Biosensing Detection of the SARS-CoV-2 D614G Mutation	20
Throwing away DNA: programmed downsizing in somatic nuclei	19
New Solutions to Old Problems: Molecular Mechanisms of Meiotic Crossover Control	19
Meiotic Executioner Genes Protect the Y from Extinction	19
A decade of molecular cell atlases	19
Emerging functions of mitochondria-encoded noncoding RNAs	19
The evolution of the GALactose utilization pathway in budding yeasts	19
Simple Repeats as Building Blocks for Genetic Computers	19
Unraveling the Epigenetic Basis of Liver Development, Regeneration and Disease	19
SWEET Genes for Disease Resistance in Plants	19
Complex genomic rearrangements: an underestimated cause of rare diseases	19
The PDE-Opathies: Diverse Phenotypes Produced by a Functionally Related Multigene Family	18
Intron retention: importance, challenges, and opportunities	18
Regulatory mechanisms ensuring coordinated expression of functionally related genes	18
Genetic and epigenetic defects of the RNA modification machinery in cancer	18
SpRY: Engineered CRISPR/Cas9 Harnesses New Genome-Editing Power	18
Evolutionary Conservation of Transcription Factors Affecting Longevity	18
Transcriptional and Epigenetic Regulation of Autophagy in Plants	18
Virus-Based CRISPR/Cas9 Genome Editing in Plants	17
Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites	17
Genetically transitional disease: a new concept in genomic medicine	16
The cell as a bag of RNA	16
'Fly-ing' from rare to common neurodegenerative disease mechanisms	16
There is another: H3K27me3-mediated genomic imprinting	16
Genetic Variants Affecting Skeletal Morphology in Domestic Dogs	15
Potato trait development going fast-forward with genome editing	15
Tissue specificity of DNA repair: the CRISPR compass	15
DNA base editing in nuclear and organellar genomes	15
Chromatin and Nuclear Architecture: Shaping DNA Replication in 3D	15
Biology in balance: human diploid genome integrity, gene dosage, and genomic medicine	15

Feralization: Confronting the Complexity of Domestication and Evolution	15
The sound of silence: mechanisms and implications of HUSH complex function	15