Applied Microbiology and Biotechnology

Article	Citations
Microplastics provide new microbial niches in aquatic environments	219
Detection technologies and recent developments in the diagnosis of COVID-19 infection	199
The microbial coinfection in COVID-19	195
Crosstalk between ER stress, NLRP3 inflammasome, and inflammation	144
Industrial biotechnology of Pseudomonas putida: advances and prospects	131
Role of probiotics to combat viral infections with emphasis on COVID-19	118
Recent advances and new strategies on leishmaniasis treatment	111
Application of artificial intelligence models and optimization algorithms in plant cell and tissue culture	108
Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics	101
Microbial astaxanthin biosynthesis: recent achievements, challenges, and commercialization outlook	94
The potential of Akkermansia muciniphila in inflammatory bowel disease	91
Indole-3-acetic acid biosynthesis and its regulation in plant-associated bacteria	90
Several ways one goal—methanogenesis from unconventional substrates	89
Biotechnology of Rhodococcus for the production of valuable compounds	87
Production of bioactive plant secondary metabolites through in vitro technologies—status and outlook	76
Auxins of microbial origin and their use in agriculture	75
A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress–induced depressive-like behavior in mice by regulating gut microbiota and metabolites	70
Bacillus as a source of phytohormones for use in agriculture	66
Fungal bioremediation of soil co-contaminated with petroleum hydrocarbons and toxic metals	65
Health benefits of xylitol	63
The role of microorganisms on biotransformation of brewers’ spent grain	61
Lizhong decoction ameliorates ulcerative colitis in mice via modulating gut microbiota and its metabolites	60
Green synthesis of multipurpose carbon quantum dots from red cabbage and estimation of their antioxidant potential and bio-labeling activity	58
Biogenesis of silver nanoparticles to treat cancer, diabetes, and microbial infections: a mechanistic overview	57
Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets	57

(Bio)Technological aspects of microalgae pigments for cosmetics	56
Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story	54
Motility of Vibrio spp.: regulation and controlling strategies	53
Advances on the in vivo and in vitro glycosylations of flavonoids	53
Progress in bioleaching: part B, applications of microbial processes by the minerals industries	52
Engineering intracellular malonyl-CoA availability in microbial hosts and its impact on polyketide and fatty acid synthesis	52
Unraveling microbial fermentation features in kimchi: from classical to meta-omics approaches	51
Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae	51
Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections	50
Echinocandins: structural diversity, biosynthesis, and development of antimycotics	50
Current status on the biodegradability of acrylic polymers: microorganisms, enzymes and metabolic pathways involved	49
Catalytically-active inclusion bodies for biotechnology—general concepts, optimization, and application	48
Mannitol: physiological functionalities, determination methods, biotechnological production, and applications	48
Administration of Bifidobacterium bifidum CGMCC 15068 modulates gut microbiota and metabolome in azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis-associated colon cancer (CAC) in mice	48
Alterations of Akkermansia muciniphila in the inflammatory bowel disease patients with washed microbiota transplantation	47
Campylobacter sp.: Pathogenicity factors and prevention methods—new molecular targets for innovative antivirulence drugs?	47
Lipid metabolism of the oleaginous yeast Lipomyces starkeyi	47
Biosynthesis and regulation of anthocyanin pathway genes	47
Riboflavin-overproducing lactobacilli for the enrichment of fermented soymilk: insights into improved nutritional and functional attributes	46
Progress in bioleaching: fundamentals and mechanisms of microbial metal sulfide oxidation – part A	46
Anaerobic biodegradation of phenol in wastewater treatment: achievements and limits	45
Distillers’ dried grains with solubles (DDGS) and its potential as fermentation feedstock	45
Biofilm formation and inhibition mediated by bacterial quorum sensing	45
Engineering of the unfolded protein response pathway in Pichia pastoris: enhancing production of secreted recombinant proteins	45
Catechin isolated from cashew nut shell exhibits antibacterial activity against clinical isolates of MRSA through ROS-mediated oxidative stress	42
The “beauty in the beast”—the multiple uses of Priestia megaterium in biotechnology	42
Antimicrobial activities of plasma-functionalized liquids against foodborne pathogens on grass carp (Ctenopharyngodon Idella)	42
Synthesis, biomedical applications, and toxicity of CuO nanoparticles	41
Lactobacillus plantarum FRT10 alleviated high-fat diet–induced obesity in mice through regulating the PPARα signal pathway and gut microbiota	40
The research of aptamer biosensor technologies for detection of microorganism	39
The periodic table of fermented foods: limitations and opportunities	39
Microbial single-cell omics: the crux of the matter	39
The interaction of Akkermansia muciniphila with host-derived substances, bacteria and diets	39
Responses of soil bacterial and fungal communities to the long-term monoculture of grapevine	39
Edible mushroom industry in China: current state and perspectives	39
Valorisation of pectin-rich agro-industrial residues by yeasts: potential and challenges	39
An overview and future prospects on aptamers for food safety	39
In vitro antifungal activity of Cinnamomum zeylanicum bark and leaf essential oils against Candida albicans and Candida auris	39
The multifunctional lifestyles of Metarhizium: evolution and applications	39
Modeling and optimizing callus growth and development in Cannabis sativa using random forest and support vector machine in combination with a genetic algorithm	39
Computation-aided engineering of starch-debranching pullulanase from Bacillus thermoleovorans for enhanced thermostability	38
Novel mycosynthesis of Co3O4, CuO, Fe3O4, NiO, and ZnO nanoparticles by the endophytic Aspergillus terreus and evaluation of their antioxidant and antimicrobial activities	38
Streptomycetes as platform for biotechnological production processes of drugs	38
Gut microbiome analysis as a predictive marker for the gastric cancer patients	38
Sequential fed-batch fermentation of 1,3-propanediol from glycerol by Clostridium butyricum DL07	37
L-asparaginase production review: bioprocess design and biochemical characteristics	37
Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain–based vaccine candidate, RBD219-N1C1	37
Hairy root culture technology: applications, constraints and prospect	37
Characterization and function of membrane vesicles in Gram-positive bacteria	36
Living with sulfonamides: a diverse range of mechanisms observed in bacteria	36

Production of the anticancer drug taxol by the endophytic fungus Epicoccum nigrum TXB502: enhanced production by gamma irradiation mutagenesis and immobilization technique	36
Microorganisms populating the water-related indoor biome	36
Anti-fungal properties and mechanisms of melittin	35
Comparative methods for fecal sample storage to preserve gut microbial structure and function in an in vitro model of the human colon	35
Development of chitosan-coated agar-gelatin particles for probiotic delivery and targeted release in the gastrointestinal tract	35
Smart drug delivery against Helicobacter pylori: pectin-coated, mucoadhesive liposomes with antiadhesive activity and antibiotic cargo	35
Phenotypic and molecular insights into heat tolerance of formulated cells as active ingredients of fungal insecticides	35
Compound Lactobacillus sp. administration ameliorates stress and body growth through gut microbiota optimization on weaning piglets	35
Biodegradation of fipronil: current state of mechanisms of biodegradation and future perspectives	35
Adaptive laboratory evolution of Yarrowia lipolytica improves ferulic acid tolerance	35
Soy bioactive peptides and the gut microbiota modulation	34
Flavin-dependent N-hydroxylating enzymes: distribution and application	34
Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer	34
Assessment of overall microbial community shift during Cheddar cheese production from raw milk to aging	34
Surfactin and fengycin B extracted from Bacillus pumilus W-7 provide protection against potato late blight via distinct and synergistic mechanisms	34
Fungal secondary metabolites in food and pharmaceuticals in the era of multi-omics	34
Possible mechanisms for the equilibrium of ACC and role of ACC deaminase-producing bacteria	34
Probiotic and nutritional effects of Debaryomyces hansenii on animals	34
Release mechanisms and molecular interactions of Pseudomonas aeruginosa extracellular DNA	34
One-pot platform for rapid detecting virus utilizing recombinase polymerase amplification and CRISPR/Cas12a	33
Multidisciplinary characterization of melanin pigments from the black fungus Cryomyces antarcticus	33
A comparative study of microbial community and functions of type 2 diabetes mellitus patients with obesity and healthy people	33
Progress of cationic gene delivery reagents for non-viral vector	33
D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity	33
Quorum sensing signal autoinducer-2 promotes root colonization of Bacillus velezensis SQR9 by affecting biofilm formation and motility	32
Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE−/− mice through modulation of proinflammatory cytokines and oxidative stress	32
Bacterial catabolism of indole-3-acetic acid	32
Thermostability engineering of industrial enzymes through structure modification	32
Biotechnological production of lycopene by microorganisms	32
An overview on marine cellulolytic enzymes and their potential applications	32
Antifungal mechanism of 1-nonanol against Aspergillus flavus growth revealed by metabolomic analyses	32
The influence of phosphorus source and the nature of nitrogen substrate on the biomass production and lipid accumulation in oleaginous Mucoromycota fungi	31
Current view on novel vaccine technologies to combat human infectious diseases	31
Gut microbiota profiles and characterization of cultivable fungal isolates in IBS patients	31
Thanatomicrobiome and epinecrotic community signatures for estimation of post-mortem time interval in human cadaver	31
Synthesis and production of steviol glycosides: recent research trends and perspectives	31
Rice-shrimp culture: a better intestinal microbiota, immune enzymatic activities, and muscle relish of crayfish (Procambarus clarkii) in Sichuan Province	31
Pecularities and applications of aryl-alcohol oxidases from fungi	31
Biological activity of oxadiazole and thiadiazole derivatives	31
Lactobacillus salivarius LI01 encapsulated in alginate-pectin microgels ameliorates d-galactosamine-induced acute liver injury in rats	31
The impact of metal pipe materials, corrosion products, and corrosion inhibitors on antibiotic resistance in drinking water distribution systems	31
Perspectives for the microbial production of ethyl acetate	31
Optimization of nitric oxide donors for investigating biofilm dispersal response in Pseudomonas aeruginosa clinical isolates	30
Towards sustainable agriculture: rhizosphere microbiome engineering	30
The effect of bile acids on the growth and global gene expression profiles in Akkermansia muciniphila	30
Bacillus subtilis High Cell Density Fermentation Using a Sporulation-Deficient Strain for the Production of Surfactin	30
Perspective on the biotechnological production of bacterial siderophores and their use	30
Sugar alcohols derived from lactose: lactitol, galactitol, and sorbitol	30
Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes	30
Ligilactobacillus salivarius functionalities, applications, and manufacturing challenges	30
Milk fermented by Lactobacillus casei CRL431 administered as an immune adjuvant in models of breast cancer and metastasis under chemotherapy	29
Impact of novel microbial secondary metabolites on the pharma industry	29
Sporulation in solventogenic and acetogenic clostridia	29
Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses	29
Natural bacterial isolates as an inexhaustible source of new bacteriocins	29
Towards control of cellulose biosynthesis by Komagataeibacter using systems-level and strain engineering strategies: current progress and perspectives	29
Machine learning: its challenges and opportunities in plant system biology	29
Psychrophilic enzymes: structural adaptation, pharmaceutical and industrial applications	29
Enterobacteriaceae in food safety with an emphasis on raw milk and meat	28
Current advance in biological production of short-chain organic acid	28
New insights in pectinase production development and industrial applications	28
Reductive soil disinfestation incorporated with organic residue combination significantly improves soil microbial activity and functional diversity than sole residue incorporation	28
Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota	28
The strategies to reduce cost and improve productivity in DHA production by Aurantiochytrium sp.: from biochemical to genetic respects	28
Identification and engineering a C4-dicarboxylate transporter for improvement of malic acid production in Aspergillus niger	28
Itaconic acid derivatives: structure, function, biosynthesis, and perspectives	28
Antifungal activity of different Xenorhabdus and Photorhabdus species against various fungal phytopathogens and identification of the antifungal compounds from X. szentirmaii	28
Drug repurposing strategies in the development of potential antifungal agents	28
Glycerol monolaurate improves performance, intestinal development, and muscle amino acids in yellow-feathered broilers via manipulating gut microbiota	28
Elevation rather than season determines the assembly and co-occurrence patterns of soil bacterial communities in forest ecosystems of Mount Gongga	28
Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb	27
Bacillibactin class of siderophore antibiotics from a marine symbiotic Bacillus as promising antibacterial agents	27
Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus	27
Harmful effects of metal(loid) oxide nanoparticles	27
Development of a p72 trimer–based colloidal gold strip for detection of antibodies against African swine fever virus	27
Introducing a hybrid artificial intelligence method for high-throughput modeling and optimizing plant tissue culture processes: the establishment of a new embryogenesis medium for chrysanthemum, as a	27
Exploiting endophytic microbes as micro-factories for plant secondary metabolite production	27
Antifungal activity of silver nanoparticles synthesized by iturin against Candida albicans in vitro and in vivo	27
OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potential	26
Development of thermostable sucrose phosphorylase by semi-rational design for efficient biosynthesis of alpha-D-glucosylglycerol	26

Biotransformation ability of endophytic fungi: from species evolution to industrial applications	26
High-level expression of aryl-alcohol oxidase 2 from Pleurotus eryngii in Pichia pastoris for production of fragrances and bioactive precursors	26
Construction of lactic acid-tolerant Saccharomyces cerevisiae by using CRISPR-Cas-mediated genome evolution for efficient d-lactic acid production	26
Genomic and transcriptomic perspectives on mycoremediation of polycyclic aromatic hydrocarbons	26
Thermostable lipases and their dynamics of improved enzymatic properties	26
In-depth understanding of molecular mechanisms of aldehyde toxicity to engineer robust Saccharomyces cerevisiae	26
Origins and features of pectate lyases and their applications in industry	26
An overview and future prospects of recombinant protein production in Bacillus subtilis	26
Potential role of IFN-α in COVID-19 patients and its underlying treatment options	26
Key elements and regulation strategies of NRPSs for biosynthesis of lipopeptides by Bacillus	25
Changes in microbial community in the presence of oil and chemical dispersant and their effects on the corrosion of API 5L steel coupons in a marine-simulated microcosm	25
Recent advancements for microorganisms and their natural compounds useful in agriculture	25
Metabolic engineering of Saccharomyces cerevisiae for enhanced production of caffeic acid	25
High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cells	25
Pediococcus pentosaceus ZJUAF-4 relieves oxidative stress and restores the gut microbiota in diquat-induced intestinal injury	25
Biotechnological strategies for the sustainable production of diosgenin from Dioscorea spp.	25
Pseudomonas putida and its close relatives: mixing and mastering the perfect tune for plants	24
Difficidin class of polyketide antibiotics from marine macroalga-associated Bacillus as promising antibacterial agents	24
Bacteria associated with cockroaches: health risk or biotechnological opportunity?	24
ARTP mutation and adaptive laboratory evolution improve probiotic performance of Bacillus coagulans	24
Production of bacterial cellulose from whey—current state and prospects	24
Recent advances in microbial production of L-malic acid	24
Development and application of a colloidal-gold dual immunochromatography strip for detecting African swine fever virus antibodies	24
Mucoromycota fungi as powerful cell factories for modern biorefinery	24
Old yellow enzymes: structures and structure-guided engineering for stereocomplementary bioreduction	23
Regulatory effects of transition metals supplementation/deficiency on the gut microbiota	23
Eco-friendly polyurethane acrylate (PUA)/natural filler-based composite as an antifouling product for marine coating	23
A novel β-galactosidase from Klebsiella oxytoca ZJUH1705 for efficient production of galacto-oligosaccharides from lactose	23
The antifungal mechanisms of plant volatile compound 1-octanol against Aspergillus flavus growth	23
Recent advances and new strategies in Leishmaniasis diagnosis	23
Whole-plant corn silage improves rumen fermentation and growth performance of beef cattle by altering rumen microbiota	23
Research progress and the biotechnological applications of multienzyme complex	23
Comparative roles of three adhesin genes (adh1–3) in insect-pathogenic lifecycle of Beauveria bassiana	23
Effect of quorum-sensing molecule 2-phenylethanol and ARO genes on Saccharomyces cerevisiae biofilm	23
Serendipita indica alleviates drought stress responses in walnut (Juglans regia L.) seedlings by stimulating osmotic adjustment and antioxidant defense system	23
Staphylococcins: an update on antimicrobial peptides produced by staphylococci and their diverse potential applications	23
Modeling the dynamic kinetics of microbial disinfection with dissipating chemical agents—a theoretical investigation	23
Spatial and seasonal variations of sediment bacterial communities in a river-bay system in South China	23
Unraveling the anti-biofilm potential of green algal sulfated polysaccharides against Salmonella enterica and Vibrio harveyi	23
The newly synthesized thiazole derivatives as potential antifungal compounds against Candida albicans	23
Thiamine: a key nutrient for yeasts during wine alcoholic fermentation	23
Assessment of ethanol tolerance of Kluyveromyces marxianus CCT 7735 selected by adaptive laboratory evolution	23
A tunable l-arabinose-inducible expression plasmid for the acetic acid bacterium Gluconobacter oxydans	23
Antibacterial and safety tests of a flexible cold atmospheric plasma device for the stimulation of wound healing	23
Evolutionary and reverse engineering to increase Saccharomyces cerevisiae tolerance to acetic acid, acidic pH, and high temperature	23
Current and potential biotechnological applications of odorant-binding proteins	23
Purification, characterization, and mode of action of Paracin 54, a novel bacteriocin against Staphylococci	23
An overview of Trichoderma reesei co-cultures for the production of lignocellulolytic enzymes	22
Synbiotic VSL#3 and yacon-based product modulate the intestinal microbiota and prevent the development of pre-neoplastic lesions in a colorectal carcinogenesis model	22
Inducing red pigment and inhibiting citrinin production by adding lanthanum(III) ion in Monascus purpureus fermentation	22
Current insights into the microbial degradation for butachlor: strains, metabolic pathways, and molecular mechanisms	22
The community compositions of three nitrogen removal wastewater treatment plants of different configurations in Victoria, Australia, over a 12-month operational period	22
Early-life lactoferrin intervention modulates the colonic microbiota, colonic microbial metabolites and intestinal function in suckling piglets	22
Toxin-antitoxin systems and their medical applications: current status and future perspective	22
Combined isoflavones biotransformation increases the bioactive and antioxidant capacity of soymilk	22
Chemoenzymatic synthesis of daptomycin analogs active against daptomycin-resistant strains	22
Seed coating as a delivery system for the endophyte Trichoderma koningiopsis Th003 in rice (Oryza sativa)	22
Strategies for enhancing terpenoids accumulation in microalgae	22
New knowledge about the biosynthesis of lovastatin and its production by fermentation of Aspergillus terreus	22
Metagenomic insights into the effect of sulfate on enhanced biological phosphorus removal	22
Stochastic processes shape the bacterial community assembly in shrimp cultural pond sediments	22
Genetic tools for the redirection of the central carbon flow towards the production of lactate in the human gut bacterium Phocaeicola (Bacteroides) vulgatus	22
Recent progress and trends in the analysis and identification of rhamnolipids	22
FvatfA regulates growth, stress tolerance as well as mycotoxin and pigment productions in Fusarium verticillioides	22
Towards green extraction methods from microalgae learning from the classics	22
Synergistic antimicrobial activity of N-methyl substituted pyrrolidinium–based ionic liquids and melittin against Gram-positive and Gram-negative bacteria	21
Phytotoxic compounds from endophytic fungi	21
Comparison of the fermentation and bacterial community in the colon of Hu sheep fed a low-grain, non-pelleted, or pelleted high-grain diet	21
Sequencing of SARS-CoV-2 genome using different nanopore chemistries	21
Exploring the molecular content of CHO exosomes during bioprocessing	21
Antimicrobial peptides used as growth promoters in livestock production	21
Shifts of microbiota during cheese production: impact on production and quality	21
Interactive effects of light quality and culturing temperature on algal cell size, biomass doubling time, protein content, and carbohydrate content	21
Fungal mutualisms and pathosystems: life and death in the ambrosia beetle mycangia	21
α-l-Fucosidases and their applications for the production of fucosylated human milk oligosaccharides	21
Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, plantaricin GZ1-27 and its inhibition of biofilm formation	21
Natural products from Photorhabdus and Xenorhabdus: mechanisms and impacts	21
Molecular strategies to increase keratinase production in heterologous expression systems for industrial applications	21
Genome-scale metabolic network models: from first-generation to next-generation	21
Phage therapeutics: from promises to practices and prospectives	21
Development of a constitutive and an auto-inducible high-yield expression system for recombinant protein production in the microalga Nannochloropsis oceanica	21
Biodegradation of lignin monomers and bioconversion of ferulic acid to vanillic acid by Paraburkholderia aromaticivorans AR20-38 isolated from Alpine forest soil	21
6-Methylcoumarin attenuates quorum sensing and biofilm formation in Pseudomonas aeruginosa PAO1 and its applications on solid surface coatings with polyurethane	21
Temporal dynamics of gut microbiota in caged laying hens: a field observation from hatching to end of lay	21
Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods	21
Recent advances of Cas12a applications in bacteria	20
Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine	20
Recombinant Treponema pallidum protein Tp0768 promotes proinflammatory cytokine secretion of macrophages through ER stress and ROS/NF-κB pathway	20
The functions of glutathione peroxidase in ROS homeostasis and fruiting body development in Hypsizygus marmoreus	20
Biodegradation of diisononyl phthalate by a consortium of saline soil bacteria: optimisation and kinetic characterisation	20
Panorama of intron dynamics and gene rearrangements in the phylum Basidiomycota as revealed by the complete mitochondrial genome of Turbinellus floccosus	20
Relevance of Candidatus Nitrotoga for nitrite oxidation in technical nitrogen removal systems	20
Heat preadaptation improved the ability of Zygosaccharomyces rouxii to salt stress: a combined physiological and transcriptomic analysis	20
Biotechnological utilization: the role of Zea mays rhizospheric bacteria in ecosystem sustainability	20
Ethyl carbamate in Chinese liquor (Baijiu): presence, analysis, formation, and control	20