Advanced Drug Delivery Reviews

Article	Citations
Liposome composition in drug delivery design, synthesis, characterization, and clinical application	336
Self-assembled mRNA vaccines	253
COVID-19 vaccines: The status and perspectives in delivery points of view	251
The role of lipid components in lipid nanoparticles for vaccines and gene therapy	215
Supramolecular engineering of hydrogels for drug delivery	177
To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives	175
Overcoming barriers by local drug delivery with liposomes	172
Pharmaceutical electrospinning and 3D printing scaffold design for bone regeneration	166
DNA hydrogel-based gene editing and drug delivery systems	165
Recombinant protein vaccines, a proven approach against coronavirus pandemics	159
Non-viral COVID-19 vaccine delivery systems	155
Translating 3D printed pharmaceuticals: From hype to real-world clinical applications	151
Dosing extracellular vesicles	139
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers	137
RNAi-based therapeutics and tumor targeted delivery in cancer	134
Fibronectin in development and wound healing	133
Peptide and peptide-based inhibitors of SARS-CoV-2 entry	127
Frontiers in the treatment of glioblastoma: Past, present and emerging	127
Connected healthcare: Improving patient care using digital health technologies	126
Nucleic acid delivery for therapeutic applications	126
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation	126
Advances in powder bed fusion 3D printing in drug delivery and healthcare	125
Rational designs of in vivo CRISPR-Cas delivery systems	118
Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis	116
Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy	112

Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment	111
Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites	111
Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery	110
Clinical translation of nanomedicines: Challenges, opportunities, and keys	105
Antimicrobial peptides towards clinical application: Delivery and formulation	104
Machine learning directed drug formulation development	104
Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies	103
Peptide-based supramolecular hydrogels for local drug delivery	99
Nanoscale MOFs: From synthesis to drug delivery and theranostics applications	94
(Macro)molecular self-assembly for hydrogel drug delivery	93
Targeting drug delivery with light: A highly focused approach	93
Engineering the drug carrier biointerface to overcome biological barriers to drug delivery	92
Approaches to surface engineering of extracellular vesicles	92
Polymeric drug delivery systems by additive manufacturing	91
Emerging 3D printing technologies for drug delivery devices: Current status and future perspective	90
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies	89
Technology insight: Plant-derived vesicles—How far from the clinical biotherapeutics and therapeutic drug carriers?	89
Near-infrared fluorescence imaging in immunotherapy	89
Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment	87
Topical drug delivery: History, percutaneous absorption, and product development	87
Harnessing artificial intelligence for the next generation of 3D printed medicines	87
Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities	87
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network	85
Predicting bioavailability of monoclonal antibodies after subcutaneous administration: Open innovation challenge	83
Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases	83
Challenges of fused deposition modeling 3D printing in pharmaceutical applications: Where are we now?	81
Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis	81
The effects of protein corona on in vivo fate of nanocarriers	79
An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers	78
Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants	78
Biomedical engineering of two-dimensional MXenes	77
Microneedle-Mediated Vaccination: Innovation and Translation	77
Clinically established biodegradable long acting injectables: An industry perspective	77
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health	76
Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance	75
Let’s talk about sex: Differences in drug therapy in males and females	74
Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery	73
Delivery of STING agonists for adjuvanting subunit vaccines	72
Vaccine delivery systems toward lymph nodes	72
SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?	72
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives	72
Target specific tight junction modulators	72
Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems	71
Photodynamic and antibiotic therapy in combination against bacterial infections: efficacy, determinants, mechanisms, and future perspectives	71
Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic	71
Advances in gene-based vaccine platforms to address the COVID-19 pandemic	71
Why nanoparticles prefer liver macrophage cell uptake in vivo	69
A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos	69
Nanocarrier vaccines for SARS-CoV-2	69
Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms	68

Mesoporous silica nanoparticles for pulmonary drug delivery	68
Biomembrane-based nanostructures for cancer targeting and therapy: From synthetic liposomes to natural biomembranes and membrane-vesicles	68
Dawn of lipid nanoparticles in lymph node targeting: Potential in cancer immunotherapy	67
3D printing as a transformative tool for microneedle systems: Recent advances, manufacturing considerations and market potential	67
Imaging technology of the lymphatic system	66
Technological advances towards extracellular vesicles mass production	66
The past, present, and future of breast cancer models for nanomedicine development	66
Targeting the blood-brain barrier for the delivery of stroke therapies	65
Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis	65
Separation, characterization, and standardization of extracellular vesicles for drug delivery applications	65
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential	64
Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design	63
Shape memory materials and 4D printing in pharmaceutics	63
Scaled preparation of extracellular vesicles from conditioned media	63
Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years	63
The in vivo fate of polymeric micelles	63
Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms	63
Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy	62
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine	61
High-throughput proteomics and AI for cancer biomarker discovery	60
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across	60
Engineering interferons and interleukins for cancer immunotherapy	60
Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders	59
In situ activation of therapeutics through bioorthogonal catalysis	59
Cell-penetrating peptides in protein mimicry and cancer therapeutics	59
Nanomedicine for brain cancer	59
2D materials-based nanomedicine: From discovery to applications	58
α-Amino acid N-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery	58
Tumor-on-chip modeling of organ-specific cancer and metastasis	58
Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection	58
Tumor microenvironment-responsive dynamic inorganic nanoassemblies for cancer imaging and treatment	57
Clinical translation of advanced colonic drug delivery technologies	56
Advances in mRNA non-viral delivery approaches	56
Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants	56
Pharmaceutical applications of powder-based binder jet 3D printing process – A review	55
Metal-organic frameworks for therapeutic gas delivery	55
Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities	55
Smart gating porous particles as new carriers for drug delivery	55
Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models	54
Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals	54
Dry powder pharmaceutical biologics for inhalation therapy	53
Novel antimicrobial agents for combating antibiotic-resistant bacteria	53
In silico T cell epitope identification for SARS-CoV-2: Progress and perspectives	53
Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives	52
Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma	52
Advancing pharmacy and healthcare with virtual digital technologies	52
Defensins: The natural peptide antibiotic	52
Self-assembly of protein-polymer conjugates for drug delivery	52
Stabilizers and their interaction with formulation components in frozen and freeze-dried protein formulations	51
A quantitative view on multivalent nanomedicine targeting	51
Extracellular vesicles as antigen carriers for novel vaccination avenues	51
Electroactive material-based biosensors for detection and drug delivery	50
Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome	50
Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors	50
Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)	50
Autophagy in the cancer-immunity dialogue	49
Nucleic acid delivery with extracellular vesicles	49
Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach	49
Responsive optical probes for deep-tissue imaging: Photoacoustics and second near-infrared fluorescence	49
Synthetic multi-layer nanoparticles for CRISPR-Cas9 genome editing	48
Emerging strategies in developing multifunctional nanomaterials for cancer nanotheranostics	48
The promising interplay between sonodynamic therapy and nanomedicine	48
Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines	48
Nanotechnology-empowered vaccine delivery for enhancing CD8+ T cells-mediated cellular immunity	48
Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers	48
Engineering of stimuli-responsive self-assembled biomimetic nanoparticles	47
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders	47
Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting	47
Nanovaccines with cell-derived components for cancer immunotherapy	47
Bioinspired drug delivery strategies for repurposing conventional antibiotics against intracellular infections	47
Stability of lyophilized and spray dried vaccine formulations	47
Automation and data-driven design of polymer therapeutics	47
Listening to drug delivery and responses via photoacoustic imaging	47
Integration of personalized drug delivery systems into digital health	47
Stealth and pseudo-stealth nanocarriers	47
Modulating the foreign body response of implants for diabetes treatment	46
Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract	46
Advances and future perspectives in epithelial drug delivery	46
Extracellular vesicles as delivery systems at nano-/micro-scale	46
A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing	46

Nano-delivery to the lung - by inhalation or other routes and why nano when micro is largely sufficient?	46
Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches – An overview	45
Gene- and RNAi-activated scaffolds for bone tissue engineering: Current progress and future directions	45
Mastering the Gram-negative bacterial barrier – Chemical approaches to increase bacterial bioavailability of antibiotics	44
Development and aging of the lymphatic vascular system	44
Rationally designed drug delivery systems for the local treatment of resected glioblastoma	44
Microarray patches enable the development of skin-targeted vaccines against COVID-19	44
Decorated bacteria and the application in drug delivery	43
Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe	43
Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France”	43
GO-based antibacterial composites: Application and design strategies	43
Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages	43
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound	43
Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs	43
Two-Dimensional Nanomaterial-based catalytic Medicine: Theories, advanced catalyst and system design	42
Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopy	42
Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing	42
Formulation strategies to improve the efficacy of intestinal permeation enhancers,	42
Human skin equivalents: Impaired barrier function in relation to the lipid and protein properties of the stratum corneum	42
Ferritin nanocage: A promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier	41
The RNA-binding protein HuR in human cancer: A friend or foe?	41
Self-assembling peptides as vectors for local drug delivery and tissue engineering applications	41
Supercritical fluid (SCF)-assisted fabrication of carrier-free drugs: An eco-friendly welcome to active pharmaceutical ingredients (APIs)	40
In vitro and ex vivo models in inhalation biopharmaceutical research — advances, challenges and future perspectives	40
Delivering more for less: nanosized, minimal-carrier and pharmacoactive drug delivery systems	40
Bacterial membrane vesicles for vaccine applications	40
Artificial intelligence to bring nanomedicine to life	40
Antimicrobial blue light: A ‘Magic Bullet’ for the 21st century and beyond?	40
Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases	40
Nucleic acid nanoparticles (NANPs) as molecular tools to direct desirable and avoid undesirable immunological effects	39
Antifibrotic strategies for medical devices	39
Biomaterial-based delivery of nucleic acids for tissue regeneration	39
Extracellular vesicles for the treatment of central nervous system diseases	39
Adherence to minimal experimental requirements for defining extracellular vesicles and their functions	39
Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues	39
Organ-on-a-chip technology for the study of the female reproductive system	39
Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems	39
Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery	39
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy	38
Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments	38
The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis	38
Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy	38
Targeting the tumor biophysical microenvironment to reduce resistance to immunotherapy	38
Biomimetic immunomodulation strategies for effective tissue repair and restoration	38
Non-viral nanoparticles for RNA interference: Principles of design and practical guidelines	38
Sustained delivery approaches to improving adaptive immune responses	38
Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems	37
Drug release from in situ forming implants and advances in release testing	37
Role of extracellular vesicles in liver diseases and their therapeutic potential	37
Multifunctional plasmonic-magnetic nanoparticles for bioimaging and hyperthermia	37
Challenges and solutions in polymer drug delivery for bacterial biofilm treatment: A tissue-by-tissue account	37
Applications of focused ultrasound-mediated blood-brain barrier opening	37
Mucosal drug delivery and 3D printing technologies: A focus on special patient populations	37
Progress of engineered bacteria for tumor therapy	37
Engineering and loading therapeutic extracellular vesicles for clinical translation: A data reporting frame for comparability	37
Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models	37
Inhalation delivery technology for genome-editing of respiratory diseases	37
Particle engineering principles and technologies for pharmaceutical biologics	36
Dynamic nanoassemblies of nanomaterials for cancer photomedicine	36
Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges	36
Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches	36
Cell-based drug delivery systems and their in vivo fate	36
Polymers in pharmaceutical additive manufacturing: A balancing act between printability and product performance	36
Artificial intelligence and machine learning assisted drug delivery for effective treatment of infectious diseases	35
Nanotechnologies for the delivery of biologicals: Historical perspective and current landscape	35
Two-dimensional nanomaterials for tumor microenvironment modulation and anticancer therapy	35
Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment	35
Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors	35
Mechanisms of immune response to inorganic nanoparticles and their degradation products	35
Versatility on demand – The case for semi-solid micro-extrusion in pharmaceutics	35
Merging data curation and machine learning to improve nanomedicines	35
Highly branched poly(β-amino ester)s for gene delivery in hereditary skin diseases	35
Can microorganisms develop resistance against light based anti-infective agents?	35
Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing	35
Coiled coil-based therapeutics and drug delivery systems	35
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment	34
Medical devices, smart drug delivery, wearables and technology for the treatment of Diabetes Mellitus	34
Recent advances in long-acting drug delivery systems for anticancer drug	34
Controlling drug release with additive manufacturing-based solutions	34
Drug delivery carriers with therapeutic functions	34
Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics	34
Oral lipid nanomedicines: Current status and future perspectives in cancer treatment	34
Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems	34
Activatable fluorescent probes for real-time imaging-guided tumor therapy	34
Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?	33
Opportunities and delusions regarding drug delivery targeting pancreatic cancer-associated fibroblasts	33
Non-viral strategies for delivering genome editing enzymes	33
Jet injectors: Perspectives for small volume delivery with lasers	33
Nanoparticle entry into cells; the cell biology weak link	33
Emerging targeted drug delivery strategies toward ovarian cancer	33
Destruction of tumor vasculature by vascular disrupting agents in overcoming the limitation of EPR effect	33
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation	32
Current understandings and clinical translation of nanomedicines for breast cancer therapy	32
Pharmaceutical protein solids: Drying technology, solid-state characterization and stability	32
Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies	32