Advanced Drug Delivery Reviews

Article	Citations
Editorial Board	514
Editorial board members	500
Editorial: Ocular drug delivery – Challenges, opportunities, and developments	311
Editorial board members	249
Special Issue (SI) on: Emerging pharmaceutical technologies (From advanced materials & formulations to new processes) for novel dosage development	240
Editorial board members	237
Trends in versatile 2D (sheet/paper-like) nanomaterials for biomedical applications	235
Preface: Phyto-derived nanomedicines for therapeutics, imaging and drug delivery	234
Agony of choice: How anesthetics affect the composition and function of extracellular vesicles	230
Editorial board members	216
Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient population	208
Liposomal formulations for treating lysosomal storage disorders	201
Therapeutic potential of pro-resolving mediators in diabetic kidney disease	195
Long-acting inhaled medicines: Present and future	189
The interaction between particles and vascular endothelium in blood flow	187
The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis	182
Targeting the tumor biophysical microenvironment to reduce resistance to immunotherapy	180
Plant-derived nanotherapeutic systems to counter the overgrowing threat of resistant microbes and biofilms	177
Pharmaceutical and biotech industry perspectives on optimizing patient experience and treatment adherence through subcutaneous drug delivery design	170
Cell and biomaterial delivery strategies to induce immune tolerance	166
Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies	163
Sensing technologies and experimental platforms for the characterization of advanced oral drug delivery systems	161
Therapeutic and delivery strategies of phytoconstituents for renal fibrosis	154
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders	151
An integrated perspective for the diagnosis and therapy of neurodevelopmental disorders – From an engineering point of view	148

Nanomedicine/materdicine-enabled sonocatalytic therapy	147
Gene editing strategies to treat lysosomal disorders: The example of mucopolysaccharidoses	144
Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles	139
Protein-engineered biomaterials for cartilage therapeutics and repair	137
Leveraging the neurosurgical operating room for therapeutic development in NeuroOncology	137
Advances in bacteria-based therapy for drug delivery	134
Emerging strategies in developing multifunctional nanomaterials for cancer nanotheranostics	134
Jet injectors: Perspectives for small volume delivery with lasers	132
Drug delivery strategies in maximizing anti-angiogenesis and anti-tumor immunity	131
Mastering the Gram-negative bacterial barrier – Chemical approaches to increase bacterial bioavailability of antibiotics	129
Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms	125
Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound	124
Strategies targeting tumor immune and stromal microenvironment and their clinical relevance	123
Using bugs as drugs: Administration of bacteria-related microbes to fight cancer	123
Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe	122
Cellular transformers for targeted therapy	120
Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties	118
The in vivo fate and targeting engineering of crossover vesicle-based gene delivery system	118
Drug delivery for metabolism targeted cancer immunotherapy	114
Advanced vaccine delivery	113
Monocytes as a convergent nanoparticle therapeutic target for cardiovascular diseases	113
Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond	111
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine	111
Revealing the clinical potential of high-resolution organoids	110
Spectroscopic techniques for monitoring stem cell and organoid proliferation in 3D environments for therapeutic development	110
Regulation of in vivo delivery of nanomedicines by herbal medicines	109
Cellular and molecular imaging of CAR-T cell-based immunotherapy	109
MicroRNAs and their delivery in diabetic fibrosis	108
Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies	107
Editorial Board	105
Prophylactic vaccine delivery systems against epidemic infectious diseases	105
Corrigendum to “Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic” [Adv. Drug Delivery Rev. 179 (2021) 114000]	103
Extracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds – A perspective	103
3D printing in musculoskeletal interface engineering: Current progress and future directions	102
Cell membrane-coated nanoparticles for targeting carcinogenic bacteria	101
Microbubble-assisted ultrasound for inner ear drug delivery	100
The era of nano-bionic: 2D materials for wearable and implantable body sensors	100
Progress of tumor-resident intracellular bacteria for cancer therapy	99
Smart gating porous particles as new carriers for drug delivery	98
Molecular imaging of innate immunity and immunotherapy	98
Nanovaccines with cell-derived components for cancer immunotherapy	98
Transflammation in tissue regeneration and response to injury: How cell-autonomous inflammatory signaling mediates cell plasticity	98
Challenging the fundamental conjectures in nanoparticle drug delivery for chemotherapy treatment of solid cancers	96
Extracellular vesicles as delivery systems at nano-/micro-scale	95
Current and prospective computational approaches and challenges for developing COVID-19 vaccines	95
Supramolecular engineering of hydrogels for drug delivery	95
Targeted to neuronal organelles for CNS drug development	93
Laser ablation: Heating up the anti-tumor response in the intracranial compartment	93
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers	93
Demystifying phytoconstituent-derived nanomedicines in their immunoregulatory and therapeutic roles in inflammatory diseases	93

Ocular therapies with biomacromolecules: From local injection to eyedrop and emerging noninvasive delivery strategies	92
Local delivery strategies to restore immune homeostasis in the context of inflammation	92
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics	91
Air-Liquid interface cultures to model drug delivery through the mucociliary epithelial barrier	91
Inhaled drug delivery for the targeted treatment of asthma	91
Current understandings and clinical translation of nanomedicines for breast cancer therapy	90
Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity	90
Sustained delivery approaches to improving adaptive immune responses	89
Microneedle-Mediated Vaccination: Innovation and Translation	89
Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopy	89
Recent advances of smart materials for ocular drug delivery	89
Advances in powder bed fusion 3D printing in drug delivery and healthcare	89
Towards artificial intelligence-enabled extracellular vesicle precision drug delivery	89
Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years	88
Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives	87
Emerging plasmonic nanoparticles and their assemblies for cancer radiotherapy	87
Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers	87
Development of nucleic acid medicines based on chemical technology	86
Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics	86
Delivery of synthetic mRNAs for tissue regeneration	86
The role of mucosal barriers in disease progression and transmission	86
Principles and applications of sono-optogenetics	86
Transcytosis-enabled active extravasation of tumor nanomedicine	85
Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors – An update	85
Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants	83
Bacterially mediated drug delivery and therapeutics: Strategies and advancements	83
Advancing pharmacy and healthcare with virtual digital technologies	83
Tools for computational design and high-throughput screening of therapeutic enzymes	82
Biologics and their delivery systems: Trends in myocardial infarction	81
Polysaccharide hydrogel platforms as suitable carriers of liposomes and extracellular vesicles for dermal applications	81
Application of colloidal photonic crystals in study of organoids	80
Theranostics applications of quantum dots in regenerative medicine, cancer medicine, and infectious diseases	80
The tendon microenvironment: Engineered in vitro models to study cellular crosstalk	80
Connected healthcare: Improving patient care using digital health technologies	79
Recent advances in endocrine organoids for therapeutic application	79
Nanoparticle-neutrophils interactions for autoimmune regulation	78
Harnessing artificial intelligence for the next generation of 3D printed medicines	78
Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment	78
2D materials-based nanomedicine: From discovery to applications	77
Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages	77
Upconversion nanomaterials and delivery systems for smart photonic medicines and healthcare devices	77
Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies	76
Long-acting PLGA microspheres: Advances in excipient and product analysis toward improved product understanding	76
Emerging delivery approaches for targeted pulmonary fibrosis treatment	75
Merging data curation and machine learning to improve nanomedicines	75
Artificial intelligence to bring nanomedicine to life	75
Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment	75
Biomaterial-based delivery of nucleic acids for tissue regeneration	74
Nanomedicine to fight infectious disease	74
Recent advances in long-acting drug delivery systems for anticancer drug	74
A new era in posterior segment ocular drug delivery: Translation of systemic, cell-targeted, dendrimer-based therapies	74
Penetration and translocation of functional inorganic nanomaterials into biological barriers	73
Models to study basic and applied aspects of lysosomal storage disorders	73
The role of coagulome in the tumor immune microenvironment	73
Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome	72
Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment	72
Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers	72
Self-assembling peptides as vectors for local drug delivery and tissue engineering applications	71
Frontiers in the treatment of glioblastoma: Past, present and emerging	71
Bioequivalence assessment of pharmaceutical aerosol products through IVIVC	70
Dosing extracellular vesicles	70
Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art	69
Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function	69
Biosafety of mesoporous silica nanoparticles; towards clinical translation	69
The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery	68
Mucosal drug delivery and 3D printing technologies: A focus on special patient populations	68
Tumor-on-chip modeling of organ-specific cancer and metastasis	67
Self-assembly of protein-polymer conjugates for drug delivery	67
Nano-delivery to the lung - by inhalation or other routes and why nano when micro is largely sufficient?	67
Deciphering albumin-directed drug delivery by imaging	67
Current treatment options and novel nanotechnology-driven enzyme replacement strategies for lysosomal storage disorders	66
Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads	66
Hydrogel drug delivery systems for minimally invasive local immunotherapy of cancer	65
Activatable dual-functional molecular agents for imaging-guided cancer therapy	65
Pharmaceutical applications of a nanospectroscopic technique: Surface-enhanced Raman spectroscopy	65
Recent applications of three-dimensional bioprinting in drug discovery and development	65
The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack	65
Gene- and RNAi-activated scaffolds for bone tissue engineering: Current progress and future directions	64
Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions	64
Drug delivery technologies for autoimmunity therapies	64

Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging	64
Drug delivery using gold nanoparticles	64
Editorial Board	64
Pathogenic fungi: Novel targets and theranostic strategies	63
Advances in modular control of CAR-T therapy with adapter-mediated CARs	63
Deepening the understanding of the in vivo and cellular fate of nanocarriers	62
Editorial Board	62
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease	61
Image-guided intratumoral immunotherapy: Developing a clinically practical technology	61
Rationally designed drug delivery systems for the local treatment of resected glioblastoma	61
Editorial Board	61
Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery	61
Leveraging advances in immunopathology and artificial intelligence to analyze in vitro tumor models in composition and space	61
Targeted drug delivery for maternal and perinatal health: Challenges and opportunities	61
Image-Guided Drug Delivery: Biomedical and Imaging Advances	60
Editorial board members	60
Editorial board members	60
Editorial board members	60
Editorial board members	60
Editorial Board	59
Editorial board members	59
Editorial/Preface	59
Editorial Board	58
Translational drug delivery: Time to be Frank for future success	58
Advances in solid formulation of pharmaceutical biologics	58
Emerging Voices in Drug Delivery – Harnessing and Modulating Complex Biological Systems (Issue 2)	58
Editorial board members	58
From the gut to the blood–brain barrier: Novel approaches for the treatment and targeted delivery of therapeutics in Alzheimer’s disease	57
Editorial board members	57
Editorial board members	57
Ocular immunosuppressive microenvironment and novel drug delivery for control of uveitis	56
Editorial board members	56
Towards single cell encapsulation for precision biology and medicine	56
In vitro and ex vivo models in inhalation biopharmaceutical research — advances, challenges and future perspectives	56
Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases	56
Emerging Voices in Drug Delivery – Breaking Barriers (Issue 1)	56
A systematic overview of strategies for photosensitizer and light delivery in antibacterial photodynamic therapy for lung infections	55
Myeloid cell-mediated drug delivery: From nanomedicine to cell therapy	55
Injectable systems for long-lasting insulin therapy	55
Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery	54
Cellular protein markers, therapeutics, and drug delivery strategies in the treatment of diabetes-associated liver fibrosis	54
Theme issue: In vitro mucus models	54
Current issues in optical monitoring of drug delivery via hair follicles	54
Dye Doped Metal-Organic Frameworks for Enhanced Phototherapy	53
The role of the HBCU pipeline in diversifying the STEM workforce: Training the next generation of drug delivery researchers	53
Synthetic RNA-based post-transcriptional expression control methods and genetic circuits	53
From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly	53
Human ocular mucins: The endowed guardians of sight	53
Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics	52
α-Amino acid N-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery	52
Synthetic biology-guided design and biosynthesis of protein polymers for delivery	52
Peptide-decorated nanocarriers penetrating the blood-brain barrier for imaging and therapy of brain diseases	52
Editorial to “Molecular engineering of biomaterials programmed to operate in living systems”	52
Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment	52
On the interface between biomaterials and two-dimensional materials for biomedical applications	52
Radiation-assisted strategies provide new perspectives to improve the nanoparticle delivery to tumor	51
Drugging the lymphatic system: An emerging opportunity for cancer immunotherapy	51
Patient-derived xenograft models of BRCA-associated pancreatic cancers	51
Phytonanomaterials as therapeutic agents and drug delivery carriers	51
Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening	51
Lipid nanoparticle formulations for targeting leukocytes with therapeutic RNA in liver fibrosis	51
Adaptive immune responses to SARS-CoV-2	51
In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols	50
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation	50
RNA therapies for CNS diseases	50
Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS	50
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics	50
Cyclodextrins applied to the treatment of lysosomal storage disorders	50
Elongated self-assembled nanocarriers: From molecular organization to therapeutic applications	50
Biomaterial-assisted macrophage cell therapy for regenerative medicine	50
Specific mechanical energy – An essential parameter in the processing of amorphous solid dispersions	49
Next generation concepts in dermal delivery, theranostics, and preclinical testing	49
Recent advances in lipid-based long-acting injectable depot formulations	49
The past, present, and future of breast cancer models for nanomedicine development	49
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer	49
Versatility on demand – The case for semi-solid micro-extrusion in pharmaceutics	48
Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic	48
Long-acting parenteral drug delivery systems for the treatment of chronic diseases	48
Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines	48
Lipid based nanocarriers for effective drug delivery and treatment of diabetes associated liver fibrosis	48
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling	48
In situ cellular hitchhiking of nanoparticles for drug delivery	48
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems	48
New antifungal strategies: Drug combination and co-delivery	47
Human skin equivalents: Impaired barrier function in relation to the lipid and protein properties of the stratum corneum	47
Extracellular vesicles are key players in mesenchymal stem cells’ dual potential to regenerate and modulate the immune system	47
Advancing cancer immunotherapy through siRNA-based gene silencing for immune checkpoint blockade	47
Ultrasound-activatable and skin-associated minimally invasive microdevices for smart drug delivery and diagnosis	47