Advanced Drug Delivery Reviews

Article	Citations
Drug delivery strategies in maximizing anti-angiogenesis and anti-tumor immunity	576
Leveraging the neurosurgical operating room for therapeutic development in NeuroOncology	557
Drug delivery for metabolism targeted cancer immunotherapy	333
Editorial board members	262
Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies	254
Models to study basic and applied aspects of lysosomal storage disorders	250
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine	249
Recent advances in endocrine organoids for therapeutic application	247
MIDD in Japan– Implementations, challenges and opportunities	246
Bacterially mediated drug delivery and therapeutics: Strategies and advancements	223
Tools for computational design and high-throughput screening of therapeutic enzymes	220
Agony of choice: How anesthetics affect the composition and function of extracellular vesicles	207
Gene editing strategies to treat lysosomal disorders: The example of mucopolysaccharidoses	206
Long-acting inhaled medicines: Present and future	205
Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound	204
Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics	195
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles	183
Liposomal formulations for treating lysosomal storage disorders	178
Nanoparticle-neutrophils interactions for autoimmune regulation	172
Therapeutic and delivery strategies of phytoconstituents for renal fibrosis	171
Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art	170
Nanovaccines with cell-derived components for cancer immunotherapy	167
Penetration and translocation of functional inorganic nanomaterials into biological barriers	161
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders	157
Deciphering albumin-directed drug delivery by imaging	155

Cell membrane-coated nanoparticles for targeting carcinogenic bacteria	153
Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond	147
MicroRNAs and their delivery in diabetic fibrosis	142
Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies	142
Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity	137
Biopharmaceutical drug delivery and phototherapy using protein crystals	136
Emerging Voices in Drug Delivery – Harnessing and Modulating Complex Biological Systems (Issue 2)	135
Editorial/Preface	135
Ultrasonic particles: An approach for targeted gene delivery	132
In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols	132
Targeting microbiome, drug metabolism, and drug delivery in oncology	129
Editorial Board	128
Activatable dual-functional molecular agents for imaging-guided cancer therapy	125
Lipid nanoparticle formulations for targeting leukocytes with therapeutic RNA in liver fibrosis	125
Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics	124
Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications	123
RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer	121
Separation, characterization, and standardization of extracellular vesicles for drug delivery applications	120
Physical methods for enhancing drug absorption from the gastrointestinal tract	119
Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery	118
In situ cellular hitchhiking of nanoparticles for drug delivery	117
Exosome- and extracellular vesicle-based approaches for the treatment of lysosomal storage disorders	117
Strategies to develop polymeric microneedles for controlled drug release	116
Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases	115
Synthetic biology-guided design and biosynthesis of protein polymers for delivery	114
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease	112
3D printing of drug delivery systems enhanced with micro/nano-technology	111
From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly	110
Role of extracellular vesicles in liver diseases and their therapeutic potential	108
Novel strategies for modulating the gut microbiome for cancer therapy	106
Phytonanomaterials as therapeutic agents and drug delivery carriers	105
Drug delivery using gold nanoparticles	105
Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches	105
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers	105
Activatable fluorescent probes for real-time imaging-guided tumor therapy	104
Solid implantable devices for sustained drug delivery	104
Engineering complexity in human tissue models of cancer	104
Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems	104
Lysosomal therapies and drug delivery strategies: An overview	104
Micro-patterned cell populations as advanced pharmaceutical drugs with precise functional control	103
Soft nano and microstructures for the photomodulation of cellular signaling and behavior	103
Technological and translational challenges for extracellular vesicle in therapy and diagnosis	103
Tumour extravasation of nanomedicine: The EPR and alternative pathways	100
Modular design principle based on compartmental drug delivery systems	99
In-vitro 3D modelling for charged particle therapy – Uncertainties and opportunities	99
Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors	98
Unignored intracellular journey and biomedical applications of extracellular vesicles	97
Vaginal drug delivery approaches for localized management of cervical cancer	97
Nanobodies: Robust miniprotein binders in biomedicine	97
High-throughput proteomics and AI for cancer biomarker discovery	96

The extracellular matrix of hematopoietic stem cell niches	96
Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases	96
Fit and forget: The future of dental implant therapy via nanotechnology	95
Recent trends in drug-delivery systems for the treatment of diabetic retinopathy and associated fibrosis	95
Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer	95
Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos	95
Drug delivery strategies for management of women’s health issues in the upper genital tract	95
Model-informed precision dosing: State of the art and future perspectives	94
To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives	93
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system	93
Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers	92
Editorial board members	92
Hurdles in translating science from lab to market in delivery systems for Cosmetics: An industrial perspective	92
Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities	92
Novel drug delivery systems for the management of dry eye	92
Editorial board members	91
Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328]	90
Editorial board members	90
Corrigendum to ‘Cell-penetrating peptides in protein mimicry and cancer therapeutics’ [Advanced Drug Delivery Reviews, 180 (2022), 114044]	88
Modulating tumor physical microenvironment for fueling CAR-T cell therapy	87
Responsive nanomedicines enhanced by or enhancing physical modalities to treat solid cancer tumors: Preclinical and clinical evidence of safety and efficacy	87
Preface: Image-assisted organoid research and application	87
Recent progress in upconversion nanomaterials for emerging optical biological applications	86
Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery	86
Engineering and loading therapeutic extracellular vesicles for clinical translation: A data reporting frame for comparability	84
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease	84
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration	83
Implications and pitfalls for cancer diagnostics exploiting extracellular vesicles	83
Women-specific routes of administration for drugs: A critical overview	82
Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment	81
Nanomedicine from amphiphilized prodrugs: Concept and clinical translation	81
Listening to drug delivery and responses via photoacoustic imaging	81
Design of disintegrable nanoassemblies to release multiple small-sized nanoparticles	80
Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory	80
Nanoparticles for local delivery of siRNA in lung therapy	80
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy	80
Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy	79
Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers	79
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders	79
Nanoparticle-based immunotherapeutics: From the properties of nanocores to the differential effects of administration routes	79
Dynamic nanoassembly-based drug delivery system (DNDDS): Learning from nature	78
Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)	78
Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness	77
Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models	77
Additive manufacturing in spatial patterning for spinal cord injury treatment	76
Can microorganisms develop resistance against light based anti-infective agents?	76
Biophotonics for diagnostic detection of extracellular vesicles	75
Targeting fibrosis in the failing heart with nanoparticles	75
The role of sex as a biological variable in the efficacy and toxicity of therapeutic nanomedicine	75
Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19	75
Blood-brain barrier delivery for lysosomal storage disorders with IgG-lysosomal enzyme fusion proteins	75
Spectral computed tomography with inorganic nanomaterials: State-of-the-art	75
Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery	73
Clinical translation of advanced colonic drug delivery technologies	73
Omics approaches for the assessment of biological responses to nanoparticles	71
Progress of engineered bacteria for tumor therapy	71
3D extrusion bioprinting of microbial inks for biomedical applications	71
mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond	71
Corrigendum to “Advanced theragnostics for the central nervous system (CNS) and neurological disorders using functional inorganic nanomaterials” [Adv. Drug Delivery Rev. 192 (2023) 114636]	70
Synthetic polypeptides for drug and gene delivery, and tissue engineering	70
Editorial Board	70
Applications of pharmacometrics in drug development	70
Of devices and drugs – Ingestible bots for diagnosis and therapy	69
Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics	69
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook	69
Imaging drug delivery to the lungs: Methods and applications in oncology	69
Dynamic nano-assemblies based on two-dimensional inorganic nanoparticles: Construction and preclinical demonstration	69
Cell-penetrating peptides in protein mimicry and cancer therapeutics	68
Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics	68
Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo	68
Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy	68
Intrathecal delivery and its applications in leptomeningeal disease	68
The dynamic, motile and deformative properties of RNA nanoparticles facilitate the third milestone of drug development	67
Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery	67
Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome	67
Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance	66
Engineering stromal heterogeneity in cancer	66
Steric stabilization of bioactive nanoparticles using elastin-like polypeptides	66
Local scaffold-assisted delivery of immunotherapeutic agents for improved cancer immunotherapy	65
Engineering of stimuli-responsive self-assembled biomimetic nanoparticles	65

Nanoarchitectured two-dimensional layered double hydroxides-based nanocomposites for biomedical applications	65
Adherence to minimal experimental requirements for defining extracellular vesicles and their functions	65
Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment	65
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound	65
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives	64
Recent developments in lactose blend formulations for carrier-based dry powder inhalation	63
Special Issue (SI) on: Emerging pharmaceutical technologies (From advanced materials & formulations to new processes) for novel dosage development	63
Editorial board members	63
Corrigendum to “Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic” [Adv. Drug Delivery Rev. 179 (2021) 114000]	62
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics	62
Merging data curation and machine learning to improve nanomedicines	62
The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery	62
Extracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds – A perspective	62
Progress of tumor-resident intracellular bacteria for cancer therapy	62
Revealing the clinical potential of high-resolution organoids	61
The tendon microenvironment: Engineered in vitro models to study cellular crosstalk	61
Corrigendum to “Light sheet fluorescence microscopy for monitoring drug delivery: unlocking the developmental phases of embryos” [Adv Drug Del. Rev. 218 (2025) 115520]	61
Delivery of synthetic mRNAs for tissue regeneration	61
Biosafety of mesoporous silica nanoparticles; towards clinical translation	60
Ocular therapies with biomacromolecules: From local injection to eyedrop and emerging noninvasive delivery strategies	60
Sustained delivery approaches to improving adaptive immune responses	60
Towards artificial intelligence-enabled extracellular vesicle precision drug delivery	60
Microneedle-Mediated Vaccination: Innovation and Translation	60
Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe	60
Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors – An update	59
Smart gating porous particles as new carriers for drug delivery	59
Microbubble-assisted ultrasound for inner ear drug delivery	59
Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years	58
Biomaterial-based delivery of nucleic acids for tissue regeneration	58
Laser ablation: Heating up the anti-tumor response in the intracranial compartment	58
Advances in solid formulation of pharmaceutical biologics	58
Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment	58
Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms	58
Editorial board members	57
Editorial board members	57
Editorial board members	57
Editorial board members	57
Editorial board members	57
Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future perspectives	57
Next generation concepts in dermal delivery, theranostics, and preclinical testing	56
Long-acting parenteral drug delivery systems for the treatment of chronic diseases	56
Editorial Board	56
Drugging the lymphatic system: An emerging opportunity for cancer immunotherapy	56
Advances in long-acting injectables, implants, and vaginal rings for contraception and HIV prevention	56
Editorial Board	56
Theme issue: In vitro mucus models	56
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health	55
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics	55
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation	55
Cellular protein markers, therapeutics, and drug delivery strategies in the treatment of diabetes-associated liver fibrosis	55
Synthetic RNA-based post-transcriptional expression control methods and genetic circuits	55
Advances in modular control of CAR-T therapy with adapter-mediated CARs	54
Photonic and magnetic materials for on-demand local drug delivery	54
Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles	54
Current issues in optical monitoring of drug delivery via hair follicles	54
The role of the HBCU pipeline in diversifying the STEM workforce: Training the next generation of drug delivery researchers	53
Cell-based relay delivery strategy in biomedical applications	53
Fungal infections: Immune defense, immunotherapies and vaccines	53
Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic	53
Biomedical engineering of two-dimensional MXenes	52
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer	52
Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS	52
Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment	52
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems	52
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria	52
The past, present, and future of breast cancer models for nanomedicine development	52
Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening	52
Leveraging advances in immunopathology and artificial intelligence to analyze in vitro tumor models in composition and space	52
Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor	51
Mesoporous silica nanoparticles for pulmonary drug delivery	51
Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids	51
Transdermal drug delivery via microneedles to mediate wound microenvironment	51
Stealth and pseudo-stealth nanocarriers	51
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling	51
The RNA-binding protein HuR in human cancer: A friend or foe?	51
Gene editing therapeutics based on mRNA delivery	50
Imaging and therapeutic targeting of the tumor immune microenvironment with biologics	50
Recent applications of three-dimensional bioprinting in drug discovery and development	50
Effects of nanoparticle deformability on multiscale biotransport	50
Precise subcellular targeting approaches for organelle-related disorders	50
Editorial Board	50
The effects of protein corona on in vivo fate of nanocarriers	50
Bioengineering toolkits for potentiating organoid therapeutics	49
Interaction of 2D nanomaterial with cellular barrier: Membrane attachment and intracellular trafficking	49
Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap	49
Characterization of dry powder inhaler performance through experimental methods	49
3D printing of pharmaceutical dosage forms: Recent advances and applications	49
Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery	48
Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease	48
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine	48
Translating a radiolabeled imaging agent to the clinic	48
Polymeric in situ forming depots for long-acting drug delivery systems	47
Microbiome as an immune regulator in health, disease, and therapeutics	47
Advances in mRNA therapeutics for cancer immunotherapy: From modification to delivery	47
Materials and device design for advanced phototherapy systems	47