Advanced Drug Delivery Reviews

Article	Citations
Gene editing strategies to treat lysosomal disorders: The example of mucopolysaccharidoses	825
Editorial board members	413
Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies	330
Genome-scale metabolic modelling in antimicrobial pharmacology: Present and future	327
MicroRNAs and their delivery in diabetic fibrosis	297
Tools for computational design and high-throughput screening of therapeutic enzymes	293
MIDD in Japan– Implementations, challenges and opportunities	267
Leveraging the neurosurgical operating room for therapeutic development in NeuroOncology	227
Penetration and translocation of functional inorganic nanomaterials into biological barriers	220
Drug delivery for metabolism targeted cancer immunotherapy	213
Liposomal formulations for treating lysosomal storage disorders	194
In vitro models of the interplay between glioblastoma and blood–brain barrier for stratifying drug efficacy	193
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles	192
Recent advances in endocrine organoids for therapeutic application	180
Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond	176
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders	170
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine	166
Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound	165
Long-acting inhaled medicines: Present and future	165
Bacterially mediated drug delivery and therapeutics: Strategies and advancements	159
Nanoparticle-neutrophils interactions for autoimmune regulation	158
Nanovaccines with cell-derived components for cancer immunotherapy	153
Models to study basic and applied aspects of lysosomal storage disorders	149
Deciphering albumin-directed drug delivery by imaging	148
Cell membrane-coated nanoparticles for targeting carcinogenic bacteria	144

Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art	144
Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity	143
Editorial Board	134
Editorial/Preface	133
Targeting microbiome, drug metabolism, and drug delivery in oncology	132
Hydrogen sulfide in cancer therapy: Intelligent delivery platforms and synergistic therapeutic paradigms	130
Emerging Voices in Drug Delivery – Harnessing and Modulating Complex Biological Systems (Issue 2)	130
Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications	128
Biopharmaceutical drug delivery and phototherapy using protein crystals	123
Red to near-infrared carbon dots: synthesis, cellular interactions, drug loading, and therapeutic applications	121
Activatable dual-functional molecular agents for imaging-guided cancer therapy	121
Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics	120
Synthetic biology-guided design and biosynthesis of protein polymers for delivery	118
iPSC-derived T cells and macrophages: Manufacturing and next-generation application approaches	117
3D printing of drug delivery systems enhanced with micro/nano-technology	116
Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches	115
Novel strategies for modulating the gut microbiome for cancer therapy	113
Activatable fluorescent probes for real-time imaging-guided tumor therapy	113
In situ cellular hitchhiking of nanoparticles for drug delivery	112
From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly	111
Exosome- and extracellular vesicle-based approaches for the treatment of lysosomal storage disorders	107
Solid implantable devices for sustained drug delivery	106
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease	104
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers	104
Strategies to develop polymeric microneedles for controlled drug release	103
RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer	103
Hurdles in translating science from lab to market in delivery systems for Cosmetics: An industrial perspective	102
Drug delivery using gold nanoparticles	102
Micro-patterned cell populations as advanced pharmaceutical drugs with precise functional control	101
Lysosomal therapies and drug delivery strategies: An overview	101
Convection-enhanced delivery for brain malignancies: Technical parameters, formulation strategies and clinical perspectives	99
Soft nano and microstructures for the photomodulation of cellular signaling and behavior	97
Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies	96
Fit and forget: The future of dental implant therapy via nanotechnology	95
The extracellular matrix of hematopoietic stem cell niches	95
Tumour extravasation of nanomedicine: The EPR and alternative pathways	94
Unignored intracellular journey and biomedical applications of extracellular vesicles	94
Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers	93
Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases	93
Model-informed precision dosing: State of the art and future perspectives	93
Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: New avenues for personalized therapeutic strategies	92
Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers	92
Engineering complexity in human tissue models of cancer	91
Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer	90
Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors	88
Novel drug delivery systems for the management of dry eye	88
Advances in photoactivated carbon-based nanostructured materials for targeted cancer therapy	88
To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives	88
Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos	88
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system	88

Nanobodies: Robust miniprotein binders in biomedicine	87
Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328]	86
Preface: Image-assisted organoid research and application	86
Editorial board members	85
Corrigendum to ‘Cell-penetrating peptides in protein mimicry and cancer therapeutics’ [Advanced Drug Delivery Reviews, 180 (2022), 114044]	85
Editorial Board	85
Editorial board members	85
Responsive nanomedicines enhanced by or enhancing physical modalities to treat solid cancer tumors: Preclinical and clinical evidence of safety and efficacy	84
Design principles for construction of DNA-based nanostructures	84
Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery	84
Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment	83
Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease	83
Editorial Board	81
Modulating tumor physical microenvironment for fueling CAR-T cell therapy	80
Nanoparticle-based immunotherapeutics: From the properties of nanocores to the differential effects of administration routes	80
Aptamer-based targeted drug delivery and disease therapy in preclinical and clinical applications	80
Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy	80
Listening to drug delivery and responses via photoacoustic imaging	80
Design of disintegrable nanoassemblies to release multiple small-sized nanoparticles	79
Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers	79
Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications	79
Recent progress in upconversion nanomaterials for emerging optical biological applications	78
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders	78
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration	78
Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models	77
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy	77
Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness	77
Recent advances in intelligent oxygen delivery systems for tissue regeneration	77
Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory	77
Patient-Derived 3D-Bioprinted Models of Pancreatic Cancer: Toward Personalized Therapy and Overcoming Tumor Microenvironment Challenges	76
Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery	76
Drug delivery, development, and technological aspects for peripheral drug eluting stents	76
Investigating the restriction-modification barrier to DNA delivery in human gut probiotic bacteria for streamlined genetic tool development	74
Omics approaches for the assessment of biological responses to nanoparticles	74
Blood-brain barrier delivery for lysosomal storage disorders with IgG-lysosomal enzyme fusion proteins	73
mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond	72
Progress of engineered bacteria for tumor therapy	72
Spectral computed tomography with inorganic nanomaterials: State-of-the-art	71
Additive manufacturing in spatial patterning for spinal cord injury treatment	71
Clinical translation of advanced colonic drug delivery technologies	70
Intrathecal delivery and its applications in leptomeningeal disease	70
Editorial Board	70
Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo	69
Corrigendum to “Advanced theragnostics for the central nervous system (CNS) and neurological disorders using functional inorganic nanomaterials” [Adv. Drug Delivery Rev. 192 (2023) 114636]	69
Of devices and drugs – Ingestible bots for diagnosis and therapy	69
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook	68
Dynamic nano-assemblies based on two-dimensional inorganic nanoparticles: Construction and preclinical demonstration	68
Applications of pharmacometrics in drug development	68
Steric stabilization of bioactive nanoparticles using elastin-like polypeptides	67
The dynamic, motile and deformative properties of RNA nanoparticles facilitate the third milestone of drug development	66
Polymer-based nanomedicines: Supporting multimodal approaches to glioblastoma multiforme treatment	66
Cell-penetrating peptides in protein mimicry and cancer therapeutics	66
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound	66
Imaging drug delivery to the lungs: Methods and applications in oncology	65
3D extrusion bioprinting of microbial inks for biomedical applications	65
Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome	64
Local scaffold-assisted delivery of immunotherapeutic agents for improved cancer immunotherapy	63
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives	63
Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery	63
Nitric oxide-modulating biomaterials for therapeutic Immunoengineering	63
Recent developments in lactose blend formulations for carrier-based dry powder inhalation	62
Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy	62
Ocular therapies with biomacromolecules: From local injection to eyedrop and emerging noninvasive delivery strategies	61
Nanoarchitectured two-dimensional layered double hydroxides-based nanocomposites for biomedical applications	61
Microbubble-assisted ultrasound for inner ear drug delivery	61
Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics	61
Pancreatic organoids as cancer avatars for true personalized medicine	60
Nanomedicine for targeting brain Neurodegeneration: Critical barriers and circadian rhythm Considerations	60
The tendon microenvironment: Engineered in vitro models to study cellular crosstalk	59
Editorial board members	59
Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors – An update	58
Progress of tumor-resident intracellular bacteria for cancer therapy	58
Corrigendum to “Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic” [Adv. Drug Delivery Rev. 179 (2021) 114000]	58
Revealing the clinical potential of high-resolution organoids	58
Special Issue (SI) on: Emerging pharmaceutical technologies (From advanced materials & formulations to new processes) for novel dosage development	58
Sustained delivery approaches to improving adaptive immune responses	57
Corrigendum to “Light sheet fluorescence microscopy for monitoring drug delivery: unlocking the developmental phases of embryos” [Adv Drug Del. Rev. 218 (2025) 115520]	57
Laser ablation: Heating up the anti-tumor response in the intracranial compartment	57
Biosafety of mesoporous silica nanoparticles; towards clinical translation	56
Towards artificial intelligence-enabled extracellular vesicle precision drug delivery	56

Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics	56
Merging data curation and machine learning to improve nanomedicines	56
Next generation concepts in dermal delivery, theranostics, and preclinical testing	55
Editorial Board	55
Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future perspectives	55
Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment	55
Editorial Board	55
Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS	54
Theme issue: In vitro mucus models	54
Editorial board members	54
Editorial board members	54
Editorial board members	54
Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic	53
Current issues in optical monitoring of drug delivery via hair follicles	53
Synthetic RNA-based post-transcriptional expression control methods and genetic circuits	53
Drugging the lymphatic system: An emerging opportunity for cancer immunotherapy	53
Cell-based relay delivery strategy in biomedical applications	53
Fungal infections: Immune defense, immunotherapies and vaccines	52
Long-acting parenteral drug delivery systems for the treatment of chronic diseases	52
Photonic and magnetic materials for on-demand local drug delivery	52
Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor	52
Advances in modular control of CAR-T therapy with adapter-mediated CARs	52
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation	52
Precise subcellular targeting approaches for organelle-related disorders	51
Transdermal drug delivery via microneedles to mediate wound microenvironment	51
Biomedical engineering of two-dimensional MXenes	51
Advanced oral therapies for colorectal cancer via nanomedicine and microbiota modulation	51
Recent applications of three-dimensional bioprinting in drug discovery and development	50
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics	50
The RNA-binding protein HuR in human cancer: A friend or foe?	50
Stealth and pseudo-stealth nanocarriers	49
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling	49
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer	49
The effects of protein corona on in vivo fate of nanocarriers	49
Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria	49
Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids	49
Translating a radiolabeled imaging agent to the clinic	48
Characterization of dry powder inhaler performance through experimental methods	48
Editorial Board	48
Imaging and therapeutic targeting of the tumor immune microenvironment with biologics	48
Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery	48
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems	48
Bioengineering toolkits for potentiating organoid therapeutics	48
Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease	47
Novel antimicrobial agents for combating antibiotic-resistant bacteria	47
Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap	47
Advances in mRNA therapeutics for cancer immunotherapy: From modification to delivery	47
Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies	47
Gene editing therapeutics based on mRNA delivery	47
Advanced delivery systems for peptide antibiotics	47
Interaction of 2D nanomaterial with cellular barrier: Membrane attachment and intracellular trafficking	46
Materials and device design for advanced phototherapy systems	46
Effects of nanoparticle deformability on multiscale biotransport	46
3D printing of pharmaceutical dosage forms: Recent advances and applications	46
Polymeric in situ forming depots for long-acting drug delivery systems	46
Editorial board members	45
Nanomedicine for brain cancer	45
Emerging translational approaches for brain cancer therapeutics	45
Microbiome as an immune regulator in health, disease, and therapeutics	45
Clinical translation of nanomedicines: Challenges, opportunities, and keys	45
Interference of layered double hydroxide nanoparticles with pathways for biomedical applications	45
Current trends in delivery of non-viral nucleic acid-based therapeutics for improved efficacy	44
Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine	44
Functional antibody delivery: Advances in cellular manipulation	44
Editorial board members	44
Engineering nanosystems to overcome barriers to cancer diagnosis and treatment	44
The complex and intricate relationship between incremental science, innovation and recognition	44
DectiSomes: C-type lectin receptor-targeted liposomes as pan-antifungal drugs	44
Advances in local drug delivery technologies for improved rheumatoid arthritis therapy	44
Target- and prodrug-based design for fungal diseases and cancer-associated fungal infections	44
Encapsulation and immune protection for type 1 diabetes cell therapy	43
Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research	43
An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly	43
Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics	43
Advanced structural characterisation of pharmaceuticals using nano-thermal analysis (nano-TA)	43
Cytokine conjugates to elastin-like polypeptides	43
Mechanisms of immune response to inorganic nanoparticles and their degradation products	42
The role of RNA binding proteins in hepatocellular carcinoma	42
Immunoengineering strategies to enhance vascularization and tissue regeneration	42
Recent advances in 3D bioprinted neural models: A systematic review on the applications to drug discovery	41
Extracellular vesicles over adeno-associated viruses: Advantages and limitations as drug delivery platforms in precision medicine	41
Crossing borders in Alzheimer’s disease: A T cell’s perspective	41
Implantable systems for neurological chronotherapy	41
Themed issue: Extracellular vesicles in drug delivery and bioengineering	41
Advanced optical imaging for the rational design of nanomedicines	41
Editorial board members	41
Nitric oxide releasing graphene for next-generation therapeutics	40
Enhanced antimicrobial activity through the combination of antimicrobial photodynamic therapy and low-frequency ultrasonic irradiation	40
Nanoscale contrast agents: A promising tool for ultrasound imaging and therapy	40
Engineering in vivo behavior of DNA nanostructures toward organ-targeted drug delivery	40
Why nanoparticles prefer liver macrophage cell uptake in vivo	40
Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery	40
The spatiotemporal journey of nanomedicines in solid tumors on their therapeutic efficacy	39
Biophysical heterogeneity of myeloid-derived microenvironment to regulate resistance to cancer immunotherapy	39
Extracellular vesicles for improved tumor accumulation and penetration	39