Advanced Drug Delivery Reviews

Article	Citations
Editorial board members	1059
Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies	388
Recent advances in endocrine organoids for therapeutic application	317
Gene editing strategies to treat lysosomal disorders: The example of mucopolysaccharidoses	291
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles	258
Advances in lung-on-a-chip platforms for nanotherapeutic evaluation and screening	254
Protein-based nanocarriers in the management of hard-to-treat solid tumours	248
Bacterially mediated drug delivery and therapeutics: Strategies and advancements	237
Cell membrane-coated nanoparticles for targeting carcinogenic bacteria	229
Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond	221
Covalent chemistry in targeted protein degradation	210
On-Chip modeling of drug-gut interactions in Oral drug delivery	210
Liposomal formulations for treating lysosomal storage disorders	207
Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art	206
Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound	194
Nanoparticle-neutrophils interactions for autoimmune regulation	190
MIDD in Japan– Implementations, challenges and opportunities	188
Penetration and translocation of functional inorganic nanomaterials into biological barriers	187
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine	176
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders	174
Models to study basic and applied aspects of lysosomal storage disorders	171
In vitro models of the interplay between glioblastoma and blood–brain barrier for stratifying drug efficacy	170
Genome-scale metabolic modelling in antimicrobial pharmacology: Present and future	164
Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity	157
Long-acting inhaled medicines: Present and future	154

Editorial Board	152
Editorial Board	151
Emerging Voices in Drug Delivery – Harnessing and Modulating Complex Biological Systems (Issue 2)	147
Targeting microbiome, drug metabolism, and drug delivery in oncology	147
iPSC-derived T cells and macrophages: Manufacturing and next-generation application approaches	145
Red to near-infrared carbon dots: synthesis, cellular interactions, drug loading, and therapeutic applications	145
Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics	144
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease	143
Activatable dual-functional molecular agents for imaging-guided cancer therapy	142
Synthetic biology-guided design and biosynthesis of protein polymers for delivery	135
Activatable fluorescent probes for real-time imaging-guided tumor therapy	132
Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications	128
3D printing of drug delivery systems enhanced with micro/nano-technology	124
Quality by Computational Design: Harnessing AI to Advance Rational Drug Development	124
Exosome- and extracellular vesicle-based approaches for the treatment of lysosomal storage disorders	123
In situ cellular hitchhiking of nanoparticles for drug delivery	122
From molecule to absorption: a multiscale framework for subcutaneous biologic delivery	121
Novel strategies for modulating the gut microbiome for cancer therapy	120
From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly	119
Solid implantable devices for sustained drug delivery	119
Small data, big challenges: Machine- and deep-learning strategies for data-limited drug discovery	118
Drug delivery using gold nanoparticles	116
Biopharmaceutical drug delivery and phototherapy using protein crystals	115
Strategies to develop polymeric microneedles for controlled drug release	115
RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer	115
Convection-enhanced delivery for brain malignancies: Technical parameters, formulation strategies and clinical perspectives	113
Hydrogen sulfide in cancer therapy: Intelligent delivery platforms and synergistic therapeutic paradigms	113
Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies	112
Novel drug delivery systems for the management of dry eye	111
Matrix-integrated microfluidic tumor models for evaluating drug delivery systems and pre-clinical testing	107
Nanobodies: Robust miniprotein binders in biomedicine	105
Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases	105
Lysosomal therapies and drug delivery strategies: An overview	105
Hurdles in translating science from lab to market in delivery systems for Cosmetics: An industrial perspective	104
Advances in photoactivated carbon-based nanostructured materials for targeted cancer therapy	99
Soft nano and microstructures for the photomodulation of cellular signaling and behavior	99
Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos	98
Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers	98
Technology for Nucleic Acid Delivery in the Treatment of Hematological Malignancies	98
Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: New avenues for personalized therapeutic strategies	98
Therapeutic gases as emerging treatments for oral diseases	98
Unignored intracellular journey and biomedical applications of extracellular vesicles	97
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system	97
Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors	97
Fit and forget: The future of dental implant therapy via nanotechnology	96
Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers	95
Tumour extravasation of nanomedicine: The EPR and alternative pathways	95
Model-informed precision dosing: State of the art and future perspectives	94
Preface: Image-assisted organoid research and application	94
Harnessing reactive oxygen species for precision medicine: ROS-Activatable PROTACs for lung Cancer	93

Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328]	93
Editorial Board	92
Editorial Board	90
Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications	89
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease	89
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration	88
Engineering tissue patterning in human stem cell-based embryo models	88
Microfluidic reactors for the synthesis of inorganic and hybrid nanoparticles for drug delivery	87
Design of disintegrable nanoassemblies to release multiple small-sized nanoparticles	87
Nanoparticle-based immunotherapeutics: From the properties of nanocores to the differential effects of administration routes	86
Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy	85
Recent progress in upconversion nanomaterials for emerging optical biological applications	85
Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory	84
Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers	84
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders	84
Design principles for construction of DNA-based nanostructures	83
Aptamer-based targeted drug delivery and disease therapy in preclinical and clinical applications	83
Rational modification of PROTACs for tumor-selective protein degradation	83
Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment	82
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy	81
Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness	80
Additive manufacturing in spatial patterning for spinal cord injury treatment	79
Recent advances in intelligent oxygen delivery systems for tissue regeneration	79
Microbial heterogeneity-mediated treatment evasion and the potential for engineered live biotherapeutic products	78
Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery	77
Omics approaches for the assessment of biological responses to nanoparticles	77
From implantable to wearable: recent advances in microfluidic platforms for precision drug delivery	77
Medicinal gases for treating central nervous system injuries	76
Spectral computed tomography with inorganic nanomaterials: State-of-the-art	75
Patient-Derived 3D-Bioprinted Models of Pancreatic Cancer: Toward Personalized Therapy and Overcoming Tumor Microenvironment Challenges	75
Integrating PROTAC-based targeted protein degradation with nanodelivery systems to overcome cancer therapeutic resistance	75
Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models	74
Drug delivery, development, and technological aspects for peripheral drug eluting stents	74
Investigating the restriction-modification barrier to DNA delivery in human gut probiotic bacteria for streamlined genetic tool development	73
From canes to pills: the evolution of carbon monoxide therapeutics	72
mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond	72
Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo	71
Editorial Board	71
Corrigendum to “Advanced theragnostics for the central nervous system (CNS) and neurological disorders using functional inorganic nanomaterials” [Adv. Drug Delivery Rev. 192 (2023) 114636]	70
Editorial Board	69
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook	68
Applications of pharmacometrics in drug development	68
Steric stabilization of bioactive nanoparticles using elastin-like polypeptides	68
Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics	67
Nanoscale metal-organic frameworks regulate redox homeostasis for Cancer therapy	67
Nitric oxide-modulating biomaterials for therapeutic Immunoengineering	67
Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome	66
Stimuli-activatable protein degraders for targeted cancer therapy: from prodrug design to nanoplatform applications	66
Imaging drug delivery to the lungs: Methods and applications in oncology	66
Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery	66
High-Dose Subcutaneous Administration of Biologics: Overcoming Barriers Through Formulation and Device Innovation	65
Recent developments in lactose blend formulations for carrier-based dry powder inhalation	65
3D extrusion bioprinting of microbial inks for biomedical applications	64
Polymer-based nanomedicines: Supporting multimodal approaches to glioblastoma multiforme treatment	64
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives	64
Editorial board members	63
Corrigendum to “Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic” [Adv. Drug Delivery Rev. 179 (2021) 114000]	63
Corrigendum to “Light sheet fluorescence microscopy for monitoring drug delivery: unlocking the developmental phases of embryos” [Adv Drug Del. Rev. 218 (2025) 115520]	63
Microbubble-assisted ultrasound for inner ear drug delivery	62
Ocular therapies with biomacromolecules: From local injection to eyedrop and emerging noninvasive delivery strategies	62
Self-assembled Nano-PROTACs: bridging chemical design and biological barriers in targeted protein degradation	62
Revealing the clinical potential of high-resolution organoids	62
Pancreatic organoids as cancer avatars for true personalized medicine	61
Progress of tumor-resident intracellular bacteria for cancer therapy	61
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics	60
Biosafety of mesoporous silica nanoparticles; towards clinical translation	60
Sustained delivery approaches to improving adaptive immune responses	59
Towards artificial intelligence-enabled extracellular vesicle precision drug delivery	58
Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment	58
Nanomedicine for targeting brain Neurodegeneration: Critical barriers and circadian rhythm Considerations	58
Next generation concepts in dermal delivery, theranostics, and preclinical testing	57
Editorial Board	57
Editorial board members	56
Editorial Board	56
Editorial board members	55
Editorial board members	55
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer	55
Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS	55
Cell-based relay delivery strategy in biomedical applications	55
Synergies between data science methods and innovative drug delivery technologies	54

Theme issue: In vitro mucus models	54
Current issues in optical monitoring of drug delivery via hair follicles	53
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria	53
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling	52
Intranasal drug delivery to the brain for neurodegenerative diseases: Current efforts and challenges in delivery platforms and modeling	52
Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future perspectives	52
Advanced oral therapies for colorectal cancer via nanomedicine and microbiota modulation	52
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems	52
Advances in modular control of CAR-T therapy with adapter-mediated CARs	52
Photonic and magnetic materials for on-demand local drug delivery	51
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics	51
Long-acting parenteral drug delivery systems for the treatment of chronic diseases	51
Precise subcellular targeting approaches for organelle-related disorders	51
Stealth and pseudo-stealth nanocarriers	51
Transdermal drug delivery via microneedles to mediate wound microenvironment	51
Fungal infections: Immune defense, immunotherapies and vaccines	50
Recent applications of three-dimensional bioprinting in drug discovery and development	50
Microbiome as an immune regulator in health, disease, and therapeutics	50
Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor	50
Emerging techniques for modeling and simulating subcutaneous injection and fate of drugs after injection	50
Characterization of dry powder inhaler performance through experimental methods	49
Editorial Board	49
Interaction of 2D nanomaterial with cellular barrier: Membrane attachment and intracellular trafficking	49
Advances in mRNA therapeutics for cancer immunotherapy: From modification to delivery	48
Editorial Board	48
Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap	48
Redox responsive nanosystems for medicine: from reactive species mapping to precision treatment	48
Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery	48
Polymeric in situ forming depots for long-acting drug delivery systems	47
Interference of layered double hydroxide nanoparticles with pathways for biomedical applications	47
Overcoming barriers and shaping the future: Challenges and innovations in nucleic acid therapies for Glioblastoma	46
Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease	46
Advanced delivery systems for peptide antibiotics	46
Effects of nanoparticle deformability on multiscale biotransport	46
Novel antimicrobial agents for combating antibiotic-resistant bacteria	46
Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies	46
3D printing of pharmaceutical dosage forms: Recent advances and applications	45
Bioengineering toolkits for potentiating organoid therapeutics	45
Editorial board members	44
Cytokine conjugates to elastin-like polypeptides	44
Gene editing therapeutics based on mRNA delivery	44
The complex and intricate relationship between incremental science, innovation and recognition	43
Editorial board members	43
Target- and prodrug-based design for fungal diseases and cancer-associated fungal infections	43
Emerging translational approaches for brain cancer therapeutics	43
Functional antibody delivery: Advances in cellular manipulation	42
Encapsulation and immune protection for type 1 diabetes cell therapy	42
Near-infrared fluorescence imaging-guided targeted drug delivery in gastric tumors: From molecular design to clinical translation	42
Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine	42
Opportunities for artificial intelligence and synthetic biology in designing living drug delivery systems	42
DectiSomes: C-type lectin receptor-targeted liposomes as pan-antifungal drugs	41
Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics	41
Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research	41
Engineering nanosystems to overcome barriers to cancer diagnosis and treatment	41
The spatiotemporal journey of nanomedicines in solid tumors on their therapeutic efficacy	40
Nitric oxide releasing graphene for next-generation therapeutics	40
Nanoscale contrast agents: A promising tool for ultrasound imaging and therapy	40
Editorial board members	40
Extracellular vesicles for improved tumor accumulation and penetration	40
Advances in local drug delivery technologies for improved rheumatoid arthritis therapy	40
Biologics-device combinations: Enabling prolonged therapies in the posterior segment ocular disease	39
Guiding design and performance of nonviral nucleic acid delivery vehicles via machine learning	39
Extracellular vesicles over adeno-associated viruses: Advantages and limitations as drug delivery platforms in precision medicine	39
Crossing borders in Alzheimer’s disease: A T cell’s perspective	39
Advanced optical imaging for the rational design of nanomedicines	39
Editorial Board	39
Implantable systems for neurological chronotherapy	39
Recent advances in 3D bioprinted neural models: A systematic review on the applications to drug discovery	39
siRNA drug delivery across the blood–brain barrier in Alzheimer's disease	38
Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery	38
Perspectives and trends in gas delivery systems based on ultrasound responsive nanomaterials for cancer therapy	38
Engineering in vivo behavior of DNA nanostructures toward organ-targeted drug delivery	38
Editorial Board	38
A review of upper airway physiology relevant to the delivery and deposition of inhalation aerosols	37
PhotoChem Interplays: Lighting the Way for Drug Delivery and Diagnosis	37
Biophysical heterogeneity of myeloid-derived microenvironment to regulate resistance to cancer immunotherapy	37
Editorial Board	37
Fluorescence microscopic platforms imaging mitochondrial abnormalities in neurodegenerative diseases	37
Cell-based drug delivery systems and their in vivo fate	36
Emerging opportunities in bioconjugates of Elastin-like polypeptides with synthetic or natural polymers	35
Treating allergies via skin – Recent advances in cutaneous allergen immunotherapy	35
Paving the way for bacteria-based drug delivery: biohybrid microrobots emerging from microrobotics and synthetic biology	35
The role of CCL2/CCR2 axis in cancer and inflammation: The next frontier in nanomedicine	35
Recent developments in the computational simulation of dry powder inhalers	35
Droplet-based 3D bioprinting for drug delivery and screening	35
Caenorhabditis elegans as an emerging high throughput chronotherapeutic drug screening platform for human neurodegenerative disorders	35
The role of imaging in targeted delivery of nanomedicine for cancer therapy	34
Implications of genetic and epigenetic aberrations to the tumorigenicity of human pluripotent stem cells	34
Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy	34
Programmability and biomedical utility of intrinsically-disordered protein polymers	34
Engineering the right formulation for enhanced drug delivery	34
Nano-based eye drop: Topical and noninvasive therapy for ocular diseases	33
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment	33
Editorial Board	33
Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin	33