Immunobiology

Article	Citations
Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab	113
Immunoinformatics-guided designing of epitope-based subunit vaccines against the SARS Coronavirus-2 (SARS-CoV-2)	65
Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies	60
Natural and trained innate immunity against Mycobacterium tuberculosis	53
The role of dectin-1 in health and disease	49
Exploiting the reverse vaccinology approach to design novel subunit vaccines against Ebola virus	39
TIGIT and PD-1 may serve as potential prognostic biomarkers for gastric cancer	38
Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling	34
SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation therapy as a novel treatment for COVID 19	33
Immunomodulatory significance of natural peptides in mammalians: Promising agents for medical application	29
Dioscin protects against diabetic nephropathy by inhibiting renal inflammation through TLR4/NF-κB pathway in mice	25
What do we know about the antibody responses to SARS-CoV-2?	23
Changes in macrophage inflammatory protein-1 (MIP-1) family members expression induced by traumatic brain injury in mice	23
Why blood group A individuals are at risk whereas blood group O individuals are protected from SARS-CoV-2 (COVID-19) infection: A hypothesis regarding how the virus invades the human body via ABO(H) b	23
Quercetin induces an immunoregulatory phenotype in maturing human dendritic cells	22
Advances in immunotherapy for the treatment of spinal cord injury	21
Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis	20
Immunoinformatics approach for a novel multi-epitope subunit vaccine design against various subtypes of Influenza A virus	19
Regulatory role of Apelin-13-mediated PI3K/AKT signaling pathway in the glucose and lipid metabolism of mouse with gestational diabetes mellitus	19
The role of macrophages type 2 and T-regs in immune checkpoint inhibitor related adverse events	18
MiR-183-5p overexpression in bone mesenchymal stem cell-derived exosomes protects against myocardial ischemia/reperfusion injury by targeting FOXO1	18
CCR2 and DPP9 expression in the peripheral blood of COVID-19 patients: Influences of the disease severity and gender	18
Inflammasome activation by NLRP1 and NLRC4 in patients with coronary stenosis	17
Roles of protein ubiquitination in inflammatory bowel disease	16
MBL deficiency-causing B allele (rs1800450) as a risk factor for severe COVID-19	16

Effects of TNF-α on autophagy of rheumatoid arthritis fibroblast-like synoviocytes and regulation of the NF-κB signaling pathway	15
Acquired decrease of the C3b/C4b receptor (CR1, CD35) and increased C4d deposits on erythrocytes from ICU COVID-19 patients	15
A method to differentiate chicken monocytes into macrophages with proinflammatory properties	15
Omicron variant infection and the associated immunological scenario	14
The mTOR-glycolytic pathway promotes T-cell immunobiology in oral lichen planus	14
Induction of CIITA by IFN-γ in macrophages involves STAT1 activation by JAK and JNK	14
GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function	14
Antigenic sites in SARS-CoV-2 spike RBD show molecular similarity with pathogenic antigenic determinants and harbors peptides for vaccine development	14
The host response to bacterial bone infection involves a local upregulation of several acute phase proteins	14
BCG immunomodulation: From the ‘hygiene hypothesis’ to COVID-19	14
Human bone marrow mesenchymal stem cells-derived exosomes protect against nerve injury via regulating immune microenvironment in neonatal hypoxic-ischemic brain damage model	14
LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer	13
A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites	13
Adiponectin and leptin levels in idiopathic pulmonary fibrosis: A new method for BAL and serum assessment	12
Complement and COVID-19: Three years on, what we know, what we don't know, and what we ought to know	12
Altered NK cell receptor repertoire and function of natural killer cells in patients with acute myocardial infarction: A three-month follow-up study	12
Immune induction by adjuvanted Leishmania donovani vaccines against the visceral leishmaniasis in BALB/c mice	12
Generation of novel trimeric fragments of human SP-A and SP-D after recombinant soluble expression in E. coli	12
Treatment with inhaled formulation of angiotensin-(1-7) reverses inflammation and pulmonary remodeling in a model of chronic asthma	12
Immunomodulatory effects and potential clinical applications of dimethyl sulfoxide	11
CircEXOC5 promotes ferroptosis by enhancing ACSL4 mRNA stability via binding to PTBP1 in sepsis-induced acute lung injury	11
Deciphering the balance of IL-6/IL-10 cytokines in severe to critical COVID-19 patients	11
Estrogen signaling differentially alters iron metabolism in monocytes in an Interleukin 6-dependent manner	10
β2 Integrin Gene (ITGB2) mutation spectra in Pakistani families with leukocyte adhesion deficiency type 1 (LAD1)	10
The role of CD68+ and CD163+ macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions	10
Pyruvate kinase M2 in lung APCs regulates Alternaria-induced airway inflammation	10
Mouse bone marrow-derived mesenchymal stem cells acquire immunogenicity concurrent with differentiation to insulin-producing cells	10
Association of interleukin-17 gene polymorphisms with the onset of Rheumatoid Arthritis	10
α9α10 nicotinic acetylcholine receptors regulate murine bone marrow granulocyte functions	10
Benznidazole: Hero or villain of cellular immune response in chronic Chagas disease patients?	10
Monophosphoryl lipid A directly regulates Th1 cytokine production in human CD4+ T-cells through Toll-like receptor 2 and 4	9
Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infection	9
TEAD4 transcriptional regulates SERPINB3/4 and affect crosstalk between keratinocytes and T cells in psoriasis	9
Bacterial lipoproteins in sepsis	9
Effects of total glucosides of paeony on acute renal injury following ischemia–reperfusion via the lncRNA HCG18/miR-16-5p/Bcl-2 axis	9
Upregulation of leukemia-induced non-coding activator RNA (LUNAR1) predicts poor outcome in pediatric T-acute lymphoblastic leukemia	9
PM2.5 induced lung injury through upregulating ROS-dependent NLRP3 Inflammasome-Mediated Pyroptosis	9
M-CSF- and L929-derived macrophages present distinct metabolic profiles with similar inflammatory outcomes	9
PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis	9
Preclinical characterization of a Fab-like CD3/CLDN18.2 XFab® bispecific antibody against solid tumors	8
Anti-complement factor I antibody associated atypical hemolytic uremic syndrome – A new insight for future perspective!	8
Long non-coding RNA RP11-490M8.1 inhibits lipopolysaccharide-induced pyroptosis of human umbilical vein endothelial cells via the TLR4/NF-κB pathway	8
Multinucleated giant cell phenotype in response to stimulation	8
Involvement of Xeroderma Pigmentosum Complementation Group G (XPG) in epigenetic regulation of T-Helper (TH) cell differentiation during breast cancer	8
Trophoblast cell influence on peripheral blood natural killer cell proliferation and phenotype in non-pregnant women and women in early pregnancy	8
Leukemia derived dendritic cell (DCleu) mediated immune response goes along with reduced (leukemia-specific) regulatory T-cells	8
Fungal β-glucans and mannan stimulate peripheral blood mononuclear cells to cytokine production in Syk-dependent manner	8
Low molecular weight cytotoxic components (DAMPs) form the post-COVID-19 syndrome	8
V-set domain containing T-cell activation inhibitor-1 (VTCN1): A potential target for the treatment of autoimmune diseases	8
Atorvastatin inhibits IL-17A, TNF, IL-6, and IL-10 in PBMC cultures from patients with severe rheumatoid arthritis	8

Linking murine resistance to secondary cystic echinococcosis with antibody responses targeting Echinococcus granulosus tegumental antigens	8
Nanoparticle-induced immune response: Health risk versus treatment opportunity?	8
An eosinophil-Sos1-RAS axis licenses corticosteroid resistance in patients with allergic rhinitis	7
The PE-PPE Family of Mycobacterium tuberculosis: Proteins in Disguise	7
Bavachin inhibits IL-4 expression by downregulating STAT6 phosphorylation and GATA-3 expression and ameliorates asthma inflammation in an animal model	7
Transient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 immune response in murine sporotrichosis caused by Sporothrix schenckii	7
A young girl with hypogammaglobulinemia and granulomatous hepatitis caused by a novel mutation in ZBTB24 gene: A case based analysis	7
Increased levels of the soluble oncostatin M receptor (sOSMR) and glycoprotein 130 (sgp130) in systemic sclerosis patients and associations with clinical parameters	7
NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells	7
Intestinal production of secreted protein acidic and rich in cysteine (SPARC) in patients with ulcerative colitis	7
Embryonic stem cells-derived exosomes enhance retrodifferentiation of retinal Müller cells by delivering BDNF protein to activate Wnt pathway	7
Exploring Kawasaki disease-specific hub genes revealing a striking similarity of expression profile to bacterial infections using weighted gene co-expression network analysis (WGCNA) and co-expression	7
Immunogenic efficacy of DNA and protein-based vaccine from a chimeric gene consisting OmpW, TcpA and CtxB, of Vibrio cholerae	7
Hypoxanthine Guanine Phosphoribosyltransferase expression is negatively correlated with immune activity through its regulation of purine synthesis	7
LncRNA OGFRP1 promotes angiogenesis and epithelial-mesenchymal transition in colorectal cancer cells through miR-423-5p/CTCF axis	6
Immune response modulation by allergen loaded into mesenchymal stem cell-derived exosomes as an effective carrier through sublingual immunotherapy	6
CCR4+ monocytic myeloid-derived suppressor cells are associated with the increased epithelial-mesenchymal transition in pancreatic adenocarcinoma patients	6
Cytotoxic activity of human dendritic cells induces RIPK1-dependent cell death	6
PPE2 protein of Mycobacterium tuberculosis affects myeloid hematopoiesis in mice	6
Adenosine receptor activation promotes macrophage class switching from LPS-induced acute inflammatory M1 to anti-inflammatory M2 phenotype	6
Epigenetics in non-classical monocytes support their pro-inflammatory gene expression	6
Effect of pathogenic crystals on the production of pro- and anti-inflammatory cytokines by different leukocyte populations	6
Polymorphisms in Toll-like receptors genes changes the host’s immune response and is associated with cervical cancer	6
The interplay of interleukin-17A and breast cancer tumor microenvironment as a novel immunotherapeutic approach to increase tumor immunogenicity	6
Identification of a novel TLR5 agonist derived from the P97 protein of Mycoplasma hyopneumoniae	6
Innate antiviral responses in porcine nasal mucosal explants inoculated with influenza A virus are comparable with responses in respiratory tissues after viral infection	6
Selective downregulation of natural killer activating receptors on NK cells and upregulation of PD-1 expression on T cells in children with severe and/or recurrent Herpes simplex virus infections	6
IL-27 regulates IL-4-induced chemokine production in human bronchial epithelial cells	6
Taurochenodeoxycholic acid reduces astrocytic neuroinflammation and alleviates experimental autoimmune encephalomyelitis in mice	6
Quercetin acts as a novel anti-cancer drug to suppress cancer aggressiveness and cisplatin-resistance in nasopharyngeal carcinoma (NPC) through regulating the yes-associated protein/Hippo signaling pa	6
RNASeq analysis reveals upregulation of complement C3 in the offspring gut following prenatal stress in mice	6
The MHC-II antigen presentation machinery and B7 checkpoint ligands display distinctive patterns correlated with acute myeloid leukaemias blast cells HLA-DR expression	6
Role of FSCN1 in the tumor microenvironment of lung squamous cell carcinoma	5
Diagnosis of radiosensitive severe combined immunodeficiency disease (RS-SCID) by Comet Assay, management of bone marrow transplantation	5
Streptococcal arginine deiminase regulates endothelial inflammation, mTOR pathway and autophagy	5
Protective effect of two new nanovaccines against Pseudomonas aeruginosa based on LPS and OPS: A comparison study	5
IL-37 alleviates TNF-α-induced pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes by inhibiting the NF-κB/GSDMD signaling pathway	5
Lactobacillus delbrueckii UFV-H2b20 increases IFN-γ production and CD39+CD73+ Treg cell numbers in lungs, and protects mice against experimental allergic asthma	5
TLR2 and TLR4 mRNA expression levels in liver transplant patients with acute rejection	5
Estrogen receptors in human bladder cells regulate innate cytokine responses to differentially modulate uropathogenic E. coli colonization	5
STING mediates SU5416/hypoxia-induced pulmonary arterial hypertension in rats by regulating macrophage NLRP3 inflammasome activation	5
Identification of a peptide targeting CD56	5
Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation	5
Novel inflammatory targets for immunotherapies in pediatric patients with trichotillomania	5
STC1 ameliorates cognitive impairment and neuroinflammation of Alzheimer’s disease mice via inhibition of ERK1/2 pathway	5
Arginase is involved in cervical lesions progression and severity	5
The Nurr7 agonist Cytosporone B differentially regulates inflammatory responses in human polarized macrophages	5
Association of epidermal differentiation complex (EDC) genetic variants with House Dust Mite sensitization in Atopic Dermatitis Patients	5
Reduced frequency and functional potency of CD49d− T regulatory cells in patients with newly diagnosed type 2 diabetes mellitus	5
Immunomodulatory role of Th17 pathway in experimental visceral leishmaniasis	5
CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL/J mouse model of relapsing-remitting multiple sclerosis	5
Macrophage Migration Inhibitory Factor contributes to drive phenotypic and functional macrophages activation in response to Toxoplasma gondii infection	5
ST6GAL1 polymorphisms influence susceptibility and progression of IgA nephropathy in a Chinese Han population	5
Expression profile of MUC1 protein in Pigeon allergens positive asthmatic	5
Development of dominant epitope-based vaccines encoding Gp63, Kmp-11 and Amastin against visceral leishmaniasis	5
IL-33 synergistically promotes the proliferation of lung cancer cells in vitro by inducing antibacterial peptide LL-37 and proinflammatory cytokines in macrophages	5
Different roles of intracellular and extracellular reactive oxygen species of neutrophils in type 2 diabetic mice with invasive aspergillosis	4
The role of IL-17A/IL-17RA and lung injuries in children with lethal non-pandemic acute viral pneumonia	4
Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages	4
Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer	4
CD14 regulates the metabolomic profiles of distinct macrophage subsets under steady and activated states	4
Proportion of B cell subsets and Nrf2 mediated redox regulation in systemic lupus erythematosus patients	4
PD-L1 and PD-L2 immune checkpoint protein induction by type III interferon in non-small cell lung cancer cells	4
Post-translational suppression of the high affinity IgE receptor expression on mast cells by an intestinal bacterium	4
Monitoring of autoantibodies against CYP4Z1 in patients with colon, ovarian, or prostate cancer	4
Patients with moderate to severe COVID-19 have an impaired cytokine response with an exhausted and senescent immune phenotype	4
Regulatory tumor-infiltrating lymphocytes prevail in endometrial tumors with low vascular survival ability	4
IL-27 regulates autophagy in rheumatoid arthritis fibroblast-like synoviocytes via STAT3 signaling	4
Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?	4
ERAP1 binds peptide C-termini of different sequences and/or lengths by a common recognition mechanism	4
The TGFB1 -509C/T polymorphism and elevated TGF-β1 levels are associated with chronic hepatitis C and cirrhosis	4
Study on the additive protective effect of PGLYRP3 and Bifidobacterium adolescentis Reuter 1963 on severity of DSS-induced colitis in Pglyrp3 knockout (Pglyrp3 −/−) and wild-type (WT) mice	4
Pan genome based reverse vaccinology approach to explore Enterococcus faecium (VRE) strains for identification of novel multi-epitopes vaccine candidate	4
Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis	4
Physiological estrogen levels are dispensable for the sex difference in immune responses during allergen-induced airway inflammation	4
Changes in extracellular cytokines in predicting disease severity and final clinical outcome of patients with blunt chest trauma	4
Diagnostic biomarkers of dilated cardiomyopathy	4
An optimized method to visualize the goblet cell-associated antigen passages and identify goblet cells in the intestine, conjunctiva, and airway	4
Down-regulation of MLLT1 super elongation complex subunit impairs the anti-tumor activity of natural killer cells in esophageal cancer	3
The establishment of humanized IL-4/IL-4RA mouse model by gene editing and efficacy evaluation	3

Leucine rich repeats and calponin homology domain containing 1 inhibits NK-92 cell cytotoxicity through attenuating Src signaling	3
Modulatory effect of rapamycin and tacrolimus on monocyte-derived dendritic cells phenotype and function	3
Down-regulation of miR-18b-5p protects against splenic hemorrhagic shock by directly targeting HIF-1α/iNOS pathway	3
In-silico immunoinformatic analysis of SARS-CoV-2 virus for the development of putative vaccine construct	3
CD4 and IL-2 mediated NK cell responses after COVID-19 infection and mRNA vaccination in adults	3
Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway	3
Highlighting the versatility of the citrullination process	3
Abatement of cyclophosphamide-induced splenic immunosuppressive indoleamine 2, 3-dioxygenase and altered hematological indices in Wister rats by dietary quercetin	3
Anti-neutrophil antibodies (anti-MPO-ANCAs) are associated with poor prognosis in breast cancer patients	3
Omenn syndrome caused by a novel homozygous mutation in recombination activating gene 1	3
MerTK negatively regulates Staphylococcus aureus induced inflammatory response via SOCS1/SOCS3 and Mal	3
Evaluation of the anti-inflammatory effects of PI3Kδ/γ inhibitors for treating acute lung injury	3
Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia	3
Non-coding RNA network associated with obesity and rheumatoid arthritis	3
Fluid shear stress enhances dendritic cell activation	3
PAC1 deficiency attenuates progression of atherosclerosis in ApoE deficient mice under cholesterol-enriched diet	3
Immunological screening of Lassa Virus among Health workers and Contacts of patients of Lassa fever in Ondo State	3
In vitro immunobiological assays of methotrexate-stearic acid conjugate in human PBMCs	3
MYD88, IRAK3 and Rheumatoid Arthritis pathogenesis: Analysis of differential gene expression in CD14 + monocytes and the inflammatory cytokine levels	3
The role of dendritic cells in neuroblastoma: Implications for immunotherapy	3
Interleukin 17, the double-edged sword in atherosclerosis	3
Minimal structure of IRAK-1 to induce degradation of TRAF6	3
Human B cells infected by Trypanosoma cruzi undergo F-actin disruption and cell death via caspase-7 activation and cleavage of phospholipase Cγ1	3
Flow cytometry profiling of cellular immune response in COVID-19 infected, recovered and vaccinated individuals	3
Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation	3
Innate and adaptive immune responses against Influenza A Virus: Immune evasion and vaccination strategies	3
Successful perioperative management of three patients with hereditary angioedema without C1 esterase inhibitor therapy: A developing country perspective	3
An association of iNKT+/CD3+/CD161+ lymphocytes in ovarian cancer tissue with CA125 serum concentration	3
Deregulated phenotype of autoreactive Th17 and Treg clone cells in pemphigus vulgaris after in-vitro treatment with desmoglein antigen (Dsg-3)	3
In vitro characterization of granulocyte-colony stimulating factor (G-CSF) production by dendritic cells and macrophages during Streptococcus suis infection	3
Properdin produced by dendritic cells contributes to the activation of T cells	3
Association between severe diabetic retinopathy and lectin pathway proteins – an 18-year follow-up study with newly diagnosed type 1 diabetes patients	3
A combined ratio change of inflammatory biomarkers at 72 h could predict the severity and prognosis of sepsis from pulmonary infections	3
Formyl peptide receptor 2 (FPR2) antagonism is a potential target for the prevention of Brucella abortus 544 infection	3
Effect of Lacticaseibacillus rhamnosus and Lactiplantibacillus plantarum isolated from food and human origin on reduction of IgE-dependent hypersensitivity in Balb/c mice	3
Induced antigen-binding polyreactivity in human serum IgA	3
Development of a novel trivalent invasive non-typhoidal Salmonella outer membrane vesicles based vaccine against salmonellosis and fowl typhoid in chickens	3
Effects of TRIM59 on RAW264.7 macrophage gene expression and function	3
A multilocus genetic study evidences the association of autoimmune-related genes with Psoriatic Arthritis in Italian patients	3
IL-6, IL-10, sFas, granulysin and indicators of intestinal permeability as early biomarkers for a fatal outcome in COVID-19	3
Regulatory relationship between macrophage autophagy and PVL-positive methicillin-resistant Staphylococcus aureus	3
Assessment of changes in immune status linked to COVID-19 convalescent and its clinical severity in patients and uninfected exposed relatives	3
Exploring the relationship between pyroptosis, infiltrating immune cells and Kawasaki disease with resistance to intravenous immunoglobulin (IVIG) via bioinformatic analysis	3